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61 results on '"Rubi, M."'

1. P021 Higher TNFα and IL-6 mucosal levels in ulcerative colitis patients with more severe endoscopic activity

Author

Calviño Suárez, C, primary, Martinez-Rodriguez, A L, additional, Moreira-Alvarez, D, additional, Ardao-Palacios, I, additional, Duran-Rubi, M, additional, Ferreiro-Iglesias, R, additional, Baston-Rey, I, additional, Porto-Silva, S, additional, Nieto-Garcia, L, additional, Varela-Liste, M J, additional, Brea-Floriani, J M, additional, Dominguez-Munoz, J E, additional, Loza-Garcia, M, additional, and Barreiro-de Acosta, M, additional

Published
2024
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2. Rational design of a trimeric APRIL-based CAR-binding domain enables efficient targeting of multiple myeloma

Author

Schmidts, Andrea, Ormhøj, Maria, Choi, Bryan D., Taylor, Allison O., Bouffard, Amanda A., Scarfò, Irene, Larson, Rebecca C., Frigault, Matthew J., Gallagher, Kathleen, Castano, Ana P., Riley, Lauren S., Cabral, Maria L., Boroughs, Angela C., Velasco Cárdenas, Rubí M.-H., Schamel, Wolfgang, Zhou, Jing, Mackay, Sean, Tai, Yu-Tzu, Anderson, Kenneth C., and Maus, Marcela V.

Published
2019
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3. Coordinating AgMIP data and models across global and regional scales for 1.5°C and 2.0°C assessments

Author

Rosenzweig, Cynthia, Ruane, Alex C., Antle, John, Elliott, Joshua, Ashfaq, Muhammad, Chatta, Ashfaq Ahmad, Ewert, Frank, Folberth, Christian, Hathie, Ibrahima, Havlik, Petr, Hoogenboom, Gerrit, Lotze-Campen, Hermann, MacCarthy, Dilys S., Mason-D’Croz, Daniel, Contreras, Erik Mencos, Müller, Christoph, Perez-Dominguez, Ignacio, Phillips, Meridel, Porter, Cheryl, Raymundo, Rubi M., Sands, Ronald D., Schleussner, Carl-Friedrich, Valdivia, Roberto O., Valin, Hugo, and Wiebe, Keith

Published
2018

5. Influence of Hydrodynamic Interactions on the Adsorption Process of Large Particles

Author

Pagonabarraga, I. and Rubi, M.

Subjects
Condensed Matter
Abstract

We have studied the adsorption process of non-Brownian particles on a line incorporating hydrodynamic interactionsa and we have numerically analyzed their effect on typical relevant quantities. We compare our model to the ballistic deposition model (BM) and address the limitations of BM in experimental situations. The results obtained can explain some differences observed between recent experiments and BM predictions., Comment: 10 pages, LaTeX. 4 Figures upon request

Published
1994
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6. Long-Range Correlations in Diffusive Systems Away from Equilibrium

Author

Pagonabarraga, I. and Rubi, M.

Subjects
Condensed Matter
Abstract

We study the dynamics of density fluctuations in purely diffusive systems away from equilibrium. Under some conditions the static density correlation function becomes long-ranged. We then analyze this behavior in the framework of nonequilibrium fluctuating hydrodynamics., Comment: 15 pages, LaTex

Published
1993
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7. Liderazgo transformacional directivo y motivación laboral en docentes de una Institución Educativa Privada de Lima

Author

Rubi M Chuman Vasquez

Abstract

El presente artículo se direccionó a “determinar el nivel de relación entre el liderazgo transformacional directivo y la motivación laboral en docentes de una Institución Educativa Privada de Lima”. Siendo de enfoque cuantitativo, diseño no experimental de tipo descriptivo -correlacional. La población abarcó 90 docentes siendo considerada en la muestra a la totalidad de esta denominado muestra censal. Empleándose como instrumentos dos cuestionarios: uno orientado al “Liderazgo transformacional directivo” y otro a la “motivación laboral” obteniéndose como resultados una correlación moderada entre las variables implicadas por lo que, en síntesis, existe una correlación significativa entre el “liderazgo transformacional directivo” y la “motivación laboral” de los docentes en la Institución Educativa Privada de Lima repercutiendo este estilo de liderazgo de manera positiva en la motivación de su personal docente evidenciándose un buen entorno laboral lo cual genera la continuidad de la investigación en la temática abordada.

Published
2023

11. Localized Amyloidosis: About 36 Cases

Author

Paccalin, M., primary, Rubi, M., additional, Hachulla, E., additional, Carreiro, M., additional, Tricot, L., additional, Wechsler, B., additional, Cabane, J., additional, Cazalet, C., additional, and Roblot, P., additional

Published
2004
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12. Localized Amyloidosis

Author

Cabane, J, primary, Hachulla, E, additional, Wechsler, B, additional, Rubi, M, additional, Paccalin, M, additional, Cazalet, C, additional, Carreiro, M, additional, Roblot, P, additional, and Tricot, L, additional

Published
2004
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13. Fig. S3 from Coordinating AgMIP data and models across global and regional scales for 1.5°C and 2.0°C assessments

Author

Rosenzweig, Cynthia, Ruane, Alex C., Antle, John, Elliott, Joshua, Ashfaq, Muhammad, Chatta, Ashfaq Ahmad, Ewert, Frank, Folberth, Christian, Ibrahima Hathie, Havlik, Petr, Hoogenboom, Gerrit, Lotze-Campen, Hermann, MacCarthy, Dilys S., Mason-D'Croz, Daniel, Contreras, Erik Mencos, Müller, Christoph, Perez-Dominguez, Ignacio, Meridel Phillips, Porter, Cheryl, Raymundo, Rubi M., Sands, Ronald D., Carl-Friedrich Schleussner, Valdivia, Roberto O., Valin, Hugo, and Wiebe, Keith

Abstract

Difference between 2.0 °C and 1.5 °C on rainfed maize with (left) and without (right) CO2 effects for three global gridded crop models (pDSSAT, GEPIC, LPJmL).

Published
2018
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14. The Relationship Between Body Mass Index and Sexual Function in Endometrial Cancer

Author

Deborah Watkins Bruner, William Small, Jessica S. Wells, Alexandra L. Hanlon, Jonathan B. Strauss, Rubi M. Garcia, and Lilie L. Lin

Subjects
Adult, medicine.medical_specialty, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Medicine, Humans, 030212 general & internal medicine, Reproductive health, Aged, business.industry, Obstetrics, Endometrial cancer, Small sample, Secondary data, Middle Aged, medicine.disease, Endometrial Neoplasms, Postmenopause, Sexual Dysfunction, Physiological, Sexual dysfunction, 030220 oncology & carcinogenesis, Quality of Life, Female, medicine.symptom, business, Sexual function, Body mass index, Follow-Up Studies
Abstract

Objectives To explore the association between pretreatment body mass index (BMI) and post-treatment sexual function in women treated for endometrial cancer. . Sample & setting 28 postmenopausal women treated with vaginal brachytherapy (VBT) took part in this multisite exploratory secondary analysis at the University of Pennsylvania and Northwestern University. . Methods & variables Secondary data analysis was used to determine if pretreatment BMI is associated with post-VBT sexual function in postmenopausal women treated for endometrial cancer at baseline and at six months post-treatment. Because of small sample size, participants were dichotomized according to enrollment BMI. Results Both groups had poor sexual function at baseline. Although improved function was observed with time, neither group reached a score indicating healthy sexual function. . Implications for nursing Understanding factors that influence sexual health in patients with gynecologic cancer can improve post-treatment quality of life. .

Published
2017

15. Biophysical and economic implications for agriculture of +1.5° and +2.0°C global warming using AgMIP Coordinated Global and Regional Assessments

Author

Ruane, Alex C; Antle, John; Elliott, Joshua; Folberth, Christian; Hoogenboom, Gerrit; Mason-D'Croz, Daniel; Müller, Christoph; Porter, Cheryl H.; Phillips, Meridel M.; Raymundo, Rubi M.; Sands, Ronald D.; Valdivia, Roberto; White, Jeffrey W.; Wiebe, Keith D.; Rosenzweig, Cynthia, http://orcid.org/0000-0003-0673-2301 Mason-D'Croz, Daniel; http://orcid.org/0000-0001-6035-620X Wiebe, Keith, Ruane, Alex C; Antle, John; Elliott, Joshua; Folberth, Christian; Hoogenboom, Gerrit; Mason-D'Croz, Daniel; Müller, Christoph; Porter, Cheryl H.; Phillips, Meridel M.; Raymundo, Rubi M.; Sands, Ronald D.; Valdivia, Roberto; White, Jeffrey W.; Wiebe, Keith D.; Rosenzweig, Cynthia, and http://orcid.org/0000-0003-0673-2301 Mason-D'Croz, Daniel; http://orcid.org/0000-0001-6035-620X Wiebe, Keith

Abstract

PR, IFPRI3; ISI; CRP2; CRP7; 1 Fostering Climate-Resilient and Sustainable Food Supply; Global Futures and Strategic Foresight, EPTD; PIM, CGIAR Research Program on Policies, Institutions, and Markets (PIM); CGIAR Research Program on Climate Change, Agriculture and Food Security (CCAFS), This study presents results of the Agricultural Model Intercomparison and Improvement Project (AgMIP) Coordinated Global and Regional Assessments (CGRA) of +1.5° and +2.0°C global warming above pre-industrial conditions. This first CGRA application provides multi-discipline, multi-scale, and multi-model perspectives to elucidate major challenges for the agricultural sector caused by direct biophysical impacts of climate changes as well as ramifications of associated mitigation strategies. Agriculture in both target climate stabilizations is characterized by differential impacts across regions and farming systems, with tropical maize Zea mays experiencing the largest losses, while soy Glycine max mostly benefits. The result is upward pressure on prices and area expansion for maize and wheat Triticum aestivum, while soy prices and area decline (results for rice Oryza sativa are mixed). An example global mitigation strategy encouraging bioenergy expansion is more disruptive to land use and crop prices than the climate change impacts alone, even in the +2.0°C scenario which has a larger climate signal and lower mitigation requirement than the +1.5°C scenario. Coordinated assessments reveal that direct biophysical and economic impacts can be substantially larger for regional farming systems than global production changes. Regional farmers can buffer negative effects or take advantage of new opportunities via mitigation incentives and farm management technologies. Primary uncertainties in the CGRA framework include the extent of CO2 benefits for diverse agricultural systems in crop models, as simulations without CO2 benefits show widespread production losses that raise prices and expand agricultural area.

