30 results on '"Rosenthal, Annika"'
Search Results
2. Measuring self-regulation in everyday life: Reliability and validity of smartphone-based experiments in alcohol use disorder
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Zech, Hilmar, Waltmann, Maria, Lee, Ying, Reichert, Markus, Bedder, Rachel L., Rutledge, Robb B., Deeken, Friederike, Wenzel, Julia, Wedemeyer, Friederike, Aguilera, Alvaro, Aslan, Acelya, Bach, Patrick, Bahr, Nadja S., Ebrahimi, Claudia, Fischbach, Pascale C., Ganz, Marvin, Garbusow, Maria, Großkopf, Charlotte M., Heigert, Marie, Hentschel, Angela, Belanger, Matthew, Karl, Damian, Pelz, Patricia, Pinger, Mathieu, Riemerschmid, Carlotta, Rosenthal, Annika, Steffen, Johannes, Strehle, Jens, Weiss, Franziska, Wieder, Gesine, Wieland, Alfred, Zaiser, Judith, Zimmermann, Sina, Liu, Shuyan, Goschke, Thomas, Walter, Henrik, Tost, Heike, Lenz, Bernd, Andoh, Jamila, Ebner-Priemer, Ulrich, Rapp, Michael A., Heinz, Andreas, Dolan, Ray, Smolka, Michael N., and Deserno, Lorenz
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- 2023
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3. Modifying Pavlovian-to-instrumental transfer by approach avoidance training in healthy subjects: a proof of concept study
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Rosenthal, Annika, Chen, Ke, Beck, Anne, and Romanczuk-Seiferth, Nina
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- 2023
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4. Reward Processing in Alcohol-Dependent Patients and First-Degree Relatives: Functional Brain Activity During Anticipation of Monetary Gains and Losses
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Musial, Milena P.M., Beck, Anne, Rosenthal, Annika, Charlet, Katrin, Bach, Patrick, Kiefer, Falk, Vollstädt-Klein, Sabine, Walter, Henrik, Heinz, Andreas, and Rothkirch, Marcus
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- 2023
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5. The Dopamine System in Mediating Alcohol Effects in Humans
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Beck, Anne, primary, Ebrahimi, Claudia, additional, Rosenthal, Annika, additional, Charlet, Katrin, additional, and Heinz, Andreas, additional
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- 2023
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6. Heartbeat perception is causally linked to frontal delta oscillations
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Haslacher, David, primary, Reber, Philipp, additional, Cavallo, Alessia, additional, Rosenthal, Annika, additional, Pangratz, Elisabeth, additional, Beck, Anne, additional, Romanczuk Seiferth, Nina, additional, Nikulin, Vadim, additional, Villringer, Arno, additional, and Soekadar, Surjo, additional
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- 2024
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7. Are psychotic-like experiences related to a discontinuation of cannabis consumption in young adults?
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Daedelow, Laura S., Banaschewski, Tobias, Berning, Moritz, Bokde, Arun L.W., Brühl, Rüdiger, Burke Quinlan, Erin, Curran, H. Valerie, Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Hardon, Anita, Kaminski, Jakob, Martinot, Jean-Luc, Paillère Martinot, Marie-Laure, Artiges, Eric, Murray, Hayley, Nees, Frauke, Oei, Nicole Y.L., Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Hohmann, Sarah, Millenet, Sabina, Rosenthal, Annika, Fröhner, Juliane H., Smolka, Michael N., Walter, Henrik, Whelan, Robert, Wiers, Reinout W., Schumann, Gunter, and Heinz, Andreas
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- 2021
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8. Mindfulness in Treatment Approaches for Addiction — Underlying Mechanisms and Future Directions
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Rosenthal, Annika, Levin, Michael E., Garland, Eric L., and Romanczuk-Seiferth, Nina
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- 2021
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9. Correlation of striatal dopamine D2/3 receptor availability with GABA level in the anterior cingulate cortex in healthy controls but not in alcohol‐dependent subjects and individuals at high risk: A multimodal magnetic resonance spectroscopy and positron emission tomography study
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Spitta, Gianna, Gleich, Tobias, Rosenthal, Annika, Schubert, Florian, Aydin, Semiha, Heinz, Andreas, Buchert, Ralph, and Gallinat, Jürgen
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DOPAMINE receptors ,NUCLEAR magnetic resonance spectroscopy ,POSITRON emission tomography ,EMISSION spectroscopy ,GABA receptors ,CINGULATE cortex - Abstract
