Search

Your search keyword '"Rosenkranz, Alexander R."' showing total 818 results
Start Over Author "Rosenkranz, Alexander R."
818 results on '"Rosenkranz, Alexander R."'

1. Homocysteine contributes to atherogenic transformation of the aorta in rabbits in the absence of hypercholesterolemia

Author

Tehlivets, Oksana, Almer, Gunter, Brunner, Markus S., Lechleitner, Margarete, Sommer, Gerhard, Kolb, Dagmar, Leitinger, Gerd, Diwoky, Clemens, Wolinski, Heimo, Habisch, Hansjörg, Opriessnig, Peter, Bogoni, Francesca, Pernitsch, Dominique, Kavertseva, Maria, Bourgeois, Benjamin, Kukilo, Jelena, Tehlivets, Yuriy G., Schwarz, Andreas N., Züllig, Thomas, Bubalo, Vladimir, Schauer, Silvia, Groselj-Strele, Andrea, Hoefler, Gerald, Rechberger, Gerald N., Herrmann, Markus, Eller, Kathrin, Rosenkranz, Alexander R., Madl, Tobias, Frank, Saša, Holzapfel, Gerhard A., Kratky, Dagmar, Mangge, Harald, and Hörl, Gerd

Published
2024
Full Text
View/download PDF

2. Rescue Allocation Modes in Eurotransplant Kidney Transplantation: Recipient Oriented Extended Allocation Versus Competitive Rescue Allocation—A Retrospective Multicenter Outcome Analysis

Author

Assfalg, Volker, Miller, Gregor, Stocker, Felix, Hüser, Norbert, Hartmann, Daniel, Heemann, Uwe, Tieken, Ineke, Zanen, Wouter, Vogelaar, Serge, Rosenkranz, Alexander R., Schneeberger, Stefan, Függer, Reinhold, Berlakovich, Gabriela, Ysebaert, Dirk R., Jacobs-Tulleneers-Thevissen, Daniel, Mikhalski, Dimitri, van Laecke, Steven, Kuypers, Dirk, Mühlfeld, Anja S., Viebahn, Richard, Pratschke, Johann, Melchior, Sebastian, Hauser, Ingeborg A., Jänigen, Bernd, Weimer, Rolf, Richter, Nicolas, Foller, Susan, Schulte, Kevin, Kurschat, Christine, Harth, Ana, Moench, Christian, Rademacher, Sebastian, Nitschke, Martin, Krämer, Bernhard K., Renders, Lutz, Koliogiannis, Dionysios, Pascher, Andreas, Hoyer, Joachim, Weinmann-Menke, Julia, Schiffer, Mario, Banas, Bernhard, Hakenberg, Oliver, Schwenger, Vedat, Nadalin, Silvio, Lopau, Kai, Piros, Laszlo, Nemes, Balazs, Szakaly, Peter, Bouts, Antonia, Bemelman, Frederike J., Sanders, Jan S., de Vries, Aiko P. J., Christiaans, Maarten H. L., Hilbrands, Luuk, van Zuilen, Arjan D., Arnol, Miha, Stippel, Dirk, and Wahba, Roger

Published
2024
Full Text
View/download PDF

3. Antifungal prophylaxis for prevention of COVID-19-associated pulmonary aspergillosis in critically ill patients: an observational study

Author

Hatzl, Stefan, Reisinger, Alexander C, Posch, Florian, Prattes, Juergen, Stradner, Martin, Pilz, Stefan, Eller, Philipp, Schoerghuber, Michael, Toller, Wolfgang, Gorkiewicz, Gregor, Metnitz, Philipp, Rief, Martin, Prüller, Florian, Rosenkranz, Alexander R, Valentin, Thomas, Krause, Robert, Hoenigl, Martin, and Schilcher, Gernot

Subjects
Comparative Effectiveness Research, Lung, Clinical Research, Prevention, Clinical Trials and Supportive Activities, Respiratory, Infection, Good Health and Well Being, Aged, Antifungal Agents, COVID-19, Critical Illness, Female, Humans, Intensive Care Units, Male, Middle Aged, Pulmonary Aspergillosis, Respiratory Distress Syndrome, Triazoles, ICU, CAPA, COVID-19-associated aspergillosis, Posaconazole, Mould prophylaxis, Medical and Health Sciences, Emergency & Critical Care Medicine
Abstract

BackgroundCoronavirus disease 19 (COVID-19)-associated pulmonary aspergillosis (CAPA) emerged as important fungal complications in patients with COVID-19-associated severe acute respiratory failure (ARF). Whether mould active antifungal prophylaxis (MAFP) can prevent CAPA remains elusive so far.MethodsIn this observational study, we included all consecutive patients admitted to intensive care units with COVID-19-associated ARF between September 1, 2020, and May 1, 2021. We compared patients with versus without antifungal prophylaxis with respect to CAPA incidence (primary outcome) and mortality (secondary outcome). Propensity score adjustment was performed to account for any imbalances in baseline characteristics. CAPA cases were classified according to European Confederation of Medical Mycology (ECMM)/International Society of Human and Animal Mycoses (ISHAM) consensus criteria.ResultsWe included 132 patients, of whom 75 (57%) received antifungal prophylaxis (98% posaconazole). Ten CAPA cases were diagnosed, after a median of 6 days following ICU admission. Of those, 9 CAPA cases were recorded in the non-prophylaxis group and one in the prophylaxis group, respectively. However, no difference in 30-day ICU mortality could be observed. Thirty-day CAPA incidence estimates were 1.4% (95% CI 0.2-9.7) in the MAFP group and 17.5% (95% CI 9.6-31.4) in the group without MAFP (p = 0.002). The respective subdistributional hazard ratio (sHR) for CAPA incidence comparing the MAFP versus no MAFP group was of 0.08 (95% CI 0.01-0.63; p = 0.017).ConclusionIn ICU patients with COVID-19 ARF, antifungal prophylaxis was associated with significantly reduced CAPA incidence, but this did not translate into improved survival. Randomized controlled trials are warranted to evaluate the efficacy and safety of MAFP with respect to CAPA incidence and clinical outcomes.

Published
2021

5. Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline

Author

Gorski, Mathias, Jung, Bettina, Li, Yong, Matias-Garcia, Pamela R, Wuttke, Matthias, Coassin, Stefan, Thio, Chris HL, Kleber, Marcus E, Winkler, Thomas W, Wanner, Veronika, Chai, Jin-Fang, Chu, Audrey Y, Cocca, Massimiliano, Feitosa, Mary F, Ghasemi, Sahar, Hoppmann, Anselm, Horn, Katrin, Li, Man, Nutile, Teresa, Scholz, Markus, Sieber, Karsten B, Teumer, Alexander, Tin, Adrienne, Wang, Judy, Tayo, Bamidele O, Ahluwalia, Tarunveer S, Almgren, Peter, Bakker, Stephan JL, Banas, Bernhard, Bansal, Nisha, Biggs, Mary L, Boerwinkle, Eric, Bottinger, Erwin P, Brenner, Hermann, Carroll, Robert J, Chalmers, John, Chee, Miao-Li, Chee, Miao-Ling, Cheng, Ching-Yu, Coresh, Josef, de Borst, Martin H, Degenhardt, Frauke, Eckardt, Kai-Uwe, Endlich, Karlhans, Franke, Andre, Freitag-Wolf, Sandra, Gampawar, Piyush, Gansevoort, Ron T, Ghanbari, Mohsen, Gieger, Christian, Hamet, Pavel, Ho, Kevin, Hofer, Edith, Holleczek, Bernd, Foo, Valencia Hui Xian, Hutri-Kähönen, Nina, Hwang, Shih-Jen, Ikram, M Arfan, Josyula, Navya Shilpa, Kähönen, Mika, Khor, Chiea-Chuen, Koenig, Wolfgang, Kramer, Holly, Krämer, Bernhard K, Kühnel, Brigitte, Lange, Leslie A, Lehtimäki, Terho, Lieb, Wolfgang, Loos, Ruth JF, Lukas, Mary Ann, Lyytikäinen, Leo-Pekka, Meisinger, Christa, Meitinger, Thomas, Melander, Olle, Milaneschi, Yuri, Mishra, Pashupati P, Mononen, Nina, Mychaleckyj, Josyf C, Nadkarni, Girish N, Nauck, Matthias, Nikus, Kjell, Ning, Boting, Nolte, Ilja M, O’Donoghue, Michelle L, Orho-Melander, Marju, Pendergrass, Sarah A, Penninx, Brenda WJH, Preuss, Michael H, Psaty, Bruce M, Raffield, Laura M, Raitakari, Olli T, Rettig, Rainer, Rheinberger, Myriam, Rice, Kenneth M, Rosenkranz, Alexander R, Rossing, Peter, Rotter, Jerome I, Sabanayagam, Charumathi, Schmidt, Helena, and Schmidt, Reinhold

