28 results on '"Roussey, Gwenaëlle"'
Search Results
2. Renal and Extrarenal Phenotypes in Patients With HNF1B Variants and Chromosome 17q12 Microdeletions
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Ariceta, Gema, Benetti, Elisa, Benz, Marcus R., Bjerre, Anna, Boudailliez, Bernard R., Bouts, Antonia, Drube, Jens, Gjerstad, Ann Christin, Jankauskiene, Augustina, Jávorszky, Eszter, Jay, Nadine, Kirschstein, Martin, Varda, Nataša Marčun, Niel, Olivier, Nobili, François, Pietrement, Christine, Ruzgiene, Dovile, Schild, Raphael, Staude, Hagen, Tory, Kálmán, Tsimaratos, Michel, Walden, Ulrike, Zappel, Hildegard, Buffin-Meyer, Bénédicte, Richard, Juliette, Guigonis, Vincent, Weber, Stefanie, König, Jens, Heidet, Laurence, Moussaoui, Nabila, Vu, Jeanne-Pierrette, Faguer, Stanislas, Casemayou, Audrey, Prakash, Richa, Baudouin, Véronique, Hogan, Julien, Alexandrou, Demi, Bockenhauer, Detlef, Bacchetta, Justine, Ranchin, Bruno, Pruhova, Stepanka, Zieg, Jakub, Lahoche, Annie, Okorn, Christine, Antal-Kónya, Violetta, Morin, Denis, Becherucci, Francesca, Habbig, Sandra, Liebau, Max C., Mauras, Mathilde, Nijenhuis, Tom, Llanas, Brigitte, Mekahli, Djalila, Thumfart, Julia, Tönshoff, Burkhard, Massella, Laura, Eckart, Philippe, Cloarec, Sylvie, Cruz, Alejandro, Patzer, Ludwig, Roussey, Gwenaelle, Vrillon, Isabelle, Dunand, Olivier, Bessenay, Lucie, Taroni, Francesca, Zaniew, Marcin, Louillet, Ferielle, Bergmann, Carsten, Schaefer, Franz, van Eerde, Albertien M., Schanstra, Joost P., and Decramer, Stéphane
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- 2024
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3. The genetic landscape and clinical spectrum of nephronophthisis and related ciliopathies
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Attié-Bitach, Tania, Comier-Daire, Valerie, Rozet, Jean-Michel, Frishberg, Yaacov, Llanas, Brigitte, Broyer, Michel, Mohsin, Nabil, Macher, Marie-Alice, Philip, Nicole, Baudouin, Véronique, Brackman, Damian, Loirat, Chantal, Charbit, Marina, Dehennault, Maud, Guyot, Claude, Bataille, Pierre, Elting, Mariet, Deschenes, Georges, Gropman, Andrea, Guest, Geneviève, Gagnadoux, Marie-France, Nicoud, Philippe, Cochat, Pierre, Ranchin, Bruno, Bensman, Albert, Guerrot, Anne-Marie, Knebelmann, Bertrand, Bilge, Ilmay, Bruno, Danièle, Burtey, Stéphane, Rouvière, Caroline Rousset, Caudwell, Valérie, Morin, Denis, Dollfus, Hélène, Maisin, Anne, Hamel, Christian, Bieth, Eric, Gie, Sophie, Goodship, Judith, Roussey, Gwenaelle, La Selve, Hermine, Nivet, Hubert, Bessenay, Lucie, Caillez, Mathilde, Palcoux, Jean Bernard, Benoît, Stéphane, Dubot, Philippe, Fila, Marc, Giuliano, Fabienne, Iftene, Daouya, Kessler, Michele, Kwon, Theresa, Lahoche, Anine, Laurent, Audrey, Leclerc, Anne-Laure, Milford, David, Neuhaus, Thomas, Odent, Sylvie, Eckart, Philippe, Chauveau, Dominique, Niaudet, Patrick, Repetto, Horacio, Taque, Sophie, Bruel, Alexandra, Noel-Botte, Alexandra, Launay, Emma Allain, Allard, Lisa, Anlicheau, Dany, Adra, Anne-Laure, Garnier, Arnaud, Nagra, Arvind, Baatard, Remy, Bacchetta, Justine, Sadikoglu, Banu, Barnerias, Christine, Barthelemy, Anne, Basel, Lina, Bassilios, Nader, Ben Maiz, Hedi, Ben Moussa, Fatma, Benmati, Faïza, Berthaud, Romain, Bertholet, Aurélia, Blanchier, Dominique, Boffa, Jean Jacques, Bouchireb, Karim, Bouhabel, Ihab, Boukerroucha, Zakaria, Bourdat-Michel, Guylhène, Boute, Odile, Brochard, Karine, Caumes, Roseline, Elalaoui, Siham Chafai, Chamontin, Bernard, Chastang, Marie Caroline, Pietrement, Christine, Richer, Christine, Legendre, Christophe, Dahan, Karin, Dalla-Vale, Fabienne, Thibaudin, Damien, Dauvergne, Maxime, Davourie, Salandre, Debeukelaer, Martin, Delbet, Jean Daniel, Deltas, Constantinos, Graber, Denis, Devillars, Nadège, Diouf, Boucar, Fenzy, Martine