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15,318 results on '"Ross, A. S."'

1. Resolving discrepancies in bang-time predictions for ICF experiments on the NIF: Insights from the Build-A-Hohlraum Campaign

Author

Swadling, G. F., Farmer, W. A., Chen, H., Aybar, N., Rubery, M. S., Schneider, M. B., Liedahl, D. A., Lemos, N. C., Tubman, E., Ross, J. S., Hinkel, D. E., Landen, O. L., Rosen, M. D., Newman, S. Rogers K., Yanagisawa, D., Roskopf, N., Vonhof, S., Aghaian, L., Mauldin, M., Reichelt, B. L., and Kunimune, J.

Subjects
Physics - Plasma Physics
Abstract

This study investigated discrepancies between measured and simulated x-ray drive in Inertial Confinement Fusion (ICF) hohlraums at the National Ignition Facility (NIF). Despite advances in radiation-hydrodynamic simulations, a consistent "drive deficit" remains. Experimentally measured ICF capsule bang-times are systematically 400-700 ps later than simulations predict. The Build-A-Hohlraum (BAH) campaign explored potential causes for this discrepancy by systematically varying hohlraum features, including laser entrance hole (LEH) windows, capsules, and gas fills. Overall, the agreement between simulated and experimental x-ray drive was found to be largely unaffected by these changes. The data allows us to exclude some hypotheses put forward to potentially explain the discrepancy. Errors in the local thermodynamic equilibrium (LTE) atomic modeling, errors in the modeling of LEH closure and errors due to a lack of plasma species mix physics in simulations are shown to be inconsistent with our measurements. Instead, the data supports the hypothesis that errors in NLTE emission modeling are a significant contributor to the discrepancy. X-ray emission in the 2 - 4 keV range is found to be approximately 30% lower than in simulations. This is accompanied by higher than predicted electron temperatures in the gold bubble region, pointing to errors in non-LTE modeling. Introducing an opacity multiplier of 0.87 on energy groups above 1.8 keV improves agreement with experimental data, reducing the bang-time discrepancy from 300 ps to 100 ps. These results underscore the need for refined NLTE opacity models to enhance the predictive power of hohlraum simulations.

Published
2025

2. Outcomes from a Workshop on a National Center for Quantum Education

Author

Barnes, Edwin, Bennett, Michael B., Boltasseva, Alexandra, Borish, Victoria, Brown, Bennett, Carr, Lincoln D., Ceballos, Russell R., Dukes, Faith, Easton, Emily W., Economou, Sophia E., Edwards, E. E., Finkelstein, Noah D., Fracchiolla, C., Franklin, Diana, Freericks, J. K., Goss, Valerie, Hannum, Mark, Holincheck, Nancy, Kelly, Angela M., Lanes, Olivia, Lewandowski, H. J., Matsler, Karen Jo, Mercurio, Emily, Montaño, Inès, Murdock, Maajida, Peltz, Kiera, Perron, Justin K., Richardson, Christopher J. K., Rosenberg, Jessica L., Ross, Richard S., Ryu, Minjung, Samuel, Raymond E., Schrode, Nicole, Schwamberger, Susan, Searles, Thomas A., Singh, Chandralekha, Tingle, Alexandra, and Zwickl, Benjamin M.

Subjects
Physics - Physics Education
Abstract

In response to numerous programs seeking to advance quantum education and workforce development in the United States, experts from academia, industry, government, and professional societies convened for a National Science Foundation-sponsored workshop in February 2024 to explore the benefits and challenges of establishing a national center for quantum education. Broadly, such a center would foster collaboration and build the infrastructure required to develop a diverse and quantum-ready workforce. The workshop discussions centered around how a center could uniquely address gaps in public, K-12, and undergraduate quantum information science and engineering (QISE) education. Specifically, the community identified activities that, through a center, could lead to an increase in student awareness of quantum careers, boost the number of educators trained in quantum-related subjects, strengthen pathways into quantum careers, enhance the understanding of the U.S. quantum workforce, and elevate public engagement with QISE. Core proposed activities for the center include professional development for educators, coordinated curriculum development and curation, expanded access to educational laboratory equipment, robust evaluation and assessment practices, network building, and enhanced public engagement with quantum science.