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Human Genome, Kidney Disease, Rare Diseases, Genetics, Aetiology, 2.1 Biological and endogenous factors, Renal and urogenital, AMP-Activated Protein Kinases, Creatinine, Genome-Wide Association Study, Glomerular Filtration Rate, Humans, Kidney, Protein Disulfide-Isomerases, United Kingdom, acute kidney injury, end-stage kidney disease, genome-wide association study, rapid eGFRcrea decline, Lifelines Cohort Study, Regeneron Genetics Center, Urology & Nephrology, Clinical sciences
Abstract

Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m2/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m2 at follow-up among those with eGFRcrea 60 mL/min/1.73m2 or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or LARP4B. Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.

Published
2021

6. Ruxolitinib, IV Immunoglobulin, and High-Dose Glucocorticoids for Critically Ill Adults With Secondary Hemophagocytic Lymphohistiocytosis: A Single-Center Observational Pilot Study

Author

Scholz, Laura, Posch, Florian, Schulz, Eduard, Gornicec, Max, Wölfler, Albert, Reisinger, Alexander C., Reinisch, Andreas, Eller, Philipp, Eisner, Florian, Kreuzer, Philipp, Stradner, Martin, Rosenkranz, Alexander R., Krammer, Florian, Schilcher, Gernot, Krause, Robert, and Hatzl, Stefan

Published
2024
Full Text
View/download PDF

7. Randomized Trial on the Effect of an Oral Spleen Tyrosine Kinase Inhibitor in the Treatment of IgA Nephropathy

Author

Tam, Frederick W.K., Tumlin, James, Barratt, Jonathan, Rovin, Brad H., Roberts, Ian S.D., Roufosse, Candice, Cook, H. Terence, Bhangal, Gurjeet, Brown, Alison L., Busch, Martin, Dudhiya, Fayaz, Duliege, Anne-Marie, Fraser, Donald J., Gale, Daniel P., Huang, Chiu-Ching, Lai, Ping-Chin, Lee, Meng, Masuda, Esteban S., McAdoo, Stephen P., Rosenkranz, Alexander R., Sommerer, Claudia, Sunder-Plassmann, Gere, Szeto, Cheuk-Chun, Tang, Sydney C.W., Williamson, Don E., Willcocks, Lisa, Vielhauer, Volker, Kim, Min Jeong, Todd, Leslie, Zayed, Hany, Tong-Starksen, Sandra, and Lafayette, Richard

Published
2023
Full Text
View/download PDF

8. Challenges in the management of the kidney allograft: from decline to failure: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Author

Ahn, Curie, Alberú, Josefina, Baliker, Mary, Bamgboye, Ebun L., Barber, Thelma, Bensouda, Melissa, Chadban, Steve J., Dadhania, Darshana M., Dębska-Ślizień, Alicja, Devresse, Arnaud, Ditzen, Beate, Fowler, Kevin, Gill, John S., Jha, Vivekanand, Khairallah, Pascale, Knoll, Greg A., Korst, Uwe, Lee, Austin, Legendre, Christophe, Lentine, Krista L., Lerma, Edgar V., Lorenz, Elizabeth C., Matas, Arthur J., Mohan, Sumit, Nazarewski, Sławomir, Noronha, Irene L., Obrador, Gregorio T., Parekh, Rulan S., Pavlakis, Martha, Pascual, Julio, Pilmore, Helen L., Rosenkranz, Alexander R., Rozen-Zvi, Benaya, Roy-Chaudhury, Prabir, Tanabe, Kazunari, Wanner, Christoph, Wasse, Haimanot, Yang, Chul-Woo, Josephson, Michelle A., Becker, Yolanda, Budde, Klemens, Kasiske, Bertram L., Kiberd, Bryce A., Loupy, Alexandre, Małyszko, Jolanta, Mannon, Roslyn B., Tönshoff, Burkhard, Cheung, Michael, Jadoul, Michel, Winkelmayer, Wolfgang C., and Zeier, Martin

