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3. Understanding bovine embryo elongation: a transcriptomic study of trophoblastic vesicles.

Author

Degrelle, Séverine A., Fulin Liu, Laloe, Denis, Richard, Christophe, Bourhis, Daniel Le, Rossignol, Marie-Noëlle, and Hue, Isabelle

Abstract

Background: During the process of elongation, the embryo increases in size within the uterus, while the extra-embryonic tissues (EETs) develop and differentiate in preparation for implantation. As it grows, the ovoid embryo transforms into a tubular form first and then a filamentous form. This process is directed by numerous genes and pathways, the expression of which may be altered in the case of developmental irregularities such as when the conceptus is shorter than expected or when the embryo develops after splitting. In bovines, efforts to understand the molecular basis of elongation have employed trophoblastic vesicles (TVs)—short tubular EET pieces that lack an embryo—which also elongate in vivo. To date, however, we lack molecular analyses of TVs at the ovoid or filamentous stages that might shed light on the expression changes involved. Methods: Following in vivo development, we collected bovine conceptuses from the ovoid (D12) to filamentous stages (D18), sectioned them into small pieces with or without their embryonic disc (ED), and then, transferred them to a receptive bovine uterus to assess their elongation abilities. We also grew spherical blastocysts in vitro up to D8 and subjected them to the same treatment. Then, we assessed the differences in gene expression between different samples and fully elongating controls at different stages of elongation using a bovine array (10 K) and an extended qPCR array comprising 224 genes across 24 pathways. Results: In vivo, TVs elongated more or less depending on the stage at which they had been created and the time spent in utero. Their daily elongation rates differed from control EET, with the rates of TVs sometimes resembling those of earlier-stage EET. Overall, the molecular signatures of TVs followed a similar developmental trajectory as intact EET from D12–D18. However, within each stage, TVs and intact EET displayed distinct expression dynamics, some of which were shared with other short epithelial models. Conclusion: Differences between TVs and EET likely result from multiple factors, including a reduction in the length and signaling capabilities of TVs, delayed elongation from inadequate uterine signals, and modified crosstalk between the conceptus and the uterus. These findings confirm that close coordination between uterine, embryonic, and extra-embryonic tissues is required to orchestrate proper elongation and, based on the partial differentiation observed, raise questions about the presence/absence of certain developmental cues or even their asynchronies. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Genetic Features of Mycobacterium avium subsp. paratuberculosis Strains Circulating in the West of France Deciphered by Whole-Genome Sequencing

Author

Conde, Cyril, primary, Thézé, Julien, additional, Cochard, Thierry, additional, Rossignol, Marie-Noëlle, additional, Fourichon, Christine, additional, Delafosse, Arnaud, additional, Joly, Alain, additional, Guatteo, Raphael, additional, Schibler, Laurent, additional, Bannantine, John P., additional, and Biet, Franck, additional

Published
2022
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5. Comparative analysis of the caecal tonsil transcriptome in two chicken lines experimentally infected with Salmonella Enteritidis

Author

Cazals, Anaïs, primary, Rau, Andrea, additional, Estellé, Jordi, additional, Bruneau, Nicolas, additional, Coville, Jean-Luc, additional, Menanteau, Pierrette, additional, Rossignol, Marie-Noëlle, additional, Jardet, Deborah, additional, Bevilacqua, Claudia, additional, Bed’Hom, Bertrand, additional, Velge, Philippe, additional, and Calenge, Fanny, additional

Published
2022
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7. Comparative analysis of the caecal tonsil transcriptome in two hen lines experimentally infected withSalmonellaEnteritidis

Author

Cazals, Anaïs, primary, Rau, Andrea, additional, Estellé, Jordi, additional, Bruneau, Nicolas, additional, Coville, Jean-Luc, additional, Menanteau, Pierrette, additional, Rossignol, Marie-Noëlle, additional, Jardet, Deborah, additional, Bevilacqua, Claudia, additional, Bed’hom, Bertrand, additional, Velge, Philippe, additional, and Calenge, Fanny, additional

Published
2022
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9. Draft genome sequences of 142 Mycobacterium avium subsp. paratuberculosis strains isolated from naturally infected dairy cattle

Author

Conde, Cyril, Branger, Maxime, Cochard, Thierry, Rossignol, Marie-Noëlle, Fourichon, Christine, Delafosse, Arnaud, Davergne, Aurore, Joly, Alain, Ngwa-Mbot, David, Journaux, Laurent, GUATTEO, Raphael, Schibler, Laurent, Biet, Franck, Infectiologie et Santé Publique (UMR ISP), Université de Tours-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Génétique Animale et Biologie Intégrative (GABI), Université Paris-Saclay-AgroParisTech-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Biologie, Epidémiologie et analyse de risque en Santé Animale (BIOEPAR), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Groupement de Défense Sanitaire Orne (GDS Orne), Groupement de Défense contre les maladies des Animaux de Seine-Maritime (GDMA), Groupement de Défense Sanitaire Bretagne (GDS Bretagne), Fédération nationale des Groupements de Défense Sanitaire (GDS France), Institut de l'élevage (IDELE), Allice, INRAE, metaprogram Integrated Management of Animal Health (GISA-PICSAR project), APIS-GENE and GDS France (PARADIGM project), APIS-GENE (Genomap project), and Université de Tours (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
Abstract

International audience; Mycobacterium avium subsp. paratuberculosis is the etiological agent of Johne's disease in ruminants. Here, we report the annotated draft genome sequences of 142 M. avium subsp. paratuberculosis strains that were isolated from dairy cattle in France between 2014 and 2018. The genomes of these strains were sequenced using Illumina technology.

Published
2021
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10. Genetic features of strains of Mycobacterium avium subsp. paratuberculosis circulating in the West of France deciphered by Whole-Genome Sequencing

Author

Condé, Cyril, Cochard, Thierry, Branger, Maxime, Rossignol, Marie-Noëlle, Fourichon, Christine, Delafosse, Arnaud, Davergne, Aurore, Joly, Alain, Ngwa-Mbot, David, Journaux, Laurent, Guatteo, Raphaël, Schibler, Laurent, Biet, Franck, Infectiologie et Santé Publique (UMR ISP), Université de Tours-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Génétique Animale et Biologie Intégrative (GABI), Université Paris-Saclay-AgroParisTech-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Biologie, Epidémiologie et analyse de risque en Santé Animale (BIOEPAR), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Groupement de Défense Sanitaire Orne (GDS Orne), Groupement de Défense contre les maladies des Animaux de Seine-Maritime (GDMA), Groupement de Défense Sanitaire Bretagne (GDS Bretagne), Fédération nationale des Groupements de Défense Sanitaire (GDS France), Institut de l'élevage (IDELE), Allice, Société Française de Microbiologie, and Université de Tours (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
Mycobacterium avium subsp. paratuberculosis, whole genome sequencing, pangenome, genotyping, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], phylogeny, [SDV.BID.SPT]Life Sciences [q-bio]/Biodiversity/Systematics, Phylogenetics and taxonomy
Abstract

International audience; Introduction: Paratuberculosis is a chronic infection of the intestine, mainly the ileum, caused by Mycobacterium avium subsp. paratuberculosis (Map) in cattle and other ruminants. This enzootic disease is present worldwide and has a strong impact on the dairy cattle industry. For this species, the typing tools do not make it possible to investigate the genetic diversity of the strains. These limitations can be overcome by the application of Whole Genome Sequencing (WGS), particularly for clonal populations such as Map. WGS analyses can provide comprehensive genetic information, including information on genome evolution, discrimination of closely related strains and virulence determinants.The purpose of the present study was to undertake a whole-genome analysis of Map strains to identify accurate phylogenetic relationships between isolates and establish correlations between genomic traits and epidemiologicaldata within a population of well documented-strains.Materials and methods: A set of 200 animal field strains were selected based on a previous large-scale longitudinal study representative of the French Map population circulating in the West of France. Strains were isolated from bovine of breed Prim’Holstein or Normande naturally infected by Map. For each strain isolated, all information about the animal is available including: breed, herd prevalence, locations, serological status and excretion level. The genomic sequences of Map strains were obtained by Illumina MiSeq sequencing. Genomic sequences were assessed for potential contamination using Kraken2. Cleaned reads were aligned to the reference genome K-10 and SNP were called using FreeBayes. IQ-Tree was used to infer a SNP-based phylogeny.Results, discussion and conclusion: This study provided 200 new genomes of French strains isolates from naturally infected animals. Pangenome analysis of this panel confirmed the degree of Map clonality. SNP analyzes provided accurate phylogeny able to distinguish each strain divided into 4 clusters independently of the breed of the cattle. Interestingly, the phylogeny clearly distinct the two major MLVA profiles. A phylogeny was inferred with French Map isolates and with other Map isolates found across the world. Relations between genetic traits and epidemiological data will be investigated to better understand the transmission dynamics of the disease

Published
2021

12. Impact of Host Genetics on Caecal Microbiota Composition and on Salmonella Carriage in Chicken

Author

Cazals, Anaïs, primary, ESTELLÉ, Jordi, additional, BRUNEAU, Nicolas, additional, COVILLE, Jean-Luc, additional, MENANTEAU, Pierrette, additional, ROSSIGNOL, Marie-Noëlle, additional, JARDET, Deborah, additional, BEVILACQUA, Claudia, additional, RAU, Andrea, additional, BED’HOM, Bertrand, additional, VELGE, Philippe, additional, and CALENGE, Fanny, additional

Published
2020
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13. Discovery of Predictors of Mycoplasma hyopneumoniae Vaccine Response Efficiency in Pigs: 16S rRNA Gene Fecal Microbiota Analysis

Author

Munyaka, Peris M., primary, Blanc, Fany, additional, Estellé, Jordi, additional, Lemonnier, Gaëtan, additional, Leplat, Jean-Jacques, additional, Rossignol, Marie-Noëlle, additional, Jardet, Déborah, additional, Plastow, Graham, additional, Billon, Yvon, additional, Willing, Benjamin P., additional, and Rogel-Gaillard, Claire, additional

Published
2020
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14. Characterization of Holstein and Normande whole milk miRNomes highlights breed specificities

Author

Le Guillou, Sandrine, Leduc, Arlette, Laubier, Johann, Barbey, Sarah, Rossignol, Marie-Noëlle, Lefebvre, Rachel, Marthey, Sylvain, Laloë, Denis, Le Provost, Fabienne, Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Université Paris Saclay (COmUE), Domaine expérimental animal du Pin (SEA), and Institut National de la Recherche Agronomique (INRA)

Subjects
Epigenomics, [SDV.GEN]Life Sciences [q-bio]/Genetics, [SDV]Life Sciences [q-bio], lcsh:R, Age Factors, lcsh:Medicine, food and beverages, Computational Biology, High-Throughput Nucleotide Sequencing, Breeding, Article, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, MicroRNAs, fluids and secretions, Milk, Species Specificity, Next-generation sequencing, Animals, lcsh:Q, Cattle, Gene expression, lcsh:Science, Transcriptome, Genetic Background
Abstract

International audience; The concept of milk as a healthy food has opened the way for studies on milk components, from nutrients to microRNAs, molecules with broad regulatory properties present in large quantities in milk. Characterization of these components has been performed in several species, such as humans and bovine, depending on the stages of lactation. Here, we have studied the variation in milk microRNA composition according to genetic background. Using high throughput sequencing, we have characterized and compared the milk miRNomes of Holstein and Normande cattle, dairy breeds with distinct milk production features, in order to highlight microRNAs that are essential for regulation of the lactation process. In Holstein and Normande milk, 2,038 and 2,030 microRNAs were identified, respectively, with 1,771 common microRNAs, of which 1,049 were annotated and 722 were predicted. The comparison of the milk miRNomes of two breeds allowed to highlight 182 microRNAs displaying significant differences in the abundance. They are involved in the regulation of lipid metabolism and mammary morphogenesis and development, which affects lactation. Our results provide new insights into the regulation of molecular mechanisms involved in milk production.

Published
2019
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15. Influence of genetic background to the bovine milk microRNA composition

Author

Le Guillou, Sandrine, Laubier, Johann, Leduc, Antoine, Launay, Frédéric, Barbey, Sarah, Lefebvre, Rachel, Rossignol, Marie-Noëlle, Marthey, Sylvain, Laloë, Denis, Le Provost, Fabienne, Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Université Paris Saclay (COmUE), Domaine expérimental animal du Pin (SEA), and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV.GEN]Life Sciences [q-bio]/Genetics, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

16. Correlazione tra microbiota fecale e risposta alla vaccinazione nei confronti del virus dell’infl uenza A nei suini.

Author

Borey, Marion, Blanc, Fany, Lemonnier, Gaëtan, Leplat, Jean-Jacques, Jardet, Deborah, Rossignol, Marie-Noëlle, Ravon, Laure, Billon, Yvon, Bernard, Maria, Estellé, Jordi, and Rogel-Gaillard, Claire

Abstract

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Published
2021

17. Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle

Author

Daetwyler, Hans D, Capitan, Aurélien, Pausch, Hubert, Stothard, Paul, van Binsbergen, Rianne, Brøndum, Rasmus Froberg, Liao, Xiaoping, Djari, Anis, Rodriguez, Sabrina C, Grohs, Cécile, Jung, Simone, Esquerré, Diane, Bouchez, Olivier, Gollnick, Nicole S, Rossignol, Marie-Noëlle, Klopp, Christophe, Rocha, Dominique, Fritz, Sébastien, Eggen, André, Bowman, Phil J, Coote, David, Chamberlain, Amanda J, VanTassell, Curt P, Hulsegge, Ina, Goddard, Mike E, Guldbrandtsen, Bernt, Lund, Mogens Sandø, Veerkamp, Roel F, Boichard, Didier A, Fries, Ruedi, and Hayes, Ben J

Abstract

The 1000 bull genomes project supports the goal of accelerating the rates of genetic gain in domestic cattle while at the same time considering animal health and welfare by providing the annotated sequence variants and genotypes of key ancestor bulls. In the first phase of the 1000 bull genomes project, we sequenced the whole genomes of 234 cattle to an average of 8.3-fold coverage. This sequencing includes data for 129 individuals from the global Holstein-Friesian population, 43 individuals from the Fleckvieh breed and 15 individuals from the Jersey breed. We identified a total of 28.3 million variants, with an average of 1.44 heterozygous sites per kilobase for each individual. We demonstrate the use of this database in identifying a recessive mutation underlying embryonic death and a dominant mutation underlying lethal chrondrodysplasia. We also performed genome-wide association studies for milk production and curly coat, using imputed sequence variants, and identified variants associated with these traits in cattle

Published
2014

18. Draft Anaplasma phagocytophilum Genome Sequences from Five Cows, Two Horses, and One Roe Deer Collected in Europe

Author

Dugat, Thibaud, primary, Rossignol, Marie-Noëlle, additional, Rué, Olivier, additional, Loux, Valentin, additional, Marthey, Sylvain, additional, Moroldo, Marco, additional, Silaghi, Cornelia, additional, Höper, Dirk, additional, Fröhlich, Julia, additional, Pfeffer, Martin, additional, Zweygarth, Erich, additional, Lagrée, Anne-Claire, additional, Boulouis, Henri-Jean, additional, and Haddad, Nadia, additional

Published
2016
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19. Vers l'utilisation de marqueurs moléculaires pour l'assignation des parentés en canard grâce au programme Apache

Author

Chapuis, Herve, Faugeras, Remy, Rossignol, Marie-Noëlle, Feve, Katia, Genestout, Lucie, Chantry-Darmon, Céline, Guemene, Daniel, Syndicat des Sélectionneurs Avicoles et Aquacoles Français (SYSAAF), Laboratoire d'Analyse Génétique pour les Espèces Animales (LABOGENA), Institut National de la Recherche Agronomique (INRA), Laboratoire de Génétique Cellulaire (LGC), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Unité de Recherches Avicoles (URA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], GENETIQUE ANIMALE, [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], CANARD PEKIN, [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2010

20. Implementation of marker assisted selection: practical lessons from dairy cattle

Author

Boichard, Didier, Fritz, Sebastien, Rossignol, Marie-Noëlle, Guillaume, François, Colleau, J Jacques, Druet, Tom, Station de Génétique Quantitative et Appliquée (SGQA), Institut National de la Recherche Agronomique (INRA), and Laboratoire d'Analyse Génétique pour les Espèces Animales (LABOGENA)

Subjects
bovin laitier, [SDV]Life Sciences [q-bio], dairy cattle, marker assisted selection, sélection assistée par marqueurs
Published
2006

21. Estimation de paramètres génétiques et détection de QTL liés à des caractères de fertilité mâle, de production de semence et de qualité de la semence chez le taureau laitiers

Author

Basso, Benjamin, Fritz, Sebastien, Druet, Tom, Guillaume, François, Rossignol, Marie-Noëlle, Amigues, Yves, GABRIEL, Roven, Sellem, Eli, Salas-Cortes, Laura, HUMBLOT, P., Druart, Xavier, Station de Génétique Quantitative et Appliquée (SGQA), Institut National de la Recherche Agronomique (INRA), Laboratoire d'Analyse Génétique pour les Espèces Animales (LABOGENA), Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), ProdInra, Migration, and Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV] Life Sciences [q-bio], MALE FERTILITY, QTL, [SDV]Life Sciences [q-bio], SEMEN PRODUCTION, [INFO]Computer Science [cs], [INFO] Computer Science [cs], SEMEN, DAIRY CATTLE, ComputingMilieux_MISCELLANEOUS, LOCUS A EFFETS QUANTITATIFS
Abstract

National audience

Published
2005

22. Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle

Author

Daetwyler, Hans D, primary, Capitan, Aurélien, additional, Pausch, Hubert, additional, Stothard, Paul, additional, van Binsbergen, Rianne, additional, Brøndum, Rasmus F, additional, Liao, Xiaoping, additional, Djari, Anis, additional, Rodriguez, Sabrina C, additional, Grohs, Cécile, additional, Esquerré, Diane, additional, Bouchez, Olivier, additional, Rossignol, Marie-Noëlle, additional, Klopp, Christophe, additional, Rocha, Dominique, additional, Fritz, Sébastien, additional, Eggen, André, additional, Bowman, Phil J, additional, Coote, David, additional, Chamberlain, Amanda J, additional, Anderson, Charlotte, additional, VanTassell, Curt P, additional, Hulsegge, Ina, additional, Goddard, Mike E, additional, Guldbrandtsen, Bernt, additional, Lund, Mogens S, additional, Veerkamp, Roel F, additional, Boichard, Didier A, additional, Fries, Ruedi, additional, and Hayes, Ben J, additional

Published
2014
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23. Mise en place d'une sélection assistée par marqueurs dans les trois principales races bovines laitières françaises

Author

Fritz, Sebastien, Colleau, J Jacques, Druet, Tom, Boscher, Marie Yvonne, Rossignol, Marie-Noëlle, Malafosse, A., Boichard, Didier, Station de Génétique Quantitative et Appliquée (SGQA), Institut National de la Recherche Agronomique (INRA), and Laboratoire d'Analyse Génétique pour les Espèces Animales (LABOGENA)

Subjects
bovin laitier, FEMALE FERTILITY, [SDV]Life Sciences [q-bio], qtl, QTL, DAIRY CATTLE, MARKER ASSISTED SELECTION, fertilité femelle, ComputingMilieux_MISCELLANEOUS, sélection assistée par marqueurs
Abstract

International audience

Published
2003

24. Implementation of marker-assisted selection in french dairy cattle

Author

Boichard, Didier, Fritz, Sebastien, Rossignol, Marie-Noëlle, Boscher, Marie Yvonne, Malafosse, A., Colleau, J Jacques, Station de Génétique Quantitative et Appliquée (SGQA), Institut National de la Recherche Agronomique (INRA), and Laboratoire d'Analyse Génétique pour les Espèces Animales (LABOGENA)

Subjects
bovin laitier, MARKER ASSISTED SELECTION, DAIRY CATTLE, SELECTION SCHEME, schema de sélection, [SDV]Life Sciences [q-bio], sélection assistée par marqueurs
Published
2002

25. Novel Insights into the Bovine Polled Phenotype and Horn Ontogenesis in Bovidae

Author

Allais-Bonnet, Aurélie, primary, Grohs, Cécile, additional, Medugorac, Ivica, additional, Krebs, Stefan, additional, Djari, Anis, additional, Graf, Alexander, additional, Fritz, Sébastien, additional, Seichter, Doris, additional, Baur, Aurélia, additional, Russ, Ingolf, additional, Bouet, Stéphan, additional, Rothammer, Sophie, additional, Wahlberg, Per, additional, Esquerré, Diane, additional, Hoze, Chris, additional, Boussaha, Mekki, additional, Weiss, Bernard, additional, Thépot, Dominique, additional, Fouilloux, Marie-Noëlle, additional, Rossignol, Marie-Noëlle, additional, van Marle-Köster, Este, additional, Hreiðarsdóttir, Gunnfríður Elín, additional, Barbey, Sarah, additional, Dozias, Dominique, additional, Cobo, Emilie, additional, Reversé, Patrick, additional, Catros, Olivier, additional, Marchand, Jean-Luc, additional, Soulas, Pascal, additional, Roy, Pierre, additional, Marquant-Leguienne, Brigitte, additional, Le Bourhis, Daniel, additional, Clément, Laetitia, additional, Salas-Cortes, Laura, additional, Venot, Eric, additional, Pannetier, Maëlle, additional, Phocas, Florence, additional, Klopp, Christophe, additional, Rocha, Dominique, additional, Fouchet, Michel, additional, Journaux, Laurent, additional, Bernard-Capel, Carine, additional, Ponsart, Claire, additional, Eggen, André, additional, Blum, Helmut, additional, Gallard, Yves, additional, Boichard, Didier, additional, Pailhoux, Eric, additional, and Capitan, Aurélien, additional

Published
2013
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26. A 3.7 Mb Deletion Encompassing ZEB2 Causes a Novel Polled and Multisystemic Syndrome in the Progeny of a Somatic Mosaic Bull

Author

Capitan, Aurélien, primary, Allais-Bonnet, Aurélie, additional, Pinton, Alain, additional, Marquant-Le Guienne, Brigitte, additional, Le Bourhis, Daniel, additional, Grohs, Cécile, additional, Bouet, Stéphan, additional, Clément, Laëtitia, additional, Salas-Cortes, Laura, additional, Venot, Eric, additional, Chaffaux, Stéphane, additional, Weiss, Bernard, additional, Delpeuch, Arnaud, additional, Noé, Guy, additional, Rossignol, Marie-Noëlle, additional, Barbey, Sarah, additional, Dozias, Dominique, additional, Cobo, Emilie, additional, Barasc, Harmonie, additional, Auguste, Aurélie, additional, Pannetier, Maëlle, additional, Deloche, Marie-Christine, additional, Lhuilier, Emeline, additional, Bouchez, Olivier, additional, Esquerré, Diane, additional, Salin, Gérald, additional, Klopp, Christophe, additional, Donnadieu, Cécile, additional, Chantry-Darmon, Céline, additional, Hayes, Hélène, additional, Gallard, Yves, additional, Ponsart, Claire, additional, Boichard, Didier, additional, and Pailhoux, Eric, additional

Published
2012
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28. The ß-importin KAP8 ( Pse1/ Kap121) is required for nuclear import of the cellulase transcriptional regulator XYR1, asexual sporulation and stress resistance in T richoderma reesei.

Author

Ghassemi, Sara, Lichius, Alexander, Bidard, Fréderique, Lemoine, Sophie, Rossignol, Marie‐Noëlle, Herold, Silvia, Seidl‐Seiboth, Verena, Seiboth, Bernhard, Espeso, Eduardo A., Margeot, Antoine, and Kubicek, Christian P.

Subjects
TRICHODERMA reesei, CELLULASE, GENETIC transcription regulation, XYLANASES, BACTERIAL sporulation, ASCOMYCETES, NUCLEAR pore complex
Abstract

The ascomycete T richoderma reesei is an industrial producer of cellulolytic and hemicellulolytic enzymes, and serves as a prime model for their genetic regulation. Most of its (hemi-)cellulolytic enzymes are obligatorily dependent on the transcriptional activator XYR1. Here, we investigated the nucleo-cytoplasmic shuttling mechanism that transports XYR1 across the nuclear pore complex. We identified 14 karyopherins in T . reesei, of which eight were predicted to be involved in nuclear import, and produced single gene-deletion mutants of all. We found KAP8, an ortholog of A spergillus nidulans KapI, and S accharomyces cerevisiae Kap121/ Pse1, to be essential for nuclear recruitment of GFP- XYR1 and cellulase gene expression. Transformation with the native gene rescued this effect. Transcriptomic analyses of Δ kap8 revealed that under cellulase-inducing conditions 42 CAZymes, including all cellulases and hemicellulases known to be under XYR1 control, were significantly down-regulated. Δ kap8 strains were capable of forming fertile fruiting bodies but exhibited strongly reduced conidiation both in light and darkness, and showed enhanced sensitivity towards abiotic stress, including high osmotic pressure, low pH and high temperature. Together, these data underscore the significance of nuclear import of XYR1 in cellulase and hemicellulase gene regulation in T . reesei, and identify KAP8 as the major karyopherin required for this process. [ABSTRACT FROM AUTHOR]

Published
2015
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29. Draft Genome Sequences of 142 Mycobacterium avium subsp. paratuberculosis Strains Isolated from Naturally Infected Dairy Cattle.

Author

Conde C, Branger M, Cochard T, Rossignol MN, Fourichon C, Delafosse A, Davergne A, Joly A, Ngwa-Mbot D, Journaux L, Guatteo R, Schibler L, and Biet F

Abstract

Mycobacterium avium subsp. paratuberculosis is the etiological agent of Johne's disease in ruminants. Here, we report the annotated draft genome sequences of 142 M. avium subsp. paratuberculosis strains that were isolated from dairy cattle in France between 2014 and 2018. The genomes of these strains were sequenced using Illumina technology.

Published
2021
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