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1. naked cuticle targets dishevelled to antagonize Wnt signal transduction

Author

Rouseet, Raphael, Mack, Judith A., Wharton, Keith A., Jr., Axelrod, Jeffrey D., Cadigan, Ken M., Fish, Matthew P., Nusse, Roel, and Scott, Matthew P.

Subjects
Drosophila -- Genetic aspects, Embryology, Experimental -- Genetic aspects, Cell differentiation -- Genetic aspects, Cellular signal transduction -- Research, Cytogenetics -- Research, Biological sciences
Abstract

The ways in which Nkd limits Wg signaling by using a combination of genetic and biochemical approaches are discussed. Study results indicate that Nkd likely can antagonize Wg signaling cell-autonomously through a direct interaction with Dsh. In Drosophila embryos the protein Naked cuticle limits effects of the Wnt signal Wingless in early segmentation.

Published
2001

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