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2. Automated Quantitative Image-Derived Input Function for the Estimation of Cerebral Blood Flow Using Oxygen-15-Labelled Water on a Long-Axial Field-of-View PET/CT Scanner.

Author

Andersen, Thomas Lund, Andersen, Flemming Littrup, Haddock, Bryan, Rosenbaum, Sverre, Larsson, Henrik Bo Wiberg, Law, Ian, and Lindberg, Ulrich

Subjects
POSITRON emission tomography, CEREBRAL circulation, ARTIFICIAL intelligence, BRAIN mapping, SCANNING systems
Abstract

The accurate estimation of the tracer arterial blood concentration is crucial for reliable quantitative kinetic analysis in PET. In the current work, we demonstrate the automatic extraction of an image-derived input function (IDIF) from a CT AI-based aorta segmentation subsequently resliced to a dynamic PET series acquired on a Siemens Vision Quadra long-axial field of view scanner in 10 human subjects scanned with [15O]H2O. We demonstrate that the extracted IDIF is quantitative and in excellent agreement with a delay- and dispersion-corrected sampled arterial input function (AIF). Perfusion maps in the brain are calculated and compared from the IDIF and AIF, respectively, showed a high degree of correlation. The results demonstrate the possibility of defining a quantitatively correct IDIF compared with AIFs from the new-generation high-sensitivity and high-time-resolution long-axial field-of-view PET/CT scanners. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Antithrombotic Treatment for Cervical Artery Dissection: A Systematic Review and Individual Patient Data Meta-Analysis.

Author

Kaufmann, Josefin E., Harshfield, Eric L., Gensicke, Henrik, Wegener, Susanne, Michel, Patrik, Kägi, Georg, Nedeltchev, Krassen, Kellert, Lars, Rosenbaum, Sverre, Nolte, Christian H., Christensen, Hanne, Arnold, Marcel, Lyrer, Philippe, Levi, Christopher, Bath, Philip M., Engelter, Stefan T., Traenka, Christopher, and Markus, Hugh S.

Published
2024
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5. Aspirin versus anticoagulation in cervical artery dissection (TREAT-CAD): an open-label, randomised, non-inferiority trial

Author

Kahles, Timo, Nedeltchev, Krassen, Altersberger, Valerian, Bonati, Leo H, Brehm, Alex, Bruni, Nicole, De Marchis, Gian Marco, Engelter, Stefan T, Fabbro, Thomas, Fisch, Urs, Fladt, Joachim, Gensicke, Henrik, Hert, Lisa, Lyrer, Philippe A, Maurer, Marina, Peters, Nils, Polymeris, Alexandros, Psychogios, Marios-Nikos, Schaedelin, Sabine, Stippich, Christoph, Thilemann, Sebastian, Traenka, Christopher, Wagner, Benjamin, Arnold, Marcel, Fischer, Urs, Goeggel Simonetti, Barbara, Gralla, Jan, Heldner, Mirjam, Jung, Simon, Leib, Stephen L, Seiffge, David J, Mueller, Hubertus, Sveikata, Lukas, Sztajzel, Roman, Correia, Pamela, Eskandari, Ashraf, Meyer, Ivo, Michel, Patrik, Nannoni, Stefania, Remillard, Suzette, Sirimarco, Gaia, Zachariadis, Alexandros, Kaegi, Georg, Mueller, Anna, Vehoff, Jochen, Hamann, Janne, Luft, Andreas R, Steiner, Levke, Wegener, Susanne, Erdur, Hebun J, Nolte, Christian H, von Rennenberg, Regina, Scheitz, Jan F, Feil, Katharina, Kellert, Lars, Christensen, Hanne, Rosenbaum, Sverre, Schaedelin, Sabine A, Simonetti, Barbara Goeggel, Kägi, Georg, Seiffge, David, Polymeris, Alexandros A, and Lyrer, Philippe

Published
2021
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6. Toward Individual Treatment in Cervical Artery Dissection: Subgroup Analysis of the TREAT‐CAD Randomized Trial.

Author

Kaufmann, Josefin E., Gensicke, Henrik, Schaedelin, Sabine, Luft, Andreas R., Goeggel‐Simonetti, Barbara, Fischer, Urs, Michel, Patrik, Strambo, Davide, Kägi, Georg, Vehoff, Jochen, Nedeltchev, Krassen, Kahles, Timo, Kellert, Lars, Rosenbaum, Sverre, von Rennenberg, Regina, Riegler, Christoph, Seiffge, David, Sarikaya, Hakan, Zietz, Annaelle, and Wischmann, Johannes

Subjects
MAGNETIC resonance imaging, RANDOMIZED controlled trials, SUBGROUP analysis (Experimental design), CEREBRAL ischemia, TREATMENT delay (Medicine)
Abstract

Objective: Uncertainty remains regarding antithrombotic treatment in cervical artery dissection. This analysis aimed to explore whether certain patient profiles influence the effects of different types of antithrombotic treatment. Methods: This was a post hoc exploratory analysis based on the per‐protocol dataset from TREAT‐CAD (NCT02046460), a randomized controlled trial comparing aspirin to anticoagulation in patients with cervical artery dissection. We explored the potential effects of distinct patient profiles on outcomes in participants treated with either aspirin or anticoagulation. Profiles included (1) presenting with ischemia (no/yes), (2) occlusion of the dissected artery (no/yes), (3) early versus delayed treatment start (median), and (4) intracranial extension of the dissection (no/yes). Outcomes included clinical (stroke, major hemorrhage, death) and magnetic resonance imaging outcomes (new ischemic or hemorrhagic brain lesions) and were assessed for each subgroup in separate logistic models without adjustment for multiple testing. Results: All 173 (100%) per‐protocol participants were eligible for the analyses. Participants without occlusion had decreased odds of events when treated with anticoagulation (odds ratio [OR] = 0.28, 95% confidence interval [CI] = 0.07–0.86). This effect was more pronounced in participants presenting with cerebral ischemia (n = 118; OR = 0.16, 95% CI = 0.04–0.55). In the latter, those with early treatment (OR = 0.26, 95% CI = 0.07–0.85) or without intracranial extension of the dissection (OR = 0.34, 95% CI = 0.11–0.97) had decreased odds of events when treated with anticoagulation. Interpretation: Anticoagulation might be preferable in patients with cervical artery dissection presenting with ischemia and no occlusion or no intracranial extension of the dissection. These findings need confirmation. ANN NEUROL 2024;95:886–897 [ABSTRACT FROM AUTHOR]

Published
2024
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7. Long-term stroke risk in Moyamoya disease.

