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1. Antimalarial artesunate–mefloquine versus praziquantel in African children with schistosomiasis: an open-label, randomized controlled trial

Author

Bottieau, Emmanuel, Mbow, Moustapha, Brosius, Isabel, Roucher, Clémentine, Gueye, Cheikh Tidiane, Mbodj, Ousmane Thiam, Faye, Babacar Thiendella, De Hondt, Annelies, Smekens, Bart, Arango, Diana, Burm, Christophe, Tsoumanis, Achilleas, Paredis, Linda, Van Herrewege, Yven, Potters, Idzi, Richter, Joachim, Rosanas-Urgell, Anna, Cissé, Badara, Mboup, Souleymane, and Polman, Katja

Published
2024
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3. Development of tuberculosis treatment decision algorithms in children below 5 years hospitalised with severe acute malnutrition in Zambia and Uganda: a prospective diagnostic cohort study

Author

Marcy, Olivier, Serre, Angeline, Badrichani, Anne, Razafimanantsoa, Manoa, Poublan, Julien, Vessière, Aurélia, Roucher, Clémentine, Occelli, Estelle, Beuscart, Aurélie, Charpin, Aurélie, Habiyambere, Gemma, Mesnier, Salomé, Balestre, Eric, Koskas, Nicolas, D'Elbée, Marc, Font, Hélène, Ton Nu Nguyet, Minh Huyen, Bonnet, Maryline, Lounnas, Manon, Espérou, Hélène, Couffin-Cadiergues, Sandrine, Kuppers, Alexis, Hamze, Benjamin, Wobudeya, Eric, Businge, Gerald Bright, Namulinda, Faith, Sserunjogi, Robert, Nassozi, Rashidah, Barungi, Charlotte, Hellen, Aanyu, Doreen, Muwonge, Kagoya, Eva, Aciparu, Serene, Sophia, Chemutai, Ntambi, Samuel, Wasswa, Amir, Nangozi, Juliet, Chabala, Chishala, Mulenga, Veronica, Shankalala, Perfect, Hambulo, Chimuka, Kapotwe, Vincent, Ngambi, Marjory, Kasakwa, Kunda, Kanyama, Mirriam, Chirwa, Uzima, Chifunda, Kapula, Mundundu, Gae, Zulu, Susan, Nawakwi, Grace, Siasulingana, Teddy, Himwaze, Diana Attan, Chilonga, Jessy, Chimbini, Maria, Chilanga, Mutinta, Chola, Daniel, Mwango, Eustace, Nduna, Bwendo, Inambao, Muleya, Pumbwe, Mwamba, Mwambazi, Mwate, Halende, Barbara, Mumba, Wyclef, Mankunshe, Endreen, Silavwe, Maureen, Chakopo, Moses, Moono, Roy, Chungu, Chalilwe, Zimba, Kevin, Kapasa, Monica, Zyambo, Khozya, Babirekere, Esther, Businge, Gerald, Kapula, Chifunda, and Graham, Stephen

Published
2024
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4. Effect of systematic tuberculosis detection on mortality in young children with severe pneumonia in countries with high incidence of tuberculosis: a stepped-wedge cluster-randomised trial

Author

Marcy, Olivier, Serre, Angeline, Badrichani, Anne, Razafimanantsoa, Manoa, Poublan, Julien, Vessière, Aurélia, Roucher, Clémentine, Occelli, Estelle, Beuscart, Aurélie, Charpin, Aurélie, Habiyambere, Gemma, Mesnier, Salomé, Balestre, Eric, Bhatta, Bandana, Maillard, Anne-Laure, Orne-Gliemann, Joanna, Baillet, Emmanuelle, Koskas, Nicolas, D'Elbée, Marc, Gabillard, Delphine, Font, Hélène, Huyen, Minh, Bonnet, Maryline, Lounnas, Manon, Espérou, Hélène, Couffin-Cadiergues, Sandrine, Kuppers, Alexis, Hamze, Benjamin, BORAND, Laurence, de LAUZANNE, Agathe, DIM, Bunnet, Keang, Chanthy, PRING, Long, YIN, Song, SARITH, Channimol, PHAN, Chanvirak, NHEUONG, Sovann, LY, Socheat, KAING, Sanary, SRENG, Vouchleang, LUN, Elen, SAY, Leakhena, SUOM, Sophea, FERHY, Romyka, SO, Dina, BORN, Sorunna, PAL, Sophea, NANG, Boraneath, MAO, Tan Eang, KIM, Ang, Srey, Viso, Kan, Piseth, Hout, leakhena, Ith, Samnang, Oum, Sophany, Sau, Sokunvadhana, Ho, Kim Heang, Kith, Daronic, Nuch, Nathara, Horm, Chhun Leang, Sophon, Cheameas, Roeungdeth, Bosba, MENG, Chhay, RITH, Ravin, PHY, Samnang, SOR, Chanchetra, SAO, Voleak, KHAT, Sophea, MAK, Bunthoeun, UY, Angkeaborin, KHAY, Sreyny, SOM, Kimsan, HACH, rongvirak, SOK, Hay, KUON, Sotheavy, HENG, Synatt, SENG, Amara, NIM, Sopheak, PAN, Reach, KIM, Srean, SREY LEAP, Keo, NET, Bormey, NOUN, Viccheka, LAY, Daven, MANY, Chhaing, Seng, Socheata, Ly, Vuthy, So, Saran, Oun, Sovutthik, CHEY, Sopheap, CHHEA, Rattany, BAONG, Lydeth, THOUNG, Vanna, KHEANG, Chanrithea, BY, Borady, Nguon, Vathanak, MEACH, Eksophea, Tek, Sopheak, Ngeav, Sina, Lun, Tetra, HEM, Deth, CHUT, Nayreang, SARIK, Setha, NANG, Hgekkoung, MEACH, Mengnean, SRENG, Sopal, SAR, Dara, KIN, Rathana, ROS, Phoran, DORN, Chenda, KAK, Chansy, Sambath, Srey Leak, Son, Leakhena, Bin, Linda, Pengong, Eangnay, Pol, Sokha, Khutsorn, Samnang, Seang, Sorsophea, Soun, Virak, Vong, Vuthy, Khoeung, Chandara, Um, Panha, Bou, Sokunthea, Song Pich, Sarin, Nim, Puthy, Khat, Sopheak, Ban Si, Nuon, Ream, Sovannodom, Ing, Sim, Chann, Phanith, Ngeth, Samrith, Sun, Marina, Chhoeung, Sokea, Sean, Soeun, Prak, Ratanak, Taguebue, Jean-Voisin, Kwedi Nolna, Sylvie, Amboua Schouame Onambele, Audrey, Hycenth, Numfor, Melingui, Bernard, Nkembe Medounmga, Angeline, Hougnang Tatmi, Luciole, Etemgoua, Nathalie, Kouesso, Vanessa, Bugin, Jean, Nzedjom, Celestine, Ngoya, Roger, Eyike, Jules, Loudjom, Elyse, Lonsti, Roger, Dang, Ladi, Bintar, Edward, Njayong, Chantal, Ngonsoa O, Cinthia, Ndzeukap, Isabelle, Dzoyem, Pascaline, Dzokou, Clémentine, Dindo, Berthe, Moh, Raoul, Komena, Eric Auguste, Aka Bony, Roger, Kouadio, Christian, Danho, Serge, Goli, Melissa, Folquet, Madeleine, Itchy, Max Valère, Sidibé, Abdel, Cissé, Lancina, Ouattara, Joseph, Konaté, Mamadou, Amon-Tanoh Dick, Flore, Cardena, Melissa, Adonis-Koffi, Laurence, Eugenie, Djabia, Kouamé, Ferdinand, Menan, Hervé, Inwoley, André, Ouassa, Timothée, Nguessan, Marcelle Sandrine, Khosa, Celso, Cumbe, Saniata, Manhiça, Emelva, Zitha, Alcina, Chiúle, Valter, Muxanga, Eva, Gune, Irene, Lima, Yara, Ribeiro, Jorge, Mavale, Sandra, Chilundo, Josina, Maxanguana, Felismina, Morais, Natália, Manhiça, Julieta, Give, Josefina, Atumane, Jafito, Lucas, Gelson, Thai, Arsénio, Chave, Adélio, Rego, Dalila, Guambe, Lúcia, Issa, Faiaz, Carneiro, Rosa, Pene, Neusa, Florindo, Natércia, Machel, Dália, Cumbane, Cecília, Mendes, Helena, Kitungwa, Mule, Muianga, Valdo, Tamele, Humberto, Sulude, Adelino, Mabota, Roda, Comandante, Herquéria, Massangaie, Abelardo, Wobudeya, Eric, Businge, Gerald Bright, Namulinda, Faith, Sserunjogi, Robert, Nassozi, Rashidah, Barungi, Charlotte, Aanyu, Hellen, Muwonge, Doreen, Kagoya, Eva, Aciparu, Serene, Chemutai, Sophia, Ntambi, Samuel, Wasswa, Amir, Nangozi, Juliet, Tagoola, Abner, Mbekeka, Prossy, Kenneth, Sajja, Lubega, John Paul, Nassali, Aidah, Tagobera, Jessica, Agwang, Christine, Kalembe, Florence, Ajambo, Annet, Aguti, Elizabeth, Kasibante, Samuel, Matende, Henry, Odongo, Israel Owen, Mwanga Amumpaire, Juliet, Natukunda, Naome, Ngabirano, Gertrude, Kakwenza, Paul, Nuwamanya, Simpson, Nyangoma, Miria, Nabbuto, Jane, Abok, Florence, Arinaitwe, Rinah, Birungi, Diana, Mwesigwa, Evans, Atwine, Daniel, Mbega, Hassan, Orikiriza, Patrick, Taremwa, Ivan, Turyashemererwa, Esther, Derrick, Hope, Nyehangane, Dan, Kaitano, Rodney, Logoose, Susan, Businge, Steven, Ntambi, Charles, Mugabi, Jerome, Mzee, John, Besigye, Julius, Kanzira, Saul, Turyatemba, Phionah, Twebaze, Florence, Chabala, Chishala, Mulenga, Veronica, Shankalala, Perfect, Hambulo, Chimuka, Kapotwe, Vincent, Ngambi, Marjory, Kasakwa, Kunda, Chirwa, Uzima, Kapula, Chifunda, Zulu, Susan, Nawakwi, Grace, Siasulingana, Teddy, Chilonga, Jessy, Chimbini, Maria, Chilanga, Mutinta, Nduna, Bwendo, Inambao, Muleya, Mwambazi, Mwate, Halende, Barbra, Mumba, Wyclef, Mankunshe, Endreen, Silavwe, Maureen, Chakopo, Moses, Moono, Roy, Mwanga-Amumpaire, Juliet, De Lauzanne, Agathe, Dim, Bunnet, Tiogouo Ngouana, Emeline, Folquet Amorrissani, Madeleine, Cisse, Lassina, Amon Tanoh Dick, Flore, Komena, Eric A, Businge, Gerald, Kim, Ang, Kheang, Chanrithea, Maleche-Obimbo, Elizabeth, Seddon, James A, Mao, Tan Eang, Graham, Stephen M, Delacourt, Christophe, and Borand, Laurence

Published
2023
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5. Profile of Children with Undernutrition Admitted in Two Secondary-Level Hospitals in Maputo City, Mozambique.

Author

Cossa-Moiane, Idalécia, Roucher, Clémentine, Campos-Ponce, Maiza, Doak, Colleen, Bauhofer, Adilson, Chissaque, Assucênio, Prista, António, de Deus, Nilsa, and Polman, Katja

Abstract

Mozambique has one of the highest child undernutrition rates in Sub-Saharan Africa. The aim of this study was to characterize the profile of children from 1 to 14 years old hospitalized for undernutrition and to explore associated risk factors. Clinical, demographic, socioeconomic, and environmental data were collected. Anthropometric measurements and stool samples were collected from a child and their caretaker. The wealth index was determined using Principal Components Analysis. A total of 449 children and their caretakers were enrolled. The children had a median age of 1.0 year [IQR: 1.0–2.0], and 53.9% (242/449) were male. Most were admitted with severe undernutrition (35.7%, 159/449 kwashiorkor and 82.0%, 368/449 with −3SD Z-score indexes). The most common co-morbidities were HIV (30.0%, 120/400), diarrhea (20.0%; 80/400), and anemia (12.5%; 50/400). Among the caretakers, 9.5% (39/409) were underweight, 10.1% (40/397) were overweight, and 14.1% (56/397) were obese. Intestinal parasites were found in 24.8% (90/363) children and in 38.5% (77/200) caretakers. The majority of children (60.7%, 85/140) came from low- to middle-wealth households. Most were severely undernourished, suggesting that they seek medical care too late. The finding of overweight/obese caretakers in combination with undernourished children confirms that Mozambique is facing a double burden of malnutrition. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Effect of systematic tuberculosis detection on mortality in young children with severe pneumonia in countries with high incidence of tuberculosis: a stepped-wedge cluster-randomised trial

Author

Marcy, Olivier, primary, Wobudeya, Eric, additional, Font, Hélène, additional, Vessière, Aurélia, additional, Chabala, Chishala, additional, Khosa, Celso, additional, Taguebue, Jean-Voisin, additional, Moh, Raoul, additional, Mwanga-Amumpaire, Juliet, additional, Lounnas, Manon, additional, Mulenga, Veronica, additional, Mavale, Sandra, additional, Chilundo, Josina, additional, Rego, Dalila, additional, Nduna, Bwendo, additional, Shankalala, Perfect, additional, Chirwa, Uzima, additional, De Lauzanne, Agathe, additional, Dim, Bunnet, additional, Tiogouo Ngouana, Emeline, additional, Folquet Amorrissani, Madeleine, additional, Cisse, Lassina, additional, Amon Tanoh Dick, Flore, additional, Komena, Eric A, additional, Kwedi Nolna, Sylvie, additional, Businge, Gerald, additional, Natukunda, Naome, additional, Cumbe, Saniata, additional, Mbekeka, Prossy, additional, Kim, Ang, additional, Kheang, Chanrithea, additional, Pol, Sokha, additional, Maleche-Obimbo, Elizabeth, additional, Seddon, James A, additional, Mao, Tan Eang, additional, Graham, Stephen M, additional, Delacourt, Christophe, additional, Borand, Laurence, additional, Bonnet, Maryline, additional, Marcy, Olivier, additional, Serre, Angeline, additional, Badrichani, Anne, additional, Razafimanantsoa, Manoa, additional, Poublan, Julien, additional, Roucher, Clémentine, additional, Occelli, Estelle, additional, Beuscart, Aurélie, additional, Charpin, Aurélie, additional, Habiyambere, Gemma, additional, Mesnier, Salomé, additional, Balestre, Eric, additional, Bhatta, Bandana, additional, Maillard, Anne-Laure, additional, Orne-Gliemann, Joanna, additional, Baillet, Emmanuelle, additional, Koskas, Nicolas, additional, D'Elbée, Marc, additional, Gabillard, Delphine, additional, Huyen, Minh, additional, Espérou, Hélène, additional, Couffin-Cadiergues, Sandrine, additional, Kuppers, Alexis, additional, Hamze, Benjamin, additional, BORAND, Laurence, additional, de LAUZANNE, Agathe, additional, DIM, Bunnet, additional, Keang, Chanthy, additional, PRING, Long, additional, YIN, Song, additional, SARITH, Channimol, additional, PHAN, Chanvirak, additional, NHEUONG, Sovann, additional, LY, Socheat, additional, KAING, Sanary, additional, SRENG, Vouchleang, additional, LUN, Elen, additional, SAY, Leakhena, additional, SUOM, Sophea, additional, FERHY, Romyka, additional, SO, Dina, additional, BORN, Sorunna, additional, PAL, Sophea, additional, NANG, Boraneath, additional, MAO, Tan Eang, additional, KIM, Ang, additional, Srey, Viso, additional, Kan, Piseth, additional, Hout, leakhena, additional, Ith, Samnang, additional, Oum, Sophany, additional, Sau, Sokunvadhana, additional, Ho, Kim Heang, additional, Kith, Daronic, additional, Nuch, Nathara, additional, Horm, Chhun Leang, additional, Sophon, Cheameas, additional, Roeungdeth, Bosba, additional, MENG, Chhay, additional, RITH, Ravin, additional, PHY, Samnang, additional, SOR, Chanchetra, additional, SAO, Voleak, additional, KHAT, Sophea, additional, MAK, Bunthoeun, additional, UY, Angkeaborin, additional, KHAY, Sreyny, additional, SOM, Kimsan, additional, HACH, rongvirak, additional, SOK, Hay, additional, KUON, Sotheavy, additional, HENG, Synatt, additional, SENG, Amara, additional, NIM, Sopheak, additional, PAN, Reach, additional, KIM, Srean, additional, SREY LEAP, Keo, additional, NET, Bormey, additional, NOUN, Viccheka, additional, LAY, Daven, additional, MANY, Chhaing, additional, Seng, Socheata, additional, Ly, Vuthy, additional, So, Saran, additional, Oun, Sovutthik, additional, CHEY, Sopheap, additional, CHHEA, Rattany, additional, BAONG, Lydeth, additional, THOUNG, Vanna, additional, KHEANG, Chanrithea, additional, BY, Borady, additional, Nguon, Vathanak, additional, MEACH, Eksophea, additional, Tek, Sopheak, additional, Ngeav, Sina, additional, Lun, Tetra, additional, HEM, Deth, additional, CHUT, Nayreang, additional, SARIK, Setha, additional, NANG, Hgekkoung, additional, MEACH, Mengnean, additional, SRENG, Sopal, additional, SAR, Dara, additional, KIN, Rathana, additional, ROS, Phoran, additional, DORN, Chenda, additional, KAK, Chansy, additional, Sambath, Srey Leak, additional, Son, Leakhena, additional, Bin, Linda, additional, Pengong, Eangnay, additional, Khutsorn, Samnang, additional, Seang, Sorsophea, additional, Soun, Virak, additional, Vong, Vuthy, additional, Khoeung, Chandara, additional, Um, Panha, additional, Bou, Sokunthea, additional, Song Pich, Sarin, additional, Nim, Puthy, additional, Khat, Sopheak, additional, Ban Si, Nuon, additional, Ream, Sovannodom, additional, Ing, Sim, additional, Chann, Phanith, additional, Ngeth, Samrith, additional, Sun, Marina, additional, Chhoeung, Sokea, additional, Sean, Soeun, additional, Prak, Ratanak, additional, Amboua Schouame Onambele, Audrey, additional, Hycenth, Numfor, additional, Melingui, Bernard, additional, Nkembe Medounmga, Angeline, additional, Hougnang Tatmi, Luciole, additional, Etemgoua, Nathalie, additional, Kouesso, Vanessa, additional, Bugin, Jean, additional, Nzedjom, Celestine, additional, Ngoya, Roger, additional, Eyike, Jules, additional, Loudjom, Elyse, additional, Lonsti, Roger, additional, Dang, Ladi, additional, Bintar, Edward, additional, Njayong, Chantal, additional, Ngonsoa O, Cinthia, additional, Ndzeukap, Isabelle, additional, Dzoyem, Pascaline, additional, Dzokou, Clémentine, additional, Dindo, Berthe, additional, Komena, Eric Auguste, additional, Aka Bony, Roger, additional, Kouadio, Christian, additional, Danho, Serge, additional, Goli, Melissa, additional, Folquet, Madeleine, additional, Itchy, Max Valère, additional, Sidibé, Abdel, additional, Cissé, Lancina, additional, Ouattara, Joseph, additional, Konaté, Mamadou, additional, Amon-Tanoh Dick, Flore, additional, Cardena, Melissa, additional, Adonis-Koffi, Laurence, additional, Eugenie, Djabia, additional, Kouamé, Ferdinand, additional, Menan, Hervé, additional, Inwoley, André, additional, Ouassa, Timothée, additional, Nguessan, Marcelle Sandrine, additional, Manhiça, Emelva, additional, Zitha, Alcina, additional, Chiúle, Valter, additional, Muxanga, Eva, additional, Gune, Irene, additional, Lima, Yara, additional, Ribeiro, Jorge, additional, Maxanguana, Felismina, additional, Morais, Natália, additional, Manhiça, Julieta, additional, Give, Josefina, additional, Atumane, Jafito, additional, Lucas, Gelson, additional, Thai, Arsénio, additional, Chave, Adélio, additional, Guambe, Lúcia, additional, Issa, Faiaz, additional, Carneiro, Rosa, additional, Pene, Neusa, additional, Florindo, Natércia, additional, Machel, Dália, additional, Cumbane, Cecília, additional, Mendes, Helena, additional, Kitungwa, Mule, additional, Muianga, Valdo, additional, Tamele, Humberto, additional, Sulude, Adelino, additional, Mabota, Roda, additional, Comandante, Herquéria, additional, Massangaie, Abelardo, additional, Businge, Gerald Bright, additional, Namulinda, Faith, additional, Sserunjogi, Robert, additional, Nassozi, Rashidah, additional, Barungi, Charlotte, additional, Aanyu, Hellen, additional, Muwonge, Doreen, additional, Kagoya, Eva, additional, Aciparu, Serene, additional, Chemutai, Sophia, additional, Ntambi, Samuel, additional, Wasswa, Amir, additional, Nangozi, Juliet, additional, Tagoola, Abner, additional, Kenneth, Sajja, additional, Lubega, John Paul, additional, Nassali, Aidah, additional, Tagobera, Jessica, additional, Agwang, Christine, additional, Kalembe, Florence, additional, Ajambo, Annet, additional, Aguti, Elizabeth, additional, Kasibante, Samuel, additional, Matende, Henry, additional, Odongo, Israel Owen, additional, Mwanga Amumpaire, Juliet, additional, Ngabirano, Gertrude, additional, Kakwenza, Paul, additional, Nuwamanya, Simpson, additional, Nyangoma, Miria, additional, Nabbuto, Jane, additional, Abok, Florence, additional, Arinaitwe, Rinah, additional, Birungi, Diana, additional, Mwesigwa, Evans, additional, Atwine, Daniel, additional, Mbega, Hassan, additional, Orikiriza, Patrick, additional, Taremwa, Ivan, additional, Turyashemererwa, Esther, additional, Derrick, Hope, additional, Nyehangane, Dan, additional, Kaitano, Rodney, additional, Logoose, Susan, additional, Businge, Steven, additional, Ntambi, Charles, additional, Mugabi, Jerome, additional, Mzee, John, additional, Besigye, Julius, additional, Kanzira, Saul, additional, Turyatemba, Phionah, additional, Twebaze, Florence, additional, Hambulo, Chimuka, additional, Kapotwe, Vincent, additional, Ngambi, Marjory, additional, Kasakwa, Kunda, additional, Kapula, Chifunda, additional, Zulu, Susan, additional, Nawakwi, Grace, additional, Siasulingana, Teddy, additional, Chilonga, Jessy, additional, Chimbini, Maria, additional, Chilanga, Mutinta, additional, Inambao, Muleya, additional, Mwambazi, Mwate, additional, Halende, Barbra, additional, Mumba, Wyclef, additional, Mankunshe, Endreen, additional, Silavwe, Maureen, additional, Chakopo, Moses, additional, and Moono, Roy, additional

Published
2022
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10. Characterizing Undernourished Children Under-Five Years Old with Diarrhoea in Mozambique: A Hospital Based Cross-Sectional Study, 2015–2019

Author

Sambo, Júlia, primary, Cassocera, Marta, additional, Chissaque, Assucênio, additional, Bauhofer, Adilson Fernando Loforte, additional, Roucher, Clémentine, additional, Chilaúle, Jorfélia, additional, Cossa-Moiane, Idalécia, additional, Guimarães, Esperança L., additional, Manhique-Coutinho, Lena, additional, Anapakala, Elda, additional, Bero, Diocreciano M., additional, Langa, Jerónimo S., additional, Polman, Katja, additional, Gonçalves, Luzia, additional, and de Deus, Nilsa, additional

Published
2022
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11. Malaria morbidity and pyrethroid resistance after the introduction of insecticide-treated bednets and artemisinin-based combination therapies: a longitudinal study

Author

Trape, Jean-François, Tall, Adama, Diagne, Nafissatou, Ndiath, Ousmane, Ly, Alioune B, Faye, Joseph, Dieye-Ba, Fambaye, Roucher, Clémentine, Bouganali, Charles, Badiane, Abdoulaye, Sarr, Fatoumata Diene, Mazenot, Catherine, Touré-Baldé, Aïssatou, Raoult, Didier, Druilhe, Pierre, Mercereau-Puijalon, Odile, Rogier, Christophe, and Sokhna, Cheikh

Published
2011
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12. Evaluation of Artesunate-mefloquine as a Novel Alternative Treatment for Schistosomiasis in African Children (SchistoSAM): protocol of a proof-of-concept, open-label, two-arm, individually-randomised controlled trial

Author

Roucher, Clémentine, primary, Brosius, Isabel, additional, Mbow, Moustapha, additional, Faye, Babacar Thiendella, additional, De Hondt, Annelies, additional, Smekens, Bart, additional, Arango, Diana, additional, Burm, Christophe, additional, Tsoumanis, Achilleas, additional, Paredis, Linda, additional, van Herrewege, Yven, additional, Potters, Idzi, additional, Cisse, Badara, additional, Mboup, Souleymane, additional, Polman, Katja, additional, and Bottieau, Emmanuel, additional

Published
2021
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13. Non-typhoidal Salmonella intestinal carriage in a Schistosoma mansoni endemic community in a rural area of the Democratic Republic of Congo.

Author

UCL - SSS/IRSS - Institut de recherche santé et société, Mbuyi-Kalonji, Lisette, Barbé, Barbara, Nkoji, Gaëlle, Madinga, Joule, Roucher, Clémentine, Linsuke, Sylvie, Hermy, Marie, Heroes, Anne-Sophie, Mattheus, Wesley, Polman, Katja, Lutumba, Pascal, Phoba, Marie-France, Lunguya, Octavie, Jacobs, Jan, UCL - SSS/IRSS - Institut de recherche santé et société, Mbuyi-Kalonji, Lisette, Barbé, Barbara, Nkoji, Gaëlle, Madinga, Joule, Roucher, Clémentine, Linsuke, Sylvie, Hermy, Marie, Heroes, Anne-Sophie, Mattheus, Wesley, Polman, Katja, Lutumba, Pascal, Phoba, Marie-France, Lunguya, Octavie, and Jacobs, Jan

Abstract

BACKGROUND: Clinical observations and animal studies have suggested that Salmonella intestinal carriage is promoted by concurrent Schistosoma infection. The present study assessed association of Salmonella intestinal carriage and Schistosoma mansoni infection among individuals in a Schistosoma endemic area in sub-Saharan Africa. METHODS: From November 2015 to March 2016, a cross-sectional community-wide study was conducted in Kifua II, a rural village in Kongo Central Province, Democratic Republic of Congo. Stool samples were collected and analyzed for Salmonella intestinal carriage (culture) and Schistosoma mansoni infection (Kato Katz microscopy with determination of egg load). Salmonella Typhimurium and Enteritidis isolates were assessed for genetic similarity with blood culture isolates obtained during the same period in a neighboring hospital using multi-locus variable-numbers tandem repeat analysis (MLVA). RESULTS: A total of 1,108 participants were included (median age 15 years (IQR: 7-36), male-to-female ratio of 1:1.1). The overall prevalence of Schistosoma mansoni infection and non-typhoidal Salmonella carriage was 51.2% (95% CI: 48.2-54.1) and 3.4% (95% CI: 2.5-4.7) respectively, with 2.2% (95% CI: 1.5-3.2) of participants coinfected. The proportion of Salmonella carriage tended to be higher among Schistosoma mansoni infected participants compared to non-infected participants but this difference did not reach statistical significance (4.2% versus 2.6%, p = 0.132). However, the proportion of Salmonella carriage among participants with a heavy Schistosoma mansoni infection was significantly higher compared to those with a light and moderate infection (8.7% versus 3.2%, p = 0.012) and compared to Schistosoma mansoni negatives (8.7% versus 2.6%, p = 0.002). The 38 Salmonella isolates comprised five and four Enteritidis and Typhimurium serotypes respectively, the majority of them had MLVA types identical or similar to those observed among blood culture isolate

Published
2020

14. Community-based survey on helminth infections in Kwilu province, the Democratic Republic of the Congo, and implications for local control strategies

Author

Inocencio da Luz, Raquel, primary, Linsuke, Sylvie, additional, Roucher, Clémentine, additional, Mpanya, Alain, additional, Nyandele, Jane, additional, Mubwa Mungwele, Nono, additional, Mboma, Bienvenue Nsiembele, additional, Polman, Katja, additional, Hasker, Epco, additional, and Boelaert, Marleen, additional

Published
2020
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15. Non-typhoidal Salmonella intestinal carriage in a Schistosoma mansoni endemic community in a rural area of the Democratic Republic of Congo

Author

Mbuyi-Kalonji, Lisette, primary, Barbé, Barbara, additional, Nkoji, Gaëlle, additional, Madinga, Joule, additional, Roucher, Clémentine, additional, Linsuke, Sylvie, additional, Hermy, Marie, additional, Heroes, Anne-Sophie, additional, Mattheus, Wesley, additional, Polman, Katja, additional, Lutumba, Pascal, additional, Phoba, Marie-France, additional, Lunguya, Octavie, additional, and Jacobs, Jan, additional

Published
2020
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16. Maternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life: A mother-child cohort in Benin

Author

Agbota, Gino, Polman, Katja, Wieringa, Frank T, Campos-Ponce, Maiza, Accrombessi, Manfred, Yovo, Emmanuel, Roucher, Clémentine, Ezinmègnon, Sem, Marcos, Javier Yugueros, Vachot, Laurence, Tissières, Pierre, Massougbodji, Achille, Fievet, Nadine, Cot, Michel, Briand, Valérie, Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Endotoxines, Structures et Réponses de l'hôte (ESHR), Département Microbiologie (Dpt Microbio), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Infectious Diseases, and APH - Global Health

Subjects
Pulmonology, [SDV]Life Sciences [q-bio], Maternal Health, Pediatrics, Cohort Studies, Families, Labor and Delivery, Pregnancy, Risk Factors, Prevalence, Medicine and Health Sciences, Benin, Schistosomiasis, Children, Obstetrics and Gynecology, Breast Feeding, Infectious Diseases, Helminth Infections, Medicine, Female, Infants, Research Article, Neglected Tropical Diseases, Adult, Adolescent, Fever, Science, Mothers, Young Adult, SDG 3 - Good Health and Well-being, parasitic diseases, Parasitic Diseases, Humans, Infant, Newborn, Infant, Tropical Diseases, Malaria, Pregnancy Trimester, First, Logistic Models, Age Groups, Pregnancy Complications, Parasitic, Co-Infections, Multivariate Analysis, People and Places, Respiratory Infections, Birth, Women's Health, Population Groupings, Neonatology
Abstract

BackgroundMalaria and schistosomiasis represent two of the most prevalent and disabling parasitic infections in developing countries. Few studies have evaluated the effect of maternal schistosomiasis and malaria in the peri-conceptional period on infant's risk of infection.MethodsIn Benin, women were followed from the preconception period until delivery. Subsequently, their children were followed from birth to 3 months of age. Pre-pregnancy malaria, malaria in pregnancy (MiP)-determined monthly using a thick blood smear-and urinary schistosomiasis-determined once before pregnancy and once at delivery using urine filtration-were the main maternal exposures. Infant's febrile infection (fever with respiratory, gastrointestinal and/or cutaneous clinical signs anytime during follow-up) was the main outcome. In a secondary analysis, we checked the relation of malaria and schistosomiasis with infant's hemoglobin (Hb) concentration. Both effects were separately assessed using logistic/mixed linear regression models.ResultsThe prevalence of MiP was 35.7% with 10.8% occurring during the 1st trimester, and the prevalence of schistosomiasis was 21.8%. From birth to 3 months, 25.3% of infants had at least one episode of febrile infection. In multivariate analysis, MiP, particularly malaria in the 1st trimester, was significantly associated with a higher risk of infant's febrile infection (aOR = 4.99 [1.1; 22.6], p = 0.03). In secondary results, pre-pregnancy malaria and schistosomiasis were significantly associated with a lower infant's Hb concentration during the first 3 months.ConclusionWe evidenced the deleterious effect of maternal parasitic infections on infant's health. Our results argue in favor of the implementation of preventive strategies as early as in the peri-conception.

Published
2019

17. The rise and fall of malaria in a west African rural community, Dielmo, Senegal, from 1990 to 2012 : a 22 year longitudinal study

Author

Trape, Jean-François, Tall, A., Sokhna, Cheikh, Ly, A. B., Diagne, N., Ndiath, O., Mazenot, C., Richard, V., Badiane, A., Dieye-Ba, F., Faye, J., Ndiaye, G., Sarr, F. D., Roucher, Clémentine, Bouganali, C., Bassene, H., Toure-Balde, A., Roussilhon, C., Perraut, R., Spiegel, A., Sarthou, J. L., da Silva, L. P., Mercereau-Puijalon, O., Druilhe, P., and Rogier, C.

Subjects
parasitic diseases
Abstract

Background A better understanding of the effect of malaria control interventions on vector and parasite populations, acquired immunity, and burden of the disease is needed to guide strategies to eliminate malaria from highly endemic areas. We monitored and analysed the changes in malaria epidemiology in a village community in Senegal, west Africa, over 22 years. Methods Between 1990 and 2012, we did a prospective longitudinal study of the inhabitants of Dielmo, Senegal, to identify all episodes of fever and investigate the relation between malaria host, vector, and parasite. Our study induded daily medical surveillance with systematic parasite detection in individuals with fever. We measured parasite prevalence four times a year with cross-sectional surveys. We monitored malaria transmission monthly with night collection of mosquitoes. Malaria treatment changed over the years, from quinine (1990-94), to chloroquine (1995-2003), amodiaquine plus sulfadoxine-pyrimethamine (2003-06), and finally artesunate plus amodiaquine (2006-12). Insecticide-treated nets (ITNs) were introduced in 2008. Findings We monitored 776 villagers aged 0-101 years for 2 378 150 person-days of follow-up. Entomological inoculation rate ranged from 142.5 infected bites per person per year in 1990 to 482.6 in 2000, and 7.6 in 2012. Parasite prevalence in children declined from 87% in 1990 to 0.3 % in 2012. In adults, it declined from 58% to 0.3%. We recorded 23 546 fever episodes during the study, including 8243 clinical attacks caused by Plasmodium falciparum, 290 by Plasmodium malariae, and 219 by Plasmodium ovale. Three deaths were directly attributable to malaria, and two to severe adverse events of antimalarial drugs. The incidence of malaria attacks ranged from 1.50 attacks per person-year in 1990 to 2.63 in 2000, and to only 0.046 in 2012. The greatest changes were associated with the replacement of chloroquine and the introduction of ITNs. Interpretation Malaria control policies combining prompt treatment of clinical attacks and deployment of ITNs can nearly eliminate parasite carriage and greatly reduce the burden of malaria in populations exposed to intense perennial malaria transmission. The choice of drugs seems crucial. Rapid decline of clinical immunity allows rapid detection and treatment of novel infections and thus has a key role in sustaining effectiveness of combining artemisinin-based combination therapy and ITNs despite increasing pyrethroid resistance.

Published
2014

18. A new Rickettsia species found in fleas collected from human dwellings and from domestic cats and dogs in Senegal

Author

Roucher, Clémentine, Mediannikov, Oleg, Diatta, G., Trape, Jean-François, and Raoult, Didier

Subjects
Echidnophaga gallinacea, Spotted fever group, Rickettsia felis, Synosternus pallidus, flea, Rickettsia, Rickettsiosis, Syphonaptera, Ctenocephalides felis, Senegal
Abstract

The insects of the order Siphonaptera, commonly named fleas, are vectors of pathogens around the world. Our previous studies showed that 4.4% of acute febrile diseases in the Sine-Saloum region of Senegal were due to Rickettsia felis. The aim of this study was to explain the high prevalence of R. felis infections in two rural Senegalese populations by an entomological, systematic monitoring protocol. A total of 232 fleas from three species (Ctenocephalides felis, Echidnophaga gallinacea, and Synosternus pallidus) were collected by candle trapping and manually from pets in the villages of Dielmo and Ndiop during the year 2010. The fleas were then tested for the presence of Bartonella and Rickettsia species. No fleas were found to be positive for any Bartonella species or R. felis. Surprisingly, we found that 91.4% of S. pallidus were infected by a new Rickettsia species, which, based on sequence analysis of gltA, ompB, and two fragments of rpoB, was found to be closely related to R. felis. The results from this study did not explain the high incidence of R. felis infections in these Senegalese populations.

Published
2012

20. Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice

Author

Soulard, Valérie, primary, Bosson-Vanga, Henriette, additional, Lorthiois, Audrey, additional, Roucher, Clémentine, additional, Franetich, Jean- François, additional, Zanghi, Gigliola, additional, Bordessoulles, Mallaury, additional, Tefit, Maurel, additional, Thellier, Marc, additional, Morosan, Serban, additional, Le Naour, Gilles, additional, Capron, Frédérique, additional, Suemizu, Hiroshi, additional, Snounou, Georges, additional, Moreno-Sabater, Alicia, additional, and Mazier, Dominique, additional

Published
2015
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22. The rise and fall of malaria in a west African rural community, Dielmo, Senegal, from 1990 to 2012: a 22 year longitudinal study

Author

Trape, Jean-François, primary, Tall, Adama, additional, Sokhna, Cheikh, additional, Ly, Alioune Badara, additional, Diagne, Nafissatou, additional, Ndiath, Ousmane, additional, Mazenot, Catherine, additional, Richard, Vincent, additional, Badiane, Abdoulaye, additional, Dieye-Ba, Fambaye, additional, Faye, Joseph, additional, Ndiaye, Gora, additional, Diene Sarr, Fatoumata, additional, Roucher, Clémentine, additional, Bouganali, Charles, additional, Bassène, Hubert, additional, Touré-Baldé, Aissatou, additional, Roussilhon, Christian, additional, Perraut, Ronald, additional, Spiegel, André, additional, Sarthou, Jean-Louis, additional, da Silva, Luiz Pereira, additional, Mercereau-Puijalon, Odile, additional, Druilhe, Pierre, additional, and Rogier, Christophe, additional

Published
2014
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24. Looking for Tropheryma whipplei Source and Reservoir in Rural Senegal

Author

Keita, Alpha Kabinet, primary, Diatta, Georges, additional, Ratmanov, Pavel, additional, Bassene, Hubert, additional, Raoult, Didier, additional, Roucher, Clémentine, additional, Fenollar, Florence, additional, Sokhna, Cheikh, additional, Tall, Adama, additional, Trape, Jean-François, additional, and Mediannikov, Oleg, additional

Published
2013
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26. A 20-Year Longitudinal Study of Plasmodium ovale and Plasmodium malariae Prevalence and Morbidity in a West African Population.

Author

Roucher, Clémentine, Rogier, Christophe, Sokhna, Cheikh, Tall, Adama, and Trape, Jean-François

Subjects
*PLASMODIUM, *PROTOZOAN diseases, *DISEASE prevalence, *ETIOLOGY of diseases, *LONGITUDINAL method, *WEST Africans, *DISEASES
Abstract

Background: Plasmodium ovale and Plasmodium malariae have long been reported to be widely distributed in tropical Africa and in other major malaria-endemic areas of the world. However, little is known about the burden caused by these two malaria species. Methods and Findings: We did a longitudinal study of the inhabitants of Dielmo village, Senegal, between June, 1990, and December, 2010. We monitored the inhabitants for fever during this period and performed quarterly measurements of parasitemia. We analyzed parasitological and clinical data in a random-effect logistic regression model to investigate the relationship between the level of parasitemia and the risk of fever and to establish diagnostic criteria for P. ovale and P. malariae clinical attacks. The prevalence of P. ovale and P. malariae infections in asymptomatic individuals were high during the first years of the project but decreased after 2004 and almost disappeared in 2010 in relation to changes in malaria control policies. The average incidence densities of P. ovale and P. malariae clinical attacks were 0.053 and 0.093 attacks per person per year in children <15 years and 0.024 and 0.009 attacks per person per year in adults ≥15 years, respectively. These two malaria species represented together 5.9% of the malaria burden. Conclusions: P. ovale and P. malariae were a common cause of morbidity in Dielmo villagers until the recent dramatic decrease of malaria that followed the introduction of new malaria control policies. P. ovale and P. malariae may constitute an important cause of morbidity in many areas of tropical Africa. [ABSTRACT FROM AUTHOR]

Published
2014
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27. METABOLIC SYNDROME AND INTESTINAL PARASITES COEXIST IN A SEMI-URBAN CUBAN POPULATION.

Author

Hernández Hernández, Héctor, Manuel Rosado, Félix, Díaz, María Elena, Jerez, Luis Enrique, Roucher, Clémentine, and Polman, Katja

Abstract

Antecedents and objective. Metabolic Syndrome (MetS) results from overweight and other metabolic imbalances coexistence, and is increasing globally. Some intestinal parasites could be involved in MetS etiopathogenesis presumably through gut microbiome modifications. Therefore, potential relationships between MetS and intestinal parasitic infections should be studied. The objectives of our study were to evaluate the prevalences of MetS and intestinal parasitic infection and describe their relations in a semi-urban population of Havana. Methods. A descriptive cross-sectional study was conducted on 302 adults (mean age 52.2 ± 16.5 years). Several measurements were assessed including anthropometry (weight, height, body mass index, waist circumference), arterial blood pressure, biochemical variables (glucose, triglycerides, cholesterols. total, HDL, and LDL), and parasitic infection (by direct examination, Kato Katz, and Willis methods). MetS was diagnosed according to the International Diabetes Federation criteria. Results. MetS prevalence was 35.1% (95% CI. 28.8-41.2). Proportions of overweight, dyslipidemia and increased waist circumference were high. LDL-c was the metabolic marker with the highest frequency of vascular risk values (38.3%). The prevalence of intestinal parasitic infection was 31.5%. Protozoa infections (30.1%) were more frequent than helminth infections (1.7%). Parasitized individuals and those with mixed protozoa infection had higher frequencies of MetS than individuals non-parasitized or infected with a single protozoan, respectively. Conclusion. This study finds a high prevalence of MetS and a low prevalence of intestinal parasitic infection. Intestinal parasites and mixed protozoa infections are positively related to MetS. Other factors associated with an increase in MetS and related metabolic imbalances, along with the potential influence of some intestinal parasites, should be analyzed in-depth in this community and similar others. [ABSTRACT FROM AUTHOR]

Published
2021
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28. Development of tuberculosis treatment decision algorithms in children below 5 years hospitalised with severe acute malnutrition in Zambia and Uganda: a prospective diagnostic cohort study.

Author

Chabala C, Roucher C, Ton Nu Nguyet MH, Babirekere E, Inambao M, Businge G, Kapula C, Shankalala P, Nduna B, Mulenga V, Graham S, Wobudeya E, Bonnet M, and Marcy O

Abstract

Background: In children with severe acute malnutrition (SAM) tuberculosis is common, challenging to diagnose, and often fatal. We developed tuberculosis treatment decision algorithms (TDAs) for children under the age of 5 years with SAM., Methods: In this prospective diagnostic study, we enrolled and followed up children aged <60 months hospitalised with SAM at three tertiary hospitals in Zambia and Uganda from 4 November 2019 to 20 June 2022. We included children aged 2-59 months with SAM as defined by WHO and hospitalised following the WHO clinical criteria. We excluded children with current or history of antituberculosis treatment within the preceding 3 months. They underwent tuberculosis symptom screening, clinical assessment, chest X-ray, abdominal ultrasound, Xpert MTB/RIF Ultra (Ultra) and culture on respiratory and stool samples with 6 months follow-up. Tuberculosis was retrospectively defined using the 2015 standard case definition for childhood tuberculosis. We used logistic regression to develop diagnostic prediction models for a one-step diagnosis and a two-step screening and diagnostic approaches. We derived scores from models using WHO-recommended thresholds for sensitivity and proposed TDAs. This study is registered with ClinicalTrials.gov, NCT04240990., Findings: Of 1906 children hospitalised with SAM during the study period, 1230 were screened, 1152 were eligible and 603 were enrolled. Of the 603 children enrolled-median age 15 (inter-quartile range (IQR): 11-20) months and 65 (11.0%) living with HIV-114 (18.9%) were diagnosed with tuberculosis, including 51 (8.5%) with microbiological confirmation and 104 (17.2%) initiated treatment at a median of 6(IQR: 2-10) days after inclusion. 108 children were retrospectively classified as having tuberculosis resulting in a prevalence of 17.9% (95% confidence intervals (CI): 15.1; 21.2). 75 (69.4%) children with tuberculosis reported cough of any duration, 32 (29.6%) cough ≥2 weeks and 11 (10.2%) tuberculosis contact history. 535 children had complete data and were included in the diagnostic prediction model. The one-step diagnostic model had 15 predictors, including Ultra, clinical, radiographic, and abdominal features, an area under the receiving operating curve (AUROC) of 0.910, and derived TDA sensitivity of 86.14% (95% CI: 78.07-91.56) and specificity of 80.88% (95% CI: 76.91-84.30). The two-step model had AUROCs of 0.750 and 0.912 for screening and diagnosis, respectively, and derived combined TDA sensitivity of 79.21% (95% CI: 70.30-85.98) and a specificity of 83.64% (95% CI: 79.87-86.82)., Interpretation: Tuberculosis prevalence was high among hospitalised children with SAM, with atypical clinical features. TDAs achieved satisfactory diagnostic accuracy and could be used to improve diagnosis in this vulnerable group., Funding: Unitaid., Competing Interests: All authors declare no competing interests., (© 2024 The Author(s).)

Published
2024
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