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2. Clinical characteristics and outcomes of vaccinated patients hospitalised with SARS-CoV-2 breakthrough infection: Multi-IPV, a multicentre study in Northern Italy

Author

Bosari, Silvano, Scudeller, Luigia, Fusetti, Giuliana, Rusconi, Laura, Dell’Orto, Silvia, Prati, Daniele, Valenti, Luca, Giovannelli, Silvia, Manunta, Maria, Lamorte, Giuseppe, Ferarri, Francesca, Gori., Andrea, Bandera, Alessandra, Muscatello, Antonio, Mangioni, Davide, Alagna, Laura, Bozzi, Giorgio, Lombardi., Andrea, Ungaro, Riccardo, Ancona, Giuseppe, Mussa, Marco, Mariani, Bianca Veronica, Bolis, Matteo, Iannotti, Nathalie, Ludovisi, Serena, Comelli, Agnese, Renisi, Giulia, Biscarini, Simona, Castelli, Valeria, Palomba, Emanuele, Fava, Marco, Peri, Carlo Alberto, Saltini, Paola, Viero, Giulia, Itri, Teresa, Ferroni, Valentina, Pastore, Valeria, Massafra, Roberta, Liparoti, Arianna, Muheberimana, Toussaint, Giommi, Alessandro, Bianco, Rosaria, Chitani, Grazia Eliana, Bobbio, Chiara, De Matteis, Irene, Bonomi, Angelo Bianchi, Peyvandi, Flora, Gualtierotti, Roberta, Ferrari, Barbara, Rossio, Raffaella, Boasi, Nadia, Pagliaro, Erica, Massimo, Costanza, De Caro, Michele, Giachi, Andrea, Montano, Nicola, Vigone, Barbara, Bellocchi, Chiara, Carandina, Angelica, Fiorelli, Elisa, Melli, Valerie, Tobaldini, Eleonora, Blasi, Francesco, Aliberti, Stefano, Spotti, Maura, Terranova, Leonardo, Misuraca, Sofia, D’Adda, Alice, Della Fiore, Silvia, Di Pasquale, Marta, Mantero., Marco, Contarini, Martina, Ori, Margherita, Morlacchi, Letizia, Rossetti, Valeria, Gramegna, Andrea, Pappalettera, Maria, Cavallini, Mirta, Buscemi, Agata, Vicenzi, Marco, Rota, Irena, Costantino, Giorgio, Solbiati, Monica, Furlan, Ludovico, Mancarella, Marta, Colombo, Giulia, Colombo, Giorgio, Fanin, Alice, Passarella, Mariele, Monzani, Valter, Canetta, Ciro, Rovellini, Angelo, Barbetta, Laura, Billi, Filippo, Folli, Christian, Accordino, Silvia, Maira, Diletta, Hu, Cinzia Maria, Motta, Irene, Scaramellini, Natalia, Fracanzani, Anna Ludovica, Lombardi, Rosa, Cespiati, Annalisa, Cesari, Matteo, Lucchi, Tiziano, Proietti, Marco, Calcaterra, Laura, Mandelli, Clara, Coppola, Carlotta, Cerizza, Arturo, Pesenti, Antonio Maria, Grasselli, Giacomo, Galazzi, Alessandro, Nobili., Alessandro, Tettamanti, Mauro, Monti, Igor, Galbussera, Alessia Antonella, Crisafulli, Ernesto, Girelli, Domenico, Maroccia, Alessio, Gabbiani, Daniele, Busti, Fabiana, Vianello, Alice, Biondan, Marta, Sartori, Filippo, Faverio, Paola, Pesci, Alberto, Zucchetti, Stefano, Bonfanti, Paolo, Rossi, Marianna, Beretta, Ilaria, Spolti, Anna, Harari, Sergio, Elia, Davide, Cassandro, Roberto, Caminati, Antonella, Cipollone, Francesco, Guagnano, Maria Teresa, D’Ardes, Damiano, Rossi, Ilaria, Vezzani, Francesca, Spanevello, Antonio, Cherubino, Francesca, Visca, Dina, Contoli, Marco, Papi, Alberto, Morandi, Luca, Battistini, Nicholas, Moreo, Guido Luigi, Iannuzzi, Pasqualina, Fumagalla, Daniele, Leone, Sara, Lombardi, Andrea, Villa, Simone, Colaneri, Marta, Scaglione, Giovanni, Bai, Francesca, Varisco, Benedetta, Bono, Valeria, Vena, Antonio, Dentone, Chiara, Russo, Chiara, Azzarà, Cecilia, Mantero, Marco, Bassetti, Matteo, Marchetti, Giulia, Nobili, Alessandro, and Gori, Andrea

Published
2024
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5. The role of immune suppression in COVID-19 hospitalization: clinical and epidemiological trends over three years of SARS-CoV-2 epidemic

Author

Marta Canuti, Maria Cristina Monti, Chiara Bobbio, Antonio Muscatello, Toussaint Muheberimana, Sante Leandro Baldi, Francesco Blasi, Ciro Canetta, Giorgio Costantino, Alessandro Nobili, Flora Peyvandi, Mauro Tettamanti, Simone Villa, Stefano Aliberti, Mario C. Raviglione, Andrea Gori, Alessandra Bandera, COVID-19 Network Study Group, Bosari Silvano, Scudeller Luigia, Fusetti Giuliana, Rusconi Laura, Dell’Orto Silvia, Prati Daniele, Valenti Luca, Giovannelli Silvia, Manunta Maria, Lamorte Giuseppe, Ferarri Francesca, Mangioni Davide, Alagna Laura, Bozzi Giorgio, Lombardi Andrea, Ungaro Riccardo, Ancona Giuseppe, Zuglian Gianluca, Bolis Matteo, Iannotti Nathalie, Ludovisi Serena, Comelli Agnese, Renisi Giulia, Biscarini Simona, Castelli Valeria, Palomba Emanuele, Fava Marco, Fortina Valeria, Liparoti Arianna, Pastena Andrea, Alberto Peri Carlo, Saltini Paola, Viero Giulia, Itri Teresa, Ferroni Valentina, Pastore Valeria, Massafra Roberta, Curri Maria Teresa, Rizzo Alice, Scarpa Stefano, Giommi Alessandro, Bianco Rosaria, Chitani Grazia Eliana, Gualtierotti Roberta, Ferrari Barbara, Rossio Raffaella, Boasi Nadia, Pagliaro Erica, Massimo Costanza, Caro Michele De, Giachi Andrea, Montano Nicola, Vigone Barbara, Bellocchi Chiara, Carandina Angelica, Fiorelli Elisa, Melli Valerie, Tobaldini Eleonora, Spotti Maura, Terranova Leonardo, Misuraca Sofia, D’Adda Alice, Fiore Silvia Della, Pasquale Marta Di, Mantero Marco, Contarini Martina, Ori Margherita, Morlacchi Letizia, Rossetti Valeria, Gramegna Andrea, Pappalettera Maria, Cavallini Mirta, Buscemi Agata, Vicenzi Marco, Rota Irena, Solbiati Monica, Furlan Ludovico, Mancarella Marta, Colombo Giulia, Colombo Giorgio, Fanin Alice, Passarella Mariele, Monzani Valter, Rovellini Angelo, Barbetta Laura, Billi Filippo, Folli Christian, Accordino Silvia, Maira Diletta, Hu Cinzia Maria, Motta Irene, Scaramellini Natalia, Fracanzani Anna Ludovica, Lombardi Rosa, Cespiati Annalisa, Cesari Matteo, Lucchi Tiziano, Proietti Marco, Calcaterra Laura, Mandelli Clara, Coppola Carlotta, Cerizza Arturo, Grasselli Giacomo, Galazzi Alessandro, Monti Igor, and Galbusera Alessia Antonella

Subjects
SARS-CoV-2, COVID-19, disease outcome, hospitalization, COVID-19 vaccination, immune suppression, Medicine (General), R5-920
Abstract

Specific immune suppression types have been associated with a greater risk of severe COVID-19 disease and death. We analyzed data from patients >17 years that were hospitalized for COVID-19 at the “Fondazione IRCCS Ca′ Granda Ospedale Maggiore Policlinico” in Milan (Lombardy, Northern Italy). The study included 1727 SARS-CoV-2-positive patients (1,131 males, median age of 65 years) hospitalized between February 2020 and November 2022. Of these, 321 (18.6%, CI: 16.8–20.4%) had at least one condition defining immune suppression. Immune suppressed subjects were more likely to have other co-morbidities (80.4% vs. 69.8%, p

Published
2023
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6. Immunopathology of lung transplantation: from infection to rejection and vice versa.