Author

Birkeland, Peter, Hansen, Victoria, Tharmabalan, Vinosha, Lauritsen, Jens, Nielsen, Troels, Truelsen, Thomas, Rosenbaum, Sverre, and von Weitzel-Mudersbach, Paul

Subjects
MOYAMOYA disease, STROKE, INTRACRANIAL hemorrhage, DISEASE risk factors, ISCHEMIC stroke
Abstract

Background: Moyamoya disease (MMD) is considered a progressive disease with an ongoing risk of recurrent stroke. However, there is a lack of long-term observational data to quantify the extent of the stroke risk. Methods: This study aimed to provide insight into the long-term stroke risk in MMD and explore possible risk factors for stroke. Records from all patients diagnosed with MMD in 13 clinical departments from 6 different Danish hospitals between 1994 and 2017 were retrospectively reviewed until 2021. Results: The cohort comprised 50 patients (33 females and 17 males). Patients were followed up for a median of 9.4 years, with more than 10 years of follow-up for 24 patients. Ten patients had 11 new stroke events—6 ischemic strokes and 5 brain hemorrhages. Events occurred at a median of 7 years and up to 25 years after diagnosis. The overall Kaplan-Meier 5-year stroke risk was 10%. Patients with bypass performed had significantly fewer events than conservatively treated patients (HR 0.25, 95% confidence interval (CI) 0.07–0.91, p < 0.05). All but one event occurred in females, a difference that reached statistical significance. Conclusions: The study provides data on the extent of the risk of recurrent stroke in MMD. Bypass surgery patients had fewer stroke events than those treated conservatively. There was a trend toward a higher stroke risk in females. Data access statement: The data supporting this study's findings are available from the corresponding author upon reasonable request. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Long-term stroke risk in moyamoya disease

Author

Birkeland, Peter, primary, Hansen, Victoria, additional, Tharmabalan, Vinosha, additional, Lauritsen, Jens, additional, Nielsen, Troels Halfeld, additional, Truelsen, Thomas Clement, additional, Rosenbaum, Sverre, additional, and von Weitzel- Mudersbach, Paul, additional

Published
2023
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9. Corrigendum: Sex-differences in oral anticoagulant-related intracerebral hemorrhage

Author

Grundtvig, Josefine, primary, Ovesen, Christian, additional, Steiner, Thorsten, additional, Carcel, Cheryl, additional, Gaist, David, additional, Christensen, Louisa, additional, Marstrand, Jacob, additional, Meden, Per, additional, Rosenbaum, Sverre, additional, Iversen, Helle K., additional, Kruuse, Christina, additional, Christensen, Thomas, additional, Ægidius, Karen, additional, Havsteen, Inger, additional, and Christensen, Hanne, additional

Published
2022
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11. Sex-Differences in Oral Anticoagulant-Related Intracerebral Hemorrhage

Author

Grundtvig, Josefine, primary, Ovesen, Christian, additional, Steiner, Thorsten, additional, Carcel, Cheryl, additional, Gaist, David, additional, Christensen, Louisa, additional, Marstrand, Jacob, additional, Meden, Per, additional, Rosenbaum, Sverre, additional, Iversen, Helle K., additional, Kruuse, Christina, additional, Christensen, Thomas, additional, Ægidius, Karen, additional, Havsteen, Inger, additional, and Christensen, Hanne, additional

Published
2022
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12. sj-pdf-1-eso-10.1177_23969873211008770 - Supplemental material for Trends in incidence of oral anticoagulant-related intracerebral hemorrhage and sales of oral anticoagulants in Capital Region of Denmark 2010–2017

Author

Grundtvig, Josefine, Ovesen, Christian, Havsteen, Inger, Christensen, Thomas, Gaist, David, Iversen, Helle K, Kruuse, Christina, Lilja-Cyron, Alexander, Ægidius, Karen, Rosenbaum, Sverre, Meden, Per, Marstrand, Jacob, Christensen, Louisa, Steiner, Thorsten, and Christensen, Hanne

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-1-eso-10.1177_23969873211008770 for Trends in incidence of oral anticoagulant-related intracerebral hemorrhage and sales of oral anticoagulants in Capital Region of Denmark 2010–2017 by Josefine Grundtvig, Christian Ovesen, Inger Havsteen, Thomas Christensen, David Gaist, Helle K Iversen, Christina Kruuse, Alexander Lilja-Cyron, Karen Ægidius, Sverre Rosenbaum, Per Meden, Jacob Marstrand, Louisa Christensen, Thorsten Steiner and Hanne Christensen: ; for the PHYS-Stroke study group in European Stroke Journal

Published
2021
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13. Aspirin versus anticoagulation in cervical artery dissection (TREAT-CAD): an open-label, randomised, non-inferiority trial

Author

Engelter, Stefan T, Traenka, Christopher, Gensicke, Henrik, Schaedelin, Sabine A, Luft, Andreas R, Goeggel Simonetti, Barbara, Fischer, Urs, Michel, Patrik, Sirimarco, Gaia, Kägi, Georg, Vehoff, Jochen, Nedeltchev, Krassen, Kahles, Timo, Kellert, Lars, Rosenbaum, Sverre, von Rennenberg, Regina, Sztajzel, Roman, Leib, Stephen L, Jung, Simon, Gralla, Jan, Bruni, Nicole, Seiffge, David, Feil, Katharina, Polymeris, Alexandros A, Steiner, Levke, Hamann, Janne, Bonati, Leo H, Brehm, Alex, De Marchis, Gian Marco, Peters, Nils, Stippich, Christoph, Nolte, Christian H, Christensen, Hanne, Wegener, Susanne, Psychogios, Marios-Nikos, Arnold, Marcel, and Lyrer, Philippe

Subjects
570 Life sciences, biology, 610 Medicine & health
Abstract

BACKGROUND Cervical artery dissection is a major cause of stroke in young people (aged

Published
2021
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14. Aspirin versus anticoagulation in cervical artery dissection (TREAT-CAD): an open-label, randomised, non-inferiority trial