Doco, André, Jean-Luc, Joly, Dominique, Fryer, Alan, Albano, Laetitia, Cassuto, Elisabeth, Pincon, Aline, Medeira, Ana, Chaussenot, Annabelle, Mensire-Marinier, Anne, Bouissou, Francois, Decramer, Stephane, Bottani, Armand, Hummel, Aurélie, Karras, Alexandre, Katz, Avi, Azema, Christine, Janbon, Bénédicte, Roussel, Bernard, Bonniol, Claude, Mariat, Christiophe, Champion, Gérard, Chantreuil, Deborah, Chassaing, Nicolas, Mousson, Christiane, Baudeau, Christine, Cuntz, Delphine Hafdar, Mignot, Cyril, Dehoux, Laurene, Lacombe, Didier, Hannedouche, Thierry, Mérieau, Elodie, Charlin, Emmanuelle, Gauthier, Eric, Plasse, Florent, Faguer, Stanislas, Lebas, Fanny, Demurger, Florence, Emma, Francesco, Cartault, François, Dumont, Geneviève, Godefroid, Nathalie, Guigonis, Vincent, Hillaire, Sophie, Groothoff, Jaap, Dudley, Jan, Jourde-Chiche, Noémie, El Karoui, Khalil, Krid, Saoussen, Coudert, Krier, Bencheick, Larbi, Yver, Laurent, Lavocat, Marie-Pierre, De Sagazan, Le Monies, Leroy, Valerie, Thibaudin, Lise, Ingulli, Liz, Gwanmesia, Lorraine, Burglen, Lydie, Saïd-Menthon, Marie-Hélène, Carrera, Marta, Nizon, Mathilde, Melander, Catherine, Foulard, Michel, Blayo, Monique, Prinseau, Jacques, Jay, Nadine, Brun, Nathalie, Camille, Nicolas, Nobili, François, Devuyst, Olivier, Ben Brahim, Ouafa, Parvex, Paloma, Sabourin, Laurence Perrin, Blanc, Philippe, Vanhille, Philippe, Galichon, Pierre, Pierrepont, Sophie, Planquois, Vincent, Poussard, Gwenaelle, Noble, Claire Pouteil, Allal, Radia, Bernard, Raphaelle, Mounet, Raynaud, Cahen, Rémi, Touraine, Renaud, Rigothier, Claire, Ryckewaert, Amélie, Sacquepee, Mathieu, El Chehadeh, Salima, Samaille, Charlotte, Haq, Shuman, Simckes, Ari, Lanoiselée, Stéphanie, Tellier, Stephanie, Subra, Jean-François, Cloarec, Sylvie, Tenenbam, Julie, Lamy, Thomas, Garraud, Valérie Drouin, Valette, Huguette, Meyssonnier, Vanina, Vargas-Poussou, Rosa, Snajer, Yves, Durault, Sandrine, Plaisier, Emmanuelle, Berard, Etienne, Fakhouri, Fadi, Louillet, Ferielle, Finielz, Paul, Fischbach, Michel, Foliguet, Bernard, Francois-Pradier, Hélène, Garaix, Florentine, Gerard, Marion, Rizzoni, Gianfranco, Gilbert, Brigitte, Glotz, Denis, Dubrasquet, Astrid Godron, Grünfeld, Jean-Pierre, Bollee, Guillaume, Hall, Michelle, Hansson, Sverker, Haye, Damien, Taffin, Hélène, Hildebrandt, Friedhelm, Hourmand, Maryvonne, Kayserili, Hümya, Tack, Ivan, Jacquemont, Marie Line, Fabre-Teste, Jennifer, Kashtan, Cliff, Van Hoeck, Kkoen, Klein, Alexandre, Knefati, Yannick, Knoers, Nine, Konrad, Martin, Lachaux, Alain, Landru, Isabelle, Landthaler, Gilbert, Lang, Philippe, Le Pogamp, Patrick, Legris, Tristan, Didailler, Catherine, Lobbedez, Thierry, de Parscau, Loïc, Pinson, Lucile, Maheut, Hervé, Duval-Arnould, Marc, Rio, Marlène, Gubler, Marie-Claire, Merville, Pierre, Mestrallet, Guillaume, Meunier, Maite, Moreau, Karine, Harambat, Jérôme, Morgan, Graeme, Mourad, Georges, Stuber, Niksic, Boespflug-Tanguy, Odile, Dunand, Olivier, Niel, Olivier, Ouali, Nacera, Malvezzi, Paolo, Jaoude, Pauline Abou, Pelletier, Solenne, Peltier, Julie, Petersen, M.B., Michel, Philippe, Rémy, Philippe, Philit, Jean-Baptiste, Pichault, Valérie, Billette de Villemeur, Thierry, Boudailliez, Bernard, Leheup, Bruno, Dossier, Claire, Djeddi, Djamal-Dine, Berland, Yves, Hurault de Ligny, Bruno, Rigden, Susan, Robino, Christophe, Rossi, Annick, Sarnacki, Sabine, Saidani, Messaoud, Sartorius, Albane Brodin, Schäfer, Elise, Laszlo, Sztriha, Thouret, Marie-Christine, Thuillier-Lecouf, Angélique, Trachtman, Howard, Trivin, Claire, Tsimaratos, Michel, Van Damme-Lombaerts, Rita, Willems, Marjolaine, Youssef, Michel, Zaloszyc, Ariane, Zawodnik, Alexis, Ziliotis, Marie-Julia, Petzold, Friederike, Billot, Katy, Chen, Xiaoyi, Henry, Charline, Filhol, Emilie, Martin, Yoann, Avramescu, Marina, Douillet, Maxime, Morinière, Vincent, Krug, Pauline, Jeanpierre, Cécile, Tory, Kalman, Boyer, Olivia, Burgun, Anita, Servais, Aude, Salomon, Remi, Benmerah, Alexandre, Heidet, Laurence, Garcelon, Nicolas, Antignac, Corinne, Zaidan, Mohamad, and Saunier, Sophie
