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1,050 results on '"Rovers, Maroeska M."'

6. Predicting Personalised Absolute Treatment Effects in Individual Participant Data Meta-Analysis: An Introduction to Splines

Author

Belias, Michail, Rovers, Maroeska M., Hoogland, Jeroen, Reitsma, Johannes B., Debray, Thomas P. A., and IntHout, Joanna

Abstract

One of the main goals of an individual participant data meta-analysis (IPD-MA) of intervention studies is to investigate whether treatment effect differences are present, and how they are associated with patient characteristics. Examining treatment heterogeneity due to a continuous covariable (e.g., BMI or age) may be challenging, since there is often no prior knowledge on functional form of the conditional association between the outcome and the continuous variable. Modelling treatment effect differences whilst accounting for non-linear functional shapes may provide the opportunity to accurately make inferences whether a patient should be treated or not. To account for non-linearities the authors may estimate the functional shape of the associations and investigate potential treatment effect differences. So far, a variety of methods that account for non-linear functional shapes has been proposed. In this manuscript, the authors focus on the use of splines since they can capture both non-linear main effects and non-linear treatment-covariable interaction effects without the need to pre-specify their functional form. The goal is to explain and illustrate how to predict a conditional absolute treatment effect, as this measure is most relevant for clinical decision-making. The authors describe the various spline approaches and their application in IPD-MA using pointwise meta-analysis, multivariate meta-analysis, and generalised additive mixed effects models, and the authors provide the corresponding R-code. They also describe the results of the aforementioned spline and pooling methods using an empirical individual participant data-set, investigating the effect of antibiotics in children with acute otitis media (AOM).

Published
2022
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10. Learning Curve Analysis for Intracorporeal Robot-assisted Radical Cystectomy: Results from the EAU Robotic Urology Section Scientific Working Group

Author

Wijburg, Carl J., Hannink, Gerjon, Michels, Charlotte T.J., Weijerman, Philip C., Issa, Rami, Tay, Andrea, Decaestecker, Karel, Wiklund, Peter, Hosseini, Abolfazl, Sridhar, Ashwin, Kelly, John, d'Hondt, Frederiek, Mottrie, Alexandre, Klaver, Sjoerd, Edeling, Sebastian, Dell'Oglio, Paolo, Montorsi, Francesco, Rovers, Maroeska M., and Witjes, J. Alfred

Published
2022
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11. Robot-assisted Versus Open Radical Cystectomy in Bladder Cancer: An Economic Evaluation Alongside a Multicentre Comparative Effectiveness Study

Author

Helder, Sip, Venderbosch, Guus, Calsbeek, Hilly, Wijburg, Carl J., Witjes, J. Alfred, Onna, Ilze E.W.van, Barten, Evert J., Koldewijn, Evert L., Boormans, Joost L., Wijsman, Bart P., Nooter, Ronald I., Zwaan, Peter J., Slaa, Ed te, Meer, Saskia van der, Klaver, Sjoerd O., Fossion, Laurent M.C.L., Bos, Siebe D., Melick, Harm H.E.van, Leliveld, Anna M., Meijer, Richard P., Vis, André N., Molijn, Gerard J., Berendsen, Chris L., Oddens, Jorg R., Michels, Charlotte T.J., Hannink, Gerjon, Rovers, Maroeska M., and Grutters, Janneke P.C.

Published
2022
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13. Evidence in Neurosurgery: Perspectives

Author

Shimanskaya, Viktoria, Martens, Jill, Boogaarts, Jeroen, Westert, Gert P., Rovers, Maroeska M., Bartels, Ronald H. M. A., Bartels, Ronald H. M. A., editor, Rovers, Maroeska M., editor, and Westert, Gert P., editor

Published
2019
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14. Evidence in Neurosurgery

Author

Bartels, Ronald H. M. A., Westert, Gert P., Rovers, Maroeska M., Bartels, Ronald H. M. A., editor, Rovers, Maroeska M., editor, and Westert, Gert P., editor

Published
2019
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21. Value of Serial Multiparametric Magnetic Resonance Imaging and Magnetic Resonance Imaging–guided Biopsies in Men with Low-risk Prostate Cancer on Active Surveillance After 1 Yr Follow-up

Author

Hamoen, Esther Hendrika Johanna, Hoeks, Caroline M.A., Somford, Diederik M., van Oort, Inge M., Vergunst, Henk, Oddens, Jorg R., Smits, Geert A., Bokhorst, Leonard P., Witjes, J. Alfred, Rovers, Maroeska M., Hulsbergen-van de Kaa, Christina A., and Barentsz, Jelle O.

Published
2019
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29. Bacterial colonisation of surface and core of palatine tonsils among Tanzanian children with recurrent chronic tonsillitis and obstructive sleep apnoea who underwent (adeno)tonsillectomy.

Author

Katundu, Denis R, Chussi, Desderius, van der Gaast-de Jongh, Christa E, Rovers, Maroeska M, de Jonge, Marien I, Hannink, Gerjon, and van Heerbeek, Niels

Subjects
TONSIL microbiology, HOST-bacteria relationships, TONSILLITIS, SLEEP apnea syndromes, TONSILLECTOMY, DESCRIPTIVE statistics, PALATE, DATA analysis, DATA analysis software, CHILDREN
Abstract

Objective: Acute and chronic tonsillitis are frequently treated with antibiotics. This study aimed to understand the presence of pathogenic micro-organisms on the surface and core of chronically infected tonsils among Tanzanian children. Methods: The study enrolled children undergoing adenotonsillectomy. Surface and core tonsillar swabs were taken. Quantitative polymerase chain reaction was performed for Streptococcus pneumoniae , Haemophilus influenzae , Moraxella catarrhalis , Staphylococcus aureus , Neisseria meningitidis and Pseudomonas aeruginosa. Results: Surface and core combined, isolated N meningitidis (86.1 per cent) was found the most, followed by H influenzae (74.9 per cent), S pneumoniae (42.6 per cent) and S aureus (28.7 per cent). M catarrhalis and P aeruginosa were only found in a few patients, 5.6 per cent and 0.8 per cent respectively. Conclusion: Colonisation of the tonsillar surface and core has been found. Potentially pathogenic micro-organisms are likely to be missed based on a throat swab. Hence, the practice of surface tonsillar swabbing may be misleading or insufficient. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Study protocol for a multicenter randomised controlled trial on the (cost)effectiveness of biopsy combined with same-session MR-guided LITT versus biopsy alone in patients with primary irresectable glioblastoma (EMITT trial)

Author

Neurochirurgen, Cancer, Neurochirurgie, Brain, Neutel, Céline L.G., Viozzi, Ilaria, Overduin, Christiaan G., Rijpma, Anne, Grutters, Janneke P.C., Hannink, Gerjon, van Eijsden, Pieter, Robe, Pierre A., Rovers, Maroeska M., ter Laan, Mark, Neurochirurgen, Cancer, Neurochirurgie, Brain, Neutel, Céline L.G., Viozzi, Ilaria, Overduin, Christiaan G., Rijpma, Anne, Grutters, Janneke P.C., Hannink, Gerjon, van Eijsden, Pieter, Robe, Pierre A., Rovers, Maroeska M., and ter Laan, Mark

Published
2023

33. Antibiotics for acute otitis media in children

Author

HAG Onderzoek, Child Health, Infection & Immunity, Venekamp, Roderick P, Sanders, Sharon L, Glasziou, Paul P, Rovers, Maroeska M, HAG Onderzoek, Child Health, Infection & Immunity, Venekamp, Roderick P, Sanders, Sharon L, Glasziou, Paul P, and Rovers, Maroeska M

Published
2023

34. Ventilation tubes (grommets) for otitis media with effusion (OME) in children

Author

HAG Onderzoek, Child Health, Infection & Immunity, MacKeith, Samuel, Mulvaney, Caroline A, Galbraith, Kevin, Webster, Katie E, Connolly, Rachel, Paing, Aye, Marom, Tal, Daniel, Mat, Venekamp, Roderick P, Rovers, Maroeska M, Schilder, Anne Gm, HAG Onderzoek, Child Health, Infection & Immunity, MacKeith, Samuel, Mulvaney, Caroline A, Galbraith, Kevin, Webster, Katie E, Connolly, Rachel, Paing, Aye, Marom, Tal, Daniel, Mat, Venekamp, Roderick P, Rovers, Maroeska M, and Schilder, Anne Gm

Published
2023

35. Prognosis and prediction of antibiotic benefit in adults with clinically diagnosed acute rhinosinusitis: an individual participant data meta-analysis

Author

Epi Methoden Team 4, Epi Methoden Team 1, Epi Methoden Team 3, Infection & Immunity, Epi Methoden, Cancer, JC onderzoeksprogramma Methodologie, Circulatory Health, HAG Onderzoek, Child Health, Hoogland, Jeroen, Takada, Toshihiko, van Smeden, Maarten, Rovers, Maroeska M, de Sutter, An I, Merenstein, Daniel, Kaiser, Laurent, Liira, Helena, Little, Paul, Bucher, Heiner C, Moons, Karel G M, Reitsma, Johannes B, Venekamp, Roderick P, Epi Methoden Team 4, Epi Methoden Team 1, Epi Methoden Team 3, Infection & Immunity, Epi Methoden, Cancer, JC onderzoeksprogramma Methodologie, Circulatory Health, HAG Onderzoek, Child Health, Hoogland, Jeroen, Takada, Toshihiko, van Smeden, Maarten, Rovers, Maroeska M, de Sutter, An I, Merenstein, Daniel, Kaiser, Laurent, Liira, Helena, Little, Paul, Bucher, Heiner C, Moons, Karel G M, Reitsma, Johannes B, and Venekamp, Roderick P

Published
2023

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