Author

Engelter, Stefan T, primary, Traenka, Christopher, additional, Gensicke, Henrik, additional, Schaedelin, Sabine A, additional, Luft, Andreas R, additional, Simonetti, Barbara Goeggel, additional, Fischer, Urs, additional, Michel, Patrik, additional, Sirimarco, Gaia, additional, Kägi, Georg, additional, Vehoff, Jochen, additional, Nedeltchev, Krassen, additional, Kahles, Timo, additional, Kellert, Lars, additional, Rosenbaum, Sverre, additional, von Rennenberg, Regina, additional, Sztajzel, Roman, additional, Leib, Stephen L, additional, Jung, Simon, additional, Gralla, Jan, additional, Bruni, Nicole, additional, Seiffge, David, additional, Feil, Katharina, additional, Polymeris, Alexandros A, additional, Steiner, Levke, additional, Hamann, Janne, additional, Bonati, Leo H, additional, Brehm, Alex, additional, De Marchis, Gian Marco, additional, Peters, Nils, additional, Stippich, Christoph, additional, Nolte, Christian H, additional, Christensen, Hanne, additional, Wegener, Susanne, additional, Psychogios, Marios-Nikos, additional, Arnold, Marcel, additional, Lyrer, Philippe, additional, Altersberger, Valerian, additional, Engelter, Stefan T, additional, Fabbro, Thomas, additional, Fisch, Urs, additional, Fladt, Joachim, additional, Hert, Lisa, additional, Lyrer, Philippe A, additional, Maurer, Marina, additional, Polymeris, Alexandros, additional, Schaedelin, Sabine, additional, Thilemann, Sebastian, additional, Wagner, Benjamin, additional, Goeggel Simonetti, Barbara, additional, Heldner, Mirjam, additional, Seiffge, David J, additional, Mueller, Hubertus, additional, Sveikata, Lukas, additional, Correia, Pamela, additional, Eskandari, Ashraf, additional, Meyer, Ivo, additional, Nannoni, Stefania, additional, Remillard, Suzette, additional, Zachariadis, Alexandros, additional, Kaegi, Georg, additional, Mueller, Anna, additional, Erdur, Hebun J, additional, and Scheitz, Jan F, additional

Published
2021
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15. Trends in incidence of oral anticoagulant-related intracerebral hemorrhage and sales of oral anticoagulants in Capital Region of Denmark 2010–2017

Author

Grundtvig, Josefine, primary, Ovesen, Christian, additional, Havsteen, Inger, additional, Christensen, Thomas, additional, Gaist, David, additional, Iversen, Helle K, additional, Kruuse, Christina, additional, Lilja-Cyron, Alexander, additional, Ægidius, Karen, additional, Rosenbaum, Sverre, additional, Meden, Per, additional, Marstrand, Jacob, additional, Christensen, Louisa, additional, Steiner, Thorsten, additional, and Christensen, Hanne, additional

Published
2021
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18. Biomarkers and antithrombotic treatment in cervical artery dissection - Design of the TREAT-CAD randomised trial

Author

Traenka, Christopher, Gensicke, Henrik, Schaedelin, Sabine, Luft, Andreas, Arnold, Marcel, Michel, Patrik, Kägi, Georg, Kahles, Timo, Nolte, Christian H, Kellert, Lars, Rosenbaum, Sverre, Sztaizel, Roman, Brehm, Alex, Stippich, Christoph, Psychogios, Marios, Lyrer, Philippe, Engelter, Stefan T, University of Zurich, and Engelter, Stefan T

Subjects
2728 Neurology (clinical), 10043 Clinic for Neuroradiology, 610 Medicine & health, 2705 Cardiology and Cardiovascular Medicine, 10040 Clinic for Neurology
Abstract

Introduction The type of antithrombotic treatment in cervical artery dissection patients is still a matter of debate. Most physicians prefer anticoagulants over antiplatelet agents for stroke prevention. However, this approach is not evidence-based and antiplatelets might be as safe and as effective. The 'Biomarkers and Antithrombotic Treatment in Cervical Artery Dissection' ('TREAT-CAD') trial (clinicaltrials.gov: NCT02046460) compares Aspirin to oral anticoagulants (vitamin K antagonists) with regard to efficacy and safety by using both clinical and imaging surrogate outcome measures. TREAT-CAD tests the hypothesis, that aspirin is as safe and effective as vitamin K antagonists. Patients and methods TREAD-CAD is a Prospective, Randomised controlled, Open-labelled, multicentre, non-inferiority trial with Blinded assessment of outcome Events (PROBE-design). Key eligibility criteria are (i) clinical symptoms attributable to cervical artery dissection and (ii) verification of the cervical artery dissection diagnosis by established magnetic resonance imaging criteria. Patients are randomised to receive either Aspirin 300 mg daily or vitamin K antagonists for 90 days. Results Primary outcomes are assessed at 14 ± 10 days (magnetic resonance imaging and clinical examination) and at 90 ± 30 days (clinical examinations). The primary endpoint is a composite outcome measure - labelled Cerebrovascular Ischemia, major Hemorrhagic events or Death (CIHD) - and includes (i) occurrence of any stroke (including retinal infarction), (ii) new ischaemic lesions on diffusion-weighted magnetic resonance imaging, (iii) any major extracranial haemorrhage, (iv) any symptomatic intracranial haemorrhage, (v) any new haemorrhagic lesion visible on paramagnetic-susceptible sequences and (vi) death. Discussion After database closure, (i) central verification of cervical artery dissection diagnosis will be done by two experienced raters, (ii) adjudication of outcome events will be performed by independent adjudication committees, separately for clinical and imaging outcomes. The primary analysis will be done on the per protocol data set. The targeted sample size consists of 169 evaluable patients in the per protocol data set. Conclusion TREAT-CAD is testing the non-inferiority of Aspirin versus vitamin K antagonists treatment in patients with symptomatic cervical artery dissection by combined clinical and magnetic resonance imaging outcomes.

