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23 results on '"Rua, Réjane"'

8. Potent neutralizing antibodies in humans infected with zoonotic simian foamy viruses target conserved epitopes located in the dimorphic domain of the surface envelope protein

Author

Lambert, Caroline, primary, Couteaudier, Mathilde, additional, Gouzil, Julie, additional, Richard, Léa, additional, Montange, Thomas, additional, Betsem, Edouard, additional, Rua, Réjane, additional, Tobaly-Tapiero, Joelle, additional, Lindemann, Dirk, additional, Njouom, Richard, additional, Mouinga-Ondémé, Augustin, additional, Gessain, Antoine, additional, and Buseyne, Florence, additional

Published
2018
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10. HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4 + T Cells

Author

Vermeire, Jolien, primary, Roesch, Ferdinand, additional, Sauter, Daniel, additional, Rua, Réjane, additional, Hotter, Dominik, additional, Van Nuffel, Anouk, additional, Vanderstraeten, Hanne, additional, Naessens, Evelien, additional, Iannucci, Veronica, additional, Landi, Alessia, additional, Witkowski, Wojciech, additional, Baeyens, Ann, additional, Kirchhoff, Frank, additional, and Verhasselt, Bruno, additional

Published
2016
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12. Cocirculation of Two env Molecular Variants, of Possible Recombinant Origin, in Gorilla and Chimpanzee Simian Foamy Virus Strains from Central Africa

Author

Richard, Léa, primary, Rua, Réjane, additional, Betsem, Edouard, additional, Mouinga-Ondémé, Augustin, additional, Kazanji, Mirdad, additional, Leroy, Eric, additional, Njouom, Richard, additional, Buseyne, Florence, additional, Afonso, Philippe V., additional, and Gessain, Antoine, additional

Published
2015
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15. HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4+ T Cells.

Author

Vermeire, Jolien, Roesch, Ferdinand, Sauter, Daniel, Rua, Réjane, Hotter, Dominik, Van Nuffel, Anouk, Vanderstraeten, Hanne, Naessens, Evelien, Iannucci, Veronica, Landi, Alessia, Witkowski, Wojciech, Baeyens, Ann, Kirchhoff, Frank, and Verhasselt, Bruno

Abstract

Summary Several pattern-recognition receptors sense HIV-1 replication products and induce type I interferon (IFN-I) production under specific experimental conditions. However, it is thought that viral sensing and IFN induction are virtually absent in the main target cells of HIV-1 in vivo. Here, we show that activated CD4 + T cells sense HIV-1 infection through the cytosolic DNA sensor cGAS and mount a bioactive IFN-I response. Efficient induction of IFN-I by HIV-1 infection requires proviral integration and is regulated by newly expressed viral accessory proteins: Vpr potentiates, while Vpu suppresses cGAS-dependent IFN-I induction. Furthermore, Vpr also amplifies innate sensing of HIV-1 infection in Vpx-treated dendritic cells. Our results identify cGAS as mediator of an IFN-I response to HIV-1 infection in CD4 + T cells and demonstrate that this response is modulated by the viral accessory proteins Vpr and Vpu. Thus, viral innate immune evasion is incomplete in the main target cells of HIV-1. [ABSTRACT FROM AUTHOR]

Published
2016
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20. HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4+T Cells

Author

Vermeire, Jolien, Roesch, Ferdinand, Sauter, Daniel, Rua, Réjane, Hotter, Dominik, Van Nuffel, Anouk, Vanderstraeten, Hanne, Naessens, Evelien, Iannucci, Veronica, Landi, Alessia, Witkowski, Wojciech, Baeyens, Ann, Kirchhoff, Frank, and Verhasselt, Bruno

Abstract

Several pattern-recognition receptors sense HIV-1 replication products and induce type I interferon (IFN-I) production under specific experimental conditions. However, it is thought that viral sensing and IFN induction are virtually absent in the main target cells of HIV-1 in vivo. Here, we show that activated CD4+T cells sense HIV-1 infection through the cytosolic DNA sensor cGAS and mount a bioactive IFN-I response. Efficient induction of IFN-I by HIV-1 infection requires proviral integration and is regulated by newly expressed viral accessory proteins: Vpr potentiates, while Vpu suppresses cGAS-dependent IFN-I induction. Furthermore, Vpr also amplifies innate sensing of HIV-1 infection in Vpx-treated dendritic cells. Our results identify cGAS as mediator of an IFN-I response to HIV-1 infection in CD4+T cells and demonstrate that this response is modulated by the viral accessory proteins Vpr and Vpu. Thus, viral innate immune evasion is incomplete in the main target cells of HIV-1.

Published
2016
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