829 results on '"Rosenstein, Barry"'
Search Results
2. Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score
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Huynh-Le, Minh-Phuong, Karunamuni, Roshan, Fan, Chun Chieh, Asona, Lui, Thompson, Wesley K, Martinez, Maria Elena, Eeles, Rosalind A, Kote-Jarai, Zsofia, Muir, Kenneth R, Lophatananon, Artitaya, Schleutker, Johanna, Pashayan, Nora, Batra, Jyotsna, Grönberg, Henrik, Neal, David E, Nordestgaard, Børge G, Tangen, Catherine M, MacInnis, Robert J, Wolk, Alicja, Albanes, Demetrius, Haiman, Christopher A, Travis, Ruth C, Blot, William J, Stanford, Janet L, Mucci, Lorelei A, West, Catharine ML, Nielsen, Sune F, Kibel, Adam S, Cussenot, Olivier, Berndt, Sonja I, Koutros, Stella, Sørensen, Karina Dalsgaard, Cybulski, Cezary, Grindedal, Eli Marie, Menegaux, Florence, Park, Jong Y, Ingles, Sue A, Maier, Christiane, Hamilton, Robert J, Rosenstein, Barry S, Lu, Yong-Jie, Watya, Stephen, Vega, Ana, Kogevinas, Manolis, Wiklund, Fredrik, Penney, Kathryn L, Huff, Chad D, Teixeira, Manuel R, Multigner, Luc, Leach, Robin J, Brenner, Hermann, John, Esther M, Kaneva, Radka, Logothetis, Christopher J, Neuhausen, Susan L, De Ruyck, Kim, Ost, Piet, Razack, Azad, Newcomb, Lisa F, Fowke, Jay H, Gamulin, Marija, Abraham, Aswin, Claessens, Frank, Castelao, Jose Esteban, Townsend, Paul A, Crawford, Dana C, Petrovics, Gyorgy, van Schaik, Ron HN, Parent, Marie-Élise, Hu, Jennifer J, Zheng, Wei, Mills, Ian G, Andreassen, Ole A, Dale, Anders M, and Seibert, Tyler M
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Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Prevention ,Cancer ,Health Disparities ,Prostate Cancer ,Aging ,Genetics ,Precision Medicine ,Urologic Diseases ,Minority Health ,Good Health and Well Being ,Male ,Humans ,Prostate-Specific Antigen ,Prostatic Neoplasms ,Early Detection of Cancer ,Polymorphism ,Single Nucleotide ,Risk Factors ,Risk Assessment ,Genetic Predisposition to Disease ,UKGPCS collaborators ,APCB ,NC-LA PCaP Investigators ,IMPACT Study Steering Committee and Collaborators ,Canary PASS Investigators ,Profile Study Steering Committee ,PRACTICAL Consortium ,Urology & Nephrology ,Clinical sciences ,Oncology and carcinogenesis - Abstract
BackgroundProstate cancer risk stratification using single-nucleotide polymorphisms (SNPs) demonstrates considerable promise in men of European, Asian, and African genetic ancestries, but there is still need for increased accuracy. We evaluated whether including additional SNPs in a prostate cancer polygenic hazard score (PHS) would improve associations with clinically significant prostate cancer in multi-ancestry datasets.MethodsIn total, 299 SNPs previously associated with prostate cancer were evaluated for inclusion in a new PHS, using a LASSO-regularized Cox proportional hazards model in a training dataset of 72,181 men from the PRACTICAL Consortium. The PHS model was evaluated in four testing datasets: African ancestry, Asian ancestry, and two of European Ancestry-the Cohort of Swedish Men (COSM) and the ProtecT study. Hazard ratios (HRs) were estimated to compare men with high versus low PHS for association with clinically significant, with any, and with fatal prostate cancer. The impact of genetic risk stratification on the positive predictive value (PPV) of PSA testing for clinically significant prostate cancer was also measured.ResultsThe final model (PHS290) had 290 SNPs with non-zero coefficients. Comparing, for example, the highest and lowest quintiles of PHS290, the hazard ratios (HRs) for clinically significant prostate cancer were 13.73 [95% CI: 12.43-15.16] in ProtecT, 7.07 [6.58-7.60] in African ancestry, 10.31 [9.58-11.11] in Asian ancestry, and 11.18 [10.34-12.09] in COSM. Similar results were seen for association with any and fatal prostate cancer. Without PHS stratification, the PPV of PSA testing for clinically significant prostate cancer in ProtecT was 0.12 (0.11-0.14). For the top 20% and top 5% of PHS290, the PPV of PSA testing was 0.19 (0.15-0.22) and 0.26 (0.19-0.33), respectively.ConclusionsWe demonstrate better genetic risk stratification for clinically significant prostate cancer than prior versions of PHS in multi-ancestry datasets. This is promising for implementing precision-medicine approaches to prostate cancer screening decisions in diverse populations.
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- 2022
3. Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
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Wang, Anqi, Shen, Jiayi, Rodriguez, Alex A., Saunders, Edward J., Chen, Fei, Janivara, Rohini, Darst, Burcu F., Sheng, Xin, Xu, Yili, Chou, Alisha J., Benlloch, Sara, Dadaev, Tokhir, Brook, Mark N., Plym, Anna, Sahimi, Ali, Hoffman, Thomas J., Takahashi, Atushi, Matsuda, Koichi, Momozawa, Yukihide, Fujita, Masashi, Laisk, Triin, Figuerêdo, Jéssica, Muir, Kenneth, Ito, Shuji, Liu, Xiaoxi, Uchio, Yuji, Kubo, Michiaki, Kamatani, Yoichiro, Lophatananon, Artitaya, Wan, Peggy, Andrews, Caroline, Lori, Adriana, Choudhury, Parichoy P., Schleutker, Johanna, Tammela, Teuvo L. J., Sipeky, Csilla, Auvinen, Anssi, Giles, Graham G., Southey, Melissa C., MacInnis, Robert J., Cybulski, Cezary, Wokolorczyk, Dominika, Lubinski, Jan, Rentsch, Christopher T., Cho, Kelly, Mcmahon, Benjamin H., Neal, David E., Donovan, Jenny L., Hamdy, Freddie C., Martin, Richard M., Nordestgaard, Borge G., Nielsen, Sune F., Weischer, Maren, Bojesen, Stig E., Røder, Andreas, Stroomberg, Hein V., Batra, Jyotsna, Chambers, Suzanne, Horvath, Lisa, Clements, Judith A., Tilly, Wayne, Risbridger, Gail P., Gronberg, Henrik, Aly, Markus, Szulkin, Robert, Eklund, Martin, Nordstrom, Tobias, Pashayan, Nora, Dunning, Alison M., Ghoussaini, Maya, Travis, Ruth C., Key, Tim J., Riboli, Elio, Park, Jong Y., Sellers, Thomas A., Lin, Hui-Yi, Albanes, Demetrius, Weinstein, Stephanie, Cook, Michael B., Mucci, Lorelei A., Giovannucci, Edward, Lindstrom, Sara, Kraft, Peter, Hunter, David J., Penney, Kathryn L., Turman, Constance, Tangen, Catherine M., Goodman, Phyllis J., Thompson, Jr., Ian M., Hamilton, Robert J., Fleshner, Neil E., Finelli, Antonio, Parent, Marie-Élise, Stanford, Janet L., Ostrander, Elaine A., Koutros, Stella, Beane Freeman, Laura E., Stampfer, Meir, Wolk, Alicja, Håkansson, Niclas, Andriole, Gerald L., Hoover, Robert N., Machiela, Mitchell J., Sørensen, Karina Dalsgaard, Borre, Michael, Blot, William J., Zheng, Wei, Yeboah, Edward D., Mensah, James E., Lu, Yong-Jie, Zhang, Hong-Wei, Feng, Ninghan, Mao, Xueying, Wu, Yudong, Zhao, Shan-Chao, Sun, Zan, Thibodeau, Stephen N., McDonnell, Shannon K., Schaid, Daniel J., West, Catharine M. L., Barnett, Gill, Maier, Christiane, Schnoeller, Thomas, Luedeke, Manuel, Kibel, Adam S., Drake, Bettina F., Cussenot, Olivier, Cancel-Tassin, Geraldine, Menegaux, Florence, Truong, Thérèse, Koudou, Yves Akoli, John, Esther M., Grindedal, Eli Marie, Maehle, Lovise, Khaw, Kay-Tee, Ingles, Sue A., Stern, Mariana C., Vega, Ana, Gómez-Caamaño, Antonio, Fachal, Laura, Rosenstein, Barry S., Kerns, Sarah L., Ostrer, Harry, Teixeira, Manuel R., Paulo, Paula, Brandão, Andreia, Watya, Stephen, Lubwama, Alexander, Bensen, Jeannette T., Butler, Ebonee N., Mohler, James L., Taylor, Jack A., Kogevinas, Manolis, Dierssen-Sotos, Trinidad, Castaño-Vinyals, Gemma, Cannon-Albright, Lisa, Teerlink, Craig C., Huff, Chad D., Pilie, Patrick, Yu, Yao, Bohlender, Ryan J., Gu, Jian, Strom, Sara S., Multigner, Luc, Blanchet, Pascal, Brureau, Laurent, Kaneva, Radka, Slavov, Chavdar, Mitev, Vanio, Leach, Robin J., Brenner, Hermann, Chen, Xuechen, Holleczek, Bernd, Schöttker, Ben, Klein, Eric A., Hsing, Ann W., Kittles, Rick A., Murphy, Adam B., Logothetis, Christopher J., Kim, Jeri, Neuhausen, Susan L., Steele, Linda, Ding, Yuan Chun, Isaacs, William B., Nemesure, Barbara, Hennis, Anselm J. M., Carpten, John, Pandha, Hardev, Michael, Agnieszka, De Ruyck, Kim, De Meerleer, Gert, Ost, Piet, Xu, Jianfeng, Razack, Azad, Lim, Jasmine, Teo, Soo-Hwang, Newcomb, Lisa F., Lin, Daniel W., Fowke, Jay H., Neslund-Dudas, Christine M., Rybicki, Benjamin A., Gamulin, Marija, Lessel, Davor, Kulis, Tomislav, Usmani, Nawaid, Abraham, Aswin, Singhal, Sandeep, Parliament, Matthew, Claessens, Frank, Joniau, Steven, Van den Broeck, Thomas, Gago-Dominguez, Manuela, Castelao, Jose Esteban, Martinez, Maria Elena, Larkin, Samantha, Townsend, Paul A., Aukim-Hastie, Claire, Bush, William S., Aldrich, Melinda C., Crawford, Dana C., Srivastava, Shiv, Cullen, Jennifer, Petrovics, Gyorgy, Casey, Graham, Wang, Ying, Tettey, Yao, Lachance, Joseph, Tang, Wei, Biritwum, Richard B., Adjei, Andrew A., Tay, Evelyn, Truelove, Ann, Niwa, Shelley, Yamoah, Kosj, Govindasami, Koveela, Chokkalingam, Anand P., Keaton, Jacob M., Hellwege, Jacklyn N., Clark, Peter E., Jalloh, Mohamed, Gueye, Serigne M., Niang, Lamine, Ogunbiyi, Olufemi, Shittu, Olayiwola, Amodu, Olukemi, Adebiyi, Akindele O., Aisuodionoe-Shadrach, Oseremen I., Ajibola, Hafees O., Jamda, Mustapha A., Oluwole, Olabode P., Nwegbu, Maxwell, Adusei, Ben, Mante, Sunny, Darkwa-Abrahams, Afua, Diop, Halimatou, Gundell, Susan M., Roobol, Monique J., Jenster, Guido, van Schaik, Ron H. N., Hu, Jennifer J., Sanderson, Maureen, Kachuri, Linda, Varma, Rohit, McKean-Cowdin, Roberta, Torres, Mina, Preuss, Michael H., Loos, Ruth J. F., Zawistowski, Matthew, Zöllner, Sebastian, Lu, Zeyun, Van Den Eeden, Stephen K., Easton, Douglas F., Ambs, Stefan, Edwards, Todd L., Mägi, Reedik, Rebbeck, Timothy R., Fritsche, Lars, Chanock, Stephen J., Berndt, Sonja I., Wiklund, Fredrik, Nakagawa, Hidewaki, Witte, John S., Gaziano, J. Michael, Justice, Amy C., Mancuso, Nick, Terao, Chikashi, Eeles, Rosalind A., Kote-Jarai, Zsofia, Madduri, Ravi K., Conti, David V., and Haiman, Christopher A.
