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4. Analysis of Diagnostic Delay and its Impact on Lung Cancer Survival: Results From the Spanish Thoracic Tumor Registry

Author

Candal-Pedreira, Cristina, Ruano-Ravina, Alberto, Calvo de Juan, Virginia, Cobo, Manuel, Cantero, Alexandra, Rodríguez-Abreu, Delvys, Estival, Anna, Carcereny, Enric, Hernandez, Ainhoa, López Castro, Rafael, Medina, Andrea, García Campelo, Rosario, Fernández Bruno, Manuel, Barnabé, Reyes, Bosch-Barrera, Joaquim, Massutí, Bartomeu, Dómine, Manuel, Camps, Carlos, Ortega, Ana Laura, and Provencio, Mariano

Published
2024
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9. Lung Function and Symptoms of Exposure to the Volcanic Eruption in the Canary Islands: First Follow-Up of the ASHES Study

Author

Candal-Pedreira, Cristina, Díaz-Pérez, David, Velasco, Valle, Casanova, Ciro, Acosta, Orlando, Peces-Barba, Germán, Barreiro, Esther, Cañas, Ana, Castaño, Argelia, Cruz Carmona, María Jesús, Diego, Carmen, Garcia-Aymerich, Judith, Martínez, Cristina, Molina-Molina, María, Muñoz, Xavier, Sánchez-Íñigo, Francisco Javier, and Ruano-Ravina, Alberto

Published
2024
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14. Comparison of Clinical and Genetic Characteristics Between Younger and Older Lung Cancer Patients

Author

Candal-Pedreira, Cristina, Ruano-Ravina, Alberto, Calvo de Juan, Virginia, Cobo, Manuel, Trigo, José Manuel, Rodríguez-Abreu, Delvys, Estival, Anna, Carcereny, Enric, Cucurull, Marc, López Castro, Rafael, Medina, Andrea, García Campelo, Rosario, Cordeiro González, Patricia, Sánchez-Gastaldo, Amparo, Bosch-Barrera, Joaquim, Massutí, Bartomeu, Dómine, Manuel, Camps, Carlos, Ortega, Ana Laura, Sánchez-Hernández, Alfredo, Guirado Risueño, María, del Barco Morillo, Edel, Garrido Fernández, Alberto, and Provencio, Mariano

Published
2024
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19. Tobacco Patterns and Risk of Chronic Obstructive Pulmonary Disease: Results From a Cross-Sectional Study

Author

Rey-Brandariz, Julia, Pérez-Ríos, Mónica, Ahluwalia, Jasjit S., Beheshtian, Kiana, Fernández-Villar, Alberto, Represas-Represas, Cristina, Piñeiro, María, Alfageme, Inmaculada, Ancochea, Julio, Soriano, Joan B., Casanova, Ciro, Cosío, Borja G., García-Río, Francisco, Miravitlles, Marc, de Lucas, Pilar, Rodríguez González-Moro, José Miguel, Soler-Cataluña, Juan José, and Ruano-Ravina, Alberto

Published
2023
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21. Association between duration of smoking abstinence before non-small-cell lung cancer diagnosis and survival: a retrospective, pooled analysis of cohort studies

Author

Fares, Aline F, Li, Yao, Jiang, Mei, Brown, M Catherine, Lam, Andrew C L, Aggarwal, Reenika, Schmid, Sabine, Leighl, Natasha B, Shepherd, Frances A, Wang, Zhichao, Diao, Nancy, Wenzlaff, Angela S, Xie, Juntao, Kohno, Takashi, Caporaso, Neil E, Harris, Curtis, Ma, Hongxia, Barnett, Matthew J, Leal, Leticia Ferro, Fernandez-Tardon, G, Pérez-Ríos, Mónica, Davies, Michael P A, Taylor, Fiona, Schöttker, Ben, Brennan, Paul, Zaridze, David, Holcatova, Ivana, Lissowska, Jolanta, Świątkowska, Beata, Mates, Dana, Savic, Milan, Brenner, Hermann, Andrew, Angeline, Cox, Angela, Field, John K, Ruano-Ravina, Alberto, Shete, Sanjay S, Tardon, Adonina, Wang, Ying, Le Marchand, Loic, Reis, Rui Manuel, Schabath, Matthew B, Chen, Chu, Shen, Hongbing, Ryan, Brid M, Landi, Maria Teresa, Shiraishi, Kouya, Zhang, Jie, Schwartz, Ann G, Tsao, Ming S, Christiani, David C, Yang, Ping, Hung, Rayjean J, Xu, Wei, and Liu, Geoffrey