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- 2023
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4. Fatal thrombotic microangiopathy case following adeno-associated viral SMN gene therapy
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Guillou, Julia, de Pellegars, Alice, Porcheret, Florence, Frémeaux-Bacchi, Véronique, Allain-Launay, Emma, Debord, Camille, Denis, Manon, Péréon, Yann, Barnérias, Christine, Desguerre, Isabelle, Roussey, Gwenaëlle, and Mercier, Sandra
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- 2022
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5. Social Deprivation Is Associated With Lower Access to Pre-emptive Kidney Transplantation and More Urgent-Start Dialysis in the Pediatric Population
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Driollet, Bénédicte, Bayer, Florian, Kwon, Theresa, Krid, Saoussen, Ranchin, Bruno, Tsimaratos, Michel, Parmentier, Cyrielle, Novo, Robert, Roussey, Gwenaelle, Tellier, Stéphanie, Fila, Marc, Zaloszyc, Ariane, Godron-Dubrasquet, Astrid, Cloarec, Sylvie, Vrillon, Isabelle, Broux, Françoise, Bérard, Etienne, Taque, Sophie, Pietrement, Christine, Nobili, François, Guigonis, Vincent, Launay, Ludivine, Couchoud, Cécile, Harambat, Jérôme, and Leffondré, Karen
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- 2022
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6. To biopsy or not to biopsy: Henoch-Schönlein nephritis in children, a 5-year follow-up study
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Avramescu, Marina, Lahoche, Annie, Hogan, Julien, Salomon, Rémi, Roussey, Gwenaëlle, Bacchetta, Justine, and Decramer, Stéphane
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Children -- Diseases ,Vasculitis -- Diagnosis -- Care and treatment ,Health - Abstract
Background The prognosis of Henoch-Schönlein purpura (HSP), IgA vasculitis, depends on kidney involvement. There is no consensus on the initiation of treatment for HSP nephritis (HSPN). Some centres start treatment before performing a kidney biopsy (KB) while in others, treatment is dictated by the importance of the clinical, biological and histological signs. The aim of this study was to evaluate which of these two approaches is associated with a better kidney outcome at 5-year follow-up. Methods This multicentre, retrospective, nonrandomised study included children treated for HSPN between 2006 and 2010 in a French paediatric nephrology unit. One group had an early KB at diagnosis (before starting treatment or in the 15 following days). In the second group, initial treatment was decided without performing a KB. Results Among the 107 children included, 63.5% had an early KB at diagnosis. Follow-up at 5 years was completed in 44 children (28 KB at diagnosis, 16 no KB at diagnosis). Median urine protein/creatinine at 5 years was 2.5 mg/mmol in the early biopsy diagnosis group and 12.5 mg/mmol in the non-biopsy group. An antiproteinuric treatment was given, at 5 years, to 35.7% of the early biopsy at diagnosis children and in 62.5% of the non-biopsied children. Conclusions Children with early KB at diagnosis seem to have a better renal outcome at 5 years compared to those without an early biopsy at diagnosis or biopsied later. However, this is a small patient cohort and data are missing. Further work is needed to build consensual guidelines on the management of HSPN in children. Graphical abstract, Author(s): Marina Avramescu [sup.1] , Annie Lahoche [sup.2] , Julien Hogan [sup.3] , Rémi Salomon [sup.1] , Gwenaëlle Roussey [sup.4] , Justine Bacchetta [sup.5] , Stéphane Decramer [sup.6] , Tim [...]