Published
2023
Full Text
View/download PDF

12. Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies

Author

Gorski, Mathias, Rasheed, Humaira, Teumer, Alexander, Thomas, Laurent F., Graham, Sarah E., Sveinbjornsson, Gardar, Winkler, Thomas W., Günther, Felix, Stark, Klaus J., Chai, Jin-Fang, Tayo, Bamidele O., Wuttke, Matthias, Li, Yong, Tin, Adrienne, Ahluwalia, Tarunveer S., Ärnlöv, Johan, Åsvold, Bjørn Olav, Bakker, Stephan J.L., Banas, Bernhard, Bansal, Nisha, Biggs, Mary L., Biino, Ginevra, Böhnke, Michael, Boerwinkle, Eric, Bottinger, Erwin P., Brenner, Hermann, Brumpton, Ben, Carroll, Robert J., Chaker, Layal, Chalmers, John, Chee, Miao-Li, Chee, Miao-Ling, Cheng, Ching-Yu, Chu, Audrey Y., Ciullo, Marina, Cocca, Massimiliano, Cook, James P., Coresh, Josef, Cusi, Daniele, de Borst, Martin H., Degenhardt, Frauke, Eckardt, Kai-Uwe, Endlich, Karlhans, Evans, Michele K., Feitosa, Mary F., Franke, Andre, Freitag-Wolf, Sandra, Fuchsberger, Christian, Gampawar, Piyush, Gansevoort, Ron T., Ghanbari, Mohsen, Ghasemi, Sahar, Giedraitis, Vilmantas, Gieger, Christian, Gudbjartsson, Daniel F., Hallan, Stein, Hamet, Pavel, Hishida, Asahi, Ho, Kevin, Hofer, Edith, Holleczek, Bernd, Holm, Hilma, Hoppmann, Anselm, Horn, Katrin, Hutri-Kähönen, Nina, Hveem, Kristian, Hwang, Shih-Jen, Ikram, M. Arfan, Josyula, Navya Shilpa, Jung, Bettina, Kähönen, Mika, Karabegović, Irma, Khor, Chiea-Chuen, Koenig, Wolfgang, Kramer, Holly, Krämer, Bernhard K., Kühnel, Brigitte, Kuusisto, Johanna, Laakso, Markku, Lange, Leslie A., Lehtimäki, Terho, Li, Man, Lieb, Wolfgang, Lind, Lars, Lindgren, Cecilia M., Loos, Ruth J.F., Lukas, Mary Ann, Lyytikäinen, Leo-Pekka, Mahajan, Anubha, Matias-Garcia, Pamela R., Meisinger, Christa, Meitinger, Thomas, Melander, Olle, Milaneschi, Yuri, Mishra, Pashupati P., Mononen, Nina, Morris, Andrew P., Mychaleckyj, Josyf C., Nadkarni, Girish N., Naito, Mariko, Nakatochi, Masahiro, Nalls, Mike A., Nauck, Matthias, Nikus, Kjell, Ning, Boting, Nolte, Ilja M., Nutile, Teresa, O’Donoghue, Michelle L., O'Connell, Jeffrey, Olafsson, Isleifur, Orho-Melander, Marju, Parsa, Afshin, Pendergrass, Sarah A., Penninx, Brenda W.J.H., Pirastu, Mario, Preuss, Michael H., Psaty, Bruce M., Raffield, Laura M., Raitakari, Olli T., Rheinberger, Myriam, Rice, Kenneth M., Rizzi, Federica, Rosenkranz, Alexander R., Rossing, Peter, Rotter, Jerome I., Ruggiero, Daniela, Ryan, Kathleen A., Sabanayagam, Charumathi, Salvi, Erika, Schmidt, Helena, Schmidt, Reinhold, Scholz, Markus, Schöttker, Ben, Schulz, Christina-Alexandra, Sedaghat, Sanaz, Shaffer, Christian M., Sieber, Karsten B., Sim, Xueling, Sims, Mario, Snieder, Harold, Stanzick, Kira J., Thorsteinsdottir, Unnur, Stocker, Hannah, Strauch, Konstantin, Stringham, Heather M., Sulem, Patrick, Szymczak, Silke, Taylor, Kent D., Thio, Chris H.L., Tremblay, Johanne, Vaccargiu, Simona, van der Harst, Pim, van der Most, Peter J., Verweij, Niek, Völker, Uwe, Wakai, Kenji, Waldenberger, Melanie, Wallentin, Lars, Wallner, Stefan, Wang, Judy, Waterworth, Dawn M., White, Harvey D., Willer, Cristen J., Wong, Tien-Yin, Woodward, Mark, Yang, Qiong, Yerges-Armstrong, Laura M., Zimmermann, Martina, Zonderman, Alan B., Bergler, Tobias, Stefansson, Kari, Böger, Carsten A., Pattaro, Cristian, Köttgen, Anna, Kronenberg, Florian, and Heid, Iris M.

Published
2022
Full Text
View/download PDF

14. Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

Author

Winkler, Thomas W., Rasheed, Humaira, Teumer, Alexander, Gorski, Mathias, Rowan, Bryce X., Stanzick, Kira J., Thomas, Laurent F., Tin, Adrienne, Hoppmann, Anselm, Chu, Audrey Y., Tayo, Bamidele, Thio, Chris H. L., Cusi, Daniele, Chai, Jin-Fang, Sieber, Karsten B., Horn, Katrin, Li, Man, Scholz, Markus, Cocca, Massimiliano, Wuttke, Matthias, van der Most, Peter J., Yang, Qiong, Ghasemi, Sahar, Nutile, Teresa, Li, Yong, Pontali, Giulia, Günther, Felix, Dehghan, Abbas, Correa, Adolfo, Parsa, Afshin, Feresin, Agnese, de Vries, Aiko P. J., Zonderman, Alan B., Smith, Albert V., Oldehinkel, Albertine J., De Grandi, Alessandro, Rosenkranz, Alexander R., Franke, Andre, Teren, Andrej, Metspalu, Andres, Hicks, Andrew A., Morris, Andrew P., Tönjes, Anke, Morgan, Anna, Podgornaia, Anna I., Peters, Annette, Körner, Antje, Mahajan, Anubha, Campbell, Archie, Freedman, Barry I., Spedicati, Beatrice, Ponte, Belen, Schöttker, Ben, Brumpton, Ben, Banas, Bernhard, Krämer, Bernhard K., Jung, Bettina, Åsvold, Bjørn Olav, Smith, Blair H., Ning, Boting, Penninx, Brenda W. J. H., Vanderwerff, Brett R., Psaty, Bruce M., Kammerer, Candace M., Langefeld, Carl D., Hayward, Caroline, Spracklen, Cassandra N., Robinson-Cohen, Cassianne, Hartman, Catharina A., Lindgren, Cecilia M., Wang, Chaolong, Sabanayagam, Charumathi, Heng, Chew-Kiat, Lanzani, Chiara, Khor, Chiea-Chuen, Cheng, Ching-Yu, Fuchsberger, Christian, Gieger, Christian, Shaffer, Christian M., Schulz, Christina-Alexandra, Willer, Cristen J., Chasman, Daniel I., Gudbjartsson, Daniel F., Ruggiero, Daniela, Toniolo, Daniela, Czamara, Darina, Porteous, David J., Waterworth, Dawn M., Mascalzoni, Deborah, Mook-Kanamori, Dennis O., Reilly, Dermot F., Daw, E. Warwick, Hofer, Edith, Boerwinkle, Eric, Salvi, Erika, Bottinger, Erwin P., Tai, E-Shyong, Catamo, Eulalia, Rizzi, Federica, Guo, Feng, Rivadeneira, Fernando, Guilianini, Franco, Sveinbjornsson, Gardar, Ehret, Georg, Waeber, Gerard, Biino, Ginevra, Girotto, Giorgia, Pistis, Giorgio, Nadkarni, Girish N., Delgado, Graciela E., Montgomery, Grant W., Snieder, Harold, Campbell, Harry, White, Harvey D., Gao, He, Stringham, Heather M., Schmidt, Helena, Li, Hengtong, Brenner, Hermann, Holm, Hilma, Kirsten, Holgen, Kramer, Holly, Rudan, Igor, Nolte, Ilja M., Tzoulaki, Ioanna, Olafsson, Isleifur, Martins, Jade, Cook, James P., Wilson, James F., Halbritter, Jan, Felix, Janine F., Divers, Jasmin, Kooner, Jaspal S., Lee, Jeannette Jen-Mai, O’Connell, Jeffrey, Rotter, Jerome I., Liu, Jianjun, Xu, Jie, Thiery, Joachim, Ärnlöv, Johan, Kuusisto, Johanna, Jakobsdottir, Johanna, Tremblay, Johanne, Chambers, John C., Whitfield, John B., Gaziano, John M., Marten, Jonathan, Coresh, Josef, Jonas, Jost B., Mychaleckyj, Josyf C., Christensen, Kaare, Eckardt, Kai-Uwe, Mohlke, Karen L., Endlich, Karlhans, Dittrich, Katalin, Ryan, Kathleen A., Rice, Kenneth M., Taylor, Kent D., Ho, Kevin, Nikus, Kjell, Matsuda, Koichi, Strauch, Konstantin, Miliku, Kozeta, Hveem, Kristian, Lind, Lars, Wallentin, Lars, Yerges-Armstrong, Laura M., Raffield, Laura M., Phillips, Lawrence S., Launer, Lenore J., Lyytikäinen, Leo-Pekka, Lange, Leslie A., Citterio, Lorena, Klaric, Lucija, Ikram, M. Arfan, Ising, Marcus, Kleber, Marcus E., Francescatto, Margherita, Concas, Maria Pina, Ciullo, Marina, Piratsu, Mario, Orho-Melander, Marju, Laakso, Markku, Loeffler, Markus, Perola, Markus, de Borst, Martin H., Gögele, Martin, Bianca, Martina La, Lukas, Mary Ann, Feitosa, Mary F., Biggs, Mary L., Wojczynski, Mary K., Kavousi, Maryam, Kanai, Masahiro, Akiyama, Masato, Yasuda, Masayuki, Nauck, Matthias, Waldenberger, Melanie, Chee, Miao-Li, Chee, Miao-Ling, Boehnke, Michael, Preuss, Michael H., Stumvoll, Michael, Province, Michael A., Evans, Michele K., O’Donoghue, Michelle L., Kubo, Michiaki, Kähönen, Mika, Kastarinen, Mika, Nalls, Mike A., Kuokkanen, Mikko, Ghanbari, Mohsen, Bochud, Murielle, Josyula, Navya Shilpa, Martin, Nicholas G., Tan, Nicholas Y. Q., Palmer, Nicholette D., Pirastu, Nicola, Schupf, Nicole, Verweij, Niek, Hutri-Kähönen, Nina, Mononen, Nina, Bansal, Nisha, Devuyst, Olivier, Melander, Olle, Raitakari, Olli T., Polasek, Ozren, Manunta, Paolo, Gasparini, Paolo, Mishra, Pashupati P., Sulem, Patrick, Magnusson, Patrik K. E., Elliott, Paul, Ridker, Paul M., Hamet, Pavel, Svensson, Per O., Joshi, Peter K., Kovacs, Peter, Pramstaller, Peter P., Rossing, Peter, Vollenweider, Peter, van der Harst, Pim, Dorajoo, Rajkumar, Sim, Ralene Z. H., Burkhardt, Ralph, Tao, Ran, Noordam, Raymond, Mägi, Reedik, Schmidt, Reinhold, de Mutsert, Renée, Rueedi, Rico, van Dam, Rob M., Carroll, Robert J., Gansevoort, Ron T., Loos, Ruth J. F., Felicita, Sala Cinzia, Sedaghat, Sanaz, Padmanabhan, Sandosh, Freitag-Wolf, Sandra, Pendergrass, Sarah A., Graham, Sarah E., Gordon, Scott D., Hwang, Shih-Jen, Kerr, Shona M., Vaccargiu, Simona, Patil, Snehal B., Hallan, Stein, Bakker, Stephan J. L., Lim, Su-Chi, Lucae, Susanne, Vogelezang, Suzanne, Bergmann, Sven, Corre, Tanguy, Ahluwalia, Tarunveer S., Lehtimäki, Terho, Boutin, Thibaud S., Meitinger, Thomas, Wong, Tien-Yin, Bergler, Tobias, Rabelink, Ton J., Esko, Tõnu, Haller, Toomas, Thorsteinsdottir, Unnur, Völker, Uwe, Foo, Valencia Hui Xian, Salomaa, Veikko, Vitart, Veronique, Giedraitis, Vilmantas, Gudnason, Vilmundur, Jaddoe, Vincent W. V., Huang, Wei, Zhang, Weihua, Wei, Wen Bin, Kiess, Wieland, März, Winfried, Koenig, Wolfgang, Lieb, Wolfgang, Gao, Xin, Sim, Xueling, Wang, Ya Xing, Friedlander, Yechiel, Tham, Yih-Chung, Kamatani, Yoichiro, Okada, Yukinori, Milaneschi, Yuri, Yu, Zhi, Stark, Klaus J., Stefansson, Kari, Böger, Carsten A., Hung, Adriana M., Kronenberg, Florian, Köttgen, Anna, Pattaro, Cristian, and Heid, Iris M.

