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13. Impact of Overweight and Obesity on Disease Outcome in the Pediatric Swiss Inflammatory Bowel Disease Cohort

Author

von Graffenried, Thea, Schoepfer, Alain M., Rossel, Jean-Benoit, Greuter, Thomas, Safroneeva, Ekaterina, Godat, Sébastien, Henchoz, Sarah, Vavricka, Stephan R., Sokollik, Christiane, Spalinger, Johannes, Braegger, Christian P., Nydegger, Andreas, Abdelrahman, Karim, Ademi, Gentiana, Aepli, Patrick, Thomas, Amman, Anderegg, Claudia, Antonino, Anca-Teodora, Archanioti, Eva, Arrigoni, Eviano, de Jong, Diana Bakker, Balsiger, Bruno, Bastürk, Polat, Bauerfeind, Peter, Becocci, Andrea, Belli, Dominique, Bengoa, José M., Biedermann, Luc, Binek, Janek, Blattmann, Mirjam, Boehm, Stephan, Boldanova, Tujana, Borovicka, Jan, Braegger, Christian P., Brand, Stephan, Brügger, Lukas, Brunner, Simon, Bühr, Patrick, Burnand, Bernard, Burk, Sabine, Burri, Emanuel, Buyse, Sophie, Cao, Dahlia-Thao, Carstens, Ove, Criblez, Dominique H., Cunningham, Sophie, D’Angelo, Fabrizia, de Saussure, Philippe, Degen, Lukas, Delarive, Joakim, Doerig, Christopher, Dora, Barbara, Drerup, Susan, Egger, Mara, El-Wafa, Ali, Engelmann, Matthias, Felley, Christian, Fliegner, Markus, Fournier, Nicolas, Fraga, Montserrat, Franc, Yannick, Frei, Pascal, Frei, Remus, Fried, Michael, Froehlich, Florian, Furlano, Raoul Ivano, Garzoni, Luca, Geyer, Martin, Girard, Laurent, Girardin, Marc, Golay, Delphine, Good, Ignaz, Bigler, Ulrike Graf, Gysi, Beat, Haarer, Johannes, Halama, Marcel, Haldemann, Janine, Heer, Pius, Heimgartner, Benjamin, Helbling, Beat, Hengstler, Peter, Herzog, Denise, Hess, Cyrill, Heyland, Klaas, Hinterleitner, Thomas, Hirschi, Claudia, Hruz, Petr, Juillerat, Pascal, Khalid-de Bakker, Carolina, Kayser, Stephan, Keller, Céline, Knellwolf, Christina, Knoblauch, Christoph, Köhler, Henrik, Koller, Rebekka, Krieger, Claudia, Künzler, Patrizia, Kusche, Rachel, Lehmann, Frank Serge, Macpherson, Andrew, Maillard, Michel H., Manz, Michael, Marot, Astrid, Meier, Rémy, Meyenberger, Christa, Meyer, Pamela, Michetti, Pierre, Misselwitz, Benjamin, Mosler, Patrick, Mottet, Christian, Müller, Christoph, Müllhaupt, Beat, Musso, Leilla, Neagu, Michaela, Nichita, Cristina, Niess, Jan, Nydegger, Andreas, Obialo, Nicole, Ollo, Diana, Oropesa, Cassandra, Peter, Ulrich, Peternac, Daniel, Petit, Laetitia Marie, Pittet, Valérie, Pohl, Daniel, Porzner, Marc, Preissler, Claudia, Raschle, Nadia, Rentsch, Ronald, Restellini, Alexandre, Restellini, Sophie, Richterich, Jean-Pierre, Ris, Frederic, Risti, Branislav, Ritz, Marc Alain, Rogler, Gerhard, Röhrich, Nina, Rossel, Jean-Benoît, Rueger, Vanessa, Rusticeanu, Monica, Sagmeister, Markus, Saner, Gaby, Sauter, Bernhard, Sawatzki, Mikael, Scharl, Michael, Schelling, Martin, Schibli, Susanne, Schlauri, Hugo, Schluckebier, Dominique, Schmid, Daniela, Schmid, Sybille, Schnegg, Jean-François, Schoepfer, Alain, Seematter, Vivianne, Seibold, Frank, Seirafi, Mariam, Semadeni, Gian-Marco, Senning, Arne, Sokollik, Christiane, Sommer, Joachim, Spalinger, Johannes, Spangenberger, Holger, Stadler, Philippe, Staub, Peter, Staudenmann, Dominic, Stenz, Volker, Steuerwald, Michael, Straumann, Alex, Stulz, Andreas, Sulz, Michael, Tatu, Aurora, Tempia-Caliera, Michela, Thorens, Joël, Truninger, Kaspar, Tutuian, Radu, Urfer, Patrick, Vavricka, Stephan, Viani, Francesco, Vögtlin, Jürg, Von Känel, Roland, Vouillamoz, Dominique, Vulliamy, Rachel, Wiesel, Paul, Wiest, Reiner, Wöhrle, Stefanie, Zamora, Samuel, Zander, Silvan, Zeitz, Jonas, and Zimmermann, Dorothee

Published
2022
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14. Differences in Outcomes Reported by Patients With Inflammatory Bowel Diseases vs Their Health Care Professionals

Author

Anderegg, Claudia, Bauerfeind, Peter, Beglinger, Christoph, Begré, Stefan, Belli, Dominique, Bengoa, José M., Biedermann, Luc, Bigler, Beat, Binek, Janek, Blattmann, Mirjam, Boehm, Stephan, Borovicka, Jan, Braegger, Christian P., Brunner, Nora, Bühr, Patrick, Burnand, Bernard, Burri, Emanuel, Buyse, Sophie, Cremer, Matthias, Criblez, Dominique H., de Saussure, Philippe, Degen, Lukas, Delarive, Joakim, Doerig, Christopher, Dora, Barbara, Dorta, Gian, Egger, Mara, Ehmann, Tobias, El-Wafa, Ali, Engelmann, Matthias, Ezri, Jessica, Felley, Christian, Fliegner, Markus, Fournier, Nicolas, Fraga, Montserrat, Frei, Pascal, Frei, Remus, Fried, Michael, Froehlich, Florian, Funk, Christian, Furlano, Raoul Ivano, Gallot-Lavallée, Suzanne, Geyer, Martin, Girardin, Marc, Golay, Delphine, Grandinetti, Tanja, Gysi, Beat, Haack, Horst, Haarer, Johannes, Helbling, Beat, Hengstler, Peter, Herzog, Denise, Hess, Cyrill, Heyland, Klaas, Hinterleitner, Thomas, Hiroz, Philippe, Hirschi, Claudia, Hruz, Petr, Iwata, Rika, Jost, Res, Juillerat, Pascal, Keller, Céline, Knellwolf, Christina, Knoblauch, Christoph, Köhler, Henrik, Koller, Rebekka, Krieger-Grübel, Claudia, Kullak-Ublick, Gerd, Künzler, Patrizia, Landolt, Markus, Lange, Rupprecht, Lehmann, Frank Serge, Macpherson, Andrew, Maerten, Philippe, Maillard, Michel H., Manser, Christine, Manz, Michael, Marbet, Urs, Marx, George, Matter, Christoph, Meier, Rémy, Mendanova, Martina, Michetti, Pierre, Misselwitz, Benjamin, Morell, Bernhard, Mosler, Patrick, Mottet, Christian, Müller, Christoph, Müller, Pascal, Müllhaupt, Beat, Münger-Beyeler, Claudia, Musso, Leilla, Nagy, Andreas, Neagu, Michaela, Nichita, Cristina, Niess, Jan, Nydegger, Andreas, Obialo, Nicole, Oneta, Carl, Oropesa, Cassandra, Peter, Ueli, Peternac, Daniel, Petit, Laetitia Marie, Piccoli-Gfeller, Franziska, Pilz, Julia Beatrice, Pittet, Valérie, Raschle, Nadia, Rentsch, Ronald, Restellini, Sophie, Richterich, Jean-Pierre, Rihs, Sylvia, Ritz, Marc Alain, Roduit, Jocelyn, Rogler, Daniela, Rogler, Gerhard, Rossel, Jean-Benoît, Rueger, Vanessa, Saner, Gaby, Sauter, Bernhard, Sawatzki, Mikael, Schäppi, Michela, Scharl, Michael, Scharl, Sylvie, Schelling, Martin, Schibli, Susanne, Schlauri, Hugo, Uebelhart, Sybille Schmid, Schnegg, Jean-François, Schoepfer, Alain, Seibold, Frank, Seirafi, Mariam, Semadeni, Gian-Marco, Semela, David, Senning, Arne, Sidler, Marc, Sokollik, Christiane, Spalinger, Johannes, Spangenberger, Holger, Stadler, Philippe, Steuerwald, Michael, Straumann, Alex, Straumann-Funk, Bigna, Sulz, Michael, Suter, Alexandra, Thorens, Joël, Tiedemann, Sarah, Tutuian, Radu, Vavricka, Stephan, Viani, Francesco, Vögtlin, Jürg, Von Känel, Roland, Vonlaufen, Alain, Vouillamoz, Dominique, Vulliamy, Rachel, Wermuth, Jürg, Werner, Helene, Wiesel, Paul, Wiest, Reiner, Wylie, Tina, Zeitz, Jonas, Zimmermann, Dorothee, Pittet, Valérie E.H., and Simonson, Thomas

Published
2019
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15. Long-Term Outcome of Surgery for Perianal Crohn's Fistula.

