1. Measures of Maternal Metabolic Health as Predictors of Severely Low Milk Production.
- Author
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Nommsen-Rivers, Laurie, Wagner, Erin, Roznowski, Dayna, Riddle, Sarah, Ward, Laura, and Thompson, Amy
- Subjects
human lactation ,insufficient milk ,insulin resistance ,low milk supply ,metabolic health ,metabolic syndrome ,Animals ,Breast Feeding ,Case-Control Studies ,Diabetes ,Gestational ,Female ,Humans ,Infant ,Metabolic Syndrome ,Milk ,Milk ,Human ,Pregnancy ,Prospective Studies - Abstract
Background: A comprehensive approach to breastfeeding support requires elucidation of how metabolic health influences milk production. Objective: We compared metabolic health indicators in women with severely low milk output versus those with moderate/normal milk output using a case-control study design, with nested and external control groups. Design: Cases and nested controls were derived from women screened for a low milk supply trial, with cases defined as severely low milk output (300 mL/24 hours). In addition, we included an external control group of exclusively breastfeeding women. All were enrolled at 2-10 weeks postdelivery of a healthy term infant. Milk output and breast emptying frequency were recorded through test-weigh. Metabolic health variables included all components of the metabolic syndrome, homeostatic model assessment of insulin resistance (HOMA-IR), and diagnosis of gestational diabetes mellitus (GDM). Results: Maximum milk output, mL/24 hours, ranged as follows: 30-281 in cases (n = 18), 372-801 in nested controls (n = 12), and 661-915 in external controls (n = 12). Mean breast emptying frequency in cases was not significantly different from nested or external controls. All metabolic syndrome components and HOMA-IR were significantly worse in cases as compared with both nested and external control groups (p
- Published
- 2022