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155 results on '"Roy, Deblina"'

18. Hierarchical Climbing

Author

Rohatgi, Kopal, Shukla, Shreya, Roy, Deblina, Section editor, Shackelford, Todd K, editor, and Weekes-Shackelford, Viviana A, editor

Published
2021
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19. Heart Rate

Author

Rai, Pallavi, Roy, Deblina, Section editor, Shackelford, Todd K, editor, and Weekes-Shackelford, Viviana A, editor

Published
2021
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22. Fiction

Author

Rai, Pallavi, Roy, Deblina, Section editor, Shackelford, Todd K, editor, and Weekes-Shackelford, Viviana A, editor

Published
2021
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23. Expanding Circle, The

Author

Gupta, Shubham, Roy, Deblina, Section editor, Shackelford, Todd K, editor, and Weekes-Shackelford, Viviana A, editor

Published
2021
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27. Epinephrine

Author

Kar, Sujita Kumar, Modi, Sumit, Roy, Deblina, Section editor, Shackelford, Todd K, editor, and Weekes-Shackelford, Viviana A, editor

Published
2021
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30. Sex, Power, and Conflict

Author

Roy, Deblina, Rai, Pallavi, Kazanas, Stephanie A, Section editor, Shackelford, Todd K, editor, and Weekes-Shackelford, Viviana A, editor

Published
2021
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31. Abortion

Author

Roy, Deblina, Khongriah, Mebarisha I, Boutwell, Brian B, Section editor, Shackelford, Todd K, editor, and Weekes-Shackelford, Viviana A, editor

Published
2021
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36. Therapeutic Touch

Author

Roy, Deblina, Kar, Sujita Kumar, Arnocky, Steven, Section editor, Shackelford, Todd K, editor, and Weekes-Shackelford, Viviana A, editor

Published
2021
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43. Abortion

Author

Roy, Deblina, primary and Khongriah, Mebarisha I., additional

Published
2019
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46. A scalable and eco-friendly total synthesis of poly(ADP-ribose) polymerase inhibitor Olaparib.

Author

Chatterjee, Indranil, Roy, Deblina, and Panda, Gautam

Subjects
*POLY ADP ribose, *OLAPARIB, *HORNER-Emmons reaction, *OLEFINATION reactions, *ENZYME inhibitors, *PHOSPHONATES, *OVARIAN cancer
Abstract

A scalable total synthesis of a potent poly(ADP-ribose) polymerase (PARP) enzyme inhibitor, Olaparib (Lynparza), approved by U.S. FDA and EMA for ovarian cancer, is disclosed. The process is operationally simple, highly atom economical and environmentally benign as compared to the existing literature route of Olaparib. Herein, we report an eco-friendly synthesis of Olaparib using commercially available inexpensive starting materials, in only four steps with 51% overall yield. This synthesis comprises the key steps of generation of conjugated enolate from 2-acetylbenzoic acid to produce α-arylated product under transition metal-free conditions followed by ring construction of the final phthalazinone scaffold affording Olaparib. An alternative synthesis of another PARP inhibitor, AZD2461, using the same protocol is also reported. Highlighting this work is the phosphonate-free synthesis, as opposed to the Horner–Wadsworth–Emmons olefination reaction utilized previously which requires the synthesis of a phosphonate precursor. [ABSTRACT FROM AUTHOR]

Published
2023
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