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This paper presents a finite element model of the ankle, taking into account the effects of muscle forces, determined by a musculoskeletal analysis, to investigate the contact stress distribution in the tibio-talar joint in patients with triple arthrodesis and in normal subjects. Forces of major ankle muscles were simulated and corresponded well with the trend of their EMG signals. These forces were applied to the finite element model to obtain stress distributions for patients with triple arthrodesis and normal subjects in three stages of the gait cycle, i.e. heel strike, midstance, and heel rise. The results demonstrated that the stress distribution patterns of the tibio-talar joint in patients with triple arthrodesis differ from those of normal subjects in investigated gait cycle stages. The mean and standard deviations for maximum stresses in the tibo-talar joint in the stance phase for patients and normal subjects were 9.398e7 ± 1.75e7 and 7.372e7 ± 4.43e6 Pa, respectively. The maximum von Mises stresses of the tibio-talar joint for all subjects in the stance phase found to be on the lateral side of the inferior surface of the joint. The results also indicate that, in patients with triple arthrodesis, increasing gastrocnemius–soleus muscle force reduces the stress on the medial malleolus compared with normal subjects. Most of stresses in this area are between 45 and 109 kPa, and will decrease to almost 32 kPa in patients after increasing of 40% in gastrocnemius–soleus muscle force. [ABSTRACT FROM AUTHOR]

Introduction: Optimal performance of hospitals is depending on effective management of human and equipment. Nurse as most parts of human resource of hospitals have numerous occupational difficulties. Burnout is on of these problems that threat the physical and psychological health of nurse and is one of the impotent causes of absence, energy depletion and low efficiency among nursing staff. Aim: purpose of this study was the assessment of relationship between management approach of nurse administrators and Occupational burnout among nurses' staff of Golestan University hospitals. Methodology: Study design was descriptive and analytical. 272 nurses from Golestan Province University hospitals were assess with by Maslach Burnout Inventory (MBI) and management approach questionnaire. MBI assess emotional exhaustion, depersonalization and personal accomplishment and management approach questionnaire included planning, organizing, control, leadership, motivation, staff participation, reward and punishment. The statistical analysis was done by SPSS for windows. C-square and U-man-witny test were applied for analyses in this study. Finding: The age range of nurses were 29-45 years and, 95 of them were male and 177 were female (60 single and 206 married). 5.5 % of staff rated their head nurses' management approach very good, 51.15% partially good and 0.7% of them perceived it completely bad. There was a significant relationship between management approach of head nurses with Occupational burnout of nurses staff in terms of intensity and frequency of burnout (P

Even though, proximal tibia is a common site of giant cell tumor and bone fractures, following tumor removal, nonetheless very little attention has been paid to affecting factors on the fracture risk. Here, nonlinear voxel-based finite element models based on computed tomography images were developed to predict bone fracture load with defects with different sizes, which were located in the medial, lateral, anterior, and posterior region of the proximal tibia. Critical defect size was identified using One-sample t-test to assess if the mean difference between the bone strength for a defect size was significantly different from the intact bone strength. Then, the defects larger than critical size were reconstructed with cement and the mechanics of the bone-cement interface (BCI) was investigated to find the regions prone to separation at BCI. A significant increase in fracture risk was observed for the defects larger than 20 mm, which were located in the medial, lateral and anterior regions, and defects larger than 25 mm for those located in the posterior region of the proximal tibia. Furthermore, it was found that the highest and lowest fracture risks were associated with defects located in the medial and posterior regions, respectively, highlighting the importance of selecting the initial location of a cortical window for tumor removal by the surgeon. The results of the BCI analysis showed that the location and size of the cement had a direct impact on the extent of damage and its distribution. Identification of critical regions susceptible to separation at BCI, can provide critical comments to surgeons in selecting the optimal cement augmentation technique, which may ultimately prevent unnecessary surgical intervention, such as using screws and pins., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)

Primary stability of a dental implant is defined as its ability to resist the applied load without showing excessive damage in peri-implant bone, which is a prerequisite for secondary stability, and consequently for implantation success. The main goal of this study was to develop a validated micro-finite element (μFE) approach to assess the primary stability of dental implants in terms of stiffness, stiffness reduction, and irreversible displacement of the bone-implant system, subjected to an increasing step-wise quasi-static compressive loading-unloading test. The μFE models were generated based on the μCT images of bone, taken from extracted bovine tibia trabecular bone samples after drilling and implantation. A tissue constitutive model was considered for trabecular bone by describing elasto-plasticity with a modified von Mises yield criterion and element deletion technique to account for trabecular bone damage behavior. Then, the obtained force-displacement curves from the simulation were compared with the in-vitro mechanical test curves to evaluate the validity of the model. The results showed that the proposed μFE model could be properly predict the bone-implant system mechanical response in terms of irreversible displacement (R 2  = 0.99), stiffness (R 2  = 0.77), and stiffness reduction (R 2  = 0.72) of the bone-implant construct for all the applied displacements without a significant difference from the unit slope and zero intercept of the QQ-plot (p-value<0.05). Moreover, a qualitative agreement was seen between the peri-implant bone damage predicted by the μFE model and the observed from μCT images. The adopted methodology used in this study can predict the mechanical failure response of the bone-implant system, which can be employed as a representative tool to study the effects of various dental implant design parameters on the primary stability with the ultimate goal of optimizing dental implants design., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)

Statement of Problem: Lack of knowledge regarding the optimal design of thread configuration in dental implants, which can offer a satisfactory level of stability in the implant-bone construct, is a significant challenge in the field of dental biomechanics., Purpose: The purpose of this finite element analysis study was to identify the optimal thread design by investigating the effects of thread parameters such as thread depth (TD), thread width (TW), and thread pitch (TP), as well as upper (α) and lower (β) thread angles, on the maximum principal stress in cancellous and cortical bone, maximum von Mises stress in the dental implant, and maximum shear stress at the implant-bone interface., Material and Methods: A finite element model of an alveolar bone segment with a dental implant was developed. The Latin hypercube sampling method was used to generate a dataset of virtual experiments, which were analyzed by using the decision tree method to identify suitable thread designs that minimize mechanical stimuli. Additionally, the effectiveness of thread parameters on stress levels in the bone, implant, and their interface were assessed., Results: The results of this study, verified by comparison with previous literature, indicated that TD, TW, and upper thread angle were the most effective parameters in promoting implant stability., Conclusions: By analyzing the decision trees, optimum ranges for all the thread parameters were determined as follows: 0.25

