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8 results on '"Rothe, Maurine"'

1. Targeting intracellular WT1 in AML with a novel RMF-peptide-MHC-specific T-cell bispecific antibody

Author

Augsberger, Christian, Hänel, Gerulf, Xu, Wei, Pulko, Vesna, Hanisch, Lydia Jasmin, Augustin, Angelique, Challier, John, Hunt, Katharina, Vick, Binje, Rovatti, Pier Eduardo, Krupka, Christina, Rothe, Maurine, Schönle, Anne, Sam, Johannes, Lezan, Emmanuelle, Ducret, Axel, Ortiz-Franyuti, Daniela, Walz, Antje-Christine, Benz, Jörg, Bujotzek, Alexander, Lichtenegger, Felix S., Gassner, Christian, Carpy, Alejandro, Lyamichev, Victor, Patel, Jigar, Konstandin, Nikola, Tunger, Antje, Schmitz, Marc, von Bergwelt-Baildon, Michael, Spiekermann, Karsten, Vago, Luca, Jeremias, Irmela, Marrer-Berger, Estelle, Umaña, Pablo, Klein, Christian, and Subklewe, Marion

Published
2021
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3. Fusion of Bacterial Flagellin to a Dendritic Cell-Targeting αCD40 Antibody Construct Coupled With Viral or Leukemia-Specific Antigens Enhances Dendritic Cell Maturation and Activates Peptide-Responsive T Cells

Author

Schmitt, Saskia, primary, Tahk, Siret, additional, Lohner, Alina, additional, Hänel, Gerulf, additional, Maiser, Andreas, additional, Hauke, Martina, additional, Patel, Lubna, additional, Rothe, Maurine, additional, Josenhans, Christine, additional, Leonhardt, Heinrich, additional, Griffioen, Marieke, additional, Deiser, Katrin, additional, Fenn, Nadja C., additional, Hopfner, Karl-Peter, additional, and Subklewe, Marion, additional

Published
2020
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4. Toll‐like receptor 7/8‐matured RNA‐transduced dendritic cells as post‐remission therapy in acute myeloid leukaemia: results of a phase I trial

Author

Lichtenegger, Felix S, primary, Schnorfeil, Frauke M, additional, Rothe, Maurine, additional, Deiser, Katrin, additional, Altmann, Torben, additional, Bücklein, Veit L, additional, Köhnke, Thomas, additional, Augsberger, Christian, additional, Konstandin, Nikola P, additional, Spiekermann, Karsten, additional, Moosmann, Andreas, additional, Boehm, Stephan, additional, Boxberg, Melanie, additional, Heemskerk, Mirjam HM, additional, Goerlich, Dennis, additional, Wittmann, Georg, additional, Wagner, Beate, additional, Hiddemann, Wolfgang, additional, Schendel, Dolores J, additional, Kvalheim, Gunnar, additional, Bigalke, Iris, additional, and Subklewe, Marion, additional

Published
2020
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5. Targeting Intracellular WT1 in AML Utilizing a T Cell Bispecific Antibody Construct: Augmenting Efficacy through Combination with Lenalidomide

Author

Klein, Christian, primary, Augsberger, Christian, additional, Xu, Wei, additional, Heitmüller, Christina, additional, Hanisch, Lydia, additional, Sam, Johannes, additional, Pulko, Vesna, additional, Schönle, Anne, additional, Challier, John, additional, Carpy, Alejandro, additional, Konstandin, Nikola, additional, Rothe, Maurine, additional, Hänel, Gerulf, additional, Bücklein, Veit, additional, Lichtenegger, Felix S., additional, Tunger, Antje, additional, Schmitz, Marc, additional, von Bergwelt, Michael, additional, Spiekermann, Karsten, additional, Umana, Pablo, additional, and Subklewe, Marion, additional

Published
2019
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7. Induction of Antigen-Specific T-Cell Responses through Dendritic Cell Vaccination in AML: Results of a Phase I/II Trial and Ex Vivo Enhancement By Checkpoint Blockade

Author

Lichtenegger, Felix S., primary, Deiser, Katrin, additional, Rothe, Maurine, additional, Schnorfeil, Frauke M., additional, Krupka, Christina, additional, Augsberger, Christian, additional, Köhnke, Thomas, additional, Bücklein, Veit L., additional, Altmann, Torben, additional, Moosmann, Andreas, additional, Brüggemann, Monika, additional, Heemskerk, Mirjam H.M., additional, Wittmann, Georg, additional, Wagner, Beate, additional, Hiddemann, Wolfgang, additional, Bigalke, Iris, additional, Kvalheim, Gunnar, additional, and Subklewe, Marion, additional

Published
2016
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8. Induction of Antigen-Specific T-Cell Responses through Dendritic Cell Vaccination in AML: Results of a Phase I/II Trial and Ex VivoEnhancement By Checkpoint Blockade

Author

Lichtenegger, Felix S., Deiser, Katrin, Rothe, Maurine, Schnorfeil, Frauke M., Krupka, Christina, Augsberger, Christian, Köhnke, Thomas, Bücklein, Veit L., Altmann, Torben, Moosmann, Andreas, Brüggemann, Monika, Heemskerk, Mirjam H.M., Wittmann, Georg, Wagner, Beate, Hiddemann, Wolfgang, Bigalke, Iris, Kvalheim, Gunnar, and Subklewe, Marion

Abstract

Postremission therapy is critical for successful elimination of minimal residual disease (MRD) in acute myeloid leukemia (AML). Innovative treatment options are needed for patients that are not eligible for allogeneic stem cell transplantation. As the intrinsic immune response against leukemia-associated antigens (LAAs) is generally low, the clinical application of checkpoint inhibitors as monotherapy is less promising in AML compared to other hemato-oncological diseases. Therapeutic vaccination with autologous dendritic cells (DCs) loaded with LAAs is a promising treatment strategy to induce anti-leukemic immune responses.

Published
2016
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