Published
2024

3. Correction: Comprehensive genomic profiling of ESR1, PIK3CA, AKT1, and PTEN in HR(+)HER2(−) metastatic breast cancer: prevalence along treatment course and predictive value for endocrine therapy resistance in real-world practice

Author

Bhave, Manali A., Quintanilha, Julia C. F., Tukachinsky, Hanna, Li, Gerald, Scott, Takara, Ross, Jeffrey S., Pasquina, Lincoln, Huang, Richard S. P., McArthur, Heather, Levy, Mia A., Graf, Ryon P., and Kalinsky, Kevin

Published
2024
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7. Pan-tumor validation of a NGS fraction-based MSI analysis as a predictor of response to Pembrolizumab

Author

Lin, Douglas I., Quintanilha, Julia C. F., Danziger, Natalie, Lang, Lixin, Levitan, Diane, Hayne, Cynthia, Hiemenz, Matthew C., Smith, David L., Albacker, Lee A., Leibowitz, Jeffrey, Mata, Douglas A., Decker, Brennan, Lakis, Sotirios, Patel, Nimesh R., Graf, Ryon P., Elvin, Julia A., Ross, Jeffrey S., Pattani, Varun, Huang, Richard S. P., and Wehn, Amy K.

Published
2024
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11. The impact of low-mode symmetry on inertial fusion energy output in the burning plasma state

Author

Ralph, J. E., Ross, J. S., Zylstra, A. B., Kritcher, A. L., Robey, H. F., Young, C. V., Hurricane, O. A., Pak, A., Callahan, D. A., Baker, K. L., Casey, D. T., Döppner, T., Divol, L., Hohenberger, M., Pape, S. Le, Patel, P. K., Tommasini, R., Ali, S. J., Amendt, P. A., Atherton, L. J., Bachmann, B., Bailey, D., Benedetti, L. R., Berzak Hopkins, L., Betti, R., Bhandarkar, S. D., Biener, J., Bionta, R. M., Birge, N. W., Bond, E. J., Bradley, D. K., Braun, T., Briggs, T. M., Bruhn, M. W., Celliers, P. M., Chang, B., Chapman, T., Chen, H., Choate, C., Christopherson, A. R., Clark, D. S., Crippen, J. W., Dewald, E. L., Dittrich, T. R., Edwards, M. J., Farmer, W. A., Field, J. E., Fittinghoff, D., Frenje, J., Gaffney, J., Gatu Johnson, M., Glenzer, S. H., Grim, G. P., Haan, S., Hahn, K. D., Hall, G. N., Hammel, B. A., Harte, J., Hartouni, E., Heebner, J. E., Hernandez, V. J., Herrmann, H. W., Herrmann, M. C., Hinkel, D. E., Ho, D. D., Holder, J. P., Hsing, W. W., Huang, H., Humbird, K. D., Izumi, N., Jarrott, L. C., Jeet, J., Jones, O., Kerbel, G. D., Kerr, S. M., Khan, S. F., Kilkenny, J., Kim, Y., Geppert-Kleinrath, H., Geppert-Kleinrath, V., Kong, C., Koning, J. M., Kroll, J. J., Kruse, M. K. G., Kustowski, B., Landen, O. L., Langer, S., Larson, D., Lemos, N. C., Lindl, J. D., Ma, T., MacDonald, M. J., MacGowan, B. J., Mackinnon, A. J., MacLaren, S. A., MacPhee, A. G., Marinak, M. M., Mariscal, D. A., Marley, E. V., Masse, L., Meaney, K. D., Meezan, N. B., Michel, P. A., Millot, M., Milovich, J. L., Moody, J. D., Moore, A. S., Morton, J. W., Murphy, T. J., Newman, K., Di Nicola, J.-M. G., Nikroo, A., Nora, R., Patel, M. V., Pelz, L. J., Peterson, J. L., Ping, Y., Pollock, B. B., Ratledge, M., Rice, N. G., Rinderknecht, H. G., Rosen, M., Rubery, M. S., Salmonson, J. D., Sater, J., Schiaffino, S., Schlossberg, D. J., Schneider, M. B., Schroeder, C. R., Scott, H. A., Sepke, S. M., Sequoia, K., Sherlock, M. W., Shin, S., Smalyuk, V. A., Spears, B. K., Springer, P. T., Stadermann, M., Stoupin, S., Strozzi, D. J., Suter, L. J., Thomas, C. A., Town, R. P. J., Trosseille, C., Tubman, E. R., Volegov, P. L., Weber, C. R., Widmann, K., Wild, C., Wilde, C. H., Van Wonterghem, B. M., Woods, D. T., Woodworth, B. N., Yamaguchi, M., Yang, S. T., and Zimmerman, G. B.

