Search

Chemiluminescence is a fascinating phenomenon that involves the generation of light through chemical reactions. The light emission from adamantyl-phenoxy-1,2-dioxetanes can glow from minutes to hours depending on the specific substituent present on the dioxetane molecule. In order to improve the light emission properties produced by these chemiluminescent luminophores, it is necessary to induce the chemiexcitation rate to a flash mode, wherein the bulk of light is emitted instantly rather than slowly over time. We report the realization of this goal through the incorporation of spirostrain release into the decomposition of 1,2-dioxetane luminophores. DFT computational simulations provided support for the hypothesis that the spiro-cyclobutyl substituent accelerates chemiexcitation as compared to the unstrained adamantyl substituent. Spiro-linking of cyclobutane and oxetane units led to greater than 100-fold and 1000-fold emission enhancement, respectively. This accelerated chemiexcitation rate increases the detection sensitivity for known chemiluminescent probes to the highest signal-to-noise ratio documented to date. A turn-ON probe, containing a spiro-cyclobutyl unit, for detecting the enzyme β-galactosidase exhibited a limit of detection value that is 125-fold more sensitive than that for the previously described adamantyl analogue. This probe was also able to instantly detect and image β-gal activity with enhanced sensitivity in E. coli bacterial assays.

Integrating artificial intelligence (AI) with electrochemical biosensors is revolutionizing medical treatments by enhancing patient data collection and enabling the development of advanced wearable sensors for health, fitness, and environmental monitoring. Electrochemical biosensors, which detect biomarkers through electrochemical processes, are significantly more effective. The integration of artificial intelligence is adept at identifying, categorizing, characterizing, and projecting intricate data patterns. As the Internet of Things (IoT), big data, and big health technologies move from theory to practice, AI-powered biosensors offer significant opportunities for real-time disease detection and personalized healthcare. Still, they also pose challenges such as data privacy, sensor stability, and algorithmic bias. This paper highlights the critical advances in material innovation, biorecognition elements, signal transduction, data processing, and intelligent decision systems necessary for developing next-generation wearable and implantable devices. Despite existing limitations, the integration of AI into biosensor systems shows immense promise for creating future medical devices that can provide early detection and improved patient outcomes, marking a transformative step forward in healthcare technology.

Abstract Background Japanese Kawasaki disease (KD) risk scores cannot be adopted in non-Japanese patients. In North American populations a baseline coronary artery Z-score > 2 and the Son score are associated with coronary artery aneurysms (CAAs) at 4 and 8 weeks from disease onset. In European populations, the Kawanet and Kawanet-echo scores are associated with intravenous immunoglobulin resistance. This study aims to evaluate the association between KD risk scores and baseline coronary artery Z-scores with CAAs at one, two, and six months in a European population. Methods Historical cohort study of all the children diagnosed with KD in a tertiary care hospital in Milan, Italy, between 1st January 2015 and 31st May 2021. Univariate and multivariate (adjusting for age and corticosteroid therapy) logistic regression analyses were used to study the association between the risk scores, a baseline Z-score ≥ 2 and ≥ 2.5 with CAAs. Results Eighty-nine patients were diagnosed with KD at our Centre, and 12 were excluded based on the exclusion criteria. We included 77 patients, 51 (66%) males, and 26 (34%) females, with a median age at presentation of 27 months (IQR 13–46). A baseline Z-score ≥ 2 was correlated with CAAs at one and two-month follow-ups (odds ratio (OR) 10, 95% confidence interval (CI) 2–72, and OR 18, CI 3-357) but not at six-month follow-up. The Son score showed an association with one and two-month follow-up CAAs (OR 3, CI 1.3-7, and OR 3, CI 1.3-8) but not with a six-month follow-up. Conclusions Patients with a baseline Z-score ≥ 2 are at higher risk for CAAs in the long term. The Son score should be tested in larger European samples. Further studies should keep the observational periods longer than 8 weeks from KD onset.

This study presents a novel low-cost and low-power prepaid water meter system that combines tokenization and LC sensors to monitor water consumption accurately with mobile application via Bluetooth Low Energy (BLE) connectivity compared to conventional meters. Water meters play a vital role in monitoring water usage in Indonesia. Postpaid billing methods that rely on manual data recording are a source of concern due to potential inaccuracies caused by human error. This study presents the development of a prepaid water meter system that integrates LC sensors, BLE connectivity, a tokenization mechanism, and a mobile application to address this issue. The system offers a cost-effective solution by utilizing BLE + Global System for Mobile (GSM) from the user’s mobile phone. Using the design thinking methodology, the mobile application for the prepaid water meter achieved a usability testing score of 80. The load testing results for the back-end server, conducted with a sample size of 515 users, revealed a back-end latency of 1.973 milliseconds and an error rate of 8.74%. Furthermore, the LC sensors integrated into the PWM device showed an average error rate of 1.33%. The power consumption during each work cycle was measured at 129 mA and each battery is expected to last six years. Overall, with simple LC sensors, this system can precisely measure water usage.

