98 results on '"Rossi Sebastiano D"'
Search Results
2. Giant SEPs and SEP-recovery function in Unverricht–Lundborg disease
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Visani, E., Canafoglia, L., Rossi Sebastiano, D., Agazzi, P., Panzica, F., Scaioli, V., Ciano, C., and Franceschetti, S.
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- 2013
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3. Event related desynchronization and synchronization reveals different dysfunction in SCA with respect to EPM1 patients
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Visani, E., primary, Nanetti, L., additional, Mongelli, A., additional, Panzica, F., additional, Rossi Sebastiano, D., additional, Castaldo, A., additional, Franceschetti, S., additional, Mariotti, C., additional, and Canafoglia, L., additional
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- 2019
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4. Cortical changes detected with MEG in Tourette syndrome following Δ9-tetrahydrocannabinol challenge test
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Rossi Sebastiano, D., primary, Calandrella, D., additional, Visani, E., additional, Granvillano, A., additional, Dotta, S., additional, Romito, L.M., additional, and Panzica, F., additional
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- 2019
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5. Cortical changes detected with MEG in Tourette syndrome following [formula omitted]9-tetrahydrocannabinol challenge test
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Rossi Sebastiano, D., Calandrella, D., Visani, E., Granvillano, A., Dotta, S., Romito, L.M., and Panzica, F.
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- 2019
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6. Early effect of dalfampridine in patients with MS: A multi-instrumental approach to better investigate responsiveness
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Brambilla, L., primary, Rossi Sebastiano, D., additional, Aquino, D., additional, Torri Clerici, V., additional, Brenna, G., additional, Moscatelli, M., additional, Frangiamore, R., additional, Giovannetti, A.M., additional, Antozzi, C., additional, Mantegazza, R., additional, Franceschetti, S., additional, Bruzzone, M.G., additional, Erbetta, A., additional, and Confalonieri, P., additional
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- 2016
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7. 100. Laterality indices determined by magnetoencephalography in three different temporal span may reflect better than one the complex reality of the language dominance
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Rossi Sebastiano, D., primary, Duran, D., additional, Visani, E., additional, Rotondi, F., additional, Canafoglia, L., additional, Panzica, F., additional, and Franceschetti, S., additional
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- 2016
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8. Electroclinical presentation and genotype-phenotype relationships in patients with Unverricht-Lundborg disease carrying compound heterozygous CSTB point and indel mutations
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Canafoglia, L., Gennaro, E., Capovilla, G., Gobbi, G., Boni, A., Beccaria, F., Viri, M., Michelucci, R., Agazzi, P., Assereto, S., Coviello, D. A., Di Stefano, M., Rossi Sebastiano, D., Franceschetti, S., and Zara, F.
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Adult ,Male ,Heterozygote ,Adolescent ,Messenger ,DNA Mutational Analysis ,Young Adult ,INDEL Mutation ,Unverricht-Lundborg Syndrome ,Evoked Potentials, Auditory, Brain Stem ,Humans ,Immunoprecipitation ,Point Mutation ,Absences with myoclonic components ,Compound heterozygous EPM1A ,Progressive myoclonus epilepsy ,Unverricht-Lundborg disease ,Acoustic Stimulation ,Cystatin B ,Electrodiagnosis ,Electroencephalography ,Magnetic Resonance Imaging ,Neurologic Examination ,RNA, Messenger ,Retrospective Studies ,Phenotype ,Evoked Potentials ,Auditory ,RNA ,Brain Stem - Abstract
Unverricht-Lundborg disease (EPM1A) is frequently due to an unstable expansion of a dodecamer repeat in the CSTB gene, whereas other types of mutations are rare. EPM1A due to homozygous expansion has a rather stereotyped presentation with prominent action myoclonus. We describe eight patients with five different compound heterozygous CSTB point or indel mutations in order to highlight their particular phenotypical presentations and evaluate their genotype-phenotype relationships.We screened CSTB mutations by means of Southern blotting and the sequencing of the genomic DNA of each proband. CSTB messenger RNA (mRNA) aberrations were characterized by sequencing the complementary DNA (cDNA) of lymphoblastoid cells, and assessing the protein concentrations in the lymphoblasts. The patient evaluations included the use of a simplified myoclonus severity rating scale, multiple neurophysiologic tests, and electroencephalography (EEG)-polygraphic recordings. To highlight the particular clinical features and disease time-course in compound heterozygous patients, we compared some of their characteristics with those observed in a series of 40 patients carrying the common homozygous expansion mutation observed at the C. Besta Foundation, Milan, Italy.The eight compound heterozygous patients belong to six EPM1A families (out of 52; 11.5%) diagnosed at the Laboratory of Genetics of the Galliera Hospitals in Genoa, Italy. They segregated five different heterozygous point or indel mutations in association with the common dodecamer expansion. Four patients from three families had previously reported CSTB mutations (c.67-1GC and c.168+1_18del); one had a novel nonsense mutation at the first exon (c.133CT) leading to a premature stop codon predicting a short peptide; the other three patients from two families had a complex novel indel mutation involving the donor splice site of intron 2 (c.168+2_169+21delinsAA) and leading to an aberrant transcript with a partially retained intron. The protein dose (cystatin B/β-actin) in our heterozygous patients was 0.24 ± 0.02, which is not different from that assessed in patients bearing the homozygous dodecamer expansion. The compound heterozygous patients had a significantly earlier disease onset (7.4 ± 1.7 years) than the homozygous patients, and their disease presentations included frequent myoclonic seizures and absences, often occurring in clusters throughout the course of the disease. The seizures were resistant to the pharmacologic treatments that usually lead to complete seizure control in homozygous patients. EEG-polygraphy allowed repeated seizures to be recorded. Action myoclonus progressively worsened and all of the heterozygous patients older than 30 years were in wheelchairs. Most of the patients showed moderate to severe cognitive impairment, and six had psychiatric symptoms.EPM1A due to compound heterozygous CSTB mutations presents with variable but often markedly severe and particular phenotypes. Most of our patients presented with the electroclinical features of severe epilepsy, which is unexpected in homozygous patients, and showed frequent seizures resistant to pharmacologic treatment. The presence of variable phenotypes (even in siblings) suggests interactions with other genetic factors influencing the final disease presentation.
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- 2012
9. Periodic limb movements both in non-REM and REM sleep. A response to Drs. Manconi, Ferri and Ferini-Strambi
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Allena M. 1, 2, Morrone E. 1, De Carli F. 3, Garbarino S. 4, Manfredi C. 1, Rossi-Sebastiano D. 1, and Campus C. 1
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EEG ,Delta band ,musculoskeletal, neural, and ocular physiology ,mental disorders ,NREM sleep ,REM sleep ,Cyclic alternating pattern ,Periodic limb movements ,psychological phenomena and processes - Abstract
Objective: To investigate the temporal relationship between cerebral and autonomic activities before and during periodic limb movements in NREM and REM sleep (PLMS). Methods: Patterns of EEG, cardiac and muscle activities associated with PLMS were drawn from polysomnographic recordings of 14 outpatients selected for the presence of PLMS both in NREM and REM sleep. PLMS were scored during all sleep stages from tibial EMG. Data from a bipolar EEG channel were analyzed by wavelet transform. Heart rate (HR) was evaluated from the electrocardiogram. EEG, HR and EMG activations were detected as transient increase of signal parameters and examined by analysis of variance and correlation analysis independently in NREM and REM sleep. Homologous parameters in REM and NREM sleep were compared by paired t-test. Results: The autonomic component, expressed by HR increase, took place before the motor phenomenon both in REM and NREM sleep, but it was significantly earlier during NREM. In NREM sleep, PLM onset was heralded by a significant activation of delta-EEG, followed by a progressive increase of all the other bands. No significant activations of delta EEG were found in REM sleep. HR and EEG activations positively correlated with high frequency EEG activations and negatively (in NREM) with slow frequency ones. Conclusions: Our findings suggested a heralding role for delta band only in NREM sleep and for HR during both NREM and REM sleep. Differences in EEG and HR activation between REM and NREM sleep and correlative data suggested a different modulation of the global arousal response. Significance: In this study, timefrequency analysis and advanced statistical methods enabled an accurate comparison between brain and autonomic changes associated to PLM in NREM and REM sleep providing indications about interaction between autonomic and slow and fast EEG components of arousal response.
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- 2009
10. Simultaneous Recording of fMRI end Visual Evoked Potenatials to Study Optic Neuritis in Multiple Sclerosis
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Anwar, Mn, Bonzano, Laura, ROSSI SEBASTIANO, D, Roccatagliata, Luca, Gualniera, G, Vitali, P, Sanguineti, Vittorio, Morasso, PIETRO GIOVANNI, and Bandini, F.
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- 2007
11. Variazioni dellEEG e della frequenza cardiaca associate ai movimenti periodici delle gambe durante il sonno non REM e REM
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Ferrillo F. 1, Allena M. 1, Campus C.1, Garbarino S.1, Manfredi C. 1, Morrone E. 1, Rossi Sebastiano D. 1, and De Carli F. 2
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- 2007
12. Variazioni dellattività cardiaca in relazione alla risoluzione degli eventi respiratori ostruttivi durante il sonno REM e NREM
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Ferrillo F. 1, Allena M. 1, Campus C.1, De Carli F. 2, Manfredi C. 1, Morrone E. 1, Rossi Sebastiano D. 1, and Garbarino S. 1
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- 2007
13. The visual search test: analysis of sensitivity of the global score and of the three items in mild Alzheimer’s disease
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Girtler, NICOLA GIOVANNI, Brugnolo, Andrea, De Leo, C, Dessi, B, Rossi Sebastiano, D, Baruzzi, C, Nobili, FLAVIO MARIANO, and Rodriguez, Guido
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- 2005
14. Correlazioni SPECT-neuropsicologia nella malattia di Alzheimer iniziale
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Nobili, FLAVIO MARIANO, Brugnolo, Andrea, Calvini, Piero, Copello, F, Rossi Sebastiano, D, Girtler, NICOLA GIOVANNI, Morbelli, S, Piccardo, A, Vitali, P, and Rodriguez, Guido
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- 2004
15. Integrated neurophysiological approach to Parkinson’s disease: preliminary data
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Nobili, FLAVIO MARIANO, Morbelli, S, Calvini, Piero, Brugnolo, Andrea, Girtler, NICOLA GIOVANNI, Mignone, A, Rossi Sebastiano, D, and Rodriguez, Guido
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- 2004
16. P467: Combined neurophysiological and imaging assessment of motor cortical areas in EPM1A patients
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Visani, E., primary, Canafoglia, L., additional, Rossi Sebastiano, D., additional, Contarino, V., additional, D’Incerti, L., additional, Panzica, F., additional, and Franceschetti, S., additional
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- 2014
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17. P522: MEG study of interictal epileptic spikes in patients with Rasmussen’s encephalitis assessed by magnetic source imaging
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Visani, E., primary, Duran, D., additional, Rossi Sebastiano, D., additional, Granata, T., additional, Elena, F., additional, Ragona, F., additional, Panzica, F., additional, and Franceschetti, S., additional
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- 2014
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18. Periodic limb movements both in non-REM and REM sleep. A response to Drs. Manconi, Ferri and Ferini-Strambi
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Allena, M., Morrone, E., De Carli, F., Garbarino, S., Manfredi, C., Rossi-Sebastiano, D., and Campus, C.
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- 2009
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19. P17.7 EEG, fMRI, TMS and fNIRS: a comparison of different methods for brain mapping of cortical motor hand areas
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Visani, E., primary, Rossi Sebastiano, D., additional, Gilioli, I., additional, Granvillano, A., additional, Canafoglia, L., additional, Panzica, F., additional, Cubeddu, R., additional, Torricelli, A., additional, Spinelli, L., additional, Contini, D., additional, Caffini, M., additional, Zucchelli, L., additional, Molteni, E., additional, Bianchi, A.M., additional, Cerutti, S., additional, and Franceschetti, S., additional
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- 2011
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20. P17.6 Asymmetrical functional topography of sensory and motor areas in a patient with motor and sensory impairment of the limbs
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Rossi Sebastiano, D., primary, Scaioli, V., additional, Boncoraglio, G., additional, Maccagnano, E., additional, Parati, E., additional, Curzi, S., additional, Schiaffi, E., additional, and Franceschetti, S., additional
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- 2011
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21. Music and emotion: An EEG connectivity study in patients with disorders of consciousness.
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Varotto, G., Fazio, P., Rossi Sebastiano, D., Avanzini, G., Franceschetti, S., and Panzica, F.
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Human emotion perception is a topic of great interest for both cognitive and clinical neuroscience, but its electrophysiological correlates are still poorly understood. The present study is aimed at evaluating if measures of synchronization and indexes based on graph-theory are a tool suitable to study and quantify electrophysiological changes due to emotional stimuli perception. In particular, our study is aimed at evaluating if different EEG connectivity patterns can be induced by pleasant (consonant) or unpleasant (dissonant) music, in a population of healthy subjects, and in patients with severe disorders of consciousness (DOCs), namely vegetative state (VS) patients. [ABSTRACT FROM PUBLISHER]
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- 2012
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22. Microduplication of 15q13.3 and Microdeletion of 18q21.32 in a Patient with Moyamoya Syndrome
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Sciacca Francesca Luisa, Rizzo Ambra, Bedini Gloria, Capone Fioravante, Di Lazzaro Vincenzo, Nava Sara, Acerbi Francesco, Rossi Sebastiano Davide, Binelli Simona, Faragò Giuseppe, Gioppo Andrea, Grisoli Marina, Bruzzone Maria Grazia, Ferroli Paolo, Pantaleoni Chiara, Caputi Luigi, Vela Gomez Jesus, Parati Eugenio Agostino, and Bersano Anna
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moyamoya ,genetic ,syndrome ,15q13.3 microduplication ,18q21.32 microdeletion ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Moyamoya angiopathy (MA) is a cerebrovascular disease determining a progressive stenosis of the terminal part of the internal carotid arteries (ICAs) and their proximal branches and the compensatory development of abnormal “moyamoya„ vessels. MA occurs as an isolated cerebral angiopathy (so-called moyamoya disease) or in association with various conditions (moyamoya syndromes) including several heritable conditions such as Down syndrome, neurofibromatosis type 1 and other genomic defects. Although the mechanism that links MA to these genetic syndromes is still unclear, it is believed that the involved genes may contribute to the disease susceptibility. Herein, we describe the case of a 43 years old woman with bilateral MA and peculiar facial characteristics, having a 484-kb microduplication of the chromosomal region 15q13.3 and a previously unreported 786 kb microdeletion in 18q21.32. This patient may have a newly-recognized genetic syndrome associated with MA. Although the relationship between these genetic variants and MA is unclear, our report would contribute to widening the genetic scenario of MA, in which not only genic mutation, but also genome unbalances are possible candidate susceptibility factors.
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- 2018
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23. Simultaneous recording of Vep and fMRI to study optic neuritis in multiple sclerosis
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Anwar, M. N., Bonzano, L., Rossi-Sebastiano, D., Roccatagliata, L., Gualniera, G., Vitali, P., Vittorio Sanguineti, Morasso, P., and Bandini, F.
24. Grasping the semantic of actions: a combined behavioral and MEG study
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Elisa Visani, Gioacchino Garofalo, Davide Rossi Sebastiano, Dunja Duran, Laila Craighero, Lucia Riggio, Giovanni Buccino, Visani E., Garofalo G., Rossi Sebastiano D., Duran D., Craighero L., Riggio L., and Buccino G.
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MEG (magnetoencephalography) ,Behavioral Neuroscience ,Psychiatry and Mental health ,Neuropsychology and Physiological Psychology ,Neurology ,language processing ,motor response ,semantic ,sensorimotor system ,Biological Psychiatry ,beta rhythm ,embodiment - Abstract
There is experimental evidence that the brain systems involved in action execution also play a role in action observation and understanding. Recently, it has been suggested that the sensorimotor system is also involved in language processing. Supporting results are slower response times and weaker motor-related MEG Beta band power suppression in semantic decision tasks on single action verbs labels when the stimulus and the motor response involve the same effector. Attenuated power suppression indicates decreased cortical excitability and consequent decreased readiness to act. The embodied approach forwards that the simultaneous involvement of the sensorimotor system in the processing of the linguistic content and in the planning of the response determines this language-motor interference effect. Here, in a combined behavioral and MEG study we investigated to what extent the processing of actions visually presented (i.e., pictures of actions) and verbally described (i.e., verbs in written words) share common neural mechanisms. The findings demonstrated that, whether an action is experienced visually or verbally, its processing engages the sensorimotor system in a comparable way. These results provide further support to the embodied view of semantic processing, suggesting that this process is independent from the modality of presentation of the stimulus, including language.
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- 2022
25. A comparative study on assessment procedures and metric properties of two scoring systems of the Coma Recovery Scale-Revised items: standard and modified scores
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Ambra Mara Giovannetti, Davide Sattin, Matilde Leonardi, Greta Brenna, Davide Rossi Sebastiano, Cristina Rosazza, Venusia Covelli, Anna Nigri, Dunja Duran, Ludovico Minati, Anna Bersano, Piergiorgio Lovaglio, Stefania Ferraro, Sattin, D, Lovaglio, P, Brenna, G, Covelli, V, Rossi Sebastiano, D, Duran, D, Minati, L, Giovannetti, A, Rosazza, C, Bersano, A, Nigri, A, Ferraro, S, and Leonardi, M
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Male ,030506 rehabilitation ,medicine.medical_specialty ,disorder of consciousne ,Scale (ratio) ,Psychometrics ,Cross-sectional study ,Physical Therapy, Sports Therapy and Rehabilitation ,Standard score ,Patient assessment ,03 medical and health sciences ,0302 clinical medicine ,Injury Severity Score ,Evaluation methods ,Statistics ,Medicine ,Humans ,Coma ,behavioural assessment ,behavioural assessment, disorder of consciousness, minimally conscious state, Persistent vegetative state, scoring technique ,business.industry ,Rehabilitation ,Persistent vegetative state ,Minimally conscious state ,Recovery of Function ,Middle Aged ,medicine.disease ,disorder of consciousness ,minimally conscious state ,Cross-Sectional Studies ,ROC Curve ,SECS-S/01 - STATISTICA ,scoring technique ,Female ,Physical therapy ,Metric (unit) ,medicine.symptom ,0305 other medical science ,business ,030217 neurology & neurosurgery - Abstract
Objective: The study compared the metric characteristics (discriminant capacity and factorial structure) of two different methods for scoring the items of the Coma Recovery Scale-Revised and it analysed scale scores collected using the standard assessment procedure and a new proposed method. Design: Cross sectional design/methodological study. Setting: Inpatient, neurological unit. Participants: A total of 153 patients with disorders of consciousness were consecutively enrolled between 2011 and 2013. Intervention: All patients were assessed with the Coma Recovery Scale-Revised using standard (rater 1) and inverted (rater 2) procedures. Main outcome measures: Coma Recovery Scale-Revised score, number of cognitive and reflex behaviours and diagnosis. Results: Regarding patient assessment, rater 1 using standard and rater 2 using inverted procedures obtained the same best scores for each subscale of the Coma Recovery Scale-Revised for all patients, so no clinical (and statistical) difference was found between the two procedures. In 11 patients (7.7%), rater 2 noted that some Coma Recovery Scale-Revised codified behavioural responses were not found during assessment, although higher response categories were present. A total of 51 (36%) patients presented the same Coma Recovery Scale-Revised scores of 7 or 8 using a standard score, whereas no overlap was found using the modified score. Unidimensionality was confirmed for both score systems. Conclusion: The Coma Recovery Scale Modified Score showed a higher discriminant capacity than the standard score and a monofactorial structure was also supported. The inverted assessment procedure could be a useful evaluation method for the assessment of patients with disorder of consciousness diagnosis.
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- 2017
26. Significance of multiple neurophysiological measures in patients with chronic disorders of consciousness
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Davide Rossi Sebastiano, Matilde Leonardi, Ludovico D'Incerti, Elisa Visani, Davide Sattin, Ferruccio Panzica, Silvana Franceschetti, Eugenio Parati, Fabio Rotondi, Luigi Ferini Strambi, V. Scaioli, Rossi Sebastiano, D, Panzica, F, Visani, E, Rotondi, F, Scaioli, V, Leonardi, M, Sattin, D, D'Incerti, L, Parati, E, FERINI STRAMBI, Luigi, and Franceschetti, S.
- Subjects
Adult ,Male ,medicine.medical_specialty ,Consciousness ,media_common.quotation_subject ,Audiology ,Electroencephalography ,Physiology (medical) ,medicine ,Humans ,In patient ,Psychiatry ,Evoked Potentials ,media_common ,Persistent vegetative state ,Aged ,Coma ,medicine.diagnostic_test ,Neurophysiology ,Middle Aged ,medicine.disease ,Sleep in non-human animals ,Sensory Systems ,Chronic disorders ,Neurology ,Brain Injuries ,Chronic Disease ,Consciousness Disorders ,Female ,Neurology (clinical) ,medicine.symptom ,Psychology ,Sleep - Abstract
Objective The aim of this study was to verify the value of multiple neurophysiological tests in classifying disorders of consciousness (DOCs) in patients in a chronic vegetative or minimal consciousness state categorised on the basis of the Coma Recovery Scale (CRS). Methods The study included 142 patients, all of whom underwent long (18 h) EEG-polygraphic recordings including one night. The EEG was scored using the Synek scale and sleep patterns using an arbitrary scale. Absolute total power and relative EEG power were evaluated in different frequency bands. Multimodal evoked potentials (EPs), including auditory event-related potentials, were also evaluated and scored. Results The most information came from the combined multimodal EPs and sleep EEG scores. A two-step cluster analysis based on the collected information allowed a satisfactory evaluation of DOC severity. Spectral EEG properties seemed to be significantly related to DOC classes and CRS scores, but did not seem to make any significant additional contribution to DOC classification. Conclusions Multiple electrophysiological evaluations based on EEG, sleep polygraphic recordings and multimodal EPs are helpful in assessing DOC severity and residual functioning in patients with chronic DOCs. Significance Simple electrophysiological measures that can be easily applied at patients’ bedsides can significantly contribute to the recognition of DOC severity in chronic patients surviving a severe brain injury.
- Published
- 2014
27. Premotor cortex involvement in faciobrachial dystonic seizures: A contribution from MEG-EMG study in a case of anti-LGI1 encephalitis.
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Stabile A, Canafoglia L, Deleo F, de Curtis M, Pastori C, Di Giacomo R, Didato G, Del Sole A, Duran D, Villani F, and Rossi Sebastiano D
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- Humans, Intracellular Signaling Peptides and Proteins, Proteins, Encephalitis physiopathology, Encephalitis diagnosis, Encephalitis complications, Encephalitis immunology, Male, Female, Autoantibodies blood, Middle Aged, Magnetoencephalography, Electromyography, Motor Cortex physiopathology, Seizures physiopathology
- Published
- 2024
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28. Neurophysiological markers of motor compensatory mechanisms in early Parkinson's disease.
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Passaretti M, Cilia R, Rinaldo S, Rossi Sebastiano D, Orunesu E, Devigili G, Braccia A, Paparella G, De Riggi M, van Eimeren T, Strafella AP, Lanteri P, Berardelli A, Bologna M, and Eleopra R
- Abstract
Compensatory mechanisms in Parkinson's disease are defined as the changes that the brain uses to adapt to neurodegeneration and progressive dopamine reduction. Motor compensation in early Parkinson's disease could, in part, be responsible for a unilateral onset of clinical motor signs despite the presence of bilateral nigrostriatal degeneration. Although several mechanisms have been proposed for compensatory adaptations in Parkinson's disease, the underlying pathophysiology is unclear. Here, we investigate motor compensation in Parkinson's disease by investigating the relationship between clinical signs, dopamine transporter imaging data and neurophysiological measures of the primary motor cortex (M1), using transcranial magnetic stimulation in presymptomatic and symptomatic hemispheres of patients. In this cross-sectional, multicentre study, we screened 82 individuals with Parkinson's disease. Patients were evaluated clinically in their medication OFF state using standardized scales. Sixteen Parkinson's disease patients with bilateral dopamine transporter deficit in the putamina but unilateral symptoms were included. Twenty-eight sex- and age-matched healthy controls were also investigated. In all participants, we tested cortical excitability using single- and paired-pulse techniques, interhemispheric inhibition and cortical plasticity with paired associative stimulation. Data were analysed with ANOVAs, multiple linear regression and logistic regression models. Individual coefficients of motor compensation were defined in patients based on clinical and imaging data, i.e. the motor compensation coefficient. The motor compensation coefficient includes an asymmetry score to balance motor and dopamine transporter data between the two hemispheres, in addition to a hemispheric ratio accounting for the relative mismatch between the magnitude of motor signs and dopaminergic deficit. In patients, corticospinal excitability and plasticity were higher in the presymptomatic compared with the symptomatic M1. Also, interhemispheric inhibition from the presymptomatic to the symptomatic M1 was reduced. Lower putamen binding was associated with higher plasticity and reduced interhemispheric inhibition in the presymptomatic hemisphere. The motor compensation coefficient distinguished the presymptomatic from the symptomatic hemisphere. Finally, in the presymptomatic hemisphere, a higher motor compensation coefficient was associated with lower corticospinal excitability and interhemispheric inhibition and with higher plasticity. In conclusion, the present study suggests that motor compensation involves M1-striatal networks and intercortical connections becoming more effective with progressive loss of dopaminergic terminals in the putamen. The balance between these motor networks seems to be driven by cortical plasticity., (© The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain.)
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- 2024
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29. Waxing and waning consciousness in a patient with a midbrain cavernous malformation: illustrative case.
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Mazzaglia G, Falco J, Rossi Sebastiano D, Savoldi AP, Magnani FG, Castelli A, Ferroli P, and Gemma M
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Background: Understanding the intricate relationship between consciousness and the midbrain's structures remains a significant challenge in neuroscience. Transient lesions are perfect examples of the physiological functioning mechanism of these structures., Observations: The authors present the case of a 49-year-old female who experienced a transient disorder of consciousness due to a midbrain hematoma following surgical interventions to remove a cavernous malformation in the midbrain. This case explores the interplay between the ascending reticular activating system (ARAS) and the thalamic centers, highlighting the role of structural disruptions in influencing consciousness levels. Notably, the patient's recovery correlated with the resolution of midbrain edema, reinstating normal ARAS function and consciousness., Lessons: In patients affected by midbrain lesions, edema can lead to a fluctuating neurological status, which can be difficult to diagnose. This case highlights the midbrain's crucial role in the consciousness network and the need to comprehend the intricate connections between subcortical and cortical structures for a comprehensive understanding of human consciousness. https://thejns.org/doi/10.3171/CASE2411.
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- 2024
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30. Three montages for Transcranial electric stimulation in predicting the early post-surgery outcome of the facial nerve functioning.
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Izzo MGA, Rossi Sebastiano D, Catanzaro V, Melillo Y, Togni R, Visani E, Falco J, Casali C, Gemma M, Ferroli P, Gallone A, Cazzato D, Devigili G, Alverà S, and Lanteri P
- Abstract
Objective: We assessed the Transcranial Electrical Stimulation (TES)-induced Corticobulbar-Motor Evoked Potentials (Cb-MEPs) evoked from Orbicularis Oculi (Oc) and Orbicularis Oris (Or) muscles with FCC5h/FCC6h-Mz, C3/C4-Cz and C5/C6/-Cz stimulation, during IntraOperative NeuroMonitoring (IONM) in 30 patients who underwent skull-base surgery., Methods: before (T0) and after (T1) the surgery, we compared the peak-to-peak amplitudes of Cb-MEPs obtained from TES with C3/C4-Cz, C5/C6-Cz and FCC5h/FCC6h-Mz. Then, we compared the response category (present, absent and peripheral) related to different montages. Finally, we classified the Cb-MEPs data from each patient for concordance with clinical outcome and we assessed the diagnostic measures for Cb-MEPs data obtained from FCC5h/FCC6h-Mz, C3/C4-Cz and C5/C6-Cz TES stimulation., Results: Both at T0 and T1, FCC5h/FCC6h-Mz stimulation evoked larger Cb-MEPs than C3/C4-Cz, less peripheral responses from direct activation of facial nerve than C5/C6-Cz. FCC5h/FCC6h-Mz stimulation showed the best accuracy and specificity of Cb-MEPs for clinical outcomes., Conclusions: FCC5h/FCC6h-Mz stimulation showed the best performances for monitoring the facial nerve functioning, maintaining excellent diagnostic measures even at low stimulus voltages., Significance: We demonstrated that FCC5h/FCC6h-Mz TES montage for Cb-MEPs in IONM has good accuracy in predicting the post-surgery outcome of facial nerve functioning., Competing Interests: Conflict of interests None., (Copyright © 2024 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.)
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- 2024
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31. Early occurrence of photic-reflex myoclonus in CDKL5-deficiency disorder.
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Caputo D, Franceschetti S, Canafoglia L, Iascone M, Rossi Sebastiano D, Freri E, and Granata T
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- Humans, Male, Female, Photic Stimulation methods, Genetic Diseases, X-Linked genetics, Genetic Diseases, X-Linked physiopathology, Retinal Degeneration physiopathology, Retinal Degeneration genetics, Reflex physiology, Protein Serine-Threonine Kinases genetics, Epileptic Syndromes, Spasms, Infantile, Myoclonus physiopathology, Myoclonus genetics
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- 2024
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32. Cortical Myoclonus and Complex Paroxysmal Dyskinesias in a Patient with NAA15 Variant.
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Freri E, Canafoglia L, Ciaccio C, Rossi Sebastiano D, Caputo D, Solazzi R, Sciacca FL, Iascone M, Panzica F, Granata T, Franceschetti S, and Nardocci N
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- Humans, Male, Female, Myoclonus genetics, Myoclonus physiopathology, Chorea genetics, Chorea physiopathology
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- 2024
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33. Early cortico-muscular coherence and cortical network changes in Parkinson's patients treated with MRgFUS.
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Visani E, Panzica F, Franceschetti S, Golfrè Andreasi N, Cilia R, Rinaldo S, Rossi Sebastiano D, Lanteri P, and Eleopra R
- Abstract
Introduction: To investigate cortical network changes using Magnetoencephalography (MEG) signals in Parkinson's disease (PD) patients undergoing Magnetic Resonance-guided Focused Ultrasound (MRgFUS) thalamotomy., Methods: We evaluated the MEG signals in 16 PD patients with drug-refractory tremor before and after 12-month from MRgFUS unilateral lesion of the ventralis intermediate nucleus (Vim) of the thalamus contralateral to the most affected body side. We recorded patients 24 h before (T0) and 24 h after MRgFUS (T1). We analyzed signal epochs recorded at rest and during the isometric extension of the hand contralateral to thalamotomy. We evaluated cortico-muscular coherence (CMC), the out-strength index from non-primary motor areas to the pre-central area and connectivity indexes, using generalized partial directed coherence. Statistical analysis was performed using RMANOVA and post hoc t -tests., Results: Most changes found at T1 compared to T0 occurred in the beta band and included: (1) a re-adjustment of CMC distribution; (2) a reduced out-strength from non-primary motor areas toward the precentral area; (3) strongly reduced clustering coefficient values. These differences mainly occurred during motor activation and with few statistically significant changes at rest. Correlation analysis showed significant relationships between changes of out-strength and clustering coefficient in non-primary motor areas and the changes in clinical scores., Discussion: One day after MRgFUS thalamotomy, PD patients showed a topographically reordered CMC and decreased cortico-cortical flow, together with a reduced local connection between different nodes. These findings suggest that the reordered cortico-muscular and cortical-networks in the beta band may represent an early physiological readjustment related to MRgFUS Vim lesion., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be considered as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision., (Copyright © 2024 Visani, Panzica, Franceschetti, Golfrè Andreasi, Cilia, Rinaldo, Rossi Sebastiano, Lanteri and Eleopra.)
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- 2024
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34. Brain activation during processing of mouth actions in patients with disorders of consciousness.
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Errante A, Ferraro S, Demichelis G, Pinardi C, Stanziano M, Sattin D, Rossi Sebastiano D, Rozzi S, D'Incerti L, Catricalà E, Leonardi M, Bruzzone MG, Fogassi L, and Nigri A
- Abstract
In the past 2 decades, several attempts have been made to promote a correct diagnosis and possible restorative interventions in patients suffering from disorders of consciousness. Sensory stimulation has been proved to be useful in sustaining the level of arousal/awareness and to improve behavioural responsiveness with a significant effect on oro-motor functions. Recently, action observation has been proposed as a stimulation strategy in patients with disorders of consciousness, based on neurophysiological evidence that the motor cortex can be activated not only during action execution but also when actions are merely observed in the absence of motor output, or during listening to action sounds and speech. This mechanism is provided by the activity of mirror neurons. In the present study, a group of patients with disorders of consciousness (11 males, 4 females; median age: 55 years; age range: 19-74 years) underwent task-based functional MRI in which they had, in one condition, to observe and listen to the sound of mouth actions, and in another condition, to listen to verbs with motor or abstract content. In order to verify the presence of residual activation of the mirror neuron system, the brain activations of patients were compared with that of a group of healthy individuals (seven males, eight females; median age: 33.4 years; age range: 24-65 years) performing the same tasks. The results show that brain activations were lower in patients with disorders of consciousness compared with controls, except for primary auditory areas. During the audiovisual task, 5 out of 15 patients with disorders of consciousness showed only residual activation of low-level visual and auditory areas. Activation of high-level parieto-premotor areas was present in six patients. During the listening task, three patients showed only low-level activations, and six patients activated also high-level areas. Interestingly, in both tasks, one patient with a clinical diagnosis of vegetative state showed activations of high-level areas. Region of interest analysis on blood oxygen level dependent signal change in temporal, parietal and premotor cortex revealed a significant linear relation with the level of clinical functioning, assessed with coma recovery scale-revised. We propose a classification of the patient's response based on the presence of low-level and high-level activations, combined with the patient's functional level. These findings support the use of action observation and listening as possible stimulation strategies in patients with disorders of consciousness and highlight the relevance of combined methods based on functional assessment and brain imaging to provide more detailed neuroanatomical specificity about residual activated areas at both cortical and subcortical levels., Competing Interests: The authors report no competing interests., (© The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain.)
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- 2024
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35. The effect of GPi-DBS assessed by gait analysis in DYT11 dystonia: a case study.
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Lunardini F, Satolli S, Levi V, Rossi Sebastiano D, and Zorzi GS
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- Humans, Gait Analysis, Globus Pallidus, Treatment Outcome, Dystonia therapy, Dystonic Disorders therapy, Deep Brain Stimulation
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- 2024
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36. Non-Functional Jaw Muscular Activity in Patients with Disorders of Consciousness Revealed by A Long-Lasting Polygraphy.
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Cacciatore M, Magnani FG, Ippoliti C, Barbadoro F, Anversa P, Portincaso L, Visani E, Navarro J, Devalle G, Lanfranchi M, Pingue V, Marelli S, Ferini Strambi L, Lunardini F, Ferrante S, Tremolati M, Leonardi M, Rossi Sebastiano D, and Sattin D
- Abstract
The presence of involuntary, non-functional jaw muscle activity (NFJMA) has not yet been assessed in patients with disorders of consciousness (DOC), although the presence of bruxism and other forms of movement disorders involving facial muscles is probably more frequent than believed. In this work, we evaluated twenty-two prolonged or chronic DOC patients with a long-lasting polygraphic recording to verify NFJMA occurrence and assess its neurophysiological patterns in this group of patients. A total of 5 out of 22 patients showed the presence of significant NFJMA with electromyographic patterns similar to what can be observed in non-DOC patients with bruxism, thus suggesting a disinhibition of masticatory motor nuclei from the cortical control. On the other hand, in two DOC patients, electromyographic patterns advised for the presence of myorhythmia, thus suggesting a brainstem/diencephalic involvement. Functional, non-invasive tools such as long-lasting polygraphic recordings should be extended to a larger sample of patients, since they are increasingly important in revealing disorders potentially severe and impacting the quality of life of DOC patients.
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- 2023
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37. Grasping the semantic of actions: a combined behavioral and MEG study.
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Visani E, Garofalo G, Rossi Sebastiano D, Duran D, Craighero L, Riggio L, and Buccino G
- Abstract
There is experimental evidence that the brain systems involved in action execution also play a role in action observation and understanding. Recently, it has been suggested that the sensorimotor system is also involved in language processing. Supporting results are slower response times and weaker motor-related MEG Beta band power suppression in semantic decision tasks on single action verbs labels when the stimulus and the motor response involve the same effector. Attenuated power suppression indicates decreased cortical excitability and consequent decreased readiness to act. The embodied approach forwards that the simultaneous involvement of the sensorimotor system in the processing of the linguistic content and in the planning of the response determines this language-motor interference effect. Here, in a combined behavioral and MEG study we investigated to what extent the processing of actions visually presented (i.e., pictures of actions) and verbally described (i.e., verbs in written words) share common neural mechanisms. The findings demonstrated that, whether an action is experienced visually or verbally, its processing engages the sensorimotor system in a comparable way. These results provide further support to the embodied view of semantic processing, suggesting that this process is independent from the modality of presentation of the stimulus, including language., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Visani, Garofalo, Rossi Sebastiano, Duran, Craighero, Riggio and Buccino.)
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- 2022
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38. MRI-guided focused-ultrasound thalamotomy in essential tremor: Immediate and delayed changes in cortico-muscular coherence and cortico-cortical out-strength.
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Visani E, Panzica F, Eleopra R, Rossi Sebastiano D, Lanteri P, Devigili G, Dotta S, Rinaldo S, and Franceschetti S
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- Humans, Thalamus diagnostic imaging, Thalamus surgery, Magnetic Resonance Imaging methods, Treatment Outcome, Essential Tremor diagnostic imaging, Essential Tremor surgery, Motor Cortex diagnostic imaging, Motor Cortex surgery
- Abstract
Objective: Drug-resistant essential tremor (ET) can be treated by Magnetic-Resonance-guided Focused-Ultrasound (MRgFUS) targeted to thalamic ventralis-intermediate nucleus (ViM). We are presenting the results obtained in ET patients by evaluating the cortico-muscular coherence (CMC) and the out-strength among cortical areas., Methods: We recorded MEG-EMG signals in 16 patients with predominant tremor on the right upper limb. The examination was performed the day before MRgFUS (T0) treatment, 24 hours (T1), and 3-months (T2) after lesioning the left ViM. Normalized CMC (nCMC) and cortico-cortical out-strength among cortical areas were assessed during isometric extension of the right hand., Results: According to the Essential Tremor Rating Assessment Scale, 13 of 16 patients were considered responders. At T1, in the beta-band, nCMC increased in the left hemisphere, namely in the areas directly involved in motor functions. At T2, the nCMC in non-motor areas decreased and the out-strength from other examined cortical areas toward the left motor-area decreased., Conclusions: In patients positively responding to MRgFUS, the CMC increased in the motor-area of the treated hemisphere immediately after the treatment, while the reorganization of CMC and cortico-cortical out-strength toward the cortical motor area occurred with a delay., Significance: The effective treatment with MRgFUS corresponds with a readjustment of the CMC and of the communication between cortical areas., (Copyright © 2022 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.)
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- 2022
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39. Significance and clinical suggestions for the somatosensory evoked potentials increased in amplitude revealed by a large sample of neurological patients.
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Rossi Sebastiano D, Cazzato D, Visani E, Dalla Bella E, Brambilla L, Devigili G, Caroppo P, Maggi L, Nanetti L, Salsano E, Canafoglia L, Canavero I, Anghileri E, Bonfoco D, and Lanteri P
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- Electroencephalography, Evoked Potentials, Somatosensory physiology, Humans, Median Nerve, Somatosensory Cortex physiology, Epilepsies, Myoclonic, Epilepsy, Myoclonus
- Abstract
Objectives: To investigate the relationship between N20-P25 peak-to-peak amplitude (N20p-P25p) of somatosensory evoked potentials (SEPs) and the occurrence of abnormalities of the peripheral and/or central sensory pathways and of myoclonus/epilepsy, in 308 patients with increased SEPs amplitude from upper limb stimulation., Methods: We compared cortical response (N20p-P25p) in different groups of patients identified by demographic, clinical, and neurophysiological factors and performed a cluster analysis for classifying the natural occurrence of subgroups of patients., Results: No significant differences of N20p-P25p were found among different age-dependent groups, and in patients with or without PNS/CNS abnormalities of sensory pathways, while myoclonic/epileptic patients showed higher N20p-P25p than other groups. Cluster analysis identified four clusters of patients including myoclonus/epilepsy, central sensory abnormalities, peripheral sensory abnormalities, and absence of myoclonus and sensory abnormalities., Conclusions: Increased N20p-P25p prompts different possible pathophysiological substrates: larger N20p-P25p in patients with cortical myoclonus and/or epilepsy is likely sustained by strong cortical hyperexcitability, while milder increase of N20p-P25p could be underpinned by plastic cortical changes following abnormalities of sensory pathways, or degenerative process involving the cortex. SEPs increased in amplitude cannot be considered an exclusive hallmark of myoclonus/epilepsy. Indeed, in several neurological disorders, it may represent a sign of adaptive, plastic, and/or degenerative cortical changes., (© 2022. Fondazione Società Italiana di Neurologia.)
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- 2022
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40. EEG Power spectra and subcortical pathology in chronic disorders of consciousness.
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Lutkenhoff ES, Nigri A, Rossi Sebastiano D, Sattin D, Visani E, Rosazza C, D'Incerti L, Bruzzone MG, Franceschetti S, Leonardi M, Ferraro S, and Monti MM
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- Atrophy, Brain diagnostic imaging, Brain pathology, Cross-Sectional Studies, Electroencephalography, Humans, Magnetic Resonance Imaging methods, Brain Injuries pathology, Consciousness
- Abstract
Background: Despite a growing understanding of disorders of consciousness following severe brain injury, the association between long-term impairment of consciousness, spontaneous brain oscillations, and underlying subcortical damage, and the ability of such information to aid patient diagnosis, remains incomplete., Methods: Cross-sectional observational sample of 116 patients with a disorder of consciousness secondary to brain injury, collected prospectively at a tertiary center between 2011 and 2013. Multimodal analyses relating clinical measures of impairment, electroencephalographic measures of spontaneous brain activity, and magnetic resonance imaging data of subcortical atrophy were conducted in 2018., Results: In the final analyzed sample of 61 patients, systematic associations were found between electroencephalographic power spectra and subcortical damage. Specifically, the ratio of beta-to-delta relative power was negatively associated with greater atrophy in regions of the bilateral thalamus and globus pallidus (both left > right) previously shown to be preferentially atrophied in chronic disorders of consciousness. Power spectrum total density was also negatively associated with widespread atrophy in regions of the left globus pallidus, right caudate, and in the brainstem. Furthermore, we showed that the combination of demographics, encephalographic, and imaging data in an analytic framework can be employed to aid behavioral diagnosis., Conclusions: These results ground, for the first time, electroencephalographic presentation detected with routine clinical techniques in the underlying brain pathology of disorders of consciousness and demonstrate how multimodal combination of clinical, electroencephalographic, and imaging data can be employed in potentially mitigating the high rates of misdiagnosis typical of this patient cohort.
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- 2022
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41. Resting-State fMRI in Chronic Patients with Disorders of Consciousness: The Role of Lower-Order Networks for Clinical Assessment.
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Medina JP, Nigri A, Stanziano M, D'Incerti L, Sattin D, Ferraro S, Rossi Sebastiano D, Pinardi C, Marotta G, Leonardi M, Bruzzone MG, and Rosazza C
- Abstract
Resting-state fMRI (rs-fMRI) is a widely used technique to investigate the residual brain functions of patients with Disorders of Consciousness (DoC). Nonetheless, it is unclear how the networks that are more associated with primary functions, such as the sensory-motor, medial/lateral visual and auditory networks, contribute to clinical assessment. In this study, we examined the rs-fMRI lower-order networks alongside their structural MRI data to clarify the corresponding association with clinical assessment. We studied 109 chronic patients with DoC and emerged from DoC with structural MRI and rs-fMRI: 65 in vegetative state/unresponsive wakefulness state (VS/UWS), 34 in minimally conscious state (MCS) and 10 with severe disability. rs-fMRI data were analyzed with independent component analyses and seed-based analyses, in relation to structural MRI and clinical data. The results showed that VS/UWS had fewer networks than MCS patients and the rs-fMRI activity in each network was decreased. Visual networks were correlated to the clinical status, and in cases where no clinical response occurred, rs-fMRI indicated distinctive networks conveying information in a similar way to other techniques. The information provided by single networks was limited, whereas the four networks together yielded better classification results, particularly when the model included rs-fMRI and structural MRI data (AUC = 0.80). Both quantitative and qualitative rs-fMRI analyses yielded converging results; vascular etiology might confound the results, and disease duration generally reduced the number of networks observed. The lower-order rs-fMRI networks could be used clinically to support and corroborate visual function assessments in DoC.
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- 2022
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42. Entropy Metrics Correlating with Higher Residual Functioning in Patients with Chronic Disorders of Consciousness.
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Visani E, Luria G, Sattin D, Rossi Sebastiano D, Ferraro S, Panzica F, Leonardi M, and Franceschetti S
- Abstract
To test the ability of different entropy measures to classify patients with different conditions of chronic disorder of consciousness, we applied the Lempel-Ziv complexity, the amplitude coalition entropy (ACE), and the synchrony coalition entropy (SCE) to the EEG signals recorded in 32 patients, clinically evaluated using the coma recovery scale revised (CRS-R). All the entropy measures indicated that differences found in the theta and alpha bands can distinguish patients in a minimal consciousness state (MCS) with respect to those in a vegetative state/unresponsive wakefulness state (VS/UWS). These differences were significant comparing the entropy measure performed on the anterior region of the left hemisphere and midline region. The values of theta-alpha entropy positively correlated with those of the CRS-R scores. Among the entropy measures, ACE most often highlighted significant differences. The higher values found in MCS were for the less impaired patients, according to their CRS-R, suggest that the preservation of signal entropy on the anterior region of the dominant hemisphere correlates with better preservation of consciousness, even in chronic conditions.
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- 2022
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43. COVID-19 outbreak in Italy: estimation of reproduction numbers over 2 months prior to phase 2.
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Allieta M, Allieta A, and Rossi Sebastiano D
- Abstract
Purpose: Two months after its first COVID-19 case, Italy counted more than 190,000 confirmed positive cases. From the beginning of April 2020, the nationwide lockdown started to show early effects by reducing the total cumulative incidence reached by the epidemic wave. Here we provide the reproduction number estimation both in space and in time from February 24 to April 24, 2020 over 2 months into the epidemic., Methods: The aim of the present work was to provide a systematical mapping of the SARS-CoV-2 transmission dynamics spread to all regions of Italy. To do so, we estimated the basic reproduction number ( R
0 ), by using the maximum likelihood estimation method in the early stage of the epidemic. In addition, we determined time evolution of this parameter across the 2 months of the observational period. Finally, we linked Rt , with two indices, the first representing the number of contagious people and the latter the density of susceptibiltiy to infection of people in a region as recorded on April 24, 2020., Results: Our estimates suggest a basic reproduction number averaged over all the regions of 3.29. Based on the SARS-CoV-2 transmission dynamics reported here, we gave a quantitative evaluation of the efficiency of the government measures to lower the reproduction number below 1 (control regime). We estimated that the worst-hit regions in Italy reached the control regime level ( Rt < 1) in about a month., Conclusion: Our work was carried out in the period between April and July,2020. We found that the mean value of time to reach the control regime across the whole country was about 31 days from February 24, 2020. Moreover, we highlighted the interplay between the reproduction number and two epidemiological/demographic indices to evaluate the "state of activity" of the epidemic, potentially helping in challenging decisions to continue, ease, or tighten restrictions., Supplementary Information: The online version contains supplementary material available at 10.1007/s10389-021-01567-1., Competing Interests: Conflict of interestThe authors declared that they have no conflict of interest., (© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.)- Published
- 2022
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44. Sleep Treatments in Disorders of Consciousness: A Systematic Review.
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Cacciatore M, Magnani FG, Leonardi M, Rossi Sebastiano D, and Sattin D
- Abstract
Sleep disorders are among the main comorbidities in patients with a Disorder of Consciousness (DOC). Given the key role of sleep in neural and cognitive functioning, detecting and treating sleep disorders in DOCs might be an effective therapeutic strategy to boost consciousness recovery and levels of awareness. To date, no systematic reviews have been conducted that explore the effect of sleep treatments in DOCs; thus, we systematically reviewed the existing studies on both pharmacological and non-pharmacological treatments for sleep disorders in DOCs. Among 2267 assessed articles, only 7 were included in the systematic review. The studies focused on two sleep disorder categories (sleep-related breathing disorders and circadian rhythm dysregulation) treated with both pharmacological (Modafinil and Intrathecal Baclofen) and non-pharmacological (positive airway pressure, bright light stimulation, and central thalamic deep brain stimulation) interventions. Although the limited number of studies and their heterogeneity do not allow generalized conclusions, all the studies highlighted the effectiveness of treatments on both sleep disorders and levels of awareness. For this reason, clinical and diagnostic evaluations able to detect sleep disorders in DOC patients should be adopted in the clinical routine for the purpose of intervening promptly with the most appropriate treatment.
- Published
- 2021
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45. Analyzing the Loss and the Recovery of Consciousness: Functional Connectivity Patterns and Changes in Heart Rate Variability During Propofol-Induced Anesthesia.
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Sattin D, Duran D, Visintini S, Schiaffi E, Panzica F, Carozzi C, Rossi Sebastiano D, Visani E, Tobaldini E, Carandina A, Citterio V, Magnani FG, Cacciatore M, Orena E, Montano N, Caldiroli D, Franceschetti S, Picozzi M, and Matilde L
- Abstract
The analysis of the central and the autonomic nervous systems (CNS, ANS) activities during general anesthesia (GA) provides fundamental information for the study of neural processes that support alterations of the consciousness level. In the present pilot study, we analyzed EEG signals and the heart rate (HR) variability (HRV) in a sample of 11 patients undergoing spinal surgery to investigate their CNS and ANS activities during GA obtained with propofol administration. Data were analyzed during different stages of GA: baseline, the first period of anesthetic induction, the period before the loss of consciousness, the first period after propofol discontinuation, and the period before the recovery of consciousness (ROC). In EEG spectral analysis, we found a decrease in posterior alpha and beta power in all cortical areas observed, except the occipital ones, and an increase in delta power, mainly during the induction phase. In EEG connectivity analysis, we found a significant increase of local efficiency index in alpha and delta bands between baseline and loss of consciousness as well as between baseline and ROC in delta band only and a significant reduction of the characteristic path length in alpha band between the baseline and ROC. Moreover, connectivity results showed that in the alpha band there was mainly a progressive increase in the number and in the strength of incoming connections in the frontal region, while in the beta band the parietal region showed mainly a significant increase in the number and in the strength of outcoming connections values. The HRV analysis showed that the induction of anesthesia with propofol was associated with a progressive decrease in complexity and a consequent increase in the regularity indexes and that the anesthetic procedure determined bradycardia which was accompanied by an increase in cardiac sympathetic modulation and a decrease in cardiac parasympathetic modulation during the induction. Overall, the results of this pilot study showed as propofol-induced anesthesia caused modifications on EEG signal, leading to a "rebalance" between long and short-range cortical connections, and had a direct effect on the cardiac system. Our data suggest interesting perspectives for the interactions between the central and autonomic nervous systems for the modulation of the consciousness level., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Sattin, Duran, Visintini, Schiaffi, Panzica, Carozzi, Rossi Sebastiano, Visani, Tobaldini, Carandina, Citterio, Magnani, Cacciatore, Orena, Montano, Caldiroli, Franceschetti, Picozzi and Matilde.)
- Published
- 2021
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46. EEG Assessment in Patients With Disorders of Consciousness: Aims, Advantages, Limits, and Pitfalls.
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Rossi Sebastiano D, Varotto G, Sattin D, and Franceschetti S
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This study presents a brief review of literature exploring simple EEG-polygraphic examinations and procedures that can be carried out at a patient's bedside. These include EEG with a common electrode array and sleep evaluation. The review briefly discusses more complex analytical techniques, such as the application of advanced EEG signal processing methods developed by our research group, to define what type of consistent markers are suitable for clinical use or to better understand complex patient conditions. These advanced analytical techniques aim to detect relevant EEG-based markers that could be useful in evaluating patients and predicting outcomes. These data could contribute to future developments in research., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Rossi Sebastiano, Varotto, Sattin and Franceschetti.)
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- 2021
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47. Visual fixation in disorders of consciousness: Development of predictive models to support differential diagnosis.
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Sattin D, Rossi Sebastiano D, Magnani FG, D'Incerti L, Marotta G, Benti R, Tirelli S, Bersano A, Duran D, Visani E, Ferraro S, Minati L, Nigri A, Rosazza C, Bianchi Marzoli S, Ciasca P, Carcagni A, Bruzzone MG, Franceschetti S, Leonardi M, and Guido D
- Subjects
- Diagnosis, Differential, Fixation, Ocular, Humans, Persistent Vegetative State diagnosis, Consciousness, Evoked Potentials, Visual
- Abstract
The visual fixation represents a doubtful behavioral sign to discriminate Vegetative from Minimally Conscious State (MCS). To disentangle its meaning, we fitted univariate and multivariable logistic regression models matching different neurophysiological and neuroimaging data of 54 patients with Disorders of Consciousness to select the best model predicting which visual performance (visual blink or pursuit) was shown by patients and the best predictors set. The best models found highlighted the importance of the structural MRI and the visual evoked potentials data in predicting visual pursuit. Then, a qualitative pilot test was made on four patients showing visual fixation revealing that the obtained models correctly predict whether the patients' visual performance could support/correlate to a cognitively mediated behavior. The present pilot models could help clinicians to evaluate if the visual fixation response can support the MCS diagnosis., (Copyright © 2021 Elsevier Inc. All rights reserved.)
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- 2021
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48. Corrigendum: Preservation of Language Processing and Auditory Performance in Patients With Disorders of Consciousness: A Multimodal Assessment.
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Ferraro S, Nigri A, D'Incerti L, Rosazza C, Sattin D, Rossi Sebastiano D, Visani E, Duran D, Marotta G, Demichelis G, Catricala' E, Kotz S, Verga L, Leonardi M, Cappa S, and Bruzzone MG
- Abstract
[This corrects the article DOI: 10.3389/fneur.2020.526465.]., (Copyright © 2021 Ferraro, Nigri, D'Incerti, Rosazza, Sattin, Rossi Sebastiano, Visani, Duran, Marotta, Demichelis, Catricala', Kotz, Verga, Leonardi, Cappa and Bruzzone.)
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- 2021
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49. Preservation of Language Processing and Auditory Performance in Patients With Disorders of Consciousness: A Multimodal Assessment.
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Ferraro S, Nigri A, D'Incerti L, Rosazza C, Sattin D, Rossi Sebastiano D, Visani E, Duran D, Marotta G, Demichelis G, Catricala' E, Kotz S, Verga L, Leonardi M, Cappa S, and Bruzzone MG
- Abstract
The impact of language impairment on the clinical assessment of patients suffering from disorders of consciousness (DOC) is unknown or underestimated and may mask the presence of conscious behavior. In a group of DOC patients ( n = 11; time post-injury range: 5-252 months), we investigated the main neural functional and structural underpinnings of linguistic processing, and their relationship with the behavioral measures of the auditory function using the Coma Recovery Scale-Revised (CRS-R). We assessed the integrity of the brainstem auditory pathways, of the left superior temporal gyrus and arcuate fasciculus, the neural activity elicited by passive listening of an auditory language task, and the mean hemispheric glucose metabolism. Our results support the hypothesis of a relationship between the level of preservation of the investigated structures/functions and the CRS-R auditory subscale scores. Moreover, our findings indicate that patients in minimally conscious state minus (MCS-): (1) when presenting the auditory startle (at the CRS-R auditory subscale) might be aphasic in the receptive domain, being severely impaired in the core language structures/functions; (2) when presenting the localization to sound might retain language processing, being almost intact or intact in the core language structures/functions. Despite the small group of investigated patients, our findings provide a grounding of the clinical measures of the CRS-R auditory subscale in the integrity of the underlying auditory structures/functions. Future studies are needed to confirm our results that might have important consequences for the clinical practice., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2020 Ferraro, Nigri, D'Incerti, Rosazza, Sattin, Rossi Sebastiano, Visani, Duran, Marotta, Demichelis, Catricala', Kotz, Verga, Leonardi, Cappa and Bruzzone.)
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- 2020
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50. Sleep in disorders of consciousness: diagnostic, prognostic, and therapeutic considerations.
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Gottshall JL and Rossi Sebastiano D
- Subjects
- Consciousness Disorders physiopathology, Electroencephalography, Humans, Prognosis, Wakefulness physiology, Brain physiopathology, Consciousness physiology, Consciousness Disorders diagnosis, Sleep physiology
- Abstract
Purpose of Review: Sleep is important in the evaluation of patients with disorders of consciousness (DOC). However, it remains unclear whether reconstitution of sleep could enable consciousness or vice versa. Here we synthesize recent evidence on natural recovery of sleep in DOC, and sleep-promoting therapeutic interventions for recovery of consciousness., Recent Findings: In subacute DOC, physiological sleep--wake cycles and complex sleep patterns are related to better outcomes. Moreover, structured rapid-eye-movement (REM), non-REM (NREM) stages, and presence of sleep spindles correlate with full or partial recovery. In chronic DOC, sleep organization may reflect both integrity of consciousness-supporting brain networks and engagement of those networks during wakefulness. Therapeutic strategies have integrated improvement of sleep and sleep--wake cycles in DOC patients; use of bright light stimulation or drugs enhancing sleep and/or vigilance, treatment of sleep apneas, and neuromodulatory stimulations are promising tools to promote healthy sleep architecture and wakeful recovery., Summary: Sleep features and sleep--wake cycles are important prognostic markers in subacute DOC and can provide insight into covert recovery in chronic DOC. Although large-scale studies are needed, preliminary studies in limited patients suggest that therapeutic options restoring sleep and/or sleep--wake cycles may improve cognitive function and outcomes in DOC.
- Published
- 2020
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