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3. Safety and Efficacy of Renal Denervation in Patients Taking Antihypertensive Medications

Author

Wang, Yale, Jay, Desmond, McLaurin, Brent, Lomboy, Carl, Allaqaband, Suhail, Jan, Fuad, Gummadi, Bharat, Litt, Marc, Garcia, Fidel, Singh, Jasvindar, Brown, Angela, Choi, James, Paul, Ashley, Sharp, Andrew, Coulson, James, Nanjundappa, Aravinda, Thakker, Ganpat, Campbell, James, Honton, Benjamin, Farah, Bruno, Patel, Manesh, Gutierrez, Antonio, Tyson, Crystal, Svetkey, Laura, Fudim, Marat, Pagidipati, Neha, Jones, Schuyler, Vemulapalli, Sreekanth, Devireddy, Chandan, Kulshreshtha, Ambar, Wells, Bryan, Lea, Janice, Batson, Bryan, Wilkins, Robert, Sharif, Faisal, Khair, Abdullahi Mohamed, Pallippattu, Abhishek Wilson, Alhmoudi, Aishah Matar, Gaffney, Brian, Cawley, Christian, Gorry, Colin, Hamed, Hanan, Carron, Jennifer, Birrane, John, Rosseel, Liesbeth, Lunardi, Mattia, Cronin, Michael, McKittrick, Myles, Almagal, Naeif, Khalid, Noman, Shehahd, Qussai, Shahzad, Shirjeel, Fezzi, Simone, Tyulkin, Stanislav, Bel, Xavier Armario, Jolly, Sanjit, Yip, Gordon, Schwalm, Jon-David, Tsang, Michael, Mehta, Shamir, Lurz, Philipp C., Binner, Christian, Obradovic, Danilo, Fahr, Florian, Richter, Ines, Rotta detto Loria, Johannes, Fengler, Karl, Rommel, Karl-Philipp, Cuartas, Mateo Marin, Lerche, Matthias, Hartung, Philipp, Münch, Phillip, Höllriegel, Robert, John, Silke, Otsuji, Satoru, Kusumoto, Hirofumi, Tamaru, Hiroto, Ishibuchi, Kasumi, Hasegawa, Katsuyuki, Sugimoto, Ken, Kakishita, Mikio, Ishii, Rui, Takiuchi, Shin, Yasuda, Shingo, Nakabayashi, Sho, Yamamoto, Wataru, Higashino, Yorihiko, Shimatani, Yuji, Taniguchi, Yusuke, Tsioufis, Konstantinos, Kasiakogias, Alexandros, Konstantinidis, Dimitris, Andrikou, Eirini, Konstantinou, Konstantinos, Dimitriadis, Kyriakos, Kalos, Theodoros, Cohen, Debbie, Rene, Garvey, Cohen, Jordana, Bonanni, Maria, Denker, Matthew, Wickramisinghe, Rasi, Wilensky, Robert, Kobayashi, Tai, Anjan, Venkatesh, Huan, Yonghong, Haught, Walter Herbert, Krasnow, Joshua, Vasquez, Alejandro, Gessler, Carl, Roth, Christopher, Drenning, David, Velasquez, Enrique, Soliman, George, Murphy, James, Jain, Kaushik, Butler, Michael, Kanitkar, Mihir, Laney, Phillip, Hunter, Ross, Cheng, Shi-Chi, Wright, Thomas, Chapman, Neil, Arnold, Ahran, Nowbar, Alexandra, Janmohamed, Azara, Corden, Ben, Cook, Christopher, Rajkumar, Christopher, Keene, Daniel, Thompson, David, Seligman, Henry, Howard, James, Davies, Justin, Sweeney, Mark, Shun-Shin, Matthew, Foley, Michael, Quaife, Nicholas, Al-Lamee, Rasha, Hadjiphilippou, Savvas, Sen, Sayan, Ahmad, Yousif, Kario, Kazuomi, Shimizu, Hayato, Waki, Hirotaka, Narita, Keisuke, Shimpo, Masahisa, Hoshide, Satoshi, Komori, Takahiro, Ogoyama, Yukako, Ogata, Yukiyo, Oba, Yusuke, Bisharat, Mohanned, Lishmanov, Anton, Jeffords, Travis, Ghali, Magdi, Chia, Beth, Onsrud, Rachel, Rough, Randolph, Aoki, Jiro, Tomii, Daijiro, Mori, Fumiko, Kikushima, Hosei, Ninomiya, Kai, Yahagi, Kazuyuki, Tanabe, Kengo, Nakamura, Kosuke, Komiyama, Kota, Nakase, Masaaki, Asami, Masahiko, Setoguchi, Naoto, Tanaka, Tetsu, Horiuchi, Yu, Watanabe, Yusuke, Feldman, Dmitriy, Bergman, Geoffrey, Sherifi, Ines, Kim, Luke, Amin, Nivee, Minutello, Robert, Wong, S. Chiu, McCullough, Stephen, D'Souza, Richard, Kurdi, Hibba, Statton, Sarah, Watkinson, Tony, Bertolet, Barry, Gupta, Amit, Blossom, Benjamin, Bell, Chris, Hill, Douglas, Sierra, Francisco, Johnson, James, Estess, John, Adams, Joseph, McDuffie, Katie, Ferguson, Lee, Little, Nelson, Ballard, Richard Dane, Williams, Roger, Ikeda, Wanda, Calhoun, William, Carroll, William, Singh, Avneet, Hirsh, Benjamin, Meraj, Perwaiz, Jauhar, Rajiv, Golwala, Harsh, Rueda, Jose, Graham, Kellie, Al-Hakim, Ramsey, Rope, Robert, Kandzari, David, Bahrami, Dariush, Reedus, Denise, David, Shukri, Rehman, Iram, Zakaria, Khalid, Choksi, Nishit, Kazziha, Samer, Kumar, Sarwan, Saba, Souheil, Steigerwalt, Susan, Sirajeldin, Yassir, Hyder, Omar, Aronow, Herbert, Connors, Andrea, Shemin, Douglas, Bent, Clare, Levy, Terry, Kodoth, Vivek, Schlaich, Markus, Kiuchi, Marcio, Carnagarin, Revathy, Shetty, Sharad, Torre, Sabino, Levitt, Howard, Chen, Lin, Fan, Sarah, Waxman, Sergio, Porr, Wendy, Mangos, George, Smyth, Brendan, Lane, Cathie, Sader, Mark, Patel, Kirit Kumar, Rao, Anjani, Milford, Brett, Ahluwalia, Guneet, Sennott, Jaqueline, Field, Justin, Jena, Nihar, Loree, Stacy, Graham, John, Al-Hesayen, Abdul, Bagai, Akshay, Shite, Junya, Kozuki, Amane, Suzuki, Atsushi, Masuko, Eri, Soga, Fumitaka, Asada, Hiroyuki, Shibata, Hiroyuki, Nagoshi, Ryoji, Fujiwara, Ryudo, Kyo, Shokan, Miyata, Tomohiro, Kijima, Yoichi, Weil, Joachim, Griesinger, Lena, Hafer, Lukas, Starick, Rene-Alexander, Keil, Sebastian, Agdirlioglu, Tolga, Desch, Udo, Saito, Shigeru, Koyama, Eiji, Yamanaka, Futoshi, Yokoyama, Hiroaki, Tobita, Kazuki, Shishido, Koki, Yamaguchi, Masashi, Murakami, Masato, Moriyama, Noriaki, Takahashi, Saeko, Mizuno, Shingo, Yokota, Shohei, Hayashi, Takahiro, Yamada, Takashi, Yamagishi, Tamiharu, Sugiyama, Yoichi, Mashimo, Yuka, Tamaki, Yusuke, Tanaka, Yutaka, Lee, David, Ma, Adrian, Yeung, Alan, Noel, Thomas, Umana, Ernesto, Katopodis, John, Dixon, William, Walton, Tony, Rischin, Adam, Chee, Adrian, Leaney, Alexandra, Fernando, Himavan, Hopper, Ingrid, Bloom, Jason, Fairley, Jessica, Stehli, Julia, Segan, Julian, Sharma, Meenal, Fitzgerald, Melissa, Papandony, Michelle, Whyler, Naomi, Noaman, Samer, Ali, Shazeea, Jefferson, Brian, Reyes, David, Johnston, Thomas, Böhm, Michael, Höfling, Alexander, Berger, Ann-Kathrin, Cremers, Bodo, Millenaar, Dominic, Mahfoud, Felix, Zivanovic, Ina, Lucic, Jelena, Dederer, Juliane, Lauder, Lucas, Fischer, Patrick, Kulenthiran, Saarraangan, Ewen, Sebastian, Bewarder, Yvonne, Schmieder, Roland, Bosch, Agnes, Schmid, Axel, Ott, Christian, Kannenkeril, Dennis, Akarca, Ertan, Kistner, Iris, Kolwelter, Julie, Bihlmaier, Karl, Striepe, Kristina, Karg, Marina, Günes-Altan, Merve, Anna Friedrich, Stefanie Sofia, Jung, Susanne, Dienemann, Thomas, Ziakas, Antonios, Kouparanis, Antonios, Pagiantza, Areti, Peteinidou, Emmanouela, Didagelos, Matthaios, Psochias, Polykarpos Akis, Shishehbor, Mehdi, Meade, Ashley, Linetsky, Elena, Robinson, Monique, Kotter, John, Ziada, Khaled, Bachinsky, William, Garton, Alex, Stuck, Jason, Papademetriou, Vasilios, Chung, Annise, Li, Ping, Nagpal, Sameer, Remetz, Michael, Shah, Samit, Lynch, Shannon, Kandzari, David E., Townsend, Raymond R., Weber, Michael A., Schmieder, Roland E., Pocock, Stuart, Konstantinidis, Dimitrios, East, Cara, Cohen, Debbie L., Kobayashi, Taisei, Lee, David P., Schlaich, Markus P., Devireddy, Chandan M., Sharp, Andrew S.P., Anderson, Richard, Fahy, Martin, DeBruin, Vanessa, and Brar, Sandeep

Published
2023
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6. Safety and Efficacy of Renal Denervation in Patients Taking Antihypertensive Medications

Author

Kandzari, David E., primary, Townsend, Raymond R., additional, Kario, Kazuomi, additional, Mahfoud, Felix, additional, Weber, Michael A., additional, Schmieder, Roland E., additional, Pocock, Stuart, additional, Tsioufis, Konstantinos, additional, Konstantinidis, Dimitrios, additional, Choi, James, additional, East, Cara, additional, Lauder, Lucas, additional, Cohen, Debbie L., additional, Kobayashi, Taisei, additional, Schmid, Axel, additional, Lee, David P., additional, Ma, Adrian, additional, Weil, Joachim, additional, Agdirlioglu, Tolga, additional, Schlaich, Markus P., additional, Shetty, Sharad, additional, Devireddy, Chandan M., additional, Lea, Janice, additional, Aoki, Jiro, additional, Sharp, Andrew S.P., additional, Anderson, Richard, additional, Fahy, Martin, additional, DeBruin, Vanessa, additional, Brar, Sandeep, additional, Böhm, Michael, additional, Wang, Yale, additional, Jay, Desmond, additional, McLaurin, Brent, additional, Lomboy, Carl, additional, Allaqaband, Suhail, additional, Jan, Fuad, additional, Gummadi, Bharat, additional, Litt, Marc, additional, Garcia, Fidel, additional, Singh, Jasvindar, additional, Brown, Angela, additional, Paul, Ashley, additional, Sharp, Andrew, additional, Coulson, James, additional, Nanjundappa, Aravinda, additional, Thakker, Ganpat, additional, Campbell, James, additional, Honton, Benjamin, additional, Farah, Bruno, additional, Patel, Manesh, additional, Gutierrez, Antonio, additional, Tyson, Crystal, additional, Svetkey, Laura, additional, Fudim, Marat, additional, Pagidipati, Neha, additional, Jones, Schuyler, additional, Vemulapalli, Sreekanth, additional, Devireddy, Chandan, additional, Kulshreshtha, Ambar, additional, Wells, Bryan, additional, Batson, Bryan, additional, Wilkins, Robert, additional, Sharif, Faisal, additional, Khair, Abdullahi Mohamed, additional, Pallippattu, Abhishek Wilson, additional, Alhmoudi, Aishah Matar, additional, Gaffney, Brian, additional, Cawley, Christian, additional, Gorry, Colin, additional, Hamed, Hanan, additional, Carron, Jennifer, additional, Birrane, John, additional, Rosseel, Liesbeth, additional, Lunardi, Mattia, additional, Cronin, Michael, additional, McKittrick, Myles, additional, Almagal, Naeif, additional, Khalid, Noman, additional, Shehahd, Qussai, additional, Shahzad, Shirjeel, additional, Fezzi, Simone, additional, Tyulkin, Stanislav, additional, Bel, Xavier Armario, additional, Jolly, Sanjit, additional, Yip, Gordon, additional, Schwalm, Jon-David, additional, Tsang, Michael, additional, Mehta, Shamir, additional, Lurz, Philipp C., additional, Binner, Christian, additional, Obradovic, Danilo, additional, Fahr, Florian, additional, Richter, Ines, additional, Rotta detto Loria, Johannes, additional, Fengler, Karl, additional, Rommel, Karl-Philipp, additional, Cuartas, Mateo Marin, additional, Lerche, Matthias, additional, Hartung, Philipp, additional, Münch, Phillip, additional, Höllriegel, Robert, additional, John, Silke, additional, Otsuji, Satoru, additional, Kusumoto, Hirofumi, additional, Tamaru, Hiroto, additional, Ishibuchi, Kasumi, additional, Hasegawa, Katsuyuki, additional, Sugimoto, Ken, additional, Kakishita, Mikio, additional, Ishii, Rui, additional, Takiuchi, Shin, additional, Yasuda, Shingo, additional, Nakabayashi, Sho, additional, Yamamoto, Wataru, additional, Higashino, Yorihiko, additional, Shimatani, Yuji, additional, Taniguchi, Yusuke, additional, Kasiakogias, Alexandros, additional, Konstantinidis, Dimitris, additional, Andrikou, Eirini, additional, Konstantinou, Konstantinos, additional, Dimitriadis, Kyriakos, additional, Kalos, Theodoros, additional, Cohen, Debbie, additional, Rene, Garvey, additional, Cohen, Jordana, additional, Bonanni, Maria, additional, Denker, Matthew, additional, Wickramisinghe, Rasi, additional, Wilensky, Robert, additional, Kobayashi, Tai, additional, Anjan, Venkatesh, additional, Huan, Yonghong, additional, Haught, Walter Herbert, additional, Krasnow, Joshua, additional, Vasquez, Alejandro, additional, Gessler, Carl, additional, Roth, Christopher, additional, Drenning, David, additional, Velasquez, Enrique, additional, Soliman, George, additional, Murphy, James, additional, Jain, Kaushik, additional, Butler, Michael, additional, Kanitkar, Mihir, additional, Laney, Phillip, additional, Hunter, Ross, additional, Cheng, Shi-Chi, additional, Wright, Thomas, additional, Chapman, Neil, additional, Arnold, Ahran, additional, Nowbar, Alexandra, additional, Janmohamed, Azara, additional, Corden, Ben, additional, Cook, Christopher, additional, Rajkumar, Christopher, additional, Keene, Daniel, additional, Thompson, David, additional, Seligman, Henry, additional, Howard, James, additional, Davies, Justin, additional, Sweeney, Mark, additional, Shun-Shin, Matthew, additional, Foley, Michael, additional, Quaife, Nicholas, additional, Al-Lamee, Rasha, additional, Hadjiphilippou, Savvas, additional, Sen, Sayan, additional, Ahmad, Yousif, additional, Shimizu, Hayato, additional, Waki, Hirotaka, additional, Narita, Keisuke, additional, Shimpo, Masahisa, additional, Hoshide, Satoshi, additional, Komori, Takahiro, additional, Ogoyama, Yukako, additional, Ogata, Yukiyo, additional, Oba, Yusuke, additional, Bisharat, Mohanned, additional, Lishmanov, Anton, additional, Jeffords, Travis, additional, Ghali, Magdi, additional, Chia, Beth, additional, Onsrud, Rachel, additional, Rough, Randolph, additional, Tomii, Daijiro, additional, Mori, Fumiko, additional, Kikushima, Hosei, additional, Ninomiya, Kai, additional, Yahagi, Kazuyuki, additional, Tanabe, Kengo, additional, Nakamura, Kosuke, additional, Komiyama, Kota, additional, Nakase, Masaaki, additional, Asami, Masahiko, additional, Setoguchi, Naoto, additional, Tanaka, Tetsu, additional, Horiuchi, Yu, additional, Watanabe, Yusuke, additional, Feldman, Dmitriy, additional, Bergman, Geoffrey, additional, Sherifi, Ines, additional, Kim, Luke, additional, Amin, Nivee, additional, Minutello, Robert, additional, Wong, S. Chiu, additional, McCullough, Stephen, additional, D'Souza, Richard, additional, Kurdi, Hibba, additional, Statton, Sarah, additional, Watkinson, Tony, additional, Bertolet, Barry, additional, Gupta, Amit, additional, Blossom, Benjamin, additional, Bell, Chris, additional, Hill, Douglas, additional, Sierra, Francisco, additional, Johnson, James, additional, Estess, John, additional, Adams, Joseph, additional, McDuffie, Katie, additional, Ferguson, Lee, additional, Little, Nelson, additional, Ballard, Richard Dane, additional, Williams, Roger, additional, Ikeda, Wanda, additional, Calhoun, William, additional, Carroll, William, additional, Singh, Avneet, additional, Hirsh, Benjamin, additional, Meraj, Perwaiz, additional, Jauhar, Rajiv, additional, Golwala, Harsh, additional, Rueda, Jose, additional, Graham, Kellie, additional, Al-Hakim, Ramsey, additional, Rope, Robert, additional, Kandzari, David, additional, Bahrami, Dariush, additional, Reedus, Denise, additional, David, Shukri, additional, Rehman, Iram, additional, Zakaria, Khalid, additional, Choksi, Nishit, additional, Kazziha, Samer, additional, Kumar, Sarwan, additional, Saba, Souheil, additional, Steigerwalt, Susan, additional, Sirajeldin, Yassir, additional, Hyder, Omar, additional, Aronow, Herbert, additional, Connors, Andrea, additional, Shemin, Douglas, additional, Bent, Clare, additional, Levy, Terry, additional, Kodoth, Vivek, additional, Schlaich, Markus, additional, Kiuchi, Marcio, additional, Carnagarin, Revathy, additional, Torre, Sabino, additional, Levitt, Howard, additional, Chen, Lin, additional, Fan, Sarah, additional, Waxman, Sergio, additional, Porr, Wendy, additional, Mangos, George, additional, Smyth, Brendan, additional, Lane, Cathie, additional, Sader, Mark, additional, Patel, Kirit Kumar, additional, Rao, Anjani, additional, Milford, Brett, additional, Ahluwalia, Guneet, additional, Sennott, Jaqueline, additional, Field, Justin, additional, Jena, Nihar, additional, Loree, Stacy, additional, Graham, John, additional, Al-Hesayen, Abdul, additional, Bagai, Akshay, additional, Shite, Junya, additional, Kozuki, Amane, additional, Suzuki, Atsushi, additional, Masuko, Eri, additional, Soga, Fumitaka, additional, Asada, Hiroyuki, additional, Shibata, Hiroyuki, additional, Nagoshi, Ryoji, additional, Fujiwara, Ryudo, additional, Kyo, Shokan, additional, Miyata, Tomohiro, additional, Kijima, Yoichi, additional, Griesinger, Lena, additional, Hafer, Lukas, additional, Starick, Rene-Alexander, additional, Keil, Sebastian, additional, Desch, Udo, additional, Saito, Shigeru, additional, Koyama, Eiji, additional, Yamanaka, Futoshi, additional, Yokoyama, Hiroaki, additional, Tobita, Kazuki, additional, Shishido, Koki, additional, Yamaguchi, Masashi, additional, Murakami, Masato, additional, Moriyama, Noriaki, additional, Takahashi, Saeko, additional, Mizuno, Shingo, additional, Yokota, Shohei, additional, Hayashi, Takahiro, additional, Yamada, Takashi, additional, Yamagishi, Tamiharu, additional, Sugiyama, Yoichi, additional, Mashimo, Yuka, additional, Tamaki, Yusuke, additional, Tanaka, Yutaka, additional, Lee, David, additional, Yeung, Alan, additional, Noel, Thomas, additional, Umana, Ernesto, additional, Katopodis, John, additional, Dixon, William, additional, Walton, Tony, additional, Rischin, Adam, additional, Chee, Adrian, additional, Leaney, Alexandra, additional, Fernando, Himavan, additional, Hopper, Ingrid, additional, Bloom, Jason, additional, Fairley, Jessica, additional, Stehli, Julia, additional, Segan, Julian, additional, Sharma, Meenal, additional, Fitzgerald, Melissa, additional, Papandony, Michelle, additional, Whyler, Naomi, additional, Noaman, Samer, additional, Ali, Shazeea, additional, Jefferson, Brian, additional, Reyes, David, additional, Johnston, Thomas, additional, Höfling, Alexander, additional, Berger, Ann-Kathrin, additional, Cremers, Bodo, additional, Millenaar, Dominic, additional, Zivanovic, Ina, additional, Lucic, Jelena, additional, Dederer, Juliane, additional, Fischer, Patrick, additional, Kulenthiran, Saarraangan, additional, Ewen, Sebastian, additional, Bewarder, Yvonne, additional, Schmieder, Roland, additional, Bosch, Agnes, additional, Ott, Christian, additional, Kannenkeril, Dennis, additional, Akarca, Ertan, additional, Kistner, Iris, additional, Kolwelter, Julie, additional, Bihlmaier, Karl, additional, Striepe, Kristina, additional, Karg, Marina, additional, Günes-Altan, Merve, additional, Anna Friedrich, Stefanie Sofia, additional, Jung, Susanne, additional, Dienemann, Thomas, additional, Ziakas, Antonios, additional, Kouparanis, Antonios, additional, Pagiantza, Areti, additional, Peteinidou, Emmanouela, additional, Didagelos, Matthaios, additional, Psochias, Polykarpos Akis, additional, Shishehbor, Mehdi, additional, Meade, Ashley, additional, Linetsky, Elena, additional, Robinson, Monique, additional, Kotter, John, additional, Ziada, Khaled, additional, Bachinsky, William, additional, Garton, Alex, additional, Stuck, Jason, additional, Papademetriou, Vasilios, additional, Chung, Annise, additional, Li, Ping, additional, Nagpal, Sameer, additional, Remetz, Michael, additional, Shah, Samit, additional, and Lynch, Shannon, additional

Published
2023
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8. Comparison of a Pure Plug-Based Versus a Primary Suture-Based Vascular Closure Device Strategy for Transfemoral Transcatheter Aortic Valve Replacement: The CHOICE-CLOSURE Randomized Clinical Trial

Author

Abdel-Wahab, Mohamed, Hartung, Philipp, Dumpies, Oliver, Obradovic, Danilo, Wilde, Johannes, Majunke, Nicolas, Boekstegers, Peter, Müller, Ralf, Seyfarth, Melchior, Vorpahl, Marc, Kiefer, Philipp, Noack, Thilo, Leontyev, Sergey, Sandri, Marcus, Rotta detto Loria, Johannes, Kitamura, Mitsunobu, Borger, Michael Andrew, Funkat, Anne-Kathrin, Hohenstein, Sven, Desch, Steffen, Holzhey, David, and Thiele, Holger

Published
2022
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9. TCT-750 Outcomes Beyond 10 Years of Transcatheter Aortic Valve Replacement in High-Risk Patients With Severe Aortic Valve Stenosis

Author

Dietze, Ellen, primary, Richter, Ines, additional, Dumpies, Oliver, additional, Rotta detto Loria, Johannes, additional, Majunke, Nicolas, additional, Feistritzer, Hans-Josef, additional, Kiefer, Philipp, additional, Noack, Thilo, additional, Desch, Steffen, additional, Borger, Michael, additional, Thiele, Holger, additional, and Abdel-Wahab, Mohamed, additional

Published
2023
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10. TCT-745 Indications and 3-Year Outcomes of Redo-TAVR for Degenerated Transcatheter Aortic Valves: Experience From a Single High-Volume Center in Germany

Author

Richter, Ines, primary, Abdelhafez, Ahmed, additional, Dumpies, Oliver, additional, Rotta detto Loria, Johannes, additional, Majunke, Nicolas, additional, Feistritzer, Hans-Josef, additional, Kiefer, Philipp, additional, Noack, Thilo, additional, Desch, Steffen, additional, Thiele, Holger, additional, and Abdel-Wahab, Mohamed, additional

Published
2023
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11. Comparison of plug-based versus suture-based vascular closure for large-bore arterial access:a collaborative meta-analysis of observational and randomized studies

Author

Dumpies, Oliver, Jobs, Alexander, Obradovic, Danilo, van Wiechen, Maarten, Hartung, Philipp, Rotta detto Loria, Johannes, Wilde, Johannes, Majunke, Nicolas, Kiefer, Philipp, Noack, Thilo, Thiele, Holger, van Mieghem, Nicolas, Desch, Steffen, Abdel-Wahab, Mohamed, Dumpies, Oliver, Jobs, Alexander, Obradovic, Danilo, van Wiechen, Maarten, Hartung, Philipp, Rotta detto Loria, Johannes, Wilde, Johannes, Majunke, Nicolas, Kiefer, Philipp, Noack, Thilo, Thiele, Holger, van Mieghem, Nicolas, Desch, Steffen, and Abdel-Wahab, Mohamed

Abstract

Background: Large-bore arteriotomies can be percutaneously closed with suture-based or plug-based vascular closure device (VCD) strategies. The efficacy of both techniques remains controversial. Aims: We conducted a meta-analysis of comparative studies between both VCD strategies, focusing on the most commonly applied VCDs (MANTA and ProGlide). Methods: We searched MEDLINE, the Cochrane Central Register of Controlled Trials and Google scholar for observational studies (OS) and randomized controlled trials (RCT) comparing vascular closure with the MANTA-based and the ProGlide-based technique. The principal endpoint of this analysis was access-site related vascular complications. Both study types were analyzed separately. Results: Access-site related vascular complications were less frequent after vascular closure with the MANTA technique in the analysis of OS (RR 0.61 [95%CI 0.43–0.89], p = 0.01, I2 = 0%), but more frequent in the analysis of RCT data (RR 1.70 [95%CI 1.16–2.51], p = 0.01, I2 = 0%). Both data sets provided no significant difference between the VCD techniques in terms of overall bleeding events (OS: RR 0.57 [95%CI 0.32–1.02], p = 0.06, I2 = 70%; and RCT: RR 1.37 [95%CI 0.82–2.28], p = 0.23, I2 = 30%). RCT data showed that endovascular stenting or vascular surgery due to VCD failure occurred more often after MANTA application (RR 3.53 [95%CI 1.07–11.33], p = 0.04, I2 = 0%). Conclusions: While OS point to favorable outcomes for large-bore vascular closure with the MANTA-based technique, RCT data show that this strategy is associated with more access-site related vascular complications as well as endovascular stenting or vascular surgery due to device failure compared with the ProGlide-based technique. Graphical abstract: [Figure not available: see fulltext.].

Published
2023

18. Femoral arterial calcification and plug- vs. suture-based closure device strategies post transcatheter aortic valve implantation: Insights from CHOICE-CLOSURE

Author

Fitzgerald, Sean, Dumpies, Oliver, Shibata, Masafumi, Hartung, Philipp, Obradovic, Danilo, Boekstegers, Peter, Vorpahl, Marc, Rotta detto Loria, Johannes, Kiefer, Philipp, Desch, Steffen, Thiele, Holger, and Abdel-Wahab, Mohamed

Abstract

The location and severity of vascular calcification may influence closure device success in transfemoral transcatheter aortic valve implantation (TAVI).

Published
2023
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19. Nontypeable Haemophilus Influenzae Infection Upregulates the NLRP3 Inflammasome and Leads to Caspase-1-Dependent Secretion of Interleukin-1β — A Possible Pathway of Exacerbations in COPD.

Author

Rotta detto Loria, Johannes, Rohmann, Kristina, Droemann, Daniel, Kujath, Peter, Rupp, Jan, Goldmann, Torsten, and Dalhoff, Klaus

Subjects
*HAEMOPHILUS influenzae, *CASPASES, *INTERLEUKIN-1, *DISEASE exacerbation, *ETIOLOGY of diseases, *GENETIC regulation, *OBSTRUCTIVE lung diseases, *CYTOKINES, *IMMUNE system, *BACTERIA
Abstract

Rationale: Nontypeable Haemophilus influenzae (NTHi) is the most common cause for bacterial exacerbations in chronic obstructive pulmonary disease (COPD). Recent investigations suggest the participation of the inflammasome in the pathomechanism of airway inflammation. The inflammasome is a cytosolic protein complex important for early inflammatory responses, by processing Interleukin-1β (IL-1β) to its active form. Objectives: Since inflammasome activation has been described for a variety of inflammatory diseases, we investigated whether this pathway plays a role in NTHi infection of the airways. Methods: A murine macrophage cell line (RAW 264.7), human alveolar macrophages and human lung tissue (HLT) were stimulated with viable or non-viable NTHi and/or nigericin, a potassium ionophore. Secreted cytokines were measured with ELISA and participating proteins detected via Western Blot or immunohistochemistry. Measurements and Main Results: Western Blot analysis of cells and immunohistochemistry of lung tissue detected the inflammasome key components NLRP3 and caspase-1 after stimulation, leading to a significant induction of IL-1β expression (RAW: control at the lower detection limit vs. NTHi 505±111pg/ml, p<0.01). Inhibition of caspase-1 in human lung tissue led to a significant reduction of IL-1β and IL-18 levels (IL-1β: NTHi 24 h 17423±3198pg/ml vs. NTHi+Z-YVAD-FMK 6961±1751pg/ml, p<0.01). Conclusion: Our data demonstrate the upregulation of the NRLP3-inflammasome during NTHi-induced inflammation in respiratory cells and tissues. Our findings concerning caspase-1 dependent IL-1β release suggest a role for the inflammasome in respiratory tract infections with NTHi which may be relevant for the pathogenesis of bacterial exacerbations in COPD. [ABSTRACT FROM AUTHOR]

Published
2013
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20. Prognostic significance and clinical utility of left atrial reservoir strain in transcatheter aortic valve replacement.

Author

von Roeder M, Maeder M, Wahl V, Kitamura M, Rotta Detto Loria J, Dumpies O, Rommel KP, Kresoja KP, Blazek S, Richter I, Majunke N, Desch S, Thiele H, Lurz P, and Abdel-Wahab M

Subjects
Humans, Female, Aged, 80 and over, Male, Prognosis, Aortic Valve surgery, Treatment Outcome, Risk Factors, Time Factors, Severity of Illness Index, Transcatheter Aortic Valve Replacement methods, Aortic Valve Stenosis diagnostic imaging, Aortic Valve Stenosis surgery, Aortic Valve Stenosis etiology
Abstract

Aims: Patients with diastolic dysfunction (DD) experience worse outcomes after transcatheter aortic valve replacement (TAVR). We investigated the prognostic value and clinical utility of left atrial reservoir strain (LARS) in patients undergoing TAVR for aortic stenosis (AS)., Methods and Results: All consecutive patients undergoing TAVR between January 2018 and December 2018 were included if discharge echocardiography and follow-up were available. LARS was derived from 2D-speckle-tracking. Patients were grouped into three tertiles according to LARS. DD was analysed using the ASE/EACVI-algorithm. The primary outcome was a composite of all-cause death and readmission for worsening heart failure 12 months after TAVR. Overall, 606 patients were available [age 80 years, interquartile range (IQR) 77-84], including 53% women. Median LARS was 13.0% (IQR 8.4-18.3). Patients were classified by LARS tertiles [mildly impaired 21.4% (IQR 18.3-24.5), moderately impaired 13.0% (IQR 11.3-14.6), severely impaired 7.1% (IQR 5.4-8.4), P < 0.0001]. The primary outcome occurred more often in patients with impaired LARS (mildly impaired 7.4%, moderately impaired 13.4%, and severely impaired 25.7%, P < 0.0001). On adjusted multivariable Cox regression analysis, LARS tertiles [hazard ratio (HR) 0.62, 95% confidence interval (CI) 0.44-0.86, P = 0.005] and higher degree of tricuspid regurgitation (HR 1.82, 95% CI 1.23-2.98, P = 0.003) were the only significant predictors of the primary endpoint. Importantly, DD was unavailable in 56% of patients, but LARS assessment allowed for reliable prognostication regarding the primary endpoint in subgroups without DD assessment (HR 0.64, 95% CI 0.47-0.87, P = 0.003)., Conclusion: Impaired LARS is independently associated with worse outcomes in patients undergoing TAVR. LARS allows for risk stratification at discharge even in patients where DD cannot be assessed by conventional echocardiographic means., Competing Interests: Conflict of interest: M.A.-W. reports that his hospital receives speaker’s honoraria and/or consultancy fees on his behalf from Boston Scientific and Medtronic., (© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Published
2024
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21. Acute myocardial infarction associated with prosthetic valve leaflet thrombosis after transcatheter aortic valve implantation: a case report.

Author

Rotta Detto Loria J, Thiele H, and Abdel-Wahab M

Abstract

Background: Fatal thrombo-embolic events like cerebral stroke or myocardial infarction are rare complications of prosthetic heart valve leaflet thrombosis. Nevertheless, prevention and management of leaflet thrombosis is gaining increased attention, particularly with the widespread adoption of transcatheter heart valves., Case Summary: We herein present the case of a 79-year-old man who had undergone a transcatheter aortic valve implantation procedure. Seven months later, he presented with a non-ST-segment elevation myocardial infarction. Coronary angiography did not reveal obstructive lesions. A dedicated cardiac computed tomography scan showed thrombosis of both right- and non-coronary leaflets of the prosthetic aortic valve, while prosthetic valve function was normal on echocardiography. Transmural myocardial infarction lesions in the midventricular and apical inferior wall were detected by cardiac magnetic resonance imaging., Discussion: Subclinical leaflet thrombosis of prosthetic aortic valves is a common finding. In this case report, we show that myocardial infarction presumably due to leaflet thrombosis was the first symptom in an otherwise asymptomatic patient. This finding raises the question of the validity in distinguishing between subclinical and clinical leaflet thrombosis based on prosthetic valve function., (© The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Cardiology.)

Published
2020
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