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1. Isatuximab, lenalidomide, dexamethasone and bortezomib in transplant-ineligible multiple myeloma: the randomized phase 3 BENEFIT trial

Author

Leleu, Xavier, Hulin, Cyrille, Lambert, Jerome, Bobin, Arthur, Perrot, Aurore, Karlin, Lionel, Roussel, Murielle, Montes, Lydia, Cherel, Brieuc, Chalopin, Thomas, Slama, Borhane, Chretien, Marie-Lorraine, Laribi, Kamel, Dingremont, Claire, Roul, Christophe, Mariette, Clara, Rigaudeau, Sophie, Calmettes, Claire, Dib, Mamoun, Tiab, Mourad, Vincent, Laure, Delaunay, Jacques, Santagostino, Alberto, Macro, Margaret, Bourgeois, Emmanuelle, Orsini-Piocelle, Frederique, Gay, Julie, Bareau, Benoit, Bigot, Noemie, Vergez, François, Lebreton, Pierre, Tabrizi, Reza, Waultier-Rascalou, Agathe, Frenzel, Laurent, Le Calloch, Ronan, Chalayer, Emilie, Braun, Thorsten, Lachenal, Florence, Corm, Selim, Kennel, Celine, Belkhir, Rakiba, Bladé, Jean-Sebastien, Joly, Bertrand, Richez-Olivier, Valentine, Gardeney, Helene, Demarquette, Helene, Robu-Cretu, Daniela, Garderet, Laurent, Newinger-Porte, Muriel, Kasmi, Amine, Royer, Bruno, Decaux, Olivier, Arnulf, Bertrand, Belhadj, Karim, Touzeau, Cyrille, Mohty, Mohamad, Manier, Salomon, Moreau, Philippe, Avet-Loiseau, Hervé, Corre, Jill, and Facon, Thierry

Published
2024
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2. CAR‐T cells derived from multiple myeloma patients at diagnosis have improved cytotoxic functions compared to those produced at relapse or following daratumumab treatment

Author

Abecassis, Audrey, Roders, Nathalie, Fayon, Maxime, Choisy, Caroline, Nelson, Elisabeth, Harel, Stephanie, Royer, Bruno, Villesuzanne, Camille, Talbot, Alexis, Garrick, David, Goodhardt, Michele, Fermand, Jean‐Paul, Burbridge, Mike, Arnulf, Bertrand, and Bories, Jean‐Christophe

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Hematology, Cancer, Rare Diseases, Clinical Research, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, CAR‐T cells, daratumumab, multiple myeloma, peripheral tcells, relapse, Genetics, Cardiovascular medicine and haematology
Abstract

Chimeric antigen receptor T cells (CAR-T) have provided promising results in multiple myeloma (MM). However, many patients still relapse, pointing toward the need of improving this therapy. Here, we analyzed peripheral blood T cells from MM patients at different stages of the disease and investigated their phenotype and capacity to generate functional CAR-T directed against CS1 or B Cell Maturation antigen. We found a decrease in naive T cells and elevated frequencies of exhaustion markers in T cells from treated MM patients. Interestingly, individuals treated with daratumumab display elevated ratios of central memory T cells. CAR-T derived from patients at relapse show reduced in vitro expansion and cytotoxic capacities in response to MM cells compared to those produced at diagnosis. Of note, CAR-T from daratumumab treated patients display intermediate defects. Reduced anti-myeloma activity of CAR T cells from treated patients was also observed in a mouse model. Our findings suggest that T cell defects in MM patients, specifically during relapse, have a major impact on their capacity to generate efficient therapeutic CAR-T. Selecting naive or central memory T cell subsets to generate therapeutic T cells could improve the CAR-T therapy for MM.

Published
2022

3. Prognosis of hyperviscosity syndrome in newly diagnosed multiple myeloma in modern-era therapy: A real-life study

Author

Debureaux, Pierre-Edouard, Harel, Stéphanie, Parquet, Nathalie, Lemiale, Virginie, Siguret, Virginie, Goubeau, Laurie, Morin, Florence, Royer, Bruno, Cuccuini, Wendy, Elessa, Dikelele, Theves, Floriane, Brignier, Anne C, Azoulay, Elie, Arnulf, Bertrand, and Talbot, Alexis

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Rare Diseases, Clinical Research, Cancer, Hematology, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Humans, Aged, Multiple Myeloma, Retrospective Studies, Prognosis, Bortezomib, Syndrome, Hematologic Diseases, HVS, myeloma, prognosis, TPE, neurological, Immunology, Medical Microbiology, Biochemistry and cell biology, Genetics
Abstract

Hyperviscosity syndrome (HVS) is a rare complication of newly diagnosed multiple myeloma (NDMM) related to high tumour burden. Studies about the prognosis of HVS in modern-era therapy for NDMM are missing. We investigated a retrospective cohort study of NDMM with HVS between 2011-2021. Thirty-nine NDMM patients with HVS were included. HVS presentation was heterogeneous, with asymptomatic, mild, and neurological forms in 23%, 59%, and 18% of cases, respectively. No thrombosis or major bleeding was observed. Therapeutic plasma exchanges were used in 92% of patients, which were effective and well tolerated. No rebound effect was observed. All patients except one had at least one CRAB criterion. Most of the patients received bortezomib and high-dose steroids (95%) associated with an immunomodulatory drug (43%) or alkylating agents (42%). HVS in NDMM patients had dismal overall survival matched to multiple myeloma patient controls (without HVS) in our center (median: 3.6 vs. 7.7 years, p=0.01), as confirmed by multivariate analysis. Early deaths (in the first two months) occurred in 21% of older patients (>65 years). HVS in NDMM patients is a rare but life-threatening complication associated with high lethality in older patients and be a potential dismal prognosis factor in the modern treatment era.

Published
2022

4. Immune thrombocytopenia and pregnancy: an exposed/nonexposed cohort study

Author

Guillet, Stéphanie, Loustau, Valentine, Boutin, Emmanuelle, Zarour, Anissa, Comont, Thibault, Souchaud-Debouverie, Odile, Costedoat Chalumeau, Nathalie, Pan-Petesch, Brigitte, Gobert, Delphine, Cheze, Stéphane, Viallard, Jean Francois, Morin, Anne-Sophie, Sauvetre, Gaetan, Cliquennois, Manuel, Royer, Bruno, Masseau, Agathe, Terriou, Louis, Fieschi, Claire, Lambotte, Olivier, Girault, Stéphane, Lioger, Bertrand, Audia, Sylvain, Sacre, Karim, Lega, Jean Christophe, Langlois, Vincent, Benachi, Alexandra, Orvain, Corentin, Devidas, Alain, Humbert, Sebastien, Gambier, Nicolas, Ruivard, Marc, Zarrouk, Virginie, Ebbo, Mikael, Willems, Lise, Segaux, Lauriane, Mahevas, Matthieu, Haddad, Bassam, Michel, Marc, Canoui-Poitrine, Florence, and Godeau, Bertrand

Published
2023
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5. Bortezomib and high-dose melphalan conditioning regimen in frontline multiple myeloma: an IFM randomized phase 3 study

Author

Roussel, Murielle, Lauwers-Cances, Valérie, Macro, Margaret, Leleu, Xavier, Royer, Bruno, Hulin, Cyrille, Karlin, Lionel, Perrot, Aurore, Touzeau, Cyrille, Chrétien, Marie-Lorraine, Rigaudeau, Sophie, Dib, Mamoun, Nicolas-Virelizier, Emmanuelle, Escoffre-Barbe, Martine, Belhadj, Karim, Mariette, Clara, Stoppa, Anne-Marie, Araujo, Carla, Doyen, Chantal, Fontan, Jean, Kolb, Brigitte, Garderet, Laurent, Brechignac, Sabine, Malfuson, Jean-Valère, Jaccard, Arnaud, Lenain, Pascal, Borel, Cécile, Hebraud, Benjamin, Benbrahim, Omar, Dorvaux, Véronique, Manier, Salomon, Augeul-Meunier, Karine, Vekemans, Marie-Christiane, Randriamalala, Edouard, Chaoui, Driss, Caers, Jo, Chaleteix, Carine, Benboubker, Lofti, Vincent, Laure, Glaisner, Sylvie, Zunic, Patricia, Slama, Borhane, Eveillard, Jean-Richard, Humbrecht-Kraut, Catherine, Morel, Véronique, Mineur, Philippe, Eisenmann, Jean-Claude, Demarquette, Hélène, Richez, Valentine, Vignon, Marguerite, Caillot, Denis, Facon, Thierry, Moreau, Philippe, Colin, Anne-Laurène, Olivier, Pascale, Wuilleme, Soraya, Avet-Loiseau, Hervé, Corre, Jill, and Attal, Michel

Published
2022
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7. Teclistamab in relapsed or refractory AL amyloidosis: a multinational retrospective case series

Author

Forgeard, Nathalie, primary, Elessa, Dikélélé, additional, Carpinteiro, Alexander, additional, Belhadj, Karim, additional, Minnema, Monique, additional, Roussel, Murielle, additional, Huart, Antoine, additional, Javaugue, Vincent, additional, Pascal, Laurent, additional, Royer, Bruno, additional, Talbot, Alexis, additional, Gounot, Romain, additional, Hegenbart, Ute, additional, Schonland, Stefan, additional, Karlin, Lionel, additional, Harel, Stéphanie, additional, Kastritis, Efstathios, additional, Bridoux, Frank, additional, Jaccard, Arnaud, additional, and Arnulf, Bertrand, additional

Published
2024
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8. Bortezomib, thalidomide, and dexamethasone with or without daratumumab for transplantation-eligible patients with newly diagnosed multiple myeloma (CASSIOPEIA): health-related quality of life outcomes of a randomised, open-label, phase 3 trial

Author

Roussel, Murielle, Moreau, Philippe, Hebraud, Benjamin, Laribi, Kamel, Jaccard, Arnaud, Dib, Mamoun, Slama, Borhane, Dorvaux, Véronique, Royer, Bruno, Frenzel, Laurent, Zweegman, Sonja, Klein, Saskia K, Broijl, Annemiek, Jie, Kon-Siong, Wang, Jianping, Vanquickelberghe, Veronique, de Boer, Carla, Kampfenkel, Tobias, Gries, Katharine S, Fastenau, John, and Sonneveld, Pieter

Published
2020
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9. The EMMY Longitudinal, Cohort Study: Real-World Data to Describe Multiple Myeloma Management and Outcomes as More Therapeutic Options Emerge

Author

Decaux, Olivier, primary, Garlantézec, Ronan, additional, Belhadj-Merzoug, Karim, additional, Macro, Margaret, additional, Frenzel, Laurent, additional, Perrot, Aurore, additional, moreau, Philippe, additional, Royer, Bruno, additional, Caillot, Denis, additional, Leleu, Xavier, additional, Mohty, Mohamad, additional, Karlin, Lionel, additional, Feugier, Pierre, additional, Rigaudeau, Sophie, additional, Fontan, Jean, additional, Sonntag, Cécile, additional, Vincent, Laure, additional, Chalopin, Thomas, additional, Avet-Loiseau, Hervé, additional, Maarouf, Zakaria, additional, Chanaz, Louni, additional, Texier, Nathalie, additional, and Hulin, Cyrille, additional

Published
2024
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10. Thiotepa, Busulfan, Cyclophosphamide: Effective but Toxic Conditioning Regimen Prior to Autologous Hematopoietic Stem Cell Transplantation in Central Nervous System Lymphoma

Author

Lebon Delphine, Debureaux Pierre-Edouard, Royer Bruno, Gruson Bérengère, Joris Magalie, Votte Patrick, Marolleau Jean-Pierre, and Morel Pierre

Subjects
autologous hematopoietic stem cell transplantation, central nervous system lymphoma, infections, conditioning, adverse events, Medicine
Abstract

In primary central nervous system lymphoma, two-year progression-free survival rates of up to 63 percent have been reported for first-line autologous stem cell transplantation after conditioning with the thiotepa busulfan cyclophosphamide regimen. However, 11 percent of the patients died due to toxicity. Besides conventional survival, progression-free survival and treatment related mortality analyses, a competing-risk analysis was applied to our cohort of twenty-four consecutive patients with primary or secondary central nervous system lymphoma who underwent autologous stem cell transplantation after thiotepa busulfan cyclophosphamide conditioning. The two-year overall survival and progression-free survival rates were 78 percent and 65 percent, respectively. The treatment-related mortality rate was 21 percent. The competing risks analysis demonstrate that age 60 or over and the infusion of less than 4.6 × 106/kg CD34+ stem cells were significant adverse prognostic factors for overall survival. Autologous stem cell transplantation with thiotepa busulfan cyclophosphamide conditioning was associated with sustained remission and survival. Nevertheless, the intensive thiotepa busulfan cyclophosphamide conditioning regimen was highly toxic, especially in older patients. Thus, our results suggest that future studies should aim at identifying the subgroup of patients who will really benefit of the procedure and/or to reduce the toxicity of future conditioning regimen.

Published
2023
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11. Pomalidomide, cyclophosphamide, and dexamethasone for relapsed multiple myeloma

Author

Garderet, Laurent, Kuhnowski, Frederique, Berge, Benoit, Roussel, Murielle, Escoffre-Barbe, Martine, Lafon, Ingrid, Facon, Thierry, Leleu, Xavier, Karlin, Lionel, Perrot, Aurore, Moreau, Philippe, Marit, Gerald, Stoppa, Anne-Marie, Royer, Bruno, Chaleteix, Carine, Tiab, Mourad, Araujo, Carla, Lenain, Pascal, Macro, Margaret, Voog, Eric, Benboubker, Lofti, Allangba, Olivier, Jourdan, Eric, Orsini-Piocelle, Frederique, Brechignac, Sabine, Eveillard, Jean-Richard, Belhadj, Karim, Wetterwald, Marc, Pegourie, Brigitte, Jaccard, Arnaud, Eisenmann, Jean-Claude, Glaisner, Sylvie, Mohty, Mohamad, Hulin, Cyrille, Loiseau, Herve Avet, Mathiot, Claire, and Attal, Michel

Published
2018
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12. Minimal residual disease negativity using deep sequencing is a major prognostic factor in multiple myeloma

Author

Perrot, Aurore, Lauwers-Cances, Valerie, Corre, Jill, Robillard, Nelly, Hulin, Cyrille, Chretien, Marie-Lorraine, Dejoie, Thomas, Maheo, Sabrina, Stoppa, Anne-Marie, Pegourie, Brigitte, Karlin, Lionel, Garderet, Laurent, Arnulf, Bertrand, Doyen, Chantal, Meuleman, Nathalie, Royer, Bruno, Eveillard, Jean-Richard, Benboubker, Lotfi, Dib, Mamoun, Decaux, Olivier, Jaccard, Arnaud, Belhadj, Karim, Brechignac, Sabine, Kolb, Brigitte, Fohrer, Cecile, Mohty, Mohamad, Macro, Margaret, Richardson, Paul G., Carlton, Victoria, Moorhead, Martin, Willis, Tom, Faham, Malek, Anderson, Kenneth C., Harousseau, Jean-Luc, Leleu, Xavier, Facon, Thierry, Moreau, Philippe, Attal, Michel, Avet-Loiseau, Hervé, and Munshi, Nikhil

Published
2018
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13. Inflammation is predictive of outcome in Waldenström macroglobulinemia treated by Bruton tyrosine kinase inhibitors: a multicentric real-life study

Author

Debureaux, Pierre-Edouard, primary, Forgeard, Nathalie, additional, Elessa, Dikelele, additional, Harel, Stéphanie, additional, Frenzel, Laurent, additional, Royer, Bruno, additional, Talbot, Alexis, additional, Choquet, Sylvain, additional, Davi, Frederic, additional, Nguyen-Khac, Florence, additional, Cuccuini, Wendy, additional, Cheminant, Morgane, additional, Bravetti, Clotilde, additional, Lazarian, Gregory, additional, Kaltenbach, Sophie, additional, Hermine, Olivier, additional, Roos-Weil, Damien, additional, Espéli, Marion, additional, Balabanian, Karl, additional, and Arnulf, Bertrand, additional

Published
2023
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14. Prognostic value of soluble ST2 in AL and TTR cardiac amyloidosis: a multicenter study

Author

Nicol, Martin, primary, Vergaro, Giuseppe, additional, Damy, Thibaud, additional, Kharoubi, Mounira, additional, Baudet, Mathilde, additional, Canuti, Elena Sofia, additional, Aimo, Alberto, additional, Castiglione, Vincenzo, additional, Emdin, Michele, additional, Royer, Bruno, additional, Harel, Stephanie, additional, Cohen-Solal, Alain, additional, Arnulf, Bertrand, additional, and Logeart, Damien, additional

Published
2023
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15. Exome sequencing identifies germline variants in DIS3 in familial multiple myeloma

Author

Pertesi, Maroulio, Vallée, Maxime, Wei, Xiaomu, Revuelta, Maria V., Galia, Perrine, Demangel, Delphine, Oliver, Javier, Foll, Matthieu, Chen, Siwei, Perrial, Emeline, Garderet, Laurent, Corre, Jill, Leleu, Xavier, Boyle, Eileen M., Decaux, Olivier, Rodon, Philippe, Kolb, Brigitte, Slama, Borhane, Mineur, Philippe, Voog, Eric, Le Bris, Catherine, Fontan, Jean, Maigre, Michel, Beaumont, Marie, Azais, Isabelle, Sobol, Hagay, Vignon, Marguerite, Royer, Bruno, Perrot, Aurore, Fuzibet, Jean-Gabriel, Dorvaux, Véronique, Anglaret, Bruno, Cony-Makhoul, Pascale, Berthou, Christian, Desquesnes, Florence, Pegourie, Brigitte, Leyvraz, Serge, Mosser, Laurent, Frenkiel, Nicole, Augeul-Meunier, Karine, Leduc, Isabelle, Leyronnas, Cécile, Voillat, Laurent, Casassus, Philippe, Mathiot, Claire, Cheron, Nathalie, Paubelle, Etienne, Moreau, Philippe, Bignon, Yves–Jean, Joly, Bertrand, Bourquard, Pascal, Caillot, Denis, Naman, Hervé, Rigaudeau, Sophie, Marit, Gérald, Macro, Margaret, Lambrecht, Isabelle, Cliquennois, Manuel, Vincent, Laure, Helias, Philippe, Avet-Loiseau, Hervé, Moreno, Victor, Reis, Rui Manuel, Varkonyi, Judit, Kruszewski, Marcin, Vangsted, Annette Juul, Jurczyszyn, Artur, Zaucha, Jan Maciej, Sainz, Juan, Krawczyk-Kulis, Malgorzata, Wątek, Marzena, Pelosini, Matteo, Iskierka-Jażdżewska, Elzbieta, Grząśko, Norbert, Martinez-Lopez, Joaquin, Jerez, Andrés, Campa, Daniele, Buda, Gabriele, Lesueur, Fabienne, Dudziński, Marek, García-Sanz, Ramón, Nagler, Arnon, Rymko, Marcin, Jamroziak, Krzysztof, Butrym, Aleksandra, Canzian, Federico, Obazee, Ofure, Nilsson, Björn, Klein, Robert J., Lipkin, Steven M., McKay, James D., and Dumontet, Charles

Published
2019
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17. Recommandations 2024 de l'Intergroupe francophone du myélome sur la prise en charge des gammapathies monoclonales de signification indéterminée.

Author

Vincent, Laure, Roussel, Murielle, Macro, Margaret, Karlin, Lionel, Vekemans, Marie-Christiane, Royer, Bruno, Kuhnowski, Frédérique, Meuleman, Nathalie, Rey, Philippe, Arnulf, Bertrand, Fermand, Jean-Paul, and Decaux, Olivier

Abstract

Copyright of Hematologie is the property of John Libbey Eurotext Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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19. Salvage therapy post pomalidomide-based regimen in relapsed/refractory myeloma

Author

Fouquet, Guillemette, Karlin, Lionel, Macro, Margaret, Caillot, Denis, Roussel, Murielle, Arnulf, Bertrand, Pegourie, Brigitte, Petillon, Marie Odile, Mathiot, Claire, Hulin, Cyrille, Kolb, Brigitte, Stoppa, Anne-Marie, Brechiniac, Sabine, Rodon, Philippe, Dib, Mamoun, Tiab, Mourad, Richez, Valentine, Araujo, Carla, Wetterwald, Marc, Garderet, Laurent, Royer, Bruno, Perrot, Aurore, Benboubker, Lotfi, Decaux, Olivier, Escoffre-Barbe, Martine, Fermand, Jean Paul, Moreau, Philippe, Avet-Loiseau, Hervé, Attal, Michel, Facon, Thierry, and Leleu, Xavier

Published
2018
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20. What Is the Benefit of Autologous Stem Cell Transplantation in Multiple Myeloma Beyond the Age of 65? Inputs from Real-World Data in the Emmy Cohort

Author

Perrot, Aurore, Decaux, Olivier, Royer, Bruno, Caillot, Denis, Belhadj Merzoug, Karim, Farge, Agathe, Frenzel, Laurent, Sonntag, Cécile, Slama, Bohrane, Bourgeois-Petit, Emmanuelle, Moreau, Philippe, Voillat, Laurent, Luycx, Odile, Benboubker, Lotfi, Pica, Gian-Matteo, Maloisel, Frederic, Eveillard, Jean-Richard, Algrin, Caroline, Schmitt, Anna, Garlantézec, Ronan, Texier, Nathalie, Germain, Raphael, Willaime, Marion, Hulin, Cyrille, Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Microenvironment and B-cells: Immunopathology,Cell Differentiation, and Cancer (MOBIDIC), Université de Rennes (UR)-Etablissement français du sang [Rennes] (EFS Bretagne)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Necker - Enfants Malades [AP-HP], Centre Hospitalier Chalon-sur-Saône William Morey, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Institut Bergonié [Bordeaux], UNICANCER, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and CHU Pessac

Subjects
Immunology, [SDV.CAN]Life Sciences [q-bio]/Cancer, Cell Biology, Hematology, Biochemistry
Abstract

International audience; Voir également : Choix du réseau wifi à l'université de Rennes 1 Première connexion Repérer le réseau eduroam, puis s'y connecter : Le réseau eduroam est basé sur une authentification 802.1x, au niveau réseau : l'authentification de l'utilisateur est demandé dès la connexion au réseau sans-fil.

Published
2022

21. Pomalidomide and dexamethasone until progression after first salvage therapy in multiple myeloma

Author

Garderet, Laurent, primary, Kuhnowski, Frederique, additional, Berge, Benoit, additional, Roussel, Murielle, additional, Devlamynck, Laure, additional, Petillon, Marie Odile, additional, Escoffre‐Barbe, Martine, additional, Lafon, Ingrid, additional, Facon, Thierry, additional, Leleu, Xavier, additional, Karlin, Lionel, additional, Perrot, Aurore, additional, Stoppa, Anne‐Marie, additional, Royer, Bruno, additional, Chaleteix, Carine, additional, Tiab, Mourad, additional, Araujo, Carla, additional, Lenain, Pascal, additional, Macro, Margaret, additional, Belhadj, Karim, additional, Ikhlef, Souhila, additional, Hulin, Cyrille, additional, Loiseau, Herve Avet, additional, Attal, Michel, additional, and Moreau, Philippe, additional

Published
2023
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23. Clinical characteristics and outcome of 318 families with familial monoclonal gammopathy: A multicenter Intergroupe Francophone du Myélome study.

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service d'hématologie, Dumontet, Charles, Demangel, Delphine, Galia, Perrine, Karlin, Lionel, Roche, Laurent, Fauvernier, Mathieu, Golfier, Camille, Laude, Marie-Charlotte, Leleu, Xavier, Rodon, Philippe, Roussel, Murielle, Azaïs, Isabelle, Doyen, Chantal, Slama, Borhane, Manier, Salomon, Decaux, Olivier, Pertesi, Maroulio, Beaumont, Marie, Caillot, Denis, Boyle, Eileen M, Cliquennois, Manuel, Cony-Makhoul, Pascale, Doncker, Anne-Violaine, Dorvaux, Véronique, Petillon, Marie Odile, Fontan, Jean, Hivert, Bénédicte, Leduc, Isabelle, Leyronnas, Cécile, Macro, Margaret, Maigre, Michel, Mariette, Clara, Mineur, Philippe, Rigaudeau, Sophie, Royer, Bruno, Vincent, Laure, Mckay, James, Perrial, Emeline, Garderet, Laurent, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service d'hématologie, Dumontet, Charles, Demangel, Delphine, Galia, Perrine, Karlin, Lionel, Roche, Laurent, Fauvernier, Mathieu, Golfier, Camille, Laude, Marie-Charlotte, Leleu, Xavier, Rodon, Philippe, Roussel, Murielle, Azaïs, Isabelle, Doyen, Chantal, Slama, Borhane, Manier, Salomon, Decaux, Olivier, Pertesi, Maroulio, Beaumont, Marie, Caillot, Denis, Boyle, Eileen M, Cliquennois, Manuel, Cony-Makhoul, Pascale, Doncker, Anne-Violaine, Dorvaux, Véronique, Petillon, Marie Odile, Fontan, Jean, Hivert, Bénédicte, Leduc, Isabelle, Leyronnas, Cécile, Macro, Margaret, Maigre, Michel, Mariette, Clara, Mineur, Philippe, Rigaudeau, Sophie, Royer, Bruno, Vincent, Laure, Mckay, James, Perrial, Emeline, and Garderet, Laurent

Abstract

Familial forms of monoclonal gammopathy, defined as multiple myeloma (MM) or Monoclonal Gammopathy of Undetermined Significance (MGUS), are relatively infrequent and most series reported in the literature describe a limited number of families. MM rarely occurs in a familial context. MGUS is observed much more commonly, which can in some cases evolve toward full-blown MM. Although recurrent cytogenetic abnormalities have been described in tumor cells of sporadic cases of MM, the pathogenesis of familial MM remains largely unexplained. In order to identify genetic factors predisposing to familial monoclonal gammopathy, the Intergroupe Francophone du Myélome identified 318 families with at least two confirmed cases of monoclonal gammopathy. There were 169 families with parent/child pairs and 164 families with cases in at least two siblings, compatible with an autosomal transmission. These familial cases were compared with sporadic cases who were matched for age at diagnosis, sex and immunoglobulin isotype, with 10 sporadic cases for each familial case. The gender distribution, age and immunoglobulin subtypes of familial cases were unremarkable in comparison to sporadic cases. With a median follow-up of 7.4 years after diagnosis, the percentage of MGUS cases having evolved to MM was 3%. The median overall survival of the 148 familial MM cases was longer than that of matched sporadic cases, with projected values of 7.6 and 16.1 years in patients older and younger than 65 years, respectively. These data suggest that familial cases of monoclonal gammopathy are similar to sporadic cases in terms of clinical presentation and carry a better prognosis.

Published
2023

24. Characteristics, outcome, and response to therapy of multirefractory chronic immune thrombocytopenia

Author

Mahévas, Matthieu, Gerfaud-Valentin, Mathieu, Moulis, Guillaume, Terriou, Louis, Audia, Sylvain, Guenin, Sophie, Le Guenno, Guillaume, Salles, Gilles, Lambotte, Olivier, Limal, Nicolas, Viallard, Jean-François, Cheze, Stephane, Tomowiak, Cecile, Royer, Bruno, Neel, Antoine, Debouverie, Odile, Hot, Arnaud, Durieu, Isabelle, Perlat, Antoinette, Cliquennois, Manuel, Deteix, Clémence, Michel, Marc, and Godeau, Bertrand

Published
2016
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25. VTD is superior to VCD prior to intensive therapy in multiple myeloma: results of the prospective IFM2013-04 trial

Author

Moreau, Philippe, Hulin, Cyrille, Macro, Margaret, Caillot, Denis, Chaleteix, Carine, Roussel, Murielle, Garderet, Laurent, Royer, Bruno, Brechignac, Sabine, Tiab, Mourad, Puyade, Mathieu, Escoffre, Martine, Stoppa, Anne-Marie, Facon, Thierry, Pegourie, Brigitte, Chaoui, Driss, Jaccard, Arnaud, Slama, Borhane, Marit, Gerald, Laribi, Karim, Godmer, Pascal, Luycx, Odile, Eisenmann, Jean-Claude, Allangba, Olivier, Dib, Mamoun, Araujo, Carla, Fontan, Jean, Belhadj, Karim, Wetterwald, Marc, Dorvaux, Véronique, Fermand, Jean-Paul, Rodon, Philippe, Kolb, Brigitte, Glaisner, Sylvie, Malfuson, Jean-Valere, Lenain, Pascal, Biron, Laetitia, Planche, Lucie, Caillon, Helene, Avet-Loiseau, Herve, Dejoie, Thomas, and Attal, Michel

Published
2016
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26. Understanding the role of hyperdiploidy in myeloma prognosis: which trisomies really matter?

Author

Chretien, Marie-Lorraine, Corre, Jill, Lauwers-Cances, Valerie, Magrangeas, Florence, Cleynen, Alice, Yon, Edwige, Hulin, Cyrille, Leleu, Xavier, Orsini-Piocelle, Frederique, Blade, Jean-Sebastien, Sohn, Claudine, Karlin, Lionel, Delbrel, Xavier, Hebraud, Benjamin, Roussel, Murielle, Marit, Gerald, Garderet, Laurent, Mohty, Mohamad, Rodon, Philippe, Voillat, Laurent, Royer, Bruno, Jaccard, Arnaud, Belhadj, Karim, Fontan, Jean, Caillot, Denis, Stoppa, Anne-Marie, Attal, Michel, Facon, Thierry, Moreau, Philippe, Minvielle, Stephane, and Avet-Loiseau, Hervé

Published
2015
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27. Clinical characteristics and outcome of 318 families with familial monoclonal gammopathy: A multicenter Intergroupe Francophone du Myélome study

Author

Dumontet, Charles, primary, Demangel, Delphine, additional, Galia, Perrine, additional, Karlin, Lionel, additional, Roche, Laurent, additional, Fauvernier, Mathieu, additional, Golfier, Camille, additional, Laude, Marie‐Charlotte, additional, Leleu, Xavier, additional, Rodon, Philippe, additional, Roussel, Murielle, additional, Azaïs, Isabelle, additional, Doyen, Chantal, additional, Slama, Borhane, additional, Manier, Salomon, additional, Decaux, Olivier, additional, Pertesi, Maroulio, additional, Beaumont, Marie, additional, Caillot, Denis, additional, Boyle, Eileen M., additional, Cliquennois, Manuel, additional, Cony‐Makhoul, Pascale, additional, Doncker, Anne‐Violaine, additional, Dorvaux, Véronique, additional, Petillon, Marie Odile, additional, Fontan, Jean, additional, Hivert, Bénédicte, additional, Leduc, Isabelle, additional, Leyronnas, Cécile, additional, Macro, Margaret, additional, Maigre, Michel, additional, Mariette, Clara, additional, Mineur, Philippe, additional, Rigaudeau, Sophie, additional, Royer, Bruno, additional, Vincent, Laure, additional, Mckay, James, additional, Perrial, Emeline, additional, and Garderet, Laurent, additional

Published
2023
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28. Pomalidomide plus low-dose dexamethasone in multiple myeloma with deletion 17p and/or translocation (4;14): IFM 2010-02 trial results

Author

Leleu, Xavier, Karlin, Lionel, Macro, Margaret, Hulin, Cyrille, Garderet, Laurent, Roussel, Murielle, Arnulf, Bertrand, Pegourie, Brigitte, Kolb, Brigitte, Stoppa, Anne Marie, Brechiniac, Sabine, Marit, Gerald, Thielemans, Beatrice, Onraed, Brigitte, Mathiot, Claire, Banos, Anne, Lacotte, Laurence, Tiab, Mourad, Dib, Mamoun, Fuzibet, Jean-Gabriel, Petillon, Marie Odile, Rodon, Philippe, Wetterwald, Marc, Royer, Bruno, Legros, Laurence, Benboubker, Lotfi, Decaux, Olivier, Escoffre-Barbe, Martine, Caillot, Denis, Fermand, Jean Paul, Moreau, Philippe, Attal, Michel, Avet-Loiseau, Herve, and Facon, Thierry

Published
2015
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29. Prognosis of hyperviscosity syndrome in newly diagnosed multiple myeloma in modern-era therapy: A real-life study

Author

Debureaux, Pierre-Edouard, primary, Harel, Stéphanie, additional, Parquet, Nathalie, additional, Lemiale, Virginie, additional, Siguret, Virginie, additional, Goubeau, Laurie, additional, Morin, Florence, additional, Royer, Bruno, additional, Cuccuini, Wendy, additional, Elessa, Dikelele, additional, Theves, Floriane, additional, Brignier, Anne C., additional, Azoulay, Elie, additional, Arnulf, Bertrand, additional, and Talbot, Alexis, additional

Published
2022
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30. Prognosis of Hyperviscosity Syndrome in Newly Diagnosed Multiple Myeloma in Modern-Era Therapy: A Real-Life Monocentric Study

Author

Debureaux, Pierre-Edouard, primary, Harel, Stephanie, additional, Parquet, Nathalie, additional, Lemiale, Virginie, additional, Siguret, Virginie, additional, Goubeau, Laurie, additional, Morin, Florence, additional, Royer, Bruno, additional, Cuccuini, Wendy, additional, Elessa, Dikelele, additional, Theves, Floriane, additional, Brignier, Anne, additional, Azoulay, Elie, additional, Arnulf, Bertrand, additional, and Talbot, Alexis, additional

Published
2022
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31. Effect of High-Cutoff Hemodialysis vs Conventional Hemodialysis on Hemodialysis Independence Among Patients With Myeloma Cast Nephropathy: A Randomized Clinical Trial

Author

Bridoux, Frank, Carron, Pierre-Louis, Pegourie, Brigitte, Alamartine, Eric, Augeul-Meunier, Karine, Karras, Alexandre, Joly, Bertrand, Peraldi, Marie-Noëlle, Arnulf, Bertrand, Vigneau, Cécile, Lamy, Thierry, Wynckel, Alain, Kolb, Brigitte, Royer, Bruno, Rabot, Nolwenn, Benboubker, Lotfi, Combe, Christian, Jaccard, Arnaud, Moulin, Bruno, Knebelmann, Bertrand, Chevret, Sylvie, and Fermand, Jean-Paul

Published
2017
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32. An appraisal of the frequency and severity of noninfectious manifestations in primary immunodeficiencies: A study of a national retrospective cohort of 1375 patients over 10 years

Author

Alligon, Mickaël, primary, Mahlaoui, Nizar, additional, Courteille, Virginie, additional, Costes, Laurence, additional, Afonso, Veronica, additional, Randrianomenjanahary, Philippe, additional, de Vergnes, Nathalie, additional, Ranohavimparany, Anja, additional, Vo, Duy, additional, Hafsa, Inès, additional, Bach, Perrine, additional, Benoit, Vincent, additional, Garcelon, Nicolas, additional, Fischer, Alain, additional, Abou-Chahla, Wadih, additional, Adoue, Daniel, additional, Aladjidi, Nathalie, additional, Armari-Alla, Corinne, additional, Barlogis, Vincent, additional, Bayart, Sophie, additional, Bertrand, Yves, additional, Blanche, Stéphane, additional, Bodet, Damien, additional, Bonnotte, Bernard, additional, Borie, Raphaël, additional, Boutard, Patrick, additional, Boutboul, David, additional, Briandet, Claire, additional, Brion, Jean-Paul, additional, Brouard, Jacques, additional, Carausu, Liana, additional, Castelle, Martin, additional, Cathebras, Pascal, additional, Catherinot, Emilie, additional, Cheikh, Nathalie, additional, Cheminant, Morgane, additional, Cohen-Beaussant, Sarah, additional, Comont, Thibault, additional, Couderc, Louis-Jean, additional, Cougoul, Pierre, additional, Couillault, Gérard, additional, Crevon, Lionel, additional, Demonchy, Elisa, additional, Deville, Anne, additional, Devoldere, Catherine, additional, Dore, Eric, additional, Dulieu, Fabienne, additional, Durieu, Isabelle, additional, Entz-Werle, Natacha, additional, Fieschi, Claire, additional, Fouyssac, Fanny, additional, Frange, Pierre, additional, Gajdos, Vincent, additional, Galicier, Lionel, additional, Gandemer, Virginie, additional, Gardembas, Martine, additional, Gaud, Catherine, additional, Grosbois, Bernard, additional, Guffroy, Aurélien, additional, Guitton, Corinne, additional, Guillerm, Gaëlle, additional, Hachulla, Eric, additional, Hamidou, Mohamed, additional, Haro, Sophie, additional, Hatchuel, Yves, additional, Hermine, Olivier, additional, Hoarau, Cyrille, additional, Hot, Arnaud, additional, Humbert, Sébastien, additional, Jaccard, Arnaud, additional, Jais, Jean-Philippe, additional, Jannier, Sarah, additional, Jacquot, Serge, additional, Jaussaud, Roland, additional, Jeandel, Pierre-Yves, additional, Jeziorski, Eric, additional, Kebaili, Kamila, additional, Korganow, Anne-Sophie, additional, Lambotte, Olivier, additional, Lanternier, Fanny, additional, Larroche, Claire, additional, Launay, David, additional, Le Moigne, Emmanuelle, additional, Le Quellec, Alain, additional, Le Moing, Vincent, additional, Lebranchu, Yvon, additional, Lecuit, Marc, additional, Lefèvre, Guillaume, additional, Lelièvre, Jean-Daniel, additional, Lemal, Richard, additional, Li-Thiao-Te, Valérie, additional, Lortholary, Olivier, additional, Luca, Luminita, additional, Mallebranche, Coralie, additional, Malphettes, Marion, additional, Marie-Cardine, Aude, additional, Martin-Silva, Nicolas, additional, Masseau, Agathe, additional, Mazingue, Françoise, additional, Merlin, Etienne, additional, Michel, Gérard, additional, Millot, Frédéric, additional, Miot, Charline, additional, Monlibert, Béatrice, additional, Monpoux, Fabrice, additional, Moshous, Despina, additional, Mouthon, Luc, additional, Münzer, Martine, additional, Navarro, Robert, additional, Neven, Bénédicte, additional, Nouar, Dalila, additional, Nove-Josserand, Raphaële, additional, Oksenhendler, Eric, additional, Ouachée-Chardin, Marie, additional, Pagnier, Anne, additional, Pasquet, Marlène, additional, Pellier, Isabelle, additional, Perel, Yves, additional, Perlat, Antoinette, additional, Piguet, Christophe, additional, Plantaz, Dominique, additional, Rivière, Sophie, additional, Roblot, Pascal, additional, Rohrlich, Pierre-Simon, additional, Royer, Bruno, additional, Salle, Valéry, additional, Sarrot-Reynauld, Françoise, additional, Servettaz, Amélie, additional, Stephan, Jean-Louis, additional, Schleinitz, Nicolas, additional, Sokol, Harry, additional, Suarez, Felipe, additional, Swiader, Laure, additional, Taque, Sophie, additional, Thomas, Caroline, additional, Tournilhac, Olivier, additional, Thumerelle, Caroline, additional, Vannier, Jean-Pierre, additional, and Viallard, Jean-François, additional

Published
2022
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33. Pomalidomide plus low-dose dexamethasone is active and well tolerated in bortezomib and lenalidomide–refractory multiple myeloma: Intergroupe Francophone du Myélome 2009-02

Author

Leleu, Xavier, Attal, Michel, Arnulf, Bertrand, Moreau, Philippe, Traulle, Catherine, Marit, Gerald, Mathiot, Claire, Petillon, Marie Odile, Macro, Margaret, Roussel, Murielle, Pegourie, Brigitte, Kolb, Brigitte, Stoppa, Anne Marie, Hennache, Bernadette, Bréchignac, Sabine, Meuleman, Nathalie, Thielemans, Beatrice, Garderet, Laurent, Royer, Bruno, Hulin, Cyrille, Benboubker, Lotfi, Decaux, Olivier, Escoffre-Barbe, Martine, Michallet, Mauricette, Caillot, Denis, Fermand, Jean Paul, Avet-Loiseau, Hervé, and Facon, Thierry

Published
2013
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34. Bortezomib and high-dose melphalan conditioning regimen in frontline multiple myeloma: an IFM randomized phase 3 study.

Author

UCL - (MGD) Service d'hématologie, UCL - SSS/IREC/MONT - Pôle Mont Godinne, Roussel, Murielle, Lauwers-Cances, Valérie, Macro, Margaret, Leleu, Xavier, Royer, Bruno, Hulin, Cyrille, Karlin, Lionel, Perrot, Aurore, Touzeau, Cyrille, Chrétien, Marie-Lorraine, Rigaudeau, Sophie, Dib, Mamoun, Nicolas-Virelizier, Emmanuelle, Escoffre-Barbe, Martine, Belhadj, Karim, Mariette, Clara, Stoppa, Anne-Marie, Araujo, Carla, Doyen, Chantal, Fontan, Jean, Kolb, Brigitte, Garderet, Laurent, Brechignac, Sabine, Malfuson, Jean-Valère, Jaccard, Arnaud, Lenain, Pascal, Borel, Cécile, Hebraud, Benjamin, Benbrahim, Omar, Dorvaux, Véronique, Manier, Salomon, Augeul-Meunier, Karine, Vekemans, Marie-Christiane, Randriamalala, Edouard, Chaoui, Driss, Caers, Jo, Chaleteix, Carine, Benboubker, Lofti, Vincent, Laure, Glaisner, Sylvie, Zunic, Patricia, Slama, Borhane, Eveillard, Jean-Richard, Humbrecht-Kraut, Catherine, Morel, Véronique, Mineur, Philippe, Eisenmann, Jean-Claude, Demarquette, Hélène, Richez, Valentine, Vignon, Marguerite, Caillot, Denis, Facon, Thierry, Moreau, Philippe, Colin, Anne-Laurène, Olivier, Pascale, Wuilleme, Soraya, Avet-Loiseau, Hervé, Corre, Jill, Attal, Michel, UCL - (MGD) Service d'hématologie, UCL - SSS/IREC/MONT - Pôle Mont Godinne, Roussel, Murielle, Lauwers-Cances, Valérie, Macro, Margaret, Leleu, Xavier, Royer, Bruno, Hulin, Cyrille, Karlin, Lionel, Perrot, Aurore, Touzeau, Cyrille, Chrétien, Marie-Lorraine, Rigaudeau, Sophie, Dib, Mamoun, Nicolas-Virelizier, Emmanuelle, Escoffre-Barbe, Martine, Belhadj, Karim, Mariette, Clara, Stoppa, Anne-Marie, Araujo, Carla, Doyen, Chantal, Fontan, Jean, Kolb, Brigitte, Garderet, Laurent, Brechignac, Sabine, Malfuson, Jean-Valère, Jaccard, Arnaud, Lenain, Pascal, Borel, Cécile, Hebraud, Benjamin, Benbrahim, Omar, Dorvaux, Véronique, Manier, Salomon, Augeul-Meunier, Karine, Vekemans, Marie-Christiane, Randriamalala, Edouard, Chaoui, Driss, Caers, Jo, Chaleteix, Carine, Benboubker, Lofti, Vincent, Laure, Glaisner, Sylvie, Zunic, Patricia, Slama, Borhane, Eveillard, Jean-Richard, Humbrecht-Kraut, Catherine, Morel, Véronique, Mineur, Philippe, Eisenmann, Jean-Claude, Demarquette, Hélène, Richez, Valentine, Vignon, Marguerite, Caillot, Denis, Facon, Thierry, Moreau, Philippe, Colin, Anne-Laurène, Olivier, Pascale, Wuilleme, Soraya, Avet-Loiseau, Hervé, Corre, Jill, and Attal, Michel

Abstract

High-dose melphalan (HDM) and transplantation are recommended for eligible patients with multiple myeloma. No other conditioning regimen has proven to be more effective and/or safer. We previously reported in a phase 2 study that bortezomib can safely and effectively be combined with HDM (Bor-HDM), with a 32% complete response (CR) rate after transplantation. These data supported a randomized phase 3 trial. Randomization was stratified according to risk and response to induction: 300 patients were enrolled, and 154 were allocated to the experimental arm (ie, arm A) with bortezomib (1 mg/m2 intravenously [IV]) on days -6, -3, +1, and +4 and melphalan (200 mg/m2 IV) on day -2. The control arm (ie, arm B) consisted of HDM alone (200 mg/m2 IV). There were no differences in stringent CR + CR rates at day 60 posttransplant (primary end point): 22.1% in arm A vs 20.5% in arm B (P = .844). There were also no differences in undetectable minimum residual disease rates: 41.3% vs 39.4% (P = .864). Median progression-free survival was 34.0 months for arm A vs 29.6 months for arm B (adjusted HR, 0.82; 95% CI, 0.61-1.13; P = .244). The estimated 3-year overall survival was 89.5% in both arms (hazard ratio, 1.28; 95% CI, 0.62-2.64; P = .374). Sixty-nine serious adverse events occurred in 18.7% of Bor-HDM-treated patients (vs 13.1% in HDM-treated patients). The proportion of grade 3/4 AEs was similar within the 2 groups (72.0% vs 73.1%), mainly (as expected) blood and gastrointestinal disorders; 4% of patients reported grade 3/4 or painful peripheral neuropathy in arm A (vs 1.5% in arm B). In this randomized phase 3 study, a conditioning regimen with Bor-HDM did not improve efficacy end points or outcomes compared with HDM alone. The original trial was registered at www.clinicaltrials.gov as #NCT02197221.

Published
2022

36. Excess mortality after treatment with fludarabine and cyclophosphamide in combination with alemtuzumab in previously untreated patients with chronic lymphocytic leukemia in a randomized phase 3 trial

Author

Lepretre, Stephane, Aurran, Therese, Mahé, Beatrice, Cazin, Bruno, Tournilhac, Olivier, Maisonneuve, Herve, Casasnovas, Olivier, Delmer, Alain, Leblond, Veronique, Royer, Bruno, Corront, Bernadette, Chevret, Sylvie, Delépine, Roselyne, Vaudaux, Sandrine, Van Den Neste, Eric, Béné, Marie Christine, Letestu, Remi, Cymbalista, Florence, and Feugier, Pierre

Published
2012
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37. Inflammatory Waldenström's macroglobulinaemia: A French monocentric retrospective study of 67 patients

Author

Elessa, Dikelele, primary, Debureaux, Pierre‐Edouard, additional, Villesuzanne, Camille, additional, Davi, Frederic, additional, Bravetti, Clotilde, additional, Harel, Stephanie, additional, Talbot, Alexis, additional, Oksenhendler, Eric, additional, Malphettes, Marion, additional, Thieblemont, Catherine, additional, Moatti, Hannah, additional, Maarek, Odile, additional, Arnulf, Bertrand, additional, and Royer, Bruno, additional

Published
2022
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41. Autoimmune and inflammatory manifestations occur frequently in patients with primary immunodeficiencies

Author

Fischer, Alain, Provot, Johan, Jais, Jean-Philippe, Alcais, Alexandre, Mahlaoui, Nizar, Adoue, Daniel, Aladjidi, Nathalie, Amoura, Zahir, Arlet, Philippe, Armari-Alla, Corinne, Bader-Meunier, Brigitte, Barlogis, Vincent, Bayart, Sophie, Beaurain, Beatrice, Bertrand, Yves, Bienvenu, Boris, Blanche, Stéphane, Bodet, Damien, Bonnotte, Bernard, Borie, Raphaël, Boutard, Patrick, Briandet, Claire, Brion, Jean-Paul, Brito, Carolina, Brouard, Jacques, Catherinot, Emilie, Chandesris, Olivia, Cohen-Beaussant, Sarah, Coignard-Biehler, Hélène, Costes, Laurence, Couderc, Louis-Jean, Couillault, Gérard, Courteille, Virginie, Curlier, Elodie, de Saint Basile, Geneviève, Demeocq, François, de Vergnes, Nathalie, Devoldere, Catherine, Deville, Anne, Donadieu, Jean, Dore, Eric, Dulieu, Fabienne, Durieu, Isabelle, Edan, Christine, Werle, Natacha Entz, Fieschi, Claire, Fouyssac, Fanny, Frange, Pierre, Gajdos, Vincent, Galicier, Lionel, Gandemer, Virginie, Gardembas, Martine, Gaud, Catherine, Grosbois, Bernard, Guillerm, Gaelle, Hachulla, Eric, Hamidou, Mohamed, Héritier, Sébastien, Hermine, Olivier, Hoarau, Cyrille, Hoen, Bruno, Hot, Arnaud, Humbert, Sébastien, Jaccard, Arnaud, Jacquot, Serge, Jaussaud, Rolland, Jeandel, Pierre-Yves, Jeziorski, Eric, Kebaili, Kamila, Korganow, Anne-Sophie, Labrune, Philippe, Lambotte, Olivier, Lanternier, Fanny, Larroche, Claire, Le Quellec, Alain, Le Moigne, Emmanuelle, Le Moing, Vincent, Lebranchu, Yvon, Lecuit, Marc, Lefevre, Guillaume, Lemal, Richard, Le Moine, Philippe, Li Thiao Te, Valérie, Lortholary, Olivier, Lutz, Patrick, Magerus-Chatinet, Aude, Malphettes, Marion, Marie-Cardine, Aude, Silva, Nicolas Martin, Masseau, Agathe, Massot, Christian, Mazingue, Françoise, Merlin, Etienne, Michel, Gérard, Millot, Frédéric, Minckes, Odile, Monlibert, Béatrice, Monpoux, Fabrice, Moshous, Despina, Mouthon, Luc, Munzer, Martine, Neven, Bénédicte, Nove-Josserand, Raphaëlle, Oksenhendler, Eric, Ouachée-Chardin, Marie, Pagnier, Anne, Pasquali, Jean-Louis, Pasquet, Marlène, Pellier, Isabelle, Perel, Yves, Perlat, Antoinette, Picard, Capucine, Piguet, Christophe, Plantaz, Dominique, Quartier, Pierre, Rieux-Laucat, Frédéric, Roblot, Pascal, Roger, Pierre-Marie, Rohrlich, Pierre-Simon, Royer, Bruno, Salle, Valéry, Sarrot-Reynauld, Françoise, Servettaz, Amélie, Stephan, Jean-Louis, Schleinitz, Nicolas, Suarez, Felipe, Swiader, Laure, Taque, Sophie, Thomas, Caroline, Tournilhac, Olivier, Thumerelle, Caroline, Vannier, Jean-Pierre, and Viallard, Jean-François

Published
2017
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42. Molecular predictors of response to decitabine in advanced chronic myelomonocytic leukemia: a phase 2 trial

Author

Braun, Thorsten, Itzykson, Raphael, Renneville, Aline, de Renzis, Benoit, Dreyfus, François, Laribi, Kamel, Bouabdallah, Krimo, Vey, Norbert, Toma, Andrea, Recher, Christian, Royer, Bruno, Joly, Bertrand, Vekhoff, Anne, Lafon, Ingrid, Sanhes, Laurence, Meurice, Guillaume, Oréar, Cédric, Preudhomme, Claude, Gardin, Claude, Ades, Lionel, Fontenay, Michaela, Fenaux, Pierre, Droin, Nathalie, and Solary, Eric

Published
2011
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43. Epidemiological landscape of young patients with multiple myeloma diagnosed before 40 years of age: the French experience

Author

Caulier, Alexis, primary, Roussel, Murielle, additional, Morel, Pierre, additional, Lombion, Naelle, additional, Branco, Benoît, additional, Galtier, Jean, additional, Hulin, Cyrille, additional, Perrot, Aurore, additional, Richez, Valentine, additional, Michaud, Anne-Victoire, additional, Touzeau, Cyrille, additional, Doyen, Chantal, additional, Mariette, Clara, additional, Caillot, Denis, additional, Harel, Stéphanie, additional, Lenain, Pascal, additional, Ivanoff, Sarah, additional, Fontan, Jean, additional, Stoppa, Anne-Marie, additional, Manier, Salomon, additional, Garderet, Laurent, additional, Leleu, Xavier, additional, Marolleau, Jean-Pierre, additional, Arnulf, Bertrand, additional, Avet-Loiseau, Hervé, additional, and Royer, Bruno, additional

Published
2021
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46. Thromboembolism and bleeding in systemic amyloidosis: a review

Author

Nicol, Martin, primary, Siguret, Virginie, additional, Vergaro, Giuseppe, additional, Aimo, Alberto, additional, Emdin, Michele, additional, Dillinger, Jean Guillaume, additional, Baudet, Mathilde, additional, Cohen‐Solal, Alain, additional, Villesuzanne, Camille, additional, Harel, Stephanie, additional, Royer, Bruno, additional, Arnulf, Bertrand, additional, and Logeart, Damien, additional

Published
2021
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47. Real-Life Survival Data after Triple-Exposure to Proteasome Inhibitors (PI), Immunomodulators (IMID) and Anti-CD38 in Multiple Myeloma Patients in the Emmy Cohort

Author

Perrot, Aurore, primary, Hulin, Cyrille, additional, Macro, Margaret, additional, Frenzel, Laurent, additional, Araujo, Carla, additional, Moreau, Philippe, additional, Royer, Bruno, additional, Belhadj, Karim, additional, Caillot, Denis, additional, Leleu, Xavier, additional, Vekhoff, Anne, additional, Schulmann, Samantha, additional, Manier, Salomon, additional, Karlin, Lionel, additional, Vincent, Laure, additional, Rigaudeau, Sophie, additional, Chaoui, Driss, additional, Garlantezec, Ronan, additional, Texier, Nathalie, additional, Willaime, Marion, additional, Boccaccio, Catherine, additional, and Decaux, Olivier, additional

Published
2021
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48. RD Vs. VRD: What Is the First-Line, Real-Life Management of Multiple Myeloma Patients Ineligible for Stem Cell Auto Transplantation in the Emmy Cohort?

Author

Decaux, Olivier, primary, Perrot, Aurore, additional, Frenzel, Laurent, additional, Royer, Bruno, additional, Araujo, Carla, additional, Belhadj, Karim, additional, Moreau, Philippe, additional, Caillot, Denis, additional, Leleu, Xavier, additional, Farge, Agathe, additional, Vekhoff, Anne, additional, Schulmann, Samantha, additional, Fontan, Jean, additional, Orsini, Frederique, additional, Sanhes, Laurence, additional, Richez, Valentine, additional, Jaccard, Arnaud, additional, Garlantezec, Ronan, additional, Texier, Nathalie, additional, Germain, Raphael, additional, Boccaccio, Catherine, additional, and Hulin, Cyrille, additional

Published
2021
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49. Phase II Study of the Combination of Pomalidomide with Dexamethasone As Maintenance Therapy after First Relapse Treatment with PCD Followed or Not By Autologous Stem Cell Transplant in Multiple Myeloma Patients

Author

Garderet, Laurent, primary, Kuhnowski, Frédérique, additional, Berge, Benoit, additional, Roussel, Murielle, additional, Escoffre-Barbe, Martine, additional, Lafon, Ingrid, additional, Facon, Thierry, additional, Leleu, Xavier, additional, Karlin, Lionel, additional, Perrot, Aurore, additional, Moreau, Philippe, additional, Marit, Gerald, additional, Stoppa, Anne-Marie, additional, Royer, Bruno, additional, Chaleteix, Carine, additional, Tiab, Mourad, additional, Araujo, Carla, additional, Lenain, Pascal, additional, Macro, Margaret, additional, Voog, Eric G., additional, Benboubker, Lotfi, additional, Allangba, Olivier Thierry, additional, Jourdan, Eric, additional, Orsini-Piocelle, Frédérique, additional, Brechignac, Sabine, additional, Eveillard, Jean-Richard, additional, Belhadj, Karim, additional, Wetterwald, Marc, additional, Pegourie, Brigitte, additional, Jaccard, Arnaud, additional, Eisenmann, Jean Claude, additional, Glaisner, Sylvie, additional, Mohty, Mohamad, additional, Hulin, Cyrille, additional, Avet Loiseau, Herve, additional, Mathiot, Claire, additional, and Attal, Michel, additional

Published
2021
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50. Impact of eculizumab treatment on paroxysmal nocturnal hemoglobinuria: a treatment versus no-treatment study

Author

Loschi, Michael, Porcher, Raphael, Barraco, Fiorenza, Terriou, Louis, Mohty, Mohamad, de Guibert, Sophie, Mahe, Beatrice, Lemal, Richard, Dumas, Pierre-Yves, Etienne, Gabriel, Jardin, Fabrice, Royer, Bruno, Bordessoule, Dominique, Rohrlich, Pierre Simon, Fornecker, Luc Mathieu, Salanoubat, Celia, Maury, Sebastien, Cahn, Jean-Yves, Vincent, Laure, Sene, Thomas, Rigaudeau, Sophie, Nguyen, Stephanie, Lepretre, Anne-Claire, Mary, Jean-Yves, Corront, Bernadette, Socie, Gerard, and de Latour, Regis Peffault

Published
2016
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