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- 2023
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4. Optimising inter-patient image registration for image-based data mining in breast radiotherapy
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Jaikuna, Tanwiwat, Wilson, Fiona, Azria, David, Chang-Claude, Jenny, De Santis, Maria Carmen, Gutiérrez-Enríquez, Sara, van Herk, Marcel, Hoskin, Peter, Kotzki, Lea, Lambrecht, Maarten, Lingard, Zoe, Seibold, Petra, Seoane, Alejandro, Sperk, Elena, Paul Symonds, R, Talbot, Christopher J., Rancati, Tiziana, Rattay, Tim, Reyes, Victoria, Rosenstein, Barry S., de Ruysscher, Dirk, Vega, Ana, Veldeman, Liv, Webb, Adam, West, Catharine ML, Aznar, Marianne C, and Vasquez Osorio, Eliana
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- 2024
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5. Germline genomics in radiotherapy
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Rosenstein, Barry S., primary, West, Catharine, additional, Kerns, Sarah, additional, Barnett, Gill, additional, and Zuhour, Raed, additional
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- 2024
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6. Contributors
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Ahmed, Sara, primary, Au Yong, Tracy P.T., additional, Bakst, Richard, additional, Barnett, Gill, additional, Bond, Sarah, additional, Boon, Ian S., additional, Boon, Cheng S., additional, Buckstein, Michael, additional, Chen, Liyuan, additional, Chowdhry, Amit Kumar, additional, Cui, Sunan, additional, Dekker, Andre, additional, Dohopolski, Michael, additional, El-Charif, Omar, additional, El Naqa, Issam, additional, Fijten, Rianne, additional, Fuller, Clifton D., additional, Green, Andrew, additional, Jain, Anshu, additional, Kalendralis, Petros, additional, Kalet, Alan M., additional, Kang, John, additional, Kann, Benjamin H., additional, Kerns, Sarah, additional, Kim, Ellen, additional, Kiser, Kendall J., additional, Levitin, Ronald, additional, Liu, Jinyuan, additional, Lyon, Robert J., additional, McCoy, Lance A., additional, McDonald, Brigid A., additional, McWilliam, Alan, additional, Milano, Michael, additional, Mulder, Samuel, additional, Nayak, Stuti, additional, Nobel, Martijn, additional, Placide, John, additional, Porter, Evan, additional, Preston, Kathryn, additional, Puts, Sander, additional, Pybus, Matt, additional, Rashid, Arif S., additional, Rattay, Tim, additional, Rosenstein, Barry S., additional, Sanders, Keith L., additional, Sanjay, Aneja, additional, Schwartz, Russell, additional, Sharafi, Christina Setareh, additional, Sher, David, additional, Shumway, John, additional, Siddiqui, Zaid, additional, Speers, Corey, additional, Strawderman, Robert, additional, Tao, Yifeng, additional, Thomas, Charles R., additional, Thompson, Reid F., additional, Tu, Xin Ming, additional, Tu, Justin Xiang-Yuan, additional, Vallières, Martin, additional, van Dijk, Lisanne V., additional, Ventura, Juan, additional, Wahid, Kareem A., additional, Wald, Hedy S., additional, Wang, Jing, additional, Wasserman, Jason Adam, additional, West, Catharine, additional, Yang, Kun, additional, Yap, Moi Hoon, additional, Yuan, Yading, additional, Yuan, Ye, additional, Zegers, Catharina, additional, Zhu, Lin L., additional, and Zuhour, Raed, additional
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- 2024
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7. Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis
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Landi, Maria Teresa, Stevens, Victoria, Wang, Ying, Albanes, Demetrios, Caporaso, Neil, Brennan, Paul, Amos, Christopher I., Shete, Sanjay, Hung, Rayjean J., Bickeböller, Heike, Risch, Angela, Houlston, Richard, Lam, Stephen, Tardon, Adonina, Chen, Chu, Bojesen, Stig E., Johansson, Mattias, Wichmann, H-Erich, Christiani, David, Rennert, Gadi, Arnold, Susanne, Field, John K., Le Marchand, Loic, Melander, Olle, Brunnström, Hans, Liu, Geoffrey, Andrew, Angeline, Kiemeney, Lambertus A., Shen, Hongbing, Zienolddiny, Shan, Grankvist, Kjell, Johansson, Mikael, Teare, M. Dawn, Hong, Yun-Chul, Yuan, Jian-Min, Lazarus, Philip, Schabath, Matthew B., Aldrich, Melinda C., Eeles, Rosalind A., Haiman, Christopher A., Kote-Jarai, Zsofia, Schumacher, Fredrick R., Benlloch, Sara, Al Olama, Ali Amin, Muir, Kenneth R., Berndt, Sonja I., Conti, David V., Wiklund, Fredrik, Chanock, Stephen, Tangen, Catherine M., Batra, Jyotsna, Clements, Judith A., Grönberg, Henrik, Pashayan, Nora, Schleutker, Johanna, Albanes, Demetrius, Weinstein, Stephanie J., Wolk, Alicja, West, Catharine M.L., Mucci, Lorelei A., Cancel-Tassin, Géraldine, Koutros, Stella, Sørensen, Karina Dalsgaard, Grindedal, Eli Marie, Neal, David E., Hamdy, Freddie C., Donovan, Jenny L., Travis, Ruth C., Hamilton, Robert J., Ingles, Sue Ann, Rosenstein, Barry S., Lu, Yong-Jie, Giles, Graham G., MacInnis, Robert J., Kibel, Adam S., Vega, Ana, Kogevinas, Manolis, Penney, Kathryn L., Park, Jong Y., Stanfrod, Janet L., Cybulski, Cezary, Nordestgaard, Børge G., Nielsen, Sune F., Brenner, Hermann, Maier, Christiane, Logothetis, Christopher J., John, Esther M., Teixeira, Manuel R., Neuhausen, Susan L., De Ruyck, Kim, Razack, Azad, Newcomb, Lisa F., Lessel, Davor, Kaneva, Radka, Usmani, Nawaid, Claessens, Frank, Townsend, Paul A., Castelao, Jose Esteban, Roobol, Monique J., Menegaux, Florence, Khaw, Kay-Tee, Cannon-Albright, Lisa, Pandha, Hardev, Thibodeau, Stephen N., Hunter, David J., Kraft, Peter, Blot, William J., Riboli, Elio, Yarmolinsky, James, Robinson, Jamie W., Mariosa, Daniela, Karhunen, Ville, Huang, Jian, Dimou, Niki, Murphy, Neil, Burrows, Kimberley, Bouras, Emmanouil, Smith-Byrne, Karl, Lewis, Sarah J., Galesloot, Tessel E., Vermeulen, Sita, Martin, Paul, Hou, Lifang, Newcomb, Polly A., White, Emily, Wu, Anna H., Le Marchand, Loïc, Phipps, Amanda I., Buchanan, Daniel D., Zhao, Sizheng Steven, Gill, Dipender, Chanock, Stephen J., Purdue, Mark P., Davey Smith, George, Herzig, Karl-Heinz, Järvelin, Marjo-Riitta, Amos, Chris I., Dehghan, Abbas, Gunter, Marc J., Tsilidis, Kostas K., and Martin, Richard M.
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- 2024
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8. Additional SNPs improve risk stratification of a polygenic hazard score for prostate cancer.
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Karunamuni, Roshan A, Huynh-Le, Minh-Phuong, Fan, Chun C, Thompson, Wesley, Eeles, Rosalind A, Kote-Jarai, Zsofia, Muir, Kenneth, Lophatananon, Artitaya, UKGPCS collaborators, Schleutker, Johanna, Pashayan, Nora, Batra, Jyotsna, APCB BioResource (Australian Prostate Cancer BioResource), Grönberg, Henrik, Walsh, Eleanor I, Turner, Emma L, Lane, Athene, Martin, Richard M, Neal, David E, Donovan, Jenny L, Hamdy, Freddie C, Nordestgaard, Børge G, Tangen, Catherine M, MacInnis, Robert J, Wolk, Alicja, Albanes, Demetrius, Haiman, Christopher A, Travis, Ruth C, Stanford, Janet L, Mucci, Lorelei A, West, Catharine ML, Nielsen, Sune F, Kibel, Adam S, Wiklund, Fredrik, Cussenot, Olivier, Berndt, Sonja I, Koutros, Stella, Sørensen, Karina Dalsgaard, Cybulski, Cezary, Grindedal, Eli Marie, Park, Jong Y, Ingles, Sue A, Maier, Christiane, Hamilton, Robert J, Rosenstein, Barry S, Vega, Ana, IMPACT Study Steering Committee and Collaborators, Kogevinas, Manolis, Penney, Kathryn L, Teixeira, Manuel R, Brenner, Hermann, John, Esther M, Kaneva, Radka, Logothetis, Christopher J, Neuhausen, Susan L, Razack, Azad, Newcomb, Lisa F, Canary PASS Investigators, Gamulin, Marija, Usmani, Nawaid, Claessens, Frank, Gago-Dominguez, Manuela, Townsend, Paul A, Roobol, Monique J, Zheng, Wei, Profile Study Steering Committee, Mills, Ian G, Andreassen, Ole A, Dale, Anders M, Seibert, Tyler M, and PRACTICAL Consortium
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UKGPCS collaborators ,APCB BioResource ,IMPACT Study Steering Committee and Collaborators ,Canary PASS Investigators ,Profile Study Steering Committee ,PRACTICAL Consortium ,Prevention ,Urologic Diseases ,Cancer ,Prostate Cancer ,Aging ,Urology & Nephrology ,Oncology and Carcinogenesis - Abstract
BackgroundPolygenic hazard scores (PHS) can identify individuals with increased risk of prostate cancer. We estimated the benefit of additional SNPs on performance of a previously validated PHS (PHS46).Materials and method180 SNPs, shown to be previously associated with prostate cancer, were used to develop a PHS model in men with European ancestry. A machine-learning approach, LASSO-regularized Cox regression, was used to select SNPs and to estimate their coefficients in the training set (75,596 men). Performance of the resulting model was evaluated in the testing/validation set (6,411 men) with two metrics: (1) hazard ratios (HRs) and (2) positive predictive value (PPV) of prostate-specific antigen (PSA) testing. HRs were estimated between individuals with PHS in the top 5% to those in the middle 40% (HR95/50), top 20% to bottom 20% (HR80/20), and bottom 20% to middle 40% (HR20/50). PPV was calculated for the top 20% (PPV80) and top 5% (PPV95) of PHS as the fraction of individuals with elevated PSA that were diagnosed with clinically significant prostate cancer on biopsy.Results166 SNPs had non-zero coefficients in the Cox model (PHS166). All HR metrics showed significant improvements for PHS166 compared to PHS46: HR95/50 increased from 3.72 to 5.09, HR80/20 increased from 6.12 to 9.45, and HR20/50 decreased from 0.41 to 0.34. By contrast, no significant differences were observed in PPV of PSA testing for clinically significant prostate cancer.ConclusionsIncorporating 120 additional SNPs (PHS166 vs PHS46) significantly improved HRs for prostate cancer, while PPV of PSA testing remained the same.
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- 2021
9. Contouring variation affects estimates of normal tissue complication probability for breast fibrosis after radiotherapy
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Jaikuna, Tanwiwat, Osorio, Eliana Vasquez, Azria, David, Chang-Claude, Jenny, De Santis, Maria Carmen, Gutiérrez-Enríquez, Sara, van Herk, Marcel, Hoskin, Peter, Lambrecht, Maarten, Lingard, Zoe, Seibold, Petra, Seoane, Alejandro, Sperk, Elena, Symonds, R Paul, Talbot, Christopher J., Rancati, Tiziana, Rattay, Tim, Reyes, Victoria, Rosenstein, Barry S., de Ruysscher, Dirk, Vega, Ana, Veldeman, Liv, Webb, Adam, West, Catharine M.L., and Aznar, Marianne C.
