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863 results on '"Rossi, Chiara"'

12. Tissue fluidification promotes a cGAS–STING cytosolic DNA response in invasive breast cancer

Author

Frittoli, Emanuela, Palamidessi, Andrea, Iannelli, Fabio, Zanardi, Federica, Villa, Stefano, Barzaghi, Leonardo, Abdo, Hind, Cancila, Valeria, Beznoussenko, Galina V., Della Chiara, Giulia, Pagani, Massimiliano, Malinverno, Chiara, Bhattacharya, Dipanjan, Pisati, Federica, Yu, Weimiao, Galimberti, Viviana, Bonizzi, Giuseppina, Martini, Emanuele, Mironov, Alexander A., Gioia, Ubaldo, Ascione, Flora, Li, Qingsen, Havas, Kristina, Magni, Serena, Lavagnino, Zeno, Pennacchio, Fabrizio Andrea, Maiuri, Paolo, Caponi, Silvia, Mattarelli, Maurizio, Martino, Sabata, d’Adda di Fagagna, Fabrizio, Rossi, Chiara, Lucioni, Marco, Tancredi, Richard, Pedrazzoli, Paolo, Vecchione, Andrea, Petrini, Cristiano, Ferrari, Francesco, Lanzuolo, Chiara, Bertalot, Giovanni, Nader, Guilherme, Foiani, Marco, Piel, Matthieu, Cerbino, Roberto, Giavazzi, Fabio, Tripodo, Claudio, and Scita, Giorgio

Published
2023
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13. Concordance of immunohistochemistry for predictive and prognostic factors in breast cancer between biopsy and surgical excision: a single-centre experience and review of the literature

Author

Rossi, Chiara, Fraticelli, Sara, Fanizza, Marianna, Ferrari, Alberta, Ferraris, Elisa, Messina, Alessia, Della Valle, Angelica, Anghelone, Chiara Annunziata Pasqualina, Lasagna, Angioletta, Rizzo, Gianpiero, Perrone, Lorenzo, Sommaruga, Maria Grazia, Meloni, Giulia, Dallavalle, Silvia, Bonzano, Elisabetta, Paulli, Marco, Di Giulio, Giuseppe, Sgarella, Adele, and Lucioni, Marco

Published
2023
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15. Molecular insights into RmcA-mediated c-di-GMP consumption: Linking redox potential to biofilm morphogenesis in Pseudomonas aeruginosa

Author

Scribani Rossi, Chiara, Eckartt, Kelly, Scarchilli, Elisabetta, Angeli, Simone, Price-Whelan, Alexa, Di Matteo, Adele, Chevreuil, Maelenn, Raynal, Bertrand, Arcovito, Alessandro, Giacon, Noah, Fiorentino, Francesco, Rotili, Dante, Mai, Antonello, Espinosa-Urgel, Manuel, Cutruzzolà, Francesca, Dietrich, Lars E.P., Paone, Alessio, Paiardini, Alessandro, and Rinaldo, Serena

Published
2023
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20. MEM-AV: A VR-Based Approach to Improve Autobiographical Memory Retrieval in Addiction

Author

Frisone, Fabio, Calabrò, Gabriella, Rossi, Chiara, Riva, Giuseppe, Frisone, Fabio (ORCID:0000-0002-1766-831X), Rossi, Chiara (ORCID:0000-0002-3570-2710), Riva, Giuseppe (ORCID:0000-0003-3657-106X), Frisone, Fabio, Calabrò, Gabriella, Rossi, Chiara, Riva, Giuseppe, Frisone, Fabio (ORCID:0000-0002-1766-831X), Rossi, Chiara (ORCID:0000-0002-3570-2710), and Riva, Giuseppe (ORCID:0000-0003-3657-106X)

Abstract

The study of autobiographical memories (AMs)—that are intimately tied to one’s personal history—has been explored in populations suffering from addiction. Existing research suggests that individuals with addiction face similar challenges to those with other mental disorders when attempting to retrieve their AMs, often encountering memories that are uncomfortable.1 In particular, patients in drug rehabilitation centers are reluctant to share their memories, in part due to fear of stigma and potential legal repercussions. This concern fosters a heightened state of vigilance that inhibits the spontaneous sharing of personal experiences. In addition, a pervasive distrust of psychotherapists and caregivers, especially at the beginning of the rehabilitation journey, further hinders the development of autobiographical awareness—a key element for mental health improvement.

