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Background. The optimal timing for aortic valve replacement (AVR) in aortic stenosis (AS) is still controversial and may be guided by markers of adverse left ventricular (LV) remodeling. We aim to assess electrocardiographic (ECG) strain patterns in relation to adverse LV remodeling and myocardial fibrosis. Methods. A total of 83 symptomatic severe AS patients (age 66.5 ± 8.6, 42% male) scheduled for surgical AVR underwent preoperative cardiovascular magnetic resonance (CMR) with T1 mapping and echocardiography with global longitudinal strain (GLS) analysis. Collagen volume fraction (CVF) was measured in myocardial biopsies (71) sampled at the time of AVR. The 12-lead ECG was performed preoperatively and 3 and 12 months postoperatively. Results. ECG strain-positive patients (prevalence of 43.4%) had more severe AS, increased LV mass, higher levels of brain natriuretic peptides (BNP) and high-sensitivity troponin I, lower GLS, and lower LV ejection fraction (LVEF). Patients with ECG strain had more diffuse fibrosis, as evident by higher native T1 values (974.8 ± 33.6 ms vs 946.5 ± 28.2 ms, p

Įvadas. Vis populiarėja galūnės kraujotakos atkūrimas pagal angiosomas, esant kritinei galūnės išemijai, t. y. revaskuliarizuojama būtent ta kraujagyslė, kuri maitina pažeistą plotą. Tačiau revaskuliarizacija atsižvelgiant į angiosomas nėra laikoma kritinės galūnių išemijos gydymo standartu, nes mokslinėje literatūroje trūksta įrodymų, pagrindžiančių šio gydymo metodo pranašumus. Pristatomo tyrimo tikslas – palyginti audinių oksigenacijos pokyčius išeminėje zonoje, endovaskuliniu būdu atkūrus kraujotaką tiesiogiai pagal angiosomą ir netiesiogiai. Metodai. Tai perspektyvusis stebimasis tyrimas. Į tyrimą įtraukti pacientai, kuriems diagnozuota kritinė galūnės išemija, esant gangrenai dėl užakusių blauzdos arterijų. Pacientams taikyta endovaskulinė revaskuliarizacija. Procedūros metu oksigenacijos pokyčiai stebėti naudojant artimųjų infraraudonųjų spindulių spektroskopiją. Gauti rezultatai lyginti pacientų, kuriems taikyta tiesioginė ir netiesioginė revaskuliarizacija, grupėse. Rezultatai. Tiriamąją imtį sudarė 30 pacientų, sergančių kritine galūnių išemija (5 Rutherfordo kategorija). Visiems pacientams nustatyta blauzdos arterijų okliuzija, kai reikia atkurti kraujotaką. Tyrimo metu 15 pacientų (50 %) kraujotaka buvo atkurta pagal angiosomą, tokiai pat daliai pacientų (50 %) – ne pagal angiosomą. Visiems tiriamiesiems procedūros metu matuoti oksigenacijos pokyčiai išeminėje zonoje. Didesnis oksigenacijos pokytis pastebėtas pacientų, kuriems atlikta revaskuliarizacija pagal angiosomą, grupėje (atitinkamai 29 proc. ir 23 proc.), bet statistiškai reikšmingo oksigenacijos skirtumo tarp grupių nenustatyta (nepriklausomos grupės t testas, p = 0,544). Išvados. Klinikinio tyrimo metu audinių oksigenacijos pokytis atkuriant kraujotaką pagal angiosomą mažai skyrėsi nuo audinių oksigenacijos pokyčio atkuriant kraujotaką ne pagal angiosomą. Skirtumas nebuvo statistiškai reikšmingas., Background. Blood flow restore in critical limb ischemia according to angiosomes is becoming very popular. This method allows to restore blood flow precisely to the artery supplying the ischemic zone, based on the angiosome concept. However, angiosome revascularization is not a gold standard because of the lack of evidence supporting this approach. The aim of this study was to compare tissue oxygenation changes in ischemic zone during endovascular revascularization procedure either following angiosome concept or performing indirect revascularization. Methods. A prospective observational study was performed. Patients with critical limb ischemia and tissue loss due to chronic total occlusion of below the knee arteries were included. Endovascular revascularization was performed in all cases. Tissue oxygen saturation was observed intraoperatively using near-infrared spectroscopy. Tissue oxygenation changes near the ischemic wound were compared between direct and indirect revascularization groups. Results. This clinical trial included 30 patients with critical limb ischemia (Rutherford 5) and occluded below the knee arteries intended to treat. In 15 patients the procedure was performed according to angiosome, while the other half underwent indirect revascularization. Tissue oxygenation near the wound was monitored during the intervention. Greater oxygen saturation increase was observed in the group with direct revascularization (29% and 23% accordingly), however the difference between groups was not statistically significant (t-test for independent group, p = 0,544). Conclusions. The increase in tissue oxygen saturation differed very slightly in direct and indirect revascularization groups and the difference was statistically insignificant.

