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391 results on '"Rossbach, J."'

1. A Setup to Study Atomic State Population Dynamics and Optical Polarization at CRYRING@ESR

Author

Mohr, K., Sánchez, R., Nörtershäuser, W., Andelkovic, Z., Hannen, V., Hanu, E. -O., Herfurth, F., Heß, R., Horst, M., Imgram, P., König, K., Krantz, C., Lestinsky, M., Litvinov, Yu. A., Menz, E., Müller, P., Palmes, J., Rausch, S., Ratajczyk, T., Renth, L., Rossbach, J., Sidhu, R. S., Sommer, F., Spahn, J., Stallkamp, N., Ueberholz, K., Vorobjev, G., Weinheimer, C., and Zisis, D.

Subjects
Physics - Atomic Physics, Physics - Accelerator Physics
Abstract

We present a recently established setup for laser spectroscopy at CRYRING@ESR at the GSI Helmholtz Centre for Heavy Ion Research. Here, laser spectroscopy can be performed on stored and cooled ion bunches and coasting beams. First spectra of $^{24,25}$Mg$^+$ ions are presented that were recorded by classical Doppler-limited fluorescence spectroscopy as well as $\Lambda$-spectroscopy using counter- and copropagating laser beams that are Doppler-shifted by several nm., Comment: 10 pages, 8 figures, submitted to conference proceedings of "1st Workshop on Polarized Beam and Target-Physics and Applications"

Published
2024

2. New Test of Modulated Electron Capture Decay of Hydrogen-Like $^{142}$Pm Ions: Precision Measurement of Purely Exponential Decay

Author

Ozturk, F. C., Akkus, B., Atanasov, D., Beyer, H., Bosch, F., Boutin, D., Brandau, C., Bühler, P., Cakirli, R. B., Chen, R. J., Chen, W. D., Chen, X. C., Dillmann, I., Dimopoulou, C., Enders, W., Essel, H. G., Faestermann, T., Forstner, O., Gao, B. S., Geissel, H., Gernhäuser, R., Grisenti, R. E., Gumberidze, A., Hagmann, S., Heftrich, T., Heil, M., Herdrich, M. O., Hillenbrand, P. -M., Izumikawa, T., Kienle, P., Klaushofer, C., Kleffner, C., Kozhuharov, C., Knöbel, R. K., Kovalenko, O., Kreim, S., Kühl, T., Lederer-Woods, C., Lestinsky, M., Litvinov, S. A., Litvinov, Yu. A., Liu, Z., Ma, X. W., Maier, L., Mei, B., Miura, H., Mukha, I., Najafi, A., Nagae, D., Nishimura, T., Nociforo, C., Nolden, F., Ohtsubo, T., Oktem, Y., Omika, S., Ozawa, A., Petridis, N., Piotrowski, J., Reifarth, R., Rossbach, J., Sánchez, R., Sanjari, M. S., Scheidenberger, C., Sidhu, R. S., Simon, H., Spillmann, U., Steck, M., Stöhlker, Th., Sun, B. H., Susam, L. A., Suzaki, F., Suzuki, T., Torilov, S. Yu., Trageser, C., Trassinelli, M., Trotsenko, S., Tu, X. L., Walker, P. M., Wang, M., Weber, G., Weick, H., Winckler, N., Winters, D. F. A., Woods, P. J., Yamaguchi, T., Xu, X. D., Yan, X. L., Yang, J. C., Yuan, Y. J., Zhang, Y. H., Zhou, X. H., Collaboration, the FRS-ESR, Collaboration, the ILIMA, Collaboration, the SPARC, and Collaboration, the TBWD

Subjects
Nuclear Experiment
Abstract

An experiment addressing electron capture (EC) decay of hydrogen-like $^{142}$Pm$^{60+}$ ions has been conducted at the experimental storage ring (ESR) at GSI. The decay appears to be purely exponential and no modulations were observed. Decay times for about 9000 individual EC decays have been measured by applying the single-ion decay spectroscopy method. Both visually and automatically analysed data can be described by a single exponential decay with decay constants of 0.0126(7) s$^{-1}$ for automatic analysis and 0.0141(7) s$^{-1}$ for manual analysis. If a modulation superimposed on the exponential decay curve is assumed, the best fit gives a modulation amplitude of merely 0.019(15), which is compatible with zero and by 4.9 standard deviations smaller than in the original observation which had an amplitude of 0.23(4).

Published
2019
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3. Application of Accelerators and Storage Rings

Author

Dohlus, M., Rossbach, J., Bethge, K. H. W., Meijer, J., Amaldi, U., Magrin, G., Lindroos, M., Molloy, S., Rees, G., Seidel, M., Angert, N., Boine-Frankenheim, O., Myers, Stephen, editor, and Schopper, Herwig, editor

Published
2020
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5. Flash II: Perspectives and challenges

Author

Faatz, B., Baboi, N., Ayvazyan, V., Balandin, V., Decking, W., Duesterer, S., Eckoldt, H.-J., Feldhaus, J., Golubeva, N., Honkavaara, K., Koerfer, M., Laarmann, T., Leuschner, A., Lilje, L., Limberg, T., Noelle, D., Obier, F., Petrov, A., Ploenjes, E., Rehlich, K., Schlarb, H., Schmidt, B., Schmitz, M., Schreiber, S., Schulte-Schrepping, H., Spengler, J., Staack, M., Tavella, F., Tiedtke, K., Tischer, M., Treusch, R., Vogt, M., Willner, A., Bahrdt, J., Follath, R., Gensch, M., Holldack, K., Meseck, A., Mitzner, R., Drescher, M., Miltchev, V., Rönsch-Schulenburg, J., and Rossbach, J.

Published
2011
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7. New infrared undulator beamline at FLASH

Author

Gensch, M., Bittner, L., Chesnov, A., Delsim-Hashemi, H., Drescher, M., Faatz, B., Feldhaus, J., Fruehling, U., Geloni, G.A., Gerth, Ch., Grimm, O., Hahn, U., Hesse, M., Kapitzki, S., Kocharyan, V., Kozlov, O., Matyushevsky, E., Morozov, N., Petrov, D., Ploenjes, E., Roehling, M., Rossbach, J., Saldin, E.L., Schmidt, B., Schmueser, P., Schneidmiller, E.A., Syresin, E., Willner, A., and Yurkov, M.V.

Published
2008
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8. First operation of a free-electron laser generating GW power radiation at 32 nm wavelength

Author

Ayvazyan, V., Baboi, N., Bähr, J., Balandin, V., Beutner, B., Brandt, A., Bohnet, I., Bolzmann, A., Brinkmann, R., Brovko, O. I., Carneiro, J. P., Casalbuoni, S., Castellano, M., Castro, P., Catani, L., Chiadroni, E., Choroba, S., Cianchi, A., Delsim-Hashemi, H., Di Pirro, G., Dohlus, M., Düsterer, S., Edwards, H. T., Faatz, B., Fateev, A. A., Feldhaus, J., Flöttmann, K., Frisch, J., Fröhlich, L., Garvey, T., Gensch, U., Golubeva, N., Grabosch, H.-J., Grigoryan, B., Grimm, O., Hahn, U., Han, J. H., Hartrott, M. V., Honkavaara, K., Hüning, M., Ischebeck, R., Jaeschke, E., Jablonka, M., Kammering, R., Katalev, V., Keitel, B., Khodyachykh, S., Kim, Y., Kocharyan, V., Körfer, M., Kollewe, M., Kostin, D., Krämer, D., Krassilnikov, M., Kube, G., Lilje, L., Limberg, T., Lipka, D., Löhl, F., Luong, M., Magne, C., Menzel, J., Michelato, P., Miltchev, V., Minty, M., Möller, W. D., Monaco, L., Müller, W., Nagl, M., Napoly, O., Nicolosi, P., Nölle, D., Nuñez, T., Oppelt, A., Pagani, C., Paparella, R., Petersen, B., Petrosyan, B., Pflüger, J., Piot, P., Plönjes, E., Poletto, L., Proch, D., Pugachov, D., Rehlich, K., Richter, D., Riemann, S., Ross, M., Rossbach, J., Sachwitz, M., Saldin, E. L., Sandner, W., Schlarb, H., Schmidt, B., Schmitz, M., Schmüser, P., Schneider, J. R., Schneidmiller, E. A., Schreiber, H.-J., Schreiber, S., Shabunov, A. V., Sertore, D., Setzer, S., Simrock, S., Sombrowski, E., Staykov, L., Steffen, B., Stephan, F., Stulle, F., Sytchev, K. P., Thom, H., Tiedtke, K., Tischer, M., Treusch, R., Trines, D., Tsakov, I., Vardanyan, A., Wanzenberg, R., Weiland, T., Weise, H., Wendt, M., Will, I., Winter, A., Wittenburg, K., Yurkov, M. V., Zagorodnov, I., Zambolin, P., and Zapfe, K.

Published
2006
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9. New test of modulated electron capture decay of hydrogen-like 142Pm ions: Precision measurement of purely exponential decay

Author

Ozturk, F. C., Akkus, B., Atanasov, D., Beyer, H., Bosch, F., Boutin, D., Brandau, C., Bühler, P., Cakirli, R. B., Chen, R. J., Chen, W. D., Chen, X. C., Dillmann, I., Dimopoulou, C., Enders, W., Essel, H. G., Faestermann, T., Forstner, O., Gao, B. S., Geissel, H., Gernhäuser, R., Grisenti, R. E., Gumberidze, A., Hagmann, S., Heftrich, T., Heil, M., Herdrich, M. O., Hillenbrand, P. -M., Izumikawa, T., Kienle, P., Klaushofer, C., Kleffner, C., Kozhuharov, C., Knöbel, R. K., Kovalenko, O., Kreim, S., Kühl, T., Lederer-Woods, C., Lestinsky, M., Litvinov, S. A., Litvinov, Yu. A., Liu, Z., Ma, X. W., Maier, L., Mei, B., Miura, H., Mukha, I., Najafi, A., Nagae, D., Nishimura, T., Nociforo, C., Nolden, F., Ohtsubo, T., Oktem, Y., Omika, S., Ozawa, A., Petridis, N., Piotrowski, J., Reifarth, R., Rossbach, J., Sánchez, R., Sanjari, M. S., Scheidenberger, C., Sidhu, R. S., Simon, H., Spillmann, U., Steck, M., Stöhlker, Th., Sun, B. H., Susam, L. A., Suzaki, F., Suzuki, T., Torilov, S. Yu., Trageser, C., Trassinelli, M., Trotsenko, S., Tu, X. L., Walker, P. M., Wang, M., Weber, G., Weick, H., Winckler, N., Winters, D. F. A., Woods, P. J., Yamaguchi, T., Xu, X. D., Yan, X. L., Yang, J. C., Yuan, Y. J., Zhang, Y. H., Zhou, X. H., Collaboration, the FRS-ESR, Collaboration, the ILIMA, Collaboration, the SPARC, Collaboration, the TBWD, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut des Nanosciences de Paris (INSP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), FRS-ESR, ILIMA, SPARC, and TBWD