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- 2023
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10. Polygenic hazard score is associated with prostate cancer in multi-ethnic populations.
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Huynh-Le, Minh-Phuong, Fan, Chun Chieh, Karunamuni, Roshan, Thompson, Wesley K, Martinez, Maria Elena, Eeles, Rosalind A, Kote-Jarai, Zsofia, Muir, Kenneth, Schleutker, Johanna, Pashayan, Nora, Batra, Jyotsna, Grönberg, Henrik, Neal, David E, Donovan, Jenny L, Hamdy, Freddie C, Martin, Richard M, Nielsen, Sune F, Nordestgaard, Børge G, Wiklund, Fredrik, Tangen, Catherine M, Giles, Graham G, Wolk, Alicja, Albanes, Demetrius, Travis, Ruth C, Blot, William J, Zheng, Wei, Sanderson, Maureen, Stanford, Janet L, Mucci, Lorelei A, West, Catharine ML, Kibel, Adam S, Cussenot, Olivier, Berndt, Sonja I, Koutros, Stella, Sørensen, Karina Dalsgaard, Cybulski, Cezary, Grindedal, Eli Marie, Menegaux, Florence, Khaw, Kay-Tee, Park, Jong Y, Ingles, Sue A, Maier, Christiane, Hamilton, Robert J, Thibodeau, Stephen N, Rosenstein, Barry S, Lu, Yong-Jie, Watya, Stephen, Vega, Ana, Kogevinas, Manolis, Penney, Kathryn L, Huff, Chad, Teixeira, Manuel R, Multigner, Luc, Leach, Robin J, Cannon-Albright, Lisa, Brenner, Hermann, John, Esther M, Kaneva, Radka, Logothetis, Christopher J, Neuhausen, Susan L, De Ruyck, Kim, Pandha, Hardev, Razack, Azad, Newcomb, Lisa F, Fowke, Jay H, Gamulin, Marija, Usmani, Nawaid, Claessens, Frank, Gago-Dominguez, Manuela, Townsend, Paul A, Bush, William S, Roobol, Monique J, Parent, Marie-Élise, Hu, Jennifer J, Mills, Ian G, Andreassen, Ole A, Dale, Anders M, Seibert, Tyler M, UKGPCS collaborators, APCB (Australian Prostate Cancer BioResource), NC-LA PCaP Investigators, IMPACT Study Steering Committee and Collaborators, Canary PASS Investigators, Profile Study Steering Committee, and PRACTICAL Consortium
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UKGPCS collaborators ,APCB ,NC-LA PCaP Investigators ,IMPACT Study Steering Committee and Collaborators ,Canary PASS Investigators ,Profile Study Steering Committee ,PRACTICAL Consortium ,Humans ,Prostatic Neoplasms ,Neoplasm Invasiveness ,Multivariate Analysis ,Multifactorial Inheritance ,Aged ,Middle Aged ,Ethnic Groups ,Male ,Self Report ,Aging ,Urologic Diseases ,Cancer ,Prostate Cancer - Abstract
Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance of PHS2 (PHS1, adapted for OncoArray) in a multi-ethnic dataset of 80,491 men (49,916 cases, 30,575 controls). PHS2 is associated with age at diagnosis of any and aggressive (Gleason score ≥ 7, stage T3-T4, PSA ≥ 10 ng/mL, or nodal/distant metastasis) cancer and prostate-cancer-specific death. Associations with cancer are significant within European (n = 71,856), Asian (n = 2,382), and African (n = 6,253) genetic ancestries (p
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- 2021
11. Genome-wide association study of treatment-related toxicity two years following radiotherapy for breast cancer
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Jandu, Harkeran K., Veal, Colin D., Fachal, Laura, Luccarini, Craig, Aguado-Barrera, Miguel E., Altabas, Manuel, Azria, David, Baten, Adinda, Bourgier, Celine, Bultijnck, Renée, Colciago, Riccardo R., Farcy-Jacquet, Marie-Pierre, Chang-Claude, Jenny, Choudhury, Ananya, Dunning, Alison, Elliott, Rebecca M., Green, Sheryl, Gutiérrez-Enríquez, Sara, Herskind, Carsten, Lambrecht, Maarten, Monten, Christel, Rancati, Tiziana, Reyes, Victoria, Rosenstein, Barry S., De Ruysscher, Dirk, Carmen De Santis, Maria, Seibold, Petra, Sperk, Elena, Veldwijk, Marlon, Paul Symonds, R., Stobart, Hilary, Taboada-Valladares, Begoña, Vega, Ana, Veldeman, Liv, Webb, Adam J., Weltens, Caroline, West, Catharine M., Rattay, Tim, and Talbot, Christopher J.
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- 2023
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12. Predicting the germline dependence of hematuria risk in prostate cancer radiotherapy patients
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Oh, Jung Hun, Lee, Sangkyu, Thor, Maria, Rosenstein, Barry S., Tannenbaum, Allen, Kerns, Sarah, and Deasy, Joseph O.
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- 2023
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13. Genomics models in radiotherapy: from mechanistic to machine learning
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Kang, John, Coates, James T., Strawderman, Robert L., Rosenstein, Barry S., and Kerns, Sarah L.
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Statistics - Applications ,Quantitative Biology - Genomics ,Quantitative Biology - Quantitative Methods - Abstract
Machine learning provides a broad framework for addressing high-dimensional prediction problems in classification and regression. While machine learning is often applied for imaging problems in medical physics, there are many efforts to apply these principles to biological data towards questions of radiation biology. Here, we provide a review of radiogenomics modeling frameworks and efforts towards genomically-guided radiotherapy. We first discuss medical oncology efforts to develop precision biomarkers. We next discuss similar efforts to create clinical assays for normal tissue or tumor radiosensitivity. We then discuss modeling frameworks for radiosensitivity and the evolution of machine learning to create predictive models for radiogenomics., Comment: 32 pages, 3 figures, 3 tables
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- 2019
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14. Comparing symptom reporting by prostate cancer patients and healthcare professionals in the international multicentre REQUITE study
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Heumann, Philipp, Aguado-Barrera, Miguel E., Avuzzi, Barbara, Azria, David, Briers, Erik, Bultijnck, Renée, Choudhury, Ananya, De Ruysscher, Dirk, Farcy-Jacquet, Marie-Pierre, Fonteyne, Valérie, Gómez Caamaño, Antonio, Helmbold, Irmgard, Johnson, Kerstie, Kerns, Sarah L., Lambrecht, Maarten, Lingard, Zoe, Rancati, Tiziana, Rosenstein, Barry S., Sperk, Elena, Paul Symonds, R., Talbot, Christopher, Valdagni, Riccardo, Vega, Ana, Veldeman, Liv, Ward, Tim, Webb, Adam, West, Catharine M., Chang-Claude, Jenny, and Seibold, Petra
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- 2023
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15. The correlation between pre-treatment symptoms, acute and late toxicity and patient-reported health-related quality of life in non-small cell lung cancer patients: Results of the REQUITE study
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van der Weijst, Lotte, Azria, David, Berkovic, Patrick, Boisselier, Pierre, Briers, Erik, Bultijnck, Renée, Chang-Claude, Jenny, Choudhury, Ananya, Defraene, Gilles, Demontois, Sylvian, Elliott, Rebecca M., Ennis, Dawn, Faivre-Finn, Corinne, Franceschini, Marzia, Giandini, Tommaso, Giraldo, Alexandra, Gutiérrez-Enríquez, Sara, Herskind, Carsten, Higginson, Daniel S., Kerns, Sarah L., Johnson, Kerstie, Lambrecht, Maarten, Lang, Philippe, Ramos, Mónica, Rancati, Tiziana, Rimner, Andreas, Rosenstein, Barry S., De Ruysscher, Dirk, Salem, Ahmed, Sangalli, Claudia, Seibold, Petra, Sosa Fajardo, Paloma, Sperk, Elena, Stobart, Hilary, Summersgill, Holly, Surmont, Veerle, Symonds, Paul, Taboada-Valladares, Begoña, Talbot, Christopher J., Vega, Ana, Veldeman, Liv, Veldwijk, Marlon R., Ward, Tim, Webb, Adam, West, Catharine M.L., and Lievens, Yolande
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- 2022
- Full Text
- View/download PDF
16. Treatment time and circadian genotype interact to influence radiotherapy side-effects. A prospective European validation study using the REQUITE cohort
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Webb, Adam J., Harper, Emily, Rattay, Tim, Aguado-Barrera, Miguel E., Azria, David, Bourgier, Celine, Brengues, Muriel, Briers, Erik, Bultijnck, Renée, Chang-Claude, Jenny, Choudhury, Ananya, Cicchetti, Alessandro, De Ruysscher, Dirk, De Santis, Maria Carmen, Dunning, Alison M., Elliott, Rebecca M., Fachal, Laura, Gómez-Caamaño, Antonio, Gutiérrez-Enríquez, Sara, Johnson, Kerstie, Lobato-Busto, Ramón, Kerns, Sarah L., Post, Giselle, Rancati, Tiziana, Reyes, Victoria, Rosenstein, Barry S., Seibold, Petra, Seoane, Alejandro, Sosa-Fajardo, Paloma, Sperk, Elena, Taboada-Valladares, Begoña, Valdagni, Riccardo, Vega, Ana, Veldeman, Liv, Ward, Tim, West, Catharine M., Symonds, R. Paul, and Talbot, Christopher J.
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- 2022
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17. Factors associated with late local failure and its influence on survival in men undergoing prostate brachytherapy
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Stone, Nelson N., Unger, Pamela D., Sheu, Rendi, Rosenstein, Barry S., and Stock, Richard G.
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- 2022
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18. Development and Optimization of a Machine-Learning Prediction Model for Acute Desquamation After Breast Radiation Therapy in the Multicenter REQUITE Cohort
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Aldraimli, Mahmoud, Osman, Sarah, Grishchuck, Diana, Ingram, Samuel, Lyon, Robert, Mistry, Anil, Oliveira, Jorge, Samuel, Robert, Shelley, Leila E.A., Soria, Daniele, Dwek, Miriam V., Aguado-Barrera, Miguel E., Azria, David, Chang-Claude, Jenny, Dunning, Alison, Giraldo, Alexandra, Green, Sheryl, Gutiérrez-Enríquez, Sara, Herskind, Carsten, van Hulle, Hans, Lambrecht, Maarten, Lozza, Laura, Rancati, Tiziana, Reyes, Victoria, Rosenstein, Barry S., de Ruysscher, Dirk, de Santis, Maria C., Seibold, Petra, Sperk, Elena, Symonds, R. Paul, Stobart, Hilary, Taboada-Valadares, Begoña, Talbot, Christopher J., Vakaet, Vincent J.L., Vega, Ana, Veldeman, Liv, Veldwijk, Marlon R., Webb, Adam, Weltens, Caroline, West, Catharine M., Chaussalet, Thierry J., and Rattay, Tim
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- 2022
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19. The Need to Enrich Population Diversity in Radiogenomic Research.
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Rosenstein, Barry S., Yamoah, Kosj, Bentzen, Søren M., Kerns, Sarah L., McDonald, J. Tyson, West, Catharine M.L., Vega, Ana, Rattay, Tim, and Ricks-Santi, Luisel J.