In contrast to other common anticoagulants such as citrate and low-molecular-weight heparin (LMWH), high-molecular-weight heparin (HMWH) induces the expression of matrix metalloproteinase (MMP)-9, which is also measured as a biomarker for stroke in blood samples. Mechanistically, HMWH-stimulated T cells produce cytokines that induce monocytic MMP-9 expression. Here, the influence of further anticoagulants (Fondaparinux, Hirudin, and Alteplase) and the heparin-contaminating glycosaminoglycans (GAG) hyaluronic acid (HA), dermatan sulfate (DS), chondroitin sulfate (CS), and over-sulfated CS (OSCS) on MMP-9 was analyzed to assess its suitability as a biomarker under various conditions. Therefore, starved Jurkat T cells were stimulated with anticoagulants/contaminants. Subsequently, starved monocytic THP-1 cells were incubated with the conditioned Jurkat supernatant, and MMP-9 mRNA levels were monitored (quantitative (q)PCR). Jurkat-derived mediators secreted in response to anticoagulants/contaminants were also assessed (proteome profiler array). The supernatants of HMWH-, Hirudin-, CS-, and OSCS-treated Jurkat cells comprised combinations of activating mediators and led to a significant (in the case of OSCS, dramatic) MMP-9 induction in THP-1. HA induced MMP-9 only in high concentrations, while LMWH, Fondaparinux, Alteplase, and DS had no effect. This indicates that depending on molecular weight and charge (but independent of anticoagulant activity), anticoagulants/contaminants provoke the expression of T-cell-derived cytokines/chemokines that induce monocytic MMP-9 expression, thus potentially impairing the diagnostic validity of MMP-9.

Dementia is a progressive condition and an umbrella term used to describe a set of symptoms that affects many older adults. Older adults living with dementia often experience social stigma, which can impact their quality of life. Most people with dementia need the assistance of a caregiver in order to enhance their health. The present study seeks to explore the perspective of nurses as the primary caregivers of people living with dementia in Saudi Arabia, focusing on the challenges faced by nurses and their reactions to these challenges. A descriptive qualitative approach using semi-structured interviews with 10 nurses with experience caring for people living with dementia from 2 hospitals in Jeddah, Saudi Arabia. Using thematic analysis, 4 main themes were identified: (1) types of support, (2) challenges when caring for people living with dementia, (3) society’s views on people living with dementia, and (4) nurses’ perceptions of dementia. The nurses stated that people living with dementia do not receive sufficient support from their families. Most participants believed that public awareness about dementia is insufficient. Increased efforts to raise public awareness about dementia could include harnessing social norms around family structure and respect for elders to improve care provided to people living with dementia.

هدفت الدراسة إلى التعرف على المساندة الاجتماعية للمشرفات التربويات من حيث أبعاد المساندة (المهنية، التقنية، المادية، والنفسية)، كمدخل للتحسين من جودة الأداء التدريسي من خلال وجهة نظر معلمات العلوم في الصفوف الأولية (الأول، الثاني، والثالث) الابتدائي، ولتحقيق هذه الأهداف تم استخدام المنهج الكمي (الوصفي المسحي)، كما تم الاعتماد على الاستبانة في جمع البيانات حيث وزعت على عينة عشوائية بلغت (205) معلمة علوم من القطاعي الحكومي والخاص وتم استخلاص النتائج بنسبة 52.2% من معلمات المدارس الحكومية و 47.8% من معلمات المدارس الخاصة، وأشارت النتائج على المستوى العالي لطبيعة المساندة من المشرفة التربوية في الأبعاد (المهنية، التقنية، المادية، والنفسية) كمدخل للتحسين من جودة الأداء التدريسي، وأنه توجد فروق ذات دلالة إحصائية عند مستوى دلالة (a0.05) من وجهة نظر المعلمات حول أبعاد المساندة (المهنية، التقنية، المادية، والنفسية)؛ بناءً على نوع المدرسة (حكومي/ خاص) لصالح المدارس الحكومية، كما أنه لا توجد فروق ذات دلالة إحصائية عند مستوى دلالة (a0.05) من وجهة نظر المعلمات حول أبعاد المساندة المختلفة (المهنية، التقنية، المادية، والنفسية) بناءً على سنوات الخبرة وعدد الساعات التدريبية في مجال التنمية المهنية، وأخيرًا أوصت الدراسة بعدد من التوصيات من أبرزها زيادة الاهتمام بدور المشرفات التربويات في أبعاد المساندة الاجتماعية المختلفة (المهنية، التقنية، المادية، والنفسية) باعتبارها مداخل للتحسين من جودة الأداء التدريسي لدى معلمات العلوم وغيرهم من المعلمات في مراحل الصفوف الأولية مع تعزيز وزارة التعليم من أدائهم المهني التقني بواسطة ما تُتيح لهم من نماذج إلكترونية كالمختبرات الافتراضية، الفصول التشاركية، والشاشات التفاعلية وتدريبهم على تفعيلها بطريقة عملية وهادفة لتحقيق مخرجات مقرر العلوم للفئة المستهدفة وهم الصفوف الأولية من المرحلة الابتدائية.

Environmental conditions in hospitals facilitate the growth and spread of pathogenic bacteria on surfaces such as floors, bed rails, air ventilation units, and mobile elements. These pathogens may be eliminated with proper disinfecting processes, including the use of appropriate surface disinfectants. In this study, we aimed to evaluate of the antibacterial effects of seven surface disinfectants (HAMAYA, DAC, AJAX, Jif, Mr. MUSCLE, CLOROX, and BACTIL) against eight bacterial strains Klebsiella pneumoniae, Enterobacter aerogenes, Acinetobacter baumannii, Serratia marcescens, Escherichia coli, vancomycin-resistant Enterococcus faecalis-ATCC 51299, methicillin-resistant Staphylococcus aureus-ATCC 43300, and Pseudomonas aeruginosa-ATCC 1544, using two methods. The first was to determine the effective contact time of disinfectant against the tested bacterial strains, and the second was an assessment of the disinfection efficacy of each disinfectant on six types of contaminated surfaces with on a mixture of the eight tested bacterial strains. The results showed the efficacy of the disinfectants against the tested strains depending on the effective contact time. BACTIL disinfectant showed an efficacy of 100% against all tested strains at the end of the first minute of contact time. HAMAYA, DAC, Jif, Mr. MUSCLE, and CLOROX showed 100% efficiency at the end of the fourth, fifth, sixth, seventh, and fourteenth minutes, respectively, while AJAX disinfectant required nineteen minutes of contact time to show 100% efficacy against all tested strains.