Author

Schaad, Marie, Schoepfer, Alain, Rossel, Jean-Benoît, Barry, Mamadou Pathé, Rogler, Gerhard, and Hahnloser, Dieter

Subjects
FISTULA, INFLAMMATORY bowel diseases, FIBRIN tissue adhesive, CROHN'S disease
Abstract

Background and Objectives: Patients with perianal Crohn's (CD) fistula often need repetitive surgeries and none of the established techniques was shown to be superior or preferable. Furthermore, the long-term outcome of fistula Seton drainage is not well described. The aims of this study were to analyze the long-term healing and recurrence rate of CD perianal fistulas in a large patient cohort. Materials and Methods: Database analysis of the Swiss IBD (Inflammatory Bowel Disease) cohort study. Results: 365 perianal fistula patients with 576 surgical interventions and a median follow-up of 7.5 years (0–12.6) were analyzed. 39.7% of patients required more than one procedure. The first surgical interventions were fistulectomies ± mucosal sliding flap (59.2%), Seton drainage (29.6%), fistula plugs or fibrin glue installations (2.5%) and combined procedures (8.8%). Fistulectomy patients required no more surgery in 69%, one additional surgery in 25% and more than one additional surgery in 6%, with closure rates at 7.5 years follow-up of 77.1%, 74.1% and 66.7%, respectively. In patients with Seton drainage as index surgery, 52% required no more surgery, and over 75% achieved fistula closure after 10 years. Conclusions: First-line fistulectomies, when feasible, achieved the highest healing rates, but one-third of patients required additional surgeries, and one-fourth of patients will remain with a fistula at 10 years. Initial Seton drainage and concurrent medical therapy can achieve fistula closure in 75%. However, in 50% of patients, more surgeries are needed, and fistula closure is achieved in only two-thirds of patients. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Symptoms of Depression and Anxiety Are Independently Associated With Clinical Recurrence of Inflammatory Bowel Disease

Author

Anderegg, Claudia, Bauerfeind, Peter, Beglinger, Christoph, Begré, Stefan, Belli, Dominique, Bengoa, José M., Biedermann, Luc, Bigler, Beat, Binek, Janek, Blattmann, Mirjam, Boehm, Stephan, Borovicka, Jan, Braegger, Christian P., Brunner, Nora, Bühr, Patrick, Burnand, Bernard, Burri, Emanuel, Buyse, Sophie, Cremer, Matthias, Criblez, Dominique H., de Saussure, Philippe, Degen, Lukas, Delarive, Joakim, Doerig, Christopher, Dora, Barbara, Dorta, Gian, Egger, Mara, Ehmann, Tobias, El-Wafa, Ali, Engelmann, Matthias, Ezri, Jessica, Felley, Christian, Fliegner, Markus, Fournier, Nicolas, Fraga, Montserrat, Frei, Pascal, Frei, Remus, Fried, Michael, Froehlich, Florian, Funk, Christian, Ivano Furlano, Raoul, Gallot-Lavallée, Suzanne, Geyer, Martin, Girardin, Marc, Golay, Delphine, Grandinetti, Tanja, Gysi, Beat, Haack, Horst, Haarer, Johannes, Helbling, Beat, Hengstler, Peter, Herzog, Denise, Hess, Cyrill, Heyland, Klaas, Hinterleitner, Thomas, Hiroz, Philippe, Hirschi, Claudia, Hruz, Petr, Iwata, Rika, Jost, Res, Juillerat, Pascal, Kessler Brondolo, Vera, Knellwolf, Christina, Knoblauch, Christoph, Köhler, Henrik, Koller, Rebekka, Krieger-Grübel, Claudia, Kullak-Ublick, Gerd, Künzler, Patrizia, Landolt, Markus, Lange, Rupprecht, Serge Lehmann, Frank, Macpherson, Andrew, Maerten, Philippe, Maillard, Michel H., Manser, Christine, Manz, Michael, Marbet, Urs, Marx, George, Matter, Christoph, McLin, Valérie, Meier, Rémy, Mendanova, Martina, Meyenberger, Christa, Michetti, Pierre, Misselwitz, Benjamin, Moradpour, Darius, Morell, Bernhard, Mosler, Patrick, Mottet, Christian, Müller, Christoph, Müller, Pascal, Müllhaupt, Beat, Münger-Beyeler, Claudia, Musso, Leilla, Nagy, Andreas, Neagu, Michaela, Nichita, Cristina, Niess, Jan, Noël, Natacha, Nydegger, Andreas, Obialo, Nicole, Oneta, Carl, Oropesa, Cassandra, Peter, Ueli, Peternac, Daniel, Marie Petit, Laetitia, Piccoli-Gfeller, Franziska, Beatrice Pilz, Julia, Pittet, Valérie, Raschle, Nadia, Rentsch, Ronald, Restellini, Sophie, Richterich, Jean-Pierre, Rihs, Sylvia, Alain Ritz, Marc, Roduit, Jocelyn, Rogler, Daniela, Rogler, Gerhard, Rossel, Jean-Benoît, Sagmeister, Markus, Saner, Gaby, Sauter, Bernhard, Sawatzki, Mikael, Schäppi, Michela, Scharl, Michael, Schelling, Martin, Schibli, Susanne, Schlauri, Hugo, Schmid Uebelhart, Sybille, Schnegg, Jean-François, Schoepfer, Alain, Seibold, Frank, Seirafi, Mariam, Semadeni, Gian-Marco, Semela, David, Senning, Arne, Sidler, Marc, Sokollik, Christiane, Spalinger, Johannes, Spangenberger, Holger, Stadler, Philippe, Steuerwald, Michael, Straumann, Alex, Straumann-Funk, Bigna, Sulz, Michael, Thorens, Joël, Tiedemann, Sarah, Tutuian, Radu, Vavricka, Stephan, Viani, Francesco, Vögtlin, Jürg, Von Känel, Roland, Vonlaufen, Alain, Vouillamoz, Dominique, Vulliamy, Rachel, Wermuth, Jürg, Werner, Helene, Wiesel, Paul, Wiest, Reiner, Wylie, Tina, Zeitz, Jonas, Zimmermann, Dorothee, Mikocka-Walus, Antonina, Pittet, Valerie, and von Känel, Roland

Published
2016
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20. The Relevance of Vitamin and Iron Deficiency in Patients with Inflammatory Bowel Diseases in Patients of the Swiss IBD Cohort

Author

Madanchi, Matiar, Fagagnini, Stefania, Fournier, Nicolas, Biedermann, Luc, Zeitz, Jonas, Battegay, Edouard, Zimmerli, Lukas, Vavricka, Stephan R, Rogler, Gerhard, Scharl, Michael, Anderegg, Claudia, Bauerfeind, Peter, Beglinger, Christoph, Begré, Stefan, Belli, Dominique, Bengoa, José M, Biedermann, Luc, Bigler, Beat, Binek, Janek, Blattmann, Mirjam, Boehm, Stephan, Borovicka, Jan, Braegger, Christian P, Brunner, Nora, Bühr, Patrick, Burnand, Bernard, Burri, Emanuel, Buyse, Sophie, Cremer, Matthias, Criblez, Dominique H, Saussure, Philippe de, Degen, Lukas, Delarive, Joakim, Doerig, Christopher, Dora, Barbara, Dorta, Gian, Egger, Mara, Ehmann, Tobias, El-Wafa, Ali, Engelmann, Matthias, Ezri, Jessica, Felley, Christian, Fliegner, Markus, Fournier, Nicolas, Fraga, Montserrat, Frei, Pascal, Frei, Remus, Fried, Michael, Froehlich, Florian, Funk, Christian, Furlano, Raoul Ivano, Gallot-Lavallée, Suzanne, Geyer, Martin, Girardin, Marc, Golay, Delphine, Grandinetti, Tanja, Gysi, Beat, Haack, Horst, Haarer, Johannes, Helbling, Beat, Hengstler, Peter, Herzog, Denise, Hess, Cyrill, Heyland, Klaas, Hinterleitner, Thomas, Hiroz, Philippe, Hirschi, Claudia, Hruz, Petr, Iwata, Rika, Jost, Res, Juillerat, Pascal, Brondolo, Vera Kessler, Knellwolf, Christina, Knoblauch, Christoph, Köhler, Henrik, Koller, Rebekka, Krieger-Grübel, Claudia, Kullak-Ublick, Gerd, Künzler, Patrizia, Landolt, Markus, Lange, Rupprecht, Lehmann, Frank Serge, Macpherson, Andrew, Maerten, Philippe, Maillard, Michel H, Manser, Christine, Manz, Michael, Marbet, Urs, Marx, George, Matter, Christoph, McLin, Valérie, Meier, Rémy, Mendanova, Martina, Meyenberger, Christa, Michetti, Pierre, Misselwitz, Benjamin, Moradpour, Darius, Morell, Bernhard, Mosler, Patrick, Mottet, Christian, Müller, Christoph, Müller, Pascal, Müllhaupt, Beat, Münger-Beyeler, Claudia, Musso, Leilla, Nagy, Andreas, Neagu, Michaela, Nichita, Cristina, Niess, Jan, Noël, Natacha, Nydegger, Andreas, Obialo, Nicole, Oneta, Carl, Oropesa, Cassandra, Peter, Ueli, Peternac, Daniel, Petit, Laetitia Marie, Piccoli-Gfeller, Franziska, Pilz, Julia Beatrice, Pittet, Valérie, Raschle, Nadia, Rentsch, Ronald, Restellini, Sophie, Richterich, Jean-Pierre, Rihs, Sylvia, Ritz, Marc Alain, Roduit, Jocelyn, Rogler, Daniela, Rogler, Gerhard, Rossel, Jean-Benoît, Sagmeister, Markus, Saner, Gaby, Sauter, Bernhard, Sawatzki, Mikael, Schäppi, Michela, Scharl, Michael, Schelling, Martin, Schibli, Susanne, Schlauri, Hugo, Uebelhart, Sybille Schmid, Schnegg, Jean-François, Schoepfer, Alain, Seibold, Frank, Seirafi, Mariam, Semadeni, Gian-Marco, Semela, David, Senning, Arne, Sidler, Marc, Sokollik, Christiane, Spalinger, Johannes, Spangenberger, Holger, Stadler, Philippe, Steuerwald, Michael, Straumann, Alex, Straumann-Funk, Bigna, Sulz, Michael, Thorens, Joël, Tiedemann, Sarah, Tutuian, Radu, Vavricka, Stephan, Viani, Francesco, Vögtlin, Jürg, Känel, Roland Von, Vonlaufen, Alain, Vouillamoz, Dominique, Vulliamy, Rachel, Wermuth, Jürg, Werner, Helene, Wiesel, Paul, Wiest, Reiner, Wylie, Tina, Zeitz, Jonas, and Zimmermann, Dorothee