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- 2024
- Full Text
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20. Overview of health-related quality of life and toxicity of non-small cell lung cancer patients receiving curative-intent radiotherapy in a real-life setting (the REQUITE study)
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Van der Weijst, Lotte, Aguado-Barrera, Miguel E., Azria, David, Berkovic, Patrick, Boisselier, Pierre, Briers, Erik, Bultijnck, Renée, Calvo-Crespo, Patricia, Chang-Claude, Jenny, Choudhury, Ananya, Defraene, Gilles, Demontois, Sylvian, Dunning, Alison M., Elliott, Rebecca M., Ennis, Dawn, Faivre-Finn, Corinne, Franceschini, Marzia, Gutiérrez-Enríquez, Sara, Herskind, Carsten, Higginson, Daniel S., Kerns, Sarah L., Johnson, Kerstie, Mollà, Meritxell, Lambrecht, Maarten, Ramos, Mónica, Rancati, Tiziana, Rimner, Andreas, Rosenstein, Barry S., De Ruysscher, Dirk, Salem, Ahmed, Sangalli, Claudia, Seibold, Petra, Sosa-Fajardo, Paloma, Sperk, Elena, Stobart, Hilary, Summersgill, Holly, Surmont, Veerle, Symonds, Paul, Taboada-Lorenzo, Begoña, Talbot, Christopher J., Valdagni, Riccardo, Vega, Ana, Veldeman, Liv, Veldwijk, Marlon R., Ward, Tim, Webb, Adam, West, Catharine M.L., and Lievens, Yolande
- Published
- 2022
- Full Text
- View/download PDF
21. Use of angiotensin converting enzyme inhibitors is associated with reduced risk of late bladder toxicity following radiotherapy for prostate cancer
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Azria, David, Briers, Erik, Chang-Claude, Jenny, Choudhury, Ananya, Dunning, Alison, Elliott, Rebecca M, Gutiérrez-Enríquez, Sara, Rancati, Tiziana, Rattay, Tim, Rosenstein, Barry S., De Ruysscher, Dirk, Seibold, Petra, Sperk, Elena, Paul Symonds, R, Stobart, Hilary, Talbot, Christopher J., Vega, Ana, Veldeman, Liv, Ward, Tim, Webb, Adam, West, Catharine M., Kerns, Sarah L., Amidon Morlang, Ashley, Lee, Sharon M., Peterson, Derick R., Marples, Brian, Zhang, Hong, Bylund, Kevin, Rosenzweig, Doug, Hall, William, De Ruyck, Kim, Stock, Richard G., Gómez-Caamaño, Antonio, Sosa-Fajardo, Paloma, Taboada-Valladares, Begoña, Aguado-Barrera, Miguel E., Parker, Chris, Fonteyne, Valérie, Bultijnck, Renée, Symonds, R. Paul, Johnson, Kerstie, Lambrecht, Maarten, de Ruysscher, Dirk, Vanneste, Ben, Elliott, Rebecca M., Herskind, Carsten, Veldwijk, Marlon R., Avuzzi, Barbara, Valdagni, Riccardo, Farcy Jacquet, Marie-Pierre, West, Catharine, Janelsins, Michelle, Chen, Yuhchyau, Messing, Edward, and Morrow, Gary
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- 2022
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- View/download PDF
22. Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry.
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Matejcic, Marco, Saunders, Edward J, Dadaev, Tokhir, Brook, Mark N, Wang, Kan, Sheng, Xin, Olama, Ali Amin Al, Schumacher, Fredrick R, Ingles, Sue A, Govindasami, Koveela, Benlloch, Sara, Berndt, Sonja I, Albanes, Demetrius, Koutros, Stella, Muir, Kenneth, Stevens, Victoria L, Gapstur, Susan M, Tangen, Catherine M, Batra, Jyotsna, Clements, Judith, Gronberg, Henrik, Pashayan, Nora, Schleutker, Johanna, Wolk, Alicja, West, Catharine, Mucci, Lorelei, Kraft, Peter, Cancel-Tassin, Géraldine, Sorensen, Karina D, Maehle, Lovise, Grindedal, Eli M, Strom, Sara S, Neal, David E, Hamdy, Freddie C, Donovan, Jenny L, Travis, Ruth C, Hamilton, Robert J, Rosenstein, Barry, Lu, Yong-Jie, Giles, Graham G, Kibel, Adam S, Vega, Ana, Bensen, Jeanette T, Kogevinas, Manolis, Penney, Kathryn L, Park, Jong Y, Stanford, Janet L, Cybulski, Cezary, Nordestgaard, Børge G, Brenner, Hermann, Maier, Christiane, Kim, Jeri, Teixeira, Manuel R, Neuhausen, Susan L, De Ruyck, Kim, Razack, Azad, Newcomb, Lisa F, Lessel, Davor, Kaneva, Radka, Usmani, Nawaid, Claessens, Frank, Townsend, Paul A, Gago-Dominguez, Manuela, Roobol, Monique J, Menegaux, Florence, Khaw, Kay-Tee, Cannon-Albright, Lisa A, Pandha, Hardev, Thibodeau, Stephen N, Schaid, Daniel J, PRACTICAL Consortium, Wiklund, Fredrik, Chanock, Stephen J, Easton, Douglas F, Eeles, Rosalind A, Kote-Jarai, Zsofia, Conti, David V, and Haiman, Christopher A
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PRACTICAL Consortium - Abstract
The original version of this Article contained an error in the spelling of the author Manuela Gago-Dominguez, which was incorrectly given as Manuela G. Dominguez. This has now been corrected in both the PDF and HTML versions of the Article.
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- 2019
23. Performance/outcomes data and physician process challenges for practical big data efforts in radiation oncology
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Matuszak, Martha M, Fuller, Clifton D, Yock, Torunn I, Hess, Clayton B, McNutt, Todd, Jolly, Shruti, Gabriel, Peter, Mayo, Charles S, Thor, Maria, Caissie, Amanda, Rao, Arvind, Owen, Dawn, Smith, Wade, Palta, Jatinder, Kapoor, Rishabh, Hayman, James, Waddle, Mark, Rosenstein, Barry, Miller, Robert, Choi, Seungtaek, Moreno, Amy, Herman, Joseph, and Feng, Mary
- Subjects
Medical and Biological Physics ,Physical Sciences ,Cancer ,Networking and Information Technology R&D (NITRD) ,Databases ,Factual ,Humans ,Medical Informatics ,Outcome Assessment ,Health Care ,Physicians ,Radiation Oncology ,Registries ,Universities ,big data ,challenges ,outcomes ,performance ,physician ,radiation oncology ,Other Physical Sciences ,Biomedical Engineering ,Oncology and Carcinogenesis ,Nuclear Medicine & Medical Imaging ,Biomedical engineering ,Medical and biological physics - Abstract
It is an exciting time for big data efforts in radiation oncology. The use of big data to help aid both outcomes and decision-making research is becoming a reality. However, there are true challenges that exist in the space of gathering and utilizing performance and outcomes data. Here, we summarize the current state of big data in radiation oncology with respect to outcomes and discuss some of the efforts and challenges in radiation oncology big data.
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- 2018
24. Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci
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Schumacher, Fredrick R, Al Olama, Ali Amin, Berndt, Sonja I, Benlloch, Sara, Ahmed, Mahbubl, Saunders, Edward J, Dadaev, Tokhir, Leongamornlert, Daniel, Anokian, Ezequiel, Cieza-Borrella, Clara, Goh, Chee, Brook, Mark N, Sheng, Xin, Fachal, Laura, Dennis, Joe, Tyrer, Jonathan, Muir, Kenneth, Lophatananon, Artitaya, Stevens, Victoria L, Gapstur, Susan M, Carter, Brian D, Tangen, Catherine M, Goodman, Phyllis J, Thompson, Ian M, Batra, Jyotsna, Chambers, Suzanne, Moya, Leire, Clements, Judith, Horvath, Lisa, Tilley, Wayne, Risbridger, Gail P, Gronberg, Henrik, Aly, Markus, Nordström, Tobias, Pharoah, Paul, Pashayan, Nora, Schleutker, Johanna, Tammela, Teuvo LJ, Sipeky, Csilla, Auvinen, Anssi, Albanes, Demetrius, Weinstein, Stephanie, Wolk, Alicja, Håkansson, Niclas, West, Catharine ML, Dunning, Alison M, Burnet, Neil, Mucci, Lorelei A, Giovannucci, Edward, Andriole, Gerald L, Cussenot, Olivier, Cancel-Tassin, Géraldine, Koutros, Stella, Beane Freeman, Laura E, Sorensen, Karina Dalsgaard, Orntoft, Torben Falck, Borre, Michael, Maehle, Lovise, Grindedal, Eli Marie, Neal, David E, Donovan, Jenny L, Hamdy, Freddie C, Martin, Richard M, Travis, Ruth C, Key, Tim J, Hamilton, Robert J, Fleshner, Neil E, Finelli, Antonio, Ingles, Sue Ann, Stern, Mariana C, Rosenstein, Barry S, Kerns, Sarah L, Ostrer, Harry, Lu, Yong-Jie, Zhang, Hong-Wei, Feng, Ninghan, Mao, Xueying, Guo, Xin, Wang, Guomin, Sun, Zan, Giles, Graham G, Southey, Melissa C, MacInnis, Robert J, FitzGerald, Liesel M, Kibel, Adam S, Drake, Bettina F, Vega, Ana, Gómez-Caamaño, Antonio, Szulkin, Robert, Eklund, Martin, Kogevinas, Manolis, Llorca, Javier, Castaño-Vinyals, Gemma, Penney, Kathryn L, Stampfer, Meir, Park, Jong Y, Sellers, Thomas A, Lin, Hui-Yi, Stanford, Janet L, and Cybulski, Cezary
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Cancer ,Aging ,Prostate Cancer ,Genetics ,Urologic Diseases ,Human Genome ,2.1 Biological and endogenous factors ,Aetiology ,Case-Control Studies ,Genetic Loci ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Genotype ,Humans ,Male ,Polymorphism ,Single Nucleotide ,Prostatic Neoplasms ,Risk ,Profile Study ,Australian Prostate Cancer BioResource ,IMPACT Study ,Canary PASS Investigators ,Breast and Prostate Cancer Cohort Consortium ,PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium ,Cancer of the Prostate in Sweden ,Prostate Cancer Genome-wide Association Study of Uncommon Susceptibility Loci ,Genetic Associations and Mechanisms in Oncology (GAME-ON)/Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE) Consortium ,Biological Sciences ,Medical and Health Sciences ,Developmental Biology - Abstract
Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array of 46,939 PrCa cases and 27,910 controls of European ancestry with previously genotyped data of 32,255 PrCa cases and 33,202 controls of European ancestry. Our analysis identified 62 novel loci associated (P C, p.Pro1054Arg) in ATM and rs2066827 (OR = 1.06; P = 2.3 × 10-9; T>G, p.Val109Gly) in CDKN1B. The combination of all loci captured 28.4% of the PrCa familial relative risk, and a polygenic risk score conferred an elevated PrCa risk for men in the ninetieth to ninety-ninth percentiles (relative risk = 2.69; 95% confidence interval (CI): 2.55-2.82) and first percentile (relative risk = 5.71; 95% CI: 5.04-6.48) risk stratum compared with the population average. These findings improve risk prediction, enhance fine-mapping, and provide insight into the underlying biology of PrCa1.
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- 2018
25. Ocular complications with the use of radium-223: a case series
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Bloom, Julie R., Castillejos, Alexandra G., Jones, Brianna, Patel, Nimesh, Rosenstein, Barry S., and Stock, Richard G.
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- 2022
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- View/download PDF
26. Sexual health outcomes in sexual minority vs. heterosexual men after prostate radiotherapy.
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Dickstein, Daniel Robert, primary, Kapouranis, Thodoris, additional, Flynn, Kathryn E., additional, Sigel, Keith Magnus, additional, Nvepu, Eva, additional, Sheu, Ren-Dih, additional, Stewart, Robert, additional, Wheldon, Christopher, additional, O’Donnell, Riona, additional, Safer, Joshua D., additional, Sfakianos, John P., additional, Galsky, Matt D., additional, Liu, Tian, additional, Rosser, B. R. Simon, additional, Rosenstein, Barry, additional, Jackson, Andrew, additional, Lovelock, Michael, additional, Stock, Richard, additional, Goodman, Karyn A., additional, and Marshall, Deborah Catherine, additional
- Published
- 2024
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- View/download PDF
27. A data science approach for early-stage prediction of Patient's susceptibility to acute side effects of advanced radiotherapy
- Author
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Aldraimli, Mahmoud, Soria, Daniele, Grishchuck, Diana, Ingram, Samuel, Lyon, Robert, Mistry, Anil, Oliveira, Jorge, Samuel, Robert, Shelley, Leila E.A., Osman, Sarah, Dwek, Miriam V., Azria, David, Chang-Claude, Jenny, Gutiérrez-Enríquez, Sara, De Santis, Maria Carmen, Rosenstein, Barry S., De Ruysscher, Dirk, Sperk, Elena, Symonds, R. Paul, Stobart, Hilary, Vega, Ana, Veldeman, Liv, Webb, Adam, Talbot, Christopher J., West, Catharine M., Rattay, Tim, and Chaussalet, Thierry J.