Published
2024

21. Harmonizing Emotions: Assessing Implicit and Explicit Emotional Responses in Elderly through Music Therapy Sessions

Author

Rossi, Chiara, Brazzelli, Matteo, Oasi, Osmano, Riva, Giuseppe, Rossi, Chiara (ORCID:0000-0002-3570-2710), Oasi, Osmano (ORCID:0000-0003-2134-397X), Riva, Giuseppe (ORCID:0000-0003-3657-106X), Rossi, Chiara, Brazzelli, Matteo, Oasi, Osmano, Riva, Giuseppe, Rossi, Chiara (ORCID:0000-0002-3570-2710), Oasi, Osmano (ORCID:0000-0003-2134-397X), and Riva, Giuseppe (ORCID:0000-0003-3657-106X)

Abstract

The music therapy process and its effects on the intersubjective and emotional dimensions of the elderly population are underexplored topics in the scientific literature. Intersubjectivity refers to the shared experience of being together with another person, which can influence the emotional and psychological well-being of both parties. Music therapy can facilitate intersubjectivity by creating a musical dialogue that reflects and resonates with the emotional states and needs of the participants. This can be especially beneficial for elderly and institutionalized patients, who often suffer from social isolation, loneliness, and depression. However, there is a lack of empirical evidence on how intersubjective music therapy affects the emotional dimensions and psychological well-being of this population. Therefore, there is a need for an exploratory study that examines the patient–music therapist dyad interaction, which could provide valuable insights for future research in this direction. The aim of this study is to investigate the effects of intersubjective music therapy on the emotional dimensions and psychological well-being of elderly and institutionalized patients in an assisted living facility. The study has three specific objectives: (a) to evaluate the emotional dimensions of the patients during music therapy sessions, using facial expressions as indicators of their affective states; (b) to assess the degree of attunement and activation between the patient and the music therapist, using behavioral and physiological measures of synchrony and arousal; (c) to examine the effects of the music therapy intervention on the emotional and psychological dimensions of the patients, using self-report and standardized scales of well-being, mood, and quality of life. The study will use a pre/post design, with 4 weeks of music therapy intervention, and will compare the results of the experimental group with a control group that will receive a nonmusical intervention. The s

Published
2024

26. SIMPSON-GOLABI-BEHMEL syndrome type 1: How placental immunohistochemistry can rapidly Predict the diagnosis

Author

Fiandrino, Giacomo, Arossa, Alessia, Ghirardello, Stefano, Kalantari, Silvia, Rossi, Chiara, Bonasoni, Maria Paola, Cesari, Stefania, Rizzuti, Tommaso, Giorgio, Elisa, Bassanese, Francesco, Scatigno, Annachiara Licia, Meroni, Anna, Melito, Chiara, Feltri, Monica, Longo, Stefania, Figar, Tiziana Angelica, Andorno, Annalisa, Gelli, Maria Carolina, Bertozzi, Mirko, Spinillo, Arsenio, Riccipetitoni, Giovanna, Valente, Enza Maria, Paulli, Marco, and Sirchia, Fabio

Published
2022
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29. Rethinking treatment failures. Research on a group of Italian psychotherapists.