Published
2024
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13. Novel SOX10 indel mutations drive schwannomas through impaired transactivation of myelination gene programs

Author

Williams, Erik A, Ravindranathan, Ajay, Gupta, Rohit, Stevers, Nicholas O, Suwala, Abigail K, Hong, Chibo, Kim, Somang, Yuan, Jimmy Bo, Wu, Jasper, Barreto, Jairo, Lucas, Calixto-Hope G, Chan, Emily, Pekmezci, Melike, LeBoit, Philip E, Mully, Thaddeus, Perry, Arie, Bollen, Andrew, Van Ziffle, Jessica, Devine, W Patrick, Reddy, Alyssa T, Gupta, Nalin, Basnet, Kristen M, Macaulay, Robert JB, Malafronte, Patrick, Lee, Han, Yong, William H, Williams, Kevin Jon, Juratli, Tareq A, Mata, Douglas A, Huang, Richard SP, Hiemenz, Matthew C, Pavlick, Dean C, Frampton, Garrett M, Janovitz, Tyler, Ross, Jeffrey S, Chang, Susan M, Berger, Mitchel S, Jacques, Line, Song, Jun S, Costello, Joseph F, and Solomon, David A

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Cancer, Neurofibromatosis, Cancer Genomics, Genetics, Pediatric, Rare Diseases, Human Genome, Neurosciences, Biotechnology, 2.1 Biological and endogenous factors, Humans, INDEL Mutation, Transcriptional Activation, Neurilemmoma, Neuroma, Acoustic, Mutation, Nerve Sheath Neoplasms, SOXE Transcription Factors, myelination, PMP2, Schwann cell, schwannoma, SOX10, Oncology and Carcinogenesis, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundSchwannomas are common peripheral nerve sheath tumors that can cause severe morbidity given their stereotypic intracranial and paraspinal locations. Similar to many solid tumors, schwannomas and other nerve sheath tumors are primarily thought to arise due to aberrant hyperactivation of the RAS growth factor signaling pathway. Here, we sought to further define the molecular pathogenesis of schwannomas.MethodsWe performed comprehensive genomic profiling on a cohort of 96 human schwannomas, as well as DNA methylation profiling on a subset. Functional studies including RNA sequencing, chromatin immunoprecipitation-DNA sequencing, electrophoretic mobility shift assay, and luciferase reporter assays were performed in a fetal glial cell model following transduction with wildtype and tumor-derived mutant isoforms of SOX10.ResultsWe identified that nearly one-third of sporadic schwannomas lack alterations in known nerve sheath tumor genes and instead harbor novel recurrent in-frame insertion/deletion mutations in SOX10, which encodes a transcription factor responsible for controlling Schwann cell differentiation and myelination. SOX10 indel mutations were highly enriched in schwannomas arising from nonvestibular cranial nerves (eg facial, trigeminal, vagus) and were absent from vestibular nerve schwannomas driven by NF2 mutation. Functional studies revealed these SOX10 indel mutations have retained DNA binding capacity but impaired transactivation of glial differentiation and myelination gene programs.ConclusionsWe thus speculate that SOX10 indel mutations drive a unique subtype of schwannomas by impeding proper differentiation of immature Schwann cells.

Published
2023

15. US Postgraduate Trainee Racial, Ethnic, and Gender Representation and Faculty Compensation By Specialty

Author

Mensah, Michael O, Owda, Dalia, Simons, Efe C Ghanney, Holaday, Louisa W, Bonner, Sidra N, Mangurian, Christina, and Ross, Joseph S

Subjects
Biomedical and Clinical Sciences, Health Sciences, Minority Health, Humans, Faculty, Faculty, Medical, Medicine, Minority Groups, Racial Groups, United States, Sex Factors, Salaries and Fringe Benefits, Male, Female, Education, Medical, Graduate, Internship and Residency, Economics, Medical, Ethnicity, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

This study compares postgraduate trainee racial, ethnic, and gender representation and faculty compensation for 21 clinical specialties using 2015-2022 data.