Published
2018

19. Predicting outcome after traumatic brain injury: Practical prognostic models based on large cohort of international patients

Author

Perel, P. A., Olldashi, F., Muzha, I., Filipi, N., Lede, R., Copertari, P., Traverso, C., Copertari, A., Vergara, E. A., Montenegro, C., De Huidobro, R. R., Saladino, P., Surt, K., Cialzeta, J., Lazzeri, S., Pinero, G., Ciccioli, F., Videtta, W., Barboza, M. F., Svampa, S., Sciuto, V., Domeniconi, G., Bustamante, M., Waschbusch, M., Gullo, M. P., Drago, D. A., Linares, J. C. A., Camputaro, L., Troccoli, G., Galimberti, H., Tallott, M., Eybner, C., Buchinger, W., Fitzal, S., Mazairac, G., Oleffe, V., Grollinger, T., Delvaux, P., Carlier, L., Braet, V., Jacques, J. -M., De Knoop, D., Nasi, L., Choi, H. K., Schmitt, M., Gentil, A., Nacul, F., Barrios, P. B., Xinkang, C., Hua, L. S., Tian, H. H., Xiaodong, C., Gualteros, W., Otero, A. A., Arango, M., Ciro, J., Jaramillo, H., Gonzalez, I., Gomez, C., Arias, A., Fonseca, M., Mora, C., Cabrera, E. G. L., Betancurth, J. L., Munoz, P., Quinonez, J. A., Castillo, M. E. G., Lopez, O., Yepes, R. P., Cuellar, D. L., Paez, G., Chaves, H. D., Ordonez, P. E., Plata, Riccardo, Pineda, M., Pulido, L. E., Jaramillo, J. S. V., Rebolledo, C., Palma, O., Soler, C., Pastrana, I., Falero, R., Perera, M. D., Garcia, A. A., Oliva, R., Delgado, H. L., Carnero, A. M., Lopez, B. L., Gallardo, A. L., Morales, A. O., Lezcano, H., Ferrer, M. I., Bess, I. Z., Canino, G. R., Ruiz, E. M. P., Cruz, O. G., Svoboda, P., Kantorova, I., Ochmann, J., Scheer, P., Kozumplik, L., Marsova, J., Edelmann, K., Chytra, I., Bosman, R., Andrejsova, H., Pachl, J., Burger, J., Kramar, F., Ulloa, M. I., Gonzalez, L., Daccach, A., Ortega, A., Cevallos, S., Cueva, B. Z., Ochoa, M., Tapia, J. V., Hurtado, J., Wong, M. C. S., Santos, R., Khamis, H., Abaza, A. H., Fekry, A., El Kordy, S., Shawky, T., El-Sayed, H., Khalil, N., Negm, N., Fisal, S., Alamin, M., Shokry, H., Elhusseny, A. Y., Radwan, A., Rashid, M., Gogichaisvili, T., Ingorokva, G., Gongadze, N., Otarashvili, A., Kleist, W., Kalkum, M., Ulrich, P., Andrews, N., Nakos, G., Karavelis, A., Archontakis, G., Myrianthefs, P., Yadav, Y., Yadav, S., Khatri, R., Baghel, A., Husain, M., Jha, D., Chhang, W. H., Dhandhania, M., Fonning, C., Iyengar, S. N., Gupta, S., Ravi, R. R., Bopiah, K. S., Herur, A., Venkataramana, N. K., Satish, A., Bhavadasan, K., Morris, R., Ramesh, S., Dewan, Y., Singh, Y., Bhagchandani, R., Bhagchandani, S., Sethurayar, V. U., Ipe, S., Sreekumar, G., Panigrahi, M., Reddy, A., Khosla, V., Pillay, H., Thomas, N., Sridhar, K., Jose, B., Kurian, N., Praharaj, S., Pillai, S., Ramana, Kiyawat, D., Maheshwari, K., Panikar, D., Chawla, J., Shenoy, S., Raja, A., Rupayana, Y., Reddy, S., Mohan, N., Kelkar, S., Johri, M., Golden, N., Maliawan, S., Fauzi, A., Farouk, U., Fakharian, E., Aramesh, A., Eghtedari, M., Ahmadzadeh, F., Gholami, A., Plunkett, P., Redican, C., Mcmahon, G., Annetta, Maria Giuseppina, Mouchaty, H., Bruzzone, E., Harding, B., Qureshi, M., Idris, Z., Jafri Abdullah, N. C., Ghazali, G., Ghani, A. R. I., Cheah, F., Cabrera, A., Gonzalez, J. L. M., Loria-Castellanos, J., Jackson, S., Hutchinson, R., Komolafe, E., Adeolu, A., Komolafe, M., Adeyemi-Doro, O., Bankole, F., Shehu, B., Danlami, V., Odebode, O., Oluwadiya, K., Sanni, A., Giebel, H., Kumar, S., Jooma, R., Mezquita, J. E., Ovelar, C. O., Portillo, M. G., Rodriguez, D., Balica, L., Oprita, B., Sklerniacof, M., Steflea, L., Bandut, L., Danil, A., Iliescu, R., Ciurea, J., El-Dawlatly, A., Alwatidy, S., Al-Yafi, W., El-Dawlatly, M., Krunic-Protic, R., Janosevic, V., Tan, J., Seah, C., Trenkler, S., Humenansky, M., Stajancova, T., Schwendt, I., Laincz, A., Julius, Z., Maros, S., Firment, J., Cifranicova, M., Saniova, B., Kalig, K., Medekova, S., Wiszt, R., Macuga, I., Hartzenberg, B., Du Plessis, G., Houlie, Z., Nathoo, N., Khumalo, S., Tracey, R., Munoz-Sanchez, A., Francisco Murillo-Cabezas, N. C., Flores-Cordero, J., Rincon- Ferrari, D., Rubi, M., Caler, L., Del Campo, M. M., Laguna, L. B., Nava, J. M., Minguillon, M. A., Lopez, A. M., Ramos-Gomez, L., De La Torre-Prados, V., Pellejero, R., Laloe, V., Mandrella, B., Suganthan, Perera, S., Mahendran, K., Stocker, R., Ludwig, S., Zimmermann, H., Denzler, U., Yutthakasemsunt, S., Kittiwattanagul, W., Piyavechvirat, P., Tapsai, P., Namuang-Jan, A., Chantapimpa, U., Watanachai, C., Subsompon, P., Pussanakawatin, W., Khunjan, P., Tangchitvittaya, S., Nilapong, S., Klangsang, T., Taechakosol, W., Srinat, A., Jerbi, Z., Borsali- Falfoul, N., Rezgui, M., Cakar, N., Ssenyonjo, H., Kobusingye, O., Lomas, G., Yates, D., Lecky, F., Bleetman, A., Baldwin, A., Jenkinson, E., Pantrini, S., Stewart, J., Contractor, N., Roberts, T., Butler, J., Pinto, A., Lee, D., Brayley, N., Robbshaw, K., Dix, C., Graham, S., Pye, S., Green, M., Kellins, A., Moulton, C., Fogg, B., Cottingham, R., Funnell, S., Shanker, U., Summers, C., Malek, L., Ashcroft, C., Powell, J., Moore, S., Buckley, S., Grocutt, M., Chambers, S., Morrice, A., Marshall, H., Harris, J., Matthews, W., Tippet, J., Mardell, S., Macmillan, F., Shaw, A., Luthra, P., Dixon, G., Ahmed, M., Young, M., Mason, S., Loveday, I., Clark, C., Taylor, S., Wilson, P., Ali, K., Greenwood, S., White, M., Perez, R., Eljamel, S., Wasserberg, J., Shale, H., Read, C., Mccarron, J., Pennell, A., Ray, G., Thurston, J., Brown, E., Jaffey, L., Graves, M., Bailey, R., Loveridge, N., Evans, G., Hughes, S., Ahmed, M. K., Richardson, J., Gallagher, C., Odedun, T., Lees, K., Foley, D., Payne, N., Pennycook, A., Griffiths, C., Moore, D., Byrne, D., Dasan, S., Banerjee, Abhishek, Mcguinness, S., Chikhani, C., Zoltie, N., Barlow, I., Stell, I., Hulse, W., Crossley, J., Watkins, L., Dorani, B., Van Viet, T., Plata R., Annetta M. G. (ORCID:0000-0001-7574-1311), Banerjee A., Perel, P. A., Olldashi, F., Muzha, I., Filipi, N., Lede, R., Copertari, P., Traverso, C., Copertari, A., Vergara, E. A., Montenegro, C., De Huidobro, R. R., Saladino, P., Surt, K., Cialzeta, J., Lazzeri, S., Pinero, G., Ciccioli, F., Videtta, W., Barboza, M. F., Svampa, S., Sciuto, V., Domeniconi, G., Bustamante, M., Waschbusch, M., Gullo, M. P., Drago, D. A., Linares, J. C. A., Camputaro, L., Troccoli, G., Galimberti, H., Tallott, M., Eybner, C., Buchinger, W., Fitzal, S., Mazairac, G., Oleffe, V., Grollinger, T., Delvaux, P., Carlier, L., Braet, V., Jacques, J. -M., De Knoop, D., Nasi, L., Choi, H. K., Schmitt, M., Gentil, A., Nacul, F., Barrios, P. B., Xinkang, C., Hua, L. S., Tian, H. H., Xiaodong, C., Gualteros, W., Otero, A. A., Arango, M., Ciro, J., Jaramillo, H., Gonzalez, I., Gomez, C., Arias, A., Fonseca, M., Mora, C., Cabrera, E. G. L., Betancurth, J. L., Munoz, P., Quinonez, J. A., Castillo, M. E. G., Lopez, O., Yepes, R. P., Cuellar, D. L., Paez, G., Chaves, H. D., Ordonez, P. E., Plata, Riccardo, Pineda, M., Pulido, L. E., Jaramillo, J. S. V., Rebolledo, C., Palma, O., Soler, C., Pastrana, I., Falero, R., Perera, M. D., Garcia, A. A., Oliva, R., Delgado, H. L., Carnero, A. M., Lopez, B. L., Gallardo, A. L., Morales, A. O., Lezcano, H., Ferrer, M. I., Bess, I. Z., Canino, G. R., Ruiz, E. M. P., Cruz, O. G., Svoboda, P., Kantorova, I., Ochmann, J., Scheer, P., Kozumplik, L., Marsova, J., Edelmann, K., Chytra, I., Bosman, R., Andrejsova, H., Pachl, J., Burger, J., Kramar, F., Ulloa, M. I., Gonzalez, L., Daccach, A., Ortega, A., Cevallos, S., Cueva, B. Z., Ochoa, M., Tapia, J. V., Hurtado, J., Wong, M. C. S., Santos, R., Khamis, H., Abaza, A. H., Fekry, A., El Kordy, S., Shawky, T., El-Sayed, H., Khalil, N., Negm, N., Fisal, S., Alamin, M., Shokry, H., Elhusseny, A. Y., Radwan, A., Rashid, M., Gogichaisvili, T., Ingorokva, G., Gongadze, N., Otarashvili, A., Kleist, W., Kalkum, M., Ulrich, P., Andrews, N., Nakos, G., Karavelis, A., Archontakis, G., Myrianthefs, P., Yadav, Y., Yadav, S., Khatri, R., Baghel, A., Husain, M., Jha, D., Chhang, W. H., Dhandhania, M., Fonning, C., Iyengar, S. N., Gupta, S., Ravi, R. R., Bopiah, K. S., Herur, A., Venkataramana, N. K., Satish, A., Bhavadasan, K., Morris, R., Ramesh, S., Dewan, Y., Singh, Y., Bhagchandani, R., Bhagchandani, S., Sethurayar, V. U., Ipe, S., Sreekumar, G., Panigrahi, M., Reddy, A., Khosla, V., Pillay, H., Thomas, N., Sridhar, K., Jose, B., Kurian, N., Praharaj, S., Pillai, S., Ramana, Kiyawat, D., Maheshwari, K., Panikar, D., Chawla, J., Shenoy, S., Raja, A., Rupayana, Y., Reddy, S., Mohan, N., Kelkar, S., Johri, M., Golden, N., Maliawan, S., Fauzi, A., Farouk, U., Fakharian, E., Aramesh, A., Eghtedari, M., Ahmadzadeh, F., Gholami, A., Plunkett, P., Redican, C., Mcmahon, G., Annetta, Maria Giuseppina, Mouchaty, H., Bruzzone, E., Harding, B., Qureshi, M., Idris, Z., Jafri Abdullah, N. C., Ghazali, G., Ghani, A. R. I., Cheah, F., Cabrera, A., Gonzalez, J. L. M., Loria-Castellanos, J., Jackson, S., Hutchinson, R., Komolafe, E., Adeolu, A., Komolafe, M., Adeyemi-Doro, O., Bankole, F., Shehu, B., Danlami, V., Odebode, O., Oluwadiya, K., Sanni, A., Giebel, H., Kumar, S., Jooma, R., Mezquita, J. E., Ovelar, C. O., Portillo, M. G., Rodriguez, D., Balica, L., Oprita, B., Sklerniacof, M., Steflea, L., Bandut, L., Danil, A., Iliescu, R., Ciurea, J., El-Dawlatly, A., Alwatidy, S., Al-Yafi, W., El-Dawlatly, M., Krunic-Protic, R., Janosevic, V., Tan, J., Seah, C., Trenkler, S., Humenansky, M., Stajancova, T., Schwendt, I., Laincz, A., Julius, Z., Maros, S., Firment, J., Cifranicova, M., Saniova, B., Kalig, K., Medekova, S., Wiszt, R., Macuga, I., Hartzenberg, B., Du Plessis, G., Houlie, Z., Nathoo, N., Khumalo, S., Tracey, R., Munoz-Sanchez, A., Francisco Murillo-Cabezas, N. C., Flores-Cordero, J., Rincon- Ferrari, D., Rubi, M., Caler, L., Del Campo, M. M., Laguna, L. B., Nava, J. M., Minguillon, M. A., Lopez, A. M., Ramos-Gomez, L., De La Torre-Prados, V., Pellejero, R., Laloe, V., Mandrella, B., Suganthan, Perera, S., Mahendran, K., Stocker, R., Ludwig, S., Zimmermann, H., Denzler, U., Yutthakasemsunt, S., Kittiwattanagul, W., Piyavechvirat, P., Tapsai, P., Namuang-Jan, A., Chantapimpa, U., Watanachai, C., Subsompon, P., Pussanakawatin, W., Khunjan, P., Tangchitvittaya, S., Nilapong, S., Klangsang, T., Taechakosol, W., Srinat, A., Jerbi, Z., Borsali- Falfoul, N., Rezgui, M., Cakar, N., Ssenyonjo, H., Kobusingye, O., Lomas, G., Yates, D., Lecky, F., Bleetman, A., Baldwin, A., Jenkinson, E., Pantrini, S., Stewart, J., Contractor, N., Roberts, T., Butler, J., Pinto, A., Lee, D., Brayley, N., Robbshaw, K., Dix, C., Graham, S., Pye, S., Green, M., Kellins, A., Moulton, C., Fogg, B., Cottingham, R., Funnell, S., Shanker, U., Summers, C., Malek, L., Ashcroft, C., Powell, J., Moore, S., Buckley, S., Grocutt, M., Chambers, S., Morrice, A., Marshall, H., Harris, J., Matthews, W., Tippet, J., Mardell, S., Macmillan, F., Shaw, A., Luthra, P., Dixon, G., Ahmed, M., Young, M., Mason, S., Loveday, I., Clark, C., Taylor, S., Wilson, P., Ali, K., Greenwood, S., White, M., Perez, R., Eljamel, S., Wasserberg, J., Shale, H., Read, C., Mccarron, J., Pennell, A., Ray, G., Thurston, J., Brown, E., Jaffey, L., Graves, M., Bailey, R., Loveridge, N., Evans, G., Hughes, S., Ahmed, M. K., Richardson, J., Gallagher, C., Odedun, T., Lees, K., Foley, D., Payne, N., Pennycook, A., Griffiths, C., Moore, D., Byrne, D., Dasan, S., Banerjee, Abhishek, Mcguinness, S., Chikhani, C., Zoltie, N., Barlow, I., Stell, I., Hulse, W., Crossley, J., Watkins, L., Dorani, B., Van Viet, T., Plata R., Annetta M. G. (ORCID:0000-0001-7574-1311), and Banerjee A.

