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1. Author Correction: Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammation

Author

Padmanabhan, Nisha, Kyon, Huang Kie, Boot, Arnoud, Lim, Kevin, Srivastava, Supriya, Chen, Shuwen, Wu, Zhiyuan, Lee, Hyung-Ok, Mukundan, Vineeth T., Chan, Charlene, Chan, Yarn Kit, Xuewen, Ong, Pitt, Jason J., Isa, Zul Fazreen Adam, Xing, Manjie, Lee, Ming Hui, Tan, Angie Lay Keng, Ting, Shamaine Ho Wei, Luftig, Micah A., Kappei, Dennis, Kruger, Warren D., Bian, Jinsong, Ho, Ying Swan, Teh, Ming, Rozen, Steve George, and Tan, Patrick

Published
2021
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2. Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammation

Author

Padmanabhan, Nisha, Kyon, Huang Kie, Boot, Arnoud, Lim, Kevin, Srivastava, Supriya, Chen, Shuwen, Wu, Zhiyuan, Lee, Hyung-Ok, Mukundan, Vineeth T., Chan, Charlene, Chan, Yarn Kit, Xuewen, Ong, Pitt, Jason J., Isa, Zul Fazreen Adam, Xing, Manjie, Lee, Ming Hui, Tan, Angie Lay Keng, Ting, Shamaine Ho Wei, Luftig, Micah A., Kappei, Dennis, Kruger, Warren D., Bian, Jinsong, Ho, Ying Swan, Teh, Ming, Rozen, Steve George, and Tan, Patrick

Published
2021
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5. Massively parallel sequencing of patients with intellectual disability, congenital anomalies and/or autism spectrum disorders with a targeted gene panel.

Author

Brett, Maggie, McPherson, John, Zang, Zhi Jiang, Lai, Angeline, Tan, Ee-Shien, Ng, Ivy, Ong, Lai-Choo, Cham, Breana, Tan, Patrick, Rozen, Steve, and Tan, Ene-Choo

Subjects
Humans, RNA Splice Sites, Gene Expression Profiling, DNA Mutational Analysis, Phenotype, Mutation, Polymorphism, Single Nucleotide, Female, Male, Congenital Abnormalities, Genetic Variation, Genome-Wide Association Study, Genetic Association Studies, High-Throughput Nucleotide Sequencing, Intellectual Disability, Autism Spectrum Disorder, Polymorphism, Single Nucleotide, General Science & Technology
Abstract

Developmental delay and/or intellectual disability (DD/ID) affects 1-3% of all children. At least half of these are thought to have a genetic etiology. Recent studies have shown that massively parallel sequencing (MPS) using a targeted gene panel is particularly suited for diagnostic testing for genetically heterogeneous conditions. We report on our experiences with using massively parallel sequencing of a targeted gene panel of 355 genes for investigating the genetic etiology of eight patients with a wide range of phenotypes including DD/ID, congenital anomalies and/or autism spectrum disorder. Targeted sequence enrichment was performed using the Agilent SureSelect Target Enrichment Kit and sequenced on the Illumina HiSeq2000 using paired-end reads. For all eight patients, 81-84% of the targeted regions achieved read depths of at least 20×, with average read depths overlapping targets ranging from 322× to 798×. Causative variants were successfully identified in two of the eight patients: a nonsense mutation in the ATRX gene and a canonical splice site mutation in the L1CAM gene. In a third patient, a canonical splice site variant in the USP9X gene could likely explain all or some of her clinical phenotypes. These results confirm the value of targeted MPS for investigating DD/ID in children for diagnostic purposes. However, targeted gene MPS was less likely to provide a genetic diagnosis for children whose phenotype includes autism.

Published
2014

8. Large-Scale Identification, Mapping, and Genotyping of Single-Nucleotide Polymorphisms in the Human Genome

Author

Wang, David G., Fan, Jian-Bing, Siao, Chia-Jen, Berno, Anthony, Young, Peter, Sapolsky, Ron, Ghandour, Ghassan, Perkins, Nancy, Winchester, Ellen, Spencer, Jessica, Kruglyak, Leonid, Stein, Lincoln, Hsie, Linda, Topaloglou, Thodoros, Hubbell, Earl, Robinson, Elizabeth, Mittmann, Michael, Morris, Macdonald S., Shen, Naiping, Kilburn, Dan, Rioux, John, Nusbaum, Chad, Rozen, Steve, Hudson, Thomas J., Lipshutz, Robert, Chee, Mark, and Lander, Eric S.