- Published
- 2021
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- View/download PDF
28. Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants
- Author
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Dadaev, Tokhir, Saunders, Edward J, Newcombe, Paul J, Anokian, Ezequiel, Leongamornlert, Daniel A, Brook, Mark N, Cieza-Borrella, Clara, Mijuskovic, Martina, Wakerell, Sarah, Olama, Ali Amin Al, Schumacher, Fredrick R, Berndt, Sonja I, Benlloch, Sara, Ahmed, Mahbubl, Goh, Chee, Sheng, Xin, Zhang, Zhuo, Muir, Kenneth, Govindasami, Koveela, Lophatananon, Artitaya, Stevens, Victoria L, Gapstur, Susan M, Carter, Brian D, Tangen, Catherine M, Goodman, Phyllis, Thompson, Ian M, Batra, Jyotsna, Chambers, Suzanne, Moya, Leire, Clements, Judith, Horvath, Lisa, Tilley, Wayne, Risbridger, Gail, Gronberg, Henrik, Aly, Markus, Nordström, Tobias, Pharoah, Paul, Pashayan, Nora, Schleutker, Johanna, Tammela, Teuvo LJ, Sipeky, Csilla, Auvinen, Anssi, Albanes, Demetrius, Weinstein, Stephanie, Wolk, Alicja, Hakansson, Niclas, West, Catharine, Dunning, Alison M, Burnet, Neil, Mucci, Lorelei, Giovannucci, Edward, Andriole, Gerald, Cussenot, Olivier, Cancel-Tassin, Géraldine, Koutros, Stella, Freeman, Laura E Beane, Sorensen, Karina Dalsgaard, Orntoft, Torben Falck, Borre, Michael, Maehle, Lovise, Grindedal, Eli Marie, Neal, David E, Donovan, Jenny L, Hamdy, Freddie C, Martin, Richard M, Travis, Ruth C, Key, Tim J, Hamilton, Robert J, Fleshner, Neil E, Finelli, Antonio, Ingles, Sue Ann, Stern, Mariana C, Rosenstein, Barry, Kerns, Sarah, Ostrer, Harry, Lu, Yong-Jie, Zhang, Hong-Wei, Feng, Ninghan, Mao, Xueying, Guo, Xin, Wang, Guomin, Sun, Zan, Giles, Graham G, Southey, Melissa C, MacInnis, Robert J, FitzGerald, Liesel M, Kibel, Adam S, Drake, Bettina F, Vega, Ana, Gómez-Caamaño, Antonio, Fachal, Laura, Szulkin, Robert, Eklund, Martin, Kogevinas, Manolis, Llorca, Javier, Castaño-Vinyals, Gemma, Penney, Kathryn L, Stampfer, Meir, Park, Jong Y, and Sellers, Thomas A
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Genetics ,Aging ,Urologic Diseases ,Prostate Cancer ,Prevention ,Human Genome ,Cancer ,Clinical Research ,2.1 Biological and endogenous factors ,Aetiology ,Algorithms ,Bayes Theorem ,Black People ,Chromosome Mapping ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Humans ,Male ,Molecular Sequence Annotation ,Multivariate Analysis ,Polymorphism ,Single Nucleotide ,Prostatic Neoplasms ,Quantitative Trait Loci ,Risk ,White People ,PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium - Abstract
Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling.
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- 2018
29. Development of a method for generating SNP interaction-aware polygenic risk scores for radiotherapy toxicity
- Author
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Lievens, Yolande, van Eijkeren, Marc, Monten, Christel, De Neve, Wilfried, Peeters, Stephanie, Weltens, Caroline, Defraene, Gilles, van Limberghen, Erik, Briers, Erik, Bourgier, Celine, Draghici, Roxana, Bons, Francoise, Blaschke, Thomas, Weiß, Christian, Helmbold, Irmgard, Weißenberger, Christian, Stegmaier, Petra, Claßen, Johannes, Giesche, Ulrich, Sautter-Bihl, Marie-Luise, Neu, Burkhard, Schnabel, Thomas, Ehmann, Michael, Gauter-Fleckenstein, Benjamin, Schäfer, Jörg, Giandini, Tommaso, Franceschini, Marzia, Sangalli, Claudia, Morlino, Sara, Lozza, Laura, De Santis, Maria C., Pietro, Gabriele, Delmastro, Elena, Garibaldi, Elisabetta, Cicchetti, Alessandro, Piqué-Leiva, Bibiana, Molla, Meritxel, Giraldo, Alexandra, Ramos, Monica, Lobato-Busto, Ramon, Torrado Moya, Laura, Dominguez-Rios, Isabel, Fajardo-Paneque, Irene, Calvo-Crespo, Patricia, Carballo, Ana, Peleteiro, Paula, Olivia-Fuentes-Rios, Gomez-Caamano, Antonio, Harrop, Victoria, Payne, Debbie, Keni, Manjusha, Symonds, Paul R., Lavers, Samuel, Wright, Simon, Thiagarajan, Sridhar, Aznar-Garcia, Luis, Kancherla, Kiran, Kent, Christopher, Vasanthan, Subramaniam, Appleton, Donna, Kaushik, Monika, Kenny, Frances, Khout, Hazem, Krupa, Jaroslaw, Lambert, Kelly V., Pilgrim, Simon, Shokuhi, Sheila, Valassiadou, Kalliope, Bioangiu, Ion, Sampson, Kufre, Osman, Ahmed, Faivre-Finn, Corinne, Foweraker, Karen, Pascoe, Abigail, Esler, Claire P., Ward, Tim, Higginson, Daniel S., Green, Sheryl, Franco, Nicola Rares, Massi, Michela Carlotta, Ieva, Francesca, Manzoni, Andrea, Paganoni, Anna Maria, Zunino, Paolo, Veldeman, Liv, Ost, Piet, Fonteyne, Valérie, Talbot, Christopher J., Rattay, Tim, Webb, Adam, Johnson, Kerstie, Lambrecht, Maarten, Haustermans, Karin, De Meerleer, Gert, de Ruysscher, Dirk, Vanneste, Ben, Van Limbergen, Evert, Choudhury, Ananya, Elliott, Rebecca M., Sperk, Elena, Veldwijk, Marlon R., Herskind, Carsten, Avuzzi, Barbara, Noris Chiorda, Barbara, Valdagni, Riccardo, Azria, David, Farcy-Jacquet, Marie-Pierre, Brengues, Muriel, Rosenstein, Barry S., Stock, Richard G., Vega, Ana, Aguado-Barrera, Miguel E., Sosa-Fajardo, Paloma, Dunning, Alison M., Fachal, Laura, Kerns, Sarah L., Chang-Claude, Jenny, Seibold, Petra, West, Catharine M.L., and Rancati, Tiziana
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- 2021
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30. Survey of Radiation Oncologists to Assess Interest and Potential Use of a Genetic Test Predicting Susceptibility for the Development of Toxicities After Prostate Cancer Radiation Therapy
- Author
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Collado, Kayla, Kerns, Sarah L., Diefenbach, Michael A., Peterson-Roth, Elizabeth, Koski, Raymond, Ostrer, Harry, Stock, Richard G., Mattessich, Martin, Kaplan, Paul, and Rosenstein, Barry S.
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- 2020
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31. I-125 or Pd-103 for brachytherapy boost in men with high-risk prostate cancer: A comparison of survival and morbidity outcomes
- Author
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Stone, Nelson N., Skouteris, Vassilios M., Rosenstein, Barry S., and Stock, Richard G.
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- 2020
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32. Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis
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Yarmolinsky, James, primary, Robinson, Jamie W., additional, Mariosa, Daniela, additional, Karhunen, Ville, additional, Huang, Jian, additional, Dimou, Niki, additional, Murphy, Neil, additional, Burrows, Kimberley, additional, Bouras, Emmanouil, additional, Smith-Byrne, Karl, additional, Lewis, Sarah J., additional, Galesloot, Tessel E., additional, Kiemeney, Lambertus A., additional, Vermeulen, Sita, additional, Martin, Paul, additional, Albanes, Demetrius, additional, Hou, Lifang, additional, Newcomb, Polly A., additional, White, Emily, additional, Wolk, Alicja, additional, Wu, Anna H., additional, Le Marchand, Loïc, additional, Phipps, Amanda I., additional, Buchanan, Daniel D., additional, Zhao, Sizheng Steven, additional, Gill, Dipender, additional, Chanock, Stephen J., additional, Purdue, Mark P., additional, Davey Smith, George, additional, Brennan, Paul, additional, Herzig, Karl-Heinz, additional, Järvelin, Marjo-Riitta, additional, Amos, Chris I., additional, Hung, Rayjean J., additional, Dehghan, Abbas, additional, Johansson, Mattias, additional, Gunter, Marc J., additional, Tsilidis, Kostas K., additional, Martin, Richard M., additional, Landi, Maria Teresa, additional, Stevens, Victoria, additional, Wang, Ying, additional, Albanes, Demetrios, additional, Caporaso, Neil, additional, Amos, Christopher I., additional, Shete, Sanjay, additional, Bickeböller, Heike, additional, Risch, Angela, additional, Houlston, Richard, additional, Lam, Stephen, additional, Tardon, Adonina, additional, Chen, Chu, additional, Bojesen, Stig E., additional, Wichmann, H-Erich, additional, Christiani, David, additional, Rennert, Gadi, additional, Arnold, Susanne, additional, Field, John K., additional, Le Marchand, Loic, additional, Melander, Olle, additional, Brunnström, Hans, additional, Liu, Geoffrey, additional, Andrew, Angeline, additional, Shen, Hongbing, additional, Zienolddiny, Shan, additional, Grankvist, Kjell, additional, Johansson, Mikael, additional, Teare, M. Dawn, additional, Hong, Yun-Chul, additional, Yuan, Jian-Min, additional, Lazarus, Philip, additional, Schabath, Matthew B., additional, Aldrich, Melinda C., additional, Eeles, Rosalind A., additional, Haiman, Christopher A., additional, Kote-Jarai, Zsofia, additional, Schumacher, Fredrick R., additional, Benlloch, Sara, additional, Al Olama, Ali Amin, additional, Muir, Kenneth R., additional, Berndt, Sonja I., additional, Conti, David V., additional, Wiklund, Fredrik, additional, Chanock, Stephen, additional, Tangen, Catherine M., additional, Batra, Jyotsna, additional, Clements, Judith A., additional, Grönberg, Henrik, additional, Pashayan, Nora, additional, Schleutker, Johanna, additional, Weinstein, Stephanie J., additional, West, Catharine M.L., additional, Mucci, Lorelei A., additional, Cancel-Tassin, Géraldine, additional, Koutros, Stella, additional, Sørensen, Karina Dalsgaard, additional, Grindedal, Eli Marie, additional, Neal, David E., additional, Hamdy, Freddie C., additional, Donovan, Jenny L., additional, Travis, Ruth C., additional, Hamilton, Robert J., additional, Ingles, Sue Ann, additional, Rosenstein, Barry S., additional, Lu, Yong-Jie, additional, Giles, Graham G., additional, MacInnis, Robert J., additional, Kibel, Adam S., additional, Vega, Ana, additional, Kogevinas, Manolis, additional, Penney, Kathryn L., additional, Park, Jong Y., additional, Stanfrod, Janet L., additional, Cybulski, Cezary, additional, Nordestgaard, Børge G., additional, Nielsen, Sune F., additional, Brenner, Hermann, additional, Maier, Christiane, additional, Logothetis, Christopher J., additional, John, Esther M., additional, Teixeira, Manuel R., additional, Neuhausen, Susan L., additional, De Ruyck, Kim, additional, Razack, Azad, additional, Newcomb, Lisa F., additional, Lessel, Davor, additional, Kaneva, Radka, additional, Usmani, Nawaid, additional, Claessens, Frank, additional, Townsend, Paul A., additional, Castelao, Jose Esteban, additional, Roobol, Monique J., additional, Menegaux, Florence, additional, Khaw, Kay-Tee, additional, Cannon-Albright, Lisa, additional, Pandha, Hardev, additional, Thibodeau, Stephen N., additional, Hunter, David J., additional, Kraft, Peter, additional, Blot, William J., additional, and Riboli, Elio, additional