Published
2018
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21. The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation

Author

Tcymbarevich, Irina V., Eloranta, Jyrki J., Rossel, Jean-Benoît, Obialo, Nicole, Spalinger, Marianne, Cosin-Roger, Jesus, Lang, Silvia, Kullak-Ublick, Gerd A., Wagner, Carsten A., Scharl, Michael, Seuwen, Klaus, Ruiz, Pedro A., Rogler, Gerhard, de Vallière, Cheryl, Misselwitz, Benjamin, and on behalf of the Swiss IBD Cohort Study Group

Published
2019
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22. Genetic polymorphisms associated with smoking behaviour predict the risk of surgery in patients with Crohnʼs disease

Author

Lang, B. M., Biedermann, L., van Haaften, W. T., de Vallière, C., Schuurmans, M., Begré, S., Zeitz, J., Scharl, M., Turina, M., Greuter, T., Schreiner, P., Heinrich, H., Kuntzen, T., Vavricka, S. R., Rogler, G., Beerenwinkel, N., Misselwitz, B., Anderegg, Claudia, Bauerfeind, Peter, Beglinger, Christoph, Begré, Stefan, Bengoa, José M., Biedermann, Luc, Bigler, Beat, Binek, Janek, Blattmann, Mirjam, Boehm, Stephan, Borovicka, Jan, Braegger, Christian P., Brunner, Nora, Bühr, Patrick, Burnand, Bernard, Burri, Emanuel, Buyse, Sophie, Cremer, Matthias, Criblez, Dominique H., de Saussure, Philippe, Degen, Lukas, Delarive, Joakim, Doerig, Christopher, Dora, Barbara, Dorta, Gian, Egger, Mara, Ehmann, Tobias, El‐Wafa, Ali, Engelmann, Matthias, Ezri, a, Felley, Christian, Fliegner, Markus, Fournier, Nicolas, Fraga, Montserrat, Frei, Pascal, Frei, Remus, Fried, Michael, Froehlich, Florian, Funk, Christian, Furlano, Raoul Ivano, Gallot‐Lavallée, Suzanne, Geyer, Martin, Girardin, Marc, Golay, Delphine, Grandinetti, Tanja, Gysi, Beat, Haack, Horst, Haarer, Johannes, Helbling, Beat, Hengstler, Peter, Herzog, Denise, Hess, Cyrill, Heyland, Klaas, Hinterleitner, Thomas, Hiroz, Philippe, Hirschi, Claudia, Hruz, Petr, Iwata, Rika, Jost, Res, Juillerat, Pascal, Kessler Brondolo, Vera, Knellwolf, Christina, Knoblauch, Christoph, Köhler, Henrik, Koller, Rebekka, Krieger‐Grübel, Claudia, Kullak‐Ublick, Gerd, Künzler, Patrizia, Landolt, Markus, Lange, Rupprecht, Lehmann, Frank Serge, Macpherson, Andrew, Maerten, Philippe, Maillard, Michel H., Manser, Christine, Manz, Michael, Marbet, Urs, Marx, George, Matter, Christoph, McLin, Valérie, Meier, Rémy, Mendanova, Martina, Meyenberger, Christa, Michetti, Pierre, Misselwitz, Benjamin, Moradpour, Darius, Morell, Bernhard, Mosler, Patrick, Mottet, Christian, Müller, Christoph, Müller, Pascal, Müllhaupt, Beat, Münger‐Beyeler, Claudia, Musso, Leilla, Nagy, Andreas, Neagu, Michaela, Nichita, Cristina, Niess, Jan, Noël, Natacha, Nydegger, Andreas, Obialo, Nicole, Oneta, Carl, Oropesa, Cassandra, Peter, Ueli, Peternac, Daniel, Petit, Laetitia Marie, Piccoli‐Gfeller, Franziska, Pilz, Julia Beatrice, Pittet, Valérie, Raschle, Nadia, Rentsch, Ronald, Restellini, Sophie, Richterich, Jean‐Pierre, Rihs, Sylvia, Ritz, Marc Alain, Roduit, Jocelyn, Rogler, Daniela, Rogler, Gerhard, Rossel, Jean‐Benoît, Sagmeister, Markus, Saner, Gaby, Sauter, Bernhard, Sawatzki, Mikael, Schäppi, Michela, Scharl, Michael, Schelling, Martin, Schibli, Susanne, Schlauri, Hugo, Uebelhart, Sybille Schmid, Schnegg, Jean‐François, Schoepfer, Alain, Seibold, Frank, Seirafi, Mariam, Semadeni, Gian‐Marco, Semela, David, Senning, Arne, Sidler, Marc, Sokollik, Christiane, Spalinger, Johannes, Spangenberger, Holger, Stadler, Philippe, Steuerwald, Michael, Straumann, Alex, Straumann‐Funk, Bigna, Sulz, Michael, Thorens, Joël, Tiedemann, Sarah, Tutuian, Radu, Vavricka, Stephan, Viani, Francesco, Vögtlin, Jürg, Von Känel, Roland, Vonlaufen, Alain, Vouillamoz, Dominique, Vulliamy, Rachel, Wermuth, Jürg, Werner, Helene, Wiesel, Paul, Wiest, Reiner, Wylie, Tina, Zeitz, Jonas, and Zimmermann, Dorothee

Published
2018
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23. Risk stratification for hospital-acquired venous thromboembolism in medical patients (RISE): Protocol for a prospective cohort study

Author

Choffat, Damien, primary, Farhoumand, Pauline Darbellay, additional, Jaccard, Evrim, additional, de la Harpe, Roxane, additional, Kraege, Vanessa, additional, Benmachiche, Malik, additional, Gerber, Christel, additional, Leuzinger, Salomé, additional, Podmore, Clara, additional, Truong, Minh Khoa, additional, Dumans-Louis, Céline, additional, Marti, Christophe, additional, Reny, Jean-Luc, additional, Aujesky, Drahomir, additional, Rakovic, Damiana, additional, Limacher, Andreas, additional, Rossel, Jean-Benoît, additional, Baumgartner, Christine, additional, and Méan, Marie, additional

Published
2022
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25. Effectiveness of golimumab in patients with ulcerative colitis: results of a real-life study in Switzerland

Author

Perrig, Kathrin; https://orcid.org/0000-0002-8730-954X, Krupka, Niklas, Jordi, Sebastian Bruno Ulrich, Rossel, Jean-Benoît, Biedermann, Luc; https://orcid.org/0000-0003-0824-4125, Greuter, Thomas, Schreiner, Philipp, Vavricka, Stephan R, Juillerat, Pascal, Burri, Emanuel, Zimmermann, Dorothee, Maillard, Michel H, Sulz, Michael Christian, Brand, Stephan, Rogler, Gerhard, Misselwitz, Benjamin, Perrig, Kathrin; https://orcid.org/0000-0002-8730-954X, Krupka, Niklas, Jordi, Sebastian Bruno Ulrich, Rossel, Jean-Benoît, Biedermann, Luc; https://orcid.org/0000-0003-0824-4125, Greuter, Thomas, Schreiner, Philipp, Vavricka, Stephan R, Juillerat, Pascal, Burri, Emanuel, Zimmermann, Dorothee, Maillard, Michel H, Sulz, Michael Christian, Brand, Stephan, Rogler, Gerhard, and Misselwitz, Benjamin

