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Your search keyword '"Ruan, Hongjie"' showing total 40 results
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40 results on '"Ruan, Hongjie"'

1. Efficacy and safety of oral ibrexafungerp in Chinese patients with vulvovaginal candidiasis: a phase III, randomized, double-blind study

Author

Wang, Xiaoqian, Wang, Wenying, Li, Jingjing, An, Ruifang, Chen, Lihong, Lin, Jiajing, Xu, Dabao, Qiu, Jin, Song, Weihua, Patiman, Mijiti, Ruan, Hongjie, Wang, Gang, Xue, Fengxia, Wang, Xu, Luo, Xiaowan, Ruan, Qi, Shi, Ling, Zhang, Chun, Hu, Lina, Wang, Shijin, Shi, Hong, Wang, Xiaoli, Zhang, Songling, Li, Yingxiong, Lu, Jing, Wang, Baojin, Xu, Hongyan, Ye, Hong, Zhang, Bei, Zhang, Chunlian, Qian, Sumin, Wu, Qiong, Jia, Wen, Li, Chuan, and Liao, Qinping

Published
2024
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3. Electrospun Antimicrobial Polymeric Nanofibers in Wound Dressings

Author

Shi, Yunfan, Zhang, Chenzi, Jiang, Feng, Zhou, Liuzhu, Cai, Ling, Ruan, Hongjie, Chen, Jin, Abe, Akihiro, Editorial Board Member, Albertsson, Ann-Christine, Editorial Board Member, Coates, Geoffrey W., Editorial Board Member, Genzer, Jan, Editorial Board Member, Kobayashi, Shiro, Editorial Board Member, Lee, Kwang-Sup, Editorial Board Member, Leibler, Ludwik, Editorial Board Member, Long, Timothy E., Editorial Board Member, Möller, Martin, Editorial Board Member, Okay, Oguz, Editorial Board Member, Percec, Virgil, Editorial Board Member, Tang, Ben Zhong, Editorial Board Member, Terentjev, Eugene M., Editorial Board Member, Theato, Patrick, Editorial Board Member, Voit, Brigitte, Editorial Board Member, Wiesner, Ulrich, Editorial Board Member, Zhang, Xi, Editorial Board Member, and Jayakumar, R., editor

Published
2023
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15. One-pot synthesis of α-Linolenic acid nanoemulsion-templated drug-loaded silica mesocomposites as efficient bactericide against drug-resistant Mycobacterium tuberculosis

Author

Zhu, Ping, primary, Cai, Ling, additional, Liu, Qiao, additional, Feng, Shanwu, additional, Ruan, Hongjie, additional, Zhang, Li, additional, Zhou, Liuzhu, additional, Jiang, Huijun, additional, Wang, Hongsheng, additional, Wang, Jianming, additional, and Chen, Jin, additional

Published
2022
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17. Pulmonary Benefits of Intervention with Air Cleaner among Schoolchildren in Beijing: A Randomized Double-Blind Crossover Study

Author

Yang, Xiaoyan, primary, Wang, Qin, additional, Han, Feng, additional, Dong, Bin, additional, Wen, Bo, additional, Li, Li, additional, Ruan, Hongjie, additional, Zhang, Shaoping, additional, Kong, Jian, additional, Zhi, Hong, additional, Wang, Chong, additional, Wang, Jun, additional, Zhang, Ming, additional, and Xu, Dongqun, additional

Published
2021
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19. Identification of microRNA expression profiles of CD44+ ovarian cancer stem cells.

