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Your search keyword '"Rosenblatt, Karin A"' showing total 142 results
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142 results on '"Rosenblatt, Karin A"'

4. The Relationship between Diet and Breast Cancer in Men (United States)

Author

Rosenblatt, Karin A., Thomas, David B., Jimenez, L. Margarita, Fish, Brian, McTiernan, Anne, Stalsberg, Helge, Stemhagen, Annette, Thompson, W. Douglas, Satariano, William, Austin, Donald F., Greenberg, Raymond S., Key, Charles, Kolonel, Laurence N., and West, Dee W.

Published
1999

15. Ionizing Radiation and Breast Cancer in Men (United States)

Author

Thomas, David B., Rosenblatt, Karin, Jimenez, L. Margarita, McTiernan, Anne, Stalsberg, Helge, Stemhagen, Annette, Thompson, W. Douglas, Satariano, William, Austin, Donald F., Greenberg, Raymond S., Key, Charles, Kolonel, Laurence N., and West, Dee W.

Published
1994

19. Dissolution testing of modified release products with biorelevant media: An OrBiTo ring study using the USP apparatus III and IV

Author

Reppas, Christos, primary, Vrettos, Napoleon-Nikolaos, additional, Dressman, Jennifer, additional, Andreas, Cord J., additional, Miyaji, Yoshihiro, additional, Brown, Jonathan, additional, Etherson, Kelly, additional, Hanley, Sarah, additional, Karkossa, Frank, additional, Karlsson, Eva, additional, Klein, Sandra, additional, Maier, Gerd-Michael, additional, McAllister, Mark, additional, Mistry, Nena, additional, Rosenblatt, Karin, additional, Schäfer, Kerstin Julia, additional, Smith, Kieran Lewis, additional, Tomaszewska, Irena, additional, Williams, James, additional, Winge, Fredrik, additional, and Vertzoni, Maria, additional

Published
2020
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23. Biorelevant dissolution testing of a weak base: Interlaboratory reproducibility and investigation of parameters controlling in vitro precipitation

Author

Berben, Philippe, primary, Ashworth, Lee, additional, Beato, Stefania, additional, Bevernage, Jan, additional, Bruel, Jean-Luc, additional, Butler, James, additional, Dressman, Jennifer, additional, Schäfer, Kerstin, additional, Hutchins, Paul, additional, Klumpp, Lukas, additional, Mann, James, additional, Nicolai, Janine, additional, Ojala, Krista, additional, Patel, Sanjaykumar, additional, Powell, Sarah, additional, Rosenblatt, Karin, additional, Tomaszewska, Irena, additional, Williams, James, additional, and Augustijns, Patrick, additional

Published
2019
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26. Validation of Dissolution Testing with Biorelevant Media: An OrBiTo Study

Author

Mann, James, primary, Dressman, Jennifer, additional, Rosenblatt, Karin, additional, Ashworth, Lee, additional, Muenster, Uwe, additional, Frank, Kerstin, additional, Hutchins, Paul, additional, Williams, James, additional, Klumpp, Lukas, additional, Wielockx, Kristina, additional, Berben, Philippe, additional, Augustijns, Patrick, additional, Holm, Rene, additional, Hofmann, Michael, additional, Patel, Sanjaykumar, additional, Beato, Stefania, additional, Ojala, Krista, additional, Tomaszewska, Irena, additional, Bruel, Jean-Luc, additional, and Butler, James, additional

Published
2017
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28. Fundamentos, Experiencias e Investigacion

Author

Reyes, Pamela H., Gloger, Daniela B., Torres, Eduardo N., and Rosenblatt, Karin G.

Abstract

Los días 20, 21 y 22 de agosto de 2009, se realizó el II Congreso Latinoamericano de Arte Terapia y III del Mercosur en Santiago de Chile. Fundación Telefónica., Art Therapy Online, Vol 1 No 1 (2010)

Published
2015
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29. Foundations, Experiences and Research

Author

Reyes, Pamela H., Gloger, Daniela B., Torres, Eduardo N., and Rosenblatt, Karin G.