To the date efficacy and safety between surgical ans catheter-based paravalvular mitral valve leak treatment is not well investigated. Objektive of thid study was to compare efficacy and safety between two treatment methods of mitral valve paravalvular leak.

Transapical off-pump implantation of artificial mitral valve chordae using NeoChord DS1000 device is an alternative approach to treat severe mitral regurgitation

Habilitacijos procedūrai teikiamoje mokslo darbų apžvalgoje apibendrinama Vilniaus universiteto Širdies ir kraujagyslių ligų klinikoje taikyto sunkaus širdies nepakankamumo gydymo patirtis. Įrodytas intraaortinės kontrapulsacijos balionėliu taikymo tikslingumas pacientams su dekompensuota dilatacine kardiomiopatija. Įvertintas dirbtinių skilvelių, kaip tilto į transplantaciją ar likimo terapiją efektyvumas. Nustatyta, kaip techniniai dirbtinių skilvelių pakeitimai gali daryti įtaką gydymo rezultatams. Ištirtas dirbtinių skilvelių poveikis recipiento imuninei sistemai prieš ir po transplantacijos. Apžvelgti alternatyvūs širdies transplantacijai chirurginiai gydymo metodai. Pasiūlyta originali modifikuotos labirinto operacijos technika, įvertintas jos saugumas, efektyvumas ir galimybė derinti su kitomis širdies operacijomis. Prognozuojamos ateities tendencijos labai sunkiam širdies nepakankamumui gydyti. Šiame darbe remiamasi kartu su bendraautoriais atliktų tyrimų 2001-2009 m. rezultatais. Autorius visuose apžvelgiamuose tyrimuose dalyvavo tiesiogiai, kaip padalinio, kuriame gydomi pacientai su labai sunkiu širdies nepakankamumu, vadovas ir kaip chirurgas. Remiantis publikuota medžiaga buvo daryti pranešimai ir Lietuvoje, ir užsienyje. The experience of treatment of end-stage heart failure cumulated at Vilnius University Cardiovascular Surgery Clinic is provided for habilitation procedure. The experience of intraaortic balloon counterpulsation for the patients suffering from decompensated dilatative cardiomyopathy has been proven. The efficacy of artificial ventricular assist devices as a bridge to transplantation or destination therapy has been evaluated. The role of technical modifications of ventricular assist devices for the outcomes of treatment has been assessed. The impact of assist devices on the immune status of the patient pre- and post-transplantation has also been evaluated. The alternative methods of treatment instead of heart transplantation are reviewed. The original technique of modified maze procedure is proposed; the safety, efficacy and possibilities of combining this technique with other heart operations are assessed. The future trends for treatment of end-stage heart failure are predicted. This study is based on the investigations performed with co-authors during the period since 2001 to 2009. The author has participated directly in all reviewed investigations as the head of the department where patients suffering from end-stage heart failure are being treated and as well as a surgeon. The reports based on the published material have been presented in Lithuania and abroad.

The experience of treatment of end-stage heart failure cumulated at Vilnius University Cardiovascular Surgery Clinic is provided for habilitation procedure. The experience of intraaortic balloon counterpulsation for the patients suffering from decompensated dilatative cardiomyopathy has been proven. The efficacy of artificial ventricular assist devices as a bridge to transplantation or destination therapy has been evaluated. The role of technical modifications of ventricular assist devices for the outcomes of treatment has been assessed. The impact of assist devices on the immune status of the patient pre- and post-transplantation has also been evaluated. The alternative methods of treatment instead of heart transplantation are reviewed. The original technique of modified maze procedure is proposed; the safety, efficacy and possibilities of combining this technique with other heart operations are assessed. The future trends for treatment of end-stage heart failure are predicted. This study is based on the investigations performed with co-authors during the period since 2001 to 2009. The author has participated directly in all reviewed investigations as the head of the department where patients suffering from end-stage heart failure are being treated and as well as a surgeon. The reports based on the published material have been presented in Lithuania and abroad.

Cytomegalovirus infection can cause lesions of different organs, including gastrointestinal tract. In transplant patients, CMV infection can be associated with severe consequences. This case details the clinical and diagnostic features of gastrointestinal CMV disease in a patient after heart transplantation, in which treatment resulted in a complete resolution of the symptoms.