Published
2022
Full Text
View/download PDF

15. Pre-Transplant Frequencies of FoxP3+CD25+ in CD3+CD8+ T Cells as Potential Predictors for CMV in CMV-Intermediate Risk Kidney Transplant Recipients

Author

Mooslechner, Agnes A., primary, Schuller, Max, additional, Pfeifer, Verena, additional, Klötzer, Konstantin A., additional, Prietl, Barbara, additional, Kirsch, Alexander H., additional, Stiegler, Philipp, additional, Sucher, Robert, additional, Sourij, Harald, additional, Rosenkranz, Alexander R., additional, and Eller, Kathrin, additional

Published
2024
Full Text
View/download PDF

18. Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline

Author

Alizadeh, Behrooz Z., Boezen, H. Marike, Franke, Lude, van der Harst, Pim, Navis, Gerjan, Rots, Marianne, Snieder, Harold, Swertz, Morris, Wolffenbuttel, Bruce H.R., Wijmenga, Cisca, Abecasis, Goncalo, Baras, Aris, Cantor, Michael, Coppola, Giovanni, Economides, Aris, Lotta, Luca A., Overton, John D., Reid, Jeffrey G., Shuldiner, Alan, Beechert, Christina, Forsythe, Caitlin, Fuller, Erin D., Gu, Zhenhua, Lattari, Michael, Lopez, Alexander, Schleicher, Thomas D., Padilla, Maria Sotiropoulos, Toledo, Karina, Widom, Louis, Wolf, Sarah E., Pradhan, Manasi, Manoochehri, Kia, Ulloa, Ricardo H., Bai, Xiaodong, Balasubramanian, Suganthi, Barnard, Leland, Blumenfeld, Andrew, Eom, Gisu, Habegger, Lukas, Hawes, Alicia, Khalid, Shareef, Maxwell, Evan K., Salerno, William, Staples, Jeffrey C., Jones, Marcus B., Mitnaul, Lyndon J., Gorski, Mathias, Jung, Bettina, Li, Yong, Matias-Garcia, Pamela R., Wuttke, Matthias, Coassin, Stefan, Thio, Chris H.L., Kleber, Marcus E., Winkler, Thomas W., Wanner, Veronika, Chai, Jin-Fang, Chu, Audrey Y., Cocca, Massimiliano, Feitosa, Mary F., Ghasemi, Sahar, Hoppmann, Anselm, Horn, Katrin, Li, Man, Nutile, Teresa, Scholz, Markus, Sieber, Karsten B., Teumer, Alexander, Tin, Adrienne, Wang, Judy, Tayo, Bamidele O., Ahluwalia, Tarunveer S., Almgren, Peter, Bakker, Stephan J.L., Banas, Bernhard, Bansal, Nisha, Biggs, Mary L., Boerwinkle, Eric, Bottinger, Erwin P., Brenner, Hermann, Carroll, Robert J., Chalmers, John, Chee, Miao-Li, Chee, Miao-Ling, Cheng, Ching-Yu, Coresh, Josef, de Borst, Martin H., Degenhardt, Frauke, Eckardt, Kai-Uwe, Endlich, Karlhans, Franke, Andre, Freitag-Wolf, Sandra, Gampawar, Piyush, Gansevoort, Ron T., Ghanbari, Mohsen, Gieger, Christian, Hamet, Pavel, Ho, Kevin, Hofer, Edith, Holleczek, Bernd, Xian Foo, Valencia Hui, Hutri-Kähönen, Nina, Hwang, Shih-Jen, Ikram, M. Arfan, Josyula, Navya Shilpa, Kähönen, Mika, Khor, Chiea-Chuen, Koenig, Wolfgang, Kramer, Holly, Krämer, Bernhard K., Kühnel, Brigitte, Lange, Leslie A., Lehtimäki, Terho, Lieb, Wolfgang, Loos, Ruth J.F., Lukas, Mary Ann, Lyytikäinen, Leo-Pekka, Meisinger, Christa, Meitinger, Thomas, Melander, Olle, Milaneschi, Yuri, Mishra, Pashupati P., Mononen, Nina, Mychaleckyj, Josyf C., Nadkarni, Girish N., Nauck, Matthias, Nikus, Kjell, Ning, Boting, Nolte, Ilja M., O’Donoghue, Michelle L., Orho-Melander, Marju, Pendergrass, Sarah A., Penninx, Brenda W.J.H., Preuss, Michael H., Psaty, Bruce M., Raffield, Laura M., Raitakari, Olli T., Rettig, Rainer, Rheinberger, Myriam, Rice, Kenneth M., Rosenkranz, Alexander R., Rossing, Peter, Rotter, Jerome I., Sabanayagam, Charumathi, Schmidt, Helena, Schmidt, Reinhold, Schöttker, Ben, Schulz, Christina-Alexandra, Sedaghat, Sanaz, Shaffer, Christian M., Strauch, Konstantin, Szymczak, Silke, Taylor, Kent D., Tremblay, Johanne, Chaker, Layal, van der Most, Peter J., Verweij, Niek, Völker, Uwe, Waldenberger, Melanie, Wallentin, Lars, Waterworth, Dawn M., White, Harvey D., Wilson, James G., Wong, Tien-Yin, Woodward, Mark, Yang, Qiong, Yasuda, Masayuki, Yerges-Armstrong, Laura M., Zhang, Yan, Wanner, Christoph, Böger, Carsten A., Köttgen, Anna, Kronenberg, Florian, Pattaro, Cristian, and Heid, Iris M.

