1. Genetic testing in couples undergoing assisted reproduction technique protocols
- Author
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Valentina Gatta, Ivana Antonucci, Rossella Giuliani, Giandomenico Palka, Anna Paola Scioletti, and Liborio Stuppia
- Subjects
Gynecology ,Infertility ,medicine.medical_specialty ,medicine.diagnostic_test ,Cytogenetic investigation ,Offspring ,media_common.quotation_subject ,Genetic counseling ,Biochemistry (medical) ,Biomedical Engineering ,General Medicine ,Biology ,medicine.disease ,Bioinformatics ,Cftr gene ,medicine ,Molecular Medicine ,Reproduction ,media_common ,Genetic testing - Abstract
Background: An increasing number of couples undergo assisted reproduction techniques (ART) to generate a child, with the risk of the transmission to the offspring of a genetic defect underlying the condition of infertility. Objective: To review the most common genetic causes of infertility and identify the appropriate genetic testing to be carried out to reduce the risk of genetic defect in the offspring. Method: Review of the literature in the field. Results/conclusion: Cytogenetic investigation and screening of the CFTR gene are the only genetics testing suggested in all the couples undergoing ART; other tests should be performed only in selected cases.
- Published
- 2009