Published
1998

9. Data from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma

Author

Koo, Ghee Chong, primary, Tan, Soo Yong, primary, Tang, Tiffany, primary, Poon, Song Ling, primary, Allen, George E., primary, Tan, Leonard, primary, Chong, Soo Ching, primary, Ong, Whee Sze, primary, Tay, Kevin, primary, Tao, Miriam, primary, Quek, Richard, primary, Loong, Susan, primary, Yeoh, Kheng-Wei, primary, Yap, Swee Peng, primary, Lee, Kuo Ann, primary, Lim, Lay Cheng, primary, Tan, Daryl, primary, Goh, Christopher, primary, Cutcutache, Ioana, primary, Yu, Willie, primary, Young Ng, Cedric Chuan, primary, Rajasegaran, Vikneswari, primary, Heng, Hong Lee, primary, Gan, Anna, primary, Ong, Choon Kiat, primary, Rozen, Steve, primary, Tan, Patrick, primary, Teh, Bin Tean, primary, and Lim, Soon Thye, primary

Published
2023
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10. Supplementary Table 4 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma

Author

Koo, Ghee Chong, primary, Tan, Soo Yong, primary, Tang, Tiffany, primary, Poon, Song Ling, primary, Allen, George E., primary, Tan, Leonard, primary, Chong, Soo Ching, primary, Ong, Whee Sze, primary, Tay, Kevin, primary, Tao, Miriam, primary, Quek, Richard, primary, Loong, Susan, primary, Yeoh, Kheng-Wei, primary, Yap, Swee Peng, primary, Lee, Kuo Ann, primary, Lim, Lay Cheng, primary, Tan, Daryl, primary, Goh, Christopher, primary, Cutcutache, Ioana, primary, Yu, Willie, primary, Young Ng, Cedric Chuan, primary, Rajasegaran, Vikneswari, primary, Heng, Hong Lee, primary, Gan, Anna, primary, Ong, Choon Kiat, primary, Rozen, Steve, primary, Tan, Patrick, primary, Teh, Bin Tean, primary, and Lim, Soon Thye, primary

Published
2023
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11. Supplementary Table 3 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma

Author

Koo, Ghee Chong, primary, Tan, Soo Yong, primary, Tang, Tiffany, primary, Poon, Song Ling, primary, Allen, George E., primary, Tan, Leonard, primary, Chong, Soo Ching, primary, Ong, Whee Sze, primary, Tay, Kevin, primary, Tao, Miriam, primary, Quek, Richard, primary, Loong, Susan, primary, Yeoh, Kheng-Wei, primary, Yap, Swee Peng, primary, Lee, Kuo Ann, primary, Lim, Lay Cheng, primary, Tan, Daryl, primary, Goh, Christopher, primary, Cutcutache, Ioana, primary, Yu, Willie, primary, Young Ng, Cedric Chuan, primary, Rajasegaran, Vikneswari, primary, Heng, Hong Lee, primary, Gan, Anna, primary, Ong, Choon Kiat, primary, Rozen, Steve, primary, Tan, Patrick, primary, Teh, Bin Tean, primary, and Lim, Soon Thye, primary

Published
2023
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12. Supplementary Table 1 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma

Author

Koo, Ghee Chong, primary, Tan, Soo Yong, primary, Tang, Tiffany, primary, Poon, Song Ling, primary, Allen, George E., primary, Tan, Leonard, primary, Chong, Soo Ching, primary, Ong, Whee Sze, primary, Tay, Kevin, primary, Tao, Miriam, primary, Quek, Richard, primary, Loong, Susan, primary, Yeoh, Kheng-Wei, primary, Yap, Swee Peng, primary, Lee, Kuo Ann, primary, Lim, Lay Cheng, primary, Tan, Daryl, primary, Goh, Christopher, primary, Cutcutache, Ioana, primary, Yu, Willie, primary, Young Ng, Cedric Chuan, primary, Rajasegaran, Vikneswari, primary, Heng, Hong Lee, primary, Gan, Anna, primary, Ong, Choon Kiat, primary, Rozen, Steve, primary, Tan, Patrick, primary, Teh, Bin Tean, primary, and Lim, Soon Thye, primary