- Published
- 2024
- Full Text
- View/download PDF
33. Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
- Author
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Conti, David V., Darst, Burcu F., Moss, Lilit C., Saunders, Edward J., Sheng, Xin, Chou, Alisha, Schumacher, Fredrick R., Olama, Ali Amin Al, Benlloch, Sara, Dadaev, Tokhir, Brook, Mark N., Sahimi, Ali, Hoffmann, Thomas J., Takahashi, Atushi, Matsuda, Koichi, Momozawa, Yukihide, Fujita, Masashi, Muir, Kenneth, Lophatananon, Artitaya, Wan, Peggy, Le Marchand, Loic, Wilkens, Lynne R., Stevens, Victoria L., Gapstur, Susan M., Carter, Brian D., Schleutker, Johanna, Tammela, Teuvo L. J., Sipeky, Csilla, Auvinen, Anssi, Giles, Graham G., Southey, Melissa C., MacInnis, Robert J., Cybulski, Cezary, Wokołorczyk, Dominika, Lubiński, Jan, Neal, David E., Donovan, Jenny L., Hamdy, Freddie C., Martin, Richard M., Nordestgaard, Børge G., Nielsen, Sune F., Weischer, Maren, Bojesen, Stig E., Røder, Martin Andreas, Iversen, Peter, Batra, Jyotsna, Chambers, Suzanne, Moya, Leire, Horvath, Lisa, Clements, Judith A., Tilley, Wayne, Risbridger, Gail P., Gronberg, Henrik, Aly, Markus, Szulkin, Robert, Eklund, Martin, Nordström, Tobias, Pashayan, Nora, Dunning, Alison M., Ghoussaini, Maya, Travis, Ruth C., Key, Tim J., Riboli, Elio, Park, Jong Y., Sellers, Thomas A., Lin, Hui-Yi, Albanes, Demetrius, Weinstein, Stephanie J., Mucci, Lorelei A., Giovannucci, Edward, Lindstrom, Sara, Kraft, Peter, Hunter, David J., Penney, Kathryn L., Turman, Constance, Tangen, Catherine M., Goodman, Phyllis J., Thompson, Jr., Ian M., Hamilton, Robert J., Fleshner, Neil E., Finelli, Antonio, Parent, Marie-Élise, Stanford, Janet L., Ostrander, Elaine A., Geybels, Milan S., Koutros, Stella, Freeman, Laura E. Beane, Stampfer, Meir, Wolk, Alicja, Håkansson, Niclas, Andriole, Gerald L., Hoover, Robert N., Machiela, Mitchell J., Sørensen, Karina Dalsgaard, Borre, Michael, Blot, William J., Zheng, Wei, Yeboah, Edward D., Mensah, James E., Lu, Yong-Jie, Zhang, Hong-Wei, Feng, Ninghan, Mao, Xueying, Wu, Yudong, Zhao, Shan-Chao, Sun, Zan, Thibodeau, Stephen N., McDonnell, Shannon K., Schaid, Daniel J., West, Catharine M. L., Burnet, Neil, Barnett, Gill, Maier, Christiane, Schnoeller, Thomas, Luedeke, Manuel, Kibel, Adam S., Drake, Bettina F., Cussenot, Olivier, Cancel-Tassin, Géraldine, Menegaux, Florence, Truong, Thérèse, Koudou, Yves Akoli, John, Esther M., Grindedal, Eli Marie, Maehle, Lovise, Khaw, Kay-Tee, Ingles, Sue A., Stern, Mariana C., Vega, Ana, Gómez-Caamaño, Antonio, Fachal, Laura, Rosenstein, Barry S., Kerns, Sarah L., Ostrer, Harry, Teixeira, Manuel R., Paulo, Paula, Brandão, Andreia, Watya, Stephen, Lubwama, Alexander, Bensen, Jeannette T., Fontham, Elizabeth T. H., Mohler, James, Taylor, Jack A., Kogevinas, Manolis, Llorca, Javier, Castaño-Vinyals, Gemma, Cannon-Albright, Lisa, Teerlink, Craig C., Huff, Chad D., Strom, Sara S., Multigner, Luc, Blanchet, Pascal, Brureau, Laurent, Kaneva, Radka, Slavov, Chavdar, Mitev, Vanio, Leach, Robin J., Weaver, Brandi, Brenner, Hermann, Cuk, Katarina, Holleczek, Bernd, Saum, Kai-Uwe, Klein, Eric A., Hsing, Ann W., Kittles, Rick A., Murphy, Adam B., Logothetis, Christopher J., Kim, Jeri, Neuhausen, Susan L., Steele, Linda, Ding, Yuan Chun, Isaacs, William B., Nemesure, Barbara, Hennis, Anselm J. M., Carpten, John, Pandha, Hardev, Michael, Agnieszka, De Ruyck, Kim, De Meerleer, Gert, Ost, Piet, Xu, Jianfeng, Razack, Azad, Lim, Jasmine, Teo, Soo-Hwang, Newcomb, Lisa F., Lin, Daniel W., Fowke, Jay H., Neslund-Dudas, Christine, Rybicki, Benjamin A., Gamulin, Marija, Lessel, Davor, Kulis, Tomislav, Usmani, Nawaid, Singhal, Sandeep, Parliament, Matthew, Claessens, Frank, Joniau, Steven, Van den Broeck, Thomas, Gago-Dominguez, Manuela, Castelao, Jose Esteban, Martinez, Maria Elena, Larkin, Samantha, Townsend, Paul A., Aukim-Hastie, Claire, Bush, William S., Aldrich, Melinda C., Crawford, Dana C., Srivastava, Shiv, Cullen, Jennifer C., Petrovics, Gyorgy, Casey, Graham, Roobol, Monique J., Jenster, Guido, van Schaik, Ron H. N., Hu, Jennifer J., Sanderson, Maureen, Varma, Rohit, McKean-Cowdin, Roberta, Torres, Mina, Mancuso, Nicholas, Berndt, Sonja I., Van Den Eeden, Stephen K., Easton, Douglas F., Chanock, Stephen J., Cook, Michael B., Wiklund, Fredrik, Nakagawa, Hidewaki, Witte, John S., Eeles, Rosalind A., Kote-Jarai, Zsofia, and Haiman, Christopher A.
- Published
- 2021
- Full Text
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34. Observational and genetic associations between cardiorespiratory fitness and cancer : a UK Biobank and international consortia study
- Author
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Watts, Eleanor L., Gonzales, Tomas I., Strain, Tessa, Saint-Maurice, Pedro F., Bishop, D. Timothy, Chanock, Stephen J., Johansson, Mattias, Keku, Temitope O., Le Marchand, Loic, Moreno, Victor, Newcomb, Polly A., Newton, Christina C., Pai, Rish K., Purdue, Mark P., Ulrich, Cornelia M., Smith-Byrne, Karl, van Guelpen, Bethany, Eeles, Rosalind A., Haiman, Christopher A., Kote-Jarai, Zsofia, Schumacher, Fredrick R., Benlloch, Sara, Olama, Ali Amin Al, Muir, Kenneth R., Berndt, Sonja I., Conti, David V., Wiklund, Fredrik, Wang, Ying, Tangen, Catherine M., Batra, Jyotsna, Clements, Judith A., Grönberg, Henrik, Pashayan, Nora, Schleutker, Johanna, Albanes, Demetrius, Weinstein, Stephanie J., Wolk, Alicja, West, Catharine M. L., Mucci, Lorelei A., Cancel-Tassin, Géraldine, Koutros, Stella, Sørensen, Karina Dalsgaard, Grindedal, Eli Marie, Neal, David E., Hamdy, Freddie C., Donovan, Jenny L., Travis, Ruth C., Hamilton, Robert J., Ingles, Sue Ann, Rosenstein, Barry S., Lu, Yong-Jie, Giles, Graham G., MacInnis, Robert J., Kibel, Adam S., Vega, Ana, Kogevinas, Manolis, Penney, Kathryn L., Park, Jong Y., Stanford, Janet L., Cybulski, Cezary, Nordestgaard, Børge G., Nielsen, Sune F., Brenner, Hermann, Maier, Christiane, Kim, Jeri, John, Esther M., Teixeira, Manuel R., Neuhausen, Susan L., De Ruyck, Kim, Razack, Azad, Newcomb, Lisa F., Lessel, Davor, Kaneva, Radka, Usmani, Nawaid, Claessens, Frank, Townsend, Paul A., Castelao, Jose Esteban, Roobol, Monique J., Menegaux, Florence, Khaw, Kay-Tee, Cannon-Albright, Lisa, Pandha, Hardev, Thibodeau, Stephen N., Hunter, David J., Kraft, Peter, Blot, William J., Riboli, Elio, Day, Felix R., Wijndaele, Katrien, Wareham, Nicholas J., Matthews, Charles E., Moore, Steven C., Brage, Soren, Watts, Eleanor L., Gonzales, Tomas I., Strain, Tessa, Saint-Maurice, Pedro F., Bishop, D. Timothy, Chanock, Stephen J., Johansson, Mattias, Keku, Temitope O., Le Marchand, Loic, Moreno, Victor, Newcomb, Polly A., Newton, Christina C., Pai, Rish K., Purdue, Mark P., Ulrich, Cornelia M., Smith-Byrne, Karl, van Guelpen, Bethany, Eeles, Rosalind A., Haiman, Christopher A., Kote-Jarai, Zsofia, Schumacher, Fredrick R., Benlloch, Sara, Olama, Ali Amin Al, Muir, Kenneth R., Berndt, Sonja I., Conti, David V., Wiklund, Fredrik, Wang, Ying, Tangen, Catherine M., Batra, Jyotsna, Clements, Judith A., Grönberg, Henrik, Pashayan, Nora, Schleutker, Johanna, Albanes, Demetrius, Weinstein, Stephanie J., Wolk, Alicja, West, Catharine M. L., Mucci, Lorelei A., Cancel-Tassin, Géraldine, Koutros, Stella, Sørensen, Karina Dalsgaard, Grindedal, Eli Marie, Neal, David E., Hamdy, Freddie C., Donovan, Jenny L., Travis, Ruth C., Hamilton, Robert J., Ingles, Sue Ann, Rosenstein, Barry S., Lu, Yong-Jie, Giles, Graham G., MacInnis, Robert J., Kibel, Adam S., Vega, Ana, Kogevinas, Manolis, Penney, Kathryn L., Park, Jong Y., Stanford, Janet L., Cybulski, Cezary, Nordestgaard, Børge G., Nielsen, Sune F., Brenner, Hermann, Maier, Christiane, Kim, Jeri, John, Esther M., Teixeira, Manuel R., Neuhausen, Susan L., De Ruyck, Kim, Razack, Azad, Newcomb, Lisa F., Lessel, Davor, Kaneva, Radka, Usmani, Nawaid, Claessens, Frank, Townsend, Paul A., Castelao, Jose Esteban, Roobol, Monique J., Menegaux, Florence, Khaw, Kay-Tee, Cannon-Albright, Lisa, Pandha, Hardev, Thibodeau, Stephen N., Hunter, David J., Kraft, Peter, Blot, William J., Riboli, Elio, Day, Felix R., Wijndaele, Katrien, Wareham, Nicholas J., Matthews, Charles E., Moore, Steven C., and Brage, Soren
- Abstract
Background: The association of fitness with cancer risk is not clear. Methods: We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for risk of lung, colorectal, endometrial, breast, and prostate cancer in a subset of UK Biobank participants who completed a submaximal fitness test in 2009-12 (N = 72,572). We also investigated relationships using two-sample Mendelian randomisation (MR), odds ratios (ORs) were estimated using the inverse-variance weighted method. Results: After a median of 11 years of follow-up, 4290 cancers of interest were diagnosed. A 3.5 ml O2⋅min−1⋅kg−1 total-body mass increase in fitness (equivalent to 1 metabolic equivalent of task (MET), approximately 0.5 standard deviation (SD)) was associated with lower risks of endometrial (HR = 0.81, 95% CI: 0.73–0.89), colorectal (0.94, 0.90–0.99), and breast cancer (0.96, 0.92–0.99). In MR analyses, a 0.5 SD increase in genetically predicted O2⋅min−1⋅kg−1 fat-free mass was associated with a lower risk of breast cancer (OR = 0.92, 95% CI: 0.86–0.98). After adjusting for adiposity, both the observational and genetic associations were attenuated. Discussion: Higher fitness levels may reduce risks of endometrial, colorectal, and breast cancer, though relationships with adiposity are complex and may mediate these relationships. Increasing fitness, including via changes in body composition, may be an effective strategy for cancer prevention.