Published
2021
Full Text
View/download PDF

20. Rescue Allocation Modes in Eurotransplant Kidney Transplantation: Recipient Oriented Extended Allocation Versus Competitive Rescue Allocation-A Retrospective Multicenter Outcome Analysis

Author

MS Nefrologie, Circulatory Health, Assfalg, Volker, Miller, Gregor, Stocker, Felix, Hüser, Norbert, Hartmann, Daniel, Heemann, Uwe, Tieken, Ineke, Zanen, Wouter, Vogelaar, Serge, Rosenkranz, Alexander R, Schneeberger, Stefan, Függer, Reinhold, Berlakovich, Gabriela, Ysebaert, Dirk R, Jacobs-Tulleneers-Thevissen, Daniel, Mikhalski, Dimitri, van Laecke, Steven, Kuypers, Dirk, Mühlfeld, Anja S, Viebahn, Richard, Pratschke, Johann, Melchior, Sebastian, Hauser, Ingeborg A, Jänigen, Bernd, Weimer, Rolf, Richter, Nicolas, Foller, Susan, Schulte, Kevin, Kurschat, Christine, Harth, Ana, Moench, Christian, Rademacher, Sebastian, Nitschke, Martin, Krämer, Bernhard K, Renders, Lutz, Koliogiannis, Dionysios, Pascher, Andreas, Hoyer, Joachim, Weinmann-Menke, Julia, Schiffer, Mario, Banas, Bernhard, Hakenberg, Oliver, Schwenger, Vedat, Nadalin, Silvio, Lopau, Kai, Piros, Laszlo, Nemes, Balazs, Szakaly, Peter, Bouts, Antonia, Bemelman, Frederike J, Sanders, Jan S, de Vries, Aiko P J, Christiaans, Maarten H L, Hilbrands, Luuk, van Zuilen, Arjan D, Arnol, Miha, Stippel, Dirk, Wahba, Roger, MS Nefrologie, Circulatory Health, Assfalg, Volker, Miller, Gregor, Stocker, Felix, Hüser, Norbert, Hartmann, Daniel, Heemann, Uwe, Tieken, Ineke, Zanen, Wouter, Vogelaar, Serge, Rosenkranz, Alexander R, Schneeberger, Stefan, Függer, Reinhold, Berlakovich, Gabriela, Ysebaert, Dirk R, Jacobs-Tulleneers-Thevissen, Daniel, Mikhalski, Dimitri, van Laecke, Steven, Kuypers, Dirk, Mühlfeld, Anja S, Viebahn, Richard, Pratschke, Johann, Melchior, Sebastian, Hauser, Ingeborg A, Jänigen, Bernd, Weimer, Rolf, Richter, Nicolas, Foller, Susan, Schulte, Kevin, Kurschat, Christine, Harth, Ana, Moench, Christian, Rademacher, Sebastian, Nitschke, Martin, Krämer, Bernhard K, Renders, Lutz, Koliogiannis, Dionysios, Pascher, Andreas, Hoyer, Joachim, Weinmann-Menke, Julia, Schiffer, Mario, Banas, Bernhard, Hakenberg, Oliver, Schwenger, Vedat, Nadalin, Silvio, Lopau, Kai, Piros, Laszlo, Nemes, Balazs, Szakaly, Peter, Bouts, Antonia, Bemelman, Frederike J, Sanders, Jan S, de Vries, Aiko P J, Christiaans, Maarten H L, Hilbrands, Luuk, van Zuilen, Arjan D, Arnol, Miha, Stippel, Dirk, and Wahba, Roger

Published
2024

21. Targeting Calcitriol Metabolism in Acute Vitamin D Toxicity—A Comprehensive Review and Clinical Insight.

Author

Aberger, Simon, Schreiber, Nikolaus, Pilz, Stefan, Eller, Kathrin, Rosenkranz, Alexander R., and Kirsch, Alexander H.

Subjects
VITAMIN D, VITAMIN D metabolism, DIETARY supplements, LITERATURE reviews, CALCITRIOL
Abstract

High-dose vitamin D supplementation is common in the general population, but unsupervised high-dose supplementation in vitamin D-replete individuals poses a risk of severe toxicity. Susceptibility to vitamin D toxicity shows a significant inter-individual variability that may in part be explained by genetic predispositions (i.e., CYP24A1 polymorphism). The classic manifestation of vitamin D toxicity is hypercalcemia, which may be refractory to conventional therapy. Its causes include the endogenous overaction of 1α-hydroxylase, monogenic alterations affecting vitamin D metabolizing enzymes and exogenous vitamin D intoxication. In this manuscript, we include a literature review of potential pharmacological interventions targeting calcitriol metabolism to treat vitamin D intoxication and present a case of severe, exogenous vitamin D intoxication responding to systemic corticosteroids after the failure of conventional therapy. Systemic glucocorticoids alleviate acute hypercalcemia by inhibiting enteric calcium absorption and increasing the degradation of vitamin D metabolites but may cause adverse effects. Inhibitors of 1α-hydroxylase (keto/fluconazole) and inducers of CYP3A4 (rifampicin) may be considered steroid-sparing alternatives for the treatment of vitamin D intoxication. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

24. Glucagon-Like Peptide-1 Receptor Agonism Improves Nephrotoxic Serum Nephritis by Inhibiting T-Cell Proliferation

Author

Moschovaki Filippidou, Foteini, Kirsch, Alexander H., Thelen, Matthias, Kétszeri, Máté, Artinger, Katharina, Aringer, Ida, Schabhüttl, Corinna, Mooslechner, Agnes A., Frauscher, Bianca, Pollheimer, Marion, Niedrist, Tobias, Meinitzer, Andreas, Drucker, Daniel J., Pieber, Thomas R., Eller, Philipp, Rosenkranz, Alexander R., Heinemann, Akos, and Eller, Kathrin

