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1. T-Large Granular Lymphocytic Leukemia with Hepatosplenic T-Cell Lymphoma? A Rare Case of Simultaneous Neoplastic T-Cell Clones Highlighted by Flow Cytometry and Review of Literature

Author

Rossana Libonati, Michela Soda, Teodora Statuto, Luciana Valvano, Fiorella D’Auria, Giovanni D’Arena, Giuseppe Pietrantuono, Oreste Villani, Giovanna Rosaria Mansueto, Simona D’Agostino, Massimo Dante Di Somma, Alessia Telesca, and Rocchina Vilella

Subjects
T-large granular lymphocytic leukemia, hepatosplenic t-cell lymphoma, mixed-phenotype, flow cytometry, clonality, Biology (General), QH301-705.5
Abstract

Lymphoproliferative diseases are a heterogeneous set of malignant clonal proliferations of lymphocytes. Despite well-established diagnostic criteria, the diagnosis remains difficult due to their variety in clinical presentation and immunophenotypic profile. Lymphoid T-cell disorders are less common than B-cell entities, and the lack of a clear immunophenotypic characteristic makes their identification hard. Flow cytometry turned out to be a useful tool in diagnosing T-cell disorders and to resolve complicated cases, especially if the number of analyzable neoplastic cells is small. We present a case of a 55-year-old man with simultaneous lymphoproliferative neoplastic T-cell clones, one αβ and the other γδ, identified and characterized by flow cytometry (FC), exploiting the variable expression intensity of specific markers. However, the patient’s rapid decline made it impossible to define a differential diagnosis in order to confirm the identity of the γδ clone, which remains uncertain. This case is added to the few other cases already documented in the literature, characterized by the co-existence of T-large granular lymphocytic leukemia (T-LGLL)-αβ and T-LGLL-γδ/Hepatosplenic T-cell lymphoma (HSTCL). Our case underlines the key role of sensitive diagnostic tools in the assessment of potential relationship between the diagnosis, prognosis, and treatment in the two pathologies.

Published
2024
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2. Influence of shading treatment on yield, morphological traits and phenolic profile of sweet basil (Ocimum basilicum L.)

Author

Donato Castronuovo, Pietro Picuno, Rossana Libonati, Luigi Milella, Patrícia Valentão, Paula B. Andrade, Immacolata Faraone, Daniela Russo, and Vincenzo Candido

Subjects
0106 biological sciences, 0301 basic medicine, food.ingredient, biology, Chemistry, Basilicum, Plastic film, Greenhouse, Sweet Basil, Horticulture, biology.organism_classification, Ocimum, 01 natural sciences, food.food, 03 medical and health sciences, 030104 developmental biology, food, Herb, Lamiaceae, Shading, 010606 plant biology & botany
Abstract

We investigated the roles of different shading strategies on plant growth, antioxidant activity and phenolic profile of sweet basil (Ocimum basilicum L.), a widely used herb with culinary and medicinal properties. Sweet basil plants were cultivated in a commercial multi-span tunnel-greenhouse covered with an EVAC plastic film, shaded from solar radiation in five different ways: n. 1, by calcium hydroxide whitening; n. 2, installing up - or n. 3, under - the greenhouse roof, a PE-HD white reflective net with 36% shading factor; n. 4, installing up - or n. 5, under - the greenhouse roof, a PE-HD white reflective net with 58% shading factor. The remaining part of the greenhouse (n. 6 - control) was unshaded. In each trial, yield traits, antioxidant activity and contents of phenolics of sweet basil plants were assessed to evaluate the influence of the shading strategy on these parameters. The antioxidant capacity was evaluated by using three different in vitro assays: DPPH scavenging activity, reducing power (FRAP) and lipid peroxidation inhibition (BCB). To compare the data obtained by the different chemical methods, the relative antioxidant capacity index (RACI) was calculated. The yield was highest in unshaded plants. The control trial, in which the incoming solar radiation was filtered only by the film which covers the greenhouse, showed the highest RACI value (0.98), indicating that the antioxidant capacity was probably influenced by higher light and temperature conditions. Phenolic quantification, determined by HPLC-DAD, enabled to observe a correlation between the antioxidant power and the identified metabolites.

Published
2019
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