Subjects
Nuclear and High Energy Physics, Electron capture, FOS: Physical sciences, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], nucl-ex, 01 natural sciences, Ion, 0103 physical sciences, Modulation (music), Orbital electron capture, Nuclear Physics - Experiment, ddc:530, Nuclear Experiment (nucl-ex), Exponential decay, 010306 general physics, Spectroscopy, Nuclear Experiment, Physics, 010308 nuclear & particles physics, lcsh:QC1-999, 3. Good health, Exponential function, Two body weak decay, Heavy ion storage ring, Single particle decay spectroscopy, Amplitude, High Energy Physics::Experiment, Atomic physics, Storage ring, lcsh:Physics
Abstract

An experiment addressing electron capture (EC) decay of hydrogen-like Pm60+142 ions has been conducted at the experimental storage ring (ESR) at GSI. The decay appears to be purely exponential and no modulations were observed. Decay times for about 9000 individual EC decays have been measured by applying the single-ion decay spectroscopy method. Both visually and automatically analysed data can be described by a single exponential decay with decay constants of 0.0126(7)s−1 for automatic analysis and 0.0141(7)s−1 for manual analysis. If a modulation superimposed on the exponential decay curve is assumed, the best fit gives a modulation amplitude of merely 0.019(15), which is compatible with zero and by 4.9 standard deviations smaller than in the original observation which had an amplitude of 0.23(4). An experiment addressing electron capture (EC) decay of hydrogen-like $^{142}$Pm$^{60+}$ ions has been conducted at the experimental storage ring (ESR) at GSI. The decay appears to be purely exponential and no modulations were observed. Decay times for about 9000 individual EC decays have been measured by applying the single-ion decay spectroscopy method. Both visually and automatically analysed data can be described by a single exponential decay with decay constants of 0.0126(7) s$^{-1}$ for automatic analysis and 0.0141(7) s$^{-1}$ for manual analysis. If a modulation superimposed on the exponential decay curve is assumed, the best fit gives a modulation amplitude of merely 0.019(15), which is compatible with zero and by 4.9 standard deviations smaller than in the original observation which had an amplitude of 0.23(4).

Published
2019

11. A new powerful source for coherent VUV radiation: Demonstration of exponential growth and saturation at the TTF free-electron laser

Author

Ayvazyan, V., Baboi, N., Bohnet, I., Brinkmann, R., Castellano, M., Castro, P., Catani, L., Choroba, S., Cianchi, A., Dohlus, M., Edwards, H.T., Faatz, B., Fateev, A.A., Feldhaus, J., Flöttmann, K., Gamp, A., Garvey, T., Genz, H., Gerth, Ch., Gretchko, V., Grigoryan, B., Hahn, U., Hessler, C., Honkavaara, K., Hüning, M., Ischebeck, R., Jablonka, M., Kamps, T., Körfer, M., Krassilnikov, M., Krzywinski, J., Liepe, M., Liero, A., Limberg, T., Loos, H., Luong, M., Magne, C., Menzel, J., Michelato, P., Minty, M., Müller, U.-C., Nölle, D., Novokhatski, A., Pagani, C., Peters, F., Pflüger, J., Piot, P., Plucinski, L., Rehlich, K., Reyzl, I., Richter, A., Rossbach, J., Saldin, E.L., Sandner, W., Schlarb, H., Schmidt, G., Schmüser, P., Schneider, J.R., Schneidmiller, E.A., Schreiber, H.-J., Schreiber, S., Sertore, D., Setzer, S., Simrock, S., Sobierajski, R., Sonntag, B., Steeg, B., Stephan, F., Sytchev, K.P., Tiedtke, K., Tonutti, M., Treusch, R., Trines, D., Türke, D., Verzilov, V., Wanzenberg, R., Weiland, T., Weise, H., Wendt, M., Wilhein, T., Will, I., Wittenburg, K., Wolff, S., Yurkov, M.V., and Zapfe, K.

Published
2002
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12. Conference Committees

Author

Minehara, Eisuke J., primary, Awazu, Kunio, additional, Shimoda, Koichi, additional, Awazu, K., additional, Hama, H., additional, Harami, T., additional, Imasaki, K., additional, Kimura, H., additional, Kimura, T., additional, Kuroda, H., additional, Shimoda, K., additional, Tomimasu, T., additional, Tomita, T., additional, Yamada, K., additional, Yamazaki, T., additional, Ben-Zvi, I., additional, Colson, W.B., additional, Couprie, M.-E., additional, Gover, A., additional, Kim, K.-J., additional, Li, Y., additional, Litvinenko, V.N., additional, Minehara, E.J., additional, Neil, G.R., additional, Pellegrini, C., additional, Poole, M.W., additional, Renieri, A., additional, Roberson, C.W., additional, Rossbach, J., additional, Smith, T., additional, van der Meer, A.F.G., additional, Vinokurov, N.A., additional, Walker, R., additional, Hajima, Ryoichi, additional, Kimura, Toyoaki, additional, Bakker, R., additional, Benson, S., additional, Brau, C., additional, Dai, J., additional, Dattoli, G., additional, Faatz, B., additional, Freund, H.P., additional, Galayda, J.N., additional, Ginzburg, N., additional, Glotin, F., additional, Hajima, R., additional, Hiramatsu, S., additional, Kato, R., additional, Krinsky, S., additional, Lee, B.C., additional, Lumpkin, A.H., additional, Nguyen, D., additional, Ohgaki, H., additional, Pflüger, J., additional, Reiche, S., additional, Shimizu, Y., additional, Shinn, M., additional, Shintake, T., additional, Shu, X., additional, and Xie, M., additional

Published
2004
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13. New test of modulated electron capture decay of hydrogen-like Pm ions: Precision measurement of purely exponential decay

Author

Ozturk, F.C., Akkus, B., Atanasov, D., Beyer, H., Bosch, F., Boutin, D., Brandau, C., Bühler, P., Cakirli, R.B., Chen, R.J., Chen, W.D., Chen, X.C., Dillmann, I., Dimopoulou, C., Enders, W., Essel, H.G., Faestermann, T., Forstner, O., Gao, B.S., Geissel, H., Gernhäuser, R., Grisenti, R.E., Gumberidze, A., Hagmann, S., Heftrich, T., Heil, M., Herdrich, M.O., Hillenbrand, P.M., Izumikawa, T., Kienle, P., Klaushofer, C., Kleffner, C., Kozhuharov, C., Knöbel, R.K., Kovalenko, O., Kreim, S., Kühl, T., Lederer-Woods, C., Lestinsky, M., Litvinov, S.A., Litvinov, Yu.A., Liu, Z., Ma, X.W., Maier, L., Mei, B., Miura, H., Mukha, I., Najafi, A., Nagae, D., Nishimura, T., Nociforo, C., Nolden, F., Ohtsubo, T., Oktem, Y., Omika, S., Ozawa, A., Petridis, N., Piotrowski, J., Reifarth, R., Rossbach, J., Sánchez, R., Sanjari, M.S., Scheidenberger, C., Sidhu, R.S., Simon, H., Spillmann, U., Steck, M., Stöhlker, Th., Sun, B.H., Susam, L.A., Suzaki, F., Suzuki, T., Torilov, S.Yu., Trageser, C., Trassinelli, M., Trotsenko, S., Tu, X.L., Walker, P.M., Wang, M., Weber, G., Weick, H., Winckler, N., Winters, D.F.A., Woods, P.J., Yamaguchi, T., Xu, X.D., Yan, X.L., Yang, J.C., Yuan, Y.J., Zhang, Y.H., and Zhou, X.H.

Abstract

An experiment addressing electron capture (EC) decay of hydrogen-like Pm60+142 ions has been conducted at the experimental storage ring (ESR) at GSI. The decay appears to be purely exponential and no modulations were observed. Decay times for about 9000 individual EC decays have been measured by applying the single-ion decay spectroscopy method. Both visually and automatically analysed data can be described by a single exponential decay with decay constants of 0.0126(7)s−1 for automatic analysis and 0.0141(7)s−1 for manual analysis. If a modulation superimposed on the exponential decay curve is assumed, the best fit gives a modulation amplitude of merely 0.019(15), which is compatible with zero and by 4.9 standard deviations smaller than in the original observation which had an amplitude of 0.23(4).

Published
2019

14. Seeding R&D at sFLASH∗

Author

Lechner, Christoph, Ackermann, Sven, Assmann, R. W., Faatz, B., Grattoni, V., Hartl, I., Hartwell, Samuel, Ivanov, R., Mohammad Kazemi, Mehdi, Laarmann, T., Lang, T., Paraskaki, G., Przystawik, A., Zheng, J., Khan, S., Azima, Germany A., Biss, H., Drescher, M., Hillert, W., Miltchev, V., and Rossbach, J.

Abstract

39th International Free-Electron Laser Conference, FEL19, Hamburg, Germany, 26 Aug 2019 - 30 Aug 2019; 230--233 (2019)., Free-electron lasers (FELs) based on the self-amplified spontaneous emission (SASE) principle generate photon pulses with typically poor longitudinal coherence. FEL seeding techniques greatly improve longitudinal coherence by initiating FEL amplification in a controlled way using coherent light pulses. The sFLASH experiment installed at the FEL user facility FLASH at DESY in Hamburg is dedicated to the study of external seeding techniques. In this paper, the layout of the sFLASH seeding experiment is presented and an overview of recent developments is given.

Published
2019

15. First beam measurements at the photo injector test facility at DESY Zeuthen

Author

Bakker, R., primary, Hartrott, M.v., additional, Jaeschke, E., additional, Krämer, D., additional, Carneiro, J.P., additional, Flöttmann, K., additional, Piot, P., additional, Roßbach, J., additional, Schreiber, S., additional, Abrahamyan, K., additional, Bähr, J., additional, Bohnet, I., additional, Djordjadze, V., additional, Gensch, U., additional, Graboschi, H.J., additional, Li, Z., additional, Lipka, D., additional, Oppelt, A., additional, Petrossyan, B., additional, Stephan, F., additional, Michelato, P., additional, Pagani, C., additional, Sertore, D., additional, Miltchev, V., additional, Tsakov, I., additional, Liero, A., additional, Redlin, H., additional, Sandner, W., additional, Schumann, R., additional, Will, I., additional, Cee, R., additional, Krassilnikov, M., additional, Setzer, S., additional, and Weiland, T., additional

Published
2003
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16. RF Commissioning of the Photo Injector Test Facility at DESY Zeuthen

Author

Abrahamyan, K., primary, Bähr, J., additional, Bohnet, I., additional, Choroba, S., additional, Flöttmann, K., additional, Grabosch, H.-J., additional, Hartrott, M.v., additional, Ischebeck, R., additional, Krebs, O., additional, Li, Z., additional, Lipka, D., additional, Oppelt, A., additional, Peplov, V., additional, Petrosyan, B., additional, Pohl, M., additional, Rossbach, J., additional, Simrock, S., additional, Stephan, F., additional, Thon, T., additional, Wenndorff, R., additional, and Winde, M., additional

Published
2003
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18. Study of the statistical properties of the radiation from a VUV SASE FEL operating in the femtosecond regime

