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Your search keyword '"Rosero Valencia, Diego Fernando"' showing total 5 results
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5 results on '"Rosero Valencia, Diego Fernando"'

1. Isolation of Nocuolin A and Synthesis of New Oxadiazine Derivatives. Design, Synthesis, Molecular Docking, Apoptotic Evaluation, and Cathepsin B Inhibition

Author

Tena Pérez, Víctor, primary, Apaza Ticona, Luis, additional, H. Cabanillas, Alfredo, additional, Maderuelo Corral, Santiago, additional, Rosero Valencia, Diego Fernando, additional, Quintana, Antera Martel, additional, Ortega Domenech, Montserrat, additional, and Rumbero Sánchez, Ángel, additional

Published
2023
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3. Anti-inflammatory activity of glycolipids isolated from cyanobacterium Nodularia harveyana.

Author

Tena Pérez, Víctor, Apaza Ticona, Luis, Cabanillas, Alfredo H., Maderuelo Corral, Santiago, Rosero Valencia, Diego Fernando, Quintana, Antera Martel, Ortega Domenech, Montserrat, and Rumbero Sánchez, Ángel

Subjects
GLYCOLIPIDS, GAS chromatography/Mass spectrometry (GC-MS), FRESH water
Abstract

Activity-guided fractionations from the freshwater cyanobacterium Nodularia harveyana led to the isolation of two monogalactosyldiacylglycerols (MGDG), two digalactosyldiacylglycerols (DGDG), two monoglucosyldiacylglycerols (MGlcDG) and 1-(O-hexose)-3,25-hexacosanediol (HG). Structures were elucidated by a combination of 1D and 2D NMR analysis, HRMS and GC-MS. The potential for inhibition against TNF-α and NF-κB production of these seven compounds was tested in THP-1 cells. All compounds showed activity, but compound 7 showed higher inhibitory activity of TNF-α and NF-κB, with IC50 of 4.88 ± 0.13 and 3.64 ± 0.45 μM, respectively. [ABSTRACT FROM AUTHOR]

Published
2021
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5. Cybastacines A and B: Antibiotic Sesterterpenes from a Nostocsp. Cyanobacterium

Author

Cabanillas, Alfredo H., Tena Pérez, Víctor, Maderuelo Corral, Santiago, Rosero Valencia, Diego Fernando, Martel Quintana, Antera, Ortega Doménech, Montserrat, and Rumbero Sánchez, Ángel

Abstract

Cybastacines A (1) and B (2) were discovered as a novel pentacyclic sesterterpenoid–alkaloid skeleton structure, with a guanidinium group. These molecules were isolated from a Nostocsp. cyanobacterium collected in the Canary Islands. Their structures were elucidated primarily by a combination of spectroscopic analyses and X-ray diffraction. These compounds showed antibiotic activities against several clinically relevant bacterial strains.

Published
2024
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