Published
2020
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19. Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data

Author

Thomalla, Götz, primary, Boutitie, Florent, additional, Ma, Henry, additional, Koga, Masatoshi, additional, Ringleb, Peter, additional, Schwamm, Lee H, additional, Wu, Ona, additional, Bendszus, Martin, additional, Bladin, Christopher F, additional, Campbell, Bruce C V, additional, Cheng, Bastian, additional, Churilov, Leonid, additional, Ebinger, Martin, additional, Endres, Matthias, additional, Fiebach, Jochen B, additional, Fukuda-Doi, Mayumi, additional, Inoue, Manabu, additional, Kleinig, Timothy J, additional, Latour, Lawrence L, additional, Lemmens, Robin, additional, Levi, Christopher R, additional, Leys, Didier, additional, Miwa, Kaori, additional, Molina, Carlos A, additional, Muir, Keith W, additional, Nighoghossian, Norbert, additional, Parsons, Mark W, additional, Pedraza, Salvador, additional, Schellinger, Peter D, additional, Schwab, Stefan, additional, Simonsen, Claus Z, additional, Song, Shlee S, additional, Thijs, Vincent, additional, Toni, Danilo, additional, Hsu, Chung Y, additional, Wahlgren, Nils, additional, Yamamoto, Haruko, additional, Yassi, Nawaf, additional, Yoshimura, Sohei, additional, Warach, Steven, additional, Hacke, Werner, additional, Toyoda, Kazunori, additional, Donnan, Geoffrey A, additional, Davis, Stephen M, additional, Gerloff, Christian, additional, Acosta, Boris Raul, additional, Aegidius, Karen, additional, Albiker, Christian, additional, Alegiani, Anna, additional, Almendrote, Miriam, additional, Alonso, Angelika, additional, Althaus, Katharina, additional, Amarenco, Pierre, additional, Amiri, Hemasse, additional, Anders, Bettina, additional, Aniculaesei, Adriana, additional, Appleton, Jason, additional, Arenillas, Juan, additional, Back, Christina, additional, Bähr, Christian, additional, Bardutzky, Jürgen, additional, Baronnet-Chauvet, Flore, additional, Bathe-Peters, Rouven, additional, Bayer-Karpinska, Anna, additional, Becerra, Juan L., additional, Beck, Christoph, additional, Belchí Guillamon, Olga, additional, Benoit, Amandine, additional, Berhoune, Nadia, additional, Bindila, Daniela, additional, Birchenall, Julia, additional, Blanc-Lasserre, Karine, additional, Blanco Gonzales, Miguel, additional, Bobinger, Tobias, additional, Bodechtel, Ulf, additional, Bodiguel, Eric, additional, Bojaryn, Urszula, additional, Bonnet, Louise, additional, Bouamra, Benjamin, additional, Bourgeois, Paul, additional, Breuer, Lorenz, additional, Breynaert, Ludovic, additional, Broughton, David, additional, Brouns, Raf, additional, Brugirard, Sébastian, additional, Bruneel, Bart, additional, Buggle, Florian, additional, Cakmak, Serkan, additional, Calleja, Ana, additional, Calvet, David, additional, Carrera, David, additional, Chen, Hsin-Chieh, additional, Cheripelli, Bharath, additional, Cho, Tae-Hee, additional, Choe, Chi-un, additional, Choy, Lillian, additional, Christensen, Hanne, additional, Ciatipis, Mareva, additional, Cloud, Geoffrey, additional, Cogez, Julien, additional, Cortijo, Elisa, additional, Crozier, Sophie, additional, Damgaard, Dorte, additional, Dani, Krishna, additional, De Coene, Beatrijs, additional, De Hollander, Isabel, additional, De Keyser, Jacques, additional, De Klippel, Nina, additional, De Maeseneire, Charlotte, additional, De Smedt, Ann, additional, del Mar Castellanos Rodrigo, Maria, additional, Deltour, Sandrine, additional, Demeestere, Jelle, additional, Derex, Laurent, additional, Desfontaines, Philippe, additional, Dittrich, Ralf, additional, Dixit, Anand, additional, Dobbels, Laurens, additional, Domigo, Valérie, additional, Dorado, Laura, additional, Druart, Charlotte, additional, Dupont, Kristina Hougaard, additional, Dusart, Anne, additional, Dziewas, Rainer, additional, Ebner, Matthias, additional, Edjali-Goujon, Myriam, additional, Eisele, Philipp, additional, El Tawil, Salwa, additional, Elhfnawy, Ahmed, additional, Etexberria, Ana, additional, Evans, Nicholas, additional, Fandler, Simon, additional, Fazekas, Franz, additional, Felix, Sandra, additional, Fiebach, Jochen B., additional, Fiehler, Jens, additional, Filipov, Alexandra, additional, Filipski, Katharina, additional, Fleischmann, Robert, additional, Foerch, Christian, additional, Ford, Ian, additional, Gaenslen, Alexandra, additional, Galinovic, Ivana, additional, Gancedo, Elena Meseguer, additional, Ganeshan, Ramanan, additional, García Esperón, Carlos, additional, Garrido, Alicia, additional, Gattringer, Thomas, additional, Geraghty, Olivia, additional, Geran, Rohat, additional, Gerner, Stefan, additional, Godon-Hardy, Sylvie, additional, Göhler, Jos, additional, Golsari, Amir, additional, Gomis, Meritxell, additional, Gorriz, David, additional, Gramse, Verena, additional, Grau, Laia, additional, Griebe, Martin, additional, Guerrero, Cristina, additional, Guerzoglu, Damla, additional, Guettier, Sophie, additional, Guiraud, Vincent, additional, Gumbinger, Christoph, additional, Gunreben, Ignaz, additional, Haertig, Florian, additional, Hametner, Christian, additional, Hanseeuw, Bernard, additional, Hansen, Andreas, additional, Hansen, Jakob, additional, Harbo, Thomas, additional, Harloff, Andreas, additional, Harmel, Peter, additional, Häusler, Karl Georg, additional, Heinen, Florian, additional, Held, Valentin, additional, Hellwig, Simon, additional, Hemelsoet, Dimitri, additional, Hennerici, Michael, additional, Herm, Juliane, additional, Hermans, Sylvia, additional, Hernández, María, additional, Hervas