Published
2023

22. First Results of NURE-Combo: A Phase II Study of Neoadjuvant Nivolumab and Nab-Paclitaxel, Followed by Postsurgical Adjuvant Nivolumab, for Muscle-Invasive Bladder Cancer

Author

Mercinelli, Chiara, Moschini, Marco, Cigliola, Antonio, Mattorre, Benedetta, Tateo, Valentina, Basile, Giuseppe, Cogrossi, Laura L., Maiorano, Brigida A., Patanè, Damiano A., Raggi, Daniele, Pastorino, Giovanni L., Re, Chiara, Colecchia, Maurizio, Lucianò, Roberta, Colombo, Renzo, Brembilla, Giorgio, De Cobelli, Francesco, Briganti, Alberto, Pavlick, Dean C., Ross, Jeffrey S., Montorsi, Francesco, Bellone, Matteo, and Necchi, Andrea

Published
2024
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24. Mismatch repair deficiency, next-generation sequencing-based microsatellite instability, and tumor mutational burden as predictive biomarkers for immune checkpoint inhibitor effectiveness in frontline treatment of advanced stage endometrial cancer

Author

Hill, Breana L, Graf, Ryon P, Shah, Kunal, Danziger, Natalie, Lin, Douglas I, Quintanilha, Julia, Li, Gerald, Haberberger, James, Ross, Jeffrey S, Santin, Alessandro D, Slomovitz, Brian, Elvin, Julia A, and Eskander, Ramez N

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Genetics, Digestive Diseases, Cancer, Clinical Trials and Supportive Activities, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Good Health and Well Being, Female, Humans, Biomarkers, Tumor, Colorectal Neoplasms, DNA Mismatch Repair, Endometrial Neoplasms, High-Throughput Nucleotide Sequencing, Immune Checkpoint Inhibitors, Microsatellite Instability, endometrium, uterine cancer, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract

ObjectiveMolecular profiling is developing to inform treatment in endometrial cancer. Using real world evidence, we sought to evaluate frontline immune checkpoint inhibitor vs chemotherapy effectiveness in advanced endometrial cancer, stratified by Tumor Mutational Burden (TMB) ≥10 mut/MB and microsatellite instability (MSI).MethodsPatients with advanced endometrial cancer in the US-based de-identified Flatiron Health-Foundation Medicine Clinico-Genomic Database were included. Data originated from patients treated between January 2011- March 2022 at 280 US clinics. Next-generation sequencing assays were performed via FoundationOne or FoundationOneCDx. Longitudinal clinical data were derived from electronic health records. Immune checkpoint inhibitor treatment included pembrolizumab, dostarlimab, and nivolumab monotherapies. Time to next treatment, time to treatment discontinuation, and overall survival were assessed with the log-rank test and Cox proportional hazard models with adjusted hazard ratios (aHR) for known prognostic factors. We used the Likelihood ratio test to compare biomarker performance.ResultsA total of 343 patients received chemotherapy and 28 received immune checkpoint inhibitor monotherapy as frontline treatment. Patients who received monotherapy were more likely to be stage III at diagnosis (immune checkpoint inhibitor: 54.6% vs chemotherapy: 15.0%; p

Published
2023

25. Europe’s Contribution to the Asian Balance of Power: Player or Observer?

Author

Ross, Robert S., Gu, Xuewu, Series Editor, Ohnesorge, Hendrik W., Managing Editor, Ikenberry, G. John, Advisory Editor, Jin, Canrong, Advisory Editor, Kondapalli, Srikanth, Advisory Editor, Neuss, Beate, Advisory Editor, Norrlof, Carla, Advisory Editor, Shen, Dingli, Advisory Editor, Togo, Kazuhiko, Advisory Editor, Zoboli, Roberto, Advisory Editor, and Biba, Sebastian, editor

Published
2024
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28. Bladder-sparing Therapy for Bacillus Calmette-Guérin–unresponsive Non–muscle-invasive Bladder Cancer: International Bladder Cancer Group Recommendations for Optimal Sequencing and Patient Selection

Author

Li, Roger, Hensley, Patrick J., Gupta, Shilpa, Al-Ahmadie, Hikmat, Babjuk, Marko, Black, Peter C., Brausi, Maurizio, Bree, Kelly K., Fernández, Mario I., Guo, Charles C., Horowitz, Amir, Lamm, Donald L., Lerner, Seth P., Lotan, Yair, Mariappan, Paramananthan, McConkey, David, Mertens, Laura S., Mir, Carmen, Ross, Jeffrey S., O’Donnell, Michael, Palou, Joan, Pohar, Kamal, Steinberg, Gary, Soloway, Mark, Spiess, Philippe E., Svatek, Robert S., Tan, Wei Shen, Taoka, Rikiya, Buckley, Roger, and Kamat, Ashish M.