Abstract

Background: Tumor necrosis factor (TNF) inhibitors have improved treatment of ulcerative colitis (UC), but loss of response remains a frequent problem. The anti-TNF agent, golimumab, was approved in Switzerland for the treatment of UC in 2014. This study aims to summarize the experience of golimumab in a real-world setting in Switzerland. Methods: We analyzed real-world data from 1769 UC patients from the Swiss Inflammatory Bowel Disease Cohort (SIBDC) study and performed a chart review of golimumab-treated patients. We extracted the partial Mayo score at t0 (baseline), t1 (2-16 weeks), t2 (17-35 weeks), and t3 (36-89 weeks). The primary endpoint was clinical response at t1, defined as marked improvement in partial Mayo score and objective parameters. Clinical remission was defined as resolution of symptoms and normalization of objective parameters. Results: Our chart review included 103 UC patients with golimumab treatment (5.8% of all SIBDC UC patients); only 16 (15.5%) were anti-TNF naïve. Sixty-three patients remained on golimumab (61.2%) after 180 days, 51 (44.7%) after 365 days, and 34 (33%) after 630 days after the start of treatment. Upon golimumab treatment, the partial Mayo score decreased from 4 [interquartile range (IQR): 2-6] at t0 to 2 (IQR: 0-4) at t1, 1 (IQR: 0-3.5) at t2, and 1 (IQR: 0-3) at t3 (p < 0.001 for all comparisons with t0). The primary endpoint, clinical response at t1, could be evaluated in 52 patients and was met in 15 individuals (28.8%). Clinical remission at t1 was observed in 8 out of 52 patients (15.4%). Golimumab was generally well tolerated, one patient developed meningitis. The most frequent reasons to stop treatment were primary and secondary non-response. Conclusion: Golimumab was used in 5.8% of Swiss UC patients, mainly in biologic-experienced individuals. Golimumab treatment was associated with a sustained reduction of symptoms and clinical response in approximately 30% of patients.[ClinicalTrials.gov identifier: NCT0048863

Published
2022

26. Symptoms of Depression and Anxiety Are Independently Associated With Clinical Recurrence of Inflammatory Bowel Disease

Author

Mikocka-Walus, Antonina, Pittet, Valerie, Rossel, Jean-Benoît, von Känel, Roland, Anderegg, Claudia, Bauerfeind, Peter, Beglinger, Christoph, Begré, Stefan, Belli, Dominique, Bengoa, José M., Biedermann, Luc, Bigler, Beat, Binek, Janek, Blattmann, Mirjam, Boehm, Stephan, Borovicka, Jan, Braegger, Christian P., Brunner, Nora, Bühr, Patrick, Burnand, Bernard, Burri, Emanuel, Buyse, Sophie, Cremer, Matthias, Criblez, Dominique H., de Saussure, Philippe, Degen, Lukas, Delarive, Joakim, Doerig, Christopher, Dora, Barbara, Dorta, Gian, Egger, Mara, Ehmann, Tobias, El-Wafa, Ali, Engelmann, Matthias, Ezri, Jessica, Felley, Christian, Fliegner, Markus, Fournier, Nicolas, Fraga, Montserrat, Frei, Pascal, Frei, Remus, Fried, Michael, Froehlich, Florian, Funk, Christian, Ivano Furlano, Raoul, Gallot-Lavallée, Suzanne, Geyer, Martin, Girardin, Marc, Golay, Delphine, Grandinetti, Tanja, Gysi, Beat, Haack, Horst, Haarer, Johannes, Helbling, Beat, Hengstler, Peter, Herzog, Denise, Hess, Cyrill, Heyland, Klaas, Hinterleitner, Thomas, Hiroz, Philippe, Hirschi, Claudia, Hruz, Petr, Iwata, Rika, Jost, Res, Juillerat, Pascal, Kessler Brondolo, Vera, Knellwolf, Christina, Knoblauch, Christoph, Köhler, Henrik, Koller, Rebekka, Krieger-Grübel, Claudia, Kullak-Ublick, Gerd, Künzler, Patrizia, Landolt, Markus, Lange, Rupprecht, Serge Lehmann, Frank, Macpherson, Andrew, Maerten, Philippe, Maillard, Michel H., Manser, Christine, Manz, Michael, Marbet, Urs, Marx, George, Matter, Christoph, McLin, Valérie, Meier, Rémy, Mendanova, Martina, Meyenberger, Christa, Michetti, Pierre, Misselwitz, Benjamin, Moradpour, Darius, Morell, Bernhard, Mosler, Patrick, Mottet, Christian, Müller, Christoph, Müller, Pascal, Müllhaupt, Beat, Münger-Beyeler, Claudia, Musso, Leilla, Nagy, Andreas, Neagu, Michaela, Nichita, Cristina, Niess, Jan, Noël, Natacha, Nydegger, Andreas, Obialo, Nicole, Oneta, Carl, Oropesa, Cassandra, Peter, Ueli, Peternac, Daniel, Marie Petit, Laetitia, Piccoli-Gfeller, Franziska, Beatrice Pilz, Julia, Pittet, Valérie, Raschle, Nadia, Rentsch, Ronald, Restellini, Sophie, Richterich, Jean-Pierre, Rihs, Sylvia, Alain Ritz, Marc, Roduit, Jocelyn, Rogler, Daniela, Rogler, Gerhard, Rossel, Jean-Benoît, Sagmeister, Markus, Saner, Gaby, Sauter, Bernhard, Sawatzki, Mikael, Schäppi, Michela, Scharl, Michael, Schelling, Martin, Schibli, Susanne, Schlauri, Hugo, Schmid Uebelhart, Sybille, Schnegg, Jean-François, Schoepfer, Alain, Seibold, Frank, Seirafi, Mariam, Semadeni, Gian-Marco, Semela, David, Senning, Arne, Sidler, Marc, Sokollik, Christiane, Spalinger, Johannes, Spangenberger, Holger, Stadler, Philippe, Steuerwald, Michael, Straumann, Alex, Straumann-Funk, Bigna, Sulz, Michael, Thorens, Joël, Tiedemann, Sarah, Tutuian, Radu, Vavricka, Stephan, Viani, Francesco, Vögtlin, Jürg, Von Känel, Roland, Vonlaufen, Alain, Vouillamoz, Dominique, Vulliamy, Rachel, Wermuth, Jürg, Werner, Helene, Wiesel, Paul, Wiest, Reiner, Wylie, Tina, Zeitz, Jonas, and Zimmermann, Dorothee

Published
2016
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31. Effectiveness of golimumab in patients with ulcerative colitis: results of a real-life study in Switzerland

Author

Perrig, Kathrin, primary, Krupka, Niklas, additional, Jordi, Sebastian Bruno Ulrich, additional, Rossel, Jean-Benoît, additional, Biedermann, Luc, additional, Greuter, Thomas, additional, Schreiner, Philipp, additional, Vavricka, Stephan R., additional, Juillerat, Pascal, additional, Burri, Emanuel, additional, Zimmermann, Dorothee, additional, Maillard, Michel H., additional, Sulz, Michael Christian, additional, Brand, Stephan, additional, Rogler, Gerhard, additional, and Misselwitz, Benjamin, additional

Published
2022
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32. A single nucleotide polymorphism in the gene for GPR183 increases its surface expression on blood lymphocytes of patients with inflammatory bowel disease

Author

Ruiz, Florian, Wyss, Annika, Rossel, Jean-Benoît, Sulz, Michael Christian, Brand, Stephan, Moncsek, Anja, Mertens, Joachim C, Roth, René, Clottu, Aurélie S, Burri, Emanuel, Juillerat, Pascal, Biedermann, Luc, Greuter, Thomas, Rogler, Gerhard, Pot, Caroline, Misselwitz, Benjamin, Swiss IBD Cohort Study Group, University of Zurich, and Pot, Caroline

Subjects
10219 Clinic for Gastroenterology and Hepatology, 3004 Pharmacology, 610 Medicine & health
Published
2021
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35. sj-docx-1-tag-10.1177_17562848211033763 – Supplemental material for Effects of anti-TNF therapy and immunomodulators on anxiety and depressive symptoms in patients with inflammatory bowel disease: a 5-year analysis

Author

Siebenhüner, Alexander R., Rossel, Jean-Benoît, Schreiner, Philipp, Butter, Matthias, Greuter, Thomas, Krupka, Niklas, Jordi, Sebastian B. U., Biedermann, Luc, Rogler, Gerhard, Misselwitz, Benjamin, and von Känel, Roland