Author

Righi, Ilaria, Barone, Ivan, Rosso, Lorenzo, Morlacchi, Letizia Corinna, Rossetti, Valeria, Caffarena, Giovanni, Limanaqi, Fiona, Palleschi, Alessandro, Clerici, Mario, and Trabattoni, Daria

Subjects
LUNG transplantation, TRANSPLANTATION of organs, tissues, etc., GRAFT rejection, LUNG infections, IMMUNOLOGICAL tolerance
Abstract

Lung transplantation offers a lifesaving option for patients with end-stage lung disease, but it is marred by a high risk of post-transplant infections, particularly involving multidrug-resistant bacteria, Cytomegalovirus, and fungal pathogens. This elevated infection rate, the highest among solid organ transplants, poses a significant challenge for clinicians, particularly within the first year posttransplantation, where infections are the leading cause of mortality. The direct exposure of lung allografts to the external environment exacerbates this vulnerability leading to constant immune stimulation and consequently to an elevated risk of triggering alloimmune responses to the lung allograft. The necessity of prolonged immunosuppression to prevent allograft rejection further complicates patient management by increasing susceptibility to infections and neoplasms, and complicating the differentiation between rejection and infection, which require diametrically opposed management strategies. This review explores the intricate balance between preventing allograft rejection and managing the heightened infection risk in lung transplant recipients. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Clinical characteristics and outcomes of vaccinated patients hospitalised with SARS-CoV-2 breakthrough infection: Multi-IPV, a multicentre study in Northern Italy

Author

Lombardi, Andrea, primary, Villa, Simone, additional, Colaneri, Marta, additional, Scaglione, Giovanni, additional, Bai, Francesca, additional, Varisco, Benedetta, additional, Bono, Valeria, additional, Vena, Antonio, additional, Dentone, Chiara, additional, Russo, Chiara, additional, Tettamanti, Mauro, additional, Renisi, Giulia, additional, Viero, Giulia, additional, Azzarà, Cecilia, additional, Mantero, Marco, additional, Peyvandi, Flora, additional, Bassetti, Matteo, additional, Marchetti, Giulia, additional, Muscatello, Antonio, additional, Nobili, Alessandro, additional, Gori, Andrea, additional, Bandera, Alessandra, additional, Bosari, Silvano, additional, Scudeller, Luigia, additional, Fusetti, Giuliana, additional, Rusconi, Laura, additional, Dell’Orto, Silvia, additional, Prati, Daniele, additional, Valenti, Luca, additional, Giovannelli, Silvia, additional, Manunta, Maria, additional, Lamorte, Giuseppe, additional, Ferarri, Francesca, additional, Gori., Andrea, additional, Mangioni, Davide, additional, Alagna, Laura, additional, Bozzi, Giorgio, additional, Lombardi., Andrea, additional, Ungaro, Riccardo, additional, Ancona, Giuseppe, additional, Mussa, Marco, additional, Mariani, Bianca Veronica, additional, Bolis, Matteo, additional, Iannotti, Nathalie, additional, Ludovisi, Serena, additional, Comelli, Agnese, additional, Biscarini, Simona, additional, Castelli, Valeria, additional, Palomba, Emanuele, additional, Fava, Marco, additional, Peri, Carlo Alberto, additional, Saltini, Paola, additional, Itri, Teresa, additional, Ferroni, Valentina, additional, Pastore, Valeria, additional, Massafra, Roberta, additional, Liparoti, Arianna, additional, Muheberimana, Toussaint, additional, Giommi, Alessandro, additional, Bianco, Rosaria, additional, Chitani, Grazia Eliana, additional, Bobbio, Chiara, additional, De Matteis, Irene, additional, Bonomi, Angelo Bianchi, additional, Gualtierotti, Roberta, additional, Ferrari, Barbara, additional, Rossio, Raffaella, additional, Boasi, Nadia, additional, Pagliaro, Erica, additional, Massimo, Costanza, additional, De Caro, Michele, additional, Giachi, Andrea, additional, Montano, Nicola, additional, Vigone, Barbara, additional, Bellocchi, Chiara, additional, Carandina, Angelica, additional, Fiorelli, Elisa, additional, Melli, Valerie, additional, Tobaldini, Eleonora, additional, Blasi, Francesco, additional, Aliberti, Stefano, additional, Spotti, Maura, additional, Terranova, Leonardo, additional, Misuraca, Sofia, additional, D’Adda, Alice, additional, Della Fiore, Silvia, additional, Di Pasquale, Marta, additional, Mantero., Marco, additional, Contarini, Martina, additional, Ori, Margherita, additional, Morlacchi, Letizia, additional, Rossetti, Valeria, additional, Gramegna, Andrea, additional, Pappalettera, Maria, additional, Cavallini, Mirta, additional, Buscemi, Agata, additional, Vicenzi, Marco, additional, Rota, Irena, additional, Costantino, Giorgio, additional, Solbiati, Monica, additional, Furlan, Ludovico, additional, Mancarella, Marta, additional, Colombo, Giulia, additional, Colombo, Giorgio, additional, Fanin, Alice, additional, Passarella, Mariele, additional, Monzani, Valter, additional, Canetta, Ciro, additional, Rovellini, Angelo, additional, Barbetta, Laura, additional, Billi, Filippo, additional, Folli, Christian, additional, Accordino, Silvia, additional, Maira, Diletta, additional, Hu, Cinzia Maria, additional, Motta, Irene, additional, Scaramellini, Natalia, additional, Fracanzani, Anna Ludovica, additional, Lombardi, Rosa, additional, Cespiati, Annalisa, additional, Cesari, Matteo, additional, Lucchi, Tiziano, additional, Proietti, Marco, additional, Calcaterra, Laura, additional, Mandelli, Clara, additional, Coppola, Carlotta, additional, Cerizza, Arturo, additional, Pesenti, Antonio Maria, additional, Grasselli, Giacomo, additional, Galazzi, Alessandro, additional, Nobili., Alessandro, additional, Monti, Igor, additional, Galbussera, Alessia Antonella, additional, Crisafulli, Ernesto, additional, Girelli, Domenico, additional, Maroccia, Alessio, additional, Gabbiani, Daniele, additional, Busti, Fabiana, additional, Vianello, Alice, additional, Biondan, Marta, additional, Sartori, Filippo, additional, Faverio, Paola, additional, Pesci, Alberto, additional, Zucchetti, Stefano, additional, Bonfanti, Paolo, additional, Rossi, Marianna, additional, Beretta, Ilaria, additional, Spolti, Anna, additional, Harari, Sergio, additional, Elia, Davide, additional, Cassandro, Roberto, additional, Caminati, Antonella, additional, Cipollone, Francesco, additional, Guagnano, Maria Teresa, additional, D’Ardes, Damiano, additional, Rossi, Ilaria, additional, Vezzani, Francesca, additional, Spanevello, Antonio, additional, Cherubino, Francesca, additional, Visca, Dina, additional, Contoli, Marco, additional, Papi, Alberto, additional, Morandi, Luca, additional, Battistini, Nicholas, additional, Moreo, Guido Luigi, additional, Iannuzzi, Pasqualina, additional, Fumagalla, Daniele, additional, and Leone, Sara, additional

Published
2024
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10. Clinical characteristics and outcomes of vaccinated patients hospitalised with SARS-CoV-2 breakthrough infection: Multi-IPV, a multicentre study in Northern Italy

