11 results on '"Ružman, Tomislav"'
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2. Usporedba regionalne cerebralne saturacije u inhalacijskoj i intravenskoj anesteziji kod laparoskopskih operacija odstranjenja žučnog mjehura
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Ružman, Tomislav
- Subjects
laparoskopija ,kolecistektomija ,oksigenacija mozga ,propofol ,sevofluran ,NIRS - Abstract
Pozadina istraživanja: Tijekom različitih kirurških zahvata anesteziolozi se susreću s bolesnicima rizičnim za razvoj perioperacijske cerebralne hipoksije i ishemije. Neželjeno smanjenje oksigenacije mozga može uzrokovati neurokognitivne poremećaje ili cerebrovaskularne incidente koji se mogu javiti vrlo rano nakon oporavka iz anestezije. Cilj studije: Utvrditi moguće učinke dviju različitih tehnika anestezije: potpune intravenske anestezije s propofolom (TIVA) i anestezije uz uvod i vođenje inhalacijskim anestetikom sevofluranom (VIMA) na regionalnu cerebralnu oksigenaciju tijekom laparoskopskih operacija odstranjenja žučnjaka. Ustroj studije: Istraživanje je ustrojeno po načelu randomiziranoga kliničkog pokusa, a obavljeno je od ožujka 2013. do srpnja 2014. godine. Ispitanici i metode: U studiju su prospektivno uključeni ispitanici ASA I i II rizika kod kojih je predviđeno odstranjenje žučnoga mjehura laparoskopskom tehnikom u općoj anesteziji. Ovisno o tehnici anestezije ispitanici su podijeljeni u dvije skupine: TIVA i VIMA skupina. Tijekom anestezije i operacijskoga zahvata rabio se standardni neinvazivni monitoring (elektrokardiogram, kontinuirano neinvazivno mjerenje arterijskoga krvnog tlaka, zasićenost periferne krvi kisikom i bispektralni indeks). Regionalna cerebralna saturacija mjerena je s pomoću INVOS 5100 uređaja na objema frontalnim regijama glave. Demografski podatci i opće osobitosti ispitanika zabilježeni su prije anestezije. Vrijednost regionalne cerebralne saturacije, intraabdominalnoga tlaka, temperature, srednjega arterijskog tlaka, frekvencije pulsa te podatci o ventilaciji i oksigenaciji bilježeni su tijekom različitih vremenskih točaka anestezije i kirurškog postupka. Podatci o operacijskome zahvatu i poslijeoperacijskim komplikacijama zabilježeni su u sobi za oporavak i trećega dana nakon operacije. Rezultati: Istraživanje je provedeno na 124 ispitanika: 62 ispitanika u skupini TIVA i 62 ispitanika u skupini VIMA. Skupine se nisu razlikovale s obzirom na osnovne karakteristike. Bazalne vrijednosti rSO2 bile su vrlo široko raspršene (46-87%) između ispitanika i strana glave. Zabilježili smo značajan pad vrijednosti rSO2 nakon upuhivanja CO2 i postavljanja ispitanika u obrnuti Trendelenburgov položaj. Negativne promjene regionalne cerebralne oksigenacije znatno su češće u osoba starije životne dobi u vremenima TCO2 L (p=0, 012), TatCO2 L (p=0, 030) i Tpost L (p=0, 001) kao i u onih s većim indeksom tjelesne mase u mjerenim vremenima TCO2 L (p=0, 045), TatCO2 L (p=0, 041), Tind D (p=0, 045), TCO2 D (p=0, 027) i TatCO2 D (p=0, 012). Također, nakon ispuhivanja CO2 i vraćanja ispitanika u neutralan položaj vrijednosti su rSO2 porasle. Statistički značajno više vrijednosti rSO2 zabilježene su gotovo u svim fazama nakon uvoda u anesteziju u VIMA skupini ispitanika. Broj kritičnih padova rSO2 vrijednosti bio je statistički manji u skupini VIMA. Obje anesteziološke tehnike osigurale su dobru hemodinamsku stabilnost, no u trenutku maksimalno povećanoga intraabdominalnog tlaka učestalost hipertenzivnih reakcija bila je značajno manja u skupini anesteziranoj sevofluranom. U poslijeoperacijskome razdoblju nismo utvrdili značajnije komplikacije. Zaključak: Inhalacijska anestezija sevofluranom osigurava značajno više vrijednosti rSO2 za vrijeme svih razdoblja anestezije i operacije, osigurava manji broj kritičnih padova vrijednosti rSO2 i podržava dobru hemodinamsku stabilnost.