Background: The association of impaired dopaminergic neurotransmission with the development and maintenance of alcohol use disorder is well known. More specifically, reduced dopamine D2/3 receptors in the striatum of subjects with alcohol dependence (AD) compared to healthy controls have been found in previous studies. Furthermore, alterations of gamma‐aminobutyric acid (GABA) and glutamate (Glu) levels in the anterior cingulate cortex (ACC) of AD subjects have been documented in several studies. However, the interaction between cortical Glu levels and striatal dopamine D2/3 receptors has not been investigated in AD thus far. Methods: This study investigated dopamine D2/3 receptor availability via 18F‐fallypride positron emission tomography (PET) and GABA as well as Glu levels via magnetic resonance spectroscopy (MRS) in 19 detoxified AD subjects, 18 healthy controls (low risk, LR) controls and 19 individuals at high risk (HR) for developing AD, carefully matched for sex, age and smoking status. Results: We found a significant negative correlation between GABA levels in the ACC and dopamine D2/3 receptor availability in the associative striatum of LR but not in AD or HR individuals. Contrary to our expectations, we did not observe a correlation between Glu concentrations in the ACC and striatal D2/3 receptor availability. Conclusions: The results may reflect potential regulatory cortical mechanisms on mesolimbic dopamine receptors and their disruption in AD and individuals at high risk, mirroring complex neurotransmitter interactions associated with the pathogenesis of addiction. This is the first study combining 18F‐fallypride PET and MRS in AD subjects and individuals at high risk. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Alkohol
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Beck, Anne, Rosenthal, Annika, Müller, Christian, Heinz, Andreas, Charlet, Katrin, von Heyden, Maximilian, editor, Jungaberle, Henrik, editor, and Majić, Tomislav, editor
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- 2018
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11. An explorative single-arm clinical study to assess craving in patients with alcohol use disorder using Virtual Reality exposure (CRAVE) - study protocol
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Lütt, Alva, primary, Tsamitros, Nikolaos, additional, Wolbers, Thomas, additional, Rosenthal, Annika, additional, Bröcker, Anna-Lena, additional, Schöneck, Robert, additional, Bermpohl, Felix, additional, Heinz, Andreas, additional, Beck, Anne, additional, and Gutwinski, Stefan, additional
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- 2023
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12. Effects of a brief mindfulness meditation practice on Pavlovian-to-instrumental transfer in alcohol use disorder – a pilot study
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Rosenthal, Annika, primary, Garbusow, Maria, additional, Romanczuk-Seiferth, Nina, additional, and Beck, Anne, additional
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- 2023
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13. Effects of a Brief Mindfulness-Based Intervention on Pavlovian-To-Instrumental Transfer in Alcohol Use Disorder
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Rosenthal, Annika, primary, Garbusow, Maria, additional, Romanczuk-Seiferth, Nina, additional, and Beck, Anne, additional
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- 2023
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14. Alkohol
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Beck, Anne, primary, Rosenthal, Annika, additional, Müller, Christian, additional, Heinz, Andreas, additional, and Charlet, Katrin, additional
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- 2017
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15. Distinct dynamic behavioural response to social exclusion in male patients with a history of alcohol dependence.
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Chen, Ke, Wüstenberg, Torsten, Stiglbauer, Victoria, El‐Ahmad, Linda, Rosenthal, Annika, Pelz, Patricia, Gold, Stefan M., Heinz, Andreas, and Sebold, Miriam
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SOCIAL marginality ,ALCOHOLISM ,SOCIETAL reaction ,ALCOHOL drinking ,INTERLEUKIN-1 - Abstract
Social exclusion contributes to alcohol consumption, whereas the development of alcohol dependence (AD) can in turn lead to the social exclusion of people with AD. Previous research observed altered neural responses to experimentally induced social exclusion (i.e., Cyberball game) in patients with AD. In addition, inflammation has been associated with both social behaviours and AD. Our study aimed to investigate the dynamic behavioural response and the inflammatory effects of social exclusion in male patients with a history of AD. To this end, we analysed dynamic changes in ball tossing during a partial exclusion Cyberball game and the cytokine interleukin (IL)‐1b in saliva in 31 male patients who had a history of AD and 29 gender‐matched healthy controls without AD. Participants were included in the first 2 min of the Cyberball game and then excluded by one of the two co‐players in the proceeding 5 min. Saliva was collected three times: one before and two after the Cyberball game. Across groups, participants passed the ball more often to the excluder during the partial exclusion period. Analysis using piece‐wise linear mixed models showed that patients rapidly increased ball tosses to the excluder upon exclusion, which lasted to the late response phase, whereas the early behavioural response to exclusion took longer for controls. There was no significant change of salivary IL‐1b level to exclusion in either patients or controls. The results indicate a distinct dynamic behavioural response to social exclusion in male patients with a history of AD. [ABSTRACT FROM AUTHOR]
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- 2023
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16. Effects of a brief mindfulness meditation practice on Pavlovian-toinstrumental transfer in alcohol use disorder - a pilot study.