Subjects
FOS: Clinical medicine, 111199 Nutrition and Dietetics not elsewhere classified, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-docx-1-tag-10.1177_17562848211033763 for Effects of anti-TNF therapy and immunomodulators on anxiety and depressive symptoms in patients with inflammatory bowel disease: a 5-year analysis by Alexander R. Siebenhüner, Jean-Benoît Rossel, Philipp Schreiner, Matthias Butter, Thomas Greuter, Niklas Krupka, Sebastian B. U. Jordi, Luc Biedermann, Gerhard Rogler, Benjamin Misselwitz, Roland von Känel, Karim Abdelrahman, Gentiana Ademi, Patrick Aepli, Amman Thomas, Claudia Anderegg, Anca-Teodora Antonino, Eva Archanioti, Eviano Arrigoni, Nurullah Aslan, Diana Bakker de Jong, Bruno Balsiger, Mamadou-Pathé Barry, Polat Bastürk, Peter Bauerfeind, Andrea Becocci, José M. Bengoa, Luc Biedermann, Janek Binek, Mirjam Blattmann, Stephan Boehm, Tujana Boldanova, Jan Borovicka, Christian P. Braegger, Stephan Brand, Francisco Bravo, Lukas Brügger, Simon Brunner, Patrick Bühr, Sabine Burk, Emanuel Burri, Matthias Butter, Sophie Buyse, Dahlia-Thao Cao, Ove Carstens, Dominique H. Criblez, Fabrizia D’Angelo, Philippe de Saussure, Lukas Degen, Joakim Delarive, Christopher Doerig, Barbara Dora, Susan Drerup, Carole Ducrey, Ali El-Wafa, Matthias Engelmann, Aude Erdmann-Voisin, Christian Felley, Markus Fliegner, Montserrat Fraga, Yannick Franc, Pascal Frei, Remus Frei, Michael Fried, Florian Froehlich, Raoul Ivano Furlano, Luca Garzoni, Martin Geyer, Marc Girardin, Delphine Golay, Ignaz Good, Ulrike Graf Bigler, Sébastien Godat, Thomas Greuter, Beat Gysi, Johannes Haarer, Marcel Halama, Janine Haldemann, Pius Heer, Benjamin Heimgartner, Beat Helbling, Peter Hengstler, Denise Herzog, Cyrill Hess, Roxane Hessler, Klaas Heyland, Thomas Hinterleitner, Claudia Hirschi, Petr Hruz, Pascal Juillerat, Ioannis Kapoglou, Stephan Kayser, Céline Keller, Carolina Khalid-de Bakker, Christina Knellwolf, Christoph Knoblauch, Henrik Köhler, Rebekka Koller, Claudia Krieger, Patrizia Künzler, Rachel Kusche, Frank Serge Lehmann, Andrew Macpherson, Michel H. Maillard, Michael Manz, Maude Martinho, Rémy Meier, Christa Meyenberger, Pamela Meyer, Pierre Michetti, Benjamin Misselwitz, Bernhard Morell, Patrick Mosler, Eleni Moschouri, Christian Mottet, Christoph Müller, Beat Müllhaupt, Leilla Musso, Michaela Neagu, Cristina Nichita, Jan Niess, Andreas Nydegger, Nicole Obialo, Cassandra Oropesa, Ulrich Peter, Daniel Peternac, Laetitia Marie Petit, Valérie Pittet, Daniel Pohl, Marc Porzner, Claudia Preissler, Nadia Raschle, Ronald Rentsch, Sophie Restellini, Jean-Pierre Richterich, Sandra Riedmüller, Branislav Risti, Marc Alain Ritz, Gerhard Rogler, Nina Röhrich, Jean-Benoît Rossel, René Roth, Vanessa Rueger, Markus Sagmeister, Gaby Saner, Riad Sarraj, Bernhard Sauter, Mikael Sawatzki, Michael Scharl, Sylvie Scharl, Martin Schelling, Susanne Schibli, Hugo Schlauri, Dominique Schluckebier, Daniela Schmid, Sybille Schmid, Jean-François Schnegg, Alain Schoepfer, Philipp Schreiner, Frank Seibold, Mariam Seirafi, Gian-Marco Semadeni, Arne Senning, Christiane Sokollik, Joachim Sommer, Johannes Spalinger, Holger Spangenberger, Philippe Stadler, Peter Staub, Dominic Staudenmann, Volker Stenz, Michael Steuerwald, Alex Straumann, Andreas Stulz, Michael Sulz, Michela Tempia-Caliera, Joël Thorens, Kaspar Truninger, Radu Tutuian, Patrick Urfer, Stephan Vavricka, Francesco Viani, Fabrizion Vinzens, Jürg Vögtlin, Roland Von Känel, Dominique Vouillamoz, Rachel Vulliamy, Marianne Vullièmoz, Paul Wiesel, Reiner Wiest, Stefanie Wöhrle, Bahtiyar Yilmaz, Samuel Zamora, Silvan Zander, Jonas Zeitz and Dorothee Zimmermann in Therapeutic Advances in Gastroenterology

Published
2021
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36. Fatigue in inflammatory bowel disease and its impact on daily activities

Author

Schreiner, Philipp, Rossel, Jean-Benoît, Biedermann, Luc, Valko, Philipp O, Baumann, Christian R, Greuter, Thomas, Scharl, Michael, Vavricka, Stephan R, Pittet, Valérie, Juillerat, Pascal, Rogler, Gerhard, Von Känel, Roland, and Misselwitz, Benjamin

Subjects
610 Medicine & health, digestive system diseases
Abstract

BACKGROUND Fatigue is a common symptom of chronic inflammation, including inflammatory bowel disease (IBD), resulting in significant impairment in quality of life. AIMS To identify the prevalence of fatigue in a large IBD cohort compared to the general population, address risk factors, and evaluate its impact on daily life. METHODS We evaluated 1208 IBD patients from the Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS) and 414 healthy controls. Significant fatigue was defined as a visual analogue scale (VAS-F, range 0-10) score ≥ 4. Secondary endpoints were severity of fatigue and its impact on daily activities with the Fatigue Severity Scale (FSS), with a score ≥ 4 indicative of fatigue. Demographic, IBD-related and psychiatric symptoms were assessed with a multivariate analysis of variance (MANOVA) model optimised for prediction of VAS-F (primary outcome) and FSS scores. RESULTS Overall, 672 IBD patients (55.6%) reported significant fatigue compared to 145 (35%) controls (OR 2.71; 95% CI 2.08-3.54; P

Published
2021
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37. Effects of anti-TNF therapy and immunomodulators on anxiety and depressive symptoms in patients with inflammatory bowel disease: a 5-year analysis

Author

Siebenhüner, Alexander R; https://orcid.org/0000-0002-5404-2383, Rossel, Jean-Benoît, Schreiner, Philipp, Butter, Matthias, Greuter, Thomas, Krupka, Niklas, Jordi, Sebastian B U, Biedermann, Luc; https://orcid.org/0000-0003-0824-4125, Rogler, Gerhard, Misselwitz, Benjamin, von Känel, Roland, Siebenhüner, Alexander R; https://orcid.org/0000-0002-5404-2383, Rossel, Jean-Benoît, Schreiner, Philipp, Butter, Matthias, Greuter, Thomas, Krupka, Niklas, Jordi, Sebastian B U, Biedermann, Luc; https://orcid.org/0000-0003-0824-4125, Rogler, Gerhard, Misselwitz, Benjamin, and von Känel, Roland

Abstract

Background and aims Anxiety and depression are prevalent in patients with inflammatory bowel diseases (IBD), especially during IBD flares. IBD therapies can profoundly affect the mood of patients with IBD. We aimed to determine the long-term impact of anti-tumor necrosis factor (anti-TNF) and immunomodulators (IM) on anxiety and depressive symptoms in IBD patients. Methods We compared three treatment groups with IM only (group A), anti-TNF ± IM (group B) and no such therapy (group C). Patients completed the hospital anxiety and depression scale (HADS) at 1 year, 3 years, and 5 years after start of treatment. Results In total, 581 patients with IBD (42.9% Crohn's disease, 57.1% ulcerative colitis/IBD unclassified) participated in this study. Effects of treatment were analyzed in a mixed effects model, with and without correction for confounders. Compared with group C, group B showed a significant treatment-related improvement in both anxiety and depressive symptoms within the first 2.5 years and also thereafter. Group A showed a significant long-term improvement of anxiety and both short-term and long-term improvement in depressive symptoms. The significance of these results was maintained after correction for confounders, including corticosteroid treatment. Additionally, both groups A and B showed a significant decrease in disease activity in the first 2.5 years after start of treatment and also thereafter. Anti-TNF and IM treatment were associated with a similarly significant decrease in anxiety and depressive symptoms over an observation period of up to 5 years. Conclusion Besides a clear benefit for disease activity, anti-TNF and IM apparently improve the mood of patients with IBD.

Published
2021

38. A comparison of statistical methods for allocating disease costs in the presence of interactions.

Author

Rossel, Jean‐Benoît, Rousson, Valentin, Eggli, Yves, and Rossel, Jean-Benoît

Subjects
*ECONOMIC aspects of diseases, *COST allocation, *NON-communicable diseases, *PROBLEM solving, *HOSPITAL patients, *COST estimates
Abstract

We consider the non-trivial problem of estimating a health cost repartition among diseases from patients' hospital stays' global costs in the presence of multimorbidity, that is, when the patients may suffer from more than one disease. The problem is even harder in the presence of interactions among the disease costs, that is, when the costs of having, for example, two diseases simultaneously do not match the sum of the basic costs of having each disease alone, generating an extra cost which might be either positive or negative. In such a situation, there might be no "true solution" and the choice of the method to be used to solve the problem will depend on how one wishes to allocate the extra costs among the diseases. In this article, we study mathematically how different methods proceed in this regard, namely ordinary least squares (OLS), generalized linear models (GLM), and an iterative proportional repartition (IPR) algorithm, in a simple case with only two diseases. It turned out that only IPR allowed to retrieve the total costs and the unambiguous solution that one would have in a setting without interaction, that is, when no extra cost has to be allocated, while OLS and GLM may produce some negative health costs. Also, contrary to OLS, IPR is taking into account the basic costs of the diseases for the allocation of the extra cost. We conclude that IPR seems to be the most natural method to solve the problem, at least among those considered. [ABSTRACT FROM AUTHOR]