Chitosan is known to exert antimicrobial activity without the need for any chemical modification; however, new derivatives of chitosan can be created to target multi-drug resistant bacteria. In this study, chitosan (CS) was cross-linked with sodium tripolyphosphate to form nanoparticles, which were then coated with polyacrylic acid (PAA). The SEM images revealed that the CS-PAA nanoparticles had spherical shapes with smooth surfaces and the size of the dried nanoparticles was approximately 222 nm. Biofilm formation was significantly inhibited by 0.5 mg/mL of CS-PAA. In-situ optical microscopy showed that CS-PAA nanoparticles inhibited the bacterial biofilm formation in Campylobacter jejuni, Pseudomonas aeruginosa, and Escherichia coli after a single treatment with 40 μg. Additionally, 20 µg of CS-PAA nanoparticles demonstrated antibacterial activity against the growth of C. jejuni, P. aeruginosa, and E. coli with notable inhibitory zones of 9, 12, and 13 mm, respectively (P

- Sustainable use of biomass waste to overcome energy and environmental challenges is an attractive solution. Corncob is one of the attractive biomass wastes as raw material for biocoke fuel production. This study investigates the potential of corncob biomass waste for biocoke production through comprehensive proximate, ultimate, and lignocellulosic analysis. The results show that the water content in biocoke is lower than raw corncob. The results of the moisture content analysis decreased to 7.72 % from 12.44 %, and the volatile meter and fixed carbon increased compared raw corncob. The carbon value corncob biocoke reached 45.56 % higher than several biomasses in previous research.

Food leftovers are a worldwide concern and the Food and Agriculture Organization reported about 400 billion USD worth of food is wasted yearly. In the Kingdom of Saudi Arabia, food waste is increasing; the loss is about 33.6% of the rice commodity only. To achieve sustainable development goals including zero hunger and sustainable consumption, the current investigation aimed to study the recycling possibilities of rice leftovers through the production of resistant starch (a nutraceutical active component). Proximate analysis, in vitro digestibility (rapidly, slowly, and resistant starches), and conformational techniques (SEM, FTIR, and DSC) were accomplished before and after treating heated or not samples with acetic, citric, and tartaric acids. Also, crackers were produced from rice starch and its sensory evaluations were completed. Results reported variations in starch content between the controls and acid treatments, but interestingly, amounts of protein, and fiber were not different. The highest production of resistant starch (more than 35%) was when treated with tartaric acid and heat treatment, followed by citric acid and heat treatment (32.5%), then acetic acid and heat treatment (28%). The FTIR pictograms revealed the acetylation of heat and acid-treated rice samples. The gelatinization enthalpy (ΔH) decreased from 10.51 to 7.81 J/g for control and treated rice by acetic acid without heat. Surprisingly, the panelists reported no differences in the sensory evaluations of crackers produced from treated rice with a high content of resistant starch, which considered as functional food. These findings help achieve food sustainability through commercial-scale functional food production.

Vitamin B12 (cyanocobalamin) is an essential nutrient with very low bioavailability. Compared with normal cells, tumor cells show an increased demand for vitamin B12 to support their abnormal proliferation, which is a feature that can be exploited for the tumor-specific delivery of therapeutic and/or diagnostic agents by functionalizing vitamin B12 with suitable metallodrugs and/or luminescent probes. In this context, we report on the design of fluorescent vitamin B12–metal conjugates of the type [FLUO–B12–{M}] in which cyanocobalamin is functionalized at the 5′-site of the ribose unit with a fluorophore (FLUO: rhodamine 6G), whereas the Co(III)–cyano moiety is N-coordinated to a metal-based anticancer scaffold ({M}: Pt(II) substrate bearing enantiopure phenylamino-oxime ligands derived from R- or S-limonene). Two novel fluorescent cyanocobalamin–platinum(II) derivatives and their corresponding non-fluorescent counterparts were successfully generated and fully characterized, including the evaluation of their lipophilicity and luminescent properties. Although they exhibit low antiproliferative activity (IC50 = 40–70 μM), both fluorescent vitamin B12–platinum(II) conjugates showed an enhanced capability to inhibit cell viability compared with the inactive metal precursors and the non-fluorescent vitamin B12–platinum(II) analogues, confirming the beneficial effect of functionalization with the rhodamine 6G scaffold not only for imaging purposes but also with the aim of improving their biological activity.

In this work we study how the presence of social groups affect emergency evacuations. This investigation was carried out in the context of the Social Force Model (SFM). We added an attractive force to the SFM, which accounts for the affective feelings that the members of social groups share (colleagues, friends, couples, etc.). We calibrated this force using experimental data, in order to simulate emergency evacuations. We observe that the evacuation time is consi-derably worsened when attractive feelings are taken into account. Therefore, we conclude that this kind of collective behavior should be included in pedestrian dynamics models.

Background: Despite the marked decline of schistosomiasis in Saudi Arabia in recent years, it is still reported in several regions. This study investigates the epidemiology of schistosomiasis in Saudi Arabia over seven years (2014–2020). Methodology: A retrospective study was retrieved from the annual reports of the Ministry of Health. A Geographic Information System GIS, Chi-square, and logistic regression were used to analyze the data. Results: Out of the 4,371,481 tested, 680 cases were positive for schistosomiasis, with a cumulative incidence rate of 2.155/100,000 population. This number showed significant variation over the study period (p value < 0.001). The highest number of cases detected in 2015 was almost 2-fold (OR = 1.93; 95%CI: 1.36–2.74) higher than in 2020. Both clinical forms (urinary and intestinal schistosomiasis) exist in Saudi Arabia (79.6% and 20.4% of all schistosomiasis cases, respectively). Schistosomiasis was reported in seven out of thirteen regions. Among them, Mecca has a relatively high number of cases (OR = 5.57; 95%CI: 2.49–12.47). Conversely, the Eastern Province has a low number of cases (OR = 0.09; 95%CI: 0.02–0.39) when compared to the Najran region (p value > 0.001). Regarding the distribution of schistosomiasis cases by gender and nationality, we noticed that most of the positive cases were found among males (70.6%) and expatriates (83.6%). Conclusions: The persistence of schistosomiasis and the disparity in the demographic factors underscores the imperative for intensified and integrative One Health interventions to combat this disease in Saudi Arabia.