Published
2024
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34. Recommended guidelines for screening for underlying malignancy in extramammary Paget's disease based on anatomic subtype

Author

Wang, Jake X., Harikumar, Vishnu, Downing, Malia B., Aasi, Sumaira Z., Aung, Phyu P., Barker, Christopher A., Bolotin, Diana, Bordeaux, Jeremy S., Cartee, Todd V., Chandra, Sunandana, Cho, Nancy L., Choi, Jennifer N., Chung, Kee Yang, Cliby, William A., Dorigo, Oliver, Eisen, Daniel B., Fujisawa, Yasuhiro, Golda, Nicholas, Halfdanarson, Thorvardur R., Iavazzo, Christos, Brian Jiang, Shang I., John, Esther M., Kanitakis, Jean, Keimig, Emily L., Khan, Ashraf, Linos, Eleni, Kim, John Y.S., Kuzel, Timothy M., Lawrence, Naomi, Leitao, Mario M., Jr., MacLean, Allan B., Maher, Ian A., Mittal, Bharat B., Nehal, Kishwer S., Ozog, David M., Pettaway, Curtis A., Rajan, Neil, Ross, Jeffrey S., Rossi, Anthony M., Servaes, Sabah, Solomon, Michael J., Thomas, Valencia D., Tolia, Maria, Voelzke, Bryan B., Waldman, Abigail, Wong, Michael K., Zhou, Youwen, Brackett, Alexandria, Poon, Emily, Ahmed, Areeba, Kibbi, Nour, Owen, Joshua L., Worley, Brandon, and Alam, Murad

Published
2025
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35. High-precision real-space simulation of electrostatically-confined few-electron states

Author

Anderson, Christopher R., Gyure, Mark F., Quinn, Sam, Pan, Andrew, Ross, Richard S., and Kiselev, Andrey A.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Quantum Physics
Abstract

In this paper we present a computational procedure that utilizes real-space grids to obtain high precision approximations of electrostatically confined few-electron states such as those that arise in gated semiconductor quantum dots. We use the Full Configuration Interaction (FCI) method with a continuously adapted orthonormal orbital basis to approximate the ground and excited states of such systems. We also introduce a benchmark problem based on a realistic analytical electrostatic potential for quantum dot devices. We show that our approach leads to highly precise computed energies and energy differences over a wide range of model parameters. The analytic definition of the benchmark allows for a collection of tests that are easily replicated, thus facilitating comparisons with other computational approaches., Comment: 8 pages, 4 figures

Published
2022
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41. Insensitivity of a turbulent laser-plasma dynamo to initial conditions

Author

Bott, A. F. A., Chen, L., Tzeferacos, P., Palmer, C. A. J., Bell, A. R., Bingham, R., Birkel, A., Froula, D. H., Katz, J., Kunz, M. W., Li, C. -K., Park, H-S., Petrasso, R., Ross, J. S., Reville, B., Ryu, D., Séguin, F. H., White, T. G., Schekochihin, A. A., Lamb, D. Q., and Gregori, G.