Periodontal ligament (PDL) plays a crucial role in transferring load from tooth to its adjacent bone, and its role is more pronounced in case of trauma, due to its shock-absorbing character, which has not been fully understood yet. Different constitutive models have correlated mechanical function of PDL with its anisotropic, inhomogeneous, non-linear elastic nature, and it was variably modeled using Finite Element (FE) simulations of dental trauma. Furthermore, since capturing accurate dimension of PDL is difficult, various thicknesses were considered for PDL in FE reconstruction process. In this study, the sensitivity of FE analyses to variation in mechanical properties, including a large range of elastic properties for a linear elastic model, also a hyper-elastic material model, and various thicknesses of PDL was investigated by developing a CT-based FE model of tooth-PDL-bone complex. Results of this study highlighted the crucial role of PDL in absorption and dissipation of energy, as well as in stress distribution within alveolar bone during dental trauma. It was observed that as Young's modulus of PDL decreases and its thickness increases, its shock-absorbing capacity would be escalated. Moreover, it was found that inclusion of PDL reduces the maximum von Mises stress exerted on the alveolar bone by about 60% in some areas, compared to the case in which the PDL is absent. Results of this work underscore the need of presenting comprehensive constitutive models to describe mechanical behavior of PDL, with the goal of understanding the behavior of a tooth-PDL-bone complex in pathological conditions, such as trauma.

Background and Objective: The threads, as the most critical component of dental implants, transfer the imposed occlusal loads to the adjacent bone. Moreover, regulation of the mechanical stimuli in the implant adjacent bone is crucial to maximize the bone-implant construct stability. An optimal thread design can be resulted when the distribution of mechanical stimuli within the bone, and at the implant-bone interface, lie in an advised confined range. In this work, with the goal of finding the optimal thread design, which can provide the maximum level of stability, the effects of thread parameters, namely, thread depth, thread width, and thread pitch, together with upper and lower thread angles, on maximum principal strain within the cortical and cancellous bone, and shear strain at the implant-bone interface, were investigated., Methods: In this study, the response surface methodology (RSM), due to the central composite design (CCD), was employed to obtain a set of 53 experiments. Following that, they were numerically simulated using the finite element method (FEM). The polynomial regression model was then used to predict the response functions based on the magnitude of thread parameters. The effectiveness of each thread parameter was also evaluated through statistical tools. Moreover, the non-dominated sorting genetic algorithm (NSGA-II) was performed to find the optimum dimensions of the thread., Results: Through comparing the results obtained from analyzing initial and optimized configuration of threads, it was shown that the latter causes a reduction in the maximum principal strains in cancellous and cortical bones by about 25% and 30%, respectively, which is in favor of making a higher quality bone, and thus greater stability in dental implant-bone construct. Moreover, the maximum shear strains at the implant-bone interface in different planes were reduced by about 40%, in the optimized thread, compared with the initial design., Conclusions: The optimized design found in this study is a buttress thread with a fine pitch, but deep thread, which keeps the mechanical stimuli in a safe range to grant an acceptable level of stability., Competing Interests: Declaration of competing interest The authors declare no competing interests., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Primary stability of dental implants is the initial mechanical engagement of the implant with its adjacent bone. Implantation and the subsequent loading may cause mechanical damage in the peripheral bone, which ultimately reduces the stability of the implant. This study aimed at evaluating primary stability of dental implants through applying stepwise compressive displacement-controlled, loading-unloading cycles to obtain overall stiffness and dissipated energy of the bone-implant structure; and quantifying induced plastic strains in surrounding bone using digital volume correlation (DVC) method, through comparing μCT images in different loading steps. To this end, dental implants were inserted into the cylindrical trabecular bones, then the bone-implant structure was undergone step-wise loading-unloading cycles, and μCT images were taken in some particular steps, then comparison was made between undeformed and deformed configurations using DVC to quantify plastic strain within the trabecular bone. Comparing stiffness reduction and dissipated energy values in different loading steps, obtained from the force-displacement curve in each loading step, revealed that the maximum displacement of 0.16 mm can be deemed as a safe threshold above which damages in peri-implant bone started to increase considerably (p < 0.05). In addition, it was found here that peri-implant bone strain linearly increased with decreasing bone-implant stiffness (p < 0.05). Moreover, strain concentration in peri-implant bone region showed that the plastic strain in trabecular bone spread up to a distance of about 2.5 mm away from the implant surface. Research of this kind can be used to optimize the design of dental implants, with the ultimate goal of improving their stability, also to validate in-silico models, e.g., micro-finite element models, which can help gain a deeper understanding of bone-implant construct behavior., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier Ltd. All rights reserved.)

Objectives: The study aimed at discovering the existing differences in lower limb joints' kinematics, and EMG signals of 4 particular muscles of the ankle joint during gait, between normal subjects and patients with bilateral triple arthrodesis., Methods: In this research, a 3D motion analysis system was used and joints' angles were calculated using a MATLAB code, and based on the data collected from markers movements, for patients with bilateral triple arthrodesis and normal subjects. Moreover, the EMG signals of ankle muscles in each subject, and the graphs of mean plus and minus standard deviation of lower limb joint angles and muscles' EMG were calculated by MATLAB., Results: In all patients, an initial ankle eversion and valgus deformity were observed in their knee joints. In addition, for all patients, the maximum knee extension was less than that of the average value of the normal subjects. Furthermore, the results of the electromyography showed that, in all patients, delay occurred in gastrocnemius and soleus muscles in maximum contraction in their EMG signals. Besides, during the early stance phase of gait cycles, the mean value of EMG of peroneus brevis muscle for patients was more than that of normal subjects., Conclusion: Atrophy of four ankle muscles including (soleus, lateral gastrocnemius, tibialis anterior and peroneus brevis), also limitation of joints movement were observed in patients, compared to normal subjects. Based on the results of this work, in order to reduce further musculoskeletal disorders in patients who underwent bilateral triple arthrodesis surgery, there is a serious need to use physiotherapy after the surgery., Competing Interests: None

This study investigated the effects of hydroxyapatite (HA) and hydroxyapatite/titanium (HA/Ti) coatings on osseointegration and bonding strength at the bone-implant interface. The coatings were made using air plasma spray (APS), and three study groups were examined: 1) Uncoated commercial pure titanium (CP-Ti) rods; 2) HA-coated CP-Ti rods, and 3) Composite of 50 %wt HA + 50 %wt Ti coated CP-Ti rods. The rods were implanted into the distal femurs and proximal tibias of fifteen New Zealand white rabbits, and 8 weeks after the implantation, the samples were harvested. The results of pull-out tests showed that the ultimate strength of HA and HA/Ti coatings were significantly greater than the uncoated samples (P &lt; 0.05). Moreover, even though the histological evaluations showed significantly greater osseointegration of HA/Ti composite coatings compared with HA coatings (P &lt; 0.05), nonetheless, the composite of HA/Ti offers no significant increase in the ultimate strength, stiffness, and bonding strength at the bone-implant interface, compared with the HA group (P &gt; 0.05). Thus, in an eight-week study, there was no linear correlation between the osseointegration and the bonding strength at the bone-implant interface. The results of this work may imply that the extent of osseointegration at the bone-implant interface does not necessarily determine the value of the bonding strength at the bone-implant interface. It is speculated that, in a longer-term study, a greater quality of bone formation may occur during osseointegration, between the implant and its adjacent bone, which can lead to a more enhanced bonding strength, compared with the 8-weeks post-surgery follow up., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier Ltd. All rights reserved.)

Although the anterior cruciate ligament (ACL) reconstruction using interference screw is a well-accepted surgical procedure, patients still suffer graft failure in the initial rehabilitation phase. Graft fixation stability of a newly designed anatomical hybrid thread tapered interference screw (AHTTIS) was compared with a conventional standard one (CSIS) by conducting in-vitro mechanical tests. According to the CSIS manufacturer's instruction, eight tapered bone tunnels, matching AHTTIS geometry, and eight straight cylindrical tunnels were drilled in artificial bone blocks. Bovine tendon grafts were fixed using AHTTIS and CSIS in their corresponding bone tunnels. Each graft was subjected to a pre-load, a dynamic cyclic sinusoidal tensile load, and a tensile pullout load. Aggregate graft displacement relative to the bone tunnel under dynamic cyclic load, load corresponding to a 3 mm displacement; load and displacement at yield and ultimate failure of the graft; and graft-bone-screw stiffness resulted from pullout tests were recorded. There were no significant differences between recorded parameters of the two groups, except the graft displacements relative to the bone tunnel at ultimate failure load (8.35 ± 3.03 mm versus 5.28 ± 1.37 mm) and at the yield point (7.73 ± 3.02 mm versus 4.59 ± 1.25 mm) (P < 0.05), which were both significantly greater for the AHTTIS group. Considering all tests were made in the worst-case scenario of fixation of an interference screw, i.e., the employed synthetic bone just mimicked cancellous bone, graft fixation with the AHTTIS is practical. However, in the case of employing high strain rate loads on AHTTIS, further considerations are needed to reduce the side effect of slippage of the graft., (Copyright © 2022 Elsevier Ltd. All rights reserved.)

Performance of the locking compression plate (LCP) is a multifactorial function. The control parameters of plating, such as geometries, material properties, and physical constraints of the LCP components, affect basic functions associated with the bone fixation, including the extent of stress shielding and subsequent bone remodeling, strength and stability of the bone-LCP construct, and performance of secondary bone healing. The main objectives of this research were as follows: (1) to find the appropriate values of control parameters of an LCP construct to achieve the optimized performance throughout bone healing; and (2) to unravel relationships between LCP parameters and the LCP's performance. Different values for the plate/screw modulus of elasticity (E), plate width (W), plate thickness (T), screw diameter (D), bone-plate offset (O), and screw configuration (C), as six control parameters, were considered at five different levels. Taguchi method was adopted to create trial combinations of control parameters and determining the best set of parameters, which can optimize the overall performance of the LCP. All design cases were analyzed using the finite element method. The optimal set of control parameters consisting of 150 GPa, 12 mm, 4 mm, 5.5 mm, 2 mm, and 123,678 were determined for E, W, T, D, O, and C, respectively. Furthermore, ANOVA was used to rank the most influential parameters on each function of the LCP fixation. In the overall performance of the LCP fixation, E, D, T, C, W, and O showed a contribution percentage of 46%, 22%, 10%, 11%, 8%, and 3%, respectively., (© 2021 John Wiley & Sons Ltd.)

This study aimed to explore the effects of drilling rotational speed and feed-rate on the stability of dental implants through in-vivo and ex-vivo experiments. To this end, a total of 16 identical dental implants were inserted in the mandible of four dogs. The osteotomies were made with two drilling rotational speeds, i.e., 800 and 1500 rpm, and two different feed-rates, i.e., 1 and 2 mm/s. Implant stability quotients (ISQs) were recorded immediately after inserting implants and then each week for four subsequent weeks. Then, all animals were euthanized, and a bone sample containing the implants was extracted from each hemi-mandible for the pull-out test. A two-way ANOVA was performed for ISQs, and pull-out strengths (PoS), and the significance level was set to <0.05. The effect of rotational speed and feed-rate, used in this study, on the primary stability quotients was not significant (P > 0.05). Increasing the rotational speed from 800 to 1500 rpm significantly increased both ISQ and PoS values at the end of the 4 th week after the implantation (P = 0.022 and P = 0.001, respectively). Moreover, by decreasing the feed-rate from 2 to 1 mm/s, a significant increase in PoSs of the dental implants was observed four weeks after the implantation (P = 0.019). Results of this study showed that either by increasing drilling rotational speed, here from 800 to 1500 rpm, or by reducing feed-rate, here from 2 to 1 mm/s, the secondary stability would be reinforced. Further investigations are needed to see if and how the conclusions made in this study can be generalized., (Copyright © 2021. Published by Elsevier Ltd.)

Total ankle replacement (TAR) and subtalar joint (STJ) fusion, are popular treatments for ankle osteoarthritis (OA). Short endurance limits the former, and movement disability comes with the latter. It is hypothesized here that fusion of the STJ can improve the longevity of the TAR prosthesis. In this study, a fresh human cadaver's ankle joint underwent TAR surgery, and strain patterns in the vicinity of prosthesis were recorded after the application of axial compressive load on tibia, resembling stance phase of the gait. Then, STJ of the same sample fused (FTAR), and a similar test procedure was pursued. The obtained strains in the FTAR were smaller than those of the TAR (p < .01). Finite element models of the tested samples were also made, and validated by experimental strains. The validated FE models were then employed to find stress distribution on the tibial plateau and prosthesis compartments. FTAR demonstrated more regular stress profiles in bone-prosthesis interface. Also, maximum von Mises stress in the talar component of the FTAR is approximately half of that in the TAR (8 and 15 MPa, respectively). Based on the results of this study, having a more symmetric load distribution on the prosthesis after STJ fusion, longevity of the TAR may likely increase., (© 2021 John Wiley & Sons, Ltd.)

Background: Superior biomechanical performance of tapered interference screws, compared with non-tapered screws, with reference to the anterior cruciate ligament (ACL) reconstruction process, has been reported in the literature. However, the effect of tapered interference screw's body slope on the initial stability of ACL is poorly understood. Thus, the main goal of this study was to investigate the effect of the interference screw's body slope on the initial stability of the reconstructed ACL., Methods: Based on the best screw-bone tunnel diameter ratios in non-tapered screws, two different tapered interference screws were designed and fabricated. The diameters of both screws were equal to bone tunnel diameter in one-third of their length from screw tip, then they were gradually increased by 1mm, in the lower slope (LSTIS), and 2 mm, in the higher slope (HSTIS) screws. To simulate the ACL reconstruction, sixteen soft tissue grafts were fixed, using HSTIS and LSTIS, in synthetic bone blocks. Through applying sub-failure cyclic incremental tensile load, graft-bone-screw construct's stiffness and graft laxity in each cycle, also through applying subsequent step of loading graft to the failure, maximum load to failure, and graft's mode of failure were determined. Accordingly, the performance of the fabricated interference screws was compared with each other., Results: HSTIS provides a greater graft-bone-screw construct stiffness, and a lower graft laxity, compared to LSTIS. Moreover, transverse rupture of graft fibers for LSTIS, and necking of graft in the HSTIS group were the major types of grafts' failure., Conclusions: HSTIS better replicates the intact ACL's behavior, compared to LSTIS, by causing less damage in graft's fibers; reducing graft laxity; and increasing fixation stability. Nonetheless, finding the optimal slope remains as an unknown and can be the subject of future studies.

This study aimed at finding the acceptable range, and the optimal value for the locking compression plate (LCP) thickness (THK), through simulating the osteogenic pathway of bone healing, and by checking bone-plate construct's strength and stability. To attain the goals of this research, a multi-objective approach was adopted, which should trade-off between some conflicting objectives. A finite element model of the long bone-plate construct was made first, and validated against an experimental study. The validated model was then employed to determine the initial strength and stability of the bone-plate construct, for the time right after surgery, for various thicknesses of the LCP. Afterward, coupling with a mechano-regulatory algorithm, the iterative process of bone healing was simulated, and follow up was made for each LCP thickness, over the first 16 post-operative weeks. Results of this study regarding the sequence of tissue evolution inside the fracture gap, showed a similar trend with the existing in-vivo data. For the material and structural properties assigned to the bone-plate construct, in this study, an optimal thickness for the LCP was found to be 4.7 mm, which provides an enduring fixation through secondary healing, whereas for an LCP with a smaller or greater thickness, either bone-implant failure, unstable fixation, impaired fracture consolidation, or primary healing may occur. This result is in agreement with a recent study, that has employed a comprehensive optimization approach to find the optimal thickness.

The distal femur is the predominant site for benign bone tumours and a common site for fracture following tumour removal or cementation. However, the lack of conclusive assessment criterion for post-operative fracture risk and appropriate devices for cement augmentation are serious concerns. Hence, a validated biomechanical tool was developed to assess bone strength, depending on the size and location of artificially created tumorous defects in the distal femora. The mechanics of the bone-cement interface was investigated to determine the main causes of reconstruction failure. Based on quantitative-CT images, non-linear and heterogeneous finite element (FE) models of human cadaveric distal femora with simulated tumourous defects were created and validated using in vitro mechanical tests from 14 cadaveric samples. Statistical analyses demonstrated a strong linear relationship (R 2  = 0.95, slope = 1.12) with no significant difference between bone strengths predicted by in silico analyses and in vitro tests (P = 0.174). FE analyses showed little reduction in bone strength until the defect was 35% or more of epiphyseal volume, and reduction in bone strength was less pronounced for laterally located defects than medial side defects. Moreover, the proximal end of the cortical window and the most interior wall of the bone-cement interface were the most vulnerable sites for reconstruction failure.

The main goal of this study was to investigate the performance of a night-time Providence brace, which alters stress distribution in the growth plates and ultimately result in a reduced Cobb angle, from a biomechanical standpoint, using experimental and in-silico tools. A patient with a mild scoliosis (Cobb angle = 17) was chosen for this study. Applied forces from the Providence brace on the patient's rib cage and pelvis were measured using flexible force pads, and the measured forces were then imported to the generated FE model, and their effects on both curvature and stress distribution were observed. The measured mean forces applied by the brace were 29.4 N, 24.7 N, 22.4 N, and 37.6 N in the posterior pelvis, anterior pelvis, superior thorax, and inferior thorax, respectively, in the supine position. Results of the FE model showed that there is curvature overcorrection, and also Cobb angle was reduced from 17°, in the initial configuration, to 3.4° right after using the brace. The stress distribution, resulted from the FE model, in the patient's growth plate with the brace in the supine position, deviates from that of a scoliotic individual without the brace, and was in favor of reducing the Cobb angle. It was observed that by wearing the night time brace, unbalanced stress distribution on the lumbar vertebrae caused by the scoliotic spine's curvatures, can be somehow compensated. The method developed in this study can be employed to optimize existing scoliosis braces from the biomechanical standpoint., (© 2020 The Authors.)

This study aimed to investigate changes occurred in the stress distribution in the growth plates (GPs) of a trunk with adolescent idiopathic scoliosis (AIS) following unilateral muscle paralysis. We hypothesized that weakening the appropriately chosen muscles on the concave side can decelerate AIS deformity progression. Muscle forces and reaction loads were estimated by an optimization-driven musculoskeletal (MS) model of adolescents with a normal- and an AIS trunk, and then applied on the finite element model of GPs of L1 through L4. Different set patterns of 95% reduction in the strength of the concave-side longissimus thoracis pars thoracic (LGPT), multifidus lumborum (MFL), and LGPT + MFL muscles were performed in the MS models. Results of this study showed that weakening of the concave-side MFL and LGPT muscles rendered a 35% correction in the symptomatic axial rotation of the AIS spine, and a reduction of about 25% in the compressive von Mises stress on the concave side of GPs, respectively, which can decelerate the deformity progression. It was observed that unilateral muscle weakening caused a compensatory activation of the rest of muscles to retain the spine stability. The intradiscal pressures and ratio between the rotations toward either side of the scoliotic spine, found here, matched well with some recent in-vivo investigations. One of the applications of the stability-based MS model of AIS spine with unilaterally weakened muscles presented in this study is to optimize the performance of the currently used braces. To fortify the presented therapeutic approach, experiments should be done on scoliotic animals., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier Ltd. All rights reserved.)

The goal of this study was to investigate two commonly used methods of fixation of distal metaphyseal tibia fractures, plating and nailing as well as the less frequently employed nailing with Poller screws, from a biomechanical perspective. Despite numerous studies, the best method to repair fractures of tibia the remains up for of debate. This study includes an in vitro experimental phase on human cadaveric tibias followed by a finite element analysis. In the experimental phase, under partial weight-bearing axial loading, the axial stiffness of the bone-implant construct and interfragmentary movements for each of the fixation methods, bone-plate, bone-nail, and bone-nail-Poller screw, were measured and compared with each other. Shear interfragmentary movement and stress distribution in the bone-implant construct for the three mentioned fixation methods were also determined from FE models and compared with each other. Results of in vitro experiments, i.e., the exertion of axial loading on the tibia-plate, tibia-nail, and tibia-nail-Poller screw, showed that utilization of tibia-nail and tibia-nail-Poller screw led to a stiffer bone-implant construct, and consequently, lower interfragmentary movement, compared to the tibia-plate construct ( p values for tibia-nail and tibia-nail-Poller screw, and for both axial stiffness and interfragmentary movement, compared to those of tibia-plate construct, were less than 0.05). Numerical analyses showed that nailing produced less undesirable shear interfragmentary movement, compared to the plating, and application of a Poller screw decreased the shear movements, compared to tibia-nail. Furthermore, using the finite element analysis, maximum von Mises stress of adding a screw in tibia-nail, tibia-plate, and tibia-nail-Poller screw, was found to be: 51.5, 78.6, and 60.5 MPa, respectively. The results of this study suggested that from a biomechanical standpoint, nailing both with and without a Poller screw is superior to plating for the treatment of distal tibia fractures.

During dental trauma, periodontal ligament (PDL) contributes to the stability of the tooth-PDL-bone structure. When a dental implant is inserted into the bone, the dental implant-bone construct will be more prone to mechanical damage, caused by impact loading, than the tooth-PDL-bone construct. In spite of the prevalence of such traumas, the behavioral differences between these two constructs have not been well-understood yet. The main goal of this study was to compare the momentum transferred to the tooth-PDL-bone and dental implant-bone constructs under impact loading. First, mechanical impact tests were performed on six canine mandibles of intact ( N = 3) and implanted ( N = 3) specimens using a custom-made drop tower apparatus, from release heights of 1, 2, and 3 cm. Next, computed tomography-based finite element models were developed for both constructs, and the transferred momenta were calculated. The experimental results indicated that, for the release heights of 1, 2, and 3 cm, the linear momenta transferred to the dental implant-bone construct were 33.1, 31.0, and 27.5% greater than those of the tooth-PDL-bone construct, respectively. Moreover, results of finite element simulations were in agreement with those of the experimental tests (error <7.5%). This work tried to elucidate the effects of impact loading on the dental implant-bone and tooth-PDL-bone constructs using both in-vitro tests and validated in-silico simulations. The findings can be employed to modify design of the current generation of dental implants, based on the lessons one can take from the biomechanical behavior of a natural tooth structure., (Copyright © 2020 Karimi Dastgerdi, Rouhi, Dehghan, Farzad-Mohajeri and Barikani.)

Two optimization-driven approaches were employed to develop kinematics-driven (KD) and stability-based kinematics-driven (SKD) musculoskeletal models of an adult thoracolumbar to ascertain the significance of spine stability in holding the upright-standing posture after muscular disuse atrophy. Both models were used to estimate muscle forces of the trunk with intact and unilaterally reduced longissimus thoracis pars thoracic (LGPT) and multifidus lumborum (MFL) muscles strength. A finite element model of the L5-S1 segment of the same kinematics was also developed to compare the joint stresses predicted by the KD and SKD models. Matching well with in vivo data, the SKD model predicted a 15% and 33% reduction in contralateral muscle forces to the 95% debilitated LGPT and MFL muscles, respectively. In contrast, the contralateral muscle force enhancement to the debilitated MFL muscle in the KD model was in contradiction with in vivo data, implying that the KD model is incapable of correctly predicting the muscular disorders. However, the similarity of both models' predictions of intradiscal pressures and intervertebral discs' stresses, which matched well with in vivo data, does indicate the feasibility of the KD model to investigate trunk muscle weakness effects on spinal loads, which could offer additional tools for research in ergonomics. Nonetheless, SKD models can be employed for assessment of contralateral muscle impotence in spinal neuromuscular disorders., (Copyright © 2019 IPEM. Published by Elsevier Ltd. All rights reserved.)

Cement augmentation following benign bone tumor surgery, i.e. curettage and cementation, is recommended in patients at high risk of fracture. Nonetheless, identifying appropriate cases and devices for augmentation remains debatable. Our goal was to develop a validated biomechanical tool to: predict the post-surgery strength of a femoral bone, assess the precision and accuracy of the predicted strength, and discover the mechanisms of reconstruction failure, with the aim of finding a safe biomechanical fixation. Tumor surgery was mimicked in quantitative-CT (QCT) scanned cadaveric human distal femora, and subsequently tested in compression to measure bone strength (F Exp ). Finite element (FE) models considering bone material non-homogeneity and non-linearity were constructed to predict bone strength (F FE ). Analyses of contact, damage, and crack initiation at the bone-cement interface (BCI) were completed to investigate critical failure locations. Results of paired t-tests did not show a significant difference between F Exp and F FE (P > 0.05); linear regression analysis resulted in good correlation between F Exp and F FE (R 2  = 0.94). Evaluation of the models precision using linear regression analysis yielded R 2  = 0.89, with the slope = 1.08 and intercept = -324.16 N. FE analyses showed the initiation of damage and crack and a larger cement debonding area at the proximal end and most interior part of BCI, respectively. Therefore, we speculated that devices that reinforce critical failure locations offer the most biomechanical advantage. The QCT-based FE method proved to be a reliable tool to predict distal femoral strength, identify some causes of reconstruction failure, and assist in a safer selection of fixation devices to reduce post-operative fracture risk., (Copyright © 2019 Elsevier Ltd. All rights reserved.)

Femoral neck fractures represent a relatively uncommon injury in the non-elderly population often resulting from high-energy trauma. Clinical outcome in these patients can be improved by optimizing surgical procedures and selecting appropriate fixation methods. The aim of this study was to develop a numerical fracture model to investigate the influence of critical mechanical factors on the stability of fixation methods for femoral neck fractures. The mechanical stability of fracture fixation was assessed through employing finite element models and simulating progressive consolidation of the fracture for a vertical femoral neck fracture (i.e. Pauwels type III in which the angle between the fracture line and the horizontal plane is greater than 70°). Mechanical performance was compared among three different fixation methods (cannulated screws, dynamic hip screw with de-rotational screw, and proximal femoral locking plate). Axial femoral head displacement varied from 2.3 mm for cannulated screws to 1.12 mm for proximal femoral locking plate, although dynamic hip screw with de-rotational screw indicated a value of 0.94 mm. Considering a consolidated fracture and full weight-bearing load case, average displacements of fracture fragments were obtained of about 1.5, 3 and 70 µm for dynamic hip screw with de-rotational screw, proximal femoral locking plate and cannulated screws methods, respectively. In terms of interfragmentary movements at the fracture site, outcomes of this study demonstrated that, in agreement with our previous experimental research, the dynamic hip screw with de-rotational screw implant is a more effective choice than cannulated screws and proximal femoral locking plate techniques for vertical femoral neck fractures in young patients. Thus, one may conclude that the use of dynamic hip screw with de-rotational screw, particularly during the early stages of bone healing, could provide suitable mechanical environments that facilitate direct bone formation and shorter healing times.

This study aimed at investigating the expression of osteoblast and chondrocyte-related genes in mesenchymal stem cells (MSCs), derived from rabbit adipose tissue, under mechanical vibration. The cells were placed securely on a vibrator's platform and subjected to 300 Hz of sinusoidal vibration, with a maximum amplitude of 10 μm, for 45 min per day, and for 14 consequent days, in the absence of biochemical reagents. The negative control group was placed in the conventional culture medium with no mechanical loading. The expression of osteoblast and chondrocyte-related genes was investigated using real-time polymerase chain reaction (real-time PCR). In addition, F-actin fiber structure and alignment with the help of actin filament fluorescence staining were evaluated, and the level of metabolic activity of MSCs was determined by the methyl thiazolyl tetrazolium assay. The real-time PCR study showed a significant increase of bone gene expression in differentiated cells, compared with MSCs (P < 0.05). On the other hand, the level of chondrocyte gene expression was not remarkable. Applying mechanical vibration enhanced F-actin fiber structure and made them aligned in a specific direction. It was also found that during the differentiation process, the metabolic activity of the cells increased (P < 0.05). The results of this work are in agreement with the well-accepted fact that the MSCs, in the absence of growth factors, are sensitive to low-amplitude, high-frequency vibration. Outcomes of this work can be applied in cell therapy and tissue engineering, when regulation of stem cells is required.

One of the main procedures in intestinal surgery is anastomosis, which is mostly performed by stapling or hand suturing. Due to limitations of these methods, a novel automatic suturing machine was designed and fabricated in this study, equipped with a needle-driving system; a thread control mechanism, and a linear mechanism, which is applicable in intestinal anastomosis by making continuous sutures. The main advantages of the fabricated machine are employing biocompatible suture, from the tissue's adaptation point of view, and making a uniform suturing pattern, independent of surgeon's skill, and thus offering a greater strength than the hand-sutured specimen. In order to evaluate the capability of the fabricated machine and investigate the validity of the hypothesis made in this study, that is, a more uniform suture will result in a greater mechanical strength of the sutured tissue, in vitro tests were performed on human intestine specimens, which were manually sutured by an expert surgeon and by the automatic suturing machine. The tensile tests with an elongation rate of 5 mm/min were done for 90 specimens, in 9 groups with various suturing configurations. The optimum pattern, from the mechanical strength point of view, was found to be the same in both manual and automatic suturing methods, that is, h7 d6 ( h = distance of suture from the edge of the tissue = 7 mm, and d = distance between stitches = 6 mm). It was also shown that the maximum breaking strength, for the best suturing pattern, h7 d6, is significantly greater when the automatic suturing machine was employed, compared with the hand-sutured tissue ( P < .001).

Using a combined musculoskeletal and finite element (FE) approach, this study aimed to evaluate stability-based muscle forces in a spine with adolescent idiopathic scoliosis (AIS) as compared to a normal spine; and subsequently, determine the effects of stress distribution on the growth plates (GPs) of the growing spine. For this purpose a nonlinear 3D FE model of one normal and one scoliotic thoracolumbar spine, consisting of GPs attached to rigid L1 to L4 vertebrae, were developed using computed tomography images coupled with a growth modulation using the Stokes' model. Corresponding well with recent in-vivo and in-vitro studies, results of the models predicted intradiscal pressures at the L3-L4 and L4-L5 levels of 0.32 and 0.38 MPa in the normal spine and 0.30 and 0.36 MPa in the scoliotic spine, respectively; and hydrostatic and octahedral shear stresses on the apical GP of 0.11 and 0.06 MPa, respectively. The reaction moments in the scoliotic model resulted in higher compression on the posteroconcave side of the GPs, which led to deformity progression as predicted by the Hueter-Volkmann theory. Moreover, the augmented baseline growth in the Stokes' model magnified both the scoliotic spine height and Cobb angle growth rates. The presented stability-based approach can be used to predict the performance of rehabilitation strategies in the clinical management of AIS., (Copyright © 2019. Published by Elsevier Ltd.)

The main goal of this work was to investigate the effects of implants coatings' mechanical properties and morphology on the osseointegration. In order to produce different mechanical properties of coatings, two thermal spray techniques, high velocity oxy-fuel (HVOF) and air plasma spray (APS) were employed. Titanium pins were coated and implanted into the distal femurs and proximal tibias of fifteen New Zealand white rabbits, equally distributed in three study groups, and a total of 20 pins implanted in each group. Eight weeks after insertion, the rabbits were euthanized and the femur samples were taken out for biomechanical tests and tibia samples for histological evaluations of osseointegration. Scanning electron microscopy results showed enhanced density and a better morphology of HVOF coatings, compared to APS samples, and X-ray diffraction characterized an enhanced crystallinity of HVOF coatings. Nanoindentation tests revealed greater hardness and elastic modulus of HVOF coatings, whereas greater tensile residual stress and more pronounced creep was observed for APS coatings. Neither in biomechanical tests, nor in the histological analyses, a significant difference was observed between HVOF and APS coated samples (p > 0.05, and p > 0.05, respectively). The lack of significant difference between the HVOF and APS coated implants' osseointegration rejected our hypothesis to have a more enhanced osseointegration due to a better morphology, as well as stronger mechanical properties of HA coatings. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2679-2691, 2018., (© 2018 Wiley Periodicals, Inc.)

How the distance of sutures from the edge of tissue and the horizontal distance between stitches affect the mechanical strength of anastomosis is investigated. In this study, 180 bovine intestines were used to investigate the optimum pattern in 18 groups by considering a 4, 6, and 8 mm horizontal distance between stitches, and a 3, 5, and 7 mm distance from the edge of tissue with 3-0 Silk and 3-0 PDS sutures to maximize the strength of anastomosis (10 specimens in each group). Also, 80 specimens were used to investigate the maximum effective distance of sutures from the edge of tissue in eight groups of: 3, 5, 7, and 10 mm distance from the edge, with the same type of sutures. Tensile tests with an elongation rate of 5 mm/min were performed for all the groups. Based on the results, the pattern of 7-6 (distance from the edge-distance between stitches) for both 3-0 Silk and 3-0 PDS, 5-6 and 7-4 for 3-0 Silk, and 5-6 and 7-4 for 3-0 PDS can be considered as the best options among 18 different combinations. It was also found that increasing the distance from the edge from 7 mm to 10 mm does not cause a significant difference in mechanical strength. Results can help surgeons to improve the intestinal anastomosis and employ it as an input for automatic suturing devices.

There are many unanswered questions about giant cell tumor (GCT) treatment and not enough attention is paid to the biomechanics of the current treatment methods. Treatment methods have not changed much, and the best method remains controversial to some degree, due to the lack of adequate clinical and biomechanical investigations. Biomechanical tests, including in vitro mechanical experiments combined with finite element analysis, are very helpful in assessing the efficiency of the surgical methods employed and in determining the optimal method of surgery. Tests can be tailored to meet a patient's needs, while limiting postoperative complications. One of the complications, following tumor surgery, is the frequency of postoperative fractures. In order to prevent postoperative fractures, defect reconstruction is recommended. The reconstruction usually consists of defect infilling with bone cement, and in the case of large defects cement augmentation is employed. Whether cement augmentation is essential and offers enough mechanical strength and what is the best fixation device for cement augmentation are areas of debate. In this article, the biomechanical studies comparing different methods of tumor surgery and cement augmentation, highlighting the areas needing more attention to advance GCT treatment, are critically reviewed. Based on our review, we recommend a biomechanical criterion for the essence of defect reconstruction, which must include patient specific factors, in addition to the tumor geometrical properties., Competing Interests: Compliance with ethical standardsThe authors declare that they have no competing interests.

Background: Vertical femoral neck fractures in the youth could be happened in high-energy accidents, and because of dominant shearing forces, this fracture is considered as a troublesome injury with a controversy regarding selection of the best fixation method., Objective: The long term goal of this quasi-experimental study was to find the more stable fixation method among cannulated screws (CSs), proximal femoral locking plate (PFLP), and dynamic hip screw with derotational screw (DHS+DS) for this kind of fracture., Methods: Twelve fresh-frozen cadaveric femurs were assigned to three groups that were matched for mean bone mineral density and stiffness of intact bone. Vertical fractures were artificially mimicked in the specimens and fixed using three different implants, i.e. CSs, PFLP, and DHS+DS. Then, the samples were tested under incremental, cyclic, and failure loading phases., Results: The differences in all biomechanical parameters were statistically significant among tested groups (p<0.05). All biomechanical parameters for the DHS+DS method of fixation are significantly different from those corresponding to CSs (p<0.05). There were no significant differences in failure load and failure energy between the PFLP and CSs techniques (p>0.05). Also, there were no significant differences in relative stiffness and femoral head displacement between the PFLP and DHS+DS groups (p>0.05)., Conclusions: Based on the clinical assumption that restricted weight-bearing regimen is recommended in the postoperative rehabilitation protocol, the results of this study suggest that the priority order of selection for the stable fixation implant of vertical femoral neck fracture in young patients is DHS+DS, then PFLP, and finally CSs.

Surgical treatment of distal metaphyseal fractures remains problematic, and whilst both intramedullary nailing and bone plate fixation are known as the acceptable methods for the internal fixation of this kind of fractures, neither technique demonstrated satisfactory clinical outcomes. In this research, a finite element based investigation was made to compare these two fixation techniques for the fixation of distal tibia fractures from the biomechanics point of view. For this purpose, a 3mm transverse fracture gap was created at the distal metaphyseal region of tibia and fixed by use of either a nail or a plate. The von Mises stress, interfragmentary movements, and the production of different tissue phenotypes at the fracture site were calculated. Results of this study showed that plating offers more advantageous biomechanical conditions at the fracture site, in which it provides sufficient amount of axial interfragmentary movement and considerable amount of cartilage production, while intramedullary nailing restricts axial movements but causes high magnitude of shear movements. However, nailing is superior to plating from the mechanical point of view and provides earlier weight bearing. In addition, it was shown that by using composite materials, biomechanical behavior of both fixation techniques will be improved through decreasing risk of failure and promoting cartilaginous tissue production., (Copyright © 2015 Elsevier Ltd. All rights reserved.)

Femoral neck fractures in young patients are usually caused by a high-energy trauma, which results in a perpendicular fracture. Although efforts are focused on preserving the femoral head in young patients, vertical femoral neck fracture is a problematic orthopedic injury due to the domination of shear forces. Due to controversy regarding which fixation method is the best choice, the purpose of this study was to find the most stable fixation method for this kind of fracture. This study includes experimental testing on cadaveric bone samples and finite element analysis (FEA) for three fracture fixation techniques, namely cannulated screws (CSs), dynamic hip screw with derotational screw (DHS + DS), and proximal femoral locking plate (PFLP). Experimental results of bone-implant stiffness, average femoral head displacement, failure load, failure energy, and relative position of the fractured fragments indicate that DHS + DS offers the strongest structure for stabilizing a vertical femoral neck fracture. Experimental data and FEA results both indicate that under static loading, the DHS + DS method of fixation produces the lowest femoral head displacement and interfragmentary movement, followed by PFLP and then CSs. The results of this research suggest that, based on the clinical assumption that a restricted weight-bearing regimen is recommended in the postoperative rehabilitation protocol, the DHS + DS method of fixation is a better choice compared to CSs and PFLP for a vertical femoral neck fracture fixation in young adults.

Lower-back injury from snow shovelling may be related to excessive joint loading. Bent-shaft snow shovels are commonly available for purchase; however, their influence on lower back-joint loading is currently not known. Therefore, the purpose of this study was to compare L5/S1 extension angular impulses between a bent-shaft and a standard straight-shaft snow shovel. Eight healthy subjects participated in this study. Each completed a simulated snow-lifting task in a biomechanics laboratory with each shovel design. A standard motion analysis procedure was used to determine L5/S1 angular impulses during each trial, as well as peak L5/S1 extension moments and peak upper body flexion angle. Paired-samples t-tests (α = 0.05) were used to compare variables between shovel designs. Correlation was used to determine the relationship between peak flexion and peak moments. Results of this study show that the bent-shaft snow shovel reduced L5/S1 extension angular impulses by 16.5% (p = 0.022), decreased peak moments by 11.8% (p = 0.044), and peak flexion by 13.0% (p = 0.002) compared to the straight-shaft shovel. Peak L5/S1 extension moment magnitude was correlated with peak upper body flexion angle (r = 0.70). Based on these results, it is concluded that the bent-shaft snow shovel can likely reduce lower-back joint loading during snow shovelling, and thus may have a role in snow shovelling injury prevention., (Copyright © 2013 Elsevier Ltd and The Ergonomics Society. All rights reserved.)

The central tenet of this study was to develop, validate and apply various individualised 3D musculoskeletal models of the human body for application to single-leg landings over increasing vertical heights and horizontal distances. While contributing to an understanding of whether gender differences explain the higher rate of non-contact anterior cruciate ligament (ACL) injuries among females, this study also correlated various musculoskeletal variables significantly impacted by gender, height and/or distance and their interactions with two ACL injury-risk predictor variables; peak vertical ground reaction force (VGRF) and peak proximal tibia anterior shear force (PTASF). Kinematic, kinetic and electromyography data of three male and three female subjects were measured. Results revealed no significant gender differences in the musculoskeletal variables tested except peak VGRF (p = 0.039) and hip axial compressive force (p = 0.032). The quadriceps and the gastrocnemius muscle forces had significant correlations with peak PTASF (r = 0.85, p < 0.05 and r = - 0.88, p < 0.05, respectively). Furthermore, hamstring muscle force was significantly correlated with peak VGRF (r = - 0.90, p < 0.05). The ankle flexion angle was significantly correlated with peak PTASF (r = - 0.82, p < 0.05). Our findings indicate that compared to males, females did not exhibit significantly different muscle forces, or ankle, knee and hip flexion angles during single-leg landings that would explain the gender bias in non-contact ACL injury rate. Our results also suggest that higher quadriceps muscle force increases the risk, while higher hamstring and gastrocnemius muscle forces as well as ankle flexion angle reduce the risk of non-contact ACL injury.

Purpose: This study identified kinematic and knee energetic variables that reduce the risk of non-contact anterior cruciate ligament (ACL) injury during single-leg landings from increasing vertical heights and horizontal distances., Methods: Nine subjects performed single-leg landings from takeoff platforms with vertical heights of 20, 40, and 60 cm onto a force plate. Subjects also performed single-leg landings from a 40 cm high takeoff platform placed at horizontal distances of 30, 50 and 70 cm from a force plate. Kinematic and kinetic data were measured., Results: Vertical height had a significant and positive effect on peak vertical ground reaction force (VGRF) (p<0.001), peak posterior ground reaction force (PGRF) (p=0.004), knee flexion angle (p=0.0043), trunk flexion angle (p=0.03), knee power (p<0.001) and knee work (p<0.001). There was also a significant and positive effect of horizontal distance on peak PGRF (p<0.001), ankle plantar flexion angle (p=0.008), hip flexion angle (p=0.007), and trunk flexion angle (p=0.001). At increasing vertical height, peak VGRF was significantly correlated to ankle plantar flexion and knee flexion angles (r=-0.77, p=0.02 and r=-0.78, p=0.01, respectively). At increasing horizontal distance, peak PGRF was significantly correlated to ankle plantar flexion angle, knee power and knee work (r=-0.85, p=0.003; r=0.67, p=0.04; and r=0.73, p=0.02, respectively)., Clinical Relevance: A better understanding of the risk factors to non-contact ACL injury during single-leg landings from increasing vertical heights and horizontal distances can aid in the design of injury prevention regimen., (Copyright © 2012 Elsevier B.V. All rights reserved.)

Using finite element analysis, a parametric study was developed to compare stress and strain energy density (SED), in order to determine which stimuli might be better for predicting stress shielding in bone-screw models. Defined stimuli transfer parameters demonstrated that stress and SED (strong candidates for initiating the bone remodeling process) are transferred distinctively between an implant and bone. While small diameter angled threads increased transfer of both stimuli, reducing the screw's elastic modulus resulted in an increased transfer of stress; and unexpected decrease in SED, indicating that SED should be carefully examined in the context of future bone-screw models., (© 2013 Elsevier Ltd. All rights reserved.)

Background: The aim of this case study was to identify the effect of a powered stance control knee ankle foot orthosis on the kinematics and temporospatial parameters of walking by a person with poliomyelitis when compared to a knee ankle foot orthosis., Case Description and Methods: A knee ankle foot orthosis was initially manufactured by incorporating drop lock knee joints and custom molded ankle foot orthoses and fitted to a person with poliomyelitis. The orthosis was then adapted by adding electrically activated powered knee joints to provide knee extension torque during stance and also flexion torque in swing phase. Lower limb kinematic and kinetic data plus data for temporospatial parameters were acquired from three test walks using each orthosis., Findings and Outcomes: Walking speed, step length, and vertical and horizontal displacement of the pelvis decreased when walking with the powered stance control knee ankle foot orthosis compared to the knee ankle foot orthosis. When using the powered stance control knee ankle foot orthosis, the knee flexion achieved during swing and also the overall pattern of walking more closely matched that of normal human walking. The reduced walking speed may have caused the smaller compensatory motions detected when the powered stance control knee ankle foot orthosis was used., Conclusion: The new powered SCKAFO facilitated controlled knee flexion and extension during ambulation for a volunteer poliomyelitis person.

There is a lack of studies investigating gender differences in whole-body kinematics during single-leg landings from increasing vertical heights and horizontal distances. This study determined the main effects and interactions of gender, vertical height, and horizontal distance on whole-body joint kinematics during single-leg landings, and established whether these findings could explain the gender disparity in non-contact anterior cruciate ligament (ACL) injury rate. Recreationally active males (n=6) and females (n=6) performed single-leg landings from a takeoff deck of vertical height of 20, 40, and 60 cm placed at a horizontal distance of 30, 50 and 70 cm from the edge of a force platform, while 3D kinematics and kinetics were simultaneously measured. It was determined that peak vertical ground reaction force (VGRF) and the ankle flexion angle exhibited significant gender differences (p=0.028, partial η(2)=0.40 and p=0.035, partial η(2)=0.37, respectively). Peak VGRF was significantly correlated to the ankle flexion angle (r= -0.59, p=0.04), hip flexion angle (r= -0.74, p=0.006), and trunk flexion angle (r= -0.59, p=0.045). Peak posterior ground reaction force (PGRF) was significantly correlated to the ankle flexion angle (r= -0.56, p=0.035), while peak knee abduction moment was significantly correlated to the knee flexion angle (r= -0.64, p=0.03). Rearfoot landings may explain the higher ACL injury rate among females. Higher plantar-flexed ankle, hip, and trunk flexion angles were associated with lower peak ground reaction forces, while higher knee flexion angle was associated with lower peak knee abduction moment, and these kinematics implicate reduced risk of non-contact ACL injury.

Background: Chitosan compounds have been shown to be suitable bone replacement materials. To evaluate the accelerating effects of chitosan on the bone regeneration process and assessing its histopathological adverse effects, we conducted this study on rat tibias., Materials and Methods: In a laboratory experimental study, micro-drilled bone defects were created in the upper tibia of each leg in 15 adult male rats. The defect in the right leg, filled by the chitosan powder, was compared with the untreated defect in the left leg in each rat at 1, 2, and 4 weeks after surgery. Bone repair and inflammation in each specimen was blindly graded by a pathologist. Reaction to the foreign body and the amount of the remaining chitosan were studied in chitosan-treated specimens at the three stages of the study., Results: Bone repair was significantly faster in the chitosan group, 1 week (P = 0.01) and 4 weeks (P = 0.038) after surgery, while the difference was not significant at the 2-week stage (P = 0.197) between chitosan and control groups. Chitosan-induced inflammation was not significant in any stage of the study. Reaction to the foreign body was seen in one case at 2 weeks and one case at 4 weeks postoperation., Conclusion: Chitosan significantly accelerated the bone regeneration process in rat tibias. Regarding its biocompatibility and osteoinductivity, it can be studied as a biomaterial in human bone healing.