Author

Ayvazyan, V., primary, Carneiro, J.-P., additional, Castro, P., additional, Faatz, B., additional, Fateev, A.A., additional, Feldhaus, J., additional, Gerth, Ch., additional, Gretchko, V., additional, Grigoryan, B., additional, Hahn, U., additional, Honkavaara, K., additional, Hüning, M., additional, Ischebeck, R., additional, Jastrow, U., additional, Kammering, R., additional, Menzel, J., additional, Minty, M., additional, Nölle, D., additional, Pflüger, J., additional, Piot, Ph., additional, Plucinski, L., additional, Rehlich, K., additional, Rossbach, J., additional, Saldin, E.L., additional, Schlarb, H., additional, Schneidmiller, E.A., additional, Schreiber, S., additional, Sobierajski, R., additional, Steeg, B., additional, Stulle, F., additional, Sytchev, K.P., additional, Tiedtke, K., additional, Treusch, R., additional, Weise, H., additional, Wendt, M., additional, and Yurkov, M.V., additional

Published
2003
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19. Characterization of the electron source at the photo injector test facility at DESY Zeuthen

Author

Abrahamyan, K, Ackermann, W, Bähr, J, Bohnet, I, Carneiro, J.P, Cee, R, Flöttmann, K, Gensch, U, Grabosch, H.-J, Han, J.H, Hartrott, M.V, Jaeschke, E, Krämer, D, Krasilnikov, M, Lipka, D, Michelato, P, Miltchev, V, Müller, W.F.O, Oppelt, A, Pagani, C, Petrossyan, B, Roßbach, J, Sandner, W, Schreiber, S, Sertore, D, Setzer, S, Staykov, L, Stephan, F, Tsakov, I, Weiland, T, and Will, I

Published
2004
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22. First beam measurements at the photo injector test facility at DESY Zeuthen

Author

Bakker, R., Hartrott, M.v., Jaeschke, E., Krämer, D., Carneiro, J.P., Flöttmann, K., Piot, P., Roßbach, J., Schreiber, S., Abrahamyan, K., Bähr, J., Bohnet, I., Djordjadze, V., Gensch, U., Graboschi, H.J., Li, Z., Lipka, D., Oppelt, A., Petrossyan, B., Stephan, F., Michelato, P., Pagani, C., Sertore, D., Miltchev, V., Tsakov, I., Liero, A., Redlin, H., Sandner, W., Schumann, R., Will, I., Cee, R., Krassilnikov, M., Setzer, S., and Weiland, T.

Published
2003
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23. Study of the statistical properties of the radiation from a VUV SASE FEL operating in the femtosecond regime

Author

Ayvazyan, V, Carneiro, J.-P, Castro, P, Faatz, B, Fateev, A.A, Feldhaus, J, Gerth, Ch, Gretchko, V, Grigoryan, B, Hahn, U, Honkavaara, K, Hüning, M, Ischebeck, R, Jastrow, U, Kammering, R, Menzel, J, Minty, M, Nölle, D, Pflüger, J, Piot, Ph, Plucinski, L, Rehlich, K, Rossbach, J, Saldin, E.L, Schlarb, H, Schneidmiller, E.A, Schreiber, S, Sobierajski, R, Steeg, B, Stulle, F, Sytchev, K.P, Tiedtke, K, Treusch, R, Weise, H, Wendt, M, and Yurkov, M.V

Published
2003
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25. 20-year risks of breast-cancer recurrence after stopping endocrine therapy at 5 years

Author

Pan, H, Gray, R, Braybrooke, J, Davies, C, Taylor, C, Mcgale, P, Peto, R, Pritchard, Ki, Bergh, J, Dowsett, M, Hayes, Df, Albain, K, Anderson, S, Arriagada, R, Barlow, W, Bartlett, J, Bergsten‐nordström, E, Bliss, J, Boccardo, F, Bradley, R, Brain, E, Cameron, D, Clarke, M, Coates, A, Coleman, R, Correa, C, Costantino, J, Cuzick, J, Davidson, N, Dodwell, D, Di Leo, A, Ewertz, M, Forbes, J, Gelber, R, Gnant, M, Goldhirsch, A, Goodwin, P, Hill, C, Ingle, J, Jagsi, R, Janni, W, Loibl, S, Mackinnon, E, Martin, M, Mukai, H, Norton, L, Ohashi, Y, Paik, S, Perez, E, Piccart, M, Pierce, L, Poortmans, P, Raina, V, Ravdin, P, Regan, M, Robertson, J, Rutgers, E, Slamon, D, Sparano, J, Swain, S, Tutt, A, Viale, G, Von Minckwitz, G, Wang, X, Whelan, T, Wilcken, N, Winer, E, Wolmark, N, Wood, W, Zambetti, M, Alberro, Ja, Ballester, B, Deulofeu, P, Fábregas, R, Fraile, M, Gubern, Jm, Janer, J, Moral, A, De Pablo Jl, Peñalva, G, Puig, P, Ramos, M, Rojo, R, Santesteban, P, Serra, C, Solà, M, Solarnau, L, Solsona, J, Veloso, E, Vidal, S, Abe, O, Abe, R, Enomoto, K, Kikuchi, K, Koyama, H, Masuda, H, Nomura, Y, Sakai, K, Sugimachi, K, Toi, M, Tominaga, T, Uchino, J, Yoshida, M, Haybittle, Jl, Leonard, Cf, Calais, G, Garaud, P, Collett, V, Delmestri, A, Sayer, J, Harvey, Vj, Holdaway, Im, Kay, Rg, Mason, Bh, Forbes, Jf, Balic, M, Bartsch, R, Fesl, C, Fitzal, F, Fohler, H, Greil, R, Jakesz, R, Marth, C, Mlineritsch, B, Pfeiler, G, Singer, Cf, Steger, Gg, Stöger, H, Canney, P, Yosef, Hma, Focan, C, Peek, U, Oates, Gd, Powell, J, Durand, M, Mauriac, L, Dolci, S, Larsimont, D, Nogaret, Jm, Philippson, C, Piccart, Mj, Masood, Mb, Parker, D, Price, Jj, Lindsay, Ma, Mackey, J, Hupperets, Psgj, Bates, T, Blamey, Rw, Chetty, U, Ellis, Io, Mallon, E, Morgan, Dal, Patnick, J, Pinder, S, Lohrisch, C, Nichol, A, Bramwell, Vh, Chen, Be, Gelmon, K, Goss, Pe, Levine, Mn, Parulekar, W, Pater, Jl, Shepherd, Le, Tu, D, Berry, D, Broadwater, G, Cirrincione, C, Muss, H, Weiss, Rb, Abu‐zahra, Ht, Portnoj, Sm, Bowden, S, Brookes, C, Dunn, J, Fernando, I, Lee, M, Poole, C, Rea, D, Spooner, D, Barrett‐lee, Pj, Mansel, Re, Monypenny, Ij, Gordon, Nh, Davis, Hl, Sestak, I, Lehingue, Y, Romestaing, P, Dubois, Jb, Delozier, T, Griffon, B, Mace Lesec’h, J, De La Lande, B, Mouret‐fourme, E, Mustacchi, G, Petruzelka, L, Pribylova, O, Owen, Jr, Harbeck, N, Jänicke, F, Meisner, C, Schmitt, M, Thomssen, C, Meier, P, Shan, Y, Shao, Yf, Zhao, Db, Chen, Zm, Howell, A, Swindell, R, Boddington, C, Burrett, Ja, Cutter, D, Duane, F, Evans, V, Gettins, L, Godwin, J, James, S, Kerr, A, Liu, H, Mannu, G, Mchugh, T, Morris, P, Read, S, Wang, Y, Wang, Z, Albano, J, De Oliveira Cf, Gervásio, H, Gordilho, J, Ejlertsen, B, Jensen, Mb, Johansen, H, Mouridsen, H, Palshof, T, Gelman, Rs, Harris, Jr, Henderson, C, Shapiro, Cl, Christiansen, P, Mouridsen, Ht, Fehm, T, Trampisch, Hj, Dalesio, O, De Vries Ege, Rodenhuis, S, Van Tinteren, H, Comis, Rl, Davidson, Ne, Robert, N, Sledge, G, Solin, Lj, Sparano, Ja, Tormey, Dc, Dixon, Jm, Forrest, P, Jack, W, Kunkler, I, Rossbach, J, Klijn, Jgm, Treurniet‐donker, Ad, Van Putten Wlj, Rotmensz, N, Veronesi, U, Bartelink, H, Bijker, N, Bogaerts, J, Cardoso, F, Cufer, T, Julien, Jp, Van De Velde Cjh, Cunningham, Mp, Brufsky, Am, Coleman, Re, Llombart, Ha, Huovinen, R, Joensuu, H, Costa, A, Bonadonna, G, Gianni, L, Valagussa, P, Goldstein, Lj, Bonneterre, J, Fargeot, P, Fumoleau, P, Kerbrat, P, Luporsi, E, Namer, M, Carrasco, E, Segui, Ma, Eiermann, W, Hilfrich, J, Jonat, W, Kaufmann, M, Kreienberg, R, Schumacher, M, Bastert, G, Rauschecker, H, Sauer, R, Sauerbrei, W, Schauer, A, Blohmer, Ju, Costa, Sd, Eidtmann, H, Gerber, B, Jackisch, C, De Schryver, A, Vakaet, L, Belfiglio, M, Nicolucci, A, Pellegrini, F, Pirozzoli, Mc, Sacco, M, Valentini, M, Mcardle, Cs, Smith, Dc, Stallard, S, Dent, Dm, Gudgeon, Ca, Hacking, A, Murray, E, Panieri, E, Werner, Id, Galligioni, E, Leone, B, Vallejo, Ct, Zwenger, A, Lopez, M, Erazo, A, Medina, Jy, Horiguchi, J, Takei, H, Fentiman, Is, Hayward, Jl, Rubens, Rd, Skilton, D, Scheurlen, H, Sohn, Hc, Untch, M, Dafni, U, Markopoulos, C, Fountzilas, G, Mavroudis, D, Klefstrom, P, Blomqvist, C, Saarto, T, Gallen, M, Tinterri, C, Margreiter, R, De Lafontan, B, Mihura, J, Roché, H, Asselain, B, Salmon, Rj, Vilcoq, Jr, André, F, Delaloge, S, Koscielny, S, Michiels, S, Rubino, C, A'Hern, R, Ellis, P, Kilburn, L, Yarnold, Jr, Benraadt, J, Kooi, M, Van De Velde Ao, Van Dongen Ja, Vermorken, Jb, Castiglione, M, Colleoni, M, Collins, J, Gelber, Rd, Lindtner, J, Price, Kn, Regan, Mm, Rudenstam, Cm, Senn, Hj, Thuerlimann, B, Bliss, Jm, Chilvers, Ced, Coombes, Rc, Hall, E, Marty, M, Buyse, M, Possinger, K, Schmid, P, Wallwiener, D, Bighin, C, Bruzzi, P, Del Mastro, L, Dozin, B, Pastorino, S, Pronzato, P, Sertoli, Mr, Foster, L, George, Wd, Stewart, Hj, Stroner, P, Borovik, R, Hayat, H, Inbar, Mj, Peretz, T, Robinson, E, Camerini, T, Formelli, F, Martelli, G, Di Mauro Mg, Perrone, F, Amadori, D, Martoni, A, Pannuti, F, Camisa, R, Musolino, A, Passalacqua, R, Iwata, H, Shien, T, Ikeda, T, Inokuchi, K, Sawa, K, Sonoo, H, Sadoon, M, Tulusan, Ah, Kohno, N, Miyashita, M, Takao, S, Ahn, Jh, Jung, Kh, Korzeniowski, S, Skolyszewski, J, Ogawa, M, Yamashita, J, Bastiaannet, E, Liefers, Gj, Christiaens, R, Neven, P, Paridaens, R, Van Den Bogaert, W, Braun, S, Martin, P, Romain, S, Janauer, M, Seifert, M, Sevelda, P, Zielinski, Cc, Hakes, T, Hudis, Ca, Wittes, R, Giokas, G, Kondylis, D, Lissaios, B, De La Huerta, R, Sainz, Mg, Ro, J, Camphausen, K, Danforth, D, Lichter, A, Lippman, M, Smart, D, Steinberg, S, D’Amico, C, Lioce, M, Paradiso, A, Ohno, S, Bass, G, Brown, A, Bryant, J, Dignam, J, Fisher, B, Geyer, C, Mamounas, Ep, Redmond, C, Wickerham, L, Aihara, T, Hozumi, Y, Baum, M, Jackson, Im, Palmer, Mk, Ingle, Jn, Suman, Vj, Bengtsson, No, Emdin, S, Jonsson, H, Venturini, M, Lythgoe, Jp, Kissin, M, Erikstein, B, Hannisdal, E, Jacobsen, Ab, Reinertsen, Kv, Varhaug, Je, Gundersen, S, Hauer‐jensen, M, Høst, H, Nissen‐meyer, R, Mitchell, Ak, Robertson, Jfr, Ueo, H, Di Palma, M, Mathé, G, Misset, Jl, Levine, M, Morimoto, K, Takatsuka, Y, Crossley, E, Harris, A, Talbot, D, Taylor, M, Cocconi, G, Di Blasio, B, Ivanov, V, Paltuev, R, Semiglazov, V, Brockschmidt, J, Cooper, Mr, Falkson, Ci, Hadji, P, A’Hern, R, Makris, A, Parton, M, Pennert, K, Powles, Tj, Smith, Ie, Gazet, Jc, Browne, L, Graham, P, Corcoran, N, Clack, G, Van Poznak, C, Deshpande, N, Di Martino, L, Douglas, P, Lindtner, A, Notter, G, Bryant, Ajs, Ewing, Gh, Firth, La, Krushen‐kosloski, Jl, Anderson, H, Killander, F, Malmström, P, Rydén, L, Arnesson, Lg, Carstensen, J, Dufmats, M, Fohlin, H, Nordenskjöld, B, Söderberg, M, Carpenter, Jt, Murray, N, Royle, Gt, Simmonds, Pd, Crowley, J, Gralow, J, Hortobagyi, G, Livingston, R, Martino, S, Osborne, Ck, Ravdin, Pm, Bondesson, T, Celebioglu, F, Dahlberg, K, Fornander, T, Fredriksson, I, Frisell, J, Göransson, E, Iiristo, M, Johansson, U, Lenner, E, Löfgren, L, Nikolaidis, P, Perbeck, L, Rotstein, S, Sandelin, K, Skoog, L, Svane, G, Af Trampe, E, Wadström, C, Maibach, R, Thürlimann, B, Holli, K, Rouhento, K, Safra, T, Brenner, H, Hercbergs, A, Yoshimoto, M, Paterson, Ahg, Fyles, A, Meakin, Jw, Panzarella, T, Bahi, J, Lemonnier, J, Martin, Al, Reid, M, Spittle, M, Bishop, H, Bundred, Nj, Forsyth, S, Pinder, Se, Deutsch, Gp, Kwong, Dlw, Pai, Vr, Senanayake, F, Rubagotti, A, Hackshaw, A, Houghton, J, Ledermann, J, Monson, K, Tobias, Js, Carlomagno, C, De Laurentiis, M, De Placido, S, Williams, L, Bell, R, Hinsley, S, Marshall, Hc, Pierce, Lj, Solomayer, E, Horsman, Jm, Lester, J, Winter, Mc, Buzdar, Au, Hsu, L, Love, Rr, Ahlgren, J, Garmo, H, Holmberg, L, Liljegren, G, Lindman, H, Wärnberg, F, Asmar, L, Jones, Se, Aft, R, Gluz, O, Liedtke, C, Nitz, U, Litton, A, Wallgren, A, Karlsson, P, Linderholm, Bk, Chlebowski, Rt, Caffier, H., Guided Treatment in Optimal Selected Cancer Patients (GUTS), Other departments, CCA - Cancer Treatment and Quality of Life, Radiotherapy, Pan, Hongchao, Gray, Richard, Braybrooke, Jeremy, Davies, Christina, Taylor, Carolyn, Mcgale, Paul, Peto, Richard, Pritchard, Kathleen I, Bergh, Jona, Dowsett, Mitch, Hayes, Daniel F, De Laurentiis, Michelino, MUMC+: MA Medische Oncologie (9), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, and Interne Geneeskunde