Abstract

Objective: To develop and validate practical prognostic models for death at 14 days and for death or severe disability six months after traumatic brain injury. Design: Multivariable logistic regression to select variables that were independently associated with two patient outcomes. Two models designed: "basic" model (demographic and clinical variables only) and "CT" model (basic model plus results of computed tomography). The models were subsequently developed for high and low-middle income countries separately. Setting: Medical Research Council (MRC) CRASH Trial. Subjects: 10 008 patients with traumatic brain injury. Models externally validated in a cohort of 8509. Results: The basic model included four predictors: age, Glasgow coma scale, pupil reactivity, and the presence of major extracranial injury. The CT model also included the presence of petechial haemorrhages, obliteration of the third ventricle or basal cisterns, subarachnoid bleeding, midline shift, and non-evacuated haematoma. In the derivation sample the models showed excellent discrimination (C statistic above 0.80). The models showed good calibration graphically. The Hosmer-Lemeshow test also indicated good calibration, except for the CT model in low-middle income countries. External validation for unfavourable outcome at six months in high income countries showed that basic and CT models had good discrimination (C statistic 0.77 for both models) but poorer calibration. Conclusion: Simple prognostic models can be used to obtain valid predictions of relevant outcomes in patients with traumatic brain injury.

Published
2008

21. Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial): Randomised placebo-controlled trial