Vicente, Jose, additional, Hjort, Niels, additional, Hobeanu, Cristina, additional, Hobohm, Carsten, additional, Höfner, Elmar, additional, Hohenbichler, Katharina, additional, Hommel, Marc, additional, Hoppe, Julia, additional, Hornberger, Eva, additional, Hoyer, Carolin, additional, Huang, Xuya, additional, Ipsen, Nils, additional, Isern, Irina, additional, Ispierto, Lourdes, additional, Iversen, Helle, additional, Jeppesen, Lise, additional, Jimenez, Marta, additional, Jungehülsing, Jan, additional, Jüttler, Eric, additional, Kalladka, Dheeraj, additional, Kallmünzer, Bernd, additional, Kar, Arindam, additional, Kellert, Lars, additional, Kemmling, André, additional, Kessler, Tobias, additional, Khan, Usman, additional, Klein, Matthias, additional, Kleinschnitz, Christoph, additional, Klockziem, Matti, additional, Knops, Michael, additional, Koehler, Luzie, additional, Koehrmann, Martin, additional, Kohlfürst, Heinz, additional, Kollmar, Rainer, additional, Kraft, Peter, additional, Krause, Thomas, additional, Kristensen, Bo, additional, Kröber, Jan M., additional, Kurka, Natalia, additional, Ladoux, Alexandre, additional, Laloux, Patrice, additional, Lamy, Catherine, additional, Landrault, Emmanuelle, additional, Lauer, Arne, additional, Lebely, Claire, additional, Leempoel, Jonathan, additional, Lees, Kennedy, additional, Leger, Anne, additional, Legrand, Laurence, additional, Li, Lin, additional, Löbbe, Anna-Mareike, additional, London, Frederic, additional, Lopez-cancio, Elena, additional, Lorenz, Matthias, additional, Louw, Stephen, additional, Lovelock, Caroline, additional, Lozano Sánchez, Manuel, additional, Lucente, Giuseppe, additional, Lückl, Janos, additional, Luna, Alain, additional, Macha, Kosmas, additional, Machet, Alexandre, additional, Mackenrodt, Daniel, additional, Madzar, Dominik, additional, Majoie, Charles, additional, Männer, Anika, additional, Maqueda, Vicky, additional, Marstrand, Jacob, additional, Martinez, Alicia, additional, Marzina, Annika, additional, Mechthouff, Laura, additional, Meden, Per, additional, Meersman, Guy, additional, Meier, Julia, additional, Mellerio, Charles, additional, Menn, Oliver, additional, Meyer, Nadja, additional, Michalski, Dominik, additional, Michels, Peter, additional, Michelsen, Lene, additional, Millán Torne, Monica, additional, Minnerup, Jens, additional, Modrau, Boris, additional, Moeller, Sebastian, additional, Møller, Anette, additional, Morel, Nathalie, additional, Moreton, Fiona, additional, Morin, Ludovic, additional, Moulin, Thierry, additional, Moynihan, Barry, additional, Mueller, Anne K., additional, Muir, Keith W., additional, Mulero, Patricia, additional, Mundiyanapurath, Sibu, additional, Mutzenbach, Johannes, additional, Nagel, Simon, additional, Naggara, Oliver, additional, Nallasivan, Arumugam, additional, Navalpotro, Irene, additional, Nave, Alexander H., additional, Nederkoorn, Paul, additional, Neeb, Lars, additional, Neugebauer, Hermann, additional, Neumann-Haefelin, Tobias, additional, Oberndorfer, Stefan, additional, Opherk, Christian, additional, Oppel, Lorenz, additional, Oppenheim, Catherine, additional, Orthgieß, Johannes, additional, Ostergaard, Leif, additional, Paindeville, Perrine, additional, Palomeras, Ernest, additional, Panitz, Verena, additional, Patel, Bhavni, additional, Peeters, Andre, additional, Peeters, Dirk, additional, Pellisé, Anna, additional, Pelz, Johann, additional, Pereira, Anthony, additional, Pérez de la Ossa, Natalia, additional, Perry, Richard, additional, Petraza, Salvador, additional, Peysson, Stéphane, additional, Pfeilschifter, Waltraud, additional, Pichler, Alexander, additional, Pierskalla, Alexandra, additional, Pledl, Hans-Werner, additional, Poli, Sven, additional, Pomrehn, Katrin, additional, Poulsen, Marika, additional, Prats, Luis, additional, Presas, Silvia, additional, Prohaska, Elisabeth, additional, Puetz, Volker, additional, Puig, Josep, additional, Puig Alcántara, Josep, additional, Purrucker, Jan, additional, Quenardelle, Veronique, additional, Ramachandran, Sankaranarayanan, additional, Raphaelle, Soulliard, additional, Raposo, Nicolas, additional, Reiff, Tilman, additional, Remmers, Michel, additional, Renou, Pauline, additional, Ribitsch, Martin, additional, Richter, Hardy, additional, Ritter, Martin, additional, Ritzenthaler, Thomas, additional, Rodier, Gilles, additional, Rodriguez-Regent, Christine, additional, Rodríguez-Yáñez, Manuel, additional, Roennefarth, Maria, additional, Roffe, Christine, additional, Rosenbaum, Sverre, additional, Rosso, Charlotte, additional, Röther, Joachim, additional, Rozanski, Michal, additional, Ruiz de Morales, Noelia, additional, Russo, Francesca, additional, Rutgers, Matthieu, additional, Sagnier, Sharmilla, additional, Samson, Yves, additional, Sánchez, Josep, additional, Sauer, Tamara, additional, Schäfer, Jan H., additional, Schieber, Simon, additional, Schill, Josef, additional, Schlak, Dennis, additional, Schlemm, Ludwig, additional, Schmidt, Sein, additional, Schonewille, Wouter, additional, Schröder, Julian, additional, Schulz, Andreas, additional, Schurig, Johannes, additional, Schwarting, Sönke, additional, Schwarz, Alexander, additional, Schwarzbach, Christopher, additional, Seidel, Matthias, additional, Seiler, Alexander, additional, Sembill, Jochen, additional, Serena Leal, Joaquin, additional, Shetty, Ashit, additional, Sibon, Igor, additional, Simonsen, Claus