- Published
- 2024
- Full Text
- View/download PDF
35. Observational and genetic associations between cardiorespiratory fitness and cancer:a UK Biobank and international consortia study
- Author
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Watts, Eleanor L., Gonzales, Tomas I., Strain, Tessa, Saint-Maurice, Pedro F., Bishop, D. Timothy, Chanock, Stephen J., Johansson, Mattias, Keku, Temitope O., Le Marchand, Loic, Moreno, Victor, Newcomb, Polly A., Newton, Christina C., Pai, Rish K., Purdue, Mark P., Ulrich, Cornelia M., Smith-Byrne, Karl, Van Guelpen, Bethany, Eeles, Rosalind A., Haiman, Christopher A., Kote-Jarai, Zsofia, Schumacher, Fredrick R., Benlloch, Sara, Olama, Ali Amin Al, Muir, Kenneth R., Berndt, Sonja I., Conti, David V., Wiklund, Fredrik, Wang, Ying, Tangen, Catherine M., Batra, Jyotsna, Clements, Judith A., Grönberg, Henrik, Pashayan, Nora, Schleutker, Johanna, Albanes, Demetrius, Weinstein, Stephanie J., Wolk, Alicja, West, Catharine M.L., Mucci, Lorelei A., Cancel-Tassin, Géraldine, Koutros, Stella, Sørensen, Karina Dalsgaard, Grindedal, Eli Marie, Neal, David E., Hamdy, Freddie C., Donovan, Jenny L., Travis, Ruth C., Hamilton, Robert J., Ingles, Sue Ann, Rosenstein, Barry S., Lu, Yong Jie, Giles, Graham G., MacInnis, Robert J., Kibel, Adam S., Vega, Ana, Kogevinas, Manolis, Penney, Kathryn L., Park, Jong Y., Stanford, Janet L., Cybulski, Cezary, Nordestgaard, Børge G., Nielsen, Sune F., Brenner, Hermann, Maier, Christiane, Kim, Jeri, John, Esther M., Teixeira, Manuel R., Neuhausen, Susan L., De Ruyck, Kim, Razack, Azad, Newcomb, Lisa F., Lessel, Davor, Kaneva, Radka, Usmani, Nawaid, Claessens, Frank, Townsend, Paul A., Castelao, Jose Esteban, Roobol, Monique J., Menegaux, Florence, Khaw, Kay Tee, Cannon-Albright, Lisa, Pandha, Hardev, Thibodeau, Stephen N., Hunter, David J., Kraft, Peter, Blot, William J., Riboli, Elio, Day, Felix R., Wijndaele, Katrien, Wareham, Nicholas J., Matthews, Charles E., Moore, Steven C., Brage, Soren, Watts, Eleanor L., Gonzales, Tomas I., Strain, Tessa, Saint-Maurice, Pedro F., Bishop, D. Timothy, Chanock, Stephen J., Johansson, Mattias, Keku, Temitope O., Le Marchand, Loic, Moreno, Victor, Newcomb, Polly A., Newton, Christina C., Pai, Rish K., Purdue, Mark P., Ulrich, Cornelia M., Smith-Byrne, Karl, Van Guelpen, Bethany, Eeles, Rosalind A., Haiman, Christopher A., Kote-Jarai, Zsofia, Schumacher, Fredrick R., Benlloch, Sara, Olama, Ali Amin Al, Muir, Kenneth R., Berndt, Sonja I., Conti, David V., Wiklund, Fredrik, Wang, Ying, Tangen, Catherine M., Batra, Jyotsna, Clements, Judith A., Grönberg, Henrik, Pashayan, Nora, Schleutker, Johanna, Albanes, Demetrius, Weinstein, Stephanie J., Wolk, Alicja, West, Catharine M.L., Mucci, Lorelei A., Cancel-Tassin, Géraldine, Koutros, Stella, Sørensen, Karina Dalsgaard, Grindedal, Eli Marie, Neal, David E., Hamdy, Freddie C., Donovan, Jenny L., Travis, Ruth C., Hamilton, Robert J., Ingles, Sue Ann, Rosenstein, Barry S., Lu, Yong Jie, Giles, Graham G., MacInnis, Robert J., Kibel, Adam S., Vega, Ana, Kogevinas, Manolis, Penney, Kathryn L., Park, Jong Y., Stanford, Janet L., Cybulski, Cezary, Nordestgaard, Børge G., Nielsen, Sune F., Brenner, Hermann, Maier, Christiane, Kim, Jeri, John, Esther M., Teixeira, Manuel R., Neuhausen, Susan L., De Ruyck, Kim, Razack, Azad, Newcomb, Lisa F., Lessel, Davor, Kaneva, Radka, Usmani, Nawaid, Claessens, Frank, Townsend, Paul A., Castelao, Jose Esteban, Roobol, Monique J., Menegaux, Florence, Khaw, Kay Tee, Cannon-Albright, Lisa, Pandha, Hardev, Thibodeau, Stephen N., Hunter, David J., Kraft, Peter, Blot, William J., Riboli, Elio, Day, Felix R., Wijndaele, Katrien, Wareham, Nicholas J., Matthews, Charles E., Moore, Steven C., and Brage, Soren
- Abstract
Background: The association of fitness with cancer risk is not clear. Methods: We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for risk of lung, colorectal, endometrial, breast, and prostate cancer in a subset of UK Biobank participants who completed a submaximal fitness test in 2009-12 (N = 72,572). We also investigated relationships using two-sample Mendelian randomisation (MR), odds ratios (ORs) were estimated using the inverse-variance weighted method.Results: After a median of 11 years of follow-up, 4290 cancers of interest were diagnosed. A 3.5 ml O2⋅min−1⋅kg−1 total-body mass increase in fitness (equivalent to 1 metabolic equivalent of task (MET), approximately 0.5 standard deviation (SD)) was associated with lower risks of endometrial (HR = 0.81, 95% CI: 0.73–0.89), colorectal (0.94, 0.90–0.99), and breast cancer (0.96, 0.92–0.99). In MR analyses, a 0.5 SD increase in genetically predicted O2⋅min−1⋅kg−1 fat-free mass was associated with a lower risk of breast cancer (OR = 0.92, 95% CI: 0.86–0.98). After adjusting for adiposity, both the observational and genetic associations were attenuated. Discussion: Higher fitness levels may reduce risks of endometrial, colorectal, and breast cancer, though relationships with adiposity are complex and may mediate these relationships. Increasing fitness, including via changes in body composition, may be an effective strategy for cancer prevention.
- Published
- 2024
36. REQUITE: A prospective multicentre cohort study of patients undergoing radiotherapy for breast, lung or prostate cancer
- Author
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Lievens, Yolande, van Eijkeren, Marc, Vandecasteele, Katrien, Elhamin, Elhaseen, Ost, Piet, Fonteyne, Valérie, Swimberghe, Martijn, Deseyne, Pieter, De Neve, Wilfried, Duprez, Fréderic, Mareel, Marcus, Monten, Chris, Van Greveling, Annick, Vercauteren, Tom, Paelinck, Leen, Defraene, Gilles, Aerts, Rita, Arredouani, Soumia, Lambrecht, Maarten, Vanneste, Ben, Draghici, Roxana, Giordano, Frank, Herskind, Carsten, Veldwijk, Marlon, Helmbold, Irmgard, Giesche, Ulrich, Stegmaier, Petra, Weiß, Christian, Blaschke, Thomas, Neu, Burkhard, Lozza, Laura, Avuzzi, Barbara, Morlino, Sara, Sangalli, Claudia, Franceschini, Marzia, Rodriguez-Lage, Belina, Fernández-Tajes, Juan, Fuentes-Rios, Olivia, Domínguez-Rios, Isabel, Fajardo-Paneque, Irene, Sosa-Fajardo, Paloma, Torrado-Moya, Laura, Ramos-Albiac, Mónica, Giraldo, Alexandra, Altabas, Manolo, Piqué-Leiva, Bibiana, García-Relancio, David, Seoane-Ramallo, Alejandro, Lavers, Samuel, Wright, Simon, Dobbelaere, Hannah, Appleton, Donna, Kaushik, Monika, Kenny, Frances, Khout, Hazem, Krupa, Jaroslaw, Lambert, Kelly V., Pilgrim, Simon, Shokuhi, Sheila, Valassiadou, Kalliope, Aznar-Garcia, Luis, Boiangui, Ion, Kancherla, Kiran, Kent, Christopher, Sampson, Kufre, Osman, Ahmed, Sridhar, Thiagarajan, Vasanthan, Subramaniam, Faivre-Finn, Corinne, Harrop, Victoria, Keni, Manjusha, Foweraker, Karen, Pascoe, Abigail, Esler, Claire, Stock, Richard, Green, Sheryl, Golchin, Ava, Li, William, Seibold, Petra, Webb, Adam, Aguado-Barrera, Miguel E., Azria, David, Bourgier, Celine, Brengues, Muriel, Briers, Erik, Bultijnck, Renée, Calvo-Crespo, Patricia, Carballo, Ana, Choudhury, Ananya, Cicchetti, Alessandro, Claßen, Johannes, Delmastro, Elena, Dunning, Alison M., Elliott, Rebecca M., Fachal, Laura, Farcy-Jacquet, Marie-Pierre, Gabriele, Pietro, Garibaldi, Elisabetta, Gómez-Caamaño, Antonio, Gutiérrez-Enríquez, Sara, Higginson, Daniel S., Johnson, Kerstie, Lobato-Busto, Ramón, Mollà, Meritxell, Müller, Anusha, Payne, Debbie, Peleteiro, Paula, Post, Giselle, Rancati, Tiziana, Rattay, Tim, Reyes, Victoria, Rosenstein, Barry S., De Ruysscher, Dirk, De Santis, Maria Carmen, Schäfer, Jörg, Schnabel, Thomas, Sperk, Elena, Symonds, R. Paul, Stobart, Hilary, Taboada-Valladares, Begoña, Talbot, Christopher J., Valdagni, Riccardo, Vega, Ana, Veldeman, Liv, Ward, Tim, Weißenberger, Christian, West, Catharine M.L., and Chang-Claude, Jenny
- Published
- 2019
- Full Text
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37. Optimising Inter-Patient Image Registration for Image-Based Data Mining in Breast Radiotherapy
- Author
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Jaikuna, Tanwiwat, primary, Wilson, Fiona, additional, Azria, David, additional, Chang-Claude, Jenny, additional, De Santis, Maria Carmen, additional, Gutiérrez-Enríquez, Sara, additional, van Herk, Marcel, additional, Hoskin, Peter, additional, Kotzki, Lea, additional, Lambrecht, Maarten, additional, Seibold, Petra, additional, Seoane, Alejandro, additional, Sperk, Elena, additional, Symonds, R. Paul, additional, J Talbot, Christopher, additional, rancati, tiziana, additional, Rattay, Tim, additional, Reyes, Victoria, additional, Rosenstein, Barry S., additional, de Ruysscher, D., additional, Vega, Ana, additional, Veldeman, Liv, additional, Webb, Adam, additional, West, Catharine ML, additional, Aznar, Marianne Camille, additional, and Vasquez Osorio, Eliana, additional
- Published
- 2024
- Full Text
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38. Genetic Variants Predict Optimal Timing of Radiotherapy to Reduce Side-effects in Breast Cancer Patients
- Author
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Azria, David, Brookes, Anthony, Burr, Tom, Chang-Claude, Jenny, Davidson, Susan, De Ruysscher, Dirk, Dunning, Alison, Elliott, Rebecca, Gutiérrez Enríquez, Sara, Lambin, Philippe, Rancati, Tiziana, Rosenstein, Barry, Seibold, Petra, Symonds, R. Paul, Talbot, Chris, Thierens, Hubert, Valdagni, Riccardo, Vega, Ana, Veldeman, Liv, Wenz, Frederik, Yuille, Martin, West, Catharine, Johnson, K., Chang-Claude, J., Critchley, A.-M., Kyriacou, C., Lavers, S., Rattay, T., Seibold, P., Webb, A., West, C., Symonds, R.P., and Talbot, C.J.