Subjects
0301 basic medicine, Oncology, medicine.medical_treatment, Kaplan-Meier Estimate, law.invention, 0302 clinical medicine, Randomized controlled trial, law, Recurrence, Receptors, Neoplasm Metastasis, AMERICAN SOCIETY, Adjuvant, CLINICAL-PRACTICE GUIDELINE, Absolute risk reduction, Estrogen Antagonists, General Medicine, Estrogen Antagonist, CHEMOTHERAPY, Middle Aged, Prognosis, Neoplasm Metastasi, Local, POSTMENOPAUSAL WOMEN, Receptors, Estrogen, Chemotherapy, Adjuvant, 030220 oncology & carcinogenesis, Meta-analysis, Lymphatic Metastasis, Female, Human, Estrogen Antagonists/therapeutic use, Adult, Risk, medicine.medical_specialty, Prognosi, medicine.drug_class, DISCONTINUATION, Breast Neoplasms, Article, Drug Administration Schedule, LATE DISTANT RECURRENCE, 03 medical and health sciences, Breast cancer, Breast Neoplasms/drug therapy, Internal medicine, SCORE, medicine, Humans, SURGICAL ADJUVANT BREAST, Aged, Proportional Hazards Models, Chemotherapy, business.industry, Proportional hazards model, Lymphatic Metastasi, TAMOXIFEN THERAPY, ta3122, medicine.disease, Estrogen, RANDOMIZED-TRIALS, Discontinuation, Surgery, Neoplasm Recurrence, 030104 developmental biology, Proportional Hazards Model, Neoplasm Grading, Neoplasm Recurrence, Local, business
Abstract

Background The administration of endocrine therapy for 5 years substantially reduces recurrence rates during and after treatment in women with early-stage, estrogen-receptor (ER)–positive breast cancer. Extending such therapy beyond 5 years offers further protection but has additional side effects. Obtaining data on the absolute risk of subsequent distant recurrence if therapy stops at 5 years could help determine whether to extend treatment. Methods In this meta-analysis of the results of 88 trials involving 62,923 women with ER-positive breast cancer who were disease-free after 5 years of scheduled endocrine therapy, we used Kaplan–Meier and Cox regression analyses, stratified according to trial and treatment, to assess the associations of tumor diameter and nodal status (TN), tumor grade, and other factors with patients’ outcomes during the period from 5 to 20 years. Results Breast-cancer recurrences occurred at a steady rate throughout the study period from 5 to 20 years. The risk of distant recurrence was strongly correlated with the original TN status. Among the patients with stage T1 disease, the risk of distant recurrence was 13% with no nodal involvement (T1N0), 20% with one to three nodes involved (T1N1–3), and 34% with four to nine nodes involved (T1N4–9); among those with stage T2 disease, the risks were 19% with T2N0, 26% with T2N1–3, and 41% with T2N4–9. The risk of death from breast cancer was similarly dependent on TN status, but the risk of contralateral breast cancer was not. Given the TN status, the factors of tumor grade (available in 43,590 patients) and Ki-67 status (available in 7692 patients), which are strongly correlated with each other, were of only moderate independent predictive value for distant recurrence, but the status regarding the progesterone receptor (in 54,115 patients) and human epidermal growth factor receptor type 2 (HER2) (in 15,418 patients in trials with no use of trastuzumab) was not predictive. During the study period from 5 to 20 years, the absolute risk of distant recurrence among patients with T1N0 breast cancer was 10% for low-grade disease, 13% for moderate-grade disease, and 17% for high-grade disease; the corresponding risks of any recurrence or a contralateral breast cancer were 17%, 22%, and 26%, respectively. Conclusions After 5 years of adjuvant endocrine therapy, breast-cancer recurrences continued to occur steadily throughout the study period from 5 to 20 years. The risk of distant recurrence was strongly correlated with the original TN status, with risks ranging from 10 to 41%, depending on TN status and tumor grade. (Funded by Cancer Research UK and others.)

Published
2017

26. Long-term outcomes for neoadjuvant versus adjuvant chemotherapy in early breast cancer: meta-analysis of individual patient data from ten randomised trials