Neuroblastoma is the most common extracranial, intrabdominal, suprarenal solid tumor of childhood. It usually presents with painless abdominal mass with or without abdominal pain. We report an unusual subtle cervical lymph nodes enlargement associated with fever and joint pain. Neuroblastoma usually starts in the adrenal glands. What is unique in our case is that the presentation is without a primary tumor. We present a case of 4-year-old female Egyptian complaining of recurrent pattern of fever and generalized joint pain, with lower neck swelling for 1-month duration. Laboratory investigations revealed a normochromic normocytic anemia and increased inflammatory markers. Immunohistochemistry staining and immunophenotyping of the cervical lymph nodes and bone marrows confirmed the diagnosis of Neuroblastoma. This case report highlights the importance of recognizing the possibility of a metastatic neuroblastoma without primary tumor in children who presented solely of lymphadenopathy.

Limbah biomassa di Indonesia umumnya dan khususnya di Aceh ketersediaannya saat cukup melimpah. Salah satu limbah biomassa yang melimpah saat ini adalah bonggol jagung sisa produk pertanian. Limbah biomassa seperti bonggol jagung dapat dimanfaatkan menjadi bahan bakar (bio-coke) yang memiliki nilai kalor tinggi dan ramah lingkungan. Penelitian ini bertujuan untuk membuat bahan bakar padat berbasis biomassa yang memiliki nilai kalor tinggi sebagai pengganti kayu bakar. Proses produksi bahan bakar dilakukan melalui beberapa perlakukan seperti pengeringan, penggilingan dan pengayakan. Selanjutnya, dimasukkan ke dalam cetakan dan kemudian ditekan hingga 22 MPa dengan pemanasan 150oC. Alat tekan yang digunakan adalah mesin press dan pemanas menggunakan heater. Hasil penelitian menunjukkan bahwa bahan bakar (bio-coke) yang diproduksi memiliki densitas tinggi 1.41 untuk ukuran 25 mm dan 1.43 untuk ukuran sampel 30 mm. Secara keseluruhan hasil produksi bahan bakar padat (bio-coke) berbasis bonggol jagung memiliki densitas yang lebih baik.

This study dealt with the relationship between the imports and the oil revenues in Iraq from 2004 to 2021 by studying and analyzing these variables. The main aims of this study are: identify the nature of the Iraqi imports and the extent of their dependence on oil revenues, explain the shortcomings in the economic policy, especially the commercial, as oil exports constitute 95% of the total Iraqi exports, analyze the growth of the Iraqi imports, as well as oil revenues and their role in the Iraqi economy and measure the impact of oil revenues on the imports. The study hypothesizes that there is a fundamental dependence on oil revenues in funding the imports in the Iraqi economy, which in turn affects the conditions of oil demand in the foreign market, and thus its import capacity corresponds to the trends of its revenues. The results show that during 2004-2021 the imports are clearly consistent with the oil revenues, as the increase or decrease in the revenues affects the imports in the same direction, especially from the consumer side. Besides, there is a financial dominance of oil revenues over the Iraqi economy as they constitute 95% of the public revenues. They are considered the main factor for financing the Iraqi federal general budget resulting in a unilateral economy. Additionally, there is a lack of a clear-cut trade policy and dominance of the consumer pattern. The Iraqi economy is unilateral in terms of export and diversified in imports. Nowadays, the Iraqi market imports most of its needs from abroad and this affected the local production and removed much of it from the circle of competition.

Background: Dose optimization of vancomycin plays a substantial role in drug pharmacokinetics because of the increased incidence of obesity worldwide. This systematic review was aimed to highlight the current dosing strategy of vancomycin among obese patients.Methods: This systematic review was in concordance with Preferred Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The literature search was carried out on various databases such as Scopus, PubMed/MEDLINE, ScienceDirect and EMBASE using Keywords and MeSH terms related to vancomycin dosing among obese patients. Google Scholar was also searched for additional articles. The English language articles published after January, 2000 were included in this study. The quality of the study was assessed using different assessment tools for cohort, and case reports.Results: A total of 1,029 records were identified. After screening, 18 studies were included for the final review. Of total, twelve studies are retrospective and remaining six are case-control studies. A total of eight studies were conducted in pediatrics while remaining studies were conducted in adult population. Most of the studies reported the dosing interval every 6–8 h. Differences in target trough concentration exist with respect to target ranges. The administration of loading dose (20–25 mg/kg) followed by maintenance dose (15–25 mg/kg) of vancomycin is recommended in adult patients to target therapeutic outcomes. Moreover, a dose of 40–60 mg/kg/day appears appropriate for pediatric patients.Conclusion: The initial dosing of vancomycin based on TBW could be better predictor of vancomycin trough concentration. However, the clinical significance is uncertain. Therefore, more studies are needed to evaluate the dosing strategy of vancomycin in overweight or obese patients.

