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49 results on '"Rovere, Patrizia"'

8. Subclinical myocardial dysfunction in patients recovered from COVID‐19

Author

Italia, Leonardo, primary, Ingallina, Giacomo, additional, Napolano, Antonio, additional, Boccellino, Antonio, additional, Belli, Martina, additional, Cannata, Francesco, additional, Rolando, Marco, additional, Ancona, Francesco, additional, Melillo, Francesco, additional, Stella, Stefano, additional, Ripa, Marco, additional, Scarpellini, Paolo, additional, Tresoldi, Moreno, additional, Ortalda, Alessandro, additional, Righetti, Beatrice, additional, De Cobelli, Francesco, additional, Esposito, Antonio, additional, Ciceri, Fabio, additional, Castagna, Antonella, additional, Rovere, Patrizia Querini, additional, Fragasso, Gabriele, additional, and Agricola, Eustachio, additional

Published
2021
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10. QTc interval prolongation, inflammation, and mortality in patients with COVID-19

Author

Gulletta, Simone, primary, Della Bella, Paolo, additional, Pannone, Luigi, additional, Falasconi, Giulio, additional, Cianfanelli, Lorenzo, additional, Altizio, Savino, additional, Cinel, Elena, additional, Da Prat, Valentina, additional, Napolano, Antonio, additional, D’Angelo, Giuseppe, additional, Brugliera, Luigia, additional, Agricola, Eustachio, additional, Landoni, Giovanni, additional, Tresoldi, Moreno, additional, Rovere, Patrizia Querini, additional, Ciceri, Fabio, additional, Zangrillo, Alberto, additional, and Vergara, Pasquale, additional

Published
2021
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28. Dendritic cell presentation of antigens from apoptotic cells in a proinflammatory context: Role of opsonizing anti-?2-glycoprotein I antibodies

Author

Rovere, Patrizia, primary, Grazia Sabbadini, Maria, additional, Vallinoto, Cristina, additional, Fascio, Umberto, additional, Rescigno, Maria, additional, Crosti, Mariacristina, additional, Ricciardi-Castagnoli, Paola, additional, Balestrieri, Genesio, additional, Tincani, Angela, additional, and Manfredi, Angelo A., additional

Published
1999
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44. In vivoadministration of GM‐CSF promotes the clearance of apoptotic cells: effects on monocytes and polymorphonuclear leukocytes

Author

Galati, Giacomo, Rovere, Patrizia, Citterio, Giovanni, Bondanza, Attilio, Scaglietti, Ugo, Bucci, Eraldo, Heltai, Silvia, Fascio, Umberto, Rugarli, Claudio, and Manfredi, Angelo A.

Abstract

The clearance of apoptotic cells is crucial to avoid chronic inflammation and autoimmunity. Little is known about the factors that regulate it in vivo.We show that granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) administration to carcinoma patients confers to their leukocytes a significantly higher ability to phagocytose apoptotic cells than before (P< 0.005). GM‐CSF increased the concentration of monocytes and polymorphonuclear leukocytes in the peripheral blood and activated circulating polymorphonuclear leukocytes. Both effects abated early after treatment, whereas phagocytosis of apoptotic cells was still significantly higher after 18 days compared with basal values (P< 0.005 and P< 0.025 for monocytes and polymorphonuclear leukocytes, respectively). On in vitrophagocytosis of apoptotic cells monocytes, but not polymorphonuclear leukocytes, up‐regulated MHC class II membrane expression. These findings are consistent with the possibility that GM‐CSF endows both scavenger and antigen‐presenting leukocytes with the ability to internalize apoptotic tumor cells. J. Leukoc. Biol.67: 174–182; 2000.

Published
2000
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45. Dendritic cell presentation of antigens from apoptotic cells in a proinflammatory context: Role of opsonizing anti–β<INF>2</INF>-glycoprotein I antibodies

Author

Rovere, Patrizia, Sabbadini, Maria Grazia, Vallinoto, Cristina, Fascio, Umberto, Rescigno, Maria, Crosti, Mariacristina, Ricciardi-Castagnoli, Paola, Balestrieri, Genesio, Tincani, Angela, and Manfredi, Angelo A.