Abstract

The II Latin American Congress on Art Therapy and III of Mercosur in Santiago, Chile was held on the 20, 21 and 22 August 2009 and was supported by the Foundation Telefónica., Art Therapy Online, Vol 1 No 1 (2010)

Published
2015
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30. The amorphous solid dispersion of the poorly soluble ABT-102 forms nano/microparticulate structures in aqueous medium: impact on solubility

Author

Frank,Kerstin J, Westedt,Ulrich, Rosenblatt,Karin M, Hölig,Peter, Rosenberg,Jörg, Mägerlein,Markus, Fricker,Gert, Brandl,Martin, Frank,Kerstin J, Westedt,Ulrich, Rosenblatt,Karin M, Hölig,Peter, Rosenberg,Jörg, Mägerlein,Markus, Fricker,Gert, and Brandl,Martin

Abstract

Kerstin J Frank,1,3 Ulrich Westedt,2 Karin M Rosenblatt,2 Peter Hölig,2 Jörg Rosenberg,2 Markus Mägerlein,2 Gert Fricker,3 Martin Brandl11Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Odense, Denmark; 2Abbott GmbH and Co. KG, Ludwigshafen, Germany; 3Department of Pharmaceutical Technology, University of Heidelberg, Heidelberg, GermanyAbstract: Amorphous solid dispersions (ASDs) are a promising formulation approach for poorly soluble active pharmaceutical ingredients (APIs), because they ideally enhance both dissolution rate and solubility. However, the mechanism behind this is not understood in detail. In the present study, we investigated the supramolecular and the nano/microparticulate structures that emerge spontaneously upon dispersion of an ASD in aqueous medium and elucidated their influence on solubility. The ASD, prepared by hot melt extrusion, contained the poorly soluble ABT-102 (solubility in buffer, 0.05 µg/mL), a hydrophilic polymer, and three surfactants. The apparent solubility of ABT-102 from the ASD-formulation was enhanced up to 200 times in comparison to crystalline ABT-102. At the same time, the molecular solubility, as assessed by inverse equilibrium dialysis, was enhanced two times. Asymmetrical flow field-flow fractionation in combination with a multiangle light-scattering detector, an ultraviolet detector, and a refractometer enabled us to separate and identify the various supramolecular assemblies that were present in the aqueous dispersions of the API-free ASD (placebo) and of binary/ternary blends of the ingredients. Thus, the supramolecular assemblies with a molar mass between 20,000 and 90,000 could be assigned to the polyvinylpyrrolidone/vinyl acetate 64, while two other kinds of assemblies were assigned to different surfactant assemblies (micelles). The amount of ABT-102 remaining associated with each of the assemblies upon fractionation was quantified offline with h

Published
2012

43. Breast Cancer In Men: Risk Factors with Hormonal Implications

Author

Thomas, David B., primary, Margarita Jimenez, L., additional, McTieman, Anne, additional, Rosenblatt, Karin, additional, Stalsberg, Helge, additional, Stemhagen, Annette, additional, Douglas Thompson, W., additional, McCrea Curnen, Mary G., additional, Satariano, William, additional, Austin, Donald F., additional, Greenberg, Raymond S., additional, Key, Charles, additional, Kolonel, Laurence N., additional, and West, Dee W., additional

Published
1992
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46. Occupational Exposure to Electromagnetic Fields and Breast Cancer in Men

Author

Demers, Paul A., primary, Thomas, David B., additional, Rosenblatt, Karin A., additional, Jimenez, L. Margarita, additional, McTiernan, Anne, additional, Stalsberg, Helge, additional, Stemhagen, Annette, additional, Thompson, W. Douglas, additional, Curnen, Mary G. McCrea, additional, Satariano, William, additional, Austin, Donald F., additional, Isacson, Peter, additional, Greenberg, Raymond S., additional, Key, Charles, additional, Kolonel, Laurence N., additional, and West, Dee W., additional

Published
1991
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48. Breast Cancer in Men: Aspects of Familial Aggregation.