Published
2020
Full Text
View/download PDF

26. Kidney Transplantation after Rescue Allocation - the Eurotransplant Experience: A Retrospective Multicenter Outcome Analysis

Author

Assfalg, Volker, Miller, Gregor, Stocker, Felix, van Meel, Marieke, Groenevelt, Tiny, Tieken, Ineke, Ankerst, Donna, Renders, Lutz, Novotny, Alexander, Hartmann, Daniel, Jell, Alissa, Rahmel, Axel, Wahba, Roger, Muehlfeld, Anja, Antonia, Bouts, Ysebaert, Dirk, Globke, Brigitta, Jacobs-Tulleneers-Thevissen, Daniel, Piros, László, Stippel, Dirk, Heller, Katharina, Eisenberger, Ute, van Laecke, Steven, Weimer, Rolf, Rosenkranz, Alexander R., Berger, Stefan, Fischer, Lutz, Kliem, Volker, Vondran, Florian, Sester, Urban, Schneeberger, Stefan, Harth, Ana, Kuypers, Dirk, Függer, Reinhold, Arnol, Miha, Christiaans, Maarten, Weinmann-Menke, Julia, Krüger, Bernd, Hilbrands, Luuk, Banas, Bernhard, Hakenberg, Oliver, Minnee, Robert, Schwenger, Vedat, Heyne, Nils, van Zuilen, Arjan, Reindl-Schwaighofer, Roman, Lopau, Kai, Huüser, Norbert, and Heemann, Uwe

Published
2021
Full Text
View/download PDF

28. Convalescent plasma therapy and mortality in COVID-19 patients admitted to the ICU: a prospective observational study

Author

Hatzl, Stefan, Posch, Florian, Sareban, Nazanin, Stradner, Martin, Rosskopf, Konrad, Reisinger, Alexander C., Eller, Philipp, Schörghuber, Michael, Toller, Wolfgang, Sloup, Zdenka, Prüller, Florian, Gütl, Katharina, Pilz, Stefan, Rosenkranz, Alexander R., Greinix, Hildegard T., Krause, Robert, Schlenke, Peter, and Schilcher, Gernot

Published
2021
Full Text
View/download PDF

29. MicroRNA-142-3p improves vascular relaxation in uremia

Author

Kétszeri, Máté, Kirsch, Andrijana, Frauscher, Bianca, Moschovaki-Filippidou, Foteini, Mooslechner, Agnes A., Kirsch, Alexander H., Schabhuettl, Corinna, Aringer, Ida, Artinger, Katharina, Pregartner, Gudrun, Ekart, Robert, Breznik, Silva, Hojs, Radovan, Goessler, Walter, Schilcher, Irene, Müller, Helmut, Obermayer-Pietsch, Barbara, Frank, Saša, Rosenkranz, Alexander R., Eller, Philipp, and Eller, Kathrin

Published
2019
Full Text
View/download PDF

30. Pre-Transplant Frequencies of FoxP3+CD25+ in CD3+CD8+ T Cells as Potential Predictors for CMV in CMV-Intermediate Risk Kidney Transplant Recipients.

Author

Mooslechner, Agnes A., Schuller, Max, Pfeifer, Verena, Klötzer, Konstantin A., Prietl, Barbara, Kirsch, Alexander H., Stiegler, Philipp, Sucher, Robert, Sourij, Harald, Rosenkranz, Alexander R., and Eller, Kathrin

Subjects
T cells, KIDNEY transplantation, MONONUCLEAR leukocytes, CYTOMEGALOVIRUS diseases
Abstract

Cytomegalovirus (CMV) infection detrimentally influences graft survival in kidney transplant recipients, with the risk primarily determined by recipient and donor serostatus. However, recipient CD8+ T cells play a crucial role in CMV control. The optimal preventive strategy (prophylaxis vs. pre-emptive treatment), particularly for seropositive (intermediate risk) recipients, remains uncertain. We investigated CD8+ T cell subpopulation dynamics and CMV occurrence (DNAemia ≥ 100 IU/mL) in 65 kidney transplant recipients, collecting peripheral blood mononuclear cells before (T1) and 1 year after transplantation (T2). Comparing the two timepoints, we found an increase in granulocyte, monocyte and CD3+CD8+ T cells numbers, while FoxP3+CD25+, LAG-3+ and PD-1+ frequencies were reduced at T2. CMV DNAemia occurred in 33 recipients (55.8%) during the first year. Intermediate risk patients were disproportionally affected by posttransplant CMV (N = 29/ 45, 64.4%). Intermediate risk recipients developing CMV after transplantation exhibited lower leukocyte, monocyte, and granulocyte counts and higher FoxP3+CD25+ frequencies in CD3+CD8+ T cells pre-transplantation compared to patients staying CMV negative. Pretransplant FoxP3+CD25+ in CD3+CD8+ T cells had the best discriminatory potential for CMV infection prediction within the first year after transplantation (AUC: 0.746). The FoxP3+CD25+ CD3+CD8+ T cell subset may aid in selecting intermediate risk kidney transplant recipients for CMV prophylaxis. [ABSTRACT FROM AUTHOR]

Published
2024

31. Vaccination acceptance and its associated factors in patients on hemodialysis in Austria: A nationwide survey

Author

Kolland, Michael, primary, Schreiber, Nikolaus, additional, Borenich, Andrea, additional, Hafner-Gießauf, Hildegard, additional, Waller, Ingmar, additional, Winkler, Hanns-Manfred, additional, Zitt, Emanuel, additional, Zollner-Schwetz, Ines, additional, König, Elisabeth, additional, Wagner-Skacel, Jolana, additional, Horn, Sabine, additional, Rosenkranz, Alexander R., additional, and Kirsch, Alexander H., additional

Published
2023
Full Text
View/download PDF

32. Rescue Allocation Modes in Eurotransplant Kidney Transplantation: Recipient Oriented Extended Allocation Versus Competitive Rescue Allocation—A Retrospective Multicenter Outcome Analysis

Author

Assfalg, Volker, primary, Miller, Gregor, additional, Stocker, Felix, additional, Hüser, Norbert, additional, Hartmann, Daniel, additional, Heemann, Uwe, additional, Tieken, Ineke, additional, Zanen, Wouter, additional, Vogelaar, Serge, additional, Rosenkranz, Alexander R., additional, Schneeberger, Stefan, additional, Függer, Reinhold, additional, Berlakovich, Gabriela, additional, Ysebaert, Dirk R., additional, Jacobs-Tulleneers-Thevissen, Daniel, additional, Mikhalski, Dimitri, additional, van Laecke, Steven, additional, Kuypers, Dirk, additional, Mühlfeld, Anja S., additional, Viebahn, Richard, additional, Pratschke, Johann, additional, Melchior, Sebastian, additional, Hauser, Ingeborg A., additional, Jänigen, Bernd, additional, Weimer, Rolf, additional, Richter, Nicolas, additional, Foller, Susan, additional, Schulte, Kevin, additional, Kurschat, Christine, additional, Harth, Ana, additional, Moench, Christian, additional, Rademacher, Sebastian, additional, Nitschke, Martin, additional, Krämer, Bernhard K., additional, Renders, Lutz, additional, Koliogiannis, Dionysios, additional, Pascher, Andreas, additional, Hoyer, Joachim, additional, Weinmann-Menke, Julia, additional, Schiffer, Mario, additional, Banas, Bernhard, additional, Hakenberg, Oliver, additional, Schwenger, Vedat, additional, Nadalin, Silvio, additional, Lopau, Kai, additional, Piros, Laszlo, additional, Nemes, Balazs, additional, Szakaly, Peter, additional, Bouts, Antonia, additional, Bemelman, Frederike J., additional, Sanders, Jan S., additional, de Vries, Aiko P. J., additional, Christiaans, Maarten H. L., additional, Hilbrands, Luuk, additional, van Zuilen, Arjan D., additional, Arnol, Miha, additional, Stippel, Dirk, additional, and Wahba, Roger, additional