Z., additional, Singer, Oliver, additional, Sivagnanaratham, Aravinth, additional, Smets, Ide, additional, Smith, Craig, additional, Soors, Peter, additional, Sprigg, Nikola, additional, Spruegel, Maximilian, additional, Stark, David, additional, Steinert, Susanne, additional, Stösser, Sebastian, additional, Stuermlinger, Markus, additional, Swinnen, Bart, additional, Tamazyan, Ruben, additional, Tembl, Jose, additional, Terceno Izaga, Mikel, additional, Thomalla, Götz, additional, Touze, Emmanuel, additional, Truelsen, Thomas, additional, Turc, Guillaume, additional, Turine, Gaetane, additional, Tütüncü, Serdar, additional, Tyrell, Pippa, additional, Ustrell, Xavier, additional, Vadot, Wilfried, additional, Vallet, Anne-Evelyne, additional, Vallet, Pauline, additional, van den Berg, Lucie, additional, van den Berg, Sophie, additional, van Eendenburg, Cecile, additional, Van Hooff, Robbert-Jan, additional, van Sloten, Isabelle, additional, Vanacker, Peter, additional, Vancaester, Evelien, additional, Vanderdonckt, Patrick, additional, Vandermeeren, Yves, additional, Vanhee, Frederik, additional, Veltkamp, Roland, additional, Vestergaard, Karsten, additional, Viguier, Alain, additional, Vilas, Dolores, additional, Villringer, Kersten, additional, Voget, Dieke, additional, von Schrader, Jörg, additional, von Weitzel, Paul, additional, Warburton, Elisabeth, additional, Weber, Claudia, additional, Weber, Jörg, additional, Wegscheider, Karl, additional, Wegscheider, Mirko, additional, Weimar, Christian, additional, Weinstich, Karin, additional, Weise, Christopher, additional, Weise, Gesa, additional, Willems, Chris, additional, Winder, Klemens, additional, Wittayer, Matthias, additional, Wolf, Marc, additional, Wolf, Martin, additional, Wolff, Valerie, additional, Wollboldt, Christian, additional, Wollenweber, Frank, additional, Wouters, Anke, additional, Yalo, Bertrand, additional, Yger, Marion, additional, Younan, Nadia, additional, Yperzeele, Laetita, additional, Zegarac, Vesna, additional, Zeiner, Pia, additional, Ziemann, Ulf, additional, Zonneveld, Thomas, additional, Zuber, Mathieu, additional, Akutsu, Tsugio, additional, Aoki, Junya, additional, Arakawa, Shuji, additional, Doijiri, Ryosuke, additional, Egashira, Yusuke, additional, Enomoto, Yukiko, additional, Furui, Eisuke, additional, Furuta, Konosuke, additional, Gotoh, Seiji, additional, Hamasaki, Toshimitsu, additional, Hasegawa, Yasuhiro, additional, Hirano, Teryuki, additional, Homma, Kazunari, additional, Ichijyo, Masahiko, additional, Ide, Toshihiro, additional, Igarashi, Shuichi, additional, Iguchi, Yasuyuki, additional, Ihara, Masafumi, additional, Ikenouchi, Hajime, additional, Inoue, Tsuyoshi, additional, Itabashi, Ryo, additional, Ito, Yasuhiro, additional, Iwama, Toru, additional, Kamiyama, Kenji, additional, Kamiyoshi, Shoko, additional, Kanai, Haruka, additional, Kanematsu, Yasuhisa, additional, Kanzawa, Takao, additional, Kimura, Kazumi, additional, Kitayama, Jiro, additional, Kitazono, Takanari, additional, Kondo, Rei, additional, Kudo, Kohsuke, additional, Kusumi, Masayoshi, additional, Kuwahara, Ken, additional, Matsumoto, Shoji, additional, Matsuoka, Hideki, additional, Mihara, Ban, additional, Minematsu, Kazuo, additional, Miura, Ken, additional, Morita, Naomi, additional, Mouri, Wataru, additional, Murata, Kayo, additional, Nagakane, Yoshinari, additional, Nakase, Taizen, additional, Ohara, Hiromi, additional, Ohara, Nobuyuki, additional, Ohnishi, Hideyuki, additional, Ohta, Hajime, additional, Ohtaki, Masafumi, additional, Ohtani, Ryo, additional, Ohtsuki, Toshiho, additional, Ohyama, Hideo, additional, Okada, Takashi, additional, Okada, Yasushi, additional, Osaki, Masato, additional, Sakai, Nobuyuki, additional, Sanbongi, Yoshiki, additional, Sasaki, Naoshi, additional, Sasaki, Makoto, additional, Sato, Shoichiro, additional, Seki, Kenta, additional, Shimizu, Wataru, additional, Shiokawa, Yoshiaki, additional, Sozu, Takashi, additional, Suzuki, Junichiro, additional, Suzuki, Rieko, additional, Takagi, Yasushi, additional, Takizawa, Shunya, additional, Tanahashi, Norio, additional, Tanaka, Eijiro, additional, Tanaka, Ryota, additional, Tateishi, Yohei, additional, Terada, Tomoaki, additional, Terasaki, Tadashi, additional, Todo, Kenichi, additional, Tokunaga, Azusa, additional, Tsujino, Akira, additional, Ueda, Toshihiro, additional, Uesaka, Yoshikazu, additional, Uotani, Mihoko, additional, Urabe, Takao, additional, Watanabe, Masao, additional, Yagita, Yoshiki, additional, Yakushiji, Yusuke, additional, Yasui, Keizo, additional, Yonehara, Toshiro, additional, Yoshimura, Shinichi, additional, Aarnio, K., additional, Alemseged, F., additional, Anderson, C., additional, Ang, T., additional, Archer, M.L., additional, Attia, J., additional, Bailey, P., additional, Balabanski, A., additional, Barber, A., additional, Barber, P.A., additional, Bernhardt, J., additional, Bivard, A., additional, Blacker, D., additional, Bladin, C.F., additional, Brodtmann, A., additional, Cadilhac, D., additional, Campbell, B.C.V., additional, Carey, L., additional, Celestino, S., additional, Chan, L., additional, Chang, W.H., additional, ChangI, A., additional, Chen, C.H., additional, Chen, C.