Author

Rosenblatt, Karin A., Thomas, David B., McTiernan, Anne, Austin, Melissa A., Stalsberg, Helge, Stemhagen, Annette, Thompson, W. Douglas, Curnen, Mary G. McCrea, Satariano, William, Austin, Donald F., Isacson, Peter, Greenberg, Raymond S., Key, Charles, Kolonel, Laurence, and West, Dee

Abstract

Familial aggregation of breast cancer in males was investigated in a population-based case-control study. Cases were ascertained from 10 Surveillance, Epidemiology, and End Results Program registries in the United States between 1983 and 1986. Controls were identified by random-digit dialing and from lists of Medicare recipients. The relative odds of developing breast cancer were similar in men with affected paternal and maternal relatives and in men with affected mothers and sisters. The risk increased with the number of affected relatives. The relative odds of developing breast cancer were greater in men with first-degree relatives who developed their mammary neoplasm before the age of 45 than in men with older first-degree affected relatives; the enhancement of risk in men with an affected sister was greater in those under age 60 than in older men. These results are similar to those observed by others in studies of breast cancer in women. [J Natl Cancer Inst 83:849–854, 1991] [ABSTRACT FROM PUBLISHER]

Published
1991

49. Depot-medroxyprogesterone acetate (dmpa) and risk of edometrial cancer.

Author

Silpisornkosol, Suporn, Pardthaisong, Tieng, Sahapong, Virote, Theetranont, Choti, Boosiri, Banpot, Chutivongse, Supawat, Virutamasen, Pramuan, Wongsrchanalai, Chansuda, Sindhvananda, Sermsri, Koetsawang, Suporn, Rachawat, Daungdao, Koetsawang, Amom, Langley, F. A., Thomas Study Coordinator, David B., Ray, Roberta M., Noonan, Elizabeth A., Stanford, Janet L., Rosenblatt, Karin A., Holck, Susan, and Farley, Timothy M. M.

Published
1991
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50. Poly(vinyl alcohol) as Emulsifier Stabilizes Solid Triglyceride Drug Carrier Nanoparticles in the α-Modification

Author

Rosenblatt, Karin M. and Bunjes, Heike

Abstract

Colloidal dispersions of solid lipids are under intensive investigation as drug delivery systems. In the present study, poly(vinyl alcohol) (PVA) was tested as an alternative stabilizer for triglyceride nanoparticles. The dispersions contained 10% triglyceride (trimyristin or tristearin) and 5% PVA and were prepared by high pressure melt homogenization. The nanoparticle dispersions were investigated for their thermal behavior and storage stability with special regard to the polymorphic transitions of the triglyceride matrix, including effects of storage temperature and the incorporation of model drugs (diazepam, ubidecarenone) using photon correlation spectroscopy, differential scanning calorimetry, X-ray diffraction, and transmission electron microscopy. The release of the model drug diazepam from a selected nanoparticle dispersion was investigated with differential pulse polarography. Triglyceride nanoparticles prepared with PVA displayed an unusually high stability of the metastable α-modification depending on the type of triglyceride and the storage conditions. In tristearin nanoparticles, the α-polymorph was stable for at least 9 months at refrigerator temperature and the particles exhibited a spherical shape in electron microscopic investigations. Moreover, the α-form in PVA-stabilized tristearin nanoparticles seemed to be highly disordered, as it did not lead to a pronounced small-angle X-ray reflection. Storage at higher temperatures led to a transformation of the particles into the β-modification, which usually was accompanied by an increase in particle size. Incorporation of the two model drugs did not change the crystal modification of the particle matrix to a large extent. After dilution into a large volume of release medium, a large fraction of the model drug diazepam was released immediately but there was no further release over several hours. The high stability of PVA-stabilized tristearin nanoparticles with regard to particle size and α-modification makes them suitable as a model for investigations on the influence of the polymorphic form (e.g., in comparison with nanoparticles in the more stable β-modification) on pharmaceutically important parameters such as drug load and drug release.

Published
2009
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