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5 results on '"Rothwell, Alice R."'

1. Microbial-Host Co-metabolites Are Prodromal Markers Predicting Phenotypic Heterogeneity in Behavior, Obesity, and Impaired Glucose Tolerance

Author

Dumas, Marc-Emmanuel, Rothwell, Alice R., Hoyles, Lesley, Aranias, Thomas, Chilloux, Julien, Calderari, Sophie, Noll, Elisa M., Péan, Noémie, Boulangé, Claire L., Blancher, Christine, Barton, Richard H., Gu, Quan, Fearnside, Jane F., Deshayes, Chloé, Hue, Christophe, Scott, James, Nicholson, Jeremy K., and Gauguier, Dominique

Published
2017
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2. Microbiome Inhibition of IRAK-4 by Trimethylamine Mediates Metabolic and Immune Benefits in High-Fat-Diet-induced Insulin Resistance

Author

Chilloux, Julien, primary, Brial, Francois, additional, Everard, Amandine, additional, Smyth, David, additional, Zhang, Liyong, additional, Plovier, Hubert, additional, Myridakis, Antonis, additional, Hoyles, Lesley, additional, Fuchs, Julian E., additional, Blancher, Christine, additional, Gencer, Selin, additional, Martinez-Gili, Laura, additional, Fearnside, Jane F., additional, Barton, Richard H., additional, Neves, Ana Luisa, additional, Rothwell, Alice R., additional, Gérard, Christelle, additional, Calderari, Sophie, additional, Boulangé, Claire L., additional, Patel, Saroor, additional, Scott, James, additional, Glen, Robert C., additional, Gooderham, Nigel J., additional, Nicholson, Jeremy K., additional, Gauguier, Dominique, additional, Liu, Peter P., additional, Cani, Patrice D., additional, and Dumas, Marc-Emmanuel, additional

Published
2018
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3. Nutrigenomics of High Fat Diet Induced Obesity in Mice Suggests Relationships between Susceptibility to Fatty Liver Disease and the Proteasome

Author

Waller-Evans, Helen, primary, Hue, Christophe, additional, Fearnside, Jane, additional, Rothwell, Alice R., additional, Lockstone, Helen E., additional, Caldérari, Sophie, additional, Wilder, Steven P., additional, Cazier, Jean-Baptiste, additional, Scott, James, additional, and Gauguier, Dominique, additional

Published
2013
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4. Phylometabonomic Patterns of Adaptation to High Fat Diet Feeding in Inbred Mice

Author

Fearnside, Jane F., primary, Dumas, Marc-Emmanuel, additional, Rothwell, Alice R., additional, Wilder, Steven P., additional, Cloarec, Olivier, additional, Toye, Ayo, additional, Blancher, Christine, additional, Holmes, Elaine, additional, Tatoud, Roger, additional, Barton, Richard H., additional, Scott, James, additional, Nicholson, Jeremy K., additional, and Gauguier, Dominique, additional

Published
2008
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5. Microbial-host co-metabolites are prodromal markers predicting phenotypic heterogeneity in behavior, obesity, and impaired glucose tolerance

Author

Hoyles, Lesley, Aranias, Thomas, Chilloux, Julien, Calderari, Sophie, Noll, Elisa M., Péan, Noémie, Boulangé, Claire L., Blancher, Christine, Barton, Richard H., Gu, Quan, Fearnside, Jane F., Deshayes, Chloé, Hue, Christophe, Scott, James, Nicholson, Jeremy K, Gauguier, Dominique, Dumas, Marc-Emmanuel, and Rothwell, Alice R.

Subjects
anxiete, obésité, sécrétion d'insuline, TMAO, anxiety, endoplasmic reticulum stress, impaired glucose tolerance, insulin secretion, metabolome, microbiome, natural phenotypic variation, obesity, transcriptome, trimethylamine-N-oxide, Biologie du développement, Development Biology
Abstract

The influence of the gut microbiome on metabolic and behavioral traits is widely accepted, though the microbiome-derived metabolites involved remain unclear. We carried out untargeted urine (1)H-NMR spectroscopy-based metabolic phenotyping in an isogenic C57BL/6J mouse population (n = 50) and show that microbial-host co-metabolites are prodromal (i.e., early) markers predicting future divergence in metabolic (obesity and glucose homeostasis) and behavioral (anxiety and activity) outcomes with 94%-100% accuracy. Some of these metabolites also modulate disease phenotypes, best illustrated by trimethylamine-N-oxide (TMAO), a product of microbial-host co-metabolism predicting future obesity, impaired glucose tolerance (IGT), and behavior while reducing endoplasmic reticulum stress and lipogenesis in 3T3-L1 adipocytes. Chronic in vivo TMAO treatment limits IGT in HFD-fed mice and isolated pancreatic islets by increasing insulin secretion. We highlight the prodromal potential of microbial metabolites to predict disease outcomes and their potential in shaping mammalian phenotypic heterogeneity.

Published
2017

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