Published
2023
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31. Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 5p15.33 TERT-CLPTM1Ll Region

Author

Hung, Rayjean J, Spitz, Margaret R, Houlston, Richard S, Schwartz, Ann G, Field, John K, Ying, Jun, Li, Yafang, Han, Younghun, Ji, Xuemei, Chen, Wei, Wu, Xifeng, Gorlov, Ivan P, Na, Jie, de Andrade, Mariza, Liu, Geoffrey, Brhane, Yonathan, Diao, Nancy, Wenzlaff, Angela, Davies, Michael PA, Liloglou, Triantafillos, Timofeeva, Maria, Muley, Thomas, Rennert, Hedy, Saliba, Walid, Ryan, Bríd M, Bowman, Elise, Barros-Dios, Juan-Miguel, Pérez-Ríos, Mónica, Morgenstern, Hal, Zienolddiny, Shanbeh, Skaug, Vidar, Ugolini, Donatella, Bonassi, Stefano, van der Heijden, Erik HFM, Tardon, Adonina, Bojesen, Stig E, Landi, Maria Teresa, Johansson, Mattias, Bickeböller, Heike, Arnold, Susanne, Le Marchand, Loic, Melander, Olle, Andrew, Angeline, Grankvist, Kjell, Caporaso, Neil, Teare, M Dawn, Schabath, Matthew B, Aldrich, Melinda C, Kiemeney, Lambertus A, Wichmann, H-Erich, Lazarus, Philip, Mayordomo, Jose, Neri, Monica, Haugen, Aage, Zhang, Zuo-Feng, Ruano-Raviña, Alberto, Brenner, Hermann, Harris, Curtis C, Orlow, Irene, Rennert, Gadi, Risch, Angela, Brennan, Paul, Christiani, David C, Amos, Christopher I, Yang, Ping, and Gorlova, Olga Y

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Human Genome, Lung Cancer, Tobacco, Prevention, Cancer, Genetics, Clinical Research, Tobacco Smoke and Health, Lung, 2.1 Biological and endogenous factors, Aetiology, Good Health and Well Being, Case-Control Studies, Chromosomes, Human, Pair 5, Europe, Female, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Genotyping Techniques, Humans, Lung Neoplasms, Membrane Proteins, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors, Telomerase, Lung cancer, Never smokers, Genome-wide association study, Genetic susceptibility, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract

IntroductionInherited susceptibility to lung cancer risk in never-smokers is poorly understood. The major reason for this gap in knowledge is that this disease is relatively uncommon (except in Asians), making it difficult to assemble an adequate study sample. In this study we conducted a genome-wide association study on the largest, to date, set of European-descent never-smokers with lung cancer.MethodsWe conducted a two-phase (discovery and replication) genome-wide association study in never-smokers of European descent. We further augmented the sample by performing a meta-analysis with never-smokers from the recent OncoArray study, which resulted in a total of 3636 cases and 6295 controls. We also compare our findings with those in smokers with lung cancer.ResultsWe detected three genome-wide statistically significant single nucleotide polymorphisms rs31490 (odds ratio [OR]: 0.769, 95% confidence interval [CI]: 0.722-0.820; p value 5.31 × 10-16), rs380286 (OR: 0.770, 95% CI: 0.723-0.820; p value 4.32 × 10-16), and rs4975616 (OR: 0.778, 95% CI: 0.730-0.829; p value 1.04 × 10-14). All three mapped to Chromosome 5 CLPTM1L-TERT region, previously shown to be associated with lung cancer risk in smokers and in never-smoker Asian women, and risk of other cancers including breast, ovarian, colorectal, and prostate.ConclusionsWe found that genetic susceptibility to lung cancer in never-smokers is associated to genetic variants with pan-cancer risk effects. The comparison with smokers shows that top variants previously shown to be associated with lung cancer risk only confer risk in the presence of tobacco exposure, underscoring the importance of gene-environment interactions in the etiology of this disease.