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- 2022
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7. Haemodynamic Effect of Dexmedetomidine During Pediatric Kidney Transplantation: A Single-Center Retrospective Study
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Monteil, Matéo, primary, Chenouard, Alexis, additional, Roussey, Gwenaëlle, additional, Bernardon, Rémi, additional, Gaultier, Aurélie, additional, and Porcheret, Florence, additional
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- 2024
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8. Standardization of the management of rheumatoid purpura nephropathy in the West of France. What are the repercussions on the renal sequelae?
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Salmon, Margaux, primary, Rousseau, Chloé, additional, Roussey, Gwenaëlle, additional, Jay, Nadine, additional, Cloarec, Sylvie, additional, Injeyan, Maud, additional, Ryckewaert, Amélie, additional, and Taque, Sophie, additional
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- 2024
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9. Recommandations vaccinales pour les enfants avec un syndrome néphrotique idiopathique
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Boyer, Olivia, Baudouin, Véronique, Bérard, Étienne, Biebuyck-Gougé, Nathalie, Dossier, Claire, Guigonis, Vincent, Audard, Vincent, Klifa, Roman, Leroy, Valérie, Ranchin, Bruno, Roussey, Gwenaëlle, Samaille, Charlotte, Tellier, Stéphanie, and Vrillon, Isabelle
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- 2020
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10. Ofatumumab treatment for nephrotic syndrome recurrence after pediatric renal transplantation
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Bernard, Josselin, Lalieve, Fanny, Sarlat, Julie, Perrin, Justine, Dehoux, Laurene, Boyer, Olivia, Godron-Dubrasquet, Astrid, Harambat, Jerome, Decramer, Stephane, Caillez, Mathilde, Bruel, Alexandra, Allain-Launay, Emma, Dantal, Jacques, and Roussey, Gwenaëlle
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- 2020
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11. Complement Gene Variants and Shiga Toxin–Producing Escherichia coli–Associated Hemolytic Uremic Syndrome: Retrospective Genetic and Clinical Study
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Frémeaux-Bacchi, Véronique, Sellier-Leclerc, Anne-Laure, Vieira-Martins, Paula, Limou, Sophie, Kwon, Theresa, Lahoche, Annie, Novo, Robert, Llanas, Brigitte, Nobili, François, Roussey, Gwenaëlle, Cailliez, Mathilde, Ulinski, Tim, Deschênes, Georges, Alberti, Corinne, Weill, François-Xavier, Mariani, Patricia, and Loirat, Chantal
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- 2019
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12. National survey of prevention and management of CMV infection in pediatric kidney transplantation in comparison to clinical practice guidelines
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Madden, Iona, primary, Baudouin, Véronique, additional, Charbit, Marina, additional, Ranchin, Bruno, additional, Roussey, Gwenaëlle, additional, Novo, Robert, additional, Garaix, Florentine, additional, Decramer, Stéphane, additional, Fila, Marc, additional, Merieau, Elodie, additional, Vrillon, Isabelle, additional, Zaloszyc, Ariane, additional, Hogan, Julien, additional, and Harambat, Jérôme, additional
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- 2022
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13. Une tension palpable
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Gasmi, Oussama, Roussey, Gwenaelle, and Tagorti, Maha
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- 2024
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14. To biopsy or not to biopsy: Henoch-Schönlein nephritis in children, a 5-year follow-up study
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Avramescu, Marina, primary, Lahoche, Annie, additional, Hogan, Julien, additional, Salomon, Rémi, additional, Roussey, Gwenaëlle, additional, Bacchetta, Justine, additional, Decramer, Stéphane, additional, Ulinski, Tim, additional, Barbe, Coralie, additional, and Pietrement, Christine, additional
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- 2021
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15. Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis
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Louis-Dit-Picard, Hélène, primary, Kouranti, Ilektra, additional, Rafael, Chloé, additional, Loisel-Ferreira, Irmine, additional, Chavez-Canales, Maria, additional, Abdel-Khalek, Waed, additional, Argaiz, Eduardo R., additional, Baron, Stéphanie, additional, Vacle, Sarah, additional, Migeon, Tiffany, additional, Coleman, Richard, additional, Do Cruzeiro, Marcio, additional, Hureaux, Marguerite, additional, Thurairajasingam, Nirubiah, additional, Decramer, Stéphane, additional, Girerd, Xavier, additional, O’Shaugnessy, Kevin, additional, Mulatero, Paolo, additional, Roussey, Gwenaëlle, additional, Tack, Ivan, additional, Unwin, Robert, additional, Vargas-Poussou, Rosa, additional, Staub, Olivier, additional, Grimm, Richard, additional, Welling, Paul A., additional, Gamba, Gerardo, additional, Clauser, Eric, additional, Hadchouel, Juliette, additional, and Jeunemaitre, Xavier, additional
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- 2020
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16. Treatment and outcome of congenital nephrotic syndrome