Author

Wang, Luyao, Zhi, Xiaogai, Lu, Yingying, Cong, Yu, Fu, Ziyi, Cao, Jian, Xu, Sujuan, Lv, Juan, and Ruan, Hongjie

Abstract

Purpose: The aim of our study was to investigate microRNA (miRNA) expression profiles in CD44+ ovarian cancer stem cells (ovarian CSCs). Methods: In this study, we enriched CD44+ ovarian CSCs using magnetic activated cell sorting (MACS). A combination of real-time quantitative PCR (qRT-PCR), western blot and sphere formation assays was used to demonstrate stem cell-like properties. RNA sequencing was used to detect the miRNA expression profiles in CD44+ ovarian CSCs. Transient transfection, qRT-PCR, western blot and sphere formation assays were further used to test the function of miR-181a-2-3p. Results: We found that CD44+ ovarian CSCs showed enhanced sphere formation and expression of stemness-associated genes (NANOG, OCT4, SOX2) compared to ovarian cancer cells. The RNA sequencing results showed that the miRNA expression profiles of CD44+ ovarian CSCs were different from those of ovarian cancer cells. GO and KEGG pathway analyses indicated that these miRNAs regulate stem cell-like properties in CD44+ ovarian CSCs. In addition, miR-181a-2-3p negatively regulates the stem cell-like properties of CD44+ ovarian CSCs by targeting EGR1. Conclusion: Our data suggest that miRNAs play important roles in regulating the stem cell-like properties of CD44+ ovarian CSCs. [ABSTRACT FROM AUTHOR]

Published
2022
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24. Pulmonary Benefits of Intervention with HEPA Air Purifier in Schoolchildren: A Double-Blind Crossover Study

Author

Yang, Xiaoyan, primary, Wang, Qin, additional, Han, Feng, additional, Dong, Bin, additional, Wen, Bo, additional, Li, Li, additional, Ruan, Hongjie, additional, Zhang, Shaoping, additional, Kong, Jian, additional, Zhi, Hong, additional, Wang, Chong, additional, Wang, Jun, additional, Zhang, Ming, additional, and Xu, Dongqun, additional

Published
2021
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36. Benzotriazole Enhances Cell Invasive Potency in Endometrial Carcinoma Through CTBP1-Mediated Epithelial-Mesenchymal Transition

Author

Wang, Yiquan, primary, Dai, Chencheng, additional, Zhou, Cheng, additional, Li, Wenqu, additional, Qian, Yujia, additional, Wen, Juan, additional, Wang, Yang, additional, Han, Bing, additional, Ma, Jingjing, additional, Xu, Juan, additional, Fu, Ziyi, additional, Ruan, Hongjie, additional, Tong, Hua, additional, and Jia, Xuemei, additional

Published
2017
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37. Distinct expression profile of lncRNA in endometrial carcinoma

Author

Xu, Juan, primary, Qian, Yujia, additional, Ye, Min, additional, Fu, Ziyi, additional, Jia, Xuemei, additional, Li, Wenqu, additional, Xu, Pengfei, additional, Lv, Mingming, additional, Huang, Lei, additional, Wang, Luyu, additional, Ruan, Hongjie, additional, and Lv, Juan, additional

Published
2016
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38. APL-1702 long-term efficacy and safety for cervical histologic, high-grade squamous intraepithelial lesions: Results from a randomized, phase III, global study.

Author

Wang, Yue, Chen, Fei, Lang, Jinghe, Hillemanns, Peter, Ruan, Hongjie, Chen, Xinyan, Novak, Zoltan, Zhang, Youzhong, You, Zhixue, Wei, Bing, Lv, Weiguo, Yu, Jing, Liu, Mingxing, Woelber, Linn, Vladimir, Dvorak, Tang, Junying, Song, Weihua, Li, Rui, He, Eileen, and Chen, Echo

Subjects
*SAFETY
Published
2024
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39. Oteseconazole versus fluconazole for the treatment of severe vulvovaginal candidiasis: a multicenter, randomized, double-blinded, phase 3 trial.