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- 2017
3. Transcranial Cerebral Oxymetric Monitoring Reduces Brain Hypoxia in Obese and Elderly Patients Undergoing General Anesthesia for Laparoscopic Cholecystectomy
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Ružman, Tomislav, primary, Mraović, Boris, additional, Šimurina, Tatjana, additional, Gulam, Danijela, additional, Ružman, Nataša, additional, and Miškulin, Maja, additional
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- 2017
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4. Sevoflurane preserves regional cerebral oxygen saturation better than propofol: Randomized controlled trial
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Ružman, Tomislav, primary, Šimurina, Tatjana, additional, Gulam, Danijela, additional, Ružman, Nataša, additional, and Miškulin, Maja, additional
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- 2017
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5. Prevalencija i rizični čimbenici kolonizacije cerviksa Ureaplasmom urealyticum u trudnica s područja Osječko-baranjske županije
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Ružman, Nataša, Miškulin, Maja, Ružman, Tomislav, Miškulin, Maja, and Kolarić, Branko
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trudnoća ,prevencija ,rizični čimbenici ,Ureaplasma urealyticum - Abstract
Cilj: Ispitati učestalost te utvrditi najznačajnije rizične čimbenike za nastanak kolonizacije cerviksa Ureaplasmom urealyticum među trudnicama s područja Osječko-baranjske županije. Metode: Ovo presječno istraživanje provedeno je u razdoblju od ožujka 2010. do travnja 2011. godine te je uključilo ukupno 456 trudnica u prvom i drugom trimestru trudnoće. Tijekom redovitih prenatalnih pregleda u ordinacijama njihovih ginekologa u primarnoj zdravstvenoj zaštiti svakoj trudnici učinjen je obrisak cerviksa koji je analiziran na prisustvo Ureaplasme urealyticum u Zavodu za javno zdravstvo Osječko-baranjske županije. Za detekciju Ureaplasme urealyticum korišten je Mycoplasma Duo kit (Bio Rad). Uz mikrobiološku analizu obriska cerviksa, sve ispitanice bile su zamoljene za ispunjavanje anonimnog anketnog upitnika kojim su se prikupili njihovi demografski podatci, podatci iz ginekološke anamneze te podatci o njihovoj izloženosti pojedinim rizičnim čimbenicima za nastanak kolonizacije cerviksa Ureaplasmom urealyticum. Rezultati: Među svim ispitanicama bilo je 35, 5% (162/456) trudnica pozitivnih na Ureaplasmu urealyticum. Pozitivnost je bila utvrđena kod 31, 8% (120/377) trudnica koje su bile u braku te 53, 2% (42/79) trudnica koje nisu bile u braku i ta razlika je bila statistički značajna (χ2=12, 979 ; df=1 ; p
- Published
- 2015
6. Promjene pulsa i arterijskog tlaka anesteziologa u Kliničkom bolničkom centru Osijek tijekom dežurstva i slobodnog dana
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Haršanji Drenjančević Ivana, Drenjančević, Domagoj, Ružman, Tomislav, and Gulam, Danijela
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- 2014
7. Our experience with sugammadex, new antagonist of muscle relaxants
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Kvolik, Slavica, Ružman, Tomislav, Kristek, Jozo, Nančeva, Jasminka, and Šošolčeva, Mirjana
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Neuromuscular blockade ,General anesthesia ,antagonists ,Sugammadex ,Neostigmine ,Thyroidectomy - Abstract
Background: Sugammadex is a new drug for neuromuscular block reversion. It is cyclic oligosaccharide, a gamma cyclodextrin with lipophylic inner coat that enables forming of stable complexes with steroidal neuromuscular blocking drugs, especially with rocuronium. In two groups of thyroid cancer patients we compared the effects of sugammadex and neostigmine for reversion of moderate block. Methods: All patients were mechanically ventilated with O2:N20 35:65 vol%. Muscle relaxation was measured using TOF-Watch. Both neostigmine with atropine and sugammadex were administered at the end of procedure. A recovery of TOF >90%, minute ventilation and the need for postoperative oxygenation were registered in the both groups. Statistical analysis was done using Chi-square and Student's t test. Results. Mean age, BMI and duration of surgery did not differ between two groups. A mean recovery time to TOF>0.9 was significantly longer in the neostigmine group as compared to the sugammadex (>15 min vs. 2.5, p0.9 and minute ventilation, enabling early neurological assessment, and shorter recovery time as compared to neostigmine.