Author

Oasi, Osmano, De Salve, Francesca, Rossi, Chiara, Maggio, Simone, Casabona, Ilaria, and Molgora, Sara

Subjects
TERMINATION of treatment, PATIENT dropouts, PSYCHOTHERAPISTS, FAILURE (Psychology), TREATMENT failure, COUNTERTRANSFERENCE (Psychology)
Abstract

Introduction: Psychotherapeutic failures involve situational, relational, and personal factors. Dropout refers to a patient's unilateral termination of treatment without the therapist's knowledge or approval. Premature termination occurs when therapy is discontinued before achieving a sufficient reduction in initial problems. Objective: This study explores the role of therapist's emotional response (countertransference), gender, psychotherapeutic orientation, and patient diagnosis in the context of psychotherapeutic failures. Method: A mixed-method approach was used. Fifty-nine Italian psychotherapists, practicing mostly privately with at least 5 years of experience, were recruited through Italian professional internet websites. The Therapist Response Questionnaire and the Impasse Interview were administered to each psychotherapist. Each therapist was asked to reflect on their last dropout patient. Quantitative (MANOVA) and qualitative analyses (textual content analysis) were conducted with SPSS and T-LAB, respectively. Results: The quantitative analyses revealed that the most frequent countertransference response was Helpless/Inadequate, with female therapists experiencing this more frequently than male therapists. The qualitative analyses identified two main factors explaining most of the variance in countertransference responses: Parental/Protective versus Hostile/Angry, and Positive/Satisfying versus Helpless/Inadequate, with Helpless/Inadequate central. Additionally, the qualitative analysis of treatment interruption methods revealed two factors explaining over 50% of the variance. Lack of communication was linked to negative themes, while mediated and direct communication were associated with positive terms. Direct communication was characterized as useful, while mediated communication was linked to dropout and attachment figures. Conclusion: Under pressure, psychotherapists' anxiety levels increase, often managed ambivalently or avoidantly. These results suggest that awareness of psychotherapist emotional responses is important to limit psychotherapeutic failures. These findings offer valuable insights for clinical practice. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Challenges and Opportunities in the Sustainable Improvement of Carrot Production.

Author

Paparella, Antonello, Kongala, Prasada Rao, Serio, Annalisa, Rossi, Chiara, Shaltiel-Harpaza, Liora, Husaini, Amjad M., and Ibdah, Mwafaq

Subjects
NUTRITION, ROOT crops, SUSTAINABILITY, PLANT health, AGRICULTURE, CARROTS
Abstract

From an agricultural perspective, carrots are a significant tap root vegetable crop in the Apiaceae family because of their nutritional value, health advantages, and economic importance. The edible part of a carrot, known as the storage root, contains various beneficial compounds, such as carotenoids, anthocyanins, dietary fiber, vitamins, and other nutrients. It has a crucial role in human nutrition as a significant vegetable and raw material in the nutraceutical, food, and pharmaceutical industries. The cultivation of carrot fields is susceptible to a wide range of biotic and abiotic hazards, which can significantly damage the plants' health and decrease yield and quality. Scientific research mostly focuses on important biotic stressors, including pests, such as nematodes and carrot flies, as well as diseases, such as cavity spots, crown or cottony rot, black rot, and leaf blight, caused by bacteria, fungi, and oomycetes. The emerging challenges in the field include gaining a comprehensive understanding of the interaction between hosts and pathogens in the carrot–pathogen system, identifying the elements that contribute to disease development, expanding knowledge of systemic treatments, exploring host resistance mechanisms, developing integrated control programs, and enhancing resistance through breeding approaches. In fact, the primary carrot-growing regions in tropical and subtropical climates are experiencing abiotic pressures, such as drought, salinity, and heat stress, which limit carrot production. This review provides an extensive, up-to-date overview of the literature on biotic and abiotic factors for enhanced and sustainable carrot production, considering the use of different technologies for the shelf-life extension of carrots. Therefore, it addresses the current issues in the carrot production chain, opening new perspectives for the exploration of carrots both as a food commodity and as a source of natural compounds. [ABSTRACT FROM AUTHOR]

Published
2024
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37. miR-21 antagonism reprograms macrophage metabolism and abrogates chronic allograft vasculopathy

Author

Usuelli, Vera, Ben Nasr, Moufida, D’Addio, Francesca, Liu, Kaifeng, Vergani, Andrea, El Essawy, Basset, Yang, Jun, Assi, Emma, Uehara, Mayuko, Rossi, Chiara, Solini, Anna, Capobianco, Annalisa, Rigamonti, Elena, Potena, Luciano, Venturini, Massimo, Sabatino, Mario, Bottarelli, Lorena, Ammirati, Enrico, Frigerio, Maria, Castillo-Leon, Eduardo, Maestroni, Anna, Azzoni, Cinzia, Loretelli, Cristian, Joe Seelam, Andy, Tai, Albert K., Pastore, Ida, Becchi, Gabriella, Corradi, Domenico, Visner, Gary A., Zuccotti, Gian V., Chau, Nelson B., Abdi, Reza, Pezzolesi, Marcus G., and Fiorina, Paolo

Published
2021
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39. Author Correction: Tissue fluidification promotes a cGAS–STING cytosolic DNA response in invasive breast cancer

Author

Frittoli, Emanuela, Palamidessi, Andrea, Iannelli, Fabio, Zanardi, Federica, Villa, Stefano, Barzaghi, Leonardo, Abdo, Hind, Cancila, Valeria, Beznoussenko, Galina V., Della Chiara, Giulia, Pagani, Massimiliano, Malinverno, Chiara, Bhattacharya, Dipanjan, Pisati, Federica, Yu, Weimiao, Galimberti, Viviana, Bonizzi, Giuseppina, Martini, Emanuele, Mironov, Alexander A., Gioia, Ubaldo, Ascione, Flora, Li, Qingsen, Havas, Kristina, Magni, Serena, Lavagnino, Zeno, Pennacchio, Fabrizio Andrea, Maiuri, Paolo, Caponi, Silvia, Mattarelli, Maurizio, Martino, Sabata, d’Adda di Fagagna, Fabrizio, Rossi, Chiara, Lucioni, Marco, Tancredi, Richard, Pedrazzoli, Paolo, Vecchione, Andrea, Petrini, Cristiano, Ferrari, Francesco, Lanzuolo, Chiara, Bertalot, Giovanni, Nader, Guilherme, Foiani, Marco, Piel, Matthieu, Cerbino, Roberto, Giavazzi, Fabio, Tripodo, Claudio, and Scita, Giorgio

Published
2023
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41. An analog to digital converter in a SiC CMOS technology for high-temperature applications

Author

Mo, J. (author), Niu, Yunfan (author), May, Alexander (author), Rommel, Mathias (author), Rossi, Chiara (author), Romijn, J. (author), Zhang, Kouchi (author), Vollebregt, S. (author), Mo, J. (author), Niu, Yunfan (author), May, Alexander (author), Rommel, Mathias (author), Rossi, Chiara (author), Romijn, J. (author), Zhang, Kouchi (author), and Vollebregt, S. (author)

Abstract

Integrated circuits based on wide bandgap semiconductors are considered an attractive option for meeting the demand for high-temperature electronics. Here, we report an analog-to-digital converter fabricated in a silicon carbide complementary metal-oxide-semiconductor technology now available through Europractice. The MOSFET component in this technology was measured up to 500 °C, and the key parameters, such as threshold voltage, field-effect mobility, and channel-length modulation parameters, were extracted. A 4-bit flash data converter, consisting of 266 transistors, is implemented with this technology and demonstrates correct operation up to 400 °C. Finally, the gate oxide quality is investigated by time-dependent dielectric breakdown measurements at 500 °C. A field-acceleration factor of 4.4 dec/(MV/cm) is obtained by applying the E model., Electronic Components, Technology and Materials, Microelectronics

Published
2024
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42. Positive predictive value for malignancy of uncertain malignant potential (B3) breast lesions diagnosed on vacuum-assisted biopsy (VAB): is surgical excision still recommended?

Author

Lucioni, Marco, Rossi, Chiara, Lomoro, Pascal, Ballati, Francesco, Fanizza, Marianna, Ferrari, Alberta, Garcia-Etienne, Carlos A., Boveri, Emanuela, Meloni, Giulia, Sommaruga, Maria Grazia, Ferraris, Elisa, Lasagna, Angioletta, Bonzano, Elisabetta, Paulli, Marco, Sgarella, Adele, and Di Giulio, Giuseppe

Published
2021
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43. Stimulus-related modulation in the 1/f spectral slope suggests an impaired inhibition during a working memory task in people with multiple sclerosis.

Author

Akbarian, Fahimeh, Rossi, Chiara, Costers, Lars, D'hooghe, Marie B, D'haeseleer, Miguel, Nagels, Guy, and Van Schependom, Jeroen

Subjects
*SHORT-term memory, *NEURAL transmission, *POWER spectra, *MULTIPLE sclerosis, *MAGNETOENCEPHALOGRAPHY
Abstract

Background: An imbalance of excitatory and inhibitory synaptic transmission in multiple sclerosis (MS) may lead to cognitive impairment, such as impaired working memory. The 1/f slope of electroencephalography/magnetoencephalography (EEG/MEG) power spectra is shown to be a non-invasive proxy of excitation/inhibition balance. A flatter slope is associated with higher excitation/lower inhibition. Objectives: To assess the 1/f slope modulation induced by stimulus and its association with behavioral and cognitive measures. Methods: We analyzed MEG recordings of 38 healthy controls (HCs) and 79 people with multiple sclerosis (pwMS) while performing an n-back task including target and distractor stimuli. Target trials require an answer, while distractor trials do not. We computed the 1/f spectral slope through the fitting oscillations and one over f (FOOOF) algorithm within the time windows 1 second before and after each stimulus presentation. Results: We observed a flatter 1/f slope after distractor stimuli in pwMS compared to HCs. The 1/f slope was significantly steeper after stimulus for both HCs and pwMS and was significantly correlated with reaction times. This modulation in 1/f slope was significantly correlated with visuospatial memory assessed by the BVMT-R test. Conclusion: Our results suggest possible inhibitory mechanism deficits in pwMS during a working memory task. [ABSTRACT FROM AUTHOR]

Published
2024
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44. A New and Rapid LC-MS/MS Method for the Determination of Cysteamine Plasma Levels in Cystinosis Patients.

Author

Simeoli, Raffaele, Cairoli, Sara, Greco, Marcella, Bellomo, Francesco, Mancini, Alessandro, Rossi, Chiara, Dionisi Vici, Carlo, Emma, Francesco, and Goffredo, Bianca Maria

Subjects
LIQUID chromatography-mass spectrometry, CYSTEAMINE, ORAL drug administration
Abstract

Cystinosis is a rare lysosomal storage disorder caused by autosomal recessive mutations in the CTNS gene that encodes for the cystine transporter cystinosin, which is expressed on the lysosomal membrane mediating the efflux of cystine. Cysteamine bitartrate is a cystine-depleting aminothiol agent approved for the treatment of cystinosis in children and adults. In this study, we developed and validated a liquid chromatography–tandem mass spectrometry (LC-MS/MS) method for the determination of cysteamine levels in plasma samples. This LC-MS/MS method was validated according to the European Medicines Agency (EMA)'s guidelines for bioanalytical method validation. An ultra-performance liquid chromatograph (UPLC) coupled with a 6470 mass spectrometry system was used for cysteamine determination. Our validated method was applied to plasma samples from n = 8 cystinosis patients (median, interquartile range (IQR) = 20.5, 8.5–26.0 years). The samples were collected before cysteamine oral administration (pre-dose) and 1 h after (post-dose). Our bioanalytical method fulfilled the regulatory guidelines for method validation. The cysteamine plasma levels in pre-dose samples were 2.57 and 1.50–3.31 μM (median and IQR, respectively), whereas the post-dose samples reported a cysteamine median concentration of 28.00 μM (IQR: 17.60–36.61). Our method allows the rapid determination of cysteamine plasma levels. This method was successfully used in cystinosis patients and, therefore, could be a useful tool for the evaluation of therapy adherence and for future pharmacokinetic (PK) studies involving a higher number of subjects. [ABSTRACT FROM AUTHOR]

Published
2024
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