Published
2023
Full Text
View/download PDF

33. Changes in cardiac troponins during hemodialysis depend on hemodialysis membrane and modality: a randomized crossover trial

Author

Kolland, Michael, primary, Amenitsch, Jascha, additional, Schreiber, Nikolaus, additional, Ginthör, Noemi, additional, Schuller, Max, additional, Riedl, Regina, additional, Rainer, Peter P, additional, Schneditz, Daniel, additional, Niedrist, Tobias, additional, Eller, Kathrin, additional, Krietemeyer, Benedikt, additional, Rosenkranz, Alexander R, additional, and Kirsch, Alexander H, additional

Published
2023
Full Text
View/download PDF

34. Challenges in the management of the kidney allograft: from decline to failure: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Author

Josephson, Michelle A., primary, Becker, Yolanda, additional, Budde, Klemens, additional, Kasiske, Bertram L., additional, Kiberd, Bryce A., additional, Loupy, Alexandre, additional, Małyszko, Jolanta, additional, Mannon, Roslyn B., additional, Tönshoff, Burkhard, additional, Cheung, Michael, additional, Jadoul, Michel, additional, Winkelmayer, Wolfgang C., additional, Zeier, Martin, additional, Ahn, Curie, additional, Alberú, Josefina, additional, Baliker, Mary, additional, Bamgboye, Ebun L., additional, Barber, Thelma, additional, Bensouda, Melissa, additional, Chadban, Steve J., additional, Dadhania, Darshana M., additional, Dębska-Ślizień, Alicja, additional, Devresse, Arnaud, additional, Ditzen, Beate, additional, Fowler, Kevin, additional, Gill, John S., additional, Jha, Vivekanand, additional, Khairallah, Pascale, additional, Knoll, Greg A., additional, Korst, Uwe, additional, Lee, Austin, additional, Legendre, Christophe, additional, Lentine, Krista L., additional, Lerma, Edgar V., additional, Lorenz, Elizabeth C., additional, Matas, Arthur J., additional, Mohan, Sumit, additional, Nazarewski, Sławomir, additional, Noronha, Irene L., additional, Obrador, Gregorio T., additional, Parekh, Rulan S., additional, Pavlakis, Martha, additional, Pascual, Julio, additional, Pilmore, Helen L., additional, Rosenkranz, Alexander R., additional, Rozen-Zvi, Benaya, additional, Roy-Chaudhury, Prabir, additional, Tanabe, Kazunari, additional, Wanner, Christoph, additional, Wasse, Haimanot, additional, and Yang, Chul-Woo, additional

Published
2023
Full Text
View/download PDF

35. The plethora of immunomodulatory drugs: opportunities for immune-mediated kidney diseases

Author

Odler, Balazs, primary, Tieu, Johanna, additional, Artinger, Katharina, additional, Chen-Xu, Michael, additional, Arnaud, Laurent, additional, Kitching, A Richard, additional, Terrier, Benjamin, additional, Thiel, Jens, additional, Cid, Maria C, additional, Rosenkranz, Alexander R, additional, Kronbichler, Andreas, additional, and Jayne, David R W, additional

Published
2023
Full Text
View/download PDF

39. Homocysteine contributes to atherogenic transformation of the aorta in rabbits in the absence of hypercholesterolemia

Author

Tehlivets, Oksana, primary, Almer, Gunter, additional, Brunner, Markus S., additional, Lechleitner, Margarete, additional, Sommer, Gerhard, additional, Kolb, Dagmar, additional, Leitinger, Gerd, additional, Diwoky, Clemens, additional, Wolinski, Heimo, additional, Habisch, Hansjörg, additional, Opriessnig, Peter, additional, Bogoni, Francesca, additional, Pernitsch, Dominique, additional, Kavertseva, Maria, additional, Bourgeois, Benjamin, additional, Kukilo, Jelena, additional, Tehlivets, Yuriy G., additional, Schwarz, Andreas N., additional, Züllig, Thomas, additional, Bubalo, Vladimir, additional, Schauer, Silvia, additional, Groselj-Strele, Andrea, additional, Hoefler, Gerald, additional, Rechberger, Gerald N., additional, Herrmann, Markus, additional, Eller, Kathrin, additional, Rosenkranz, Alexander R., additional, Madl, Tobias, additional, Frank, Sasa, additional, Holzapfel, Gerhard A., additional, Kratky, Dagmar, additional, Mangge, Harald, additional, and Hörl, Gerd, additional

Published
2023
Full Text
View/download PDF

40. Reduced COVID-19 morbidity and mortality in hemodialysis patients across the various Omicron sublineages—A retrospective analysis

Author

Schuller, Max, primary, Ginthör, Noemi Elisabeth, additional, Paller, Astrid, additional, Waller, Maximilian, additional, Köstenbauer, Martin, additional, Schreiber, Nikolaus Gustav Oskar, additional, Schabhüttl, Corinna, additional, Mischinger, Kathrin, additional, Hafner-Giessauf, Hildegard, additional, Rosenkranz, Alexander R., additional, Eller, Philipp, additional, and Eller, Kathrin, additional

Published
2023
Full Text
View/download PDF

41. Influence of Early Postoperative Basal Insulin Treatment and Post-Transplant Diabetes Mellitus Risk on Health-Related Quality of Life in Kidney Transplant Recipients—An Analysis of Data From a Randomized Controlled Trial

Author

Odler, Balazs, primary, Huemer, Matthias, additional, Schwaiger, Elisabeth, additional, Borenich, Andrea, additional, Kurnikowski, Amelie, additional, Krall, Marcell, additional, Hafner-Giessauf, Hildegard, additional, Eleftheriadis, Georgios, additional, Bachmann, Friderike, additional, Faura, Anna, additional, José Pérez-Sáez, María, additional, Pascual, Julio, additional, Budde, Klemens, additional, Rosenkranz, Alexander R., additional, Hecking, Manfred, additional, and Eller, Kathrin, additional

Published
2023
Full Text
View/download PDF

45. Estimation versus measurement of the glomerular filtration rate for kidney function assessment in patients with cancer undergoing cisplatin-based chemotherapy

Author

Klöckl, Marie-Christin, Kasparek, Anne-Katrin, Riedl, Jakob M., Moik, Florian, Mollnar, Stefanie, Stotz, Michael, Szkandera, Joanna, Terbuch, Angelika, Gerger, Armin, Niedrist, Tobias, Pichler, Martin, Bauernhofer, Thomas, Schilcher, Gernot, Zitta, Sabine, Rosenkranz, Alexander R., Friedl, Claudia, Stöger, Herbert, and Posch, Florian

Published
2020
Full Text
View/download PDF

46. Changes in cardiac troponins during hemodialysis depend on hemodialysis membrane and modality: a randomized crossover trial.