Author

Alberro, JA, Ballester, B, Deulofeu, P, Fabregas, R, Fraile, M, Gubern, JM, Janer, J, Moral, A, de Pablo, JL, Penalva, G, Puig, P, Ramos, M, Rojo, R, Santesteban, P, Serra, C, Sola, M, Solarnau, L, Solsona, J, Veloso, E, Vidal, S, Abe, O, Abe, R, Enomoto, K, Kikuchi, K, Koyama, H, Masuda, H, Nomura, Y, Ohashi, Y, Sakai, K, Sugimachi, K, Toi, M, Tominaga, T, Uchino, J, Yoshida, M, Coles, CE, Haybittle, JL, Moebus, V, Leonard, CF, Calais, G, Garaud, P, Collett, V, Davies, C, Delmestri, A, Sayer, J, Harvey, VJ, Holdaway, IM, Kay, RG, Mason, BH, Forbe, JF, Franci, PA, Wilcken, N, Balic, M, Bartsch, R, Fesl, C, Fitzal, F, Fohler, H, Gnant, M, Greil, R, Jakesz, R, Marth, C, Mlineritsch, B, Pfeiler, G, Singer, CF, Steger, GG, Stoeger, H, Canney, P, Yosef, HMA, Focan, C, Peek, U, Oates, GD, Powell, J, Durand, M, Mauriac, L, Di Leo, A, Dolci, S, Larsimont, D, Nogaret, JM, Philippson, C, Piccart, MJ, Masood, MB, Parker, D, Price, JJ, Lindsay, MA, Mackey, J, Martin, M, Hupperets, PSGJ, Bates, T, Blamey, RW, Chetty, U, Ellis, IO, Mallon, E, Morgan, DAL, Patnick, J, Pinder, S, Lohrisch, C, Nichol, A, Bartlett, JMS, Bramwell, VH, Chen, BE, Chia, SKL, Gelmon, K, Goss, PE, Levine, MN, Parulekar, W, Pater, JL, Pritchard, KI, Shepherd, LE, Tu, D, Whelan, T, Berry, D, Broadwater, G, Cirrincione, C, Muss, H, Norton, L, Weiss, RB, Abu-Zahara, HT, Karpov, A, Portnoj, SL, Bowden, S, Brookes, C, Dunn, J, Fernando, I, Lee, M, Poole, C, Rea, D, Spooner, D, Barrett-Lee, PJ, Manse, RE, Monypenny, IJ, Gordon, NH, Davis, HL, Cuzick, J, Sestak, I, Lehingue, Y, Romestaing, P, Dubois, JB, Delozier, T, Griffon, B, Lesec'h, J Mace, Mustacchi, G, Petruzelka, L, Pribylova, O, Owen, JR, Meier, P, Shan, Y, Shao, YF, Wang, X, Zhao, DB, Howell, A, Swindell, R, Albano, J, de Oliveira, CF, Gervasio, H, Gordilho, J, Ejlertsen, B, Jensen, M-B, Mouridsen, H, Gelman, RS, Harris, JR, Hayes, D, Henderson, C, Shapiro, CL, Christiansen, P, Ewertz, M, Jensen, MB, Mouridsen, HT, Fehm, T, Trampisch, HJ, Dalesio, O, de Vries, EGE, Rodenhuis, S, van Tinteren, H, Comis, RL, Davidson, NE, Gray, R, Robert, N, Sledge, G, Solin, LJ, Sparano, JA, Tormey, DC, Wood, W, Cameron, D, Dixon, JM, Forrest, P, Jack, W, Kunkler, I, Rossbach, J, Klijn, JGM, Treurniet-Donker, AD, van Putten, WLJ, Rotmensz, N, Veronesi, U, Viale, G, Bartelink, H, Bijker, N, Bogaerts, J, Cardoso, F, Cufer, T, Julien, JP, Poortmans, PM, Rutgers, E, van de Velde, CJH, Cunningham, MP, Huovinen, R, Joensuu, H, Costa, A, Bonadonna, G, Gianni, L, Valagussa, P, Goldstein, LJ, Bonneterre, J, Fargeot, P, Fumoleau, P, Kerbrat, P, Lupors, E, Namer, M, Carrasco, E, Segui, MA, Eierman, W, Hilfrich, J, Jonat, W, Kaufmann, M, Kreienberg, R, Schumacher, M, Bastert, G, Rauschecker, H, Sauer, R, Sauerbrei, W, Schauer, A, Blohmer, JU, Costa, SD, Eidtmann, H, Gerber, B, Jackisch, C, Loib, S, von Minckwitz, G, de Schryver, A, Vakaet, L, Belfiglio, M, Nicolucci, A, Pellegrini, F, Pirozzoli, MC, Sacco, M, Valentini, M, McArdle, CS, Smith, DC, Stallard, S, Dent, DM, Gudgeon, CA, Hacking, A, Murray, E, Panieri, E, Werner, ID, De Salvo, GL, Del Bianco, P, Zavagno, G, Leone, B, Vallejo, CT, Zwenger, A, Galligioni, E, Lopez, M, Erazo, A, Medina, JY, Horiguchi, J, Takei, H, Fentiman, IS, Hayward, JL, Rubens, RD, Skilton, D, Scheurlen, H, Sohn, HC, Untch, M, Dafni, U, Markopoulos, C, Bamia, C, Fountzilas, G, Koliou, G-A, Manousou, K, Mavroudis, D, Klefstrom, P, Blomqvist, C, Saarto, T, Gallen, M, Canavese, G, Tinterri, C, Margreiter, R, de Lafontan, B, Mihura, J, Roche, H, Asselain, B, Salmon, RJ, Vilcoq, JR, Brain, E, de La Lande, B, Mouret-Fourme, E, Andre, F, Arriagada, R, Delaloge, S, Hill, C, Koscienly, S, Michiels, S, Rubino, C, A'Hern, R, Bliss, J, Ellis, P, Kilburn, L, Yarnold, JR, Benraadt, J, Kooi, M, van de Velde, AO, van Dongen, JA, Vermorken, JB, Castiglione, M, Coates, A, Colleoni, M, Collins, J, Forbes, J, Gelbe, RD, Goldhirsch, A, Lindtner, J, Price, KN, Regan, MM, Rudenstam, CM, Senn, HJ, Thuerlimann, B, Bliss, JM, Chilvers, CED, Coombes, RC, Hall, E, Marty, M, Buyse, M, Possinger, K, Schmid, P, Wallwiener, D, Foster, L, George, WD, Stewart, HJ, Stroner, P, Borovik, R, Hayat, H, Inbar, MJ, Peretz, T, Robinson, E, Camerini, T, Formelli, F, Martelli, G, Di Mauro, MG, Perrone, F, Amadori, D, Martoni, A, Pannuti, F, Camisa, R, Musolino, A, Passalacqua, R, Iwata, H, Shien, T, Ikeda, T, Inokuchi, K, Sawa, K, Sonoo, H, Sadoon, M, Tulusan, AH, Kohno, N, Miyashita, M, Takao, S, Ahn, J-H, Jung, KH, Korzeniowski, S, Skolyszewski, J, Ogawa, M, Yamashita, J, Bastiaannet, E, Liefers, GJ, Christiaens, R, Neven, P, Paridaens, R, Van den Bogaert, W, Gazet, JC, Corcoran, N, Deshpande, N, di Martino, L, Douglas, P, Host, H, Lindtner, A, Notter, G, Bryant, AJS, Ewing, GH, Firth, LA, Krushen-Kosloski, JL, Nissen-Meyer, R, Anderson, H, Killander, F, Malmstrom, P, Ryden, L, Arnesson, L-G, Carstense, J, Dufmats, M, Fohlin, H, Nordenskjold, B, Soderberg, M, Sundqvist, M, Carpenter, TJ, Murray, N, Royle, GT, Simmonds, PD, Albain, K, Barlow, W, Crowley, J, Gralow, J, Hortobagyi, G, Livingston, R, Martino, S, Osborne, CK, Ravdin, PM, Bergh, J, Bondesso, T, Celebiogl, F, Dahlberg, K, Fornander, T, Fredriksson, I, Frisell, J, Goransson, E, Iiristo, M, Johansson, U, Lenner, E, Lofgren, L, Nikolaidis, P, Perbeck, L, Rotstein, S, Sandelin, K, Skoog, L, Svane, G, af Trampe, E, Wadstrom, C, Janni, W, Maibach, R, Thurlimann, B, Hadji, P, Hozumi, J, Holli, K, Rouhento, K, Safra, T, Brenner, H, Hercbergs, A, Yoshimoto, M, Paterson, AHG, Fyles, A, Meakin, JW, Panzarella, T, Bahi, J, Lemonnier, J, Martin, AL, Reid, M, Spittle, M, Bishop, H, Bundred, NJ, Forbes, JF, Forsyth, S, George, WS, Pinder, SE, Deutsch, GP, Kwong, DLW, Pai, VR, Peto, R, Senanayake, F, Boccardo, F, Rubagotti, A, Baum, M, Hackshaw, A, Houghton, J, Ledermann, J, Monson, K, Tobias, JS, Carlomagno, C, De Laurentiis, M, De Placido, S, Schem, C, Williams, L, Bell, R, Coleman, RE, Dodwell, D, Hinsley, S, Marshall, HC, Pierce, LJ, Basso, SMM, Lumachi, F, Solomayer, E, Horsman, JM, Lester, J, Winter, MC, Buzdar, AU, Hsu, L, Love, RR, Ahlgren, J, Garmo, H, Holmberg, L, Lindman, H, Warnberg, F, Asmar, L, Jones, SE, Aft, R, Gluz, O, Harbeck, N, Liedtke, C, Nitz, U, Litton, A, Wallgren, A, Karlsson, P, Linderholm, BK, Chlebowski, RT, Caffier, H, Brufsky, AM, Llombart, HA, Asselain, B, Barlow, W, Bartlett, J, Bradley, R, Braybrooke, J, Davies, C, Dodwell, D, Gray, R, Mannu, G, Taylor, C, Peto, R, McGale, P, Pan, H, Wang, Y, Wang, Z, Department of Oncology, Clinicum, HUS Comprehensive Cancer Center, Medical Oncology, Cancer Research UK, and Pfizer Limited

Subjects
0301 basic medicine, Oncology, Time Factors, SURGERY, medicine.medical_treatment, menopause, chemotherapy, Mastectomy, Segmental, Rate ratio, THERAPY, aromatase inhibitors, CEA, 0302 clinical medicine, Risk Factors, Medicine and Health Sciences, Breast, Neoplasm Metastasis, Randomized Controlled Trials as Topic, RISK, tamoxifen, breast tumor, CA15-3, axillary dissection, mastectomy, Middle Aged, Neoadjuvant Therapy, METHOTREXATE, 3. Good health, trastuzumab, Treatment Outcome, quadrantectomy, Chemotherapy, Adjuvant, axillary lymphnodes, 030220 oncology & carcinogenesis, Meta-analysis, SURVIVAL, Disease Progression, Female, Life Sciences & Biomedicine, axillary clearance, RADIOTHERAPY, medicine.drug, Adult, medicine.medical_specialty, Anthracycline, 3122 Cancers, Antineoplastic Agents, Breast Neoplasms, axillary nodes, sentinel node biopsy, 03 medical and health sciences, breast cancer, Breast cancer, SDG 3 - Good Health and Well-being, HER2, Internal medicine, Journal Article, medicine, cancer, Humans, Breast, breast cancer, breast diseases, cancer, malignancy, menopause, surgery, mastectomy, quadrantectomy, lumpectomy, axillary nodes, axillary lymphnodes, axillary dissection, axillary clearance, sentinel node biopsy, sentinel node, BRCA1, BRCA2, tamoxifen, aromatase inhibitors, breast tumor, osteoporosis, bisphosphonates, denosumab, trastuzumab, HER2, CEA, CA15-3, tumor marker, chemotherapy, endocrine therapy, Oncology & Carcinogenesis, RECURRENCE, bisphosphonates, Pathological, Neoplasm Staging, lumpectomy, Chemotherapy, Science & Technology, breast diseases, endocrine therapy, business.industry, denosumab, BRCA1, medicine.disease, BRCA2, osteoporosis, Radiation therapy, STIMULATING FACTOR, 030104 developmental biology, sentinel node, tumor marker, Methotrexate, Neoplasm Recurrence, Local, business, 1112 Oncology And Carcinogenesis, malignancy
Abstract

BACKGROUND: Neoadjuvant chemotherapy (NACT) for early breast cancer can make breast-conserving surgery more feasible and might be more likely to eradicate micrometastatic disease than might the same chemotherapy given after surgery. We investigated the long-term benefits and risks of NACT and the influence of tumour characteristics on outcome with a collaborative meta-analysis of individual patient data from relevant randomised trials. METHODS: We obtained information about prerandomisation tumour characteristics, clinical tumour response, surgery, recurrence, and mortality for 4756 women in ten randomised trials in early breast cancer that began before 2005 and compared NACT with the same chemotherapy given postoperatively. Primary outcomes were tumour response, extent of local therapy, local and distant recurrence, breast cancer death, and overall mortality. Analyses by intention-to-treat used standard regression (for response and frequency of breast-conserving therapy) and log-rank methods (for recurrence and mortality). FINDINGS: Patients entered the trials from 1983 to 2002 and median follow-up was 9 years (IQR 5-14), with the last follow-up in 2013. Most chemotherapy was anthracycline based (3838 [81%] of 4756 women). More than two thirds (1349 [69%] of 1947) of women allocated NACT had a complete or partial clinical response. Patients allocated NACT had an increased frequency of breast-conserving therapy (1504 [65%] of 2320 treated with NACT vs 1135 [49%] of 2318 treated with adjuvant chemotherapy). NACT was associated with more frequent local recurrence than was adjuvant chemotherapy: the 15 year local recurrence was 21·4% for NACT versus 15·9% for adjuvant chemotherapy (5·5% increase [95% CI 2·4-8·6]; rate ratio 1·37 [95% CI 1·17-1·61]; p=0·0001). No significant difference between NACT and adjuvant chemotherapy was noted for distant recurrence (15 year risk 38·2% for NACT vs 38·0% for adjuvant chemotherapy; rate ratio 1·02 [95% CI 0·92-1·14]; p=0·66), breast cancer mortality (34·4% vs 33·7%; 1·06 [0·95-1·18]; p=0·31), or death from any cause (40·9% vs 41·2%; 1·04 [0·94-1·15]; p=0·45). INTERPRETATION: Tumours downsized by NACT might have higher local recurrence after breast-conserving therapy than might tumours of the same dimensions in women who have not received NACT. Strategies to mitigate the increased local recurrence after breast-conserving therapy in tumours downsized by NACT should be considered-eg, careful tumour localisation, detailed pathological assessment, and appropriate radiotherapy. FUNDING: Cancer Research UK, British Heart Foundation, UK Medical Research Council, and UK Department of Health. ispartof: LANCET ONCOLOGY vol:19 issue:1 pages:27-39 ispartof: location:England status: published

