Search

Your search keyword '"Rosewicz, S."' showing total 254 results
Start Over Author "Rosewicz, S."
254 results on '"Rosewicz, S."'

3. The oral multitarget tumour growth inhibitor, ZK 304709, inhibits growth of pancreatic neuroendocrine tumours in an orthotopic mouse model

Author

Scholz, A., Wagner, K., Welzel, M., Remlinger, F., Wiedermann, B., Siemeister, G., Rosewicz, S., and Detjen, K.M.

Subjects
Pancreatic tumors -- Development and progression, Pancreatic tumors -- Care and treatment, Pancreatic tumors -- Research, Growth factor receptors -- Research, Cancer -- Care and treatment, Cancer -- Research, Health
Published
2009

5. Autocrine growth inhibition by transforming growth factor β-1 (TGFβ-1) in human neuroendocrine tumour cells

Author

Wimmel, A, Wiedenmann, B, and Rosewicz, S

Subjects
Care and treatment, Physiological aspects, Research, Genetic aspects, Methods, Causes of, Health aspects, Apoptosis -- Genetic aspects -- Physiological aspects -- Methods -- Research -- Health aspects, Intestinal diseases -- Research -- Causes of -- Health aspects -- Care and treatment -- Genetic aspects, Immunoblotting -- Methods -- Health aspects -- Physiological aspects -- Research, Neuroendocrine tumors -- Health aspects -- Care and treatment -- Genetic aspects -- Research, Transforming growth factors -- Research -- Physiological aspects -- Health aspects -- Genetic aspects -- Methods, Cancer cells -- Genetic aspects -- Methods -- Research -- Health aspects -- Physiological aspects, Gastrointestinal diseases -- Research -- Causes of -- Health aspects -- Care and treatment -- Genetic aspects, Gene expression -- Physiological aspects -- Research -- Methods -- Genetic aspects -- Health aspects, Colorectal diseases -- Research -- Causes of -- Health aspects -- Care and treatment -- Genetic aspects
Abstract

Background and aim: The role of transforming growth factor β-1 (TGFI3-1) in neuroendocrine tumour biology is currently unknown. We therefore examined the expression and biological significance of TGFβ signalling components [...]

Published
2003

18. Vascular endothelial growth factor-D induces lymphangiogenesis and lymphatic metastasis in models of ductal pancreatic cancer

Author

Von Marschall, Z, Scholz, A, Stacker, SA, Achen, MG, Jackson, D, Alves, F, Schirner, M, Haberey, M, Thierauch, K, Wiedenmann, B, and Rosewicz, S

Abstract

The presence of lymphatic metastases is a strong indicator for poor prognosis in patients with ductal pancreatic cancer. In order to better understand the mechanisms controlling lymphatic growth and lymph node metastasis in human ductal pancreatic cancer, we analyzed the expression pattern of the vascular endothelial growth factor-D (VEGF-D), its receptor VEGF-receptor-3 (VEGFR-3) and the lymphatic endothelium-specific hyaluronan receptor LYVE-1 in a panel of 19 primary human ductal pancreatic tumors and 10 normal pancreas specimens. We further addressed the biological function of VEGF-D for induction of lymphatic metastasis in a nude mouse xenograft model using two human ductal pancreatic cancer cell lines with overexpression of VEGF-D. Compared to normal human pancreas, pancreatic cancer tissue showed overexpression of VEGF-D and VEGFR-3 in conjunction with a high lymphatic vascularization as determined by immunohistochemistry and in situ hybridization. Tumors derived from VEGF-D-overexpressing cells had a higher microvessel density compared to their mock-controls, as determined based on CD31 immunohistochemistry. Importantly, these tumors also revealed a significant induction of intra- and peritumoral lymphatics, as judged from immunohistochemical detection of LYVE-1 expression. This was associated with a significant increase in lymphatic vessel invasion by tumor cells and an increased rate of lymphatic metastases, as indicated by pan-cytokeratin reactive cells in lymph nodes. Our results suggest that VEGF-D plays a pivotal role in stimulating lymphangiogenesis and lymphatic metastasis in human ductal pancreatic cancer, and therefore represents a novel therapeutic target for this devastating disease.

Published
2016

21. Pankreasläsion unklarer Dignität? Ein prospektiv entwickelter diagnostischer Algorithmus

Author

Böhmig, M, primary, Koch, I, additional, Hintze, RE, additional, Veltzke-Schlieker, W, additional, Hoepffner, N, additional, Müller, HP, additional, Lopez-Hänninen, E, additional, Amthauer, H, additional, Ricke, J, additional, Hosten, N, additional, Langrehr, J, additional, Schink, T, additional, Wernecke, KD, additional, Felix, R, additional, Neuhaus, P, additional, Wiedenmann, B, additional, and Rosewicz, S, additional

Published
2015
Full Text
View/download PDF

26. Vascular endothelial growth factor-D induces lymphangiogenesis and lymphatic metastasis in models of ductal pancreatic cancer

Author

Von Marschall, Z, Scholz, A, Stacker, SA, Achen, MG, Jackson, DG, Alves, F, Schirner, M, Haberey, M, Thierauch, KH, Wiedenmann, B, and Rosewicz, S