Author

Wang X, Chen L, Ruan H, Xiong Z, Wang W, Qiu J, Song W, Zhang C, Xue F, Qin T, Zhang B, An R, Luo X, Wang W, Zhang S, Cai Y, Kang J, Deng H, Fan S, Cui M, Wang S, Luo X, Su Z, Shu J, Wang Q, Wang F, Bai J, and Liao Q

Subjects
Female, Humans, Antifungal Agents adverse effects, Candida, Administration, Oral, Candida albicans, Fluconazole pharmacology, Candidiasis, Vulvovaginal drug therapy, Candidiasis, Vulvovaginal microbiology
Abstract

Vulvovaginal candidiasis (VVC) is a common condition among women. Fluconazole remains the dominant treatment option for VVC. Oteseconazole is a highly selective inhibitor of fungal CYP51. This randomized, double-blinded, phase 3 trial was conducted to evaluate the efficacy and safety of oteseconazole compared with fluconazole in treating severe VVC. Female subjects presenting with vulvovaginal signs and symptoms score of ≥7 and positive Candida infection determined by potassium hydroxide test or Gram staining were randomly assigned to receive oteseconazole (600 mg on D1 and 450 mg on D2) or fluconazole (150 mg on D1 and D4) in a 1:1 ratio. The primary endpoint was the proportion of subjects achieving therapeutic cure [defined as achieving both clinical cure (absence of signs and symptoms of VVC) and mycological cure (negative culture of Candida species)] at D28. A total of 322 subjects were randomized and 321 subjects were treated. At D28, a statistically significantly higher proportion of subjects achieved therapeutic cure in the oteseconazole group than in the fluconazole group (66.88% vs 45.91%; P = 0.0002). Oteseconazole treatment resulted in an increased proportion of subjects achieving mycological cure (82.50% vs 59.12%; P < 0.0001) and clinical cure (71.25% vs 55.97%; P = 0.0046) compared with fluconazole. The incidence of treatment-emergent adverse events was similar between the two groups. No subjects discontinued study treatment or withdrew study due to adverse events. Oteseconazole showed statistically significant and clinically meaningful superiority over fluconazole for the treatment of severe VVC and was generally tolerated., Competing Interests: Quanren Wang and Fang Wang are employees of Jiangsu Hengrui Pharmaceuticals Co., Ltd. No potential conflicts of interest are reported by other authors.

Published
2024
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40. Lobaplatin Induces Pyroptosis in Cervical Cancer Cells via the Caspase-3/GSDME Pathway.

Author

Chen J, Ge L, Shi X, Liu J, Ruan H, Heng D, and Ye C

Subjects
Cell Line, Tumor, Cyclobutanes pharmacology, Female, Humans, Receptors, Estrogen metabolism, Caspase 3 metabolism, Organoplatinum Compounds pharmacology, Pore Forming Cytotoxic Proteins metabolism, Pyroptosis drug effects, Uterine Cervical Neoplasms drug therapy
Abstract

Background: Increasing evidence shows that GSDME is involved in tumor chemotherapy. Lobaplatin is an important chemotherapy drug for the treatment of cervical cancer. However, the exact mechanism of lobaplatin in the treatment of cervical cancer remains unclear., Objective: In this study, whether GSDME is a new mechanism of lobaplatin in the treatment of cervical cancer has been explored., Methods: Cell pyroptosis was measured by Cell Counting Kit-8 and flow cytometry analyses. Western blot analysis was used to check proteins expression., Results: The cell viability was significantly decreased by lobaplatin treatment. Compared with the control group, the percentage of pyroptosis (PI and Annexin-V double-positive cells) increased after lobaplatin treatment. In addition, lobaplatin induced caspase-3 activation and GSDME cleavage. z-DEVD, a specific inhibitor of caspase-3, reduced lobaplatin-mediated GSDME cleavage and concurrently inhibited pyroptosis. More importantly, GSDME deficiency obviously reduced lobaplatin-induced pyroptosis., Conclusion: These data demonstrate that caspase-3/GSDME axis contributed to the lobaplatin-mediated pyroptosis in cervical cancer cells. This finding indicates that GSDME-mediated pyroptosis is a new mechanism for lobaplatin to kill tumor cells and suggests that the caspase-3/GSDME pathway offers new insights into cancer chemotherapy., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Published
2022
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