Published
2023
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13. Supplementary Figure 1 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma

Author

Koo, Ghee Chong, primary, Tan, Soo Yong, primary, Tang, Tiffany, primary, Poon, Song Ling, primary, Allen, George E., primary, Tan, Leonard, primary, Chong, Soo Ching, primary, Ong, Whee Sze, primary, Tay, Kevin, primary, Tao, Miriam, primary, Quek, Richard, primary, Loong, Susan, primary, Yeoh, Kheng-Wei, primary, Yap, Swee Peng, primary, Lee, Kuo Ann, primary, Lim, Lay Cheng, primary, Tan, Daryl, primary, Goh, Christopher, primary, Cutcutache, Ioana, primary, Yu, Willie, primary, Young Ng, Cedric Chuan, primary, Rajasegaran, Vikneswari, primary, Heng, Hong Lee, primary, Gan, Anna, primary, Ong, Choon Kiat, primary, Rozen, Steve, primary, Tan, Patrick, primary, Teh, Bin Tean, primary, and Lim, Soon Thye, primary

Published
2023
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14. Supplementary Table 2 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma

Author

Koo, Ghee Chong, primary, Tan, Soo Yong, primary, Tang, Tiffany, primary, Poon, Song Ling, primary, Allen, George E., primary, Tan, Leonard, primary, Chong, Soo Ching, primary, Ong, Whee Sze, primary, Tay, Kevin, primary, Tao, Miriam, primary, Quek, Richard, primary, Loong, Susan, primary, Yeoh, Kheng-Wei, primary, Yap, Swee Peng, primary, Lee, Kuo Ann, primary, Lim, Lay Cheng, primary, Tan, Daryl, primary, Goh, Christopher, primary, Cutcutache, Ioana, primary, Yu, Willie, primary, Young Ng, Cedric Chuan, primary, Rajasegaran, Vikneswari, primary, Heng, Hong Lee, primary, Gan, Anna, primary, Ong, Choon Kiat, primary, Rozen, Steve, primary, Tan, Patrick, primary, Teh, Bin Tean, primary, and Lim, Soon Thye, primary

Published
2023
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15. Supplementary Figure S3 from Integrative Analysis of Head and Neck Cancer Identifies Two Biologically Distinct HPV and Three Non-HPV Subtypes

Author

Keck, Michaela K., primary, Zuo, Zhixiang, primary, Khattri, Arun, primary, Stricker, Thomas P., primary, Brown, Christopher D., primary, Imanguli, Matin, primary, Rieke, Damian, primary, Endhardt, Katharina, primary, Fang, Petra, primary, Brägelmann, Johannes, primary, DeBoer, Rebecca, primary, El-Dinali, Mohamed, primary, Aktolga, Serdal, primary, Lei, Zhengdeng, primary, Tan, Patrick, primary, Rozen, Steve G., primary, Salgia, Ravi, primary, Weichselbaum, Ralph R., primary, Lingen, Mark W., primary, Story, Michael D., primary, Ang, K. Kian, primary, Cohen, Ezra E.W., primary, White, Kevin P., primary, Vokes, Everett E., primary, and Seiwert, Tanguy Y., primary

Published
2023
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16. Supplementary Table S2 from Integrative Analysis of Head and Neck Cancer Identifies Two Biologically Distinct HPV and Three Non-HPV Subtypes

Author

Keck, Michaela K., primary, Zuo, Zhixiang, primary, Khattri, Arun, primary, Stricker, Thomas P., primary, Brown, Christopher D., primary, Imanguli, Matin, primary, Rieke, Damian, primary, Endhardt, Katharina, primary, Fang, Petra, primary, Brägelmann, Johannes, primary, DeBoer, Rebecca, primary, El-Dinali, Mohamed, primary, Aktolga, Serdal, primary, Lei, Zhengdeng, primary, Tan, Patrick, primary, Rozen, Steve G., primary, Salgia, Ravi, primary, Weichselbaum, Ralph R., primary, Lingen, Mark W., primary, Story, Michael D., primary, Ang, K. Kian, primary, Cohen, Ezra E.W., primary, White, Kevin P., primary, Vokes, Everett E., primary, and Seiwert, Tanguy Y., primary