Abstract

The presence of lymphatic metastases is a strong indicator for poor prognosis in patients with ductal pancreatic cancer. In order to better understand the mechanisms controlling lymphatic growth and lymph node metastasis in human ductal pancreatic cancer, we analyzed the expression pattern of the vascular endothelial growth factor-D (VEGF-D), its receptor VEGF-receptor-3 (VEGFR-3) and the lymphatic endothelium-specific hyaluronan receptor LYVE-1 in a panel of 19 primary human ductal pancreatic tumors and 10 normal pancreas specimens. We further addressed the biological function of VEGF-D for induction of lymphatic metastasis in a nude mouse xenograft model using two human ductal pancreatic cancer cell lines with overexpression of VEGF-D. Compared to normal human pancreas, pancreatic cancer tissue showed overexpression of VEGF-D and VEGFR-3 in conjunction with a high lymphatic vascularization as determined by immunohistochemistry and in situ hybridization. Tumors derived from VEGF-D-overexpressing cells had a higher microvessel density compared to their mock-controls, as determined based on CD31 immunohistochemistry. Importantly, these tumors also revealed a significant induction of intra- and peritumoral lymphatics, as judged from immunohistochemical detection of LYVE-1 expression. This was associated with a significant increase in lymphatic vessel invasion by tumor cells and an increased rate of lymphatic metastases, as indicated by pan-cytokeratin reactive cells in lymph nodes. Our results suggest that VEGF-D plays a pivotal role in stimulating lymphangiogenesis and lymphatic metastasis in human ductal pancreatic cancer, and therefore represents a novel therapeutic target for this devastating disease.

Published
2005

37. Vergleich verschiedener Konservierungslösungen in der Langzeitperfusion der Leber anhand klinisch-chemischer Parameter

Author

Neuhaus, P., Rosewicz, S., Meißner, Wassilios Georgios, Neuhaus, P., Rosewicz, S., and Meißner, Wassilios Georgios

Abstract

Seit der Einführung der University of Wisconsin (UW)-Lösung ist für die humane Lebertransplantation eine sichere Kaltkonservierung von 24 Stunden möglich. Ungeachtet dieser Verbesserung kann es postoperativ weiterhin zu schweren Leberfunktionsstörungen bis hin zum Transplantatversagen kommen. Die Leberfunktionsstörungen stehen in engem Zusammenhang mit der Qualität und der Dauer der Organkonservierung. Eine verbesserte Organkonservierung sollte deshalb eine höhere Funktionsrate nach Implantation und eine Verlängerung der sicheren Konservierungsdauer ermöglichen. Mit der Untersuchung sollte die Frage beantwortet werden, ob eine kontinuierliche Perfusion von Schweinelebern mit der UW-Lösung anstelle einer Standardkaltlagerung in UW-Lösung einen geringeren Konservierungsschaden nach sich zieht. Weiterhin sollte mit dem Ziel der Etablierung eines in-vitro-Modells geklärt werden, ob mit dem modifizierten Modell der extrakorporalen Perfusion nach P. Neuhaus neue Konservierungslösungen unter Einsparung von Versuchstieren getestet werden können. Vor diesem Hintergrund wurde in zwei weiteren Versuchsgruppen die kontinuierliche Kaltperfusion mit der Freie Universität (FU)- bzw. der HTK-Lösung durchgeführt. Der Konservierungsschaden der Leber wurde während der sich an die Kaltkonservierung anschließenden Warmperfusion mit Schweineblut in-vitro quantifiziert. Die Unterschiede zwischen der kontinuierlichen Perfusion und der Kaltlagerung waren signifikant, wobei eine geringere Serumkonzentration der Transaminasen in der UW-Gruppe mit einer höheren Gallesekretion, einem geringeren arteriellen Widerstand und einer geringeren Zunahme des Lebergewichts einherging. Die Ergebnisse der FU-Gruppe lassen im Vergleich mit der kontinuierlichen Perfusion mit UW-Lösung eine ähnliche Konservierungsgüte annehmen, während der Konservierungsschaden in der HTK-Gruppe signifikant stärker ausgeprägt war. Zusammenfassend erwies sich die kontinuierliche Kaltperfusion mit der UW-Lösung als das besser g, COMPARISON OF DIFFERENT PRESERVATION SOLUTIONS FOR LONG-TERM CONTINUOUS PERFUSION OF THE LIVER The introduction of the University of Wisconsin (UW) solution for liver preservation in 1988 allowed for the first time the extension of the safe cold storage time up to 24 hours. Nevertheless, severe organ dysfunction of the liver may still occur postoperatively, depending on the quality and the duration of organ preservation. Therefore, improved organ preservation should make possible a higher rate of immediate organ function after transplantation and the extension of the safe cold storage time avoiding any wastage of organs due to liver dysfunction. Our study aimed to investigate whether continuous perfusion of pig livers in comparison to simple cold storage with the UW solution results in improved preservation. Furthermore, we examined if our extracorporal perfusion system, modified by P. Neuhaus, would be suitable to test new preservation solutions before clinical use allowing the establishment of a new in-vitro model. Thus, livers were perfused continuously using the Free University (FU) solution and the Histidine Tryptophan Ketoglutarate (HTK) solution respectively and preservation was compared to the UW solution. The preservation injury was measured in-vitro during a subsequent warm perfusion of the organ with pig blood. Differences between continuous perfusion and simple cold storage were significant. Lower concentrations of the transaminases in the UW group were associated with a higher bile secretion, a lower arterial pressure and a lower increase of the liver weight. Results obtained for the FU group suggest a comparable quality of preservation compared to livers continuously perfused with UW solution, whereas the extent of the preservation injury was significantly higher in the HTK group. In conclusion, in our experimental design continuous perfusion with UW solution seems to be a better method for organ preservation suggesting that the clinical use of this te

Published
1999

45. Pancreatic carcinoma.

Author

Rosewicz S, Wiedenmann B, Rosewicz, S, and Wiedenmann, B

Published
1997

Catalog

Books, media, physical & digital resources
See catalog results