Author

Lombardi, A, Villa, S, Colaneri, M, Scaglione, G, Bai, F, Varisco, B, Bono, V, Vena, A, Dentone, C, Russo, C, Tettamanti, M, Renisi, G, Viero, G, Azzarà, C, Mantero, M, Peyvandi, F, Bassetti, M, Marchetti, G, Muscatello, A, Nobili, A, Gori, A, Bandera, A, Bosari, S, Scudeller, L, Fusetti, G, Rusconi, L, Dell’Orto, S, Prati, D, Valenti, L, Giovannelli, S, Manunta, M, Lamorte, G, Ferarri, F, Gori., A, Mangioni, D, Alagna, L, Bozzi, G, Lombardi., A, Ungaro, R, Ancona, G, Mussa, M, Mariani, B, Bolis, M, Iannotti, N, Ludovisi, S, Comelli, A, Biscarini, S, Castelli, V, Palomba, E, Fava, M, Peri, C, Saltini, P, Itri, T, Ferroni, V, Pastore, V, Massafra, R, Liparoti, A, Muheberimana, T, Giommi, A, Bianco, R, Chitani, G, Bobbio, C, De Matteis, I, Bonomi, A, Gualtierotti, R, Ferrari, B, Rossio, R, Boasi, N, Pagliaro, E, Massimo, C, De Caro, M, Giachi, A, Montano, N, Vigone, B, Bellocchi, C, Carandina, A, Fiorelli, E, Melli, V, Tobaldini, E, Blasi, F, Aliberti, S, Spotti, M, Terranova, L, Misuraca, S, D’Adda, A, Della Fiore, S, Di Pasquale, M, Mantero., M, Contarini, M, Ori, M, Morlacchi, L, Rossetti, V, Gramegna, A, Pappalettera, M, Cavallini, M, Buscemi, A, Vicenzi, M, Rota, I, Costantino, G, Solbiati, M, Furlan, L, Mancarella, M, Colombo, G, Fanin, A, Passarella, M, Monzani, V, Canetta, C, Rovellini, A, Barbetta, L, Billi, F, Folli, C, Accordino, S, Maira, D, Hu, C, Motta, I, Scaramellini, N, Fracanzani, A, Lombardi, R, Cespiati, A, Cesari, M, Lucchi, T, Proietti, M, Calcaterra, L, Mandelli, C, Coppola, C, Cerizza, A, Pesenti, A, Grasselli, G, Galazzi, A, Nobili., A, Monti, I, Galbussera, A, Crisafulli, E, Girelli, D, Maroccia, A, Gabbiani, D, Busti, F, Vianello, A, Biondan, M, Sartori, F, Faverio, P, Pesci, A, Zucchetti, S, Bonfanti, P, Rossi, M, Beretta, I, Spolti, A, Harari, S, Elia, D, Cassandro, R, Caminati, A, Cipollone, F, Guagnano, M, D’Ardes, D, Rossi, I, Vezzani, F, Spanevello, A, Cherubino, F, Visca, D, Contoli, M, Papi, A, Morandi, L, Battistini, N, Moreo, G, Iannuzzi, P, Fumagalla, D, Leone, S, Lombardi, Andrea, Villa, Simone, Colaneri, Marta, Scaglione, Giovanni, Bai, Francesca, Varisco, Benedetta, Bono, Valeria, Vena, Antonio, Dentone, Chiara, Russo, Chiara, Tettamanti, Mauro, Renisi, Giulia, Viero, Giulia, Azzarà, Cecilia, Mantero, Marco, Peyvandi, Flora, Bassetti, Matteo, Marchetti, Giulia, Muscatello, Antonio, Nobili, Alessandro, Gori, Andrea, Bandera, Alessandra, Bosari, Silvano, Scudeller, Luigia, Fusetti, Giuliana, Rusconi, Laura, Dell’Orto, Silvia, Prati, Daniele, Valenti, Luca, Giovannelli, Silvia, Manunta, Maria, Lamorte, Giuseppe, Ferarri, Francesca, Gori. , Andrea, Mangioni, Davide, Alagna, Laura, Bozzi, Giorgio, Lombardi. , Andrea, Ungaro, Riccardo, Ancona, Giuseppe, Mussa, Marco, Mariani, Bianca Veronica, Bolis, Matteo, Iannotti, Nathalie, Ludovisi, Serena, Comelli, Agnese, Biscarini, Simona, Castelli, Valeria, Palomba, Emanuele, Fava, Marco, Peri, Carlo Alberto, Saltini, Paola, Itri, Teresa, Ferroni, Valentina, Pastore, Valeria, Massafra, Roberta, Liparoti, Arianna, Muheberimana, Toussaint, Giommi, Alessandro, Bianco, Rosaria, Chitani, Grazia Eliana, Bobbio, Chiara, De Matteis, Irene, Bonomi, Angelo Bianchi, Gualtierotti, Roberta, Ferrari, Barbara, Rossio, Raffaella, Boasi, Nadia, Pagliaro, Erica, Massimo, Costanza, De Caro, Michele, Giachi, Andrea, Montano, Nicola, Vigone, Barbara, Bellocchi, Chiara, Carandina, Angelica, Fiorelli, Elisa, Melli, Valerie, Tobaldini, Eleonora, Blasi, Francesco, Aliberti, Stefano, Spotti, Maura, Terranova, Leonardo, Misuraca, Sofia, D’Adda, Alice, Della Fiore, Silvia, Di Pasquale, Marta, Mantero. , Marco, Contarini, Martina, Ori, Margherita, Morlacchi, Letizia, Rossetti, Valeria, Gramegna, Andrea, Pappalettera, Maria, Cavallini, Mirta, Buscemi, Agata, Vicenzi, Marco, Rota, Irena, Costantino, Giorgio, Solbiati, Monica, Furlan, Ludovico, Mancarella, Marta, Colombo, Giulia, Colombo, Giorgio, Fanin, Alice, Passarella, Mariele, Monzani, Valter, Canetta, Ciro, Rovellini, Angelo, Barbetta, Laura, Billi, Filippo, Folli, Christian, Accordino, Silvia, Maira, Diletta, Hu, Cinzia Maria, Motta, Irene, Scaramellini, Natalia, Fracanzani, Anna Ludovica, Lombardi, Rosa, Cespiati, Annalisa, Cesari, Matteo, Lucchi, Tiziano, Proietti, Marco, Calcaterra, Laura, Mandelli, Clara, Coppola, Carlotta, Cerizza, Arturo, Pesenti, Antonio Maria, Grasselli, Giacomo, Galazzi, Alessandro, Nobili. , Alessandro, Monti, Igor, Galbussera, Alessia Antonella, Crisafulli, Ernesto, Girelli, Domenico, Maroccia, Alessio, Gabbiani, Daniele, Busti, Fabiana, Vianello, Alice, Biondan, Marta, Sartori, Filippo, Faverio, Paola, Pesci, Alberto, Zucchetti, Stefano, Bonfanti, Paolo, Rossi, Marianna, Beretta, Ilaria, Spolti, Anna, Harari, Sergio, Elia, Davide, Cassandro, Roberto, Caminati, Antonella, Cipollone, Francesco, Guagnano, Maria Teresa, D’Ardes, Damiano, Rossi, Ilaria, Vezzani, Francesca, Spanevello, Antonio, Cherubino, Francesca, Visca, Dina, Contoli, Marco, Papi, Alberto, Morandi, Luca, Battistini, Nicholas, Moreo, Guido Luigi, Iannuzzi, Pasqualina, Fumagalla, Daniele, Leone, Sara, Lombardi, A, Villa, S, Colaneri, M, Scaglione, G, Bai, F, Varisco, B, Bono, V, Vena, A, Dentone, C, Russo, C, Tettamanti, M, Renisi, G, Viero, G, Azzarà, C, Mantero, M, Peyvandi, F, Bassetti, M, Marchetti, G, Muscatello, A, Nobili, A, Gori, A, Bandera, A, Bosari, S, Scudeller, L, Fusetti, G, Rusconi, L, Dell’Orto, S, Prati, D, Valenti, L, Giovannelli, S, Manunta, M, Lamorte, G, Ferarri, F, Gori., A, Mangioni, D, Alagna, L, Bozzi, G, Lombardi., A, Ungaro, R, Ancona, G, Mussa, M, Mariani, B, Bolis, M, Iannotti, N, Ludovisi, S, Comelli, A, Biscarini, S, Castelli, V, Palomba, E, Fava, M, Peri, C, Saltini, P, Itri, T, Ferroni, V, Pastore, V, Massafra, R, Liparoti, A, Muheberimana, T, Giommi, A, Bianco, R, Chitani, G, Bobbio, C, De Matteis, I, Bonomi, A, Gualtierotti, R, Ferrari, B, Rossio, R, Boasi, N, Pagliaro, E, Massimo, C, De Caro, M, Giachi, A, Montano, N, Vigone, B, Bellocchi, C, Carandina, A, Fiorelli, E, Melli, V, Tobaldini, E, Blasi, F, Aliberti, S, Spotti, M, Terranova, L, Misuraca, S, D’Adda, A, Della Fiore, S, Di Pasquale, M, Mantero., M, Contarini, M, Ori, M, Morlacchi, L, Rossetti, V, Gramegna, A, Pappalettera, M, Cavallini, M, Buscemi, A, Vicenzi, M, Rota, I, Costantino, G, Solbiati, M, Furlan, L, Mancarella, M, Colombo, G, Fanin, A, Passarella, M, Monzani, V, Canetta, C, Rovellini, A, Barbetta, L, Billi, F, Folli, C, Accordino, S, Maira, D, Hu, C, Motta, I, Scaramellini, N, Fracanzani, A, Lombardi, R, Cespiati, A, Cesari, M, Lucchi, T, Proietti, M, Calcaterra, L, Mandelli, C, Coppola, C, Cerizza, A, Pesenti, A, Grasselli, G, Galazzi, A, Nobili., A, Monti, I, Galbussera, A, Crisafulli, E, Girelli, D, Maroccia, A, Gabbiani, D, Busti, F, Vianello, A, Biondan, M, Sartori, F, Faverio, P, Pesci, A, Zucchetti, S, Bonfanti, P, Rossi, M, Beretta, I, Spolti, A, Harari, S, Elia, D, Cassandro, R, Caminati, A, Cipollone, F, Guagnano, M, D’Ardes, D, Rossi, I, Vezzani, F, Spanevello, A, Cherubino, F, Visca, D, Contoli, M, Papi, A, Morandi, L, Battistini, N, Moreo, G, Iannuzzi, P, Fumagalla, D, Leone, S, Lombardi, Andrea, Villa, Simone, Colaneri, Marta, Scaglione, Giovanni, Bai, Francesca, Varisco, Benedetta, Bono, Valeria, Vena, Antonio, Dentone, Chiara, Russo, Chiara, Tettamanti, Mauro, Renisi, Giulia, Viero, Giulia, Azzarà, Cecilia, Mantero, Marco, Peyvandi, Flora, Bassetti, Matteo, Marchetti, Giulia, Muscatello, Antonio, Nobili, Alessandro, Gori, Andrea, Bandera, Alessandra, Bosari, Silvano, Scudeller, Luigia, Fusetti, Giuliana, Rusconi, Laura, Dell’Orto, Silvia, Prati, Daniele, Valenti, Luca, Giovannelli, Silvia, Manunta, Maria, Lamorte, Giuseppe, Ferarri, Francesca, Gori. , Andrea, Mangioni, Davide, Alagna, Laura, Bozzi, Giorgio, Lombardi. , Andrea, Ungaro, Riccardo, Ancona, Giuseppe, Mussa, Marco, Mariani, Bianca Veronica, Bolis, Matteo, Iannotti, Nathalie, Ludovisi, Serena, Comelli, Agnese, Biscarini, Simona, Castelli, Valeria, Palomba, Emanuele, Fava, Marco, Peri, Carlo Alberto, Saltini, Paola, Itri, Teresa, Ferroni, Valentina, Pastore, Valeria, Massafra, Roberta, Liparoti, Arianna, Muheberimana, Toussaint, Giommi, Alessandro, Bianco, Rosaria, Chitani, Grazia Eliana, Bobbio, Chiara, De Matteis, Irene, Bonomi, Angelo Bianchi, Gualtierotti, Roberta, Ferrari, Barbara, Rossio, Raffaella, Boasi, Nadia, Pagliaro, Erica, Massimo, Costanza, De Caro, Michele, Giachi, Andrea, Montano, Nicola, Vigone, Barbara, Bellocchi, Chiara, Carandina, Angelica, Fiorelli, Elisa, Melli, Valerie, Tobaldini, Eleonora, Blasi, Francesco, Aliberti, Stefano, Spotti, Maura, Terranova, Leonardo, Misuraca, Sofia, D’Adda, Alice, Della Fiore, Silvia, Di Pasquale, Marta, Mantero. , Marco, Contarini, Martina, Ori, Margherita, Morlacchi, Letizia, Rossetti, Valeria, Gramegna, Andrea, Pappalettera, Maria, Cavallini, Mirta, Buscemi, Agata, Vicenzi, Marco, Rota, Irena, Costantino, Giorgio, Solbiati, Monica, Furlan, Ludovico, Mancarella, Marta, Colombo, Giulia, Colombo, Giorgio, Fanin, Alice, Passarella, Mariele, Monzani, Valter, Canetta, Ciro, Rovellini, Angelo, Barbetta, Laura, Billi, Filippo, Folli, Christian, Accordino, Silvia, Maira, Diletta, Hu, Cinzia Maria, Motta, Irene, Scaramellini, Natalia, Fracanzani, Anna Ludovica, Lombardi, Rosa, Cespiati, Annalisa, Cesari, Matteo, Lucchi, Tiziano, Proietti, Marco, Calcaterra, Laura, Mandelli, Clara, Coppola, Carlotta, Cerizza, Arturo, Pesenti, Antonio Maria, Grasselli, Giacomo, Galazzi, Alessandro, Nobili. , Alessandro, Monti, Igor, Galbussera, Alessia Antonella, Crisafulli, Ernesto, Girelli, Domenico, Maroccia, Alessio, Gabbiani, Daniele, Busti, Fabiana, Vianello, Alice, Biondan, Marta, Sartori, Filippo, Faverio, Paola, Pesci, Alberto, Zucchetti, Stefano, Bonfanti, Paolo, Rossi, Marianna, Beretta, Ilaria, Spolti, Anna, Harari, Sergio, Elia, Davide, Cassandro, Roberto, Caminati, Antonella, Cipollone, Francesco, Guagnano, Maria Teresa, D’Ardes, Damiano, Rossi, Ilaria, Vezzani, Francesca, Spanevello, Antonio, Cherubino, Francesca, Visca, Dina, Contoli, Marco, Papi, Alberto, Morandi, Luca, Battistini, Nicholas, Moreo, Guido Luigi, Iannuzzi, Pasqualina, Fumagalla, Daniele, and Leone, Sara