Published
2023
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17. Supplemental Materials and Legend from Integrative Analysis of Head and Neck Cancer Identifies Two Biologically Distinct HPV and Three Non-HPV Subtypes

Author

Keck, Michaela K., primary, Zuo, Zhixiang, primary, Khattri, Arun, primary, Stricker, Thomas P., primary, Brown, Christopher D., primary, Imanguli, Matin, primary, Rieke, Damian, primary, Endhardt, Katharina, primary, Fang, Petra, primary, Brägelmann, Johannes, primary, DeBoer, Rebecca, primary, El-Dinali, Mohamed, primary, Aktolga, Serdal, primary, Lei, Zhengdeng, primary, Tan, Patrick, primary, Rozen, Steve G., primary, Salgia, Ravi, primary, Weichselbaum, Ralph R., primary, Lingen, Mark W., primary, Story, Michael D., primary, Ang, K. Kian, primary, Cohen, Ezra E.W., primary, White, Kevin P., primary, Vokes, Everett E., primary, and Seiwert, Tanguy Y., primary

Published
2023
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18. Supplementary Methods, Tables 1-4, Figures 1-14 from TP53 Genomic Status Regulates Sensitivity of Gastric Cancer Cells to the Histone Methylation Inhibitor 3-Deazaneplanocin A (DZNep)

Author

Cheng, Lai Ling, primary, Itahana, Yoko, primary, Lei, Zheng Deng, primary, Chia, Na-Yu, primary, Wu, Yonghui, primary, Yu, Yingnan, primary, Li Zhang, Shen, primary, Thike, Aye Aye, primary, Pandey, Anuradha, primary, Rozen, Steve, primary, Voorhoeve, Pieter Mathijs, primary, Yu, Qiang, primary, Tan, Puay Hoon, primary, Bay, Boon Huat, primary, Itahana, Koji, primary, and Tan, Patrick, primary

Published
2023
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19. Data from Genetic and Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing

Author

Zang, Zhi Jiang, primary, Ong, Choon Kiat, primary, Cutcutache, Ioana, primary, Yu, Willie, primary, Zhang, Shen Li, primary, Huang, Dachuan, primary, Ler, Lian Dee, primary, Dykema, Karl, primary, Gan, Anna, primary, Tao, Jiong, primary, Lim, Siyu, primary, Liu, Yujing, primary, Futreal, P. Andrew, primary, Grabsch, Heike, primary, Furge, Kyle A., primary, Goh, Liang Kee, primary, Rozen, Steve, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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20. Supplementary Figure 3 from Genetic and Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing

Author

Zang, Zhi Jiang, primary, Ong, Choon Kiat, primary, Cutcutache, Ioana, primary, Yu, Willie, primary, Zhang, Shen Li, primary, Huang, Dachuan, primary, Ler, Lian Dee, primary, Dykema, Karl, primary, Gan, Anna, primary, Tao, Jiong, primary, Lim, Siyu, primary, Liu, Yujing, primary, Futreal, P. Andrew, primary, Grabsch, Heike, primary, Furge, Kyle A., primary, Goh, Liang Kee, primary, Rozen, Steve, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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21. Supplementary Methods and Materials, Results, Legends for Tables 1-11 and Figures 1-3 from Genetic and Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing

Author

Zang, Zhi Jiang, primary, Ong, Choon Kiat, primary, Cutcutache, Ioana, primary, Yu, Willie, primary, Zhang, Shen Li, primary, Huang, Dachuan, primary, Ler, Lian Dee, primary, Dykema, Karl, primary, Gan, Anna, primary, Tao, Jiong, primary, Lim, Siyu, primary, Liu, Yujing, primary, Futreal, P. Andrew, primary, Grabsch, Heike, primary, Furge, Kyle A., primary, Goh, Liang Kee, primary, Rozen, Steve, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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22. Supplementary Figure 2 from Genetic and Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing

Author

Zang, Zhi Jiang, primary, Ong, Choon Kiat, primary, Cutcutache, Ioana, primary, Yu, Willie, primary, Zhang, Shen Li, primary, Huang, Dachuan, primary, Ler, Lian Dee, primary, Dykema, Karl, primary, Gan, Anna, primary, Tao, Jiong, primary, Lim, Siyu, primary, Liu, Yujing, primary, Futreal, P. Andrew, primary, Grabsch, Heike, primary, Furge, Kyle A., primary, Goh, Liang Kee, primary, Rozen, Steve, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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23. Supplementary Table 6 from Genetic and Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing

Author

Zang, Zhi Jiang, primary, Ong, Choon Kiat, primary, Cutcutache, Ioana, primary, Yu, Willie, primary, Zhang, Shen Li, primary, Huang, Dachuan, primary, Ler, Lian Dee, primary, Dykema, Karl, primary, Gan, Anna, primary, Tao, Jiong, primary, Lim, Siyu, primary, Liu, Yujing, primary, Futreal, P. Andrew, primary, Grabsch, Heike, primary, Furge, Kyle A., primary, Goh, Liang Kee, primary, Rozen, Steve, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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24. Supplementary Table 5 from Genetic and Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing

Author

Zang, Zhi Jiang, primary, Ong, Choon Kiat, primary, Cutcutache, Ioana, primary, Yu, Willie, primary, Zhang, Shen Li, primary, Huang, Dachuan, primary, Ler, Lian Dee, primary, Dykema, Karl, primary, Gan, Anna, primary, Tao, Jiong, primary, Lim, Siyu, primary, Liu, Yujing, primary, Futreal, P. Andrew, primary, Grabsch, Heike, primary, Furge, Kyle A., primary, Goh, Liang Kee, primary, Rozen, Steve, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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25. Supplementary Table 2 from Genetic and Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing

Author

Zang, Zhi Jiang, primary, Ong, Choon Kiat, primary, Cutcutache, Ioana, primary, Yu, Willie, primary, Zhang, Shen Li, primary, Huang, Dachuan, primary, Ler, Lian Dee, primary, Dykema, Karl, primary, Gan, Anna, primary, Tao, Jiong, primary, Lim, Siyu, primary, Liu, Yujing, primary, Futreal, P. Andrew, primary, Grabsch, Heike, primary, Furge, Kyle A., primary, Goh, Liang Kee, primary, Rozen, Steve, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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26. Supplementary Table 4 from Genetic and Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing

Author

Zang, Zhi Jiang, primary, Ong, Choon Kiat, primary, Cutcutache, Ioana, primary, Yu, Willie, primary, Zhang, Shen Li, primary, Huang, Dachuan, primary, Ler, Lian Dee, primary, Dykema, Karl, primary, Gan, Anna, primary, Tao, Jiong, primary, Lim, Siyu, primary, Liu, Yujing, primary, Futreal, P. Andrew, primary, Grabsch, Heike, primary, Furge, Kyle A., primary, Goh, Liang Kee, primary, Rozen, Steve, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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27. Supplementary Table 10 from Genetic and Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing

Author

Zang, Zhi Jiang, primary, Ong, Choon Kiat, primary, Cutcutache, Ioana, primary, Yu, Willie, primary, Zhang, Shen Li, primary, Huang, Dachuan, primary, Ler, Lian Dee, primary, Dykema, Karl, primary, Gan, Anna, primary, Tao, Jiong, primary, Lim, Siyu, primary, Liu, Yujing, primary, Futreal, P. Andrew, primary, Grabsch, Heike, primary, Furge, Kyle A., primary, Goh, Liang Kee, primary, Rozen, Steve, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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28. Supplementary Table 3 from Genetic and Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing

Author

Zang, Zhi Jiang, primary, Ong, Choon Kiat, primary, Cutcutache, Ioana, primary, Yu, Willie, primary, Zhang, Shen Li, primary, Huang, Dachuan, primary, Ler, Lian Dee, primary, Dykema, Karl, primary, Gan, Anna, primary, Tao, Jiong, primary, Lim, Siyu, primary, Liu, Yujing, primary, Futreal, P. Andrew, primary, Grabsch, Heike, primary, Furge, Kyle A., primary, Goh, Liang Kee, primary, Rozen, Steve, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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29. Supplementary Figure 1 from Genetic and Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing

Author

Zang, Zhi Jiang, primary, Ong, Choon Kiat, primary, Cutcutache, Ioana, primary, Yu, Willie, primary, Zhang, Shen Li, primary, Huang, Dachuan, primary, Ler, Lian Dee, primary, Dykema, Karl, primary, Gan, Anna, primary, Tao, Jiong, primary, Lim, Siyu, primary, Liu, Yujing, primary, Futreal, P. Andrew, primary, Grabsch, Heike, primary, Furge, Kyle A., primary, Goh, Liang Kee, primary, Rozen, Steve, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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30. Supplementary Table 8 from Genetic and Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing

Author

Zang, Zhi Jiang, primary, Ong, Choon Kiat, primary, Cutcutache, Ioana, primary, Yu, Willie, primary, Zhang, Shen Li, primary, Huang, Dachuan, primary, Ler, Lian Dee, primary, Dykema, Karl, primary, Gan, Anna, primary, Tao, Jiong, primary, Lim, Siyu, primary, Liu, Yujing, primary, Futreal, P. Andrew, primary, Grabsch, Heike, primary, Furge, Kyle A., primary, Goh, Liang Kee, primary, Rozen, Steve, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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31. Supplementary Table 9 from Genetic and Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing

Author

Zang, Zhi Jiang, primary, Ong, Choon Kiat, primary, Cutcutache, Ioana, primary, Yu, Willie, primary, Zhang, Shen Li, primary, Huang, Dachuan, primary, Ler, Lian Dee, primary, Dykema, Karl, primary, Gan, Anna, primary, Tao, Jiong, primary, Lim, Siyu, primary, Liu, Yujing, primary, Futreal, P. Andrew, primary, Grabsch, Heike, primary, Furge, Kyle A., primary, Goh, Liang Kee, primary, Rozen, Steve, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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32. Supplementary Table 7 from Genetic and Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing

Author

Zang, Zhi Jiang, primary, Ong, Choon Kiat, primary, Cutcutache, Ioana, primary, Yu, Willie, primary, Zhang, Shen Li, primary, Huang, Dachuan, primary, Ler, Lian Dee, primary, Dykema, Karl, primary, Gan, Anna, primary, Tao, Jiong, primary, Lim, Siyu, primary, Liu, Yujing, primary, Futreal, P. Andrew, primary, Grabsch, Heike, primary, Furge, Kyle A., primary, Goh, Liang Kee, primary, Rozen, Steve, primary, Teh, Bin Tean, primary, and Tan, Patrick, primary

Published
2023
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35. APCmosaicism, not always isolated: two first-degree relatives with apparently distinctAPCmosaicism

Author

Terlouw, Diantha, primary, Hes, Frederik J, additional, Suerink, Manon, additional, Boot, Arnoud, additional, Langers, Alexandra M J, additional, Tops, Carli M, additional, van Leerdam, Monique E, additional, van Asperen, Christi J, additional, Rozen, Steve G, additional, Bijlsma, Emilia K, additional, van Wezel, Tom, additional, Morreau, Hans, additional, and Nielsen, Maartje, additional

Published
2022
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37. A genomic‐augmented multivariate prognostic model for the survival of natural‐killer/T‐cell lymphoma patients from an international cohort

Author

Lim, Jing Quan, primary, Huang, Dachuan, additional, Chan, Jason Yongsheng, additional, Laurensia, Yurike, additional, Wong, Esther Kam Yin, additional, Cheah, Daryl Ming Zhe, additional, Chia, Burton Kuan Hui, additional, Chuang, Wen‐Yu, additional, Kuo, Ming‐Chung, additional, Su, Yi‐Jiun, additional, Cai, Qing‐qing, additional, Feng, Yanfen, additional, Rao, Huilan, additional, Feng, Li‐Na, additional, Wei, Pan‐Pan, additional, Chen, Jie‐Rong, additional, Han, Bo‐Wei, additional, Lin, Guo‐Wang, additional, Cai, Jun, additional, Fang, Yu, additional, Tan, Jing, additional, Hong, Huangming, additional, Liu, Yanhui, additional, Zhang, Fen, additional, Li, Wenyu, additional, Poon, Michelle L. M., additional, Ng, Siok‐Bian, additional, Jeyasekharan, Anand, additional, Ha, Jeslin Chian Hung, additional, Khoo, Lay Poh, additional, Chin, Suk Teng, additional, Pang, Wan Lu, additional, Kee, Rebecca, additional, Cheng, Chee Leong, additional, Grigoropoulos, Nicholas Francis, additional, Tang, Tiffany, additional, Tao, Miriam, additional, Farid, Mohamad, additional, Puan, Kia Joo, additional, Xiong, Jie, additional, Zhao, Wei‐Li, additional, Khor, Chiea Chuen, additional, Hwang, William, additional, Kim, Won Seog, additional, Campo, Elias, additional, Tan, Patrick, additional, Teh, Bin Tean, additional, Chng, Wee‐Joo, additional, Rötzschke, Olaf, additional, Tousseyn, Thomas, additional, Huang, Hui‐Qiang, additional, Rozen, Steve, additional, Lim, Soon Thye, additional, Shih, Lee‐Yung, additional, Bei, Jin‐Xin, additional, and Ong, Choon Kiat, additional

