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Your search keyword '"Roullin, V. Gaëlle"' showing total 28 results
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28 results on '"Roullin, V. Gaëlle"'

8. List of Contributors

Author

Akbari-Alavijeh, Safoura, primary, Assadpour, Elham, additional, Babazadeh, Afshin, additional, Chatzidaki, Maria D., additional, Donsì, Francesco, additional, Esposito, Cloé L., additional, Ghanbarzadeh, Babak, additional, Gutiérrez, Gemma, additional, Jafari, Seid Mahdi, additional, Keivani, Fatemeh, additional, Khodaei, Diako, additional, Kirilov, Plamen, additional, Matos, María, additional, Mohammadi, Maryam, additional, Nejatian, Mohammad, additional, Pando, Daniel, additional, Papadimitriou, Vassiliki, additional, Rafiee, Zahra, additional, Roullin, V Gaëlle, additional, Saberian, Hamed, additional, Sarabandi, Khashayar, additional, Shaddel, Rezvan, additional, Shi, Bingyang, additional, Velikov, Krassimir P., additional, Xenakis, Aristotelis, additional, and Yaghmur, Anan, additional

Published
2019
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19. PLGA nanoparticles optimized by Box-Behnken for efficient encapsulation of therapeutic Cymbopogon citratus essential oil

Author

Almeida, Kessiane B., primary, Ramos, Aline S., additional, Nunes, Júlia B.B., additional, Silva, Bianca O., additional, Ferraz, Elisa R.A., additional, Fernandes, Andreia S., additional, Felzenszwalb, Israel, additional, Amaral, Ana Claudia F., additional, Roullin, V. Gaëlle, additional, and Falcão, Deborah Q., additional

Published
2019
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24. Neuronal Uptake and Neuroprotective Properties of Curcumin-Loaded Nanoparticles on SK-N-SH Cell Line: Role of Poly(lactide-co-glycolide) Polymeric Matrix Composition

Author

Djiokeng Paka, Ghislain, primary, Doggui, Sihem, additional, Zaghmi, Ahlem, additional, Safar, Ramia, additional, Dao, Lé, additional, Reisch, Andreas, additional, Klymchenko, Andrey, additional, Roullin, V. Gaëlle, additional, Joubert, Olivier, additional, and Ramassamy, Charles, additional

Published
2015
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27. Neuronal Uptake and Neuroprotective Properties of Curcumin-Loaded Nanoparticles on SK-N-SH Cell Line: Role of Poly(lactide-co-glycolide) Polymeric Matrix Composition

Author

Djiokeng Paka, Ghislain, Doggui, Sihem, Zaghmi, Ahlem, Safar, Ramia, Dao, Lé, Reisch, Andreas, Klymchenko, Andrey, Roullin, V. Gaëlle, Joubert, Olivier, and Ramassamy, Charles

Abstract

Curcumin, a neuroprotective agent with promising therapeutic approach has poor brain bioavailability. Herein, we demonstrate that curcumin-encapsulated poly(lactide-co-glycolide) (PLGA) 50:50 nanoparticles (NPs-Cur 50:50) are able to prevent the phosphorylation of Akt and Tau proteins in SK-N-SH cells induced by H2O2and display higher anti-inflammatory and antioxidant activities than free curcumin. PLGA can display various physicochemical and degradation characteristics for controlled drug release applications according to the matrix used. We demonstrate that the release of curcumin entrapped into a PLGA 50:50 matrix (NPs-Cur 50:50) is faster than into PLGA 65:35. We have studied the effects of the PLGA matrix on the expression of some key antioxidant- and neuroprotective-related genes such as APOE, APOJ, TRX, GLRX, and REST. NPs-Cur induced the elevation of GLRX and TRX while decreasing APOJ mRNA levels and had no effect on APOE and REST expressions. In the presence of H2O2, both NPs-Cur matrices are more efficient than free curcumin to prevent the induction of these genes. Higher uptake was found with NPs-Cur 50:50 than NPs-Cur 65:35 or free curcumin. By using PLGA nanoparticles loaded with the fluorescent dye Lumogen Red, we demonstrated that PLGA nanoparticles are indeed taken up by neuronal cells. These data highlight the importance of polymer composition in the therapeutic properties of the nanodrug delivery systems. Our study demonstrated that NPs-Cur enhance the action of curcumin on several pathways implicated in the pathophysiology of Alzheimer’s disease (AD). Overall, these results suggest that PLGA nanoparticles are a promising strategy for the brain delivery of drugs for the treatment of AD.

Published
2016
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28. Etoposide encapsulation in surface-modified poly(lactide- co-glycolide) nanoparticles strongly enhances glioma antitumor efficiency.

Author

Callewaert, Maïté, Dukic, Sylvain, Van Gulick, Laurence, Vittier, Mélanie, Gafa, Valérie, Andry, Marie‐Christine, Molinari, Michaël, and Roullin, V. Gaëlle

Abstract

Etoposide (VP-16) is a hydrophobic anticancer agent inhibiting Topoisomerase II, commonly used in pediatric brain chemotherapeutic schemes as mildly toxic. Unfortunately, despite its appropriate solubilization in vehicle solvents, its poor bioavailability and limited passage of the blood-brain barrier concur to disappointing results requiring the development of new delivery system forms. In this study, etoposide formulated as a parenteral injectable solution (Teva®) was loaded into all-biocompatible poly(lactide- co-glycolide) (PLGA) or PLGA/P188-blended nanoparticles (size 110-130 nm) using a fully biocompatible nanoprecipitation technique. The presence of coprecipitated P188 on encapsulation efficacies and in vitro drug release was investigated. Drug encapsulation was determined using HPLC. Inflammatory response was checked by FACS analysis on human monocytes. Cytotoxic activity of the various simple (Teva®) or double (Teva®-loaded NPs) formulations was studied on the murine C6 and F98 cell lines. Obtained results suggest that, although noninflammatory neither nontoxic by themselves, the use of PLGA and PLGA/P188 nanoencapsulations over pre-existing etoposide formulation could induce a greatly improved cytotoxic activity. This approach demonstrated a promising perspective for parenteral delivery of VP16 and potential development of a therapeutic entity. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013. [ABSTRACT FROM AUTHOR]

Published
2013
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