Abstract

To verify whether opsonization of apoptotic cells skews the outcome of apoptotic cell antigen presentation by dendritic cells (DCs). RMA cells, which were engineered with a mutant ovalbumin (OVA) protein and were devoid of the leader secretory sequence (OVA-RMA), underwent ultraviolet irradiation to induce apoptosis. Binding of anti–β2-glycoprotein I antibodies (anti-β2GPI) and phagocytosis of apoptotic cells were assessed by flow cytometry and confocal microscopy. Presentation of processing antigens and major histocompatibility complex (MHC) class II–restricted or MHC class I–restricted antigens was assessed using OVA-specific T cell hybridomas. Anti-β2GPI facilitated presentation of epitopes from internalized apoptotic cells to MHC class II–restricted, but not to class I–restricted, T lymphocytes. DCs challenged with supernatants of apoptotic cells did not activate OVA-specific T cells, making it unlikely that anti-β2GPI complexed with antigen released from dying cells plays a role in antigen presentation. DCs challenged with low numbers of anti-β2GPI–opsonized apoptotic cells secreted interleukin-1β (IL-1β), tumor necrosis factor α, and IL-10 in an autocrine/paracrine manner. Opsonization influences the outcome of the disposal of low numbers of apoptotic cells by DCs. This implies that soluble factors bound to apoptotic cells modulate their immunogenicity.

Published
1999
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46. Mycobacterium tuberculosis exploits the CD95/CD95 ligand system of γ δ T cells to cause apoptosis

Author

Manfredi, Angelo A., Heltai, Silvia, Rovere, Patrizia, Sciorati, Clara, Paolucci, Clara, Galati, Giacomo, Rugarli, Claudio, Vaiani, Roberto, Clementi, Emilio, and Ferrarini, Marina

Abstract

Vγ9/Vδ2+ T cells specifically recognize Mycobacterium tuberculosis in vitro and are precociously recruited in early mycobacterial lesions. Even if γ δ T cells are only fortuitously detected in granulomas or bronchoalveolar lavages of patients with active pulmonary tuberculosis, a role in shaping the mature α β T cell response against M. tuberculosis is substantiated. Here we provide a molecular explanation for this paradox: the engagement of the γ δ TCR by mycobacterial antigens induced the expression of CD95 ligand (CD95L) by chronically activated CD95+ /CD95L− γ δ T lymphocytes. The receptor was functional, as CD95/CD95L interaction triggered the bystander death of CD95+ cells by apoptosis. Cell death was abolished by CD95-blocking antibodies. The transient accumulation at the site of infection of CD95L+ γ δ lymphocytes, capable of interacting with CD95+ leukocytes attracted by the response towards the pathogen, may determine the characteristics of the ensuing granulomatous disease.

Published
1998
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47. QTc interval prolongation, inflammation, and mortality in patients with COVID-19

Author

Paolo Della Bella, Alberto Zangrillo, Luigi Pannone, Simone Gulletta, Valentina Da Prat, Giulio Falasconi, Giuseppe D'Angelo, Antonio Napolano, Elena Cinel, Fabio Ciceri, Patrizia Rovere, Luigia Brugliera, Lorenzo Cianfanelli, Eustachio Agricola, Giovanni Landoni, Moreno Tresoldi, Pasquale Vergara, Savino Altizio, Gulletta, Simone, Della Bella, Paolo, Pannone, Luigi, Falasconi, Giulio, Cianfanelli, Lorenzo, Altizio, Savino, Cinel, Elena, Da Prat, Valentina, Napolano, Antonio, D'Angelo, Giuseppe, Brugliera, Luigia, Agricola, Eustachio, Landoni, Giovanni, Tresoldi, Moreno, Rovere, Patrizia Querini, Ciceri, Fabio, Zangrillo, Alberto, and Vergara, Pasquale