Meat discoloration, lipid oxidation, and undesirable texture are inevitable phenomena in basa fish fillets during storage, which in turn limits their exportation as well as decreases consumer acceptability. In addition, increasing consumers’ requirements for high-quality, minimally processed, and ready-to-cook fish fillets with an extended shelf-life is a great challenge, particularly with lifestyle changes. Accordingly, this study aimed to improve the quality, lipid stability, fatty acid profile, and lipid nutritional quality indices (LNQI) of basa fish fillets during chilling storage at 4 °C for 15 days using pepsin enzyme (E, 0.1%), rosemary oil (R, 0.5%), citric acid (CA, 0.5%), and their combination (0.1% E + 0.5% R; 0.1% E + 0.5% CA; and 0.1% E + 0.5% R + 0.5% CA). Our results revealed that all treated samples exhibited a significant increase in protein content, a significant decrease in fat content, and a marked reduction in pH, total volatile base nitrogen (TVBN), thiobarbituric acid (TBA), free fatty acids, and shear force (SF) values in comparison to control ones. Moreover, significant improvements in sensory scores, color stability, fatty acid profile, LNQI, and microbial quality of all treated samples were observed. Such findings were more pronounced in samples treated with a mixture of pepsin, rosemary, and citric acid (TVBN: 2.04 vs. 6.52 mg%; TBA: 0.40 vs. 2.68 mg malonaldehyde/Kg; and SF: 8.58 vs. 19.51 Kgf). Based on the obtained results, there was an extension for the shelf life of all treated basa fish fillet samples, especially in samples treated with a mixture of pepsin, rosemary, and citric acids when compared with the control samples (˃15 days versus 10 days). Additionally, eucalyptol, camphor, isoborneol, and α-pinene are the main components of rosemary, with great antioxidant and antimicrobial activity. In conclusion, the mixture of pepsin, rosemary, and citric acid can be applied easily in the seafood industry and at the household level to provide ready-to-cook fish fillets of high quality with great health benefits.

The presence of Ti3+ in the structure of TiO2 nanotube arrays (NTs) has been shown to enhance the photoelectrochemical (PEC) water-splitting performance of these NTs, leading to improved results compared to pristine anatase TiO2 NTs. To further improve the properties related to PEC performance, we successfully produced TiO2 NTs using a two-step electrochemical anodization technique, followed by annealing at a temperature of 450 °C. Subsequently, Mo2C was decorated onto the NTs by dip coating them with precursors at varying concentrations and times. The presence of anatase TiO2 and Ti3O5 phases within the TiO2 NTs was confirmed through X-ray diffraction (XRD) analysis. The TiO2 NTs that were decorated with Mo2C demonstrated a photocurrent density of approximately 1.4 mA cm−2, a value that is approximately five times greater than the photocurrent density exhibited by the bare TiO2 NTs, which was approximately 0.21 mA cm−2. The observed increase in photocurrent density can be ascribed to the incorporation of Mo2C as a cocatalyst, which significantly enhances the photocatalytic characteristics of the TiO2 NTs. The successful deposition of Mo2C onto the TiO2 NTs was further corroborated by the characterization techniques utilized. The utilization of field emission scanning electron microscopy (FESEM) allowed for the observation of Mo2C particles on the surface of TiO2 NTs. To validate the composition and optical characteristics of the decorated NTs, X-ray photoelectron spectroscopy (XPS) and UV absorbance analysis were performed. This study introduces a potentially effective method for developing efficient photoelectrodes based on TiO2 for environmentally sustainable hydrogen production through the use of photoelectrochemical water-splitting devices. The utilization of Mo2C as a cocatalyst on TiO2 NTs presents opportunities for the advancement of effective and environmentally friendly photoelectrochemical (PEC) systems.

Impact Digital Entrepreneurship Apprentice Program (IDEA@KPT) at Ministry of Higher Education Malaysia 2021 is a comprehensive nationwide six-month program. Forty-three teams consist of 43 Academic Supervisors, 129 institutes of Higher Learning students, and 43 Micro & Small Enterprises (MSE) owners conducted by Universiti Teknologi Malaysia. The program is aimed to develop capable students in maneuvering the digital business world. Students underwent an online Business and Digital Training, with apprenticeship and formal reportings. This article aims to present the impact of IDEA@KPT activities by analyzing 43 case studies produced in the program. A pre-codification scheme that concentrates on the study goals was the method for data collection. Before the program, all the teams were informed of the required components to ensure uniformity of the report. The evidence of significant gain and impact on the MSEs businesses was drawn from the components. Other than the components, analytics hindsight, visual appeal, persuasion ability, perception on paid ads, posting timing, and synergies beyond the digital world activities were gathered, providing richer information and insights that increase business value. Such lessons are beneficial to all parties as all businesses are demanded to utilize digital platforms nowadays.

As new molecular tracers are identified to target specific receptors, tissue, and tumor types, opportunities arise for the development of both diagnostic tracers and their therapeutic counterparts, termed “theranostics.” While diagnostic tracers utilize positron emitters or gamma-emitting radionuclides, their theranostic counterparts are typically bound to beta and alpha emitters, which can deliver specific and localized radiation to targets with minimal collateral damage to uninvolved surrounding structures. This is an exciting time in molecular imaging and therapy and a step towards personalized and precise medicine in which patients who were either without treatment options or not candidates for other therapies now have expanded options, with tangible data showing improved outcomes. This manuscript explores the current state of theranostics, providing background, treatment specifics, and toxicities, and discusses future potential trends.