- Published
- 2010
8. Postoperative wound infiltration with levobupivacaine 0.5% via PCA pump and in bolus doses does not impair hand grip strength
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Kvolik , Slavica, Djapić , Dajana, Kristek , Dalibor, Horvat , Vlado, Kristič , Marica, and Ružman, Tomislav
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analgesia ,postoperative ,breast cancer ,anesthesia ,localanalgesia - Abstract
Postoperative wound infiltration with local anesthetic delivered in the proximity of brachial plexus may produce hand weakness. An aim of this study was to evaluate hand grip strength in the women undergoing breast cancer surgery with axillary lymph node dissection and postoperative wound infiltration analgesia. We compared two postoperative wound infiltration groups with levobupivacaine 0.5%: the patient controlled analgesia group (PCA) and bolus group. Our study confirmed that both analgesic regimens were effective and well tolerated. Hand grip strength was not clinically impaired in any group.
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- 2010
9. Premedication with midazolam is equally effective via the sublingual and intravenous route of administration.
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RUŽMAN, TOMISLAV, KREŠIĆ, MARINA, IVIĆ, DUBRAVKA, GULAM, DANIJELA, RUŽMAN, NATAŠA, and BURAZIN, JELENA
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PREMEDICATION , *MIDAZOLAM , *INTRAVENOUS drug abuse , *DRUG administration , *DRUG efficacy - Abstract
Background: The aim of this study was to investigate the clinical efficacy and potential side effects of sublingual midazolam, used for premedication, in comparison with intravenous midazolam. The second aim was to explore cost-effectiveness of sublingual midazolam administration. Methods: A prospective, randomized, controlled, single-blinded trial was conducted at the Clinical Hospital Centre Osijek, Croatia, during the period 1st of May till 31st of October, 2012. We enrolled 140 patients (American Society of Anesthesio-logists (ASA) physical status I-II, age>18 years) scheduled for some kind of elective surgical procedure. Exclusion criteria were ASA III or higher, psychiatric disorders, allergy to midazolam and use of psychotropic drugs. Patients were randomi-zed into one of two groups. One group received 2.5 mg of midazolam intravenously and the other group received 1/4 of a midazolam tablet (approximately 3.75 mg) sublingually. Sedation was clinically evaluated using the Ramsey sedation scale at 0, 10, 20 and 30 minutes after drug administration. We also noted side effects and degree of amnesia. Results: Ten minutes after administration of premedication, a significantly higher number of patients in the intravenous group had a Ramsey score of 2 (p=0.000). Ten and twenty minutes after drug administration, most of the patients in the sublingual group had a Ramsey score 1-2, and after 30 minutes most of them had a Ramsey score 2-3, which is comparable with the intravenous (p=0.642) group. Conclusion: Sublingual application of midazolam has an equivalent sedative effect as intravenous midazolam 20 minutes after administration but is associated with a bitter taste and weaker amnestic effect. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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10. Osobitosti unutarbolničkog srčanog zastoja i reanimacijskog postupka.