Subjects
Male, QT interval, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Multivariate analysis, Coronavirus disease 2019 (COVID-19), Inflammation, Systemic inflammation, Article, Electrocardiography, QTc, Physiology (medical), White blood cell, Internal medicine, medicine, Humans, In patient, cardiovascular diseases, business.industry, SARS-CoV-2, COVID-19, Hydroxychloroquine, Long QT Syndrome, medicine.anatomical_structure, cardiovascular system, Cardiology, medicine.symptom, Cardiology and Cardiovascular Medicine, business, circulatory and respiratory physiology, medicine.drug
Abstract

Purpose Systemic inflammation has been associated with corrected QT (QTc) interval prolongation. The role of inflammation on QTc prolongation in COVID-19 patients was investigated. Methods Patients with a laboratory-confirmed SARS-CoV-2 infection admitted to IRCCS San Raffaele Scientific Institute (Milan, Italy) between March 14, 2020, and March 30, 2020 were included. QTc-I was defined as the QTc interval by Bazett formula in the first ECG performed during the hospitalization, before any new drug treatment; QTc-II was the QTc in the ECG performed after the initiation of hydroxychloroquine drug treatment. Results QTc-I was long in 45 patients (45%) and normal in 55 patients (55%). Patients with long QTc-I were older and more frequently males. C-Reactive protein (CRP) and white blood cell (WBC) count at hospitalization were higher in patients with long QTc-I and long QTc-II. QTc-I was significantly correlated with CRP levels at hospitalization. After a median follow-up of 83 days, 14 patients (14%) died. There were no deaths attributed to ventricular arrhythmias. Patients with long QTc-I and long QTc-II had a shorter survival, compared with normal QTc-I and QTc-II patients, respectively. In Cox multivariate analysis, independent predictors of mortality were age (HR = 1.1, CI 95% 1.04–1.18, p = 0.002) and CRP at ECG II (HR 1.1, CI 95% 1.0–1.1, p = 0.02). Conclusions QTc at hospitalization is a simple risk marker of mortality risk in COVID-19 patients and reflects the myocardial inflammatory status.

Published
2021

48. Covid-19 and the role of smoking. The protocol of the multicentric prospective study COSMO-IT (COvid19 and SMOking in ITaly)