Background: The Canadian Triage and Acuity Scale (CTAS) is a scale that identifies the urgency of the case and helps to determine the time needed to be assessed by the physician in the emergency department (ED). However, further research is needed to identify factors that need to be taken into consideration in future CTAS to avoid misclassification of non-urgent patients at high risk who need admission and can be triaged away from the ED. The aim of the study was to evaluate the admission of non-urgent patients to decrease the burden on the ED by triaging them away from primary health care (PHC). Methods: A descriptive-analytical retrospective cohort study was performed including all patients who presented to the ED of King Abdullah Medical Center, Makkah, during a period starting on 9 May 2019 and were classified as CTAS levels 4 and 5. Data of those patients regarding CTAS levels, sex, age, ED visit, vital signs at triage time, pain score, chief complaint, and past medical history extracted from their electronic medical records were entered into the Statistical Package for Social Sciences software (SPSS), and multivariate logistic regression was used to identify predictors of admission. Results: CTAS IV and CTAS V patients accounted for 30.3% (2509/8277) of the total ED visits. The admission rate was 6.1%. Multivariate logistic regression analysis revealed that female patients were 48% less likely to be admitted than males (adjusted odds ratio "AOR": 0.52, 95% confidence interval "CI": 0.36-0.74). Patients who presented with nausea/vomiting had an almost double chance for admission (AOR: 2.03, 95% CI: 1.09-3.79). Patients with a history of hypertension (AOR: 2.39, 95% CI: 1.68-3.40), cancer patients (AOR: 3.02, 95% CI: 2.11-4.32), and patients who presented with a respiratory rate exceeding 20/minute (AOR: 4.88, 95% CI: 1.45- 16.40) were more likely to be admitted than their counterparts. Conclusion: Non-urgent visits to EDs are common practice, and a considerable percentage of patients were admitted. All CTAS V cases can be safely triaged away to the PHC; CTAS IV can be either triaged away to PHC or to the urgent care center taking into consideration whether the patient is tachypneic, hypertensive or an oncology patient. [SJEMed 2021; 2(2.000): 133-141]

Background: β-lactams remain the cornerstone of the empirical therapy to treat various bacterial infections. This systematic review aimed to analyze the data describing the dosing regimen of β-lactams.Methods: Systematic scientific and grey literature was performed in accordance with Preferred Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The studies were retrieved and screened on the basis of pre-defined exclusion and inclusion criteria. The cohort studies, randomized controlled trials (RCT) and case reports that reported the dosing schedule of β-lactams are included in this study.Results: A total of 52 studies met the inclusion criteria, of which 40 were cohort studies, 2 were case reports and 10 were RCTs. The majority of the studies (34/52) studied the pharmacokinetic (PK) parameters of a drug. A total of 20 studies proposed dosing schedule in pediatrics while 32 studies proposed dosing regimen among adults. Piperacillin (12/52) and Meropenem (11/52) were the most commonly used β-lactams used in hospitalized patients. As per available evidence, continuous infusion is considered as the most appropriate mode of administration to optimize the safety and efficacy of the treatment and improve the clinical outcomes.Conclusion: Appropriate antibiotic therapy is challenging due to pathophysiological changes among different age groups. The optimization of pharmacokinetic/pharmacodynamic parameters is useful to support alternative dosing regimens such as an increase in dosing interval, continuous infusion, and increased bolus doses.

This study aimed to assess the prevalence of xerostomia in psychotropics-medicated outpatients of the Lisbon Psychiatric Hospital Centre (CHPL). For this cross-sectional study, 60 outpatients who underwent a general psychiatry consultation signed a consent form and answered a questionnaire assessing Summated Xerostomia Inventory (SXI-PL), and sialometry was performed. Amongst the 60 subjects, 61.70% were male, and the mean age was 51.53 ± 11.15 years. Among the population, the prevalence of hyposialia was 16.7%, and that of xerostomia was 23.3%. Higher SXI-PL scores (7.60 ± 2.26) were reported in patients with normal saliva flow. The symptom that showed a higher severity of xerostomia was “My mouth feels dry” (1.78 ± 0.81).

We conducted a cross-sectional study to assess the oral health status in psychotropic-medicated outpatients of the Lisbon Psychiatric Hospital Centre (CHPL). Sixty outpatients of the General Psychiatry consultation consented to participate in this study. An oral examination and a structured questionnaire were conducted. Among the 60 subjects, 61.70% were males and the mean age was 51.53 ± 11.15 years. The prevalence of dental caries was 98.3%, and the decayed, missing, filled index (DMFT) mean score was 18.03 ± 9.39. Considering the tooth brushing frequency, 30% and 40% brushed their teeth once and twice daily, respectively.

Hajj pilgrimage is a large mass gathering global event that may facilitate the spread and emergence of various infectious diseases as well as antimicrobial resistance (AMR) in a local and global scenario. Planning and preparing for these public health issues is a challenging and complex process for the Kingdom of Saudi Arabia (KSA) health authorities. Despite multiple efforts for the prevention and treatment of infectious diseases through longtime funding in education and medical care, the prevalence of infectious disease is still high among Hajj pilgrims. The commonly observed infectious diseases during Hajj include respiratory tract infections (influenza and pneumonia), urinary tract infections and skin infections that may necessitate the use of antimicrobials. Beta-lactams are used as a first-line treatment for hospital acquired infections as well as community acquired infections due to their broad-spectrum activity. However, most of the bacterial isolates such as Staphylococcus spp., Pseudomonas spp. and E. coli are resistant to beta-lactams. Irrational use of antimicrobials, lack of infection prevention practices and suboptimal healthcare access further exacerbate the risk of spreading AMR among Hajj pilgrims. Enhanced collaboration between countries, sharing of best practices and international cooperation are crucial in addressing AMR threats among pilgrims. Consequently, robust surveillance systems for early detection and monitoring of AMR, collaboration with national as well as international healthcare agencies, effective infection prevention and control measures, public awareness and rational use of antimicrobials via antimicrobial stewardship programs are required to mitigate the risk of AMR and ensure the health and well-being of pilgrims during Hajj.