Author

Olldashi, F., Muzha, I., Filipi, N., Lede, R., Copertari, P., Traverso, C., Copertari, A., Vergara, E. A., Montenegro, C., De Huidobro, R. R., Surt, K., Cialzeta, J., Lazzeri, S., Pinero, G., Ciccioli, F., Videtta, W., Barboza, M. F., Svampa, S., Sciuto, V., Domeniconi, G., Bustamante, M., Waschbusch, M., Gullo, M. P., Drago, D. A., Linares, J. C. A., Camputaro, L., Troccoli, G., Galimberti, H., Tallott, M., Eybner, C., Buchinger, W., Fitzal, S., Mazairac, G., Oleffe, V., Grollinger, T., Delvaux, P., Carlier, L., Braet, V., Jacques, J. -M., De Knoop, D., Nasi, L., Choi, H. K., Schmitt, M., Gentil, A., Nacul, F., Barrios, P. B., Xinkang, C., Hua, L. S., Tian, H. H., Xiaodong, C., Gualteros, W., Otero, A. A., Arango, M., Ciro, J., Jaramillo, H., Garcia, G., Gonzalez, I., Gomez, C., Arias, A., Fonseca, M., Mora, C., Cabrera, E. G. L., Betancurth, J. L., Munoz, P., Quinonez, J. A., Castillo, M. E. G., Lopez, O., Yepes, R. P., Cuellar, D. L., Paez, G., Chaves, H. D., Ordonez, P. E., Plata, Riccardo, Pineda, M., Pulido, L. E., Jaramillo, J. S. V., Rebolledo, C., Palma, O., Soler, C., Pastrana, I., Falero, R., Perera, M. D., Garcia, A. A., Oliva, R., Delgado, H. L., Carnero, A. M., Lopez, B. L., Gallardo, A. L., Morales, A. O., Lezcano, H., Ferrer, M. I., Bess, I. Z., Canino, G. R., Ruiz, E. M. P., Cruz, O. G., Svoboda, P., Kantorova, I., Ochmann, J., Scheer, P., Kozumplik, L., Marsova, J., Edelmann, K., Chytra, I., Bosman, R., Andrejsova, H., Pachl, J., Burger, J., Kramar, F., Ulloa, M. I., Gonzalez, L., Daccach, A., Ortega, A., Cevallos, S., Cueva, B. Z., Ochoa, M., Tapia, J. V., Hurtado, J., Wong, M. C. S., Santos, R., Khamis, H., Abaza, A. H., Fekry, A., El Kordy, S., Shawky, T., El-Sayed, H., Khalil, N., Negm, N., Fisal, S., Shokry, H., Alamin, M., Elhusseny, A. Y., Radwan, A., Rashid, M., Gogichaisvili, T., Ingorokva, G., Gongadze, N., Otarashvili, A., Kleist, W., Kalkum, M., Ulrich, P., Andrews, N., Nakos, G., Karavelis, A., Archontakis, G., Myrianthefs, P., Yadav, Y., Yadav, S., Khatri, R., Baghel, A., Husain, M., Jha, D., Hoong Chhang, W., Dhandhania, M., Fonning, C., Iyengar, S. N., Gupta, S., Ravi, R. R., Bopiah, K. S., Herur, A., Venkataramana, N. K., Satish, A., Bhavadasan, K., Morris, R., Ramesh, S., Dewan, Y., Singh, Y., Bhagchandani, R., Bhagchandani, S., Sethurayar, V., Ipe, S., Sreekumar, G., Panigrahi, M., Reddy, A., Khosla, V., Pillay, H., Thomas, N., Sridhar, K., Jose, B., Kurian, N., Praharaj, S., Pillai, S., Ramana, Kiyawat, D., Maheshwari, K., Panikar, D., Chawla, J., Shenoy, S., Raja, A., Rupayana, Y., Reddy, S., Mohan, N., Kelkar, S., Johri, M., Golden, N., Maliawan, S., Fauzi, A., Farouk, U., Fakharian, E., Aramesh, A., Eghtedari, M., Ahmadzadeh, F., Gholami, A., Plunkett, P., Redican, C., Mcmahon, G., Annetta, Maria Giuseppina, Mouchaty, H., Bruzzone, E., Harding, B., Qureshi, M., Idris, Z., Abdullah, J., Ghazali, G., Ghani, A., Cheah, F., Gonzalez, J., Loria-Castellanos, J., Jackson, S., Hutchinson, R., Komolafe, E., Adeolu, A., Komolafe, M., Adeyemi-Doro, O., Bankole, F., Shehu, B., Danlami, V., Odebode, O., Oluwadiya, K., Sanni, A., Giebel, H., Kumar, S., Jooma, R., Mezquita, J., Ortiz Ovelar, C., Gonzales-Portillo, M., Rodriguez, D., Balica, L., Oprita, B., Sklerniacof, M., Steflea, L., Bandut, L., Danil, A., Iliescu, R., Ciurea, J., El-Dawlatly, A., Alwatidy, S., Al-Yafi, W., El-Dawlatly, M., Krunic-Protic, R., Janosevic, V., Tan, J., Seah, C., Trenkler, S., Humenansky, M., Stajancova, T., Schwendt, I., Laincz, A., Julius, Z., Maros, S., Firment, J., Cifranicova, M., Saniova, B., Kalig, K., Medekova, S., Wiszt, R., Macsuga, I., Hartzenberg, B., Du Plessis, G., Houlie, Z., Nathoo, N., Khumalo, S., Tracey, R., Munoz-Sanchez, A., Murillo-Cabezas, F., Flores-Cordero, J., Rincon-Ferrari, D., Rubi, M., Caler, L., Del Campo, M., Laguna, L., Manuel Nava, J., Minguillon, M., Lopez, A., Ramos-Gomez, L., De La Torre-Prados, V., Pellejero, R., Laloe, V., Mandrella, B., Suganthan, Perera, S., Mahendran, K., Stocker, R., Ludwig, S., Zimmermann, H., Denzler, U., Yutthakasemsunt, S., Kittiwattanagul, W., Watanachai, C., Subsompon, P., Pussanakawatin, W., Khunjan, P., Tangchitvittaya, S., Nilapong, S., Klangsang, T., Taechakosol, W., Srinat, A., Jerbi, Z., Borsali-Falfoul, N., Rezgui, M., Cakar, N., Ssenyonjo, H., Kobusingye, O., Lomas, G., Yates, D., Lecky, F., Bleetman, A., Baldwin, A., Jenkinson, E., Pantrini, S., Stewart, J., Contractor, N., Roberts, T., Butler, J., Pinto, A., Lee, D., Brayley, N., Robbshaw, K., Dix, C., Graham, S., Pye, S., Green, M., Kellins, A., Moulton, C., Fogg, B., Cottingham, R., Funnell, S., Shanker, U., Summers, C., Malek, L., Ashcroft, C., Powell, J., Moore, S., Buckley, S., Grocutt, M., Chambers, S., Morrice, A., Marshall, H., Harris, J., Matthews, W., Tippet, J., Mardell, S., Macmillan, F., Shaw, A., Luthra, P., Dixon, G., Ahmed, M., Young, M., Mason, S., Loveday, I., Clark, C., Taylor, S., Wilson, P., Ali, K., Greenwood, S., White, M., Perez, R., Eljamel, S., Wasserberg, J., Shale, H., Read, C., Mccarron, J., Pennell, A., Ray, G., Thurston, J., Brown, E., Jaffey, L., Graves, M., Bailey, R., Loveridge, N., Evans, G., Hughes, S., Richardson, J., Gallagher, C., Odedun, T., Lees, K., Foley, D., Payne, N., Pennycook, A., Griffiths, C., Moore, D., Byrne, D., Dasan, S., Banerjee, Abhishek, Mcguinness, S., Chikhani, C., Zoltie, N., Barlow, I., Stell, I., Hulse, W., Crossley, J., Watkins, L., Dorani, B., Vanviet, T., Saladino, P., Cabrera, A., Baigent, C., Bracken, M., Chadwick, D., Curley, K., Duley, L., Farrell, B., Haegi, M., Nickson, G., Peto, R., Pickard, J., Roberts, I., Sandercock, P., Teasdale, G., Collins, R., Haines, S., Macmahon, S., Warlow, C., Edwards, P., Ritchie, N., Shakur, H., Ramos, M., Barnetson, L., Fernandes, J., Tooth, D., Free, C., Narayanan, L., Collander, J., Abernethy, J., Bardswell, J., Mashru, R., Godward, C., Afolabi, L., Ritchie, A., Hosford, T., Collingwood, A., Massey, S., Plata R., Annetta M. (ORCID:0000-0001-7574-1311), Banerjee A., Olldashi, F., Muzha, I., Filipi, N., Lede, R., Copertari, P., Traverso, C., Copertari, A., Vergara, E. A., Montenegro, C., De Huidobro, R. R., Surt, K., Cialzeta, J., Lazzeri, S., Pinero, G., Ciccioli, F., Videtta, W., Barboza, M. F., Svampa, S., Sciuto, V., Domeniconi, G., Bustamante, M., Waschbusch, M., Gullo, M. P., Drago, D. A., Linares, J. C. A., Camputaro, L., Troccoli, G., Galimberti, H., Tallott, M., Eybner, C., Buchinger, W., Fitzal, S., Mazairac, G., Oleffe, V., Grollinger, T., Delvaux, P., Carlier, L., Braet, V., Jacques, J. -M., De Knoop, D., Nasi, L., Choi, H. K., Schmitt, M., Gentil, A., Nacul, F., Barrios, P. B., Xinkang, C., Hua, L. S., Tian, H. H., Xiaodong, C., Gualteros, W., Otero, A. A., Arango, M., Ciro, J., Jaramillo, H., Garcia, G., Gonzalez, I., Gomez, C., Arias, A., Fonseca, M., Mora, C., Cabrera, E. G. L., Betancurth, J. L., Munoz, P., Quinonez, J. A., Castillo, M. E. G., Lopez, O., Yepes, R. P., Cuellar, D. L., Paez, G., Chaves, H. D., Ordonez, P. E., Plata, Riccardo, Pineda, M., Pulido, L. E., Jaramillo, J. S. V., Rebolledo, C., Palma, O., Soler, C., Pastrana, I., Falero, R., Perera, M. D., Garcia, A. A., Oliva, R., Delgado, H. L., Carnero, A. M., Lopez, B. L., Gallardo, A. L., Morales, A. O., Lezcano, H., Ferrer, M. I., Bess, I. Z., Canino, G. R., Ruiz, E. M. P., Cruz, O. G., Svoboda, P., Kantorova, I., Ochmann, J., Scheer, P., Kozumplik, L., Marsova, J., Edelmann, K., Chytra, I., Bosman, R., Andrejsova, H., Pachl, J., Burger, J., Kramar, F., Ulloa, M. I., Gonzalez, L., Daccach, A., Ortega, A., Cevallos, S., Cueva, B. Z., Ochoa, M., Tapia, J. V., Hurtado, J., Wong, M. C. S., Santos, R., Khamis, H., Abaza, A. H., Fekry, A., El Kordy, S., Shawky, T., El-Sayed, H., Khalil, N., Negm, N., Fisal, S., Shokry, H., Alamin, M., Elhusseny, A. Y., Radwan, A., Rashid, M., Gogichaisvili, T., Ingorokva, G., Gongadze, N., Otarashvili, A., Kleist, W., Kalkum, M., Ulrich, P., Andrews, N., Nakos, G., Karavelis, A., Archontakis, G., Myrianthefs, P., Yadav, Y., Yadav, S., Khatri, R., Baghel, A., Husain, M., Jha, D., Hoong Chhang, W., Dhandhania, M., Fonning, C., Iyengar, S. N., Gupta, S., Ravi, R. R., Bopiah, K. S., Herur, A., Venkataramana, N. K., Satish, A., Bhavadasan, K., Morris, R., Ramesh, S., Dewan, Y., Singh, Y., Bhagchandani, R., Bhagchandani, S., Sethurayar, V., Ipe, S., Sreekumar, G., Panigrahi, M., Reddy, A., Khosla, V., Pillay, H., Thomas, N., Sridhar, K., Jose, B., Kurian, N., Praharaj, S., Pillai, S., Ramana, Kiyawat, D., Maheshwari, K., Panikar, D., Chawla, J., Shenoy, S., Raja, A., Rupayana, Y., Reddy, S., Mohan, N., Kelkar, S., Johri, M., Golden, N., Maliawan, S., Fauzi, A., Farouk, U., Fakharian, E., Aramesh, A., Eghtedari, M., Ahmadzadeh, F., Gholami, A., Plunkett, P., Redican, C., Mcmahon, G., Annetta, Maria Giuseppina, Mouchaty, H., Bruzzone, E., Harding, B., Qureshi, M., Idris, Z., Abdullah, J., Ghazali, G., Ghani, A., Cheah, F., Gonzalez, J., Loria-Castellanos, J., Jackson, S., Hutchinson, R., Komolafe, E., Adeolu, A., Komolafe, M., Adeyemi-Doro, O., Bankole, F., Shehu, B., Danlami, V., Odebode, O., Oluwadiya, K., Sanni, A., Giebel, H., Kumar, S., Jooma, R., Mezquita, J., Ortiz Ovelar, C., Gonzales-Portillo, M., Rodriguez, D., Balica, L., Oprita, B., Sklerniacof, M., Steflea, L., Bandut, L., Danil, A., Iliescu, R., Ciurea, J., El-Dawlatly, A., Alwatidy, S., Al-Yafi, W., El-Dawlatly, M., Krunic-Protic, R., Janosevic, V., Tan, J., Seah, C., Trenkler, S., Humenansky, M., Stajancova, T., Schwendt, I., Laincz, A., Julius, Z., Maros, S., Firment, J., Cifranicova, M., Saniova, B., Kalig, K., Medekova, S., Wiszt, R., Macsuga, I., Hartzenberg, B., Du Plessis, G., Houlie, Z., Nathoo, N., Khumalo, S., Tracey, R., Munoz-Sanchez, A., Murillo-Cabezas, F., Flores-Cordero, J., Rincon-Ferrari, D., Rubi, M., Caler, L., Del Campo, M., Laguna, L., Manuel Nava, J., Minguillon, M., Lopez, A., Ramos-Gomez, L., De La Torre-Prados, V., Pellejero, R., Laloe, V., Mandrella, B., Suganthan, Perera, S., Mahendran, K., Stocker, R., Ludwig, S., Zimmermann, H., Denzler, U., Yutthakasemsunt, S., Kittiwattanagul, W., Watanachai, C., Subsompon, P., Pussanakawatin, W., Khunjan, P., Tangchitvittaya, S., Nilapong, S., Klangsang, T., Taechakosol, W., Srinat, A., Jerbi, Z., Borsali-Falfoul, N., Rezgui, M., Cakar, N., Ssenyonjo, H., Kobusingye, O., Lomas, G., Yates, D., Lecky, F., Bleetman, A., Baldwin, A., Jenkinson, E., Pantrini, S., Stewart, J., Contractor, N., Roberts, T., Butler, J., Pinto, A., Lee, D., Brayley, N., Robbshaw, K., Dix, C., Graham, S., Pye, S., Green, M., Kellins, A., Moulton, C., Fogg, B., Cottingham, R., Funnell, S., Shanker, U., Summers, C., Malek, L., Ashcroft, C., Powell, J., Moore, S., Buckley, S., Grocutt, M., Chambers, S., Morrice, A., Marshall, H., Harris, J., Matthews, W., Tippet, J., Mardell, S., Macmillan, F., Shaw, A., Luthra, P., Dixon, G., Ahmed, M., Young, M., Mason, S., Loveday, I., Clark, C., Taylor, S., Wilson, P., Ali, K., Greenwood, S., White, M., Perez, R., Eljamel, S., Wasserberg, J., Shale, H., Read, C., Mccarron, J., Pennell, A., Ray, G., Thurston, J., Brown, E., Jaffey, L., Graves, M., Bailey, R., Loveridge, N., Evans, G., Hughes, S., Richardson, J., Gallagher, C., Odedun, T., Lees, K., Foley, D., Payne, N., Pennycook, A., Griffiths, C., Moore, D., Byrne, D., Dasan, S., Banerjee, Abhishek, Mcguinness, S., Chikhani, C., Zoltie, N., Barlow, I., Stell, I., Hulse, W., Crossley, J., Watkins, L., Dorani, B., Vanviet, T., Saladino, P., Cabrera, A., Baigent, C., Bracken, M., Chadwick, D., Curley, K., Duley, L., Farrell, B., Haegi, M., Nickson, G., Peto, R., Pickard, J., Roberts, I., Sandercock, P., Teasdale, G., Collins, R., Haines, S., Macmahon, S., Warlow, C., Edwards, P., Ritchie, N., Shakur, H., Ramos, M., Barnetson, L., Fernandes, J., Tooth, D., Free, C., Narayanan, L., Collander, J., Abernethy, J., Bardswell, J., Mashru, R., Godward, C., Afolabi, L., Ritchie, A., Hosford, T., Collingwood, A., Massey, S., Plata R., Annetta M. (ORCID:0000-0001-7574-1311), and Banerjee A.