Published
2017

27. Alignment of the optical feedback system of VUV regenerative FEL amplifier at the TESLA test facility at DESY

Author

Faatz, B., Fateev, A.A., Feldhaus, J., Gerth, Ch., Hahn, U., Jastrow, U., Krzywinski, J., Lebedev, N.I., Lewellen, J., Malkinski, L., Meschkat, M., Petrov, V.A., Rossbach, J., Rukoyatkina, T.V., Saldin, E.L., Schneidmiller, E.A., Schreiber, S., Sedykh, S.N., Shvetsov, V.S., Sobierajski, R., Sytchev, K.P., Tarasov, V.V., Tiedtke, K., Treusch, R., and Yurkov, M.V.

Published
2002
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34. Control of FEL radiation properties by tailoring the seed pulses

Author

Grattoni, V., primary, Assmann, R. W., additional, Bödewadt, J., additional, Lechner, C., additional, Kazemi, M. M., additional, Manschwetus, B., additional, Hartl, I., additional, Plath, T., additional, Khan, S., additional, Azima, A., additional, Hillert, W., additional, Miltchev, V., additional, and Rossbach, J., additional

Published
2018
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35. An Option to Generate Seeded FEL Radiation for FLASH1

Author

Grattoni, V., primary, Assmann, R. W., additional, Bödewadt, J., additional, Lechner, C., additional, Kazemi, M. M., additional, Manschwetus, B., additional, Hartl, I., additional, Plath, T., additional, Khan, S., additional, Hillert, W., additional, Miltchev, V., additional, and Rossbach, J., additional

Published
2018
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36. Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials

Author

Mcgale, P., Taylor, C., Correa, C., Cutter, D., Duane, F., Ewertz, M., Gray, R., Mannu, G., Peto, R., Whelan, T., Wang, Y., Wang, Z., Darby, S., Albain, K., Anderson, S., Arriagada, R., Barlow, W., Bergh, J., Bergsten Nordström, E., Bliss, J., Burrett, J. A., Buyse, M., Cameron, D., Carrasco, E., Clarke, M., Coleman, R., Coates, A., Collins, R., Costantino, J., Cuzick, J., Davidson, N., Davies, C., Davies, K., Delmestri, A., Di Leo, A., Dowsett, M., Elphinstone, P., Evans, V., Forbes, J., Gelber, R., Gettins, L., Geyer, C., Gianni, L., Gnant, M., Goldhirsch, A., Godwin, J., Gregory, C., Hayes, D., Hill, C., Ingle, J., Jakesz, R., James, S., Janni, W., Kaufmann, M., Kerr, A., Liu, H., Mackinnon, E., Martín, M., Mchugh, T., Morris, P., Norton, L., Ohashi, Y., Paik, S., Pan, H. C., Perez, E., Piccart, M., Pierce, L., Pritchard, K., Pruneri, G., Raina, V., Ravdin, P., Robertson, J., Rutgers, E., Shao, Y. F., Sparano, J., Swain, S., Valagussa, P., Viale, G., Von Minckwitz, G., Winer, E., Wiang, X., Wood, Abe O, W., Abe, R, Enomoto, K, Kikuchi, K, Koyama, H, Masuda, H, Nomura, Y, Ohashi, Y, Sakai, K, Sugimachi, K, Toi, M, Tominaga, T, Uchino, J, Yoshida, M, Haybittle, Jl, Leonard, Cf, Calais, G, Geraud, P, Collett, V, Davies, C, Delmestri, A, Sayer, J, Harvey, Vj, Holdaway, Im, Kay, Rg, Mason, Bh, Forbes, Jf, Wilcken, N, Bartsch, R, Dubsky, P, Fesl, C, Fohler, H, Gnant, M, Greil, R, Jakesz, R, Lang, A, Luschin-Ebengreuth, G, Marth, C, Mlineritsch, B, Samonigg, H, Singer, Cf, Steger, Gg, Stöger, H, Canney, P, Yosef, Hm, Focan, C, Peek, U, Oates, Gd, Powell, J, Durand, M, Mauriac, L, Di Leo, A, Dolci, S, Larsimont, D, Nogaret, Jm, Philippson, C, Piccart, Mj, Masood, Mb, Parker, D, Price, Jj, Lindsay, Ma, Mackey, J, Martin, M, Hupperets, Ps, Bates, T, Blamey, Rw, Chetty, U, Ellis, Io, Mallon, E, Morgan, Da, Patnick, J, Pinder, S, Olivotto, I, Ragaz, J, Berry, D, Broadwater, G, Cirrincione, C, Muss, H, Norton, L, Weiss, Rb, Abu-Zahra, Ht, Portnoj, Sm, Bowden, S, Brookes, C, Dunn, J, Fernando, I, Lee, M, Poole, C, Rea, D, Spooner, D, Barrett-Lee, Pj, Mansel, Re, Monypenny, Ij, Gordon, Nh, Davis, Hl, Cuzick, J, Lehingue, Y, Romestaing, P, Dubois, Jb, Delozier, T, Griffon, B, Mace Lesech, J, Brain, E, de La Lande, B, Mouret-Fourme, E, Mustacchi, G, Petruzelka, L, Pribylova, O, Owen, Jr, Harbeck, N, Jänicke, F, Meisner, C, Schmitt, M, Thomssen, C, Meier, P, Shan, Y, Shao, Yf, Wang, X, Zhao, Db, Chen, Zm, Pan, Hc, Howell, A, Swindell, R, Burrett, Ja, Clarke, M, Collins, R, Correa, C, Cutter, D, Darby, S, Davies, K, Elphinstone, P, Evans, V, Gettins, L, Godwin, J, Gray, R, Gregory, C, Hermans, D, Hicks, C, James, S, Kerr, A, Liu, H, Mackinnon, E, Lay, M, Mcgale, P, Mchugh, T, Morris, P, Peto, R, Taylor, C, Wang, Y, Albano, J, de Oliveira CF, Gervásio, H, Gordilho, J, Ejlertsen, B, Jensen, Mb, Johansen, H, Mouridsen, H, Palshof, T, Gelman, Rs, Harris, Jr, Hayes, D, Henderson, C, Shapiro, Cl, Winer, E, Christiansen, P, Ewertz, M, Møller, S, Mouridsen, Ht, Trampisch, Hj, Dalesio, O, de Vries EG, Rodenhuis, S, van Tinteren, H, Comis, Rl, Davidson, Ne, Robert, N, Sledge, G, Solin, Lj, Sparano, Ja, Tormey, Dc, Wood, W, Cameron, D, Dixon, Jm, Forrest, P, Jack, W, Kunkler, I, Rossbach, J, Klijn, Jg, Treurniet-Donker, Ad, van Putten WL, Rotmensz, N, Veronesi, U, Viale, G, Bartelink, H, Bijker, N, Bogaerts, J, Cardoso, F, Cufer, T, Julien, Jp, Rutgers, E, van de Velde CJ, Cunningham, Mp, Huovinen, R, Joensuu, H, Costa, A, Bonadonna, G, Gianni, L, Valagussa, P, Goldstein, Lj, Bonneterre, J, Fargeot, P, Fumoleau, P, Kerbrat, P, Luporsi, E, Namer, M, Eiermann, W, Hilfrich, J, Jonat, W, Kaufmann, M, Kreienberg, R, Schumacher, M, Bastert, G, Rauschecker, H, Sauer, R, Sauerbrei, W, Schauer, A, Blohmer, Ju, Costa, Sd, Eidtmann, H, Gerber, B, Jackisch, C, Loibl, S, von Minckwitz, G, de Schryver, A, Vakaet, L, Belfiglio, M, Nicolucci, A, Pellegrini, F, Pirozzoli, Mc, Sacco, M, Valentini, M, Mcardle, Cs, Smith, Dc, Stallard, S, Dent, Dm, Gudgeon, Ca, Hacking, A, Murray, E, Panieri, E, Werner, Id, Carrasco, E, Segui, Ma, Galligioni, E, Lopez, M, Erazo, A, Medina, Jy, Horiguchi, J, Takei, H, Fentiman, Is, Hayward, Jl, Rubens, Rd, Skilton, D, Scheurlen, H, Sohn, Hc, Untch, M, Dafni, U, Markopoulos, C, Fountzilas, G, Mavroudis, D, Klefstrom, P, Blomqvist, C, Saarto, T, Gallen, M, Tinterri, C, Margreiter, R, de Lafontan, B, Mihura, J, Roché, H, Asselain, B, Salmon, Rj, Vilcoq, Jr, André, F, Arriagada, R, Delaloge, S, Hill, C, Koscielny, S, Michiels, S, Rubino, C, A'Hern, R, Bliss, J, Ellis, P, Kilburn, L, Yarnold, Jr, Benraadt, J, Kooi, M, van de Velde AO, van Dongen JA, Vermorken, Jb, Castiglione, M, Coates, A, Colleoni, M, Collins, J, Forbes, J, Gelber, Rd, Goldhirsch, A, Lindtner, J, Price, Kn, Regan, Mm, Rudenstam, Cm, Senn, Hj, Thuerlimann, B, Bliss, Jm, Chilvers, Ce, Coombes, Rc, Hall, E, Marty, M, Buyse, M, Possinger, K, Schmid, P, Wallwiener, D, Foster, L, George, Wd, Stewart, Hj, Stroner, P, Borovik, R, Hayat, H, Inbar, Mj, Peretz, T, Robinson, E, Bruzzi, P, Del Mastro, L, Pronzato, P, Sertoli, Mr, Venturini, M, Camerini, T, De Palo, G, Di Mauro MG, Formelli, F, Amadori, D, Martoni, A, Pannuti, F, Camisa, R, Cocconi, G, Colozza, A, Passalacqua, R, Aogi, K, Takashima, S, Abe, O, Ikeda, T, Inokuchi, K, Sawa, K, Sonoo, H, Korzeniowski, S, Skolyszewski, J, Ogawa, M, Yamashita, J, Bastiaannet, E, van de Water, W, van Nes JG, Christiaens, R, Neven, P, Paridaens, R, Van den Bogaert, W, Braun, S, Martin, P, Romain, S, Janauer, M, Seifert, M, Sevelda, P, Zielinski, Cc, Hakes, T, Hudis, Ca, Wittes, R, Giokas, G, Kondylis, D, Lissaios, B, de la Huerta, R, Sainz, Mg, Altemus, R, Camphausen, K, Cowan, K, Danforth, D, Lichter, A, Lippman, M, O'Shaughnessy, J, Pierce, Lj, Steinberg, S, Venzon, D, Zujewski, Ja, D'Amico, C, Lioce, M, Paradiso, A, Chapman, Ja, Gelmon, K, Goss, Pe, Levine, Mn, Meyer, R, Parulekar, W, Pater, Jl, Pritchard, Ki, Shepherd, Le, Tu, D, Whelan, T, Ohno, S, Anderson, S, Bass, G, Brown, A, Bryant, J, Costantino, J, Dignam, J, Fisher, B, Geyer, C, Mamounas, Ep, Paik, S, Redmond, C, Swain, S, Wickerham, L, Wolmark, N, Baum, M, Jackson, Im, Palmer, Mk, Perez, E, Ingle, Jn, Suman, Vj, Bengtsson, No, Emdin, S, Jonsson, H, Lythgoe, Jp, Kissin, M, Erikstein, B, Hannisdal, E, Jacobsen, Ab, Varhaug, Je, Gundersen, S, Hauer-Jensen, M, Høst, H, Nissen-Meyer, R, Reinertsen, K, Mitchell, Ak, Robertson, Jf, Ueo, H, Di Palma, M, Mathé, G, Misset, Jl, Levine, M, Morimoto, K, Takatsuka, Y, Crossley, E, Harris, A, Talbot, D, Taylor, M, di Blasio, B, Ivanov, V, Paltuev, R, Semiglazov, V, Brockschmidt, J, Cooper, Mr, Falkson, Ci, Dowsett, M, Makris, A, Parton, M, Pennert, K, Powles, Tj, Smith, Ie, Gazet, Jc, Browne, L, Graham, P, Corcoran, N, Businico, A, Deshpande, N, di Martino, L, Douglas, P, Lindtner, A, Notter, G, Bryant, Aj, Ewing, Gh, Firth, La, Krushen-Kosloski, Jl, Anderson, H, Killander, F, Malmström, P, Rydén, L, Arnesson, Lg, Carstensen, J, Dufmats, M, Fohlin, H, Nordenskjöld, B, Söderberg, M, Carpenter, Jt, Murray, N, Royle, Gt, Simmonds, Pd, Albain, K, Barlow, W, Crowley, J, Gralow, J, Hortobagyi, G, Livingston, R, Martino, S, Osborne, Ck, Ravdin, Pm, Adolfsson, J, Bergh, J, Bondesson, T, Celebioglu, F, Dahlberg, K, Fornander, T, Fredriksson, I, Frisell, J, Göransson, E, Iiristo, M, Johansson, U, Lenner, E, Löfgren, L, Nikolaidis, P, Perbeck, L, Rotstein, S, Sandelin, K, Skoog, L, Svane, G, af Trampe, E, Wadström, C, Janni, W, Maibach, R, Thürlimann, B, Hakama, M, Holli, K, Isola, J, Rouhento, K, Saaristo, R, Brenner, H, Hercbergs, A, Yoshimoto, M, Paterson, Ah, Fyles, A, Meakin, Jw, Panzarella, T, Bahi, J, Reid, M, Spittle, M, Bishop, H, Bundred, Nj, Forsyth, S, Pinder, Se, Sestak, I, Deutsch, Gp, Kwong, Dl, Pai, Vr, Senanayake, F, Martin, Al, Boccardo, F, Rubagotti, A, Hackshaw, A, Houghton, J, Ledermann, J, Monson, K, Tobias, Js, Carlomagno, C, De Laurentiis, M, De Placido, S, Williams, L, Broglio, K, Buzdar, Au, Hsu, L, Love, Rr, Ahlgren, J, Garmo, H, Holmberg, L, Liljegren, G, Lindman, H, Wärnberg, F, Asmar, L, Jones, Se, Gluz, O, Liedtke, C, Nitz, U, Litton, A, Wallgren, A, Karlsson, P, Linderholm, Bk, Chlebowski, Rt, Caffier, H., McGale, P, Taylor, C, Correa, C, Cutter, D, Duane, F, Ewertz, M, Gray, R, Mannu, G, Peto, R, Whelan, T, Wang, Y, Wang, Z, Darby, S, Biomedische Technologie, RS: GROW - Oncology, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Mcgale, P, DE LAURENTIIS, Michelino, Other departments, CCA -Cancer Center Amsterdam, and Radiotherapy