Published
2019

36. Residential Radon and Small Cell Lung Cancer. Final Results of the Small Cell Study

Author

Rodríguez-Martínez, Ángeles, Ruano-Ravina, Alberto, Torres-Durán, María, Provencio, Mariano, Parente-Lamelas, Isaura, Vidal-García, Iria, Martínez, Cristina, Hernández-Hernández, Jesús, Abdulkader-Nallib, Ihab, Castro-Añón, Olalla, Varela-Lema, Leonor, Piñeiro-Lamas, María, Fidalgo, Paula Sales, Fernández-Villar, Alberto, Barros-Dios, Juan, and Pérez-Ríos, Mónica

Published
2022
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39. Discrepancies in the results reported for multiple sclerosis clinical trials: A comparison between ClinicalTrials.gov and peer-reviewed journals.

Author

Rivero-de-Aguilar, Alejandro, Pérez-Ríos, Mónica, Mascareñas-García, Marta, Ruano-Raviña, Alberto, Ross, Joseph S, Casal-Acción, Beatriz, and Varela-Lema, Leonor

Subjects
MULTIPLE sclerosis, CAUSES of death, CLINICAL trials, TIME management
Abstract

Objective: We aimed to compare the results of phase III and IV clinical trials examining drugs to treat multiple sclerosis (MS) registered at ClinicalTrials.gov to those published in peer-reviewed journals. Methods: After identifying trials registered at ClinicalTrials.gov, consecutive searches were conducted in PubMed, EMBASE and Google Scholar for matching publications. Information regarding participants and efficacy and safety results was extracted and compared. The degree of consistency was classified as 'concordant', 'discrepant' or 'not comparable'. The Kaplan–Meier method was used to model time to reporting. Results: In total, 65 trials were appraised. The median time from completion to reporting was shorter for ClinicalTrials.gov (16.4 vs 27.3 months; p = 0.010). Information availability was generally higher in journals except for serious adverse events (SAEs) (86.2% vs 100.0%, p = 0.029) and their description (78.2% vs 100.0%, p < 0.001). However, 45 trials had at least one reporting discrepancy (69.2%). Three studies omitted one or more primary outcomes in the matching journal publication. Regarding safety results, the lowest consistencies were found for causes of death (60.0%) and description of SAEs (27.9%). Conclusion: Consulting both ClinicalTrials.gov and journals increases the accessibility to MS clinical trial results. Some data were frequently missing or disagreed between sources, raising concerns about transparency and generalizability of results. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Indoor Radon Exposure and COPD, Synergic Association? A Multicentric, Hospital-Based Case–Control Study in a Radon-Prone Area

Author

Ruano-Ravina, Alberto, Cameselle-Lago, Candela, Torres-Durán, María, Pando-Sandoval, Ana, Dacal-Quintas, Raquel, Valdés-Cuadrado, Luis, Hernández-Hernández, Jesús, Consuegra-Vanegas, Angélica, Tenes-Mayén, José Andrés, Varela-Lema, Leonor, Fernández-Villar, Alberto, Barros-Dios, Juan Miguel, and Pérez-Ríos, Mónica

Published
2021
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48. Effectiveness of smoking cessation interventions among pregnant women: An updated systematic review and meta-analysis

Author

Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina, Vila Fariñas, Andrea, Pérez Ríos, Mónica, Montes Martínez, Agustín, Ruano Raviña, Alberto, Forray, Ariadna, Rey Brandariz, Julia, Candal Pedreira, Cristina, Fernández, Esteve, Casal Acción, B., Varela Lema, María Leonor, Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina, Vila Fariñas, Andrea, Pérez Ríos, Mónica, Montes Martínez, Agustín, Ruano Raviña, Alberto, Forray, Ariadna, Rey Brandariz, Julia, Candal Pedreira, Cristina, Fernández, Esteve, Casal Acción, B., and Varela Lema, María Leonor

Abstract

Objective: To carry out a systematic review of systematic reviews with an update of the existing evidence relating to a broad range of smoking cessation interventions, including psycho-social, digital and pharmacologic interventions, for pregnant women. Data-sources: Search was conducted in March 2022 in PubMed, EMBASE, and Cochrane in two stages: 1) a search of systematic reviews and meta-analyses, published from January 2012 through January 2022; 2) an update of those that fulfilled eligibility criteria reproducing the primary search strategy. Study eligibility criteria: We selected randomized clinical trials (RCTs) that evaluated the effectiveness of pharmacological, digital, and psychosocial interventions in aged 18 years and over who were daily smokers, and compared these with routine care, less intense interventions or placebo. Study appraisal and synthesis methods: Data from eligible studies were manually extracted by two authors and reviewed by a third. The quality of the reviews was evaluated using the AMSTAR scale, and risk of bias was measured with the Rob-2 tool and GRADE level of evidence. Results: The meta-analysis included 63 RCTs (n = 19849 women). The interventions found to be effective were: financial incentives (RR:1.77; 95%CI:1.21–2.58), counseling (RR:1.27; 95%CI:1.13–1.43) and long-term nicotine replacement therapy (NRT) (RR:1.53; 95%CI:1.16–2.01). Short-term NRT, bupropion, digital interventions, feedback, social support, and exercise showed no effectiveness. The GRADE level of evidence was moderate-tohigh for all interventions, with the exception of long-term NRT. Conclusions: Non-pharmacological interventions for smoking cessation are the most effective for pregnant women. The moderator analysis suggests that pregnant women of low socioeconomic status might benefit less from smoking cessation interventions than women of a high socioeconomic status. These women are usually heavier smokers that live in pro-smoking environments and could requir

Published
2024

49. Genome Wide Association Studies in Small-Cell Lung Cancer. A Systematic Review

Author

Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina, Enjo Barreiro, José Ramón, Ruano Raviña, Alberto, Pérez Ríos, Mónica, Kelsey, Karl, Barros Dios, Juan, Varela Lema, María Leonor, Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina, Enjo Barreiro, José Ramón, Ruano Raviña, Alberto, Pérez Ríos, Mónica, Kelsey, Karl, Barros Dios, Juan, and Varela Lema, María Leonor

Abstract

Small cell lung cancer (SCLC) is one of the deadliest forms of lung cancer, but few information exists regarding the role of genetics, particularly on Genome Wide Association Studies (GWAS). The aim of the study is to explore the evidence available obtained through GWAS studies for SCLC using a systematic review. We performed a literature search in the main databases until July 31st, 2023. We included all human based studies on GWAS for lung cancer which presented results for SCLC. Only studies with participants diagnosed of SCLC with anatomopathological confirmation were included. Fourteen studies were identified; 8 studies showed a relationship between ASCL1 overexpression and SCLC, which may regulate CHRNA5/A3/B4 cluster, producing a consequent nAChR overexpression. Nine papers, including 8 of the previous, found a positive association between SNPs located in chromosome 15 and SCLC. The most important cluster of genes found is CHRNA5/A3/B4 but the mechanism for the role of these genes is unclear. Kyoto Encyclopaedia of Genes and Genome (KEGG) shows that these receptors were found to be overexpressed where nicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N’-Nitrosonornicotine (NNN) acts, involving different routes in SCLC carcinogenesis

Published
2024

50. Carga de mortalidad atribuida al consumo de tabaco en España y sus comunidades autónomas

Author

Pérez Ríos, Mónica, Ruano Raviña, Alberto, Área Ciencias da Saúde Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS), Universidade de Santiago de Compostela. Programa de Doutoramento en Epidemioloxía e Saúde Pública, Rey Brandariz, Julia, Pérez Ríos, Mónica, Ruano Raviña, Alberto, Área Ciencias da Saúde Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS), Universidade de Santiago de Compostela. Programa de Doutoramento en Epidemioloxía e Saúde Pública, and Rey Brandariz, Julia

Abstract

El consumo de tabaco es uno de los factores de riesgo que mayor mortalidad produce a nivel mundial y es el principal factor de riesgo del cáncer de pulmón. El radón es el segundo factor de riesgo en el desarrollo de cáncer de pulmón en fumadores y el primero en nunca fumadores. Los resultados de esta tesis permiten caracterizar la epidemia tabáquica en España al estudiar la evolución de la prevalencia y la mortalidad atribuida a su consumo. Además, se estima por primera vez la mortalidad atribuida al consumo de tabaco y a la exposición a radón residencial en las 17 comunidades autónomas de España y al consumo de tabaco en las siete regiones de Portugal. Por último, se presenta una guía metodológica que permite aumentar la calidad de las estimaciones de mortalidad atribuida a diferentes factores de riesgo.

Published
2024

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