Author

Kolland, Michael, Amenitsch, Jascha, Schreiber, Nikolaus, Ginthör, Noemi, Schuller, Max, Riedl, Regina, Rainer, Peter P, Schneditz, Daniel, Niedrist, Tobias, Eller, Kathrin, Krietemeyer, Benedikt, Rosenkranz, Alexander R, and Kirsch, Alexander H

Subjects
CROSSOVER trials, CHEST pain, NON-ST elevated myocardial infarction, MYOCARDIAL infarction, BRAIN natriuretic factor, HEMODIALYSIS
Abstract

This article discusses the challenges of diagnosing acute coronary syndromes (ACS) in hemodialysis (HD) patients. The study aimed to explore the changes in cardiac troponin (cTn) levels during HD with different membranes and treatment modalities. The results showed significant differences in cTn changes depending on the type of membrane used. The data suggests that high-flux HD and MCO may be more effective in reducing troponin levels compared to low-flux HD and HDF. However, further research is needed to confirm these findings and establish a diagnostic algorithm for AMI in HD patients. [Extracted from the article]

Published
2024
Full Text
View/download PDF

47. Intact FGF23 predicts serum phosphate improvement after combined nicotinamide and phosphate binder treatment in hemodialysis patients

Author

Egli-Spichtig, Daniela, Hamid, Ahmad Kamal, Arroyo, Eva Maria Pastor, Ketteler, Markus, Wiecek, Andrzej, Rosenkranz, Alexander R, Pasch, Andreas, Lorenz, Horst, Hellmann, Burkhard, Karus, Michael, Ammer, Richard, Rubio-Aliaga, Isabel; https://orcid.org/0000-0003-1051-9511, Wagner, Carsten A; https://orcid.org/0000-0002-9874-8898, Egli-Spichtig, Daniela, Hamid, Ahmad Kamal, Arroyo, Eva Maria Pastor, Ketteler, Markus, Wiecek, Andrzej, Rosenkranz, Alexander R, Pasch, Andreas, Lorenz, Horst, Hellmann, Burkhard, Karus, Michael, Ammer, Richard, Rubio-Aliaga, Isabel; https://orcid.org/0000-0003-1051-9511, and Wagner, Carsten A; https://orcid.org/0000-0002-9874-8898

Abstract

Background: Hyperphosphatemia is associated with increased mortality and cardiovascular morbidity of end-stage kidney failure (ESKF) patients. Managing serum phosphate in ESKF patients is challenging and mostly based on limiting intestinal phosphate absorption with low phosphate diets and phosphate binders (PB). In a multi-centric, double-blinded, placebo-controlled study cohort of maintenance hemodialysis patients with hyperphosphatemia, we demonstrated the efficacy of nicotinamide modified release (NAMR) formulation treatment in addition to standard PB therapy in decreasing serum phosphate. Here we aimed to assess the relationship between phosphate, FGF23, inflammation and iron metabolism in this cohort. Methods: We measured the plasma concentrations of intact fibroblast growth factor 23 (iFGF23) and selected proinflammatory cytokines at baseline and Week 12 after initiating treatment. Results: We observed a strong correlation between iFGF23 and cFGF23 (C-terminal fragment plus iFGF23). We identified iFGF23 as a better predictor of changes in serum phosphate induced by NAMR and PB treatment compared with cFGF23. Recursive partitioning revealed at baseline and Week 12, that iFGF23 and cFGF23 together with T50 propensity were the most important predictors of serum phosphate, whereas intact parathyroid hormone (iPTH) played a minor role in this model. Furthermore, we found serum phosphate and iPTH as the best predictors of iFGF23 and cFGF23. Sex, age, body mass index, and markers of inflammation and iron metabolism had only a minor impact in predicting FGF23. Conclusion: Lowering serum phosphate in ESKF patients may depend highly on iFGF23 which is correlated to cFGF23 levels. Serum phosphate was the most important predictor of plasma FGF23 in this ESKF cohort.

Published
2023

49. Kidney Transplantation after Rescue Allocation - The Eurotransplant Experience

Author

Assfalg, Volker, Miller, Gregor, Stocker, Felix, van Meel, Marieke, Groenevelt, Tiny, Tieken, Ineke, Ankerst, Donna, Renders, Lutz, Novotny, Alexander, Hartmann, Daniel, Jell, Alissa, Rahmel, Axel, Wahba, Roger, Mühlfeld, Anja, Bouts, Antonia, Ysebaert, Dirk, Globke, Brigitta, Jacobs-Tulleneers-Thevissen, Daniel, Piros, László, Stippel, Dirk, Heller, Katharina, Eisenberger, Ute, van Laecke, Steven, Weimer, Rolf, Rosenkranz, Alexander R., Berger, Stefan, Fischer, Lutz, Kliem, Volker, Vondran, Florian, Sester, Urban, Schneeberger, Stefan, Harth, Ana, Kuypers, Dirk, Függer, Reinhold, Arnol, Miha, Christiaans, Maarten, Weinmann-Menke, Julia, Krüger, Bernd, Hilbrands, Luuk, Banas, Bernhard, Hakenberg, Oliver, Minnee, Robert, Schwenger, Vedat, Heyne, Nils, van Zuilen, Arjan, Reindl-Schwaighofer, Roman, Lopau, Kai, Hüser, Norbert, Heemann, Uwe, Huüser, Norbert, Surgery, Groningen Kidney Center (GKC), Groningen Institute for Organ Transplantation (GIOT), Paediatric Nephrology, ARD - Amsterdam Reproduction and Development, Interne Geneeskunde, MUMC+: MA Nefrologie (9), RS: NUTRIM - R3 - Respiratory & Age-related Health, Pediatrics, Basic (bio-) Medical Sciences, and Diabetes Pathology & Therapy

Subjects
Waiting time, kidney, PREDICTOR, medicine.medical_specialty, Tissue and Organ Procurement, Eurotransplant, medicine.medical_treatment, Medizin, Outcome analysis, deceased donor renal transplantation, COLD ISCHEMIA TIME, surgery, All institutes and research themes of the Radboud University Medical Center, Internal medicine, DIALYSIS, Medicine and Health Sciences, Humans, Medicine, standard allocation, FRAILTY, Kidney transplantation, Dialysis, Retrospective Studies, RISK, GRAFT FAILURE, Transplantation, Deceased donor, rescue allocation, business.industry, MORTALITY, Incidence (epidemiology), Graft Survival, algorithms Eurotransplant kidney allocation system, ASSOCIATION, medicine.disease, Kidney Transplantation, Tissue Donors, Confidence interval, Eurotransplant senior program, RECIPIENTS, Treatment Outcome, SURVIVAL, Human medicine, Renal disorders Radboud Institute for Health Sciences [Radboudumc 11], business
Abstract

BACKGROUND: At Eurotransplant (ET), kidneys are transferred to "rescue allocation" (RA), whenever the standard allocation (SA) algorithms Eurotransplant Kidney Allocation System (ETKAS) and Eurotransplant Senior Program (ESP) fail. We analyzed the outcome of RA. METHODS: Retrospective patient clinical and demographic characteristics association analyses were performed with graft outcomes for 2422 recipients of a deceased donor renal transplantation (DDRT) after RA versus 25 481 after SA from 71 centers across all ET countries from 2006 to 2018. RESULTS: Numbers of DDRTs after RA increased over the time, especially in Germany. RA played a minor role in ESP versus ETKAS (2.7% versus 10.4%). RA recipients and donors were older compared with SA recipients and donors, cold ischemia times were longer, waiting times were shorter, and the incidence of primary nonfunction was comparable. Among ETKAS recipients, HLA matching was more favorable in SA (mean 3.7 versus 2.5). In multivariate modeling, the incidence of graft loss in ETKAS recipients was reduced in RA compared with SA (subdistribution hazard ratio, 0.80; 95% confidence interval [0.70-0.91], P

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results