Subjects
medicine.medical_specialty, medicine.medical_treatment, Breast Neoplasms, Rate ratio, Lower risk, Systemic therapy, Statistical significance, Medicine, Humans, Mastectomy, Randomized Controlled Trials as Topic, business.industry, Articles, General Medicine, Surgery, Radiation therapy, Axilla, Neoplasm Recurrence, medicine.anatomical_structure, Local, Meta-analysis, Lymphatic Metastasis, Lymph Node Excision, Female, Neoplasm Recurrence, Local, business, Breast Neoplasm, Human
Abstract

BACKGROUND: Postmastectomy radiotherapy was shown in previous meta-analyses to reduce the risks of both recurrence and breast cancer mortality in all women with node-positive disease considered together. However, the benefit in women with only one to three positive lymph nodes is uncertain. We aimed to assess the effect of radiotherapy in these women after mastectomy and axillary dissection.METHODS: We did a meta-analysis of individual data for 8135 women randomly assigned to treatment groups during 1964-86 in 22 trials of radiotherapy to the chest wall and regional lymph nodes after mastectomy and axillary surgery versus the same surgery but no radiotherapy. Follow-up lasted 10 years for recurrence and to Jan 1, 2009, for mortality. Analyses were stratified by trial, individual follow-up year, age at entry, and pathological nodal status.FINDINGS: 3786 women had axillary dissection to at least level II and had zero, one to three, or four or more positive nodes. All were in trials in which radiotherapy included the chest wall, supraclavicular or axillary fossa (or both), and internal mammary chain. For 700 women with axillary dissection and no positive nodes, radiotherapy had no significant effect on locoregional recurrence (two-sided significance level [2p]>0·1), overall recurrence (rate ratio [RR], irradiated vs not, 1·06, 95% CI 0·76-1·48, 2p>0·1), or breast cancer mortality (RR 1·18, 95% CI 0·89-1·55, 2p>0·1). For 1314 women with axillary dissection and one to three positive nodes, radiotherapy reduced locoregional recurrence (2pINTERPRETATION: After mastectomy and axillary dissection, radiotherapy reduced both recurrence and breast cancer mortality in the women with one to three positive lymph nodes in these trials even when systemic therapy was given. For today's women, who in many countries are at lower risk of recurrence, absolute gains might be smaller but proportional gains might be larger because of more effective radiotherapy.FUNDING: Cancer Research UK, British Heart Foundation, UK Medical Research Council.

Published
2016

37. Simultaneous Operation of Two Soft X-Ray Free-Electron Lasers Driven by One Linear Accelerator

Author

Faatz, B., Plönjes, E., Bican, Y., Meissner, D., Mildner, N., Miltchev, V., Molnar, S., Mross, D., Müller, F., Neumann, R., Neumann, P., Nölle, D., Obier, F., Bilani, O., Pelzer, M., Peters, H-B, Petersen, K., Petrosyan, A., Petrosyan, G., Petrosyan, L., Petrosyan, Vahan, Petrov, A., Pfeiffer, S., Piotrowski, A., Bödewadt, J., Pisarov, Z., Plath, T., Pototzki, P., Prandolini, M. J., Prenting, J., Priebe, G., Racky, B., Ramm, T., Rehlich, K., Riedel, R., Böhnert, M., Roggli, M., Röhling, M., Rönsch-Schulenburg, J., Rossbach, J., Rybnikov, V., Schaefer, Juergen, Schaffran, J., Schlarb, H., Schlesselmann, G., Schlösser, M., Böspflug, R., Schmid, P., Schmidt, C., Schmidt-Föhre, F., Schmitz, Michael, Schneidmiller, E., Schöps, A., Scholz, Matthias, Schreiber, Siegfried, Schuett, Katrin, Schütz, U., Bonfigt, S., Schulte-Schrepping, H., Schulz, M., Shabunov, A., Smirnov, P., Sombrowski, E., Sorokin, Andrey, Sparr, B., Spengler, J., Staack, M., Stadler, M., Bolz, H., Stechmann, C., Steffen, Boris, Stojanovic, N., Sychev, V., Syresin, E., Tanikawa, T., Tavella, F., Tesch, N., Tiedtke, K., Tischer, M., Borges, F., Treusch, R., Tripathi, S., Vagin, P., Vetrov, P., Vilcins, S., Vogt, Mathias, Wagner, A de Zubiaurre, Wamsat, T., Weddig, H., Weichert, G., Borkenhagen, O., Weigelt, H., Wentowski, N., Wiebers, Christian, Wilksen, T., Willner, A., Wittenburg, Katrin, Wohlenberg, T., Wortmann, J., Wurth, W., Yurkov, M., Brachmanski, Maciej, Zagorodnov, I., Zemella, J., Ackermann, S., Braune, M., Brinkmann, A., Brovko, Oleg, Bruns, T., Castro, P., Chen, J., Czwalinna, M. K., Damker, Horst-Guenter, Decking, W., Degenhardt, M., Agababyan, A., Delfs, A., Delfs, T., Deng, H., Dressel, M., Duhme, H-T, Düsterer, S., Eckoldt, H., Eislage, A., Felber, M., Feldhaus, J., Asgekar, V., Gessler, P., Gibau, M., Golubeva, N., Golz, T., Gonschior, J., Grebentsov, A., Grecki, M., Grün, C., Grunewald, S., Hacker, K., Ayvazyan, V., Hänisch, L., Hage, A., Hans, T., Hass, E., Hauberg, A., Hensler, O., Hesse, M., Heuck, K., Hidvegi, A., Holz, M., Baark, S., Honkavaara, K., Höppner, H., Ignatenko, A., Jäger, J., Jastrow, U., Kammering, R., Karstensen, S., Kaukher, A., Kay, H., Keil, B., Baboi, N., Klose, K., Kocharyan, V., Köpke, M., Körfer, M., Kook, W., Krause, B., Krebs, O., Kreis, S., Krivan, F., Kuhlmann, J., Balandin, V., Kuhlmann, M., Kube, G., Laarmann, T., Lechner, C., Lederer, S., Leuschner, A., Liebertz, D., Liebing, J., Liedtke, A., Lilje, L., Bargen, N von, Limberg, T., Lipka, D., Liu, B., Lorbeer, B., Ludwig, K., Mahn, H., Marinkovic, G., Martens, C., Marutzky, F., and Maslocv, M.

