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2. The Species-Specific Acquisition and Diversification of a K1-like Family of Killer Toxins in Budding Yeasts of the Saccharomycotina

Author

Fredericks, Lance R., primary, Lee, Mark D., additional, Crabtree, Angela M., additional, Boyer, Josephine M., additional, Kizer, Emily A., additional, Taggart, Nathan T., additional, Roslund, Cooper R., additional, Hunter, Samuel S., additional, Kennedy, Courtney B., additional, Willmore, Cody G., additional, Tebbe, Nova M., additional, Harris, Jade S., additional, Brocke, Sarah N., additional, and Rowley, Paul A., additional

Published
2021
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5. Vaginal Isolates of Candida glabrataare Uniquely Susceptible to Ionophoric Killer Toxins Produced by Saccharomyces cerevisiae.

Author

Fredericks, Lance R., Lee, Mark D., Eckert, Hannah R., Li, Shunji, Shipley, Mason A., Roslund, Cooper R., Boikov, Dina A., Kizer, Emily A., Sobel, Jack D., and Rowley, Paul A.

Abstract

Compared to other species of Candidayeasts, the growth of Candida glabratawas inhibited by many different strains of Saccharomyceskiller yeasts. The ionophoric K1 and K2 killer toxins were broadly inhibitory to all clinical isolates of C. glabratafrom patients with recurrent vulvovaginal candidiasis, despite high levels of resistance to clinically relevant antifungal therapeutics.

Published
2021
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