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Ružman, Tomislav, Ivić, Dubravka, Ikić, Višnja, Ivić, Josip, and Pelc, Boris
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MEDICAL care , *HEART failure , *RESUSCITATION , *CARDIOPULMONARY resuscitation , *HEART disease related mortality , *INFECTIOUS disease transmission , *ANESTHESIOLOGY , *CARDIOPULMONARY system , *INTENSIVE care units - Abstract
Aim We have studied epidemiology of in-hospital cardiac arrest, characteristics of organizing a reanimation and its,procedures as well as its documenting. Methods We analyzed all resuscitation procedure data where anesthesiology reanimation teams (RT) provided cardiopulmonary resuscitation (CPR) during one-year period. We included resuscitation attempts that were initiated outside the Department of Anesthesiology, excluding incidents in operation rooms and Intensive Care Unit (ICU). Data on every cardiac arrest and CPR were entered in a special form. Results During one-year period 87 CPR were performed. Victims of cardiac arrest were principally elderly patients (age 60 - 80), mostly male (60%). Most frequent victims were neurological patients (42%), surgical patients (21%) and neurosurgical patients (10%). The leading cause of cardiac arrest was primary heart disease, following neurological diseases and respiration disorders of severe etiology. In over 90% cases CPR was initiated by medical personnel in their respective departments, RT arrived within 5 minutes in 73,56% cases. Initially survival was 32%, but full recovery was accomplished in 4 patients out of 87 (4,6%). Conclusion Victims of cardiac arrest are patients whose primary disease contributes to occurrence of cardiorespiratory complications. High mortality and low percentage of full recovery can be explained by characteristics of patients (old age, nature and seriousness of primary disease) which significantly affect the outcome of CPR. In some cases a question is raised whether to initiate the CPR at all. We would like to point out that continous monitoring of potentially critical patients may prevent cardiorespiratory incidents whereas the quality and success of CPR may be improved by training of staff and better technical equipment on the relevant locations in the in the hospital where such incidents usually occur. [ABSTRACT FROM AUTHOR]
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- 2009
11. Factors associated with difficult neuraxial blockade.
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Ružman T, Gulam D, Haršanji Drenjančević I, Venžera-Azenić D, Ružman N, and Burazin J
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Spinal and epidural blocks are common practice in anesthesia and are usually used for various surgical or endoscopic procedures. Correct identification and puncture of the epidural or subarachnoid space determine the success or failure of the technique. Multiple attempts and difficult access to the epidural or subarachnoid space is a frequent problem in operating theaters and may be hazardous due to a number of possible acute or long-term complications. In addition, multiple punctures are associated with increased pain and patient discomfort. The aim of this study was to determine the factors associated with a difficult spinal or epidural block, dependent on the patient (age, gender, height, weight, body mass index, and quality of anatomical landmarks), the technique (type of blockade, needle gauge, and patient positioning), and the provider (level of experience). The study was conducted at the Department of Anesthesiology, Resuscitation, and Intensive Care Unit of University Hospital Osijek (Osijek, Croatia) and it included 316 patients who underwent a range of different surgical procedures in neuraxial blocks. There were 219 cases of first puncture success, while the overall success of neuraxial blocks was 97.5%. Five patients (1.6%) were submitted to the alternative technique, ie, general anesthesia. In three patients (0.9%), neuraxial block was partial so they required supplementation of intravenous anesthetics and analgesics. Furthermore, it was found that first puncture success was associated with younger age (P=0.007), lower weight (P=0.032), and body mass index (P=0.020). Spine deformity (P=0.015), poor identification of interspinous space (P=0.005), recumbent patient position during the puncture (P=0.001), and use of a paramedian approach were associated with first puncture failure. Adequate preoperative prediction of difficulties can help to reduce the incidence of multiple attempts, rendering the technique more acceptable and less risky to the patient, and consequently leading to improvement of medical care quality. The attending anesthesiologist should consider an alternative technique (general anesthesia or peripheral nerve block) for a patient if certain difficulties can be predicted.
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- 2014
- Full Text
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