Abstract

Background: Despite the well-known efficacy of anti-COVID-19 vaccines in preventing morbidity and mortality, several vaccinated individuals are diagnosed with SARS-CoV-2 breakthrough infection, which might require hospitalisation. This multicentre, observational, and retrospective study aimed to investigate the clinical characteristics and outcomes of vaccinated vs. non-vaccinated patients, both hospitalised with SARS-CoV-2 infection in 3 major hospitals in Northern Italy. Methods: Data collection was retrospective, and paper and electronic medical records of adult patients with a diagnosed SARS-CoV-2 infection were pseudo-anonymised and analysed. Vaccinated and non-vaccinated individuals were manually paired, using a predetermined matching criterion (similar age, gender, and date of hospitalisation). Demographic, clinical, treatment, and outcome data were compared between groups differing by vaccination status using Pearson's Chi-square and Mann-Whitney tests. Moreover, multiple logistic regression analyses were performed to assess the impact of vaccination status on ICU admission or intra-hospital mortality. Results: Data from 360 patients were collected. Vaccinated patients presented with a higher prevalence of relevant comorbidities, like kidney replacement therapy or haematological malignancy, despite a milder clinical presentation at the first evaluation. Non-vaccinated patients required intensive care more often than their vaccinated counterparts (8.8% vs. 1.7%, p = 0.002). Contrariwise, no difference in intra-hospital mortality was observed between the two groups (19% vs. 20%, p = 0.853). These results were confirmed by multivariable logistic regressions, which showed that vaccination was significantly associated with decreased risk of ICU admission (aOR=0.172, 95%CI: 0.039–0.542, p = 0.007), but not of intra-hospital mortality (aOR=0.996, 95%CI: 0.582–1.703, p = 0.987). Conclusions: This study provides real-world data on vaccinated patients hospitalised wit

Published
2024

11. COVID-19 Vaccine in Lung and Liver Transplant Recipients Exceeds Expectations: An Italian Real-Life Experience on Immunogenicity and Clinical Efficacy of BNT162b2 Vaccine.

Author

Morlacchi, Letizia Corinna, Alicandro, Gianfranco, Renteria, Sara Uceda, Zignani, Nunzio, Giacomel, Giovanni, Rossetti, Valeria, Sagasta, Michele, Citterio, Gaia, Lombardi, Andrea, Dibenedetto, Clara, Antonelli, Barbara, Rosso, Lorenzo, Lampertico, Pietro, Ceriotti, Ferruccio, Blasi, Francesco, and Donato, Maria Francesca

Subjects
LUNG transplantation, LIVER transplantation, VACCINE effectiveness, IMMUNE response, COVID-19 vaccines
Abstract

This study assessed humoral and T cell-mediated immune responses to the BNT162b2 vaccine in orthotopic liver transplant (OLT) and lung transplant (LUT) recipients who received three doses of the vaccine from March 2021 at our institution. Serum samples were collected 60 days post-second and third dose to quantify antibodies against the spike region of SARS-CoV-2 while whole blood samples were collected to analyze the SARS-CoV-2-specific T-cell response using an IFN-γ ELISpot assay. We enrolled 244 OLT and 120 LUT recipients. The third dose increased antibody titres in OLT recipients (from a median value of 131 after the second dose to 5523 IU/mL, p < 0.001) and LUT recipients (from 14.8 to 1729 IU/mL, p < 0.001). T-cell response also increased in OLT recipients (from 8.5 to 23 IFN-γ SFU per 250,000 PBMC, p < 0.001) and LUT recipients (from 8 to 15 IFN-γ SFU per 250,000 PBMC, p < 0.001). A total of 128 breakthrough infections were observed: two (0.8%) OLT recipients were hospitalized due to COVID-19 and one died (0.4%); among LUT recipients, seven were hospitalized (5.8%) and two patients died (1.7%). In conclusion, the three-dose schedule of the BNT162b2 vaccine elicited both humoral and T cell-mediated responses in solid organ transplant recipients. The risk of severe COVID-19 post-vaccination was low in this population. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Petrous Bone Cholesteatoma: Facial and Hearing Preservation.

Author

Pace, Annalisa, Visconti, Irene Claudia, Iannella, Giannicola, Milani, Alessandro, Rossetti, Valeria, Cocuzza, Salvatore, Maniaci, Antonino, Messineo, Daniela, and Magliulo, Giuseppe

Subjects
DEAFNESS prevention, VESTIBULAR apparatus, BONE conduction, CHOLESTEATOMA, ENDOSCOPIC surgery, RETROSPECTIVE studies, DESCRIPTIVE statistics, AUDIOMETRY, SPIRAL computed tomography, MAGNETIC resonance imaging, PETROUS bone, SURGICAL complications, PRE-tests & post-tests, FACIAL nerve, HEARING, ENDOSCOPY
Abstract

Objectives : Petrous bone cholesteatoma (PBC) is a rare condition of the petrous portion of the temporal bone. Treatment of choice consists of radical surgical removal, paying attention to protect the facial nerve and inner ear as far as possible. The aim of the present study was to evaluate the efficacy of modified translabyrinthine techniques in preserving hearing function and the use of the adjuvant endoscopic techniques in a group of PBC patients. Methods : This study comprised 16 cases of PBCs surgically treated in our Department. Pre- and post-operative hearing status was assessed with pure tone audiometry and speech discrimination and graded according to the Gardner- Robertson classification system. Facial function was based on the House Brackman (HB) classification. PBCs were grouped using Sanna's classification. The choice of surgical technique was based on the above findings together with preoperative evidence. Post-operative follow-up ranged from 1 to 10 years and also included Computed Tomography and Magnetic Resonance Imaging assessment. Results : PBCs were classified as follows: 37.5% infralabyrinthine; 43.75% supralabyrinthine; and 18.75% massive. Preservation of the bone conduction threshold was feasible in 62.5% of patients. For supralabyrinthine PBCs a subtotal petrosetomy was performed in all cases and hearing preservation was possible in 57% of them: an adjuvant endoscopic approach was performed in 43%. Infralabyrinthine PBCs were treated using a modified translabyrinthine approach with preservation of bone conduction in 83% of patients; an adjuvant endoscopic approach was performed in 50% cases. One patient with a massive cholesteatoma was treated by modified translabyrinthine approach, preserving a serviceable level of hearing. In all massive cases, an adjuvant endoscopic approach was performed. In 2 patients with preoperative palsy, facial nerve function showed an improvement. The follow-up period revealed evidence of limited recurrence at CT imaging in 2 patients. Conclusions : The introduction of modified surgical approaches, able to preserve the anatomical-functional structures, have shown an improvement of post-operative hearing outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Hemodynamic failure and graft dysfunction after lung transplant: A possible clinical continuum with immediate and long‐term consequences

Author

Scaravilli, Vittorio, primary, Guzzardella, Amedeo, additional, Madotto, Fabiana, additional, Morlacchi, Letizia Corinna, additional, Bosone, Marco, additional, Bonetti, Claudia, additional, Musso, Valeria, additional, Rossetti, Valeria, additional, Russo, Filippo Maria, additional, Sorbo, Lorenzo Del, additional, Blasi, Francesco, additional, Nosotti, Mario, additional, Zanella, Alberto, additional, and Grasselli, Giacomo, additional

Published
2023
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16. Late Breaking Abstract - Speckle-tracking right ventricle free wall longitudinal strain: a new non-invasive highly sensitive tool for screening right ventricle function of lung transplant candidates

Author

Scaravilli, Vittorio, primary, Meani, Paolo, additional, Scansani, Silvia, additional, Morlacchi, Letizia, additional, Rossetti, Valeria, additional, Vicenzi, Marco, additional, Turconi, Gloria, additional, Musso, Valeria, additional, Guzzardella, Amedeo, additional, Nosotti, Mario, additional, Blasi, Francesco, additional, and Grasselli, Giacomo, additional

Published
2023
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17. Isolated Congenital Mastoid Cholesteatoma with no Involvement of Aditus Ad Antrum and Middle Ear

Author

Pace Annalisa, Iannella Giannicola, Rossetti Valeria, Messineo Daniela, Visconti Irene Claudia, Polimeni Roberta, Milani Alessandro, and Magliulo Giuseppe

Subjects
Medicine (General), R5-920
Abstract

Cholesteatoma is a non-neoplastic, keratinized squamous epithelial lesion that affects the temporal bone. The middle ear is the most frequent, while the isolated cholesteatoma of the mastoid is rare. The aim of this study was to describe a rare case of isolated mastoid cholesteatoma with no involvement of aditus ad antrum and middle ear including a literature review of the topic. This case report describes the case of a 58 years old female with a cholesteatoma isolated in the mastoid region, evidenced by imaging (computer tomography and magnetic resonance). A mastoidectomy was performed: mastoid process was completely involved, but antrum was not reached. Moreover, it reached the soft tissue of stylomastoid foramen as well as the posterior belly of the digastric muscle. In the literature few articles described cases of cholesteatoma isolated in the mastoid region. Research was conducted using PubMed and reference list and there were considered only reports about cholesteatoma exclusively located in the mastoid process without involvement of antrum or middle ear. Fourteen articles were included in this review, with a total number of 23 cases of cholesteatoma isolated in the mastoid region. All papers analyzed reported the cases of isolated mastoid cholesteatoma that presented a congenital origin. Its diagnosis is difficult, therefore, imaging evaluation is mandatory and surgery is the treatment of choice. Mastoid cholesteatomas without involvement of aditus ad antrum and middle ear are rare and only 23 cases are reported in literature. Our case is in line with all clinical and diagnostic features of this rare disease, but it is the only one that evidenced an exposure of the soft tissue of stylomastoid foramen as well as the posterior belly of the digastric muscle. The treatment of choice was the surgical one, avoiding damaging of important anatomo-functional structure.

Published
2021
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18. Immune profile changes induced by extracorporeal photopheresis as prophylactic therapy in lung transplanted cystic fibrosis patients

Author

Fenizia, Claudio, primary, Righi, Ilaria, additional, Vanetti, Claudia, additional, Biasin, Mara, additional, Rosso, Lorenzo, additional, Torretta, Lorella, additional, Mocellin, Maria Cristina, additional, Morlacchi, Letizia, additional, Rossetti, Valeria, additional, Diotti, Cristina, additional, Nosotti, Mario, additional, Clerici, Mario, additional, and Trabattoni, Daria, additional

Published
2023
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19. Lung Transplantation From Controlled and Uncontrolled Donation After Circulatory Death (DCD) Donors With Long Ischemic Times Managed by Simple Normothermic Ventilation and Ex-Vivo Lung Perfusion Assessment

Author

Palleschi, A, Zanella, A, Citerio, G, Musso, V, Rosso, L, Tosi, D, Fumagalli, J, Bonitta, G, Benazzi, E, Lopez, G, Rossetti, V, Morlacchi, L, Uslenghi, C, Cardillo, M, Blasi, F, Grasselli, G, Valenza, F, Nosotti, M, Palleschi, Alessandro, Zanella, Alberto, Citerio, Giuseppe, Musso, Valeria, Rosso, Lorenzo, Tosi, Davide, Fumagalli, Jacopo, Bonitta, Gianluca, Benazzi, Elena, Lopez, Gianluca, Rossetti, Valeria, Morlacchi, Letizia Corinna, Uslenghi, Clarissa, Cardillo, Massimo, Blasi, Francesco, Grasselli, Giacomo, Valenza, Franco, Nosotti, Mario, Palleschi, A, Zanella, A, Citerio, G, Musso, V, Rosso, L, Tosi, D, Fumagalli, J, Bonitta, G, Benazzi, E, Lopez, G, Rossetti, V, Morlacchi, L, Uslenghi, C, Cardillo, M, Blasi, F, Grasselli, G, Valenza, F, Nosotti, M, Palleschi, Alessandro, Zanella, Alberto, Citerio, Giuseppe, Musso, Valeria, Rosso, Lorenzo, Tosi, Davide, Fumagalli, Jacopo, Bonitta, Gianluca, Benazzi, Elena, Lopez, Gianluca, Rossetti, Valeria, Morlacchi, Letizia Corinna, Uslenghi, Clarissa, Cardillo, Massimo, Blasi, Francesco, Grasselli, Giacomo, Valenza, Franco, and Nosotti, Mario

Abstract

Donation after cardiac death (DCD) donors are still subject of studies. In this prospective cohort trial, we compared outcomes after lung transplantation (LT) of subjects receiving lungs from DCD donors with those of subjects receiving lungs from donation after brain death (DBD) donors (ClinicalTrial.gov: NCT02061462). Lungs from DCD donors were preserved in-vivo through normothermic ventilation, as per our protocol. We enrolled candidates for bilateral LT ≥14 years. Candidates for multi-organ or re-LT, donors aged ≥65 years, DCD category I or IV donors were excluded. We recorded clinical data on donors and recipients. Primary endpoint was 30-day mortality. Secondary endpoints were: duration of mechanical ventilation (MV), intensive care unit (ICU) length of stay, severe primary graft dysfunction (PGD3) and chronic lung allograft dysfunction (CLAD). 121 patients (110 DBD Group, 11 DCD Group) were enrolled. 30-day mortality and CLAD prevalence were nil in the DCD Group. DCD Group patients required longer MV (DCD Group: 2 days, DBD Group: 1 day, p = 0.011). ICU length of stay and PGD3 rate were higher in DCD Group but did not significantly differ. LT with DCD grafts procured with our protocols appears safe, despite prolonged ischemia times.

Published
2023

20. Lung Transplantation From Controlled and Uncontrolled Donation After Circulatory Death (DCD) Donors With Long Ischemic Times Managed by Simple Normothermic Ventilation and Ex-Vivo Lung Perfusion Assessment

Author

Palleschi, Alessandro, primary, Zanella, Alberto, additional, Citerio, Giuseppe, additional, Musso, Valeria, additional, Rosso, Lorenzo, additional, Tosi, Davide, additional, Fumagalli, Jacopo, additional, Bonitta, Gianluca, additional, Benazzi, Elena, additional, Lopez, Gianluca, additional, Rossetti, Valeria, additional, Morlacchi, Letizia Corinna, additional, Uslenghi, Clarissa, additional, Cardillo, Massimo, additional, Blasi, Francesco, additional, Grasselli, Giacomo, additional, Valenza, Franco, additional, and Nosotti, Mario, additional

Published
2023
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26. Lung transplantation for interstitial lung disease in idiopathic inflammatory myositis: A cohort study

Author

Rivière, Amélie, primary, Picard, Clément, additional, Berastegui, Cristina, additional, Mora, Victor Manuel, additional, Bunel, Vincent, additional, Godinas, Laurent, additional, Salvaterra, Elena, additional, Rossetti, Valeria, additional, Savale, Laurent, additional, Israel-Biet, Dominique, additional, Demant, Xavier, additional, Bermudez, Julien, additional, Meloni, Federica, additional, Jaksch, Peter, additional, Magnusson, Jesper, additional, Beaumont, Laurence, additional, Perch, Michael, additional, Mornex, Jean-François, additional, Knoop, Christiane, additional, Aubert, John-David, additional, Hervier, Baptiste, additional, Nunes, Hilario, additional, Humbert, Marc, additional, Gottlieb, Jens, additional, Uzunhan, Yurdagul, additional, and Le Pavec, Jérôme, additional

Published
2022
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29. Lung transplantation for interstitial lung disease in idiopathic inflammatory myositis:A cohort study

Author

Rivière, Amélie, Picard, Clément, Berastegui, Cristina, Mora, Victor Manuel, Bunel, Vincent, Godinas, Laurent, Salvaterra, Elena, Rossetti, Valeria, Savale, Laurent, Israel-Biet, Dominique, Demant, Xavier, Bermudez, Julien, Meloni, Federica, Jaksch, Peter, Magnusson, Jesper, Beaumont, Laurence, Perch, Michael, Mornex, Jean François, Knoop, Christiane, Aubert, John David, Hervier, Baptiste, Nunes, Hilario, Humbert, Marc, Gottlieb, Jens, Uzunhan, Yurdagul, Le Pavec, Jérôme, Rivière, Amélie, Picard, Clément, Berastegui, Cristina, Mora, Victor Manuel, Bunel, Vincent, Godinas, Laurent, Salvaterra, Elena, Rossetti, Valeria, Savale, Laurent, Israel-Biet, Dominique, Demant, Xavier, Bermudez, Julien, Meloni, Federica, Jaksch, Peter, Magnusson, Jesper, Beaumont, Laurence, Perch, Michael, Mornex, Jean François, Knoop, Christiane, Aubert, John David, Hervier, Baptiste, Nunes, Hilario, Humbert, Marc, Gottlieb, Jens, Uzunhan, Yurdagul, and Le Pavec, Jérôme

Abstract

In patients with interstitial lung disease (ILD) complicating classical or amyopathic idiopathic inflammatory myopathy (IIM), lung transplantation outcomes might be affected by the disease and treatments. Here, our objective was to assess survival and prognostic factors in lung transplant recipients with IIM-ILD. We retrospectively reviewed data for 64 patients who underwent lung transplantation between 2009 and 2021 at 19 European centers. Patient survival was the primary outcome. At transplantation, the median age was 53 [46–59] years, 35 (55%) patients were male, 31 (48%) had classical IIM, 25 (39%) had rapidly progressive ILD, and 21 (33%) were in a high-priority transplant allocation program. Survival rates after 1, 3, and 5 years were 78%, 73%, and 70%, respectively. During follow-up (median, 33 [7–63] months), 23% of patients developed chronic lung allograft dysfunction. Compared to amyopathic IIM, classical IIM was characterized by longer disease duration, higher-intensity immunosuppression before transplantation, and significantly worse posttransplantation survival. Five (8%) patients had a clinical IIM relapse, with mild manifestations. No patient experienced ILD recurrence in the allograft. Posttransplantation survival in IIM-ILD was similar to that in international all-cause-transplantation registries. The main factor associated with worse survival was a history of muscle involvement (classical IIM). In lung transplant recipients with idiopathic inflammatory myopathy, survival was similar to that in all-cause transplantation and was worse in patients with muscle involvement compared to those with the amyopathic disease.

Published
2022

30. Evaluation of Vestibular Function in Patients Affected by Obstructive Sleep Apnea Performing Functional Head Impulse Test (fHIT)

Author

Pace,Annalisa, Milani,Alessandro, Rossetti,Valeria, Iannella,Giannicola, Maniaci,Antonino, Cocuzza,Salvatore, Alunni Fegatelli,Danilo, Vestri,Annarita, Magliulo,Giuseppe, Pace,Annalisa, Milani,Alessandro, Rossetti,Valeria, Iannella,Giannicola, Maniaci,Antonino, Cocuzza,Salvatore, Alunni Fegatelli,Danilo, Vestri,Annarita, and Magliulo,Giuseppe

Abstract

Annalisa Pace,1,2 Alessandro Milani,1 Valeria Rossetti,1 Giannicola Iannella,1– 3 Antonino Maniaci,4 Salvatore Cocuzza,4 Danilo Alunni Fegatelli,5 Annarita Vestri,5 Giuseppe Magliulo1 1Organi di Senso Department, Sapienza University, Rome, Italy; 2Scienze Chirurgiche Department, Sapienza University, Rome, Italy; 3Department of Head-Neck Surgery, Morgagni Pierantoni Hospital, Forlì, Italy; 4Otorinolaringoiatria Department, University of Catania, Catania, Italy; 5Department of Public Health and Infectious Diseases, Sapienza University, Rome, ItalyCorrespondence: Annalisa Pace, Organi di Senso Department, Sapienza University, Viale dell’Università 33 Rome, 00165, Italy, Tel +393203581431, Fax +390649976817, Email annalisapace90@gmail.comPurpose: Obstructive sleep apnoea (OSA) is a common disease with significantly related complications. Since a connection between the vestibular nucleus and sleep regulator pathways has been demonstrated, vestibular evaluation in OSA patients was partially studied and none used functional head impulse test (fHIT) for this purpose. This paper aimed at evaluating the vestibular function in patients affected by OSA using fHIT, selecting patients who did not present any other related to cardiovascular, neurological, or metabolic diseases.Patients and Methods: Patients enrolled had a diagnosis of OSA by polysomnography type III and were cataloged according to American Association of Sleep Medicine criteria. Each patient underwent fHIT. Statistical significance was set at 0.05.Results: A total of 85 patients were enrolled in the study of which 50 had a diagnosis of OSA and were included in the case group, while 35 belonged to the control group. In 88.6% of subjects of the case group was evidenced a vestibular impairment with a substantial difference between the two study groups (p< 0.05).Conclusion: The results show that the incidence of vestibular lesions in patients with obstructive sleep apnoea is underestimated and that fHIT can i

Published
2022

31. Lung transplantation for interstitial lung disease in idiopathic inflammatory myositis: A cohort study

Author

Rivière, Amélie, Picard, Clément, Berastegui, Cristina, Mora, Victor Manuel, Bunel, Vincent, Godinas, Laurent, Salvaterra, Elena, Rossetti, Valeria, Savale, Laurent, Israël-Biet, Dominique, Demant, Xavier, Bermudez, Julien, Meloni, Federica, Jaksch, Peter, Magnusson, Jesper, Beaumont, Laurence, Perch, Michael, Mornex, Jean-François, Knoop, Christiane, Aubert, John D., Hervier, Baptiste, Nunes, Hilario, Humbert, Marc, Gottlieb, Jens, Uzunhan, Yurdagul, Le Pavec, Jérôme, Rivière, Amélie, Picard, Clément, Berastegui, Cristina, Mora, Victor Manuel, Bunel, Vincent, Godinas, Laurent, Salvaterra, Elena, Rossetti, Valeria, Savale, Laurent, Israël-Biet, Dominique, Demant, Xavier, Bermudez, Julien, Meloni, Federica, Jaksch, Peter, Magnusson, Jesper, Beaumont, Laurence, Perch, Michael, Mornex, Jean-François, Knoop, Christiane, Aubert, John D., Hervier, Baptiste, Nunes, Hilario, Humbert, Marc, Gottlieb, Jens, Uzunhan, Yurdagul, and Le Pavec, Jérôme

Abstract

In patients with interstitial lung disease (ILD) complicating classical or amyopathic idiopathic inflammatory myopathy (IIM), lung transplantation outcomes might be affected by the disease and treatments. Here, our objective was to assess survival and prognostic factors in lung transplant recipients with IIM-ILD. We retrospectively reviewed data for 64 patients who underwent lung transplantation between 2009 and 2021 at 19 European centers. Patient survival was the primary outcome. At transplantation, the median age was 53 [46–59] years, 35 (55%) patients were male, 31 (48%) had classical IIM, 25 (39%) had rapidly progressive ILD, and 21 (33%) were in a high-priority transplant allocation program. Survival rates after 1, 3, and 5 years were 78%, 73%, and 70%, respectively. During follow-up (median, 33 [7–63] months), 23% of patients developed chronic lung allograft dysfunction. Compared to amyopathic IIM, classical IIM was characterized by longer disease duration, higher-intensity immunosuppression before transplantation, and significantly worse posttransplantation survival. Five (8%) patients had a clinical IIM relapse, with mild manifestations. No patient experienced ILD recurrence in the allograft. Posttransplantation survival in IIM-ILD was similar to that in international all-cause-transplantation registries. The main factor associated with worse survival was a history of muscle involvement (classical IIM). In lung transplant recipients with idiopathic inflammatory myopathy, survival was similar to that in all-cause transplantation and was worse in patients with muscle involvement compared to those with the amyopathic disease., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2022

32. Bone Disease in Long-Term Lung Transplant Survivors.

Author

Grassi, Giorgia, Cairoli, Elisa, Gentile, Lucrezia Maria Silvana, Chiodini, Iacopo, Zampogna, Marta, Ghielmetti, Alberto, Morlacchi, Letizia Corinna, Rossetti, Valeria, Rosso, Lorenzo, Righi, Ilaria, Nosotti, Mario, Arosio, Maura, Blasi, Francesco, and Eller Vainicher, Cristina

Subjects
FEMUR neck, LUMBAR vertebrae, BONE diseases, LUNG transplantation, BONE density, CANCELLOUS bone, LUNG diseases
Abstract

Background: During the first two years after lung transplantation (LTx), the incidence of fragility fractures (FX) is estimated to be 15–50% and it is lower in patients with cystic fibrosis (CF) as compared with other end-stage lung diseases (nCF). The aim of our study is to compare the skeletal outcomes, after the first 2 years post-LTx, in long-term survivors with CF and nCF. Materials and Methods: We evaluated the FX rate, the changes in bone mineral density (BMD) and trabecular bone score (TBS) in 68 patients (38 CF and 30 nCF) who underwent LTx in our center and with a follow-up after LTx longer than 5 years (7.3 ± 2.0 years). Results: After the second year post-LTx: (i) the FX rate was lower than during the first two years post-LTx (4.4 vs. 20.6%, p = 0.004), with no difference between CF and nCF patients (5.3 vs. 3.3%, p = 0.589); (ii) BMD at lumbar spine, femoral neck and total hip remained stable (−1.6 ± 1.0 vs. −1.4 ± 1.1, p = 0.431, −1.8 ± 0.9 vs. −1.9 ± 0.9, p = 0.683, −1.5 ± 0.9 vs. −1.4 ± 0.9, p = 0.678, respectively) as well as TBS (1.200 ± 0.124 vs. 1.199 ± 0.205, p = 0.166). Conclusions: After the second year post-LTx, the skeletal complications become less frequent and have similar incidence in patients with CF and nCF. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Thiersch graft follow-up with narrow band imaging for Acquired atresia of the external auditory canal: Canaloplasty with thiersch graft vs vascularization evaluated with narrow band imaging

Author

Pace, Annalisa, primary, Rossetti, Valeria, additional, Visconti, Irene Claudia, additional, Milani, Alessandro, additional, Iannella, Giannicola, additional, Maniaci, Antonino, additional, Cocuzza, Salvatore, additional, and Magliulo, Giuseppe, additional

Published
2022
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37. Obstructive sleep apnoea patients vs laryngopharyngeal reflux disease: Non-invasive evaluation with NBI and pepsin detection in tears

Author

Pace, Annalisa, Rossetti, Valeria, Milani, Alessandro, Iannella, Giannicola, Salvatore, Cocuzza, Antonino, Maniaci, ALUNNI FEGATELLI, Danilo, Vestri, Anna Rita, Greco, Antonio, DE VINCENTIIS, Marco, Giovannetti, Francesca, Plateroti, Rocco, and Magliulo, Giuseppe

Subjects
laryngopharyngeal reflux disease, narrowband imaging, obstructive sleep apnea, pepsin, Narrow Band Imaging, Sleep Apnea, Obstructive, Tears, Laryngopharyngeal Reflux, Quality of Life, Humans, Pepsin A
Abstract

Obstructive sleep apnoea (OSA) and laryngopharyngeal reflux disease (LPR) are two common diseases that lower patients' quality of life. OSA is defined by cyclic events of airflow obstruction that occur during sleep, while LPR is characterized by upper airway inflammatory signs and symptoms due to the return of gastroduodenal gaseous and liquid elements. pH-metry is the gold standard in LPR diagnosis, but considering its invasiveness among other negative traits, questionnaires that catalog symptoms and signs of the disease such as Reflux Symptoms Index (RSI) and Reflux Finding Score (RFS) are preferred. Moreover, LPR can be evaluated by testing the presence of pepsin in tears, and Narrow Band Imaging (NBI) has been introduced for the early diagnosis of larynx oncological disease. This paper aims to test whether LPR is more frequent in OSA patients than in control ones, performing a non-invasive protocol composed of RSI, RFS test (with light vs. NBI techniques), followed by pepsin detection in tears. 68 LPR patients were enrolled in the study (45 with OSA and 23 without OSA). A strong linear relationship between Apnea-Hypopnea Index (AHI) and Oxygen Desaturation Index (ODI) was found, and patients who presented pepsin in tears had higher values of AHI and ODI in comparison to patients without it. Pathological RFS and NBI showed higher values of AHI and ODI in comparison to the control group. Furthermore, pathological RSI showed higher values of AHI and ODI in comparison to the control group. In conclusion, this diagnostic combined non-invasive protocol may be a good method to perform an early diagnosis of LPR.

Published
2022

39. Osa patients vs laryngopharyngeal reflux disease: Non-invasive evaluation with NBI and pepsin detection in tears

Author

Pace, Annalisa, primary, Rossetti, Valeria, additional, Milani, Alessandro, additional, Iannella, Giannicola, additional, Cocuzza, Salvatore, additional, Maniaci, Antonino, additional, Fegatelli, Danilo Alunni, additional, Vestri, Annarita, additional, Greco, Antonio, additional, De Vincentiis, Marco, additional, Giovannetti, Francesca, additional, Plateroti, Rocco, additional, and Magliulo, Giuseppe, additional

Published
2022
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40. 455 Haemodynamic prediction of primary graft dysfunction in lung transplant recipients

Author

Valcher, Stefano, primary, Blasi, Federico, additional, Rota, Irene, additional, Morlacchi, Letizia Corinna, additional, Rossetti, Valeria, additional, Nosotti, Mario, additional, Rosso, Lorenzo, additional, Mendogni, Paolo, additional, Grasselli, Giacomo, additional, Scaravilli, Vittorio, additional, Carugo, Stefano, additional, and Vicenzi, Marco, additional

Published
2021
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42. Petrous Bone Cholesteatoma: Facial and Hearing Preservation

Author

Pace, Annalisa, primary, Visconti, Irene Claudia, additional, Iannella, Giannicola, additional, Milani, Alessandro, additional, Rossetti, Valeria, additional, Cocuzza, Salvatore, additional, Maniaci, Antonino, additional, Messineo, Daniela, additional, and Magliulo, Giuseppe, additional

Published
2021
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43. Immune Checkpoints Expression in Chronic Lung Allograft Rejection

Author

Righi, Ilaria, primary, Vaira, Valentina, additional, Morlacchi, Letizia Corinna, additional, Croci, Giorgio Alberto, additional, Rossetti, Valeria, additional, Blasi, Francesco, additional, Ferrero, Stefano, additional, Nosotti, Mario, additional, Rosso, Lorenzo, additional, and Clerici, Mario, additional

Published
2021
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44. Audiological and vestibular evaluations in vitiligo patients

Author

Manno, Alessandra, primary, Pace, Annalisa, additional, Iannella, Giannicola, additional, Rossetti, Valeria, additional, Polimeni, Roberta, additional, Milani, Alessandro, additional, Cocuzza, Salvatore, additional, Maniaci, Antonino, additional, and Magliulo, Giuseppe, additional

Published
2021
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46. Overcoming the Limits of Reconditioning - Seventeen Hours of Ex-Vivo Lung Perfusion (EVLP) with Successful Transplantation from Uncontrolled Circulatory Death Donor

Author

Palleschi, Alessandro, Rosso, Lorenzo, Ruggeri, Giulia Maria, Croci, Giorgio Alberto, Rossetti, Valeria, Citerio, Giuseppe, Grasselli, Giacomo, Nosotti, Mario, Zanella, Alberto, Palleschi, A, Rosso, L, Ruggeri, G, Croci, G, Rossetti, V, Citerio, G, Grasselli, G, Nosotti, M, and Zanella, A

Subjects
Ex-Vivo Lung Perfusion (EVLP), lung transplantation, Uncontrolled donors after circulatory death (DCD)
Abstract

Background: Uncontrolled donors after circulatory death (DCD) are an extraordinary resource to increase the number of lungs available for transplantation. However, the risk of the warm ischemia resulting from cardiac arrest to irreversibly damage the organs is considerable. Moreover, graft preservation issues and organizational problems often worsen the dangerous effects of warm ischemia. Ex-Vivo Lung Perfusion (EVLP) enables to evaluate and recondition lungs whose functionality is doubtful, as well as to overcome the difficulties related to time and logistics. Methods: We report the case of uncontrolled DCD lungs successfully treated with an exceptionally prolonged EVLP. Since the donor’s blood count and liver biopsy showed signs of a possible leukaemia, EVLP was protracted up to seventeen hours while waiting for immunohistochemical analyses to rule out this diagnosis; eventually, the results came back negative and lungs were judged suitable for transplantation. Results: The recipient was a 32-year old male with cystic fibrosis, colonized by Pandoraea pnomenusa. Bilateral transplantation required central extracorporeal membrane oxygenation. The patient was extubated after 36 hours and was discharged 21 days after the operation. Despite early recolonization by Pandoraea pnomenusa and airway complications requiring pneumatic dilatation, he is alive and has a satisfactory respiratory function 15 months after transplantation. Conclusions: Uncontrolled DCD represents a challenge due to both logistical issues and the complexity of grafts evaluation before procurement: EVLP with cellular perfusate could be a valuable tool to overcome these limits. Nonetheless, caution should be exercised when interpreting the effects of this technique on airway healing.

Published
2021

47. Overcoming the Limits of Reconditioning - Seventeen Hours of Ex-Vivo Lung Perfusion (EVLP) with Successful Transplantation from Uncontrolled Circulatory Death Donor

Author

Palleschi, A, Rosso, L, Ruggeri, G, Croci, G, Rossetti, V, Citerio, G, Grasselli, G, Nosotti, M, Zanella, A, Palleschi, Alessandro, Rosso, Lorenzo, Ruggeri, Giulia Maria, Croci, Giorgio Alberto, Rossetti, Valeria, Citerio, Giuseppe, Grasselli, Giacomo, Nosotti, Mario, Zanella, Alberto, Palleschi, A, Rosso, L, Ruggeri, G, Croci, G, Rossetti, V, Citerio, G, Grasselli, G, Nosotti, M, Zanella, A, Palleschi, Alessandro, Rosso, Lorenzo, Ruggeri, Giulia Maria, Croci, Giorgio Alberto, Rossetti, Valeria, Citerio, Giuseppe, Grasselli, Giacomo, Nosotti, Mario, and Zanella, Alberto

Abstract

Background: Uncontrolled donors after circulatory death (DCD) are an extraordinary resource to increase the number of lungs available for transplantation. However, the risk of the warm ischemia resulting from cardiac arrest to irreversibly damage the organs is considerable. Moreover, graft preservation issues and organizational problems often worsen the dangerous effects of warm ischemia. Ex-Vivo Lung Perfusion (EVLP) enables to evaluate and recondition lungs whose functionality is doubtful, as well as to overcome the difficulties related to time and logistics. Methods: We report the case of uncontrolled DCD lungs successfully treated with an exceptionally prolonged EVLP. Since the donor’s blood count and liver biopsy showed signs of a possible leukaemia, EVLP was protracted up to seventeen hours while waiting for immunohistochemical analyses to rule out this diagnosis; eventually, the results came back negative and lungs were judged suitable for transplantation. Results: The recipient was a 32-year old male with cystic fibrosis, colonized by Pandoraea pnomenusa. Bilateral transplantation required central extracorporeal membrane oxygenation. The patient was extubated after 36 hours and was discharged 21 days after the operation. Despite early recolonization by Pandoraea pnomenusa and airway complications requiring pneumatic dilatation, he is alive and has a satisfactory respiratory function 15 months after transplantation. Conclusions: Uncontrolled DCD represents a challenge due to both logistical issues and the complexity of grafts evaluation before procurement: EVLP with cellular perfusate could be a valuable tool to overcome these limits. Nonetheless, caution should be exercised when interpreting the effects of this technique on airway healing.

Published
2021

49. Chronic obstructive Eustachian tube dysfunction: CT assessment with Valsalva maneuver and ETS-7 score

Author

Angeletti, Diletta, primary, Pace, Annalisa, additional, Iannella, Giannicola, additional, Rossetti, Valeria, additional, Colizza, Andrea, additional, Visconti, Irene Claudia, additional, Gulotta, Giampiero, additional, Messineo, Daniela, additional, de Vincentiis, Marco, additional, Greco, Antonio, additional, D’Ambrosio, Ferdinando, additional, and Magliulo, Giuseppe, additional

Published
2021
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50. Impact of bone-active drugs and underlying disease on bone health after lung transplantation: A longitudinal study

Author

Grassi Giorgia, Rosso Lorenzo, Letizia Corinna Morlacchi, Blasi Francesco, Chiodini Iacopo, Cairoli Elisa, Arosio Maura, Nosotti Mario, Rossetti Valeria, Righi Ilaria, and Eller-Vainicher Cristina

Subjects
Pulmonary and Respiratory Medicine, Adult, Male, Longitudinal study, medicine.medical_specialty, Cystic Fibrosis, medicine.medical_treatment, Urology, Cystic fibrosis, Bone health, Fractures, Bone, Trabecular bone score, Bone Density, Medicine, Lung transplantation, Humans, Femur, Longitudinal Studies, Prospective Studies, Bone mineral, Bone Density Conservation Agents, business.industry, Incidence (epidemiology), Middle Aged, medicine.disease, Pediatrics, Perinatology and Child Health, Cancellous Bone, Female, business, Lung Transplantation
Abstract

Introduction the effect of bone-active drugs on the risk of fragility fractures (Fx), bone mineral density (BMD) and trabecular bone score (TBS) changes in patients receiving lung transplantation (LTx) is largely unknown. This study assessed the bone-active drugs effect in patients undergoing LTx both with (CF) and without (nCF) cystic-fibrosis. Methods We evaluated incident Fx, both clinical and morphometric vertebral Fx by spinal X-ray, BMD and trabecular bone score (TBS) in 117 patients (CF=50, nCF n = 67) before and 24-months after LTx. A bone-active therapy was proposed to all LTx candidates. Results 83.8% of patients started a bone-active drug. Lumbar-spine (LS) T-score improved significantly only in treated patients (-1.4 ± 1.0 vs -2.0±1.0, p = 0.0001), whereas femur BMD and TBS remained stable in treated and not treated subjects. The rate of incident Fx was 15.3%, with no difference between treated and not treated patients. After LTx, LS T-score improved significantly only in nCF group (-1.3 ± 1.0 vs -1.8 ± 1.1, p = 0.0001), while femur remained stable in both nCF and CF groups. Patients with CF showed a significant Z-TBS increase (-3.6 ± 1.7 vs -3.0 ± 1.7, p = 0.019) and a lower Fx incidence as compared with nCF patients (4.1% vs 24.2%, p =0.003). Incident Fx were associated with nCF diagnosis (OR 7.300, CI95% 1.385–38.461, p = 0.019) regardless of prevalent Fx, previous glucocorticoid therapy and bone-active therapy introduced at least 6 months before LTx. Conclusions A prompt medical intervention helps in preventing BMD loss after LTx. As compared with nCF patients, CF patients show a TBS increase and a lower Fx risk after LTx.

Published
2020

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