Published
2021
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39. Sa1280 HISTOLOGICAL PHENOTYPING IN EOSINOPHILIC ESOPHAGITIS: LOCALIZED PROXIMAL DISEASE IS INFREQUENT, BUT ASSOCIATED WITH LESS SEVERE DISEASE AND BETTER DISEASE OUTCOME

Author

Heil, Alexis, Kuehlewindt, Tobias, Godat, Anne, Simon, Hans-Uwe, Simon, Dagmar, Schreiner, Philipp, Saner, Catherine, Vavricka, Stephan R., Biedermann, Luc, Safroneeva, Ekaterina, Rossel, Jean-Benoit, Limacher, Andreas, Straumann, Alex, Schoepfer, Alain M., and Greuter, Thomas

Published
2023
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40. Effects of anti-TNF therapy and immunomodulators on anxiety and depressive symptoms in patients with inflammatory bowel disease: a 5-year analysis

Author

Siebenhüner, Alexander R., primary, Rossel, Jean-Benoît, additional, Schreiner, Philipp, additional, Butter, Matthias, additional, Greuter, Thomas, additional, Krupka, Niklas, additional, Jordi, Sebastian B. U., additional, Biedermann, Luc, additional, Rogler, Gerhard, additional, Misselwitz, Benjamin, additional, von Känel, Roland, additional, Abdelrahman, Karim, additional, Ademi, Gentiana, additional, Aepli, Patrick, additional, Thomas, Amman, additional, Anderegg, Claudia, additional, Antonino, Anca-Teodora, additional, Archanioti, Eva, additional, Arrigoni, Eviano, additional, Aslan, Nurullah, additional, Bakker de Jong, Diana, additional, Balsiger, Bruno, additional, Barry, Mamadou-Pathé, additional, Bastürk, Polat, additional, Bauerfeind, Peter, additional, Becocci, Andrea, additional, Bengoa, José M., additional, Binek, Janek, additional, Blattmann, Mirjam, additional, Boehm, Stephan, additional, Boldanova, Tujana, additional, Borovicka, Jan, additional, Braegger, Christian P., additional, Brand, Stephan, additional, Bravo, Francisco, additional, Brügger, Lukas, additional, Brunner, Simon, additional, Bühr, Patrick, additional, Burk, Sabine, additional, Burri, Emanuel, additional, Buyse, Sophie, additional, Cao, Dahlia-Thao, additional, Carstens, Ove, additional, Criblez, Dominique H., additional, D’Angelo, Fabrizia, additional, Saussure, Philippe de, additional, Degen, Lukas, additional, Delarive, Joakim, additional, Doerig, Christopher, additional, Dora, Barbara, additional, Drerup, Susan, additional, Ducrey, Carole, additional, El-Wafa, Ali, additional, Engelmann, Matthias, additional, Erdmann-Voisin, Aude, additional, Felley, Christian, additional, Fliegner, Markus, additional, Fraga, Montserrat, additional, Franc, Yannick, additional, Frei, Pascal, additional, Frei, Remus, additional, Fried, Michael, additional, Froehlich, Florian, additional, Ivano Furlano, Raoul, additional, Garzoni, Luca, additional, Geyer, Martin, additional, Girardin, Marc, additional, Golay, Delphine, additional, Good, Ignaz, additional, Graf Bigler, Ulrike, additional, Godat, Sébastien, additional, Gysi, Beat, additional, Haarer, Johannes, additional, Halama, Marcel, additional, Haldemann, Janine, additional, Heer, Pius, additional, Heimgartner, Benjamin, additional, Helbling, Beat, additional, Hengstler, Peter, additional, Herzog, Denise, additional, Hess, Cyrill, additional, Hessler, Roxane, additional, Heyland, Klaas, additional, Hinterleitner, Thomas, additional, Hirschi, Claudia, additional, Hruz, Petr, additional, Juillerat, Pascal, additional, Kapoglou, Ioannis, additional, Kayser, Stephan, additional, Keller, Céline, additional, Khalid-de Bakker, Carolina, additional, Knellwolf, Christina, additional, Knoblauch, Christoph, additional, Köhler, Henrik, additional, Koller, Rebekka, additional, Krieger, Claudia, additional, Künzler, Patrizia, additional, Kusche, Rachel, additional, Serge Lehmann, Frank, additional, Macpherson, Andrew, additional, Maillard, Michel H., additional, Manz, Michael, additional, Martinho, Maude, additional, Meier, Rémy, additional, Meyenberger, Christa, additional, Meyer, Pamela, additional, Michetti, Pierre, additional, Morell, Bernhard, additional, Mosler, Patrick, additional, Moschouri, Eleni, additional, Mottet, Christian, additional, Müller, Christoph, additional, Müllhaupt, Beat, additional, Musso, Leilla, additional, Neagu, Michaela, additional, Nichita, Cristina, additional, Niess, Jan, additional, Nydegger, Andreas, additional, Obialo, Nicole, additional, Oropesa, Cassandra, additional, Peter, Ulrich, additional, Peternac, Daniel, additional, Marie Petit, Laetitia, additional, Pittet, Valérie, additional, Pohl, Daniel, additional, Porzner, Marc, additional, Preissler, Claudia, additional, Raschle, Nadia, additional, Rentsch, Ronald, additional, Restellini, Sophie, additional, Richterich, Jean-Pierre, additional, Riedmüller, Sandra, additional, Risti, Branislav, additional, Alain Ritz, Marc, additional, Röhrich, Nina, additional, Roth, René, additional, Rueger, Vanessa, additional, Sagmeister, Markus, additional, Saner, Gaby, additional, Sarraj, Riad, additional, Sauter, Bernhard, additional, Sawatzki, Mikael, additional, Scharl, Michael, additional, Scharl, Sylvie, additional, Schelling, Martin, additional, Schibli, Susanne, additional, Schlauri, Hugo, additional, Schluckebier, Dominique, additional, Schmid, Daniela, additional, Schmid, Sybille, additional, Schnegg, Jean-François, additional, Schoepfer, Alain, additional, Seibold, Frank, additional, Seirafi, Mariam, additional, Semadeni, Gian-Marco, additional, Senning, Arne, additional, Sokollik, Christiane, additional, Sommer, Joachim, additional, Spalinger, Johannes, additional, Spangenberger, Holger, additional, Stadler, Philippe, additional, Staub, Peter, additional, Staudenmann, Dominic, additional, Stenz, Volker, additional, Steuerwald, Michael, additional, Straumann, Alex, additional, Stulz, Andreas, additional, Sulz, Michael, additional, Tempia-Caliera, Michela, additional, Thorens, Joël, additional, Truninger, Kaspar, additional, Tutuian, Radu, additional, Urfer, Patrick, additional, Vavricka, Stephan, additional, Viani, Francesco, additional, Vinzens, Fabrizion, additional, Vögtlin, Jürg, additional, Von Känel, Roland, additional, Vouillamoz, Dominique, additional, Vulliamy, Rachel, additional, Vullièmoz, Marianne, additional, Wiesel, Paul, additional, Wiest, Reiner, additional, Wöhrle, Stefanie, additional, Yilmaz, Bahtiyar, additional, Zamora, Samuel, additional, Zander, Silvan, additional, Zeitz, Jonas, additional, and Zimmermann, Dorothee, additional

Published
2021
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42. Vegetarian or gluten-free diets in patients with inflammatory bowel disease are associated with lower psychological well-being and a different gut microbiota, but no beneficial effects on the course of the disease

Author

Schreiner, Philipp, Yilmaz, Bahtiyar, Rossel, Jean-Benoît, Franc, Yannick, Misselwitz, Benjamin, Scharl, Michael, Zeitz, Jonas, Frei, Pascal, Greuter, Thomas, Vavricka, Stephan R, Pittet, Valérie, Siebenhüner, Alexander, Juillerat, Pascal, von Känel, Roland, Macpherson, Andrew J, Rogler, Gerhard, Biedermann, Luc, Swiss IBD Cohort Study Group, University of Zurich, and Schreiner, Philipp

Subjects
10057 Klinik für Konsiliarpsychiatrie und Psychosomatik, 10219 Clinic for Gastroenterology and Hepatology, 10032 Clinic for Oncology and Hematology, 610 Medicine & health, 2730 Oncology, 2715 Gastroenterology
Published
2019