Abstract

Background Corticosteroids have been used to treat head injuries for more than 30 years. In 1997, findings of a systematic review suggested that these drugs reduce risk of death by 1-2%. The CRASH trial—a multicentre international collaboration—aimed to confirm or refute such an effect by recruiting 20 000 patients. In May, 2004, the data monitoring committee disclosed the unmasked results to the steering committee, which stopped recruitment. Methods 10 008 adults with head injury and a Glasgow coma score (GCS) of 14 or less within 8 h of injury were randomly allocated 48 h infusion of corticosteroids (methylprednisolone) or placebo. Primary outcomes were death within 2 weeks of injury and death or disability at 6 months. Prespecified subgroup analyses were based on injury severity (GCS) at randomisation and on time from injury to randomisation. Analysis was by intention to treat. Effects on outcomes within 2 weeks of randomisation are presented in this report. This study is registered as an International Standard Randomised Controlled Trial, number ISRCTN74459797. Findings Compared with placebo, the risk of death from all causes within 2 weeks was higher in the group allocated corticosteroids (1052 [21·1%] vs 893 [17·9%] deaths; relative risk 1·18 [95% CI 1·09-1·27]; p=0·0001). The relative increase in deaths due to corticosteroids did not differ by injury severity (p=0·22) or time since injury (p=0·05). Interpretation Our results show there is no reduction in mortality with methylprednisolone in the 2 weeks after head injury. The cause of the rise in risk of death within 2 weeks is unclear.

Published
2004

23. Polimorfismo P.D1134A del gen TJP1 en población con ancestría zapoteca; potencial marcador para cáncer de tiroides y otras neoplasias.

Author

Madrigal-Ruiz, P., Dávalos-Rodríguez, N. O., Ramírez-García, S. A., Topete-González, L. R., Mazariegos-Rubi, M., Flores-Alvarado, L. J., Ruiz-Mejia, R., Aguilar-Aldrete, M. E., Magallanes-Ordoñez, J. J., Ramón-Canul, L. G., Siliceo-Murrieta, J. I., Zurita-Vásquez, G. G., and Cruz-Bastida, J. M.

Abstract

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Published
2015

27. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2) a randomised, placebo-controlled trial