-I., additional, Chen, H.F., additional, Chen, T.C., additional, Chen, W.H., additional, Chen, Y.Y., additional, Cheng, C.A., additional, Cheong, E., additional, Chiou, Y.W., additional, Choi, P.M., additional, Chu, H.J., additional, Chuang, C.S., additional, Chung, T.C., additional, Churilov, L., additional, Clissold, B., additional, Connelly, A., additional, Coote, S., additional, Coulton, B., additional, Cowley, E., additional, Cranefield, J., additional, Curtze, S., additional, D'Este, C., additional, Davis, S.M., additional, Day, S., additional, Desmond, P.M., additional, Dewey, H.M., additional, Ding, C., additional, Donnan, G.A., additional, Drew, R., additional, Eirola, S., additional, Field, D., additional, Frost, T., additional, Garcia-Esperon, C., additional, George, K., additional, Gerraty, R., additional, Grimley, R., additional, Guo, Y.C., additional, Hankey, G., additional, Harvey, J., additional, Ho, S.C., additional, Hogan, K., additional, Howells, D., additional, Hsiao, P.M., additional, Hsu, C.H., additional, Hsu, C.T., additional, Hsu, C.-S., additional, Hsu, J.P., additional, Hsu, Y.D., additional, Hsu, Y.T., additional, Hu, C.J., additional, Huang, C.C., additional, Huang, H.Y., additional, Huang, M.Y., additional, Huang, S.C., additional, Huang, W.S., additional, Jackson, D., additional, Jeng, J.S., additional, Jiang, S.K., additional, Kaauwai, L., additional, Kasari, O., additional, King, J., additional, Kleinig, T.J., additional, Koivu, M., additional, Kolbe, J., additional, Krause, M., additional, Kuan, C.W., additional, Kung, W.L., additional, Kyndt, C., additional, Lau, C.L., additional, Lee, A., additional, Lee, C.Y., additional, Lee, J.T., additional, Lee, Y., additional, Lee, Y.C., additional, Levi, C., additional, Levi, C.R., additional, Lien, L.M., additional, Lim, J.C., additional, Lin, C.C., additional, Lin, C.H., additional, Lin, C.M., additional, Lin, D., additional, Liu, C.H., additional, Liu, J., additional, Lo, Y.C., additional, Loh, P.S., additional, Low, E., additional, Lu, C.H., additional, Lu, C.J., additional, Lu, M.K., additional, Ly, J., additional, Ma, H., additional, Macaulay, L., additional, Macdonnell, R., additional, Mackey, E., additional, Macleod, M., additional, Mahadevan, J., additional, Maxwell, V., additional, McCoy, R., additional, McDonald, A., additional, McModie, S., additional, Meretoja, A., additional, Mishra, S., additional, Mitchell, P.J., additional, Miteff, F., additional, Moore, A., additional, Muller, C., additional, Ng, F., additional, Ng, F.C., additional, Ng, J-L., additional, O'Brian, W., additional, O'Collins, V., additional, Oxley, T.J., additional, Parsons, M.W., additional, Patel, S., additional, Peng, G.S., additional, Pesavento, L., additional, Phan, T., additional, Rodrigues, E., additional, Ross, Z., additional, Sabet, A., additional, Sallaberger, M., additional, Salvaris, P., additional, Shah, D., additional, Sharma, G., additional, Sibolt, G., additional, Simpson, M., additional, Singhal, S., additional, Snow, B., additional, Spratt, N., additional, Stark, R., additional, Sturm, J., additional, Sun, M.C., additional, Sun, Y., additional, Sung, P.S., additional, Sung, Y.F., additional, Suzuki, M., additional, Tan, M., additional, Tang, S.C., additional, Tatlisumak, T., additional, Thijs, V., additional, Tiainen, M., additional, Tsai, C.H., additional, Tsai, C.K., additional, Tsai, C.L., additional, Tsai, H.T., additional, Tsai, L.K., additional, Tseng, C.H., additional, Tseng, L.T., additional, Tsoleridis, J., additional, Tu, H., additional, Tu, H.T-H., additional, Vallat, W., additional, Virta, J., additional, Wang, W.C., additional, Wang, Y.T., additional, Waters, M., additional, Weir, L., additional, Wijeratne, T., additional, Williams, C., additional, Wilson, W., additional, Wong, A.A., additional, Wong, K., additional, Wu, T.Y., additional, Wu, Y.H., additional, Yan, B., additional, Yang, F.C., additional, Yang, Y.W., additional, Yassi, N., additional, Yeh, H.L., additional, Yeh, J.H., additional, Yeh, S.J., additional, Yen, C.H., additional, Young, D., additional, Ysai, C.L., additional, Zhang, W.W., additional, Zhao, H., additional, Zhao, L., additional, Althaus-Knaurer, Katharina, additional, Berrouschot, Jörg, additional, Bluhmki, Erich, additional, Bovi, Paolo, additional, Chatellier, Gilles, additional, Cove, Lynda, additional, Davis, Stephen, additional, Dixit, A., additional, Donnan, Geoffrey, additional, Ehrenkrona, Christina, additional, Eschenfelder, Christoph, additional, Fatar, Marc, additional, Francisco Arenillas, Juan, additional, Gruber, Franz, additional, Kala, Lalit, additional, Kapeller, Peter, additional, Kaste, Markku, additional, Kessler, Christof, additional, Köhrmann, Martin, additional, Laage, Rico, additional, Lees, Kennedy R., additional, Luna Rodriguez, Alain, additional, Mas, Jean-Louis, additional, Mikulik, Robert, additional, Molina, Carlos, additional, Muddegowda, Girish, additional, Muir, Keith, additional, Niederkorn, Kurt, additional, Nuñez, Xavier, additional, Schellinger, Peter, additional, Serena, Joaquin, additional, Sobesky, Jan, additional, Steiner, Thorsten, additional, Svenson, Ann-Sofie, additional, von Kummer, Rüdiger, additional, Wardlaw, Joanna, additional, Betensky, Rebecca A., additional, Boulouis, Gregoire, additional, Carandang, Raphael A., additional, Copen, William A., additional, Cougo, Pedro, additional, Cutting, Shawna, additional, Drake, Kendra, additional, Ford, Andria L., additional, Hallenbeck, John, additional, Harris, Gordon J., additional, Hoesch, Robert, additional, Hsia, Amie, additional, Kase, Carlos, additional, Latour, Lawrence, additional, Lev, Michael H., additional, Muzikansky, Alona, additional, Nagaraja, Nandakumar, additional, Schwamm, Lee H., additional, Searls, Eric, additional, Song, Shlee S., additional, Starkman, Sidney, additional, Yoo, Albert J., additional, and Zand, Ramin, additional