Subjects
ddc:530
Abstract

Extreme-ultraviolet to x-ray free-electron lasers (FELs) in operation for scientific applications are up to now single-user facilities. While most FELs generate around 100 photon pulses per second, FLASH at DESY can deliver almost two orders of magnitude more pulses in this time span due to its superconducting accelerator technology. This makes the facility a prime candidate to realize the next step in FELs—dividing the electron pulse trains into several FEL lines and delivering photon pulses to several users at the same time. Hence, FLASH has been extended with a second undulator line and self-amplified spontaneous emission (SASE) is demonstrated in both FELs simultaneously. FLASH can now deliverMHzpulse trains to two user experiments in parallel with individually selected photon beam characteristics. First results of the capabilities of this extension are shown with emphasis on independent variation of wavelength, repetition rate, and photon pulse length.

Published
2016

38. ESR operation and development

Author

Dimopoulou, C., Kelnhofer, M., Steck, M., Winters, D., Kleffner, C., Litvinov, S., Nolden, F., Peschke, C., Petridis, N., Popp, U., Roßbach, J., and Sanjari, S.

Subjects
Physics
Abstract

GSI Scientific Report 2014 - GSI Report 2015-1

Published
2015
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39. Developments for the CR Stochastic Cooling System

Author

Dimopoulou, C., Barker, D., Böhm, R., Bräscher, M., Dolinska, M., Hettrich, R., Kelnhofer, M., Krieg, J., Maier, W., Menges, R., Peschke, C., Roßbach, J., Stuhl, A., Thorndahl, L., and Wunderlich, S.

Subjects
Physics
Abstract

GSI Scientific Report 2014 - GSI Report 2015-1

Published
2015

40. Measurements of the Timing Stability at the FLASH1 Seeding Experiment

Author

Lechner, C., Azima, A., Drescher, M., Lazzarino, L. L., Maltezopoulos, Th, Miltchev, V., Plath, T., Rönsch-Schulenburg, J., Rossbach, J., Wieland, M., Hacker, K. E., Khan, S., Molo, R., Ackermann, S., Bödewadt, J., Dachraoui, H., Ekanayake, N., Faatz, B., Felber, M., Honkavaara, K., Tim Laarmann, Müller, J., Schlarb, H., Schreiber, S., Schulz, S., Salen, P., Meulen, P., and Angelova Hamberg, G.

Abstract

For seeding of a free-electron laser, the spatial and temporal overlap of the seed laser pulse and the electron bunch in the modulator is critical. To establish the temporal overlap, the time difference between pulses from the seed laser and spontaneous undulator radiation is reduced to a few pico-seconds with a combination of a photomultiplier tube and a streak camera. Finally, for the precise overlap the impact of the seed laser pulses on the electron bunches is observed. In this contribution, we describe the current experimental setup, discuss the techniques applied to establish the temporal overlap and analyze its stability.

Published
2014

41. Demonstration of SASE Suppression Through a Seeded Microbunching Instability

Author

Lechnery, C., Azima, A., Drescher, M., Lazzarino, L. L., Maltezopoulos, Th, Miltchev, V., Plath, T., Rönsch-Schulenburg, J., Rossbach, J., Hacker, K. E., Khan, S., Molo, R., Ackermann, S., Bödewadt, J., Brenner, G., Dohlus, M., Ekanayake, N., Golz, T., Hass, E., Honkavaara, K., Tim Laarmann, Limberg, T., Schneidmiller, E., Stojanovic, N., and Yurkov, M.

Subjects
Physics::Accelerator Physics
Abstract

Collective effects and instabilities due to longitudinal space charge and coherent synchrotron radiation can degrade the quality of the ultra-relativistic, high-brightness electron bunches needed for the operation of free-electron lasers. In this contribution, we demonstrate the application of a laser-induced microbunching instability to selectively suppress the SASE process. A significant decrease of photon pulse energies was observed at the free-electron laser FLASH in coincidence with overlap of 800 nm laser pulses and electron bunches within a modulator located approximately 40 meters upstream of the undulators. We discuss the underlying mechanisms based on longitudinal space charge amplification [E.A. Schneidmiller and M.V. Yurkov, Phys. Rev. ST Accel. Beams 13, 110701 (2010)] and present measurements.

Published
2014

42. Developments for the CR Stochastic Cooling System

Author

Dimopoulou, C., Barker, D., Rossbach, J., Thorndahl, L., Böhm, R., Dolinska, M., Hettrich, R., Maier, W., Kelnhofer, M., Krieg, J., Menges, R., and Peschke, C.

Subjects
Physics
Abstract

GSI Scientific Report 2013 - GSI Report 2014-1

Published
2014
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43. Simultaneous operation of two soft x-ray free-electron lasers driven by one linear accelerator

Author

Faatz, B, primary, Plönjes, E, additional, Ackermann, S, additional, Agababyan, A, additional, Asgekar, V, additional, Ayvazyan, V, additional, Baark, S, additional, Baboi, N, additional, Balandin, V, additional, Bargen, N von, additional, Bican, Y, additional, Bilani, O, additional, Bödewadt, J, additional, Böhnert, M, additional, Böspflug, R, additional, Bonfigt, S, additional, Bolz, H, additional, Borges, F, additional, Borkenhagen, O, additional, Brachmanski, M, additional, Braune, M, additional, Brinkmann, A, additional, Brovko, O, additional, Bruns, T, additional, Castro, P, additional, Chen, J, additional, Czwalinna, M K, additional, Damker, H, additional, Decking, W, additional, Degenhardt, M, additional, Delfs, A, additional, Delfs, T, additional, Deng, H, additional, Dressel, M, additional, Duhme, H-T, additional, Düsterer, S, additional, Eckoldt, H, additional, Eislage, A, additional, Felber, M, additional, Feldhaus, J, additional, Gessler, P, additional, Gibau, M, additional, Golubeva, N, additional, Golz, T, additional, Gonschior, J, additional, Grebentsov, A, additional, Grecki, M, additional, Grün, C, additional, Grunewald, S, additional, Hacker, K, additional, Hänisch, L, additional, Hage, A, additional, Hans, T, additional, Hass, E, additional, Hauberg, A, additional, Hensler, O, additional, Hesse, M, additional, Heuck, K, additional, Hidvegi, A, additional, Holz, M, additional, Honkavaara, K, additional, Höppner, H, additional, Ignatenko, A, additional, Jäger, J, additional, Jastrow, U, additional, Kammering, R, additional, Karstensen, S, additional, Kaukher, A, additional, Kay, H, additional, Keil, B, additional, Klose, K, additional, Kocharyan, V, additional, Köpke, M, additional, Körfer, M, additional, Kook, W, additional, Krause, B, additional, Krebs, O, additional, Kreis, S, additional, Krivan, F, additional, Kuhlmann, J, additional, Kuhlmann, M, additional, Kube, G, additional, Laarmann, T, additional, Lechner, C, additional, Lederer, S, additional, Leuschner, A, additional, Liebertz, D, additional, Liebing, J, additional, Liedtke, A, additional, Lilje, L, additional, Limberg, T, additional, Lipka, D, additional, Liu, B, additional, Lorbeer, B, additional, Ludwig, K, additional, Mahn, H, additional, Marinkovic, G, additional, Martens, C, additional, Marutzky, F, additional, Maslocv, M, additional, Meissner, D, additional, Mildner, N, additional, Miltchev, V, additional, Molnar, S, additional, Mross, D, additional, Müller, F, additional, Neumann, R, additional, Neumann, P, additional, Nölle, D, additional, Obier, F, additional, Pelzer, M, additional, Peters, H-B, additional, Petersen, K, additional, Petrosyan, A, additional, Petrosyan, G, additional, Petrosyan, L, additional, Petrosyan, V, additional, Petrov, A, additional, Pfeiffer, S, additional, Piotrowski, A, additional, Pisarov, Z, additional, Plath, T, additional, Pototzki, P, additional, Prandolini, M J, additional, Prenting, J, additional, Priebe, G, additional, Racky, B, additional, Ramm, T, additional, Rehlich, K, additional, Riedel, R, additional, Roggli, M, additional, Röhling, M, additional, Rönsch-Schulenburg, J, additional, Rossbach, J, additional, Rybnikov, V, additional, Schäfer, J, additional, Schaffran, J, additional, Schlarb, H, additional, Schlesselmann, G, additional, Schlösser, M, additional, Schmid, P, additional, Schmidt, C, additional, Schmidt-Föhre, F, additional, Schmitz, M, additional, Schneidmiller, E, additional, Schöps, A, additional, Scholz, M, additional, Schreiber, S, additional, Schütt, K, additional, Schütz, U, additional, Schulte-Schrepping, H, additional, Schulz, M, additional, Shabunov, A, additional, Smirnov, P, additional, Sombrowski, E, additional, Sorokin, A, additional, Sparr, B, additional, Spengler, J, additional, Staack, M, additional, Stadler, M, additional, Stechmann, C, additional, Steffen, B, additional, Stojanovic, N, additional, Sychev, V, additional, Syresin, E, additional, Tanikawa, T, additional, Tavella, F, additional, Tesch, N, additional, Tiedtke, K, additional, Tischer, M, additional, Treusch, R, additional, Tripathi, S, additional, Vagin, P, additional, Vetrov, P, additional, Vilcins, S, additional, Vogt, M, additional, Wagner, A de Zubiaurre, additional, Wamsat, T, additional, Weddig, H, additional, Weichert, G, additional, Weigelt, H, additional, Wentowski, N, additional, Wiebers, C, additional, Wilksen, T, additional, Willner, A, additional, Wittenburg, K, additional, Wohlenberg, T, additional, Wortmann, J, additional, Wurth, W, additional, Yurkov, M, additional, Zagorodnov, I, additional, and Zemella, J, additional

Published
2016
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46. Ion Source Operation at the GSI Accelerator Facility

Author

Hollinger, R., Tinschert, K., Maimone, J., Ochs, K., Roßbach, J., Schäffer, P., Schäffer, S., Stork, S., Vierheller, C., Wesp, A., Zulauf, S., Pfister, J., Adonin, A., Berezov, R., Brühl, M., Gutermuth, B., Heymach, F., Lang, R., and Mäder, J.

Published
2013

47. Research and Development on ECR Ion Sources

Author

Tinschert, K., Lang, R., Mäder, J., Maimone, F., Roßbach, J., and Spädtke, P.

Subjects
Physics
Abstract

GSI Scientific Report 2013 - GSI Report 2014-1

Published
2013

48. Short SASE-FEL Pulses at FLASH

Author

Roensch-Schulenburg, Juliane, Hass, E., Schreiber, S., Steffen, B., Yan, M., Yurkov, M., Shneydmiller, Evgeny, Kuhl, A., Plath, T., Rehders, M., Rossbach, J., Brenner, Guenter, Gerth, C., Mavric, U., and Schlarb, H.

Abstract

FLASH is a high-gain free-electron laser (FEL) in thesoft x-ray range. This paper discusses the generation ofvery short FEL pulses in the Self-Amplified SpontaneousEmission (SASE) - mode without an external seeding signal.In the optimal case a SASE-FEL can be operated inthe so-called single-spike mode. At FLASH a new photoinjectorlaser has been commissioned, which allows thegeneration of shorter bunches with low bunch charge directlyat the photo-cathode. This shorter injector laser reducesthe required bunch compression for short pulses andthus allows a stable SASE performance with shorter pulses.First SASE performance using the new injector laser hasbeen demonstrated and electron bunch and FEL radiationproperties have been measured. These measurements arepresented and next steps towards single spike operation arediscussed.

Published
2013

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