Author

Olldashi, F., Kerçi, M., Zhurda, T., Ruçi, K., Banushi, A., Traverso, M. S., Jiménez, J., Balbi, J., Dellera, C., Svampa, S., Quintana, G., Piñero, G., Teves, J., Seppelt, I., Mountain, D., Balogh, Z., Zaman, M., Druwé, P., Rutsaert, R., Mazairac, G., Pascal, F., Yvette, Z., Chancellin, D., Okwen, P., Djokam-Liapoe, J., Jangwa, E., Mbuagbaw, L., Fointama, N., Pascal, N., Baillie, F., Jiang, J. -Y, Gao, G. -Y, Bao, Y. -H, Morales, C., Sierra, J., Naranjo, S., Correa, C., Gómez, C., Herrera, J., Caicedo, L., Rojas, A., Pastas, H., Miranda, H., Constaín, A., Perdomo, M., Muñoz, D., Duarte, Á, Vásquez, E., Ortiz, C., Ayala, B., Delgado, H., Benavides, G., Rosero, L., Mejía-Mantilla, J., Varela, A., Calle, M., Castillo, J., García, A., Ciro, J., Villa, C., Panesso, R., Flórez, L., Gallego, A., Puentes-Manosalva, F., Medina, L., Márquez, K., Romero, A. R., Hernández, R., Martínez, J., Gualteros, W., Urbina, Z., Velandia, J., Benítez, F., Trochez, A., Villarreal, A., Pabón, P., López, H., Quintero, L., Rubiano, A., Tamayo, J., Piñera, M., Navarro, Z., Rondón, D., Bujan, B., Palacios, L., Martínez, D., Hernández, Y., Fernández, Y., Casola, E., Delgado, R., Herrera, C., Arbolaéz, M., Domínguez, M., Iraola, M., Rojas, O., Enseñat, A., Pastrana, I., Rodríguez, D., La Campa, S. Á, Fortún, T., Larrea, M., Aragón, L., Madrazo, A., Svoboda, P., Izurieta, M., Daccach, A., Altamirano, M., Ortega, A., Cárdenas, B., González, L., Ochoa, M., Ortega, F., Quichimbo, F., Guiñanzaca, J., Zavala, I., Segura, S., Jerez, J., Acosta, D., Yánez, F., Camacho, R., Khamis, H., Shafei, H., Kheidr, A., Nasr, H., Mosaad, M., Rizk, S., El Sayed, H., Moati, T., Hokkam, E., Amin, M., Lowis, H., Fawzy, M., Bedir, N., Aldars, M., Rodríguez, V., Tobar, J., Alvarenga, J., Shalamberidze, B., Demuria, E., Rtveliashvili, N., Chutkerashvili, G., Dotiashvili, D., Gogichaishvili, T., Ingorokva, G., Kazaishvili, D., Melikidze, B., Iashvili, N., Tomadze, G., Chkhikvadze, M., Khurtsidze, L., Lomidze, Z., Dzagania, D., Kvachadze, N., Gotsadze, G., Kaloiani, V., Kajaia, N., Dakubo, J., Naaeder, S., Sowah, P., Yusuf, A., Ishak, A., Selasi-Sefenu, P., Sibiri, B., Sarpong-Peprah, S., Boro, T., Bopaiah, K., Shetty, K., Subbiah, R., Mulla, L., Doshi, A., Dewan, Y., Grewal, S., Tripathy, P., Mathew, J., Gupta, B., Lal, A., Choudhury, M., Gupta, S., Chug, A., Pamidimukkala, V., Jagannath, P., Maharaj, M., Vommi, R., Gudipati, N., Chhang, W. H., Patel, P., Suthar, N., Banker, D., Patel, J., Dharap, S., Kamble, R., Patkar, S., Lohiya, S., Saraf, R., Kumar, D., Parihar, S., Gupta, R., Mangual, R., Alagumuthu, Kooper, D., Mohapatra, C., David, S., Rajaleelan, W., Pangi, A., Saraf, V., Chikareddy, S., Mankar, S., Golhar, A., Sakhare, R., Wagh, N., Hazarika, D., Chaudhuri, P., Ketan, P., Purohit, G., Purohit, Y., Pandya, M., Kiran, S., Walia, S., Goyal, S., Attri, A., Sharma, R., Oberai, A., Oberai, M., Oberoi, S., Tripathi, G. K., Peettakkandy, V., Karuthillath, P., Vadakammuriyil, P., Pol, J., Pol, S., Saste, M., Raul, S., Tiwari, S., Nelly, N., Chidambaram, M., Kollengode, V., Thampan, S., Rajan, S., Raju, S., Babu, S. V., Sumathi, C., Chatterjee, P., Agarwal, A., Magar, H., Magar, M., Singh, M., Gupta, D., Haloi, K., Sagdeo, V., Giri, P., Verma, N., Jariwala, R., Goti, A., Prabhu-Gaonkar, A., Utagi, S., Joshi, M., Agrawal, R., Sharma, G., Saini, G., Tewari, V., Yadav, Y., Parihar, V., Venkataramana, N., Rao, S., Reddy, N., Chander, S. G., Hathila, V., Das, V., Agaja, K., Purohit, A., Lahari, A., Bhagchandani, R., Vidyasagar, B., Sachan, P. K., Das, T., Vyas, S., Bhattacharjee, S., Sancheti, P., Manoj, T., Moideen, M., Pansey, K., Chandrasekaran, V. P., Saikia, K., Tata, H., Vhora, S., Shah, A., Rangad, G., Rajasekaran, S., Shankarlal, S. T., Devadoss, S., Saleem, M., Pillay, H., Hazarika, Z., Deshmukh, P., Murugappan, S. P., Jaiswal, A., Vangani, D., Modha, P., Chonzik, C., Praveen, M., Sethurayar, V., Ipe, S., Shetty, N., Gupta, R. P., Jain, V., Shah, K., Dwikoryanto, M., Golden, N., Atmadjaya, K., Wiargitha, K., Sudiasa, K., Suwedagatha, G., Bal Afif, F., Budipramana, V., Tabrani, Lemuel, A., Chandra, S., Ama, F., Sherafatkazemzadeh, E., Moradi, E., Sheikhi, A., Ziaee, A., Fanaei, A., Hajinasrollah, E., Amini, A., Mohammad, B., Hadi, N., Perone, G., Peri, E., Volpi, A., Johnson, J., Abe, M., Mutiso, V., Okanga, B., Ojuka, D., Abdullah, B., Rahman, H., Noh, Y., Jamaluddin, S., Dawal, H., Roslani, A., Law, C. -W, Devashanti, P., Wahab, Y., Velaiutham, S., Dato, R., Loría, J., Montes, E., Gómez, E., Cazales, V., Bautista, P., Bautista, R., Ahumada, D., Hernández, E., Velásquez, G., Ortega, P., Lira, G., Estrada, F., Casasola, J., Olaomi, O., Abubakar, Y., Apollo, K., Badejo, O., Ihekire, O., Iribhogbe, P., Oludiran, O., Obeta, E., Okojie, C., Udefiagbon, E., Komolafe, E., Olaleye, P., Uzochukwu, T., Onakpoya, U., Dongo, A., Uhunmwagho, O., Eighemerio, E., Morgan, E., Thanni, L., Afolabi, A., Akinola, T., Ademola, A., Akute, O., Khalid, L., Abubakar, L., Aminu, M., Ogirima, M., Attansey, A., Michael, D., Aremu, O., Olugbenga, O., Ukpong, U., Salman, Y., Obianyo, N., Ani, C., Ezeadawi, R., Kehinde, O., Olaide, A., Jogo, A., Bitto, T., Anyanwu, S., Mbonu, O., Oludara, M., Somoye, M., Shehu, B., Ismail, N., Katchy, A., Ndoma-Egba, R., Grace-Inah, N., Songden, Z., Abdulraheem, A., Otu, A., Nottidge, T., Inyang, D., Idiapho, D., Giebel, H., Hassan, R., Adisa, A., Akinkuolie, A., Okam, K., Musa, A., Falope, I., Eze, J., Caballero, J., Azabache, W., Salirrosas, O., Soto, A., Torres, E., Ramírez, G., Malca, C., Velez, J., Yepez, R., Yupanqui, H., Lagos, P., Rodriguez, D., Flores, J., Moya, A., Barrionuevo, A., Gonzales-Portillo, M., Nunez, E., Eldawlatly, A., Al Naami, M., Delvi, B., Khalid, K., Alyafi, W., Djurovic, B., Ng, I., Yaghi, A., Laincz, A., Trenkler, S., Valky, J., Modiba, M., Legodi, P., Rangaka, T., Wallis, L., Muñoz, Á, Serrano, A., Misis, M., Rubi, M., La Torre, V., Ellawala, R., Wijeratna, S., Gunaratna, L., Wijayanayaka, C., Nungu, K., Billy Haonga, Mtapa, G., Yutthakasemsunt, S., Kittiwattanagul, W., Piyavechvirat, P., Impool, T., Thummaraj, S., Salaeh, R., Tangchitvittaya, S., Wattanakrai, K., Soonthornthum, C., Jiravongbunrod, T., Meephant, S., Subsompon, P., Pensuwan, P., Chamnongwit, W., Jerbi, Z., Cherif, A., Nash, M., Harris, T., Banerjee, J., Freij, R., Kendall, J., Moore, S., Townend, W., Cottingham, R., Becker, D., Lloyd, S., Burdett-Smith, P., Mirza, K., Webster, A., Brady, S., Grocutt, A., Thurston, J., Lecky, F., Goodacre, S., Mulla, Y., Sakala, D., and Chengo, C.

30. A Thermodynamic Description of Active Transport

Author

Kjelstrup, S., Rubi, J.M., Bedeaux, D., Beiglböck, Wolf, editor, Ehlers, Jürgen, editor, Hepp, Klaus, editor, Weidenmüller, Hans A., editor, Beig, R., editor, Domcke, W., editor, Englert, B.-G., editor, Frisch, U., editor, Hänggi, P., editor, Hasinger, G., editor, Hillebrandt, W., editor, Jaffe, R. L., editor, Janke, W., editor, Löhneysen, H. von, editor, Mangano, M., editor, Raimond, J.-M., editor, Sornette, D., editor, Theisen, S., editor, Weise, W., editor, Zittartz, J., editor, Franzese, G., editor, and Rubi, M., editor

Published
2008
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31. Energy Interconversion in Transport ATPases Role of Water in Ions Transport and in the Energy of Hydrolysis of Phosphate Compounds

Author

de Meis, L., Beiglböck, Wolf, editor, Ehlers, Jürgen, editor, Hepp, Klaus, editor, Weidenmüller, Hans A., editor, Beig, R., editor, Domcke, W., editor, Englert, B.-G., editor, Frisch, U., editor, Hänggi, P., editor, Hasinger, G., editor, Hillebrandt, W., editor, Jaffe, R. L., editor, Janke, W., editor, Löhneysen, H. von, editor, Mangano, M., editor, Raimond, J.-M., editor, Sornette, D., editor, Theisen, S., editor, Weise, W., editor, Zittartz, J., editor, Franzese, G., editor, and Rubi, M., editor

Published
2008
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32. Activity-Dependent Model for Neuronal Avalanches

Author

de Arcangelis, L., Beiglböck, Wolf, editor, Ehlers, Jürgen, editor, Hepp, Klaus, editor, Weidenmüller, Hans A., editor, Beig, R., editor, Domcke, W., editor, Englert, B.-G., editor, Frisch, U., editor, Hänggi, P., editor, Hasinger, G., editor, Hillebrandt, W., editor, Jaffe, R. L., editor, Janke, W., editor, Löhneysen, H. von, editor, Mangano, M., editor, Raimond, J.-M., editor, Sornette, D., editor, Theisen, S., editor, Weise, W., editor, Zittartz, J., editor, Franzese, G., editor, and Rubi, M., editor

Published
2008
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33. Metastable Mesoscopic Phases in Concentrated Protein Solutions

Author

Vekilov, P.G., Pan, W., Gliko, O., Katsonis, P., Galkin, O., Beiglböck, Wolf, editor, Ehlers, Jürgen, editor, Hepp, Klaus, editor, Weidenmüller, Hans A., editor, Beig, R., editor, Domcke, W., editor, Englert, B.-G., editor, Frisch, U., editor, Hänggi, P., editor, Hasinger, G., editor, Hillebrandt, W., editor, Jaffe, R. L., editor, Janke, W., editor, Löhneysen, H. von, editor, Mangano, M., editor, Raimond, J.-M., editor, Sornette, D., editor, Theisen, S., editor, Weise, W., editor, Zittartz, J., editor, Franzese, G., editor, and Rubi, M., editor

Published
2008
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34. Cooperative Effects in Biological Suspensions: From Filaments to Propellers

Author

Pagonabarraga, I., Llopis, I., Beiglböck, Wolf, editor, Ehlers, Jürgen, editor, Hepp, Klaus, editor, Weidenmüller, Hans A., editor, Beig, R., editor, Domcke, W., editor, Englert, B.-G., editor, Frisch, U., editor, Hänggi, P., editor, Hasinger, G., editor, Hillebrandt, W., editor, Jaffe, R. L., editor, Janke, W., editor, Löhneysen, H. von, editor, Mangano, M., editor, Raimond, J.-M., editor, Sornette, D., editor, Theisen, S., editor, Weise, W., editor, Zittartz, J., editor, Franzese, G., editor, and Rubi, M., editor

Published
2008
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35. A Novel Mechanism for Activator-Controlled Initiation of DNA Replication that Resolves the Auto-regulation Sequestration Paradox

Author

Nilsson, K., Ehrenberg, M., Beiglböck, Wolf, editor, Ehlers, Jürgen, editor, Hepp, Klaus, editor, Weidenmüller, Hans A., editor, Beig, R., editor, Domcke, W., editor, Englert, B.-G., editor, Frisch, U., editor, Hänggi, P., editor, Hasinger, G., editor, Hillebrandt, W., editor, Jaffe, R. L., editor, Janke, W., editor, Löhneysen, H. von, editor, Mangano, M., editor, Raimond, J.-M., editor, Sornette, D., editor, Theisen, S., editor, Weise, W., editor, Zittartz, J., editor, Franzese, G., editor, and Rubi, M., editor

Published
2008
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36. Application of Discrete Molecular Dynamics to Protein Folding and Aggregation