Published
2020
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21. Additional file 1: of Significance of arterial spin labeling perfusion and susceptibility weighted imaging changes in patients with transient ischemic attack: a prospective cohort study

Author

Havsteen, Inger, Willer, Lasse, Ovesen, Christian, Nybing, Janus, Ægidius, Karen, Marstrand, Jacob, Meden, Per, Rosenbaum, Sverre, Folke, Marie, Christensen, Hanne, and Christensen, Anders

Abstract

Supplementary methodology. Motion artefact assessment. Supplemental results. Table S1. Combinations of number of planes and images affected by subject motion for n = 116 patients. Table S2. Large vessel findings for patients (n = 116) stratified after most likely etiology after full radiological and clinical workup. Table S3. Risk of persistent infarction signs for DWI lesions and perfusion findings. (DOCX 20 kb)

Published
2018
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22. Additional file 2: of Significance of arterial spin labeling perfusion and susceptibility weighted imaging changes in patients with transient ischemic attack: a prospective cohort study

Author

Havsteen, Inger, Willer, Lasse, Ovesen, Christian, Nybing, Janus, ÆGidius, Karen, Marstrand, Jacob, Meden, Per, Rosenbaum, Sverre, Folke, Marie, Christensen, Hanne, and Christensen, Anders

Abstract

Figure S1. ASL interpretability and artefact description for 116 patients. Top 4 rows compare ASL PWI and relCBF images. Bottom row shows ring artefact frequency. GWâ =â gray-white matter discrimination. (PDF 4 kb)

Published
2018
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23. Sphenopalatine Ganglion Stimulation to Augment Cerebral Blood Flow

Author

Bornstein, Natan M., primary, Saver, Jeffrey L., additional, Diener, Hans-Christoph, additional, Gorelick, Philip B., additional, Shuaib, Ashfaq, additional, Solberg, Yoram, additional, Devlin, Thomas, additional, Leung, Thomas, additional, Molina, Carlos A., additional, Skoloudik, David, additional, Fiksa, Jan, additional, Krieger, Derk, additional, Andersen, Grethe, additional, Berrouschot, Joerg, additional, Hobohm, Carsten, additional, Schneider, Dietmar, additional, Griewing, Bernd, additional, Endres, Matthias, additional, Hausler, Karl-Georg, additional, Kimmig, Hubert, additional, Ringleb, Peter, additional, Weimar, Christian, additional, Schilling, Matthias, additional, Kohrmann, Martin, additional, Hetzel, Andreas, additional, Kaps, Manfred, additional, Cheung, Raymond, additional, Sobolewski, Piotr, additional, Nyke, Walenty, additional, Czlonkowska, Anna, additional, Stepien, Adam, additional, Waldemar, Brola, additional, Słowik, Agnieszka, additional, Zbigniewem, Stelmasiakiem, additional, Lubiński, Ignacy, additional, Portela, Pedro, additional, Segure, Tomas, additional, Marti-Fabregas, Joan, additional, Alonso, Maria, additional, Nunez, Antonio, additional, Miguel, Miguel Blanco, additional, Campello, Anna, additional, Arenillas, Joaquin, additional, Marshall, Nash, additional, Chiu, David, additional, Shownkeen, Harish, additional, Rymer, Marilyn, additional, Sen, Souvik, additional, Roubec, Martin, additional, Kuliha, Martin, additional, Lakomý, Ctirad, additional, Tyl, David, additional, Kemlink, David, additional, Doležal, Ondřej, additional, Rekova, Petra, additional, Krejčí, Veronika, additional, Christensen, Anders, additional, Belhage, Bo, additional, Maschmann, Christian, additional, Kruse Larsen, Christian, additional, Pott, Frank, additional, Christensen, Hanne, additional, Marstrand, Jakob, additional, Nielsen, Jens Kjellberg, additional, Meden, Per, additional, Prytz, Svend, additional, Rosenbaum, Sverre, additional, Hedemann Sorensen, Jens Christian, additional, Stenhoj Meier, Kaare, additional, Schmift Ettrup, Kare, additional, Dupont Hougaard, Kristina, additional, Von Wietzel, Paul, additional, Stoll, Anett, additional, Schwetlick, Hans, additional, Pradel, Hendirk, additional, Hemprich, Alexander, additional, Schulz, Andreas, additional, Frerich, Bernhard, additional, Weise, Christopher, additional, Michalski, Dominik, additional, Schaller, Felix, additional, Schiefke, Franziska, additional, Helmrich, Jens, additional, Pelz, Johann, additional, Schnieder, Martin, additional, Schneider, Martin, additional, Matzen, Peter, additional, Langos, Rudiger, additional, Müller-Duerwald, Stephan, additional, Lukhaup, Sven, additional, Bauer, Ute, additional, Kloppig, Wolfgang, additional, Hiermann, Erich, additional, Mucha, Gregor, additional, Soda, Hassan, additional, Weinhardt, Renate, additional, Mucha, Teresa, additional, Ziegler, Volker, additional, Abbushi, Alexander, additional, Hotter, Benjamin, additional, Winter, Benjamin, additional, Anthofer, Birgit, additional, Noack, Cornelia, additional, Laubisch, Dinah, additional, Heldge Schneider, Gerd, additional, Jan Jungehulsing, Gerhard, additional, Mueller, Heiko, additional, Dreier, Jens, additional, Fiebach, Jochen, additional, Flechsenhar, Julia, additional, Villringer, Kersten, additional, Ebinger, Martin, additional, Rozanski, Michael, additional, Vajkoczy, Peter, additional, Klingebiel, Randolf, additional, Steinicke, Robert, additional, Pittl, Sandra, additional, Hoffmann, Sarah, additional, Maul, Stephan, additional, Krause, Thomas, additional, Liman, Thomas, additional, Plath, Thomas, additional, Nowe, Tim, additional, Schmidt, Wolf, additional, Fritzsch, Carsten, additional, Haas, Christopher, additional, Will, Hans-Gerd, additional, Haußmann-Betz, Katja, additional, Bayat, Mohsen, additional, Pordzik, Tomazs, additional, Hug, Andreas, additional, Staff, Christian Jürgen, additional, Lichy, Christoph, additional, Eggers, Georg, additional, Kloss, Manja, additional, Bendszus, Martin, additional, Herrmann, Oliver, additional, Seeberger, Robin, additional, Schwarting, Soenke, additional, Rhode, Stefan, additional, Rizos, Timolaos, additional, Hacke, Werner, additional, Frank, Benedikt, additional, Bozkurt, Bessi, additional, Holle, Dagny, additional, Mueller, Daniel, additional, Koch, Dirk, additional, Shanib, Hind, additional, Sudendey, Joachim, additional, Brenck, Johannes, additional, Busch, Kolja, additional, Gartzen, Kristina, additional, Gasser, Thomas, additional, Hagenacker, Tim, additional, Buerke, Boris, additional, Prigge, Gudrun, additional, Minnerup, Jens, additional, Albers, Johannes, additional, Wermker, Kai, additional, Schwindt, Wolfram, additional, Kallmünzer, Ringlestein, Bernd, additional, Hauer, Eva, additional, Breuer, Lorenz, additional, Schellinger, Peter, additional, Kollmar, Rainer, additional, Sauer, Roland, additional, Schwab, Stefan, additional, Struffert, Tobias, additional, Funfack, Anette, additional, Stechmann, Anne, additional, Schlaeger, Axel, additional, Laeppchen, Claus, additional, Schuchardt, Florian, additional, Klingler, Jan-Helge, additional, Reis, Janine, additional, Lambeck, Johann, additional, Friedrich, Mirko, