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A long-standing and intriguing question is: does the holographic principle apply to cosmologies like de Sitter spacetime? In this work, we consider a half dS spacetime wherein a timelike boundary encloses the bulk spacetime, presenting a version of de Sitter holography. By analyzing the holographic entanglement entropy in this space and comparing it with that in AdS/CFT, we argue that gravity on a half dSd+1 is dual to a highly non-local field theory residing on dSd boundary. This non-locality induces a breach in the subadditivity of holographic entanglement entropy. Remarkably, this observation can be linked to another argument that time slices in global de Sitter space overestimate the degrees of freedom by redundantly counting the same Hilbert space multiple times. [ABSTRACT FROM AUTHOR]

In this paper, we investigate gluing together two Anti-de Sitter (AdS) geometries along a timelike brane, which corresponds to coupling two brane field theories (BFTs) through gravitational interactions in the dual holographic perspective. By exploring the general conditions for this gluing process, we show that the energy stress tensors of the BFTs backreact on the dynamical metric in a manner reminiscent of the TTbar deformation. In particular, we present explicit solutions for the three-dimensional case with chiral excitations and further construct perturbative solutions with non-chiral excitations. [ABSTRACT FROM AUTHOR]

We investigate how the complexity=anything observables proposed by [1, 2] can be used to investigate the interior geometry of AdS black holes. In particular, we illustrate how the flexibility of the complexity=anything approach allows us to systematically probe the geometric properties of black hole singularities. We contrast our results for the AdS Schwarzschild and AdS Reissner-Nordström geometries, i.e., for uncharged and charged black holes, respectively. In the latter case, the holographic complexity observables can only probe the interior up to the inner horizon. [ABSTRACT FROM AUTHOR]

We expand on our results in [1] to present a broad new class of gravitational observables in asymptotically Anti-de Sitter space living on general codimension-zero regions of the bulk spacetime. By taking distinct limits, these observables can reduce to well-studied holographic complexity proposals, e.g., the volume of the maximal slice and the action or spacetime volume of the Wheeler-DeWitt patch. As with the codimension-one family found in [1], these new observables display two key universal features for the thermofield double state: they grow linearly in time at late times and reproduce the switchback effect. Hence we argue that any member of this new class of observables is an equally viable candidate as a gravitational dual of complexity. Moreover, using the Peierls construction, we show that variations of the codimension-zero and codimension-one observables are encoded in the gravitational symplectic form on the semi-classical phase-space, which can then be mapped to the CFT. [ABSTRACT FROM AUTHOR]

We study the CV, CA, and CV2.0 approaches to holographic complexity in (d + 1)-dimensional de Sitter spacetime. We find that holographic complexity and corresponding growth rate presents universal behaviour for all three approaches. In particular, the holographic complexity exhibits 'hyperfast' growth [1] and appears to diverge with a universal power law at a (finite) critical time. We introduce a cutoff surface to regulate this divergence, and the subsequent growth of the holographic complexity is linear in time. [ABSTRACT FROM AUTHOR]

We examine holographic complexity in the doubly holographic model introduced in [1, 2] to study quantum extremal islands. We focus on the holographic complexity=volume (CV) proposal for boundary subregions in the island phase. Exploiting the Fefferman-Graham expansion of the metric and other geometric quantities near the brane, we derive the leading contributions to the complexity and interpret these in terms of the generalized volume of the island derived from the induced higher-curvature gravity action on the brane. Motivated by these results, we propose a generalization of the CV proposal for higher curvature theories of gravity. Further, we provide two consistency checks of our proposal by studying Gauss-Bonnet gravity and f(ℛ) gravity in the bulk. [ABSTRACT FROM AUTHOR]

Gastric cancer is a deadly disease and remains the third leading cause of cancer-related death worldwide. The 5-year overall survival rate of patients with early-stage localized gastric cancer is more than 60%, whereas that of patients with distant metastasis is less than 5%. Surgical resection is the best option for early-stage gastric cancer, while chemotherapy is mainly used in the middle and advanced stages of this disease, despite the frequently reported treatment failure due to chemotherapy resistance. Therefore, there is an unmet medical need for identifying new biomarkers for the early diagnosis and proper management of patients, to achieve the best response to treatment. Long non-coding RNAs (lncRNAs) in body fluids have attracted widespread attention as biomarkers for early screening, diagnosis, treatment, prognosis, and responses to drugs due to the high specificity and sensitivity. In the present review, we focus on the clinical potential of lncRNAs as biomarkers in liquid biopsies in the diagnosis and prognosis of gastric cancer. We also comprehensively discuss the roles of lncRNAs and their molecular mechanisms in gastric cancer chemoresistance as well as their potential as therapeutic targets for gastric cancer precision medicine. [ABSTRACT FROM AUTHOR]

We study the doubly holographic model of [1] in the situation where a black hole in two-dimensional JT gravity theory is coupled to an auxiliary bath system at arbitrary finite temperature. Depending on the initial temperature of the black hole relative to the bath temperature, the black hole can lose mass by emitting Hawking radiation, stay in equilibrium with the bath or gain mass by absorbing thermal radiation from the bath. In all of these scenarios, a unitary Page curve is obtained by applying the usual prescription for holographic entanglement entropy and identifying the quantum extremal surface for the generalized entropy, using both analytical and numeric calculations. As the application of the entanglement wedge reconstruction, we further investigate the reconstruction of the black hole interior from a subsystem containing the Hawking radiation. We examine the roles of the Hawking radiation and also the purification of the thermal bath in this reconstruction. [ABSTRACT FROM AUTHOR]

We investigate the first law of complexity proposed in Bernamonti et al (2019 Phys. Rev. Lett. 123 081601), i.e., the variation of complexity when the target state is perturbed, in more detail. Based on Nielsen's geometric approach to quantum circuit complexity, we find the variation only depends on the end of the optimal circuit. We apply the first law to gain new insights into the quantum circuits and complexity models underlying holographic complexity. In particular, we examine the variation of the holographic complexity for both the complexity = action and complexity = volume conjectures in perturbing the AdS vacuum with coherent state excitations of a free scalar field. We also examine the variations of circuit complexity produced by the same excitations for the free scalar field theory in a fixed AdS background. In this case, our work extends the existing treatment of Gaussian coherent states to properly include the time dependence of the complexity variation. We comment on the similarities and differences of the holographic and QFT results. [ABSTRACT FROM AUTHOR]

We study the complexity of Gaussian mixed states in a free scalar field theory using the ‘purification complexity’. The latter is defined as the lowest value of the circuit complexity, optimized over all possible purifications of a given mixed state. We argue that the optimal purifications only contain the essential number of ancillary degrees of freedom necessary in order to purify the mixed state. We also introduce the concept of ‘mode-by- mode purifications’ where each mode in the mixed state is purified separately and examine the extent to which such purifications are optimal. We explore the purification complexity for thermal states of a free scalar QFT in any number of dimensions, and for subregions of the vacuum state in two dimensions. We compare our results to those found using the various holographic proposals for the complexity of subregions. We find a number of qualitative similarities between the two in terms of the structure of divergences and the presence of a volume law. We also examine the ‘mutual complexity’ in the various cases studied in this paper. [ABSTRACT FROM AUTHOR]

Recently, new holographic models of black hole evaporation have given fresh insights into the information paradox [1–3]. In these models, the black hole evaporates into an auxiliary bath space after a quantum quench, wherein the holographic theory and the bath are joined. One particularly exciting development is the appearance of ‘ER=EPR’-like wormholes in the (doubly) holographic model of [3]. At late times, the entanglement wedge of the bath includes the interior of the black hole. In this paper, we employ both numerical and analytic methods to study how information about the black hole interior is encoded in the Hawking radiation. In particular, we systematically excise intervals from the bath from the system and study the corresponding Page transition. Repeating this process ad infinitum, we end up with a fractal structure on which the black hole interior is encoded, implementing the überholography protocol of [4]. [ABSTRACT FROM AUTHOR]

We examine the circuit complexity of coherent states in a free scalar field theory, applying Nielsen’s geometric approach as in [1]. The complexity of the coherent states have the same UV divergences as the vacuum state complexity and so we consider the finite increase of the complexity of these states over the vacuum state. One observation is that generally, the optimal circuits introduce entanglement between the normal modes at intermediate stages even though our reference state and target states are not entangled in this basis. We also compare our results from Nielsen’s approach with those found using the Fubini-Study method of [2]. For general coherent states, we find that the complexities, as well as the optimal circuits, derived from these two approaches, are different. [ABSTRACT FROM AUTHOR]