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Bérody, Sandra, primary, Heidet, Laurence, additional, Gribouval, Olivier, additional, Harambat, Jérome, additional, Niaudet, Patrick, additional, Baudouin, Veronique, additional, Bacchetta, Justine, additional, Boudaillez, Bernard, additional, Dehennault, Maud, additional, de Parscau, Loïc, additional, Dunand, Olivier, additional, Flodrops, Hugues, additional, Fila, Marc, additional, Garnier, Arnaud, additional, Louillet, Ferielle, additional, Macher, Marie-Alice, additional, May, Adrien, additional, Merieau, Elodie, additional, Monceaux, Françoise, additional, Pietrement, Christine, additional, Rousset-Rouvière, Caroline, additional, Roussey, Gwenaëlle, additional, Taque, Sophie, additional, Tenenbaum, Julie, additional, Ulinski, Tim, additional, Vieux, Rachel, additional, Zaloszyc, Ariane, additional, Morinière, Vincent, additional, Salomon, Rémi, additional, and Boyer, Olivia, additional
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- 2018
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17. Liste des collaborateurs
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Bacchetta, Justine, Boyer, Olivia, Adonis-Koffy, Laurence Ya, Allain-Launay, Emma, Allard, Lise, Audard, Vincent, Baudin, Florent, Baudouin, Véronique, Beauvais, Anne, Belot, Alexandre, Bensman, Albert, Bérard, Étienne, Berteloot, Laureline, Berthaud, Romain, Bertholet-Thomas, Aurélia, Bertocchio, Jean-Philippe, Biebuyck, Nathalie, Bonnefoy, Catherine, Botto, Nathalie, Boubred, Farid, Bowman, Lucie, Broux, Françoise, Cailliez, Mathilde, Cambier, Alexandra, Capito, Carmen, Charbit, Marina, Chardot, Christophe, Claris, Olivier, Clavé, Stéphanie, Cochat, Pierre, Collard, Laure, Coste, Marie-Édith, Dalodier, Emmeline, Demède, Delphine, Deschênes, Georges, Dijoud, Frédérique, Dossier, Claire, Dubourg, Laurence, Exantus, Judith, Fargue, Sonia, Fila, Marc, Frémeaux-Bacchi, Véronique, Garaix, Florentine, Garnier, Charlotte, Gillet, Yves, Gonçalves, David, Gubler, Marie-Claire, Guigonis, Vincent, Harambat, Jérôme, Hazan, Myriam, Heidet, Laurence, Hogan, Julien, Hureaux, Marguerite, Iacobelli, Sylvia, Jamin, Agnès, Jouret, François, Keller-Petrot, Isabelle, Kohaut, Jules, Krid, Saoussen, Krug-Tricot, Pauline, Kwon, Theresa, de Labriolle-Vaylet, Claire, Lachaux, Alain, Launay, Élise, Lemoine, Sandrine, Linglart, Agnès, Manucci-Lahoche, Annie, Massardier, Jérôme, Mekahli, Djalila, Morin, Denis, Nathanson, Sylvie, Naud, Corentin, Nobili, François, Novo, Robert, de Parscau, Loïc, Parvex, Paloma, Perrin, Justine, Picard, Cécile, Piètrement, Christine, Putoux, Audrey, Rabant, Marion, Ranchin, Bruno, Robert, Thomas, Rousset-Rouvière, Caroline, Roussey, Gwenaelle, Ryckewaert, Amélie, Salomon, Rémi, Sellier-Leclerc, Anne-Laure, Sérusclat, André, Tanné, Corentin, Thaunat, Olivier, Tsimaratos, Michel, Ulinski, Tim, Vargas-Poussou, Rosa, Vrillon, Isabelle, Zaloszyc, Ariane, and Zennaro, Maria Christina
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- 2020
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18. Treatment by immunoadsorption for recurrent focal segmental glomerulosclerosis after paediatric kidney transplantation: a multicentre French cohort
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Allard, Lise, primary, Kwon, Theresa, additional, Krid, Saoussen, additional, Bacchetta, Justine, additional, Garnier, Arnaud, additional, Novo, Robert, additional, Deschenes, Georges, additional, Salomon, Rémi, additional, Roussey, Gwenaëlle, additional, and Allain-Launay, Emma, additional
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- 2017
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19. Stability and Compatibility of Antibiotics in Peritoneal Dialysis Solutions Applied to Automated Peritoneal Dialysis in the Pediatric Population
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Deslandes, Guillaume, primary, Grégoire, Matthieu, additional, Bouquié, Régis, additional, Le Marec, Aude, additional, Allard, Sophie, additional, Dailly, Eric, additional, Pineau, Alain, additional, Allain-Launay, Emma, additional, Jolliet, Pascale, additional, Roussey, Gwenaëlle, additional, and Navas, Dominique, additional
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- 2016
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20. Simplified pulse wave velocity measurement in children: A validation study of the pOpmètre®
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Bichali, Saïd, Bruel, Alexandra, Boivin, Marion, Roussey, Gwénaëlle, Romefort, Bénédicte, Rozé, Jean-Christophe, and Allain-Launay, Emma
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- 2019
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21. B7–1 Blockade Does Not Improve Post–Transplant Nephrotic Syndrome Caused by Recurrent FSGS
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Delville, Marianne, primary, Baye, Emilie, additional, Durrbach, Antoine, additional, Audard, Vincent, additional, Kofman, Tomek, additional, Braun, Laura, additional, Olagne, Jérôme, additional, Nguyen, Clément, additional, Deschênes, Georges, additional, Moulin, Bruno, additional, Delahousse, Michel, additional, Kesler-Roussey, Gwenaëlle, additional, Beaudreuil, Séverine, additional, Martinez, Frank, additional, Rabant, Marion, additional, Grimbert, Philippe, additional, Gallazzini, Morgan, additional, Terzi, Fabiola, additional, Legendre, Christophe, additional, and Canaud, Guillaume, additional
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- 2015
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22. Treatment by immunoadsorption for recurrent focal segmental glomerulosclerosis after paediatric kidney transplantation: a multicentre French cohort.