Author

Buldyrev, S. V., Beiglböck, Wolf, editor, Ehlers, Jürgen, editor, Hepp, Klaus, editor, Weidenmüller, Hans A., editor, Beig, R., editor, Domcke, W., editor, Englert, B.-G., editor, Frisch, U., editor, Hänggi, P., editor, Hasinger, G., editor, Hillebrandt, W., editor, Jaffe, R. L., editor, Janke, W., editor, Löhneysen, H. von, editor, Mangano, M., editor, Raimond, J.-M., editor, Sornette, D., editor, Theisen, S., editor, Weise, W., editor, Zittartz, J., editor, Franzese, G., editor, and Rubi, M., editor

Published
2008
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37. Anomalous Behaviour of Supercooled Water and Its Implication for Protein Dynamics

Author

Swenson, J., Jansson, H., Bergman, R., Beiglböck, Wolf, editor, Ehlers, Jürgen, editor, Hepp, Klaus, editor, Weidenmüller, Hans A., editor, Beig, R., editor, Domcke, W., editor, Englert, B.-G., editor, Frisch, U., editor, Hänggi, P., editor, Hasinger, G., editor, Hillebrandt, W., editor, Jaffe, R. L., editor, Janke, W., editor, Löhneysen, H. von, editor, Mangano, M., editor, Raimond, J.-M., editor, Sornette, D., editor, Theisen, S., editor, Weise, W., editor, Zittartz, J., editor, Franzese, G., editor, and Rubi, M., editor

Published
2008
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38. Dynamics of Water at Low Temperatures and Implications for Biomolecules

Author

Kumar, P., Franzese, G., Buldyrev, S.V., Stanley, H.E., Beiglböck, Wolf, editor, Ehlers, Jürgen, editor, Hepp, Klaus, editor, Weidenmüller, Hans A., editor, Beig, R., editor, Domcke, W., editor, Englert, B.-G., editor, Frisch, U., editor, Hänggi, P., editor, Hasinger, G., editor, Hillebrandt, W., editor, Jaffe, R. L., editor, Janke, W., editor, Löhneysen, H. von, editor, Mangano, M., editor, Raimond, J.-M., editor, Sornette, D., editor, Theisen, S., editor, Weise, W., editor, Zittartz, J., editor, Franzese, G., editor, and Rubi, M., editor

Published
2008
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39. Interactions of Polarizable Media inWater and the Hydrophobic Interaction

Author

Bresme, F., Wynveen, A., Beiglböck, Wolf, editor, Ehlers, Jürgen, editor, Hepp, Klaus, editor, Weidenmüller, Hans A., editor, Beig, R., editor, Domcke, W., editor, Englert, B.-G., editor, Frisch, U., editor, Hänggi, P., editor, Hasinger, G., editor, Hillebrandt, W., editor, Jaffe, R. L., editor, Janke, W., editor, Löhneysen, H. von, editor, Mangano, M., editor, Raimond, J.-M., editor, Sornette, D., editor, Theisen, S., editor, Weise, W., editor, Zittartz, J., editor, Franzese, G., editor, and Rubi, M., editor

Published
2008
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40. An ideal glass transition in supercooled water?

Author

Paola Gallo, Francesco Sciortino, Sow-Hsin Chen, Piero Tartaglia, Sciortino, F and Chen, SH and Gallo, P and Tartaglia, P, Rubi M, Perez-Vincente C, Scioritno, F, Chen, Sh, Gallo, Paola, and Tartaglia, P.

Subjects
Condensed Matter::Soft Condensed Matter, Physics, Molecular dynamics, Singularity, Ideal (set theory), Mode coupling, Thermodynamics, Viscous liquid, Kinetic energy, Supercooling, Glass transition
Abstract

Analyzing recent molecular dynamics simulations in deeply supercooled liquid states, we have found that the single particle dynamics in water can be interpreted in terms of Mode Coupling Theory, in its so-called ideal formulation. In this paper we review such evidence and discuss the relevance of this finding for the debated thermodynamic behavior of supercooled water. The experimental apparent power-law behavior of the transport coefficients in water, diverging or going to zero at the so-called Angell temperature could indeed be interpreted as a kinetic, as distinct from thermodynamic, phenomena. This finding removes the need of a thermodynamic singularity for the explanation of the anomalies of liquid water. We also comment on the development of a significant harmonic dynamics on cooling the liquid, which could indicate a transition from a fragile to a strong behavior in liquid water.

Published
2008

41. On the microscopic theory of phase coexistence

Author

Salvador Miracle Solé, Miracle-Sole, Salvador, J.J. Brey, J. Marro, J.M. Rubi, M. San Miguel (Eds.), Centre de Physique Théorique - UMR 7332 (CPT), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), J.J. Brey, J. Marro, J.M. Rubi, and M. San Miguel (Eds.)

Subjects
Materials science, Condensed matter physics, equilibrium crystals, step free energy, Correlation inequality, Gibbs state, 01 natural sciences, interfaces, Crystal, Surface tension, [PHYS.COND.CM-SM] Physics [physics]/Condensed Matter [cond-mat]/Statistical Mechanics [cond-mat.stat-mech], Lattice (module), [MATH.MATH-MP]Mathematics [math]/Mathematical Physics [math-ph], surface tension, Phase (matter), 0103 physical sciences, Lattice systems, Ising model, 010307 mathematical physics, [PHYS.COND.CM-SM]Physics [physics]/Condensed Matter [cond-mat]/Statistical Mechanics [cond-mat.stat-mech], [MATH.MATH-MP] Mathematics [math]/Mathematical Physics [math-ph], Microscopic theory, 010306 general physics
Abstract

International audience; Some rigorous results concerning the microscopic theory of interfaces and crystal shapes in classical lattice systems are reported.

Published
2008

42. Co-design of experimental nature-based solutions for decentralized dry-weather runoff treatment retrofitted in a densely urbanized area in Central America.

Author

Pérez Rubi M and Hack J

Subjects
Central America, Cities, Costa Rica, Water Movements, Weather, Ecosystem, Rain
Abstract

The quality of water in many urban rivers in Latin America is increasingly degrading due to wastewater and runoff discharges from urban sprawl. Due to deficits in sanitary drainage systems, greywater is discharged to the stormwater drainage network generating a continuous dry-weather runoff that reaches rivers without treatment. One of the main challenges in the region is to achieve sustainable management of urban runoff for the recovery of rivers ecosystem integrity. However, retrofitting conventional centralized wastewater drainage networks into the existing urban grid represents important social, economic and technical challenges. This paper presents an alternative adaptive methodology for the design of Nature-based Solutions for decentralized urban runoff treatment. Through this study, technical solutions commonly used for stormwater management were adapted for dry-weather runoff treatment and co-designed for the particular conditions of a representative study area, considering space availability as the main constraining factor for retrofitting in urban areas. The application of a co-design process in a dense neighbourhood of the Great Metropolitan area of Costa Rica brought to light valuable insights about conditions that could be hindering the implementation of NBS infrastructures in Latin America.

Published
2021
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43. Ouabain Enhances Gap Junctional Intercellular Communication by Inducing Paracrine Secretion of Prostaglandin E2.

Author

Ogazon Del Toro A, Jimenez L, Serrano Rubi M, Cereijido M, and Ponce A

Subjects
Animals, Dogs, Madin Darby Canine Kidney Cells, Signal Transduction, Cardiotonic Agents pharmacology, Dinoprostone metabolism, Gap Junctions physiology, Ouabain pharmacology, Paracrine Communication
Abstract

Ouabain is a cardiac glycoside that has been described as a hormone, with interesting effects on epithelial physiology. We have shown previously that ouabain induces gap junctional intercellular communication (GJIC) in wild, sensitive cells (MDCK-S), but not in cells that have become insensitive (MDCK-I) by modifying their Na + -K + -ATPase. We have also demonstrated that prostaglandin E2 (PGE2) is able to induce increased GJIC by a mechanism other than ouabain, that does not depend on Na + -K + -ATPase. In this work we show, by dye transfer assays, that when MDCK-S and MDCK-I are randomly mixed, to form monolayers, the latter stablish GJIC, because of stimulation by a compound released to the extracellular media, by MDCK-S cells, after treatment with ouabain, as evidenced by the fact that monolayers of only MDCK-I cells, treated with a conditioned medium (CM) that is obtained after incubation of MDCK-S monolayers with ouabain, significantly increase their GJIC. The further finding that either (1) pre-treatment with COX-2 inhibitors or (2) addition to CM of antagonists of EP2 receptor abolish CM's ability to induce GJIC in MDCK-I monolayers indicate that PGE2 is the GJIC-inducing compound. Therefore, these results indicate that, in addition to direct stimulation, mediated by Na + -K + -ATPase, ouabain enhances GJIC indirectly through the paracrine production of PGE2.

Published
2021
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44. Prostaglandin E2 Enhances Gap Junctional Intercellular Communication in Clonal Epithelial Cells.

Author

Ogazon Del Toro A, Jimenez L, Serrano Rubi M, Castillo A, Hinojosa L, Martinez Rendon J, Cereijido M, and Ponce A

Subjects
Adenylyl Cyclases metabolism, Animals, Cyclic AMP metabolism, Cyclic AMP-Dependent Protein Kinases metabolism, Dogs, Dose-Response Relationship, Drug, Epithelial Cells cytology, Epithelial Cells metabolism, Gap Junctions metabolism, Madin Darby Canine Kidney Cells, Receptors, Prostaglandin E, EP2 Subtype metabolism, Signal Transduction drug effects, Time Factors, Cell Communication drug effects, Dinoprostone pharmacology, Epithelial Cells drug effects, Gap Junctions drug effects
Abstract

Prostaglandins are a group of lipids that produce diverse physiological and pathological effects. Among them, prostaglandin E2 (PGE2) stands out for the wide variety of functions in which it participates. To date, there is little information about the influence of PGE2 on gap junctional intercellular communication (GJIC) in any type of tissue, including epithelia. In this work, we set out to determine whether PGE2 influences GJIC in epithelial cells (MDCK cells). To this end, we performed dye (Lucifer yellow) transfer assays to compare GJIC of MDCK cells treated with PGE2 and untreated cells. Our results indicated that (1) PGE2 induces a statistically significant increase in GJIC from 100 nM and from 15 min after its addition to the medium, (2) such effect does not require the synthesis of new mRNA or proteins subunits but rather trafficking of subunits already synthesized, and (3) such effect is mediated by the E2 receptor, which, in turn, triggers a signaling pathway that includes activation of adenylyl cyclase and protein kinase A (PKA). These results widen the knowledge regarding modulation of gap junctional intercellular communication by prostaglandins.