Published
2022
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41. Genetic characterization of a missense mutation in the X-linked TAF7L gene identified in an oligozoospermic man

Author

Ling, Li, primary, Li, Fangfang, additional, Yang, Pinglan, additional, Oates, Robert D, additional, Silber, Sherman, additional, Kurischko, Cornelia, additional, Luca, Francis C, additional, Leu, N Adrian, additional, Zhang, Jinwen, additional, Yue, Qiuling, additional, Skaletsky, Helen, additional, Brown, Laura G, additional, Rozen, Steve G, additional, Page, David C, additional, Wang, P Jeremy, additional, and Zheng, Ke, additional

Published
2022
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46. Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators

Author

Bellott, Daniel W., Hughes, Jennifer F., Skaletsky, Helen, Brown, Laura G., Pyntikova, Tatyana, Cho, Ting-Jan, Koutseva, Natalia, Zaghlul, Sara, Graves, Tina, Rock, Susie, Kremitzki, Colin, Fulton, Robert S., Dugan, Shannon, Ding, Yan, Morton, Donna, Khan, Ziad, Lewis, Lora, Buhay, Christian, Wang, Qiaoyan, Watt, Jennifer, Holder, Michael, Lee, Sandy, Nazareth, Lynne, Rozen, Steve, Muzny, Donna M., Warren, Wesley C., Gibbs, Richard A., Wilson, Richard K., and Page, David C.

Subjects
Spermatogenesis -- Research, Evolutionary biology -- Research, X chromosome -- Physiological aspects -- Research, Y chromosome -- Physiological aspects -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The human X and Y chromosomes evolved from an ordinary pair of autosomes, but millions of years ago genetic decay ravaged the Y chromosome, and only three per cent of its ancestral genes survived. We reconstructed the evolution of the Y chromosome across eight mammals to identify biases in gene content and the selective pressures that preserved the surviving ancestral genes. Our findings indicate that survival was nonrandom, and in two cases, convergent across placental and marsupial mammals. We conclude that the gene content of the Y chromosome became specialized through selection to maintain the ancestral dosage of homologous X-Ygene pairs that function as broadly expressed regulators of transcription, translation and protein stability. We propose that beyond its roles in testis determination and spermatogenesis, the Y chromosome is essential for male viability, and has unappreciated roles in Turner's syndrome and in phenotypic differences between the sexes in health and disease., The human X and Y chromosomes evolved from autosomes over the past 300 million years (1). Only 3% of ancestral genes survive on the human Y chromosome (2,3), compared to [...]

Published
2014
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47. Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development

Author

Chia, Na-Yu, Deng, Niantao, Das, Kakoli, Huang, Dachuan, Hu, Longyu, Zhu, Yansong, Lim, Kiat Hon, Lee, Ming-Hui, Wu, Jeanie, Sam, Xin Xiu, Tan, Gek San, Wan, Wei Keat, Yu, Willie, Gan, Anna, Tan, Angie Lay Keng, Tay, Su-Ting, Soo, Khee Chee, Wong, Wai Keong, Dominguez, Lourdes Trinidad M, Ng, Huck-Hui, Rozen, Steve, Goh, Liang-Kee, Teh, Bin-Tean, and Tan, Patrick

Published
2015
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48. An STS-Based Map of the Human Genome