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Allard, Lise, Kwon, Theresa, Krid, Saoussen, Bacchetta, Justine, Garnier, Arnaud, Novo, Robert, Deschenes, Georges, Salomon, Rémi, Roussey, Gwenaëlle, and Allain-Launay, Emma
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FOCAL segmental glomerulosclerosis ,IMMUNOADSORPTION ,KIDNEY transplantation ,PEDIATRIC surgery ,GRAFT rejection ,HEMAPHERESIS ,THERAPEUTICS - Abstract
Background. Primary focal segmental glomerulosclerosis (FSGS) frequently recurs after kidney transplantation (KTx) in children. This can lead to delayed graft loss. As themanagement of children with recurrent FSGS is not well established, apheresis strategies could be a cornerstone to control the disease. Immunoadsorption (IA) is a recent apheresis therapy. There have been few studies examining IA in this setting.We report the results of IA for management of recurrent FSGS after KTx in children in France. Methods. We included all children treated with IA for early FSGS recurrence after KTx between January 2011 and June 2014 in France. We excluded genetic forms of FSGS. Patients' characteristics and technical data on IA were retrospectively collected. Recurrence was defined as nephrotic proteinuria during the post-transplantation period. Partial and complete remissions were defined when urine protein:creatinine ratios were less than 0.2 and 0.05 g/mmol, respectively. Results. Twelve patients, from six paediatric KTx units, presenting with FSGS recurrence between 0 and 21 days after KTx were treated with IA. Ten of 12 children were responders: 2 achieved partial remission and 8 complete remission. The decrease of proteinuria rapidly occurred within the first 10 sessions after initiating IA. After 3months of IA, two patients maintained remission without IA and eight became IA dependent. No severe side effects were reported. Conclusions. Our study reports on the efficacy of IA in the recurrence of FSGS after KTx in children. Further prospective controlled studies are required to confirm these results and to optimize themanagement of FSGS recurrence after paediatric KTx. [ABSTRACT FROM AUTHOR]
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- 2018
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23. A case of hypercalcemia Indications for 1,25-dihydroxyvitamin D prescription
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Malandain, Damasie, additional, Roussey, Gwenaëlle, additional, Leloupp, Anne-Gaelle, additional, Graveline, Nolwenn, additional, Masson, Damien, additional, and Bach-Ngohou, Kalyane, additional
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- 2015
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24. Fatal Thrombotic Microangiopathy Case following Adeno-Associated Viral SMNGene Therapy
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Guillou, Julia, de Pellegars, Alice, Porcheret, Florence, Frémeaux-Bacchi, Véronique, Allain-Launay, Emma, Debord, Camille, Denis, Manon, Péréon, Yann, Barnérias, Christine, Desguerre, Isabelle, Roussey, Gwenaëlle, and Mercier, Sandra
- Abstract
Adeno-Associated Virus (AAV) gene therapies are highly promising, such as the onasemnogene abeparvovec (Zolgensma®) in Spinal Muscle Atrophy (SMA). We report the first case of fatal systemic Thrombotic MicroAngiopathy (TMA) following onasemnogene abeparvovec in a 6-month-old child with SMA type 1, carrying a potential genetic predisposition in the Complement Factor I gene. Other cases of TMA have recently been reported after onasemnogene abeparvovec, and after AAV9 minidystrophin therapy in the Duchenne muscular dystrophy. The risk-benefit ratio of this therapy must therefore be assessed. Early recognition of TMA and targeted immunotherapy are fundamental to ensure the safety of patients treated with AAV gene therapies.
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- 2022
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25. [Vaccine recommendations for children with idiopathic nephrotic syndrome].
