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Abstract The Staphylococcus aureus (S. aureus) one of the important food borne pathogen from milk, which was investigated in this study. The isolates were screened for antimicrobial resistance, enterotoxin genes, biofilm formation, spa typing, coagulase gene polymorphism and accessory gene regulator types. The prevalence of S. aureus in milk samples was 34.4% (89/259). Methicillin resistant S. aureus (MRSA) was found at 27% (24/89) of the isolates, were classified as community acquired based on SCCmec typing. The 24.71% (22/89) isolates demonstrated multiple antimicrobial resistance (MAR) pattern. However, none of the isolates carried vancomycin and mupirocin resistance genes. The isolates were positive for sea and sed enterotoxin genes and exhibited high frequency of biofilm formation. The High-Resolution Melting and conventional spa typing revealed that the isolates had both animal and community-associated S. aureus clustered origins. Coagulase gene polymorphism and agr typing demonstrated variable genotypic patterns. The finding of this study establishes the prevalence of community associated, enterotoxigenic, biofilm forming and antimicrobial resistance among S. aureus from milk in Chennai city. This emphasizing a potential threat to public health which needs a continuous monitoring system and strategies to mitigate their spread across the food chain and achieve food safety.

The importance of youth entrepreneurship in the context of digital transformation makes it relevant to study its development. The article is a review of a new book on the promotion and support of young and aspiring entrepreneurs in the South African Republic. The book is characterized by novelty of views and considerable informative content. It is organized into three main parts comprising 9 chapters. Issues related to the conceptual vision of youth entrepreneurship and a large-scale initiative that was specifically designed and then piloted in the South African Republic to stimulate related activities have been addressed. The author of the peer-reviewed book emphasizes the importance of the university environment and the mechanisms formed in it, on the one hand, and entrepreneurs’ personal development, on the other. Recommendations on finding sources of funding and working with potential consumers of innovative products and services have been given. The book is written in lucid language, which is characteristic rather for educational literature, and is well illustrated. It is found to contain various references to digital transformation, and governance is considered in relation to both entrepreneurial firms created by entrepreneurs and youth entrepreneurship incentive schemes in general. The book contains interesting (including pedagogical) information that will also be useful to consider when establishing cooperation among the BRICS countries.

The changeable, unknown, complex, and multivalent world embraced by innovations makes new demands on auditors’ professional competencies, which are inseparable from the mastery of technologies. Innovative auditing technologies of regional finance and real economy auditing have been analyzed to substantiate the value of auditors’ digital maturity in the diversity of such technologies. Quantitative methods based on statistical studies confirmed the growth of audit, control, expert analytical activities, and the need to implement innovative technologies for greater coverage of the control data set. Innovative technologies used in audit practice have been presented. The definition of digital maturity in an auditor has been given, which substantiates the need for continuous training in modern technologies such as digital inspector of state and municipal financial audit, conducting and accounting of general audit results, and processing of huge arrays of reporting data, analytical dashboards, and tools for checking counterparties using the analysis of their debts and risks. Digital maturity has been proposed to be assessed by considering digital culture, professional knowledge, skills and competencies of tool ownership, and process thinking in quality data collection implementation during the udit. The planning, execution, and automation of audit control activities with innovative technologies create the basis for prompt effective management of the entire process, company resources, and regional finances. Visualization of the reporting verification results provides for their visibility for users in order to immediately make management decisions aimed at sustainable financial development.

Abstract Objective In this study we have focused on biocompatibility and osteoinductive capacity analysis of self-manufactured single-phase (HAP) and two-phase (HAP and β-ТСР) bioactive ceramics with various chemical modifications (Fig. 1). Results We demonstrate a reduction in solubility for all analyzed composite after the treatment with H2O and H2O2, accompanied by an enhancement in adsorption activity. This modification also resulted in an increase in micro- and macroporosity, along with a rise in the open porosity. Adipose-derived mesenchymal stromal cells demonstrated excellent cell adhesion and survival when cultured with these ceramics. Calcium phosphate ceramics (H-500, HT-500, and HT-1 series) stimulated alkaline phosphatase expression, promoted calcium deposition, and enhanced osteopontin expression in ADSCs, independently inducing osteogenesis without additional osteogenic stimuli. These findings underscore the promising potential of HAP-based bioceramics for bone regeneration/reconstruction. Graphical Abstract

The socio-economical importance of geological heritage (geoheritage) makes it a geological resource. New minerals are reported regularly, and their type specimens and localities are ex-situ and in-situ constituents of geoheritage, respectively. The present study focuses on the contemporary dynamics of these specific resources. For this purpose, the information about new minerals reported during the past five years is analyzed. The attention is paid to the distribution of the new mineral specimens (holotypes and cotypes) and their type localities by country; the transboundary replacement of new minerals is also considered. It is established that the new minerals-related geoheritage resources are accumulated in dozens of countries. The ex-situ geoheritage (specimens in museum collections) is represented twice narrower than the in-situ geoheritage (localities as geosites). About half of new minerals are replaced to the other countries and often to the other parts of the world. The registered patterns are explained by the peculiarities of the contemporary mineralogical research. The outcomes of the present analysis permit to make recommendations for the development of the optimal geoheritage policy.

Geomorphosite inventory remains an urgent task for many geographical domains where it can facilitate the exploration of geoheritage resources. The present study reports a new and sufficient portion of information from Mountainous Adygeya in southwestern Russia, which is a geoheritage-rich area in the western part of the Greater Caucasus Mountains. The Cossack, Monk, and Three Teeth mountains were analyzed qualitatively and semi-quantitatively. Their morphology and geological settings were described, their geoheritage properties were scored by several criteria, and their cultural meanings were considered. It was established that the total heritage values of these geomorphosites are comparable. The challenging accessibility of these landforms is offset by the availability of sites for distant observation. Each proposed geomorphosite has its own cultural meaning reflected by its name. The proposed geomorphosites are constituents of the geoheritage resources of Mountainous Adygeya, and they can be exploited via local product branding and georoute functioning.

