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6 results on '"Rostock, Lida"'

1. Transcription activation by the resistance protein AlbA as a tool to evaluate derivatives of the antibiotic albicidin

Author

Kosol, Simone, primary, Rostock, Lida, additional, Barsig, Jonas, additional, Tabarelli, Theresa, additional, Hommernick, Kay, additional, Kulike, Marcel, additional, Eulberg, Tobias, additional, Seidel, Maria, additional, Behroz, Iraj, additional, Kleebauer, Leonardo, additional, Grätz, Stefan, additional, Mainz, Andi, additional, and Süssmuth, Roderich D., additional

Published
2023
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2. 713 The PRAME opportunity – high peptide copy numbers, homogenous expression and high prevalence to address a broad patient population across different solid cancers with TCR-based therapeutics

Author

Britten, Cedrik, primary, Araujo, Dejka, additional, Backert, Linus, additional, Bokemeyer, Carsten, additional, Carvajal, Richard, additional, Chatterjee, Manik, additional, Dash, Asim, additional, Freudenmann, Lena, additional, Fritsche, Jens, additional, Fuhrmann, David, additional, Goldfinger, Valentina, additional, Holderried, Tobias, additional, Hoffgaard, Franziska, additional, Hukelmann, Jens, additional, Jazaeri, Amir, additional, Kaseb, Ahmed, additional, Köhler, Florian, additional, Kowalewski, Daniel, additional, Luke, Jason, additional, Morris, Van, additional, Mukhi, Shivani, additional, Ott, Martina, additional, Reshef, Ran, additional, Römer, Michael, additional, Rostock, Lida, additional, Satam, Swapna, additional, Satelli, Arun, additional, Schräder, Christoph, additional, Thambi, Merline, additional, Tsimberidou, Apostolia, additional, Wagner, Maike, additional, Wermke, Martin, additional, Schuster, Heiko, additional, Schoor, Oliver, additional, and Weinschenk, Toni, additional

Published
2022
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3. Extensive structure‐activity relationship study of albicidin’s C‐terminal dipeptidic p‐aminobenzoic acid moiety

Author

Behroz, Iraj, Durkin, Patrick, Grätz, Stefan, Seidel, Maria, Rostock, Lida, Spinczyk, Marcello, Weston, John B., and Süßmuth, Roderich D.

Subjects
ddc:540, ddc:660
Abstract

Albicidin is a recently described natural product that strongly inhibits bacterial DNA gyrase. The pronounced activity, particularly against Gram‐negative bacteria, turns it into a promising lead structure for an antibacterial drug. Hence, structure–activity relationship studies are key for the in‐depth understanding of structural features/moieties affecting gyrase inhibition, antibacterial activity and overcoming resistance. The 27 newly synthesized albicidins give profound insights into possibilities for variations of the C‐terminus. Furthermore, in the present study, a novel derivative has been identified as overcoming resistance posed by the Klebsiella‐protease AlbD. Structural modifications include, for example, azahistidine replacing the previous instable cyanoalanine as the central amino acid, as well as a triazole amide bond isostere between building blocks D and E.

Published
2019

5. Molecular insights into antibiotic resistance - how a binding protein traps albicidin

Author

Rostock, Lida, primary, Driller, Ronja, additional, Grätz, Stefan, additional, Kerwat, Dennis, additional, von Eckardstein, Leonard, additional, Petras, Daniel, additional, Kunert, Maria, additional, Alings, Claudia, additional, Schmitt, Franz-Josef, additional, Friedrich, Thomas, additional, Wahl, Markus C., additional, Loll, Bernhard, additional, Mainz, Andi, additional, and Süssmuth, Roderich D., additional

Published
2018
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6. Extensive Structure-Activity Relationship Study of Albicidin's C-Terminal Dipeptidic p-Aminobenzoic Acid Moiety.

Author

Behroz I, Durkin P, Grätz S, Seidel M, Rostock L, Spinczyk M, Weston JB, and Süssmuth RD

Abstract

Albicidin is a recently described natural product that strongly inhibits bacterial DNA gyrase. The pronounced activity, particularly against Gram-negative bacteria, turns it into a promising lead structure for an antibacterial drug. Hence, structure-activity relationship studies are key for the in-depth understanding of structural features/moieties affecting gyrase inhibition, antibacterial activity and overcoming resistance. The 27 newly synthesized albicidins give profound insights into possibilities for variations of the C-terminus. Furthermore, in the present study, a novel derivative has been identified as overcoming resistance posed by the Klebsiella-protease AlbD. Structural modifications include, for example, azahistidine replacing the previous instable cyanoalanine as the central amino acid, as well as a triazole amide bond isostere between building blocks D and E., (© 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.)

Published
2019
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