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Boyer O, Baudouin V, Bérard É, Biebuyck-Gougé N, Dossier C, Guigonis V, Audard V, Klifa R, Leroy V, Ranchin B, Roussey G, Samaille C, Tellier S, and Vrillon I
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- Child, Humans, Immunosuppressive Agents therapeutic use, Vaccination, Nephrosis, Lipoid, Nephrotic Syndrome drug therapy, Vaccines
- Abstract
The specific treatment of idiopathic nephrotic syndrome is based on corticosteroid therapy and/or steroid-sparing immunosuppressive agents in children who are steroid-dependant or frequent relapsers (60-70 %). Patients have an increased infectious risk not only related to the disease during relapses (hypogammaglobulinemia and urinary leakage of opsonins) but also to treatments (corticosteroids or immunosuppressive agents) in period of remission. Vaccination is therefore particularly recommended in these patients. Potential vaccine risks are ineffectiveness, induction of vaccine disease and relapse of idiopathic nephrotic syndrome. Only live vaccines expose to the risk of vaccine disease: they are in general contra-indicated under immunosuppressive treatment. The immunogenicity of inactivated vaccines is reduced but persists. The immunogenic stimulus of vaccination may in theory trigger a relapse of the nephrotic syndrome. Nevertheless, this risk is low in the literature, and even absent in some studies. The benefit-risk ratio is therefore in favor of vaccination with respect to the vaccination schedule for inactivated vaccines, with wide vaccination against pneumococcus and influenza annually. Depending on the context and after expert advice, immunization with live vaccines could be discussed if residual doses/levels of immunosuppressive treatments are moderate and immunity preserved., (Copyright © 2020. Published by Elsevier Masson SAS.)
- Published
- 2020
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26. Treatment and outcome of congenital nephrotic syndrome.
- Author
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Bérody S, Heidet L, Gribouval O, Harambat J, Niaudet P, Baudouin V, Bacchetta J, Boudaillez B, Dehennault M, de Parscau L, Dunand O, Flodrops H, Fila M, Garnier A, Louillet F, Macher MA, May A, Merieau E, Monceaux F, Pietrement C, Rousset-Rouvière C, Roussey G, Taque S, Tenenbaum J, Ulinski T, Vieux R, Zaloszyc A, Morinière V, Salomon R, and Boyer O
- Subjects
- Disease Progression, Female, France epidemiology, Humans, Incidence, Infant, Infant, Newborn, Male, Nephrotic Syndrome epidemiology, Nephrotic Syndrome genetics, Nephrotic Syndrome therapy, Retrospective Studies, Survival Rate, Treatment Outcome, Membrane Proteins genetics, Mutation, Nephrectomy mortality, Nephrotic Syndrome mortality
- Abstract
Background: Recommendations for management of Finnish-type congenital nephrotic syndrome (CNS) followed by many teams include daily albumin infusions, early bilateral nephrectomy, dialysis and transplantation. We aimed to assess the treatment and outcome of patients with CNS in France., Methods: We conducted a nationwide retrospective study on 55 consecutive children born between 2000 and 2014 treated for non-infectious CNS., Results: The estimated cumulative incidence of CNS was 0.5/100 000 live births. The underlying defect was biallelic mutations in NPHS1 (36/55, 65%), NPHS2 (5/55, 7%), PLCE1 (1/55, 2%), heterozygous mutation in WT1 (4/55, 7%) and not identified in nine children (16%). Fifty-three patients (96%) received daily albumin infusions from diagnosis (median age 14 days), which were spaced and withdrawn in 10 patients. Twenty children (35%) were managed as outpatients. Thirty-nine patients reached end-stage kidney disease (ESKD) at a median age of 11 months. The overall renal survival was 64% and 45% at 1 and 2 years of age, respectively. Thirteen children died during the study period including four at diagnosis, two of nosocomial catheter-related septic shock, six on dialysis and one after transplantation. The remaining 13 patients were alive with normal renal function at last follow-up [median 32 months (range 9-52)]. Renal and patient survivals were longer in patients with NPHS1 mutations than in other patients. The invasive infection rate was 2.41/patient/year., Conclusions: Our study shows: (i) a survival free from ESKD in two-thirds of patients at 1 year and in one-half at 2 years and (ii) a significant reduction or even a discontinuation of albumin infusions allowing ambulatory care in a subset of patients. These results highlight the need for new therapeutic guidelines for CNS patients., (© The Author(s) 2018. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.)
- Published
- 2019
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27. B7-1 Blockade Does Not Improve Post-Transplant Nephrotic Syndrome Caused by Recurrent FSGS.