43. Differences in Outcomes Reported by Patients With Inflammatory Bowel Diseases vs Their Health Care Professionals

Author

Pittet, Valérie E.H., primary, Maillard, Michel H., additional, Simonson, Thomas, additional, Fournier, Nicolas, additional, Rogler, Gerhard, additional, Michetti, Pierre, additional, Anderegg, Claudia, additional, Bauerfeind, Peter, additional, Beglinger, Christoph, additional, Begré, Stefan, additional, Belli, Dominique, additional, Bengoa, José M., additional, Biedermann, Luc, additional, Bigler, Beat, additional, Binek, Janek, additional, Blattmann, Mirjam, additional, Boehm, Stephan, additional, Borovicka, Jan, additional, Braegger, Christian P., additional, Brunner, Nora, additional, Bühr, Patrick, additional, Burnand, Bernard, additional, Burri, Emanuel, additional, Buyse, Sophie, additional, Cremer, Matthias, additional, Criblez, Dominique H., additional, de Saussure, Philippe, additional, Degen, Lukas, additional, Delarive, Joakim, additional, Doerig, Christopher, additional, Dora, Barbara, additional, Dorta, Gian, additional, Egger, Mara, additional, Ehmann, Tobias, additional, El-Wafa, Ali, additional, Engelmann, Matthias, additional, Ezri, Jessica, additional, Felley, Christian, additional, Fliegner, Markus, additional, Fraga, Montserrat, additional, Frei, Pascal, additional, Frei, Remus, additional, Fried, Michael, additional, Froehlich, Florian, additional, Funk, Christian, additional, Furlano, Raoul Ivano, additional, Gallot-Lavallée, Suzanne, additional, Geyer, Martin, additional, Girardin, Marc, additional, Golay, Delphine, additional, Grandinetti, Tanja, additional, Gysi, Beat, additional, Haack, Horst, additional, Haarer, Johannes, additional, Helbling, Beat, additional, Hengstler, Peter, additional, Herzog, Denise, additional, Hess, Cyrill, additional, Heyland, Klaas, additional, Hinterleitner, Thomas, additional, Hiroz, Philippe, additional, Hirschi, Claudia, additional, Hruz, Petr, additional, Iwata, Rika, additional, Jost, Res, additional, Juillerat, Pascal, additional, Keller, Céline, additional, Knellwolf, Christina, additional, Knoblauch, Christoph, additional, Köhler, Henrik, additional, Koller, Rebekka, additional, Krieger-Grübel, Claudia, additional, Kullak-Ublick, Gerd, additional, Künzler, Patrizia, additional, Landolt, Markus, additional, Lange, Rupprecht, additional, Lehmann, Frank Serge, additional, Macpherson, Andrew, additional, Maerten, Philippe, additional, Manser, Christine, additional, Manz, Michael, additional, Marbet, Urs, additional, Marx, George, additional, Matter, Christoph, additional, Meier, Rémy, additional, Mendanova, Martina, additional, Misselwitz, Benjamin, additional, Morell, Bernhard, additional, Mosler, Patrick, additional, Mottet, Christian, additional, Müller, Christoph, additional, Müller, Pascal, additional, Müllhaupt, Beat, additional, Münger-Beyeler, Claudia, additional, Musso, Leilla, additional, Nagy, Andreas, additional, Neagu, Michaela, additional, Nichita, Cristina, additional, Niess, Jan, additional, Nydegger, Andreas, additional, Obialo, Nicole, additional, Oneta, Carl, additional, Oropesa, Cassandra, additional, Peter, Ueli, additional, Peternac, Daniel, additional, Petit, Laetitia Marie, additional, Piccoli-Gfeller, Franziska, additional, Pilz, Julia Beatrice, additional, Pittet, Valérie, additional, Raschle, Nadia, additional, Rentsch, Ronald, additional, Restellini, Sophie, additional, Richterich, Jean-Pierre, additional, Rihs, Sylvia, additional, Ritz, Marc Alain, additional, Roduit, Jocelyn, additional, Rogler, Daniela, additional, Rossel, Jean-Benoît, additional, Rueger, Vanessa, additional, Saner, Gaby, additional, Sauter, Bernhard, additional, Sawatzki, Mikael, additional, Schäppi, Michela, additional, Scharl, Michael, additional, Scharl, Sylvie, additional, Schelling, Martin, additional, Schibli, Susanne, additional, Schlauri, Hugo, additional, Uebelhart, Sybille Schmid, additional, Schnegg, Jean-François, additional, Schoepfer, Alain, additional, Seibold, Frank, additional, Seirafi, Mariam, additional, Semadeni, Gian-Marco, additional, Semela, David, additional, Senning, Arne, additional, Sidler, Marc, additional, Sokollik, Christiane, additional, Spalinger, Johannes, additional, Spangenberger, Holger, additional, Stadler, Philippe, additional, Steuerwald, Michael, additional, Straumann, Alex, additional, Straumann-Funk, Bigna, additional, Sulz, Michael, additional, Suter, Alexandra, additional, Thorens, Joël, additional, Tiedemann, Sarah, additional, Tutuian, Radu, additional, Vavricka, Stephan, additional, Viani, Francesco, additional, Vögtlin, Jürg, additional, Von Känel, Roland, additional, Vonlaufen, Alain, additional, Vouillamoz, Dominique, additional, Vulliamy, Rachel, additional, Wermuth, Jürg, additional, Werner, Helene, additional, Wiesel, Paul, additional, Wiest, Reiner, additional, Wylie, Tina, additional, Zeitz, Jonas, additional, and Zimmermann, Dorothee, additional

Published
2019
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44. Uveitis manifestations in patients of the Swiss Inflammatory Bowel Disease Cohort Study

Author

Biedermann, Luc, Renz, Laura, Fournier, Nicolas, Rossel, Jean-Benoît, Butter, Matthias, Bluemel, Sena, Vavricka, Stephan R, Rogler, Gerhard, Scharl, Michael; https://orcid.org/0000-0002-6729-1469, Biedermann, Luc, Renz, Laura, Fournier, Nicolas, Rossel, Jean-Benoît, Butter, Matthias, Bluemel, Sena, Vavricka, Stephan R, Rogler, Gerhard, and Scharl, Michael; https://orcid.org/0000-0002-6729-1469

Abstract

Background The knowledge about risk factors for the onset of uveitis manifestations in patients with inflammatory bowel disease (IBD) is still limited. Here, we aimed to provide an overview of the clinical factors associated with the onset of uveitis in the Swiss IBD Cohort Study (SIBDCS). Methods We included epidemiological and clinical data from 1840 patients with Crohn's disease (CD) and 1426 patients with ulcerative colitis (UC) followed up in the SIBDCS between 2006 and 2018. Associations between disease characteristics and uveitis were assessed in univariate and multivariate analyses. Results Overall, we identified 285 patients with uveitis. Uveitis was more frequent in patients with CD (11.1%; 205 of 1635) than UC (5.6%; 80 of 1346; odds ratio 2.11, p < 0.001). The occurrence of uveitis manifestations in patients with UC and CD was significantly associated with the onset of other extraintestinal manifestations, also in multivariate analyses. The onset of uveitis was associated with the hallmark features of severe disease in both CD and UC, including a higher clinical disease activity index and the use of immunomodulators or calcineurin inhibitors. In CD, uveitis was more frequent in females and showed a positive correlation with a positive family history of IBD. Conclusions Our data demonstrate that uveitis in IBD occurs more often in CD as well as in women and is associated with a more severe disease course. This might guide physicians' awareness in at-risk patients to the presence of uveitis extraintestinal manifestations and help to improve patient care.

Published
2019

45. The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation

Author

Tcymbarevich, Irina V, Eloranta, Jyrki J, Rossel, Jean-Benoît, Obialo, Nicole, Spalinger, Marianne, Cosin-Roger, Jesus, Lang, Silvia, Kullak-Ublick, Gerd A, Wagner, Carsten A, Scharl, Michael, Seuwen, Klaus, Ruiz, Pedro A, Rogler, Gerhard, de Vallière, Cheryl, Misselwitz, Benjamin; https://orcid.org/0000-0002-8719-5175, Swiss IBD Cohort Study Group, Tcymbarevich, Irina V, Eloranta, Jyrki J, Rossel, Jean-Benoît, Obialo, Nicole, Spalinger, Marianne, Cosin-Roger, Jesus, Lang, Silvia, Kullak-Ublick, Gerd A, Wagner, Carsten A, Scharl, Michael, Seuwen, Klaus, Ruiz, Pedro A, Rogler, Gerhard, de Vallière, Cheryl, Misselwitz, Benjamin; https://orcid.org/0000-0002-8719-5175, and Swiss IBD Cohort Study Group

Abstract

BACKGROUND Tissue inflammation in inflammatory bowel diseases (IBD) is associated with a decrease in local pH. The gene encoding G-protein-coupled receptor 65 (GPR65) has recently been reported to be a genetic risk factor for IBD. In response to extracellular acidification, proton activation of GPR65 stimulates cAMP and Rho signalling pathways. We aimed to analyse the clinical and functional relevance of the GPR65 associated single nucleotide polymorphism (SNP) rs8005161. METHODS 1138 individuals from a mixed cohort of IBD patients and healthy volunteers were genotyped for SNPs associated with GPR65 (rs8005161, rs3742704) and galactosylceramidase (rs1805078) by Taqman SNP assays. 2300 patients from the Swiss IBD Cohort Study (SIBDC) were genotyped for rs8005161 by mass spectrometry based SNP genotyping. IBD patients from the SIBDC carrying rs8005161 TT, CT, CC and non-IBD controls (CC) were recruited for functional studies. Human CD14+ cells were isolated from blood samples and subjected to an extracellular acidic pH shift, cAMP accumulation and RhoA activation were measured. RESULTS In our mixed cohort, but not in SIBDC patients, the minor variant rs8005161 was significantly associated with UC. In SIBDC patients, we observed a consistent trend in increased disease severity in patients carrying the rs8005161-TT and rs8005161-CT alleles. No significant differences were observed in the pH associated activation of cAMP production between IBD (TT, CT, WT/CC) and non-IBD (WT/CC) genotype carriers upon an acidic extracellular pH shift. However, we observed significantly impaired RhoA activation after an extracellular acidic pH shift in IBD patients, irrespective of the rs8005161 allele. CONCLUSIONS The T allele of rs8005161 might confer a more severe disease course in IBD patients. Human monocytes from IBD patients showed impaired pH associated RhoA activation upon an acidic pH shift.