Author

Cattaruzza, M. S., Gorini, G., Bosetti, C., Boffi, R., Lugo, A., Veronese, C., Carreras, G., Santucci, C., Stival, C., Pacifici, R., Zaga, V., Gallus, S., Giulietti, F., Sarzani, R., Spannella, F., Del Donno, M., Tartaglione, S., Marrazzo, G., Pelaia, G., D'Agosto, V., Berti, A., Voller, F., Cardellicchio, S., Cresci, C., Foschino Barbaro, M. P., De Palma, R., Negrini, S., Sicbaldi, V., Serafini, A., Bisconti, M., Refolo, L., Landoni, G., Rovere, P., Veronesi, G., Faverio, P., Garavello, W., Pesci, A., Giacobbe, R., Martucci, P., Parrella, R., Scarano, F., Aiello, M., Chetta, A., Franco, C., Mangia, A., Carrozzi, L., Maggi, F., Monzani, F., Pistelli, F., Russo, P., Sanna, A., Barreca, F. M., Conti, V., Rossi, E., Ruli, M., Ruli, S., Varzaneh, S. E., Principe, R., Guerrini, S., Sebastiani, A., Galluccio, G., Pezzuto, A., Ricci, A., Casali, E., Mastroianni, C., Pirina, P., Polo, F., Beatrice, F., Romagnoli, M., Baraldo, M., Cojutti, P. G., Graziano, E., Pecori, D., Tascini, C., Tinghino, B., Cattaruzza, Maria Sofia, Gorini, Giuseppe, Bosetti, Cristina, Boffi, Roberto, Lugo, Alessandra, Veronese, Chiara, Carreras, Giulia, Santucci, Claudia, Stival, Chiara, Pacifici, Roberta, Zagà, Vincenzo, Gallus, Silvano, Giulietti, Federico, Sarzani, Riccardo, Spannella, Francesco, Del Donno, Mario, Tartaglione, Stefania, Marrazzo, Giuseppina, Pelaia, Girolamo, D'Agosto, Vincenzo, Berti, Alice, Voller, Fabio, Cardellicchio, Salvatore, Cresci, Chiara, Foschino Barbaro, Maria Pia, De Palma, Raffaele, Negrini, Simone, Sicbaldi, Vera, Serafini, Antonella, Bisconti, Mario, Refolo, Leonida, Landoni, Giovanni, Rovere, Patrizia, Veronesi, Giulia, Faverio, Paola, Garavello, Werner, Pesci, Alberto, Giacobbe, Raffaella, Martucci, Paola, Parrella, Roberto, Scarano, Francesco, Aiello, Marina, Chetta, Alfredo, Franco, Cosimo, Mangia, Angelo, Carrozzi, Laura, Maggi, Fabrizio, Monzani, Fabio, Pistelli, Francesco, Russo, Patrizia, Sanna, Antonio, Barreca, Filippo Maria, Conti, Valentina, Rossi, Enrico, Ruli, Mei, Ruli, Silvana, Eslami Varzaneh, Shokoofe, Principe, Rosastella, Guerrini, Simone, Sebastiani, Alfredo, Galluccio, Giovanni, Pezzuto, Aldo, Ricci, Alberto, Casali, Elena, Mastroianni, Claudio, Pirina, Pietro, Polo, Francesca, Beatrice, Fabio, Romagnoli, Micaela, Baraldo, Massimo, Cojutti, Pier Giorgio, Tascini, Carlo, Pecori, Davide, Graziano, Elena, Tinghino, Biagio, Cattaruzza, M, Gorini, G, Bosetti, C, Boffi, R, Lugo, A, Veronese, C, Carreras, G, Santucci, C, Stival, C, Pacifici, R, Zaga, V, Gallus, S, Giulietti, F, Sarzani, R, Spannella, F, Del Donno, M, Tartaglione, S, Marrazzo, G, Pelaia, G, D'Agosto, V, Berti, A, Voller, F, Cardellicchio, S, Cresci, C, Foschino Barbaro, M, De Palma, R, Negrini, S, Sicbaldi, V, Serafini, A, Bisconti, M, Refolo, L, Landoni, G, Rovere, P, Veronesi, G, Faverio, P, Garavello, W, Pesci, A, Giacobbe, R, Martucci, P, Parrella, R, Scarano, F, Aiello, M, Chetta, A, Franco, C, Mangia, A, Carrozzi, L, Maggi Monzani, F, Pistelli, F, Russo, P, Sanna, A, Barreca, F, Conti, V, Rossi, E, Ruli, M, Ruli, S, Varzaneh, S, Principe, R, Guerrini, S, Sebastiani, A, Galluccio, G, Pezzuto, A, Ricci, A, Casali, E, Mastroianni, C, Pirina, P, Polo, F, Beatrice, F, Romagnoli, M, Baraldo, M, Cojutti, P, Graziano, E, Pecori, D, Tascini, C, and Tinghino, B

Subjects
Male, Prognosi, Pneumonia, Viral, Lifestyle habit, COVID-19, Lifestyle habits, Prognosis, Risk factors, SARS-COV-2, Smoking, Tobacco, tobacco, smoking, Follow-Up Studie, Betacoronavirus, lifstyle habits, prognosis, tobacco, risk factors, Prevalence, Tobacco Smoking, Humans, risk factors, Viral, Prospective Studies, Life Style, Pandemics, lifestyle habits, Betacoronaviru, Pandemic, Coronavirus Infection, SARS-CoV-2, Pneumonia, Coronavirus Infections, Female, Follow-Up Studies, Italy, covid-19, sars-cov-2, Original Investigations / Commentaries, Prospective Studie, Risk factor, Human
Abstract