Subjects
Physics - Plasma Physics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

It has recently been demonstrated experimentally that a turbulent plasma created by the collision of two inhomogeneous, asymmetric, weakly magnetised laser-produced plasma jets can generate strong stochastic magnetic fields via the small-scale turbulent dynamo mechanism, provided the magnetic Reynolds number of the plasma is sufficiently large. In this paper, we compare such a plasma with one arising from two pre-magnetised plasma jets whose creation is identical save for the addition of a strong external magnetic field imposed by a pulsed magnetic field generator (`MIFEDS'). We investigate the differences between the two turbulent systems using a Thomson-scattering diagnostic, X-ray self-emission imaging and proton radiography. The Thomson-scattering spectra and X-ray images suggest that the presence of the external magnetic field has a limited effect on the plasma dynamics in the experiment. While the presence of the external magnetic field induces collimation of the flows in the colliding plasma jets and the initial strengths of the magnetic fields arising from the interaction between the colliding jets are significantly larger as a result of the external field, the energy and morphology of the stochastic magnetic fields post-amplification are indistinguishable. We conclude that, for turbulent laser-plasmas with super-critical magnetic Reynolds numbers, the dynamo-amplified magnetic fields are determined by the turbulent dynamics rather than the seed fields and modest changes in the initial flow dynamics of the plasma, a finding consistent with theoretical expectations and simulations of turbulent dynamos., Comment: 13 pages, 12 figures

Published
2022
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42. Experiments conducted in the burning plasma regime with inertial fusion implosions

Author

Ross, J. S., Ralph, J. E., Zylstra, A. B., Kritcher, A. L., Robey, H. F., Young, C. V., Hurricane, O. A., Callahan, D. A., Baker, K. L., Casey, D. T., Doeppner, T., Divol, L., Hohenberger, M., Pape, S. Le, Pak, A., Patel, P. K., Tommasini, R., Ali, S. J., Amendt, P. A., Atherton, L. J., Bachmann, B., Bailey, D., Benedetti, L. R., Hopkins, L. Berzak, Betti, R., Bhandarkar, S. D., Bionta, R. M., Birge, N. W., Bond, E. J., Bradley, D. K., Braun, T., Briggs, T. M., Bruhn, M. W., Celliers, P. M., Chang, B., Chapman, T., Chen, H., Choate, C., Christopherson, A. R., Clark, D. S., Crippen, J. W., Dewald, E. L., Dittrich, T. R., Edwards, M. J., Farmer, W. A., Field, J. E., Fittinghoff, D., Frenje, J., Gaffney, J., Johnson, M. Gatu, Glenzer, S. H., Grim, G. P., Haan, S., Hahn, K. D., Hall, G. N., Hammel, B. A., Harte, J., Hartouni, E., Heebner, J. E., Hernandez, V. J., Herrmann, H., Herrmann, M. C., Hinkel, D. E., Ho, D. D., Holder, J. P., Hsing, W. W., Huang, H., Humbird, K. D., Izumi, N., Jarrott, L. C., Jeet, J., Jones, O., Kerbel, G. D., Kerr, S. M., Khan, S. F., Kilkenny, J., Kim, Y., Kleinrath, H. Geppert, Kleinrath, V. Geppert, Kong, C., Koning, J. M., Kroll, J. J., Landen, O. L., Langer, S., Larson, D., Lemos, N. C., Lindl, J. D., Ma, T., MacDonald, M. J., MacGowan, B. J., Mackinnon, A. J., MacLaren, S. A., MacPhee, A. G., Marinak, M. M., Mariscal, D. A., Marley, E. V., Masse, L., Meaney, K., Meezan, N. B., Michel, P. A., Millot, M., Milovich, J. L., Moody, J. D., Moore, A. S., Morton, J. W., Murphy, T., Newman, K., Di Nicola, J. -M. G., Nikroo, A., Nora, R., Patel, M. V., Pelz, L. J., Peterson, J. L., Ping, Y., Pollock, B. B., Ratledge, M., Rice, N. G., Rinderknecht, H., Rosen, M., Rubery, M. S., Salmonson, J. D., Sater, J., Schiaffino, S., Schlossberg, D. J., Schneider, M. B., Schroeder, C. R., Scott, H. A., Sepke, S. M., Sequoia, K., Sherlock, M. W., Shin, S., Smalyuk, V. A., Spears, B. K., Springer, P. T., Stadermann, M., Stoupin, S., Strozzi, D. J., Suter, L. J., Thomas, C. A., Town, R. P. J., Tubman, E. R., Volegov, P. L., Weber, C. R., Widmann, K., Wild, C., Wilde, C. H., Van Wonterghem, B. M., Woods, D. T., Woodworth, B. N., Yamaguchi, M., Yang, S. T., and Zimmerman, G. B.