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Rosenthal, Annika, Garbusow, Maria, Romanczuk-Seiferth, Nina, and Beck, Anne
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ALCOHOLISM ,MINDFULNESS ,MEDITATION ,PILOT projects - Abstract
Introduction: Pavlovian conditioned contextual cues have been suggested to modulate instrumental action and might explain maladaptive behavior such as relapse in participants suffering from alcohol use disorder (AUD). Pavlovian-to-Instrumental transfer (PIT) experimentally assesses the magnitude of this contextdependent effect and studies have shown a larger PIT effect in AUD populations. Taken this into account, a reduction of the influence of cues on behavior seems warranted and one approach that could alter such cue reactivity is mindfulness. Mindfulness-based interventions have been shown to be efficient in the treatment of AUD, but underlying mechanisms are yet to be elucidated. Therefore, we aim at investigating the effect of a brief mindful body scan meditation on the magnitude of the PIT effect in AUD subjects and matched controls. Methods: Using a randomized within-subjects design, we compared the effect of a short audio guided body scan meditation against a control condition (audio of nature sounds) on PIT in healthy (n = 35) and AUD (n = 27) participants. Results: We found no differences in PIT effect between healthy and AUD participants as well as between conditions. However, a significant interaction effect points to a decreased PIT effect after body scan meditation in AUD subjects only. Discussion: These pilot results suggest that AUD might be susceptible to mindfulness-induced changes in PIT, with these findings contributing to entangling the underlying mechanisms of the efficacy of mindfulness-based interventions in AUD. However, further investigation should confirm these preliminary results and the efficacy of mindfulness meditation practice in decreasing the PIT effect. [ABSTRACT FROM AUTHOR]
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- 2023
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17. Measuring self-regulation in everyday life: reliability and validity of smartphone-based experiments in alcohol use disorder
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Zech, Hilmar G, primary, Waltmann, Maria, additional, Lee, Ying, additional, Reichert, Markus, additional, Bedder, Rachel, additional, Rutledge, Robb, additional, Deeken, Friederike, additional, Wenzel, Julia, additional, Wedemeyer, Friederike, additional, Aguilera, Alvaro, additional, Aslan, Acelya, additional, Bach, Patrick, additional, Bahr, Nadja Samia, additional, Ebrahimi, Claudia, additional, Fischbach, Pascale C., additional, Ganz, Marvin, additional, Garbusow, Maria, additional, Großkopf, Charlotte M., additional, Heigert, Marie, additional, Hentschel, Angela, additional, Belanger, Matthew Joseph, additional, Karln, Damian, additional, Pelz, Patricia, additional, Pinger, Mathieu, additional, Riemerschmid, Carlotta, additional, Rosenthal, Annika, additional, Steffen, Johannes, additional, Strehle, Jens, additional, Weiss, Franziska, additional, Wieder, Gesine, additional, Wieland, Alfred, additional, Zaiser, Judith, additional, Zimmermann, Sina, additional, Liu, Shuyan, additional, Walter, Henrik, additional, Tost, Heike, additional, Lenz, Bernd, additional, Andoh, Jamila, additional, Ebner-Priemer, Ulrich, additional, rapp, michael, additional, Heinz, Andreas, additional, Dolan, Raymond J, additional, Smolka, Michael N., additional, and Deserno, Lorenz, additional
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- 2022
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18. Modifying Pavlovian-To-Instrumental Transfer By Approach Avoidance Training In Healthy Subjects – A Proof of Concept Study
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Rosenthal, Annika, primary, Chen, Ke, additional, Beck, Anne, additional, and Romanczuk-Seiferth, Nina, additional
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- 2022
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19. Reward Processing in Alcohol-Dependent Patients and First-Degree Relatives: Functional Brain Activity During Anticipation of Monetary Gains and Losses
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Musial, Milena P.M., primary, Beck, Anne, additional, Rosenthal, Annika, additional, Charlet, Katrin, additional, Bach, Patrick, additional, Kiefer, Falk, additional, Vollstädt-Klein, Sabine, additional, Walter, Henrik, additional, Heinz, Andreas, additional, and Rothkirch, Marcus, additional
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- 2022
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20. Measuring self-regulation in everyday life: Reliability and validity of smartphone-based experiments in alcohol use disorder
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Zech, Hilmar, Waltmann, Maria, Lee, Ying, Reichert, Markus, Bedder, Rachel L., Rutledge, Robb B., Deeken, Friederike, Wenzel, Julia, Wedemeyer, Friederike, Aguilera, Alvaro, Aslan, Acelya, Bach, Patrick, Bahr, Nadja S., Ebrahimi, Claudia, Fischbach, Pascale C., Ganz, Marvin, Garbusow, Maria, Großkopf, Charlotte M., Heigert, Marie, Hentschel, Angela, Belanger, Matthew, Karl, Damian, Pelz, Patricia, Pinger, Mathieu, Riemerschmid, Carlotta, Rosenthal, Annika, Steffen, Johannes, Strehle, Jens, Weiss, Franziska, Wieder, Gesine, Wieland, Alfred, Zaiser, Judith, Zimmermann, Sina, Liu, Shuyan, Goschke, Thomas, Walter, Henrik, Tost, Heike, Lenz, Bernd, Andoh, Jamila, Ebner-Priemer, Ulrich, Rapp, Michael A., Heinz, Andreas, Dolan, Ray, Smolka, Michael N., Deserno, Lorenz, Zech, Hilmar, Waltmann, Maria, Lee, Ying, Reichert, Markus, Bedder, Rachel L., Rutledge, Robb B., Deeken, Friederike, Wenzel, Julia, Wedemeyer, Friederike, Aguilera, Alvaro, Aslan, Acelya, Bach, Patrick, Bahr, Nadja S., Ebrahimi, Claudia, Fischbach, Pascale C., Ganz, Marvin, Garbusow, Maria, Großkopf, Charlotte M., Heigert, Marie, Hentschel, Angela, Belanger, Matthew, Karl, Damian, Pelz, Patricia, Pinger, Mathieu, Riemerschmid, Carlotta, Rosenthal, Annika, Steffen, Johannes, Strehle, Jens, Weiss, Franziska, Wieder, Gesine, Wieland, Alfred, Zaiser, Judith, Zimmermann, Sina, Liu, Shuyan, Goschke, Thomas, Walter, Henrik, Tost, Heike, Lenz, Bernd, Andoh, Jamila, Ebner-Priemer, Ulrich, Rapp, Michael A., Heinz, Andreas, Dolan, Ray, Smolka, Michael N., and Deserno, Lorenz
- Abstract
Self-regulation, the ability to guide behavior according to one’s goals, plays an integral role in understanding loss of control over unwanted behaviors, for example in alcohol use disorder (AUD). Yet, experimental tasks that measure processes underlying self-regulation are not easy to deploy in contexts where such behaviors usually occur, namely outside the laboratory, and in clinical populations such as people with AUD. Moreover, lab-based tasks have been criticized for poor test–retest reliability and lack of construct validity. Smartphones can be used to deploy tasks in the field, but often require shorter versions of tasks, which may further decrease reliability. Here, we show that combining smartphone-based tasks with joint hierarchical modeling of longitudinal data can overcome at least some of these shortcomings. We test four short smartphone-based tasks outside the laboratory in a large sample (N = 488) of participants with AUD. Although task measures indeed have low reliability when data are analyzed traditionally by modeling each session separately, joint modeling of longitudinal data increases reliability to good and oftentimes excellent levels. We next test the measures’ construct validity and show that extracted latent factors are indeed in line with theoretical accounts of cognitive control and decision-making. Finally, we demonstrate that a resulting cognitive control factor relates to a real-life measure of drinking behavior and yields stronger correlations than single measures based on traditional analyses. Our findings demonstrate how short, smartphone-based task measures, when analyzed with joint hierarchical modeling and latent factor analysis, can overcome frequently reported shortcomings of experimental tasks.
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- 2022
21. Patterns of Alcohol Consumption Among Individuals With Alcohol Use Disorder During the COVID-19 Pandemic and Lockdowns in Germany
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ReCoDe Consortium, Deeken, Friederike, Reichert, Markus, Zech, Hilmar, Wenzel, Julia, Wedemeyer, Friederike, Aguilera, Alvaro, Aslan, Acelya, Bach, Patrick, Bahr, Nadja S., Ebrahimi, Claudia, Fischbach, Pascale C., Ganz, Marvin, Garbusow, Maria, Großkopf, Charlotte M., Heigert, Marie, Hentschel, Angela, Karl, Damian, Pelz, Patricia, Pinger, Mathieu, Riemerschmid, Carlotta, Rosenthal, Annika, Steffen, Johannes, Strehle, Jens, Weiss, Franziska, Wieder, Gesine, Wieland, Alfred, Zaiser, Judith, Zimmermann, Sina, Walter, Henrik, Lenz, Bernd, Deserno, Lorenz, Smolka, Michael N., Liu, Shuyan, Ebner-Priemer, Ulrich W., Heinz, Andreas, Rapp, Michael A., Romanczuk-Seiferth, Nina, Ströhle, Andreas, Bermpohl, Felix, Heim, Christine, Beck, Anne, Tost, Heike, Banaschewski, Tobias, Kiefer, Falk, Meyer-Lindenberg, Andreas, Beste, Christian, Endraß, Tanja, Kiebel, Stefan, Kirschbaum, Clemens, Marxen, Michael, Nagel, Wolfgang E., Pilhatsch, Maximilian, Stock, Ann-Kathrin, Arndt, Viktoria, Belanger, Matthew, Chen, Hao, Frölich, Sasha, Ghin, Filippo, Neumer, Caroline, Schwöbel, Sarah, Gan, Gabriela, Schwarz, Kristina, Kunas, Stefanie, Stuke, Heiner, and ReCoDe Consortium
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Adult ,Male ,Alcohol Drinking ,COVID-19 ,General Medicine ,Substance Withdrawal Syndrome ,Extern ,Strukturbereich Kognitionswissenschaften ,Cohort Studies ,Alcoholism ,Athletic & outdoor sports & games ,Germany ,Communicable Disease Control ,Humans ,Female ,Longitudinal Studies ,ddc:610 ,ddc:796 ,610 Medizin und Gesundheit ,Pandemics - Abstract
Importance Alcohol consumption (AC) leads to death and disability worldwide. Ongoing discussions on potential negative effects of the COVID-19 pandemic on AC need to be informed by real-world evidence. Objective To examine whether lockdown measures are associated with AC and consumption-related temporal and psychological within-person mechanisms. Design, Setting, and Participants This quantitative, intensive, longitudinal cohort study recruited 1743 participants from 3 sites from February 20, 2020, to February 28, 2021. Data were provided before and within the second lockdown of the COVID-19 pandemic in Germany: before lockdown (October 2 to November 1, 2020); light lockdown (November 2 to December 15, 2020); and hard lockdown (December 16, 2020, to February 28, 2021). Main Outcomes and Measures Daily ratings of AC (main outcome) captured during 3 lockdown phases (main variable) and temporal (weekends and holidays) and psychological (social isolation and drinking intention) correlates. Results Of the 1743 screened participants, 189 (119 [63.0%] male; median [IQR] age, 37 [27.5-52.0] years) with at least 2 alcohol use disorder (AUD) criteria according to the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) yet without the need for medically supervised alcohol withdrawal were included. These individuals provided 14 694 smartphone ratings from October 2020 through February 2021. Multilevel modeling revealed significantly higher AC (grams of alcohol per day) on weekend days vs weekdays (β = 11.39; 95% CI, 10.00-12.77; P < .001). Alcohol consumption was above the overall average on Christmas (β = 26.82; 95% CI, 21.87-31.77; P < .001) and New Year’s Eve (β = 66.88; 95% CI, 59.22-74.54; P < .001). During the hard lockdown, perceived social isolation was significantly higher (β = 0.12; 95% CI, 0.06-0.15; P < .001), but AC was significantly lower (β = −5.45; 95% CI, −8.00 to −2.90; P = .001). Independent of lockdown, intention to drink less alcohol was associated with lower AC (β = −11.10; 95% CI, −13.63 to −8.58; P < .001). Notably, differences in AC between weekend and weekdays decreased both during the hard lockdown (β = −6.14; 95% CI, −9.96 to −2.31; P = .002) and in participants with severe AUD (β = −6.26; 95% CI, −10.18 to −2.34; P = .002). Conclusions and Relevance This 5-month cohort study found no immediate negative associations of lockdown measures with overall AC. Rather, weekend-weekday and holiday AC patterns exceeded lockdown effects. Differences in AC between weekend days and weekdays evinced that weekend drinking cycles decreased as a function of AUD severity and lockdown measures, indicating a potential mechanism of losing and regaining control. This finding suggests that temporal patterns and drinking intention constitute promising targets for prevention and intervention, even in high-risk individuals., Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe; 805
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- 2022
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22. The Treatment of Substance Use Disorders: Recent Developments and New Perspectives
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Rosenthal, Annika, primary, Ebrahimi, Claudia, additional, Wedemeyer, Friederike, additional, Romanczuk-Seiferth, Nina, additional, and Beck, Anne, additional
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- 2022
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23. The IMAGEN study: a decade of imaging genetics in adolescents
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Mascarell Maričić, Lea, Walter, Henrik, Rosenthal, Annika, Ripke, Stephan, Quinlan, Erin Burke, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L. W., Bromberg, Uli, Büchel, Christian, Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Garavan, Hugh, Itterman, Bernd, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Poustka, Luise, Hohmann, Sarah, Smolka, Michael N., Fröhner, Juliane H., Whelan, Robert, Kaminski, Jakob, Schumann, Gunter, Heinz, Andreas, Albrecht, Lisa, Andrew, Chris, Arroyo, Mercedes, Artiges, Eric, Aydin, Semiha, Bach, Christine, Barbot, Alexis, Barker, Gareth, Boddaert, Nathalie, Bokde, Arun, Bricaud, Zuleima, Bruehl, Ruediger, Cachia, Arnaud, Cattrell, Anna, Conrod, Patricia, Constant, Patrick, Dalley, Jeffrey, Decideur, Benjamin, Desrivieres, Sylvane, Fadai, Tahmine, Gallinat, Jürgen, Briand, Fanny Gollier, Gowland, Penny, Heinrichs, Bert, Heym, Nadja, Hübner, Thomas, Ireland, James, Ittermann, Bernd, Jia, Tianye, Lathrop, Mark, Lanzerath, Dirk, Lawrence, Claire, Lemaitre, Hervé, Lüdemann, Katharina, Macare, Christine, Mallik, Catherine, Mangin, Jean-François, Mann, Karl, Mennigen, Eva, de Carvahlo, Fabiana Mesquita, Mignon, Xavier, Miranda, Ruben, Müller, Kathrin, Nymberg, Charlotte, Paillere, Marie-Laure, Paus, Tomas, Pausova, Zdenka, Poline, Jean-Baptiste, Rapp, Michael, Robert, Gabriel, Reuter, Jan, Rietschel, Marcella, Robbins, Trevor, Rodehacke, Sarah, Rogers, John, Romanowski, Alexander, Ruggeri, Barbara, Schmäl, Christine, Schmidt, Dirk, Schneider, Sophia, Schumann, MarkGunter, Schubert, Florian, Schwartz, Yannick, Smolka, Michael, Sommer, Wolfgang, Spanagel, Rainer, Speiser, Claudia, Spranger, Tade, Stedman, Alicia, Steiner, Sabina, Stephens, Dai, Strache, Nicole, Ströhle, Andreas, Struve, Maren, Subramaniam, Naresh, Topper, Lauren, Williams, Steve, Yacubian, Juliana, Zilbovicius, Monica, Wong, C. Peng, Lubbe, Steven, Martinez-Medina, Lourdes, Fernandes, Alinda, and Tahmasebi, Amir
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Time Factors ,Adolescent ,Imaging genetics ,Brain Structure and Function ,Neuroimaging ,Cohort Studies ,Cellular and Molecular Neuroscience ,Reward ,Genetics ,Humans ,Psychology ,Multicenter Studies as Topic ,Generalizability theory ,Molecular Biology ,Reproducibility of Results ,Small sample ,Anticipation ,Psychiatry and Mental health ,Sample size determination ,Adolescent Behavior ,Cohort ,Brain size ,Perspective ,600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit ,Clinical psychology ,Neuroscience - Abstract
Imaging genetics offers the possibility of detecting associations between genotype and brain structure as well as function, with effect sizes potentially exceeding correlations between genotype and behavior. However, study results are often limited due to small sample sizes and methodological differences, thus reducing the reliability of findings. The IMAGEN cohort with 2000 young adolescents assessed from the age of 14 onwards tries to eliminate some of these limitations by offering a longitudinal approach and sufficient sample size for analyzing gene-environment interactions on brain structure and function. Here, we give a systematic review of IMAGEN publications since the start of the consortium. We then focus on the specific phenotype ‘drug use’ to illustrate the potential of the IMAGEN approach. We describe findings with respect to frontocortical, limbic and striatal brain volume, functional activation elicited by reward anticipation, behavioral inhibition, and affective faces, and their respective associations with drug intake. In addition to describing its strengths, we also discuss limitations of the IMAGEN study. Because of the longitudinal design and related attrition, analyses are underpowered for (epi-) genome-wide approaches due to the limited sample size. Estimating the generalizability of results requires replications in independent samples. However, such densely phenotyped longitudinal studies are still rare and alternative internal cross-validation methods (e.g., leave-one out, split-half) are also warranted. In conclusion, the IMAGEN cohort is a unique, very well characterized longitudinal sample, which helped to elucidate neurobiological mechanisms involved in complex behavior and offers the possibility to further disentangle genotype × phenotype interactions.
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- 2020
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24. Volumetric Prefrontal Cortex Alterations in Patients With Alcohol Dependence and the Involvement of Self‐Control
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Rosenthal, Annika, primary, Beck, Anne, additional, Zois, Evangelos, additional, Vollstädt‐Klein, Sabine, additional, Walter, Henrik, additional, Kiefer, Falk, additional, Lohoff, Falk W., additional, and Charlet, Katrin, additional
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- 2019
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25. Imaging resilience and recovery in alcohol dependence
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Charlet, Katrin, primary, Rosenthal, Annika, additional, Lohoff, Falk W., additional, Heinz, Andreas, additional, and Beck, Anne, additional
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- 2018
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26. Anticraving and Beyond – Innovative Therapieansätze in der Suchtbehandlung
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Heinz, Andreas, additional, Daedelow, Laura, additional, Mascarell-Maricic, Lea, additional, and Rosenthal, Annika, additional
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- 2017
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27. Kulturen der Menschheit: Woher und wohin? Transdisziplinäre Perspektiven unserer Vergangenheit.
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ROSENTHAL, ANNIKA
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- 2017
28. Associations of Menstrual Cycle and Progesterone-to-Estradiol Ratio With Alcohol Consumption in Alcohol Use Disorder: A Sex-Separated Multicenter Longitudinal Study.
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Hoffmann S, Gerhardt S, Mühle C, Reinhard I, Reichert D, Bach P, Boroumand-Jazi R, Kuehner C, Aguilera A, Aslan A, Bahr NS, Belanger M, Deeken F, Ebrahimi C, Fischbach PC, Ganz M, Garbusow M, Großkopf CM, Heigert M, Hentschel A, Karl D, Liu S, Mazza M, Pelz P, Pinger M, Reichl M, Riemerschmid C, Rosenthal A, Steffen J, Strehle J, Wedemeyer F, Weiss F, Wenzel J, Wieder G, Wieland A, Zaiser J, Zech HG, Zimmermann S, Kornhuber J, Müller CP, Sommer WH, Spanagel R, Banaschewski T, Deserno L, Ebner-Priemer UW, Flor H, Kirsch P, Rietschel M, Vollstädt-Klein S, Walter H, Meyer-Lindenberg A, Rapp MA, Witt S, Smolka MN, Heinz A, Tost H, Kiefer F, Reichert M, and Lenz B
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- Humans, Female, Male, Adult, Longitudinal Studies, Binge Drinking blood, Binge Drinking epidemiology, Sex Factors, Middle Aged, Young Adult, Estradiol blood, Progesterone blood, Menstrual Cycle blood, Alcoholism blood, Alcoholism epidemiology, Alcohol Drinking blood, Alcohol Drinking epidemiology
- Abstract
Objective: Alcohol use disorder (AUD) constitutes a critical public health issue and has sex-specific characteristics. Initial evidence suggests that progesterone and estradiol might reduce or increase alcohol intake, respectively. However, there is a need for a better understanding of how the menstrual cycle in females and the ratio of progesterone to estradiol in females and males influence alcohol use patterns in individuals with AUD., Methods: In this sex-separated multicenter longitudinal study, the authors analyzed 12-month data on real-life alcohol use (from 21,460 smartphone entries), menstrual cycle, and serum progesterone-to-estradiol ratios (from 667 blood samples at four individual study visits) in 74 naturally cycling females and 278 males with AUD between 2020 and 2022, using generalized and general linear mixed modeling., Results: Menstrual cycle phases were significantly associated with binge drinking and progesterone-to-estradiol ratio. During the late luteal phase, females showed a lower predicted binge drinking probability of 13% and a higher predicted marginal mean of progesterone-to-estradiol ratio of 95 compared with during the menstrual, follicular, and ovulatory phases (binge drinking probability and odds ratios vs. late luteal phase, respectively: 17%, odds ratio=1.340, 95% CI=1.031, 1.742; 19%, odds ratio=1.523, 95% CI=1.190, 1.949; and 20%, odds ratio=1.683, 95% CI=1.285, 2.206; difference in progesterone-to-estradiol ratios, respectively: -61, 95% CI=-105.492, -16.095; -78, 95% CI=-119.322, -37.039; and -71, 95% CI=-114.568, -27.534). In males, a higher progesterone-to-estradiol ratio was related to lower probabilities of binge drinking and of any alcohol use, with a 10-unit increase in the hormone ratio resulting in odds ratios of 0.918 (95% CI=0.843, 0.999) and 0.914 (95% CI=0.845, 0.988), respectively., Conclusions: These ecologically valid findings suggest that high progesterone-to-estradiol ratios can have a protective effect against problematic alcohol use in females and males with AUD, highlighting the progesterone-to-estradiol ratio as a promising treatment target. Moreover, the results indicate that females with AUD may benefit from menstrual cycle phase-tailored treatments.
- Published
- 2024
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29. Patterns of Alcohol Consumption Among Individuals With Alcohol Use Disorder During the COVID-19 Pandemic and Lockdowns in Germany.
- Author
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Deeken F, Reichert M, Zech H, Wenzel J, Wedemeyer F, Aguilera A, Aslan A, Bach P, Bahr NS, Ebrahimi C, Fischbach PC, Ganz M, Garbusow M, Großkopf CM, Heigert M, Hentschel A, Karl D, Pelz P, Pinger M, Riemerschmid C, Rosenthal A, Steffen J, Strehle J, Weiss F, Wieder G, Wieland A, Zaiser J, Zimmermann S, Walter H, Lenz B, Deserno L, Smolka MN, Liu S, Ebner-Priemer UW, Heinz A, and Rapp MA
- Subjects
- Adult, Alcohol Drinking epidemiology, Alcohol Drinking psychology, Cohort Studies, Communicable Disease Control, Female, Germany epidemiology, Humans, Longitudinal Studies, Male, Pandemics, Alcoholism epidemiology, COVID-19 epidemiology, Substance Withdrawal Syndrome
- Abstract
Importance: Alcohol consumption (AC) leads to death and disability worldwide. Ongoing discussions on potential negative effects of the COVID-19 pandemic on AC need to be informed by real-world evidence., Objective: To examine whether lockdown measures are associated with AC and consumption-related temporal and psychological within-person mechanisms., Design, Setting, and Participants: This quantitative, intensive, longitudinal cohort study recruited 1743 participants from 3 sites from February 20, 2020, to February 28, 2021. Data were provided before and within the second lockdown of the COVID-19 pandemic in Germany: before lockdown (October 2 to November 1, 2020); light lockdown (November 2 to December 15, 2020); and hard lockdown (December 16, 2020, to February 28, 2021)., Main Outcomes and Measures: Daily ratings of AC (main outcome) captured during 3 lockdown phases (main variable) and temporal (weekends and holidays) and psychological (social isolation and drinking intention) correlates., Results: Of the 1743 screened participants, 189 (119 [63.0%] male; median [IQR] age, 37 [27.5-52.0] years) with at least 2 alcohol use disorder (AUD) criteria according to the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) yet without the need for medically supervised alcohol withdrawal were included. These individuals provided 14 694 smartphone ratings from October 2020 through February 2021. Multilevel modeling revealed significantly higher AC (grams of alcohol per day) on weekend days vs weekdays (β = 11.39; 95% CI, 10.00-12.77; P < .001). Alcohol consumption was above the overall average on Christmas (β = 26.82; 95% CI, 21.87-31.77; P < .001) and New Year's Eve (β = 66.88; 95% CI, 59.22-74.54; P < .001). During the hard lockdown, perceived social isolation was significantly higher (β = 0.12; 95% CI, 0.06-0.15; P < .001), but AC was significantly lower (β = -5.45; 95% CI, -8.00 to -2.90; P = .001). Independent of lockdown, intention to drink less alcohol was associated with lower AC (β = -11.10; 95% CI, -13.63 to -8.58; P < .001). Notably, differences in AC between weekend and weekdays decreased both during the hard lockdown (β = -6.14; 95% CI, -9.96 to -2.31; P = .002) and in participants with severe AUD (β = -6.26; 95% CI, -10.18 to -2.34; P = .002)., Conclusions and Relevance: This 5-month cohort study found no immediate negative associations of lockdown measures with overall AC. Rather, weekend-weekday and holiday AC patterns exceeded lockdown effects. Differences in AC between weekend days and weekdays evinced that weekend drinking cycles decreased as a function of AUD severity and lockdown measures, indicating a potential mechanism of losing and regaining control. This finding suggests that temporal patterns and drinking intention constitute promising targets for prevention and intervention, even in high-risk individuals.
- Published
- 2022
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30. The IMAGEN study: a decade of imaging genetics in adolescents.
- Author
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Mascarell Maričić L, Walter H, Rosenthal A, Ripke S, Quinlan EB, Banaschewski T, Barker GJ, Bokde ALW, Bromberg U, Büchel C, Desrivières S, Flor H, Frouin V, Garavan H, Itterman B, Martinot JL, Martinot MP, Nees F, Orfanos DP, Paus T, Poustka L, Hohmann S, Smolka MN, Fröhner JH, Whelan R, Kaminski J, Schumann G, and Heinz A
- Subjects
- Adolescent, Cohort Studies, Humans, Reproducibility of Results, Reward, Time Factors, Adolescent Behavior, Genetics, Multicenter Studies as Topic, Neuroimaging
- Abstract
Imaging genetics offers the possibility of detecting associations between genotype and brain structure as well as function, with effect sizes potentially exceeding correlations between genotype and behavior. However, study results are often limited due to small sample sizes and methodological differences, thus reducing the reliability of findings. The IMAGEN cohort with 2000 young adolescents assessed from the age of 14 onwards tries to eliminate some of these limitations by offering a longitudinal approach and sufficient sample size for analyzing gene-environment interactions on brain structure and function. Here, we give a systematic review of IMAGEN publications since the start of the consortium. We then focus on the specific phenotype 'drug use' to illustrate the potential of the IMAGEN approach. We describe findings with respect to frontocortical, limbic and striatal brain volume, functional activation elicited by reward anticipation, behavioral inhibition, and affective faces, and their respective associations with drug intake. In addition to describing its strengths, we also discuss limitations of the IMAGEN study. Because of the longitudinal design and related attrition, analyses are underpowered for (epi-) genome-wide approaches due to the limited sample size. Estimating the generalizability of results requires replications in independent samples. However, such densely phenotyped longitudinal studies are still rare and alternative internal cross-validation methods (e.g., leave-one out, split-half) are also warranted. In conclusion, the IMAGEN cohort is a unique, very well characterized longitudinal sample, which helped to elucidate neurobiological mechanisms involved in complex behavior and offers the possibility to further disentangle genotype × phenotype interactions.
- Published
- 2020
- Full Text
- View/download PDF
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