Published
2021
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45. Ouabain Promotes Gap Junctional Intercellular Communication in Cancer Cells.

Author

Serrano-Rubi M, Jimenez L, Martinez-Rendon J, Cereijido M, and Ponce A

Subjects
Apoptosis, Cell Proliferation, Humans, Neoplasms drug therapy, Neoplasms metabolism, Signal Transduction, Tumor Cells, Cultured, Cardiotonic Agents pharmacology, Cell Communication, Gap Junctions drug effects, Neoplasms pathology, Ouabain pharmacology
Abstract

Gap junctions are molecular structures that allow communication between neighboring cells. It has been shown that gap junctional intercellular communication (GJIC) is notoriously reduced in cancer cells compared to their normal counterparts. Ouabain, a plant derived substance, widely known for its therapeutic properties on the heart, has been shown to play a role in several types of cancer, although its mechanism of action is not yet fully understood. Since we have previously shown that ouabain enhances GJIC in epithelial cells (MDCK), here we probed whether ouabain affects GJIC in a variety of cancer cell lines, including cervico-uterine (CasKi, SiHa and Hela), breast (MDA-MB-321 and MCF7), lung (A549), colon (SW480) and pancreas (HPAF-II). For this purpose, we conducted dye transfer assays to measure and compare GJIC in monolayers of cells with and without treatment with ouabain (0.1, 1, 10, 50 and 500 nM). We found that ouabain induces a statistically significant enhancement of GJIC in all of these cancer cell lines, albeit with distinct sensitivity. Additionally, we show that synthesis of new nucleotides or protein subunits is not required, and that Csrc, ErK1/2 and ROCK-Rho mediate the signaling mechanisms. These results may contribute to explaining how ouabain influences cancer.

Published
2020
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46. Coordinating AgMIP data and models across global and regional scales for 1.5°C and 2.0°C assessments.

Author

Rosenzweig C, Ruane AC, Antle J, Elliott J, Ashfaq M, Chatta AA, Ewert F, Folberth C, Hathie I, Havlik P, Hoogenboom G, Lotze-Campen H, MacCarthy DS, Mason-D'Croz D, Contreras EM, Müller C, Perez-Dominguez I, Phillips M, Porter C, Raymundo RM, Sands RD, Schleussner CF, Valdivia RO, Valin H, and Wiebe K

Abstract

The Agricultural Model Intercomparison and Improvement Project (AgMIP) has developed novel methods for Coordinated Global and Regional Assessments (CGRA) of agriculture and food security in a changing world. The present study aims to perform a proof of concept of the CGRA to demonstrate advantages and challenges of the proposed framework. This effort responds to the request by the UN Framework Convention on Climate Change (UNFCCC) for the implications of limiting global temperature increases to 1.5°C and 2.0°C above pre-industrial conditions. The protocols for the 1.5°C/2.0°C assessment establish explicit and testable linkages across disciplines and scales, connecting outputs and inputs from the Shared Socio-economic Pathways (SSPs), Representative Agricultural Pathways (RAPs), Half a degree Additional warming, Prognosis and Projected Impacts (HAPPI) and Coupled Model Intercomparison Project Phase 5 (CMIP5) ensemble scenarios, global gridded crop models, global agricultural economics models, site-based crop models and within-country regional economics models. The CGRA consistently links disciplines, models and scales in order to track the complex chain of climate impacts and identify key vulnerabilities, feedbacks and uncertainties in managing future risk. CGRA proof-of-concept results show that, at the global scale, there are mixed areas of positive and negative simulated wheat and maize yield changes, with declines in some breadbasket regions, at both 1.5°C and 2.0°C. Declines are especially evident in simulations that do not take into account direct CO 2 effects on crops. These projected global yield changes mostly resulted in increases in prices and areas of wheat and maize in two global economics models. Regional simulations for 1.5°C and 2.0°C using site-based crop models had mixed results depending on the region and the crop. In conjunction with price changes from the global economics models, productivity declines in the Punjab, Pakistan, resulted in an increase in vulnerable households and the poverty rate.This article is part of the theme issue 'The Paris Agreement: understanding the physical and social challenges for a warming world of 1.5°C above pre-industrial levels'., (© 2018 The Authors.)

Published
2018
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47. Transfection in perfused microfluidic cell culture devices: A case study.

Author

Raimes W, Rubi M, Super A, Marques MPC, Veraitch F, and Szita N

Abstract

Automated microfluidic devices are a promising route towards a point-of-care autologous cell therapy. The initial steps of induced pluripotent stem cell (iPSC) derivation involve transfection and long term cell culture. Integration of these steps would help reduce the cost and footprint of micro-scale devices with applications in cell reprogramming or gene correction. Current examples of transfection integration focus on maximising efficiency rather than viable long-term culture. Here we look for whole process compatibility by integrating automated transfection with a perfused microfluidic device designed for homogeneous culture conditions. The injection process was characterised using fluorescein to establish a LabVIEW-based routine for user-defined automation. Proof-of-concept is demonstrated by chemically transfecting a GFP plasmid into mouse embryonic stem cells (mESCs). Cells transfected in the device showed an improvement in efficiency (34%, n = 3) compared with standard protocols (17.2%, n = 3). This represents a first step towards microfluidic processing systems for cell reprogramming or gene therapy.

Published
2017
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48. [High frequency of ancestral allele of the TJP1 polymorphism rs2291166 in Mexican population, conformational effect and applications in surgery and medicine].

Author

Ramirez-Garcia SA, Flores-Alvarado LJ, Topete-González LR, Charles-Niño C, Mazariegos-Rubi M, and Dávalos-Rodríguez NO

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Alleles, Amino Acid Sequence, Amino Acid Substitution, Computer Simulation, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Hydatidiform Mole genetics, Indians, North American genetics, Male, Marriage, Mexico, Middle Aged, Models, Genetic, Models, Molecular, Molecular Sequence Data, Neoplastic Syndromes, Hereditary genetics, Pancreatitis genetics, Pregnancy, Protein Conformation, Protein Stability, Spain ethnology, Young Adult, Zonula Occludens-1 Protein chemistry, Ethnicity genetics, Polymorphism, Single Nucleotide, Zonula Occludens-1 Protein genetics
Abstract

Background: TJP1 gene encodes a ZO-1 protein that is required for the recruitment of occludins and claudins in tight junction, and is involved in cell polarisation. It has different variations, the frequency of which has been studied in different populations. In Mexico there are no studies of this gene. These are required because their polymorphisms can be used in studies associated with medicine and surgery. Therefore, the aim of this study was to estimate the frequency of alleles and genotypes of rs2291166 gene polymorphism TJP1 in Mexico Mestizos population, and to estimate the conformational effect of an amino acid change., Material and Methods: A total of 473 individuals were included. The rs2291166 polymorphism was identified PASA PCR-7% PAGE, and stained with silver nitrate. The conformational effect of amino acid change was performed in silico, and was carried out with servers ProtPraram Tool and Search Database with Fasta., Results: The most frequent allele in the two populations is the ancestral allele (T). A genotype distribution similar to other populations was found. The polymorphism is in Hardy-Weinberg, p>0.05. Changing aspartate to alanine produced a conformational change., Conclusions: The study reveals a high frequency of the ancestral allele at rs2291166 polymorphism in the Mexican population., (Copyright © 2015 Academia Mexicana de Cirugía A.C. Published by Masson Doyma México S.A. All rights reserved.)

Published
2016
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49. Localized amyloidosis: a survey of 35 French cases.

Author

Paccalin M, Hachulla E, Cazalet C, Tricot L, Carreiro M, Rubi M, Grateau G, and Roblot P

Subjects
Adult, Aged, Amyloidosis metabolism, Amyloidosis therapy, Anti-Inflammatory Agents therapeutic use, Antineoplastic Agents, Alkylating therapeutic use, Case-Control Studies, Colchicine therapeutic use, Colon metabolism, Colon pathology, Data Collection, Endoscopy methods, Female, Follow-Up Studies, Gout Suppressants therapeutic use, Humans, Immunoglobulin Light Chains metabolism, Male, Melphalan therapeutic use, Middle Aged, Phototherapy methods, Prednisone therapeutic use, Prognosis, Respiratory System metabolism, Respiratory System pathology, Amyloidosis pathology
Abstract

Since the prognosis of localized amyloidosis remains unclear, we conducted a survey to define the characteristics and the course of this disease. The charts of 35 patients with either laryngeal (14 patients), tracheobronchial (10 patients), colonic (1 patient), or lower urinary tract amyloidosis (10 patients) were analyzed. The average age at diagnosis was 52.7+/-12 years (range 33-73 years). The amyloid protein type was specified to be amyloid light chain (AL) in 15 cases. All patients had undergone additional biopsies (accessory salivary glands, rectal, fat pad and bone marrow aspirates) to rule out a systemic disease. Symptomatic treatments included endoscopic excision and laser therapy. Colchicine and chemotherapy with prednisone and melphalan were prescribed with limited success. During a mean follow-up period of 6.1+/-5.3 years no patient developed a systemic form of amyloidosis. Six deaths were reported, one related to the disease because of a fatal airway hemorrhage. We suggest that immunolabeling studies should be more routinely performed. There was no risk of developing a systemic disease from local amyloid deposits in our survey. However, local evolution can be life-threatening. Such patients should be referred to specialist centers for further evaluation. Management requires close follow-up to exclude recurrence and to determine the appropriate symptomatic treatment.

Published
2005
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50. [Chronic eosinophilic pneumonia and difficult to control asthma].

Author

Rubi M, Barbe F, Togores B, Ladaria A, and Agusti AG

Subjects
Administration, Topical, Adult, Aerosols, Anti-Inflammatory Agents therapeutic use, Asthma complications, Bronchodilator Agents therapeutic use, Budesonide, Chronic Disease, Female, Glucocorticoids, Humans, Pregnenediones therapeutic use, Pulmonary Eosinophilia diagnostic imaging, Radiography, Thoracic, Asthma therapy, Pulmonary Eosinophilia complications
Abstract

We report a case of typical chronic eosinophilic pneumonia (CEP), in a female of 27 years-old suffering bronchial asthma light. Although the initial answer to the treatment with steroids was satisfactory, the patient develop difficult to control asthma (DCA). DCA is a clinical situation which requires careful investigation of several potential factors which can be solved. We suggest a protocol of treatment for patients affected with DCA.

Published
1996

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