The production of sodium hypochlorite (NaOCl) from salty wastewater using an electrochemical cell has several advantages over other methods that often require hazardous chemicals and generate toxic waste, being more sustainable and environmentally friendly. However, the process of producing sodium hypochlorite using an electrochemical cell requires careful control of the operating conditions, such as the current density, flow rate, inert electrode spacing, and electrolyte concentration, to optimize the conversion efficiency and prevent electrode fouling and degradation. In this study, NaOCl was produced via a bench-scale electrochemical cell using a flowing porous graphite electrode in a continuous flow system from salty wastewater collected from the Suez Canal in Egypt. The aim of the investigation was to examine the factors that affect the concentration of NaOCl and energy consumption, such as anodic current density, salinity, inert electrode spacing, and influent feed flow rate. A lab-scale reactor with two electrodes was used to conduct the experiments. The highest NaOCl yield of 20.6% was achieved with a graphite electrode, which had high current efficiency and rigidity at a flow rate of 4.5 mL/min, a current density of 3.183 mA/cm2, an electrode space of 0.5 cm, salinity of 40,000 ppm, and a pH of 6.4. The power consumption under these conditions was 0.0137 kwh. Additionally, a statistical and least square multivariate regression technique was employed to establish a correlation for predicting the % NaOCl production. The obtained correlation had an R2 value of 98.4%. Overall, this investigation provides valuable insights into the production of NaOCl using a continuous flow system from salty wastewater, which could have potential for industrial applications in various sectors such as textiles, detergents, paper, and pulp.

This article aimed at the synthesis and molecular docking assessment of new diimine Schiff base ligand, namely 2-((E)-(2-((Z)-2-(4-chlorophenyl)-2-hydroxyvinyl)hydrazono) methyl)-6-methoxyphenol (methoxy-diim), via the condensation of 1-(4-chloro-phenyl)-2-hydrazino-ethenol compound with 2-((E)-(2-((Z)-2-(4-chlorophenyl)-2-hydroxy vinyl) hydrazono)methyl)-6-methoxyphenol in acetic acid as well as the preparation of new binuclear complexes of Co(ii), Ni(ii), Cu(ii), and Zn(ii). The following synthesized complexes were prepared in a ratio of 2:1 (metal/ligand). The 1H-NMR, UV-Vis, and FTIR spectroscopic data; molar conductivity measurements; and microanalytical, XRD, TGA/DTG, and biological studies were carried out to determine the molecular structure of these complexes. According to the spectroscopic analysis, the two central metal ions were coordinated with the diamine ligand via the nitrogen of the hydrazine and oxygen of the hydroxyl groups for the first metal ions and via the nitrogen of the hydrazine and oxygen of the phenol group for the second metal ions. Molecular docking for the free ligand was carried out against the breast cancer 3hb5-oxidoreductase and the 4o1v-protein binding kidney cancer and COVID-19 protease, and good results were obtained.

Abstract The establishment of perovskite solar cells (PSCs) in terms of their power-conversion efficiency (PCE) over silicon-based solar cells is undeniable. The state-of-art of easy device fabrications of PSCs has enabled them to rapidly gain a place in third-generation photovoltaic technology. Numerous obstacles remain to be addressed in device efficiency and stability. Low performance owing to easily degraded surface and deterioration of perovskite film quality resulting from humidity are issues that often arise. This work explored a new approach to producing high-quality perovskite films prepared under high relative humidity (RH = 40%–50%). In particular, the ubiquitous 4-tert-butylpyridine (tBp) was introduced into lead iodide (PbI2) precursor as an additive, and the films were fabricated using a two-step deposition method followed by a delay-deposition technique of methylammonium iodide (MAI). High crystallinity and controlled nucleation of MAI were needed, and this approach revealed the significance of time control to ensure high-quality films with large grain size, high crystallography, wide coverage on substrate, and precise and evenly coupled MAI molecules to PbI2 films. Compared with the two-step method without time delay, a noticeable improvement in PCE from 3.2 to 8.3% was achieved for the sample prepared with 15 s time delay. This finding was primarily due to the significant enhancement in the open-circuit voltage, short-circuit current, and fill factor of the device. This strategy can effectively improve the morphology and crystallinity of perovskite films, as well as reduce the recombination of photogenerated carriers and increase of current density of devices, thereby achieving improved photovoltaic performance.

Owing to its propensity to swell when in contact with water, expansive soil causes severe structural problems and shrinks when they dry out. Soil stabilization is a well-known method used to enhance the soil's physical and engineering properties and is commonly adopted for improving soil structures. The mechanical stabilization of different soils is evaluated by adding varying proportions of marble dust (10, 20, 30 percent) of Penjwen, Said Sadiq and Pirmam marble waste powder) to expansive soil. Shear strength and consolidation parameters, such as void ratio, compression index, and sample swelling index, were determined as basic properties. The marble dust is obtained from the cutting and grinding of real marble from the Erbil marble factory in the experimental program. The addition of marble dust decreases the swelling percentage, with an increase in the percentage of marble powder in swelling soils. It is concluded that the swelling in Bastora soil is more than that of Erbil Airport soil, based on the swelling index studies.

The COVID-19 pandemic complicates ingrained educational inequalities around the globe and foregrounds the pertaining challenges that teachers have encountered due to school closures and the shift to distance learning. This cross-border teacher education project intended to examine how academics and pre-service teachers in different geographic locales could collaboratively explore equitable learning opportunities for diverse learners through the use of critical media literacies to respond to interconnected global crises. In this six-week cross-border teacher education project, we recruited four Mandarin and English literacy teacher candidates in Hong Kong to interact with one another and one Canadian professor as part of the teacher preparation phase of a larger-scale cross-border research project that connects youth from Hong Kong and Canada in a social networking space. For the purposes of teacher professional development, the Hong Kong teacher candidates and Canadian researchers engaged in collective exploration of how instructional designs in literacy education could promote equitable learning opportunities for diverse learners. Findings show that the cross-border teacher education project supported teacher candidates’ development of pedagogical skills and espoused their agency in promoting educational equity and collective problem-solving through critical media literacies. Findings relate the teacher candidates’ shifted perspectives from focusing on students’ decontextualized language skills to nurturing critical media skills. Changing from a deficit-oriented view about what literacy learners could not do, the teacher candidates also adopted an asset-oriented view about the linguistic and cultural repertoires that diverse learners could bring to literacy classrooms.