Published
2019

46. Cohort Profile: The Swiss Eosinophilic Esophagitis Cohort Study (SEECS)

Author

Safroneeva, Ekaterina, Saner, Catherine, Rossel, Jean-Benoît, Golay, Delphine, Pittet, Valérie, Godat, Sébastien, Diem, Stefan, Aepli, Patrick, Sawatzki, Mikael, Borovicka, Jan, Burgmann, Konstantin, Juillerat, Pascal, Netzer, Peter, Sendensky, Alexander, Hruz, Petr, Girardin, Marc, Biedermann, Luc, Greuter, Thomas, Vavricka, Stephan, Michetti, Pierre, Mueller, Christoph, Straumann, Alex, Schoepfer, Alain M, Swiss EoE Cohort Study Group, and University of Zurich

Subjects
10219 Clinic for Gastroenterology and Hepatology, 570 Life sciences, biology, 610 Medicine & health, 360 Social problems & social services
Abstract

Background and Aims The prospective, observational Swiss Eosinophilic Esophagitis Cohort Study (SEECS) was set up in 2015 with the following goals in mind: (1) to provide up-to-date epidemiologic data; (2) to assess the appropriateness of care; (3) to evaluate the psychosocial impact; and (4) to foster translational research projects. Data capture relies on validated instruments to assess disease activity and focuses on epidemiologic variables and biosamples (esophageal biopsies and blood specimens). An annual inclusion of 70 new patients with eosinophilic esophagitis (EoE) or proton pump inhibitor-responsive esophageal eosinophilia (PPI-REE) is intended. We herein describe the SEECS cohort profile. Methods The SEECS includes adult patients (age ≥18 years) with EoE or PPI-REE diagnosed according to published criteria. After inclusion, the patients are typically seen once a year for a clinical and endoscopic/histologic follow-up examination. Data are captured using validated questionnaires. Biosamples from patients with gastroesophageal reflux disease (GERD) and controls with a healthy esophagus are collected as well. Results From January 2016 to July 2017, a total of 111 patients with EoE and 10 patients with PPI-REE were recruited. In addition, esophageal biopsies and blood samples from 11 patients with GERD and 20 controls with a healthy esophagus were collected. The mean age of the patients with EoE and those with PPI-REE was 39.6 ± 12.9 and 44.6 ± 15.6 years, respectively. A male predominance was found among both the patients with EoE (77.5%) and those with PPI-REE (70%). Concomitant allergic disorders were found in 79.3% of the patients with EoE and 90% of the patients with PPI-REE. At inclusion, the EoE patients were treated with the following therapeutic regimens: no therapy (0.9%), PPI (36%), swallowed topical corticosteroids (82.9%), elimination diets (15.3%), and esophageal dilation (19.8%). Conclusions The SEECS is the first national cohort study of patients with EoE or PPI-REE. The SEECS will provide up-to-date epidemiologic data and foster translational research projects.

Published
2018
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47. Widely differing screening and treatment practice for osteoporosis in patients with inflammatory bowel diseases in the Swiss IBD cohort study

Author

Schüle, Solvey, Rossel, Jean-Benoît, Frey, Diana, Biedermann, Luc, Scharl, Michael, Zeitz, Jonas, Freitas-Queiroz, Natália, Kuntzen, Thomas, Greuter, Thomas, Vavricka, Stephan R, Rogler, Gerhard, Misselwitz, Benjamin, Swiss IBD Cohort Study Group, University of Zurich, and Misselwitz, Benjamin

Subjects
10219 Clinic for Gastroenterology and Hepatology, 10051 Rheumatology Clinic and Institute of Physical Medicine, 610 Medicine & health, 2700 General Medicine
Published
2017

49. Uveitis manifestations in patients of the Swiss Inflammatory Bowel Disease Cohort Study

Author

Biedermann, Luc, primary, Renz, Laura, additional, Fournier, Nicolas, additional, Rossel, Jean-Benoît, additional, Butter, Matthias, additional, Bluemel, Sena, additional, Vavricka, Stephan R., additional, Rogler, Gerhard, additional, Scharl, Michael, additional, Anderegg, Claudia, additional, Bauerfeind, Peter, additional, Beglinger, Christoph, additional, Begré, Stefan, additional, Belli, Dominique, additional, Bengoa, José M., additional, Biedermann, Luc, additional, Bigler, Beat, additional, Binek, Janek, additional, Blattmann, Mirjam, additional, Boehm, Stephan, additional, Borovicka, Jan, additional, Braegger, Christian P., additional, Brunner, Nora, additional, Bühr, Patrick, additional, Burnand, Bernard, additional, Burri, Emanuel, additional, Buyse, Sophie, additional, Cremer, Matthias, additional, Criblez, Dominique H., additional, Saussure, Philippe de, additional, Degen, Lukas, additional, Delarive, Joakim, additional, Doerig, Christopher, additional, Dora, Barbara, additional, Dorta, Gian, additional, Egger, Mara, additional, Ehmann, Tobias, additional, El-Wafa, Ali, additional, Engelmann, Matthias, additional, Ezri, Jessica, additional, Felley, Christian, additional, Fliegner, Markus, additional, Fraga, Montserrat, additional, Frei, Pascal, additional, Frei, Remus, additional, Fried, Michael, additional, Froehlich, Florian, additional, Funk, Christian, additional, Ivano Furlano, Raoul, additional, Gallot-Lavallée, Suzanne, additional, Geyer, Martin, additional, Girardin, Marc, additional, Golay, Delphine, additional, Grandinetti, Tanja, additional, Gysi, Beat, additional, Haack, Horst, additional, Haarer, Johannes, additional, Helbling, Beat, additional, Hengstler, Peter, additional, Herzog, Denise, additional, Hess, Cyrill, additional, Heyland, Klaas, additional, Hinterleitner, Thomas, additional, Hiroz, Philippe, additional, Hirschi, Claudia, additional, Hruz, Petr, additional, Iwata, Rika, additional, Jost, Res, additional, Juillerat, Pascal, additional, Kessler Brondolo, Vera, additional, Knellwolf, Christina, additional, Knoblauch, Christoph, additional, Köhler, Henrik, additional, Koller, Rebekka, additional, Krieger-Grübel, Claudia, additional, Kullak-Ublick, Gerd, additional, Künzler, Patrizia, additional, Landolt, Markus, additional, Lange, Rupprecht, additional, Serge Lehmann, Frank, additional, Macpherson, Andrew, additional, Maerten, Philippe, additional, Maillard, Michel H., additional, Manser, Christine, additional, Manz, Michael, additional, Marbet, Urs, additional, Marx, George, additional, Matter, Christoph, additional, McLin, Valérie, additional, Meier, Rémy, additional, Mendanova, Martina, additional, Meyenberger, Christa, additional, Michetti, Pierre, additional, Misselwitz, Benjamin, additional, Moradpour, Darius, additional, Morell, Bernhard, additional, Mosler, Patrick, additional, Mottet, Christian, additional, Müller, Christoph, additional, Müller, Pascal, additional, Müllhaupt, Beat, additional, Münger-Beyeler, Claudia, additional, Musso, Leilla, additional, Nagy, Andreas, additional, Neagu, Michaela, additional, Nichita, Cristina, additional, Niess, Jan, additional, Noël, Natacha, additional, Nydegger, Andreas, additional, Obialo, Nicole, additional, Oneta, Carl, additional, Oropesa, Cassandra, additional, Peter, Ueli, additional, Peternac, Daniel, additional, Marie Petit, Laetitia, additional, Piccoli-Gfeller, Franziska, additional, Beatrice Pilz, Julia, additional, Pittet, Valérie, additional, Raschle, Nadia, additional, Rentsch, Ronald, additional, Restellini, Sophie, additional, Richterich, Jean-Pierre, additional, Rihs, Sylvia, additional, Alain Ritz, Marc, additional, Roduit, Jocelyn, additional, Rogler, Daniela, additional, Sagmeister, Markus, additional, Saner, Gaby, additional, Sauter, Bernhard, additional, Sawatzki, Mikael, additional, Schäppi, Michela, additional, Schelling, Martin, additional, Schibli, Susanne, additional, Schlauri, Hugo, additional, Schmid Uebelhart, Sybille, additional, Schnegg, Jean-François, additional, Schoepfer, Alain, additional, Seibold, Frank, additional, Seirafi, Mariam, additional, Semadeni, Gian-Marco, additional, Semela, David, additional, Senning, Arne, additional, Sidler, Marc, additional, Sokollik, Christiane, additional, Spalinger, Johannes, additional, Spangenberger, Holger, additional, Stadler, Philippe, additional, Steuerwald, Michael, additional, Straumann, Alex, additional, Straumann-Funk, Bigna, additional, Sulz, Michael, additional, Thorens, Joël, additional, Tiedemann, Sarah, additional, Tutuian, Radu, additional, Vavricka, Stephan, additional, Viani, Francesco, additional, Vögtlin, Jürg, additional, Von Känel, Roland, additional, Vonlaufen, Alain, additional, Vouillamoz, Dominique, additional, Vulliamy, Rachel, additional, Wermuth, Jürg, additional, Werner, Helene, additional, Wiesel, Paul, additional, Wiest, Reiner, additional, Wylie, Tina, additional, Zeitz, Jonas, additional, and Zimmermann, Dorothee, additional

Published
2019
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