- Author
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Delville M, Baye E, Durrbach A, Audard V, Kofman T, Braun L, Olagne J, Nguyen C, Deschênes G, Moulin B, Delahousse M, Kesler-Roussey G, Beaudreuil S, Martinez F, Rabant M, Grimbert P, Gallazzini M, Terzi F, Legendre C, and Canaud G
- Subjects
- Adult, Child, Child, Preschool, Female, Humans, Male, Middle Aged, Prospective Studies, Recurrence, Treatment Failure, Young Adult, Abatacept pharmacology, Abatacept therapeutic use, B7-1 Antigen antagonists & inhibitors, Glomerulosclerosis, Focal Segmental complications, Immunosuppressive Agents pharmacology, Immunosuppressive Agents therapeutic use, Kidney Transplantation, Nephrotic Syndrome etiology, Nephrotic Syndrome prevention & control, Postoperative Complications etiology, Postoperative Complications prevention & control
- Abstract
FSGS is a common glomerular disorder that has a high propensity for recurrence after kidney transplant. The pathophysiology of FSGS is unknown, but podocytes seem to be the target of one or several circulating factors that lead to cytoskeleton reorganization and proteinuria. Research on podocytes has identified B7-1 as an important factor in podocyte biology and a new therapeutic target in renal disease. Indeed, in four patients with recurrent FSGS after transplant, treatment with the B7-1 blocker abatacept was associated with proteinuria remission. Here, we prospectively treated nine patients with recurrent FSGS after transplant using either abatacept or belatacept, a B7-1 blocker with higher affinity, and did not induce proteinuria remission. Furthermore, we did not detect B7-1 expression by immunofluorescence in podocytes of biopsy specimens from these or other kidney grafts or podocytes of native kidney biopsy specimens. In conclusion, B7-1 blockade did not induce FSGS remission after transplant in our study., (Copyright © 2016 by the American Society of Nephrology.)
- Published
- 2016
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28. Stability and Compatibility of Antibiotics in Peritoneal Dialysis Solutions Applied to Automated Peritoneal Dialysis in The Pediatric Population.
- Author
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Deslandes G, Grégoire M, Bouquié R, Le Marec A, Allard S, Dailly E, Pineau A, Allain-Launay E, Jolliet P, Roussey G, and Navas D
- Subjects
- Adolescent, Automation, Cefazolin chemistry, Cefepime, Ceftazidime chemistry, Cephalosporins chemistry, Child, Chromatography, High Pressure Liquid, Female, Glucans chemistry, Glucose chemistry, Humans, Icodextrin, In Vitro Techniques, Male, Peritoneal Dialysis adverse effects, Peritonitis etiology, Sensitivity and Specificity, Tobramycin chemistry, Vancomycin chemistry, Anti-Bacterial Agents chemistry, Dialysis Solutions chemistry, Drug Stability, Peritoneal Dialysis methods, Peritonitis prevention & control
- Abstract
♦ OBJECTIVES: Assess the stability of several antibiotics in peritoneal dialysis (PD) solutions under common conditions of use in pediatrics, particularly in automated PD. ♦ METHODS: Amoxicillin, cefazolin, cefepime, ceftazidime, imipenem, cotrimoxazole, tobramycin, vancomycin, and the association of ceftazidime + vancomycin and ceftazidime + tobramycin, were tested in 3 different PD solutions: bicarbonate/lactate solution with 2 glucose concentrations (Physioneal 1.36 and 3.86%; Baxter Healthcare Corporation, Deerfield, IL, USA) and an icodextrin-containing solution (Extraneal; Baxter Healthcare Corporation, Deerfield, IL, USA). Concentrations were those recommended in guidelines for the treatment of peritonitis in pediatrics. Physioneal bags were incubated at 37°C for 24 hours, whereas Extraneal bags were stored 12 hours at room temperature (22 ± 2°C) and then 12 hours at 37°C. Drug concentrations were determined using high performance liquid chromatography (HPLC). Each measure was taken in triplicate. Stability of antibiotics was defined as less than 10% degradation of the drug over time. ♦ RESULTS: Cefazolin, cotrimoxazole, tobramycin, and vancomycin were stable under studied conditions. Ceftazidime was stable 24 hours in icodextrin, 12 hours in Physioneal 1.36% and 6 hours in Physioneal 3.86%. The association of tobramycin or vancomycin did not influence the stability of ceftazidime. Cefepime and amoxicillin were stable 6 h, 4 h, and 8 h in Physioneal 1.36%, 3.86% and Extraneal, respectively. The stability of imipenem was very low: 2 h in Physioneal and 6 h in Extraneal. Moreover, an increasingly yellow coloration was observed with the use of imipenem, whereas no color change or precipitation occurred in other bags. ♦ CONCLUSION: Cefazolin, tobramycin, cotrimoxazole, and vancomycin are stable in PD solutions up to 24 hours and can be administered in the PD bag for the treatment of peritonitis, even in automated PD under studied conditions. However, amoxicillin, cefepime, ceftazidime, and imipenem must be used with caution due to their lack of stability., (Copyright © 2016 International Society for Peritoneal Dialysis.)
- Published
- 2016
- Full Text
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