In this work, the performance of anion exchange membrane (AEM) electrolysis is evaluated. A parametric study is conducted, focusing on the effects of various operating parameters on the AEM efficiency. The following parameters—potassium hydroxide (KOH electrolyte concentration (0.5–2.0 M), electrolyte flow rate (1–9 mL/min), and operating temperature (30–60 °C)—were varied to understand their relationship to AEM performance. The performance of the electrolysis unit is measured by its hydrogen production and energy efficiency using the AEM electrolysis unit. Based on the findings, the operating parameters greatly influence the performance of AEM electrolysis. The highest hydrogen production was achieved with the operational parameters of 2.0 M electrolyte concentration, 60 °C operating temperature, and 9 mL/min electrolyte flow at 2.38 V applied voltage. Hydrogen production of 61.13 mL/min was achieved with an energy consumption of 48.25 kW·h/kg and an energy efficiency of 69.64%.

Halitosis atau bau mulut merupakan suatu kondisi yang bisa berdampak terhadap sosial seseorang dan sekitar 25% penduduk dunia mengalami halitosis. Penyebab halitosis 87% berasal dari rongga mulut dan 13 % dari ekstra oral. Sinusitis merupakan salah satu penyebab halitosis karena pada sinusitis terjadi aliran lendir melalui nasofaring serta merupakan media bagi bakteri untuk menghasilkan Volatile Sulphur Compound (VSC). Keadaan penyakit hidung obstruktif seperti sinusitis dapat menyebabkan bernafas melalui mulut sehingga menimbulkan serostomia yang dapat meningkatkan jumlah plak pada gigi. Penelitian ini bertujuan untuk mengetahui distribusi frekuensi halitosis pada pasien sinusitis di RSUD Meuraxa Banda Aceh. Penelitian ini bersifat deskriptif cross sectional, yang dilakukan terhadap 25 pasien sinusitis yang berobat di poli THT RSUD Meuraxa Banda Aceh. Pemeriksaan halitosis dilakukan dengan Breath Checker. Metode pengambilan subjek dilakukan dengan cara total sampling. Hasil penelitian menunjukkan 96% pasien sinusitis mengalami halitosis. Pada pasien sinusitis akut, skor halitosis yang dominan adalah 1 dan 2 sedangkan pada sinusitis kronik skor halitosis yang dominan adalah 3. Hasil penelitian ini juga menunjukkan 68% pasien sinusitis memiliki tingkat kebersihan rongga mulut yang sedang dan 32% memiliki tingkat kebersihan rongga mulut yang buruk. Kesimpulan dari penelitian ini adalah 96% pasien sinusitis mengalami halitosis dan pada sinusitis kronik memiliki skor halitosis yang dominan lebih tinggi dibandingkan sinusitis akut.

The term internet of things (IoT) has gained much popularity in the last decade, which can be defined as various connected devices over the internet. IoT has rapidly spread to include all aspects of our lives. For instance, smart houses, smart cities, and variant wearable devices. IoT devices work to do their desired goals, which is to develop a person's living with his/her minimal involvement. At the same time, IoT devices have many weaknesses, which attackers exploit to affect these devices' security. Denial of Service (DoS) and Distributed Denial of Service (DDoS) are considered the most common attacks that strike IoT security. The main aim of these attacks is to make victim systems down and inaccessible for legitimate users by malicious malware. This paper's objective is to discuss and review security issues related to DoS/DDoS attacks and their countermeasures i.e. prevention based on IoT devices' layers structure.

Background and Aim: Clinical photographs have become an important entity in contemporary dental education in Saudi Arabia. The study assessed the knowledge and skills related to clinical photography among final-year undergraduate dental students in different dental schools in the Western province of Saudi Arabia. Materials and Methods: A face-to-face interview was conducted using a pretested and validated questionnaire after obtaining relevant consent from the college administration and the students. Trained and calibrated data collectors interviewed the dental students between November 2019 and February 2020. Results: The knowledge related to clinical photography was “good” only in 17.2% of the participants, and most of the students demonstrated “poor” knowledge (58.9%). Digital single lens-reflex (DSLR) camera was used by only 43.9% of the students for taking clinical photographs. The practice of taking informed consent from patients for taking and using clinical photographs was reported in 77.6% of the dental students. Conclusion: The knowledge related to dental clinical photography was not satisfactory, and students need to improve the understanding of the proper functioning of digital cameras and also the medicolegal issues related to clinical photography.

Diatom biosilica (DBs) is the cell wall of natural diatom called frustule, which is made of porous hydrogenated amorphous silica possessing periodic micro- to nanoscale features. In this study, a simple, sensitive, and label-free photoluminescence (PL) immune-detection platform based on functionalized diatom frustules was developed. Gold nanoparticles (AuNPs) deposited on poly-dopamine-coated diatom frustules via in situ deposition which considerably decreased the intrinsic blue PL intensity of diatom biosilica. Then, goat anti-rabbit immunoglobulin G (IgG) was added to functionalize diatom biosilica-poly-dopamine-AuNPs (DBs-PDA-AuNPs). PL studies revealed that the specific binding with antigen rabbit IgG increased the peak intensity of PL in comparison with the non-complimentary antigen (human IgG). The enhancement in PL intensity of DBs-PDA had a linear correlation with antigen (rabbit IgG) concentration, whose limit of detection (LOD) reached 8 × 10-6 mg/ml. Furthermore, PL detection based on DBs-PDA-AuNPs showed a high detection sensitivity with the LOD as low as 8 × 10-9 mg/ml and spread over almost eight orders of magnitude, making it suitable for the sensitive quantitative analysis of immune complex compared with traditional fluorescence immunoassay. Hence, the study proves that the AuNP-functionalized diatom frustules can serve as an effective biosensor platform for label-free PL-based immunoassay.