Author

Hudson, Thomas J., Stein, Lincoln D., Gerety, Sebastian S., Ma, Junli, Castle, Andrew B., Silva, James, Slonim, Donna K., Baptista, Rafael, Kruglyak, Leonid, Xu, Shu-Hua, Hu, Xintong, Rosenberg, Carl, Reeve-Daly, Mary Pat, Rozen, Steve, Hui, Lester, Wu, Xiaoyun, Vestergaard, Christina, Wilson, Kimberly M., Bae, Jane S., Maitra, Shanak, Ganiatsas, Soula, Evans, Cheryl A., DeAngelis, Margaret M., Ingalls, Kimberly A., Nahf, Robert W., Horton, Lloyd T., Anderson, Michele Oskin, Collymore, Alville J., Ye, Wenjuan, Kouyoumjian, Vardouhie, Zemsteva, Irena S., Tam, James, Devine, Richard, Courtney, Dorothy F., Renaud, Michelle Turner, Nguyen, Huy, O'Connor, Tara J., Fizames, Cécile, Fauré, Sabine, Gyapay, Gabor, Dib, Colette, Morissette, Jean, Orlin, James B., Birren, Bruce W., Goodman, Nathan, Weissenbach, Jean, Hawkins, Trevor L., Foote, Simon, Page, David C., and Lander, Eric S.

Published
1995

49. mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice

Author

Thiem, Stefan, Pierce, Thomas P., Palmieri, Michelle, Putoczki, Tracy L., Buchert, Michael, Preaudet, Adele, Farid, Ryan O., Love, Chris, Catimel, Bruno, Lei, Zhengdeng, Rozen, Steve, Gopalakrishnan, Veena, Schaper, Fred, Hallek, Michael, Boussioutas, Alex, Tan, Patrick, Jarnicki, Andrew, and Ernst, Matthias

Subjects
Cytokines -- Health aspects -- Physiological aspects -- Research, Gastrointestinal tumors -- Risk factors -- Research -- Development and progression -- Genetic aspects, Health care industry
Abstract

Gastrointestinal cancers are frequently associated with chronic inflammation and excessive secretion of IL-6 family cytokines, which promote tumorigenesis through persistent activation of the GP130/JAK/STAT3 pathway. Although tumor progression can be prevented by genetic ablation of Stat3 in mice, this transcription factor remains a challenging therapeutic target with a paucity of clinically approved inhibitors. Here, we uncovered parallel and excessive activation of mTOR complex 1 (mTORC1) alongside STAT3 in human intestinal-type gastric cancers (IGCs). Furthermore, in a preclinical mouse model of IGC, GP130 ligand administration simultaneously activated mTORC1/S6 kinase and STAT3 signaling. We therefore investigated whether mTORC1 activation was required for inflammation-associated gastrointestinal tumorigenesis. Strikingly, the mTORC1-specific inhibitor RAD001 potently suppressed initiation and progression of both murine IGC and colitis-associated colon cancer. The therapeutic effect of RAD001 was associated with reduced tumor vascularization and cell proliferation but occurred independently of STAT3 activity. We analyzed the mechanism of GP130-mediated mTORC1 activation in cells and mice and revealed a requirement for JAK and PI3K activity but not for GP130 tyrosine phosphorylation or STAT3. Our results suggest that GP130-dependent activation of the druggable PI3K/mTORC1 pathway is required for inflammation-associated gastrointestinal tumorigenesis. These findings advocate clinical application of PI3K/mTORC1 inhibitors for the treatment of corresponding human malignancies., Introduction During the multistep process of tumor formation conditions within the tissue microenvironment can influence the fate of premalignant cells. In inflammation-associated cancers, tumor promotion is thought to be facilitated [...]

Published
2013
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50. Additional file 25 of Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammation

Author

Padmanabhan, Nisha, Kyon, Huang Kie, Boot, Arnoud, Lim, Kevin, Srivastava, Supriya, Chen, Shuwen, Wu, Zhiyuan, Lee, Hyung-O K, Mukundan, Vineeth T., Chan, Charlene, Chan, Yarn Kit, Xuewen, Ong, Pitt, Jason J., Isa, Zul Fazreen Adam, Xing, Manjie, Lee, Ming Hui, Tan, Angie Lay Keng, Ting, Shamaine Ho Wei, Luftig, Micah A., Kappei, Dennis, Kruger, Warren D., Bian, Jinsong, Ho, Ying Swan, Teh, Ming, Rozen, Steve George, and Tan, Patrick

Abstract

Additional file 25. Review history.

Published
2021
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