Abstract Geological and geomorphological heritage (geoheritage) has many aspects, some of which are yet to be fully understood. Particularly, a scientific value of geo(morpho)sites is defined differently and established with not fully satisfying approaches. The attention to the El-Medallat hills, which are a group of small inselbergs in the southern Western Desert of Egypt, required the development of a new approach to focus on a scientific utility. The latter is not equated to the total value of geo(morpho)sites and their scientific value. The El-Medallat hills are put into the context of the international research in inselbergs. The relevant journal articles were collected, and the information from them was extracted to understand the relation of the El-Medallat hills to geographical and lithological foci of the international research in inselbergs. It is established that inselbergs were rarely reported from the Saharan domain of Africa, and sandstone inselbergs were studied much less intensively than granite ones. These lines of evidence imply the relatively high scientific utility of the El-Medallat geomorphosite due to its location in the Saharan domain of Africa and sandstone composition. The proposed approach is distinguished by an emphasis on research potential of geo(morpho)sites in the light of the international research experience.

Abstract While first-principles methods have been successfully applied to characterize individual properties of multi-principal element alloys (MPEA), their use in searching for optimal trade-offs between competing properties is hampered by high computational demands. In this work, we present a framework to explore Pareto-optimal compositions by integrating advanced ab initio-based techniques into a Bayesian multi-objective optimization workflow, complemented by a simple analytical model providing straightforward analysis of trends. We benchmark the framework by applying it to solid solution strengthening and ductility of refractory MPEAs, with the parameters of the strengthening and ductility models being efficiently computed using a combination of the coherent-potential approximation method, accounting for finite-temperature effects, and actively-learned moment-tensor potentials parameterized with ab initio data. Properties obtained from ab initio calculations are subsequently used to extend predictions of all relevant material properties to a large class of refractory alloys with the help of the analytical model validated by the data and relying on a few element-specific parameters and universal functions that describe bonding between elements. Our findings offer crucial insights into the traditional strength-vs-ductility dilemma of refractory MPEAs. The proposed framework is versatile and can be extended to other materials and properties of interest, enabling a predictive and tractable high-throughput screening of Pareto-optimal MPEAs over the entire composition space.

Abstract Present acceleration of interest in geoheritage makes urgent a very large inventory of geosites in all parts of the world, which task cannot be achieved by only geoconservationists. Pure geological publications seem to be promising to deal with geosites without visiting them. To realize the existence of such an opportunity, ten fresh examples of research articles reporting exceptional palaeogeographical localities from the different geographical domains and geological time slices were considered. A semi-quantitative, score-based assessment of suitability (quality) of the published information was undertaken. This procedure should be distinguished from geosite evaluation, which is not the aim of this study. It was found that the outcomes of pure geological research published in journal articles can really help to identify world-class geosites, although the information from these articles is not enough to characterize geosites (especially regarding such properties as accessibility and vulnerability). Finding additional literature and realizing conservation status are the other challenges of geosite inventories based on only journal articles. Some recommendations for writing geoheritage-unrelated articles so to satisfy the needs of geoconservation were given.

Digital management issues are extensive and are often considered from a general theoretical point of view, which makes manifestation of well-systematized practical guidelines relevant. The article presents a review of a recent and successful work on digital governance. The book consists of two introductory sections and 12 chapters combined into three parts. The issues considered in the reviewed work relate to digitalization processes and their impact on management activities, collective intelligence, and the possibilities of its application in organizational management implementation, as well as artificial intelligence, its technologies, and prospects for their use in modern management. It is strongly recommended that these technologies be implemented as part of pilot projects with testing of their effectiveness and subsequent retrofitting. It is established that the author does not focus on purely technological aspects, but, firstly, shows the continuity and interrelation of “classical” and digital management and, secondly, focuses on a manager’s personality and new challenges for them in the context of digitalization. The book is characterized by an academic, but at the same time simple and well-structured presentation of complex material. There are a lot of specifics, examples, and recommendations. Some aspects of digital management remained out of the author’s of the book field of view, but such incompleteness is inevitable. The book can be useful for specialists, teachers, and university students, as well as managers themselves.

Geological heritage sites (geosites) have various properties such as accessibility, geometry, and vulnerability, as well as age. It is reasonable to distinguish the geological ages related to the content of geosites (e.g., Early Ordovician or Valanginian) from the technical ages related to the physical appearance (forms) of geosites (e.g., Late Pleistocene, Prehistoric, or 21st century). This study examines 17 geosites known from the Western Caucasus—a geologically-rich area of the Greater Caucasus orogen. The revision and the update of the stratigraphical information allow to establish their geological ages. The technical ages are defined as old (before the 19th century), historical (19th–20th centuries), or young (the beginning of the 21st century). The results show that the analyzed geosites shed light on the lengthy time span (from the late Proterozoic to the Quaternary), and the Cisuralian–Early Cretaceous sedimentary succession of the study area is represented with significant completeness. Technically, the geosites are chiefly old, although the historical and young features are also common. The outcomes of this study do not only systematize the knowledge of the ages of the geosites from the Western Caucasus, but also have several practical implications (for instance, the conservation of the technically young geosites is the priority, and the geological ages are important to arrange the geosites logically for educational and touristic excursions).