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- 2019
- Full Text
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39. Radiogenomic Predictors of Adverse Effects following Charged Particle Therapy
- Author
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Morton, Lindsay M., Ricks-Santi, Luisel, West, Catharine M.L., and Rosenstein, Barry S.
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- 2018
- Full Text
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40. Delays in radiation therapy as a result of insurance peer-to-peer prior authorizations among lung cancer patients
- Author
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Salgado, Lucas Resende, Smith, William H., Nehlsen, Anthony, Sheu, Rendi, Saitta, Audrey, Dharmarajan, Kavita, Rosenstein, Barry, and Rosenzweig, Kenneth E.
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- 2019
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41. 1461: Prostate cancer patients with lower muscle mass have increased late toxicities post-radiotherapy.
- Author
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McWilliam, Alan, Shortall, Jane, Puri, Tanuj, Osorio, Eliana Vasquez, van Herk, Marcel, Choudhury, Ananya, Hoskin, Peter, Kerns, Sarah, Azria, David, Farcy-Jacquet, Marie-Pierre, Chang-Claude, Jenny, Dunning, Alison, Lambrecht, Maarten, Avuzzi, Barbara, de Ruysscher, Dirk, Seibold, Petra, Sperk, Elena, Talbot, Chris, Webb, Adam, Vega, Ana, Veldeman, Liv, Rosenstein, Barry, West, Catharine, and McSweeney, Donal
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- 2024
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42. 1378: Genetically-based analysis of dose surface maps for assessing toxicity post-RT: an innovative method
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Gioscio, Eliana, Massi, Michela Carlotta, Franco, Nicola Rares, Seibold, Petra, Avuzzi, Barbara, Cicchetti, Alessandro, Rosenstein, Barry, Azria, David, Choudhury, Ananya, De Ruysscher, Dirk, Lambrecht, Maarten, Sperk, Elena, Talbot, Christopher J., Vega, Ana, Veldeman, Liv, Webb, Adam, Zunino, Paolo, Paganoni, Anna Maria, Ieva, Francesca, Manzoni, Andrea, Kerns, Sarah L., Dunning, Alison, Chang-Claude, Jenny, West, Catharine M.L., and Rancati, Tiziana
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- 2024
- Full Text
- View/download PDF
43. 1242: Sensitivity of dose-response mapping model parameters at the bladder and rectum in prostate cancer
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Puri, Tanuj, van Herk, Marcel, osorio, Eliana Vasquez, Morros, Andrew P., Shortall, Jane, Kerns, Sarah L., Azria, David, Farcy-Jacquet, Marie-Pierre, Chang-Claude, Jenny, Dunning, Alison, Lambrecht, Maarten, Avuzzi, Barbara, de Ruysscher, Dirk, Seibold, Petra, Sperk, Elena, Talbot, Christopher, Vega, Ana, Veldeman, Liv, Webb, Adam, Rancati, Tiziana, Rosenstein, Barry, West, Catharine, Choudhury, Ananya, Hoskin, Peter, and McWilliam, Alan
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- 2024
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44. 2937: Dose deposition in sub-regions of breast relates to acute and persistent pain after radiotherapy
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Jaikuna, Tanwiwat, Wilson, Fiona, Azria, David, Chang-Claude, Jenny, De Santis, Maria Carmen, Enríquez, Sara Gutiérrez, van Herk, Marcel, Hoskin, Peter, Lambrecht, Maarten, Lingard, Zoe, Seibold, Petra, Sperk, Elena, Symonds, Paul R., Talbot, Christopher J., Rancati, Tiziana, Rattay, Tim, Reyes, Victoria, Rosenstein, Barry S., de Ruysscher, Dirk, Vega, Ana, Veldeman, Liv, Webb, Adam, West, Catharine M L, Vasquez-Osorio, Eliana, and Aznar, Marianne C.
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- 2024
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45. Radiation exposure, the ATM Gene, and contralateral breast cancer in the women's environmental cancer and radiation epidemiology study.
- Author
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Bernstein, Jonine L, Haile, Robert W, Stovall, Marilyn, Boice, John D, Shore, Roy E, Langholz, Bryan, Thomas, Duncan C, Bernstein, Leslie, Lynch, Charles F, Olsen, Jorgen H, Malone, Kathleen E, Mellemkjaer, Lene, Borresen-Dale, Anne-Lise, Rosenstein, Barry S, Teraoka, Sharon N, Diep, Anh T, Smith, Susan A, Capanu, Marinela, Reiner, Anne S, Liang, Xiaolin, Gatti, Richard A, Concannon, Patrick, and WECARE Study Collaborative Group
- Subjects
WECARE Study Collaborative Group ,Humans ,Breast Neoplasms ,Neoplasms ,Radiation-Induced ,Neoplasms ,Second Primary ,DNA Damage ,Radiation Injuries ,Genetic Predisposition to Disease ,Protein-Serine-Threonine Kinases ,Cell Cycle Proteins ,DNA-Binding Proteins ,Tumor Suppressor Proteins ,Odds Ratio ,Risk Assessment ,Risk Factors ,Case-Control Studies ,Environmental Exposure ,Age Factors ,Mutation ,Missense ,Time Factors ,International Cooperation ,Adult ,Aged ,Middle Aged ,Female ,Ataxia Telangiectasia Mutated Proteins ,Neoplasms ,Radiation-Induced ,Second Primary ,Mutation ,Missense ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
BackgroundIonizing radiation is a known mutagen and an established breast carcinogen. The ATM gene is a key regulator of cellular responses to the DNA damage induced by ionizing radiation. We investigated whether genetic variants in ATM play a clinically significant role in radiation-induced contralateral breast cancer in women.MethodsThe Women's Environmental, Cancer, and Radiation Epidemiology Study is an international population-based case-control study nested within a cohort of 52,536 survivors of unilateral breast cancer diagnosed between 1985 and 2000. The 708 case subjects were women with contralateral breast cancer, and the 1397 control subjects were women with unilateral breast cancer matched to the case subjects on age, follow-up time, registry reporting region, and race and/or ethnicity. All women were interviewed and underwent full mutation screening of the entire ATM gene. Complete medical treatment history information was collected, and for all women who received radiotherapy, the radiation dose to the contralateral breast was reconstructed using radiotherapy records and radiation measurements. Rate ratios (RRs) and corresponding 95% confidence intervals (CIs) were estimated by using multivariable conditional logistic regression. All P values are two-sided.ResultsAmong women who carried a rare ATM missense variant (ie, one carried by or =1.0 Gy: RR = 3.3, 95% CI = 1.4 to 8.0) or compared with unexposed women who carried the same predicted deleterious missense variant (0.01-0.99 Gy: RR = 5.3, 95% CI = 1.6 to 17.3; > or =1.0 Gy: RR = 5.8, 95% CI = 1.8 to 19.0; P(trend) = .044).ConclusionsWomen who carry rare deleterious ATM missense variants and who are treated with radiation may have an elevated risk of developing contralateral breast cancer. However, the rarity of these deleterious missense variants in human populations implies that ATM mutations could account for only a small portion of second primary breast cancers.
- Published
- 2010
46. Comparison of prone and supine positioning for breast cancer radiotherapy using REQUITE data: dosimetry, acute and two years physician and patient-reported outcomes
- Author
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Vakaet, Vincent, primary, Deseyne, Pieter, additional, Bultijnck, Renée, additional, Post, Giselle, additional, West, Catharine, additional, Azria, David, additional, Bourgier, Celine, additional, Farcy-Jacquet, Marie-Pierre, additional, Rosenstein, Barry, additional, Green, Sheryl, additional, de Ruysscher, Dirk, additional, Sperk, Elena, additional, Veldwijk, Marlon, additional, Herskind, Carsten, additional, De Santis, Maria Carmen, additional, Rancati, Tiziana, additional, Giandini, Tommaso, additional, Chang-Claude, Jenny, additional, Seibold, Petra, additional, Lambrecht, Maarten, additional, Weltens, Caroline, additional, Janssens, Hilde, additional, Vega, Ana, additional, Taboada-Valladares, Maria Begoña, additional, Aguado-Barrera, Miguel Elías, additional, Reyes, Victoria, additional, Altabas, Manuel, additional, Gutiérrez-Enríquez, Sara, additional, Monten, Christel, additional, Van Hulle, Hans, additional, and Veldeman, Liv, additional
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- 2023
- Full Text
- View/download PDF
47. Radiogenomics: Identification of Genomic Predictors for Radiation Toxicity
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Rosenstein, Barry S.
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- 2017
- Full Text
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48. Dose to the Contralateral Breast From Radiotherapy and Risk of Second Primary Breast Cancer in the WECARE Study
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Stovall, Marilyn, Smith, Susan A, Langholz, Bryan M, Boice, John D, Shore, Roy E, Andersson, Michael, Buchholz, Thomas A, Capanu, Marinela, Bernstein, Leslie, Lynch, Charles F, Malone, Kathleen E, Anton-Culver, Hoda, Haile, Robert W, Rosenstein, Barry S, Reiner, Anne S, Thomas, Duncan C, Bernstein, Jonine L, and Group, WECARE Study Collaborative
- Subjects
Clinical Research ,Breast Cancer ,Cancer ,7.3 Management and decision making ,Management of diseases and conditions ,Adult ,Body Burden ,Breast Neoplasms ,Denmark ,Female ,Humans ,Incidence ,Middle Aged ,Neoplasms ,Radiation-Induced ,Neoplasms ,Second Primary ,Radiotherapy ,Radiotherapy Dosage ,Relative Biological Effectiveness ,Risk Assessment ,Risk Factors ,Treatment Outcome ,United States ,Women's Health ,Contralateral breast ,Radiation risk ,Secondary breast cancer ,Women's Environmental ,Cancer ,and Radiation Epidemiology Study Collaborative Group ,Other Physical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
PurposeTo quantify the risk of second primary breast cancer in the contralateral breast (CB) after radiotherapy (RT) for first breast cancer.Methods and materialsThe study population included participants in the Women's Environmental, Cancer, and Radiation Epidemiology study: 708 cases (women with asynchronous bilateral breast cancer) and 1399 controls (women with unilateral breast cancer) counter-matched on radiation treatment. Participants were 1.0 Gy of absorbed dose to the specific quadrant of the CB had a 2.5-fold greater risk for CB cancer than unexposed women (RR = 2.5, 95% CI 1.4-4.5). No excess risk was observed in women >40 years of age. Women 5 years had a RR of 3.0 (95% CI 1.1-8.1), and the dose response was significant (excess RR per Gy of 1.0, 95% CI 0.1-3.0).ConclusionsWomen 1.0 Gy to the CB had an elevated, long-term risk of developing a second primary CB cancer. The risk is inversely related to age at exposure and is dose dependent.
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- 2008
49. Toward a Consensus on Radiobiology Teaching to Radiation Oncology Residents
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Dynlacht, Joseph R., Dewhirst, Mark W., Hall, Eric J., Rosenstein, Barry S., and Zeman, Elaine M.
- Published
- 2002
50. 11. Radiogenomics: Advancing Precision Radiation Oncology Through Development of a Genomic-Based Predictive Instrument
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Rosenstein, Barry S., primary
- Published
- 2019
- Full Text
- View/download PDF
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