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6. Ischemic Colitis Related to Cocaine Abuse.

Author

Brown, David N., Rosenholtz, Mitchell J., and Marshall, John B.

Subjects
COCAINE abuse, MYOCARDIAL infarction, ISCHEMIC colitis, PEOPLE with diabetes, ISCHEMIA
Abstract

It is well recognized that cocaine use can be associated with serious cardiovascular complications, including myocardial infarction. Several case reports have recently linked the use of cocaine with ischemic events of the small bowel and colon. We report a case of ischemic colitis complicated by perforation in a 47-yr-old diabetic man which occurred after recreational cocaine use. The older age of the patient and underlying diabetes mellitus were unique aspects of our case, compared with others reported in the literature. The patient's history of cocaine use was not initially identified. After we obtained a negative arteriogram result, we went hack to the patient and the information was revealed. The literature regarding intestinal ischemia related to cocaine and other drugs/medications is reviewed. The abuse of cocaine should he considered in the differential diagnosis of acute intestinal vascular insufficiency syndromes. [ABSTRACT FROM AUTHOR]

Published
1994

7. PATHOLOGIC OBSERVATIONS IN ANIMALS AFTER SINGLE, BRIEF EXPOSURES TO HYDROGEN FLUORIDE

Author

CHEMICAL RESEARCH AND DEVELOPMENT LABS EDGEWOOD ARSENAL MD, ROSENHOLTZ, MITCHELL J., FORD, DUANE F., CHEMICAL RESEARCH AND DEVELOPMENT LABS EDGEWOOD ARSENAL MD, ROSENHOLTZ, MITCHELL J., and FORD, DUANE F.

Abstract

The objective of this work was to assess the influence of varying dosages of hydrogen fluoride (HF) inhaled on the qualitative and quantitative characteristics of the lesions produced, and to attempt to characterize the pathogenetic mechanisms involved. A gross and microscopic study was made of the major viscera of 32 rats exposed to lethal dosages 42 exposed to nonlethal dosages, and 18 non-exposed controls. The lung tissues from 4 rabbits, 2 exposed to nonlethal ranges and 2 not exposed, were also examined. Distinctive hepatic and renal lesions that may have diagnostic, therapeutic, and experimental pathologic significance were studied, following exposure of rats to lethal dosages of HF vapor. Severe local effects of contact were also observed. Brief, single exposures of rats to HF vapor produced both local and systemic pathologic effects. The systemic effects apparently represented a form of fluoride ion poisoning. The systemic lesions produced were (1) renal tubular necrosis and (2) distinctive hepatocellular globular change. The renal tubular lesions were confined to those portions of the proximal convoluted tubules in the inner cortex of the rat kidney. The demonstrated local effects included necrosis with accompanying acute inflammation of the skin and of the anterior aspects of the nasal passageways. (Author)

Published
1962

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