Subjects
Physics - Plasma Physics, High Energy Physics - Experiment
Abstract

An experimental program is currently underway at the National Ignition Facility (NIF) to compress deuterium and tritium (DT) fuel to densities and temperatures sufficient to achieve fusion and energy gain. The primary approach being investigated is indirect drive inertial confinement fusion (ICF), where a high-Z radiation cavity (a hohlraum) is heated by lasers, converting the incident energy into x-ray radiation which in turn drives the DT fuel filled capsule causing it to implode. Previous experiments reported DT fuel gain exceeding unity [O.A. Hurricane et al., Nature 506, 343 (2014)] and then exceeding the kinetic energy of the imploding fuel [S. Le Pape et al., Phys. Rev. Lett. 120, 245003 (2018)]. We report on recent experiments that have achieved record fusion neutron yields on NIF, greater than 100 kJ with momentary fusion powers exceeding 1PW, and have for the first time entered the burning plasma regime where fusion alpha-heating of the fuel exceeds the energy delivered to the fuel via compression. This was accomplished by increasing the size of the high-density carbon (HDC) capsule, increasing energy coupling, while controlling symmetry and implosion design parameters. Two tactics were successful in controlling the radiation flux symmetry and therefore the implosion symmetry: transferring energy between laser cones via plasma waves, and changing the shape of the hohlraum. In conducting these experiments, we controlled for known sources of degradation. Herein we show how these experiments were performed to produce record performance, and demonstrate the data fidelity leading us to conclude that these shots have entered the burning plasma regime.

Published
2021

45. Molecularly guided therapy versus chemotherapy after disease control in unfavourable cancer of unknown primary (CUPISCO): an open-label, randomised, phase 2 study

Author

Krämer, Alwin, Bochtler, Tilmann, Pauli, Chantal, Shiu, Kai-Keen, Cook, Natalie, de Menezes, Juliana Janoski, Pazo-Cid, Roberto A, Losa, Ferran, Robbrecht, Debbie GJ, Tomášek, Jiří, Arslan, Cagatay, Özgüroğlu, Mustafa, Stahl, Michael, Bigot, Frédéric, Kim, Sun Young, Naito, Yoichi, Italiano, Antoine, Chalabi, Nasséra, Durán-Pacheco, Gonzalo, Michaud, Chantal, Scarato, Jeremy, Thomas, Marlene, Ross, Jeffrey S, Moch, Holger, and Mileshkin, Linda

Published
2024
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49. Linear Bounds for Cycle-free Saturation Games

Author

English, Sean, Masařík, Tomáš, McCourt, Grace, Meger, Erin, Ross, Michael S., and Spiro, Sam

Subjects
Mathematics - Combinatorics, Computer Science - Discrete Mathematics, 05C57
Abstract

Given a family of graphs $\mathcal{F}$, we define the $\mathcal{F}$-saturation game as follows. Two players alternate adding edges to an initially empty graph on $n$ vertices, with the only constraint being that neither player can add an edge that creates a subgraph in $\mathcal{F}$. The game ends when no more edges can be added to the graph. One of the players wishes to end the game as quickly as possible, while the other wishes to prolong the game. We let $\textrm{sat}_g(n,\mathcal{F})$ denote the number of edges that are in the final graph when both players play optimally. In general there are very few non-trivial bounds on the order of magnitude of $\textrm{sat}_g(n,\mathcal{F})$. In this work, we find collections of infinite families of cycles $\mathcal{C}$ such that $\textrm{sat}_g(n,\mathcal{C})$ has linear growth rate., Comment: 18 pages, 2 figures

Published
2021
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50. Practical Physical Educator Tools for Evaluating and Using App Accessibility Features

Author

Ross, Samantha M., Ross, Anne S., Abrahamson, Kayla, and Wyant, James

Abstract

Students with disabilities may experience barriers to curriculum when inaccessible apps are incorporated into the classroom. To support physical educators, this report offers guidance on identifying (section I) and using (section II) app accessibility features within physical education classrooms. Example applications and resources are shared that will empower educators to evaluate and effectively integrate accessible apps within their own practice. A checklist and illustrative examples, FlipGrid & Padlet, provide physical educators with a practical approach to integrating apps that are high in accessibility features (e.g., closed captioning, alternative text for images, screen reader compatibility), create inclusive learning spaces (e.g., multi-modal participation options), and reduce barriers to curriculum and learning.

Published
2023
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