The emergency caused by Covid-19 pandemic raised interest in studying lifestyles and comorbidities as important determinants of poor Covid-19 prognosis. Data on tobacco smoking, alcohol consumption and obesity are still limited, while no data are available on the role of e-cigarettes and heated tobacco products (HTP). To clarify the role of tobacco smoking and other lifestyle habits on COVID-19 severity and progression, we designed a longitudinal observational study titled COvid19 and SMOking in ITaly (COSMO-IT). About 30 Italian hospitals in North, Centre and South of Italy joined the study. Its main aims are: 1) to quantify the role of tobacco smoking and smoking cessation on the severity and progression of COVID-19 in hospitalized patients; 2) to compare smoking prevalence and severity of the disease in relation to smoking in hospitalized COVID-19 patients versus patients treated at home; 3) to quantify the association between other lifestyle factors, such as e-cigarette and HTP use, alcohol and obesity and the risk of unfavourable COVID-19 outcomes. Socio-demographic, lifestyle and medical history information will be gathered for around 3000 hospitalized and 700-1000 home-isolated, laboratory-confirmed, COVID-19 patients. Given the current absence of a vaccine against SARS-COV-2 and the lack of a specific treatment for -COVID-19, prevention strategies are of extreme importance. This project, designed to highly contribute to the international scientific debate on the role of avoidable lifestyle habits on COVID-19 severity, will provide valuable epidemiological data in order to support important recommendations to prevent COVID-19 incidence, progression and mortality.

Published
2020

49. Covid-19 and the role of smoking: the protocol of the multicentric prospective study COSMO-IT (COvid19 and SMOking in ITaly).

Author

Cattaruzza MS, Gorini G, Bosetti C, Boffi R, Lugo A, Veronese C, Carreras G, Santucci C, Stival C, Pacifici R, Zagà V, Gallus S, Giulietti F, Sarzani R, Spannella F, Del Donno M, Tartaglione S, Marrazzo G, Pelaia G, D'Agosto V, Berti A, Voller F, Cardellicchio S, Cresci C, Foschino Barbaro MP, De Palma R, Negrini S, Sicbaldi V, Serafini A, Bisconti M, Refolo L, Landoni G, Rovere P, Veronesi G, Faverio P, Garavello W, Pesci A, Giacobbe R, Martucci P, Parrella R, Scarano F, Aiello M, Chetta A, Franco C, Mangia A, Carrozzi L, Maggi F, Monzani F, Pistelli F, Russo P, Sanna A, Barreca FM, Conti V, Rossi E, Ruli M, Ruli S, Eslami Varzaneh S, Principe R, Guerrini S, Sebastiani A, Galluccio G, Pezzuto A, Ricci A, Casali E, Mastroianni C, Pirina P, Polo F, Beatrice F, Romagnoli M, Baraldo M, Cojutti PG, Tascini C, Pecori D, Graziano E, and Tinghino B

Subjects
COVID-19, Female, Follow-Up Studies, Humans, Italy epidemiology, Male, Prevalence, Prospective Studies, SARS-CoV-2, Tobacco Smoking epidemiology, Betacoronavirus, Coronavirus Infections epidemiology, Life Style, Pandemics, Pneumonia, Viral epidemiology, Tobacco Smoking adverse effects
Abstract

The emergency caused by Covid-19 pandemic raised interest in studying lifestyles and comorbidities as important determinants of poor Covid-19 prognosis. Data on tobacco smoking, alcohol consumption and obesity are still limited, while no data are available on the role of e-cigarettes and heated tobacco products (HTP). To clarify the role of tobacco smoking and other lifestyle habits on COVID-19 severity and progression, we designed a longitudinal observational study titled COvid19 and SMOking in ITaly (COSMO-IT). About 30 Italian hospitals in North, Centre and South of Italy joined the study. Its main aims are: 1) to quantify the role of tobacco smoking and smoking cessation on the severity and progression of COVID-19 in hospitalized patients; 2) to compare smoking prevalence and severity of the disease in relation to smoking in hospitalized COVID-19 patients versus patients treated at home; 3) to quantify the association between other lifestyle factors, such as e-cigarette and HTP use, alcohol and obesity and the risk of unfavourable COVID-19 outcomes. Socio-demographic, lifestyle and medical history information will be gathered for around 3000 hospitalized and 700-1000 home-isolated, laboratory-confirmed, COVID-19 patients. Given the current absence of a vaccine against SARS-COV-2 and the lack of a specific treatment for -COVID-19, prevention strategies are of extreme importance. This project, designed to highly contribute to the international scientific debate on the role of avoidable lifestyle habits on COVID-19 severity, will provide valuable epidemiological data in order to support important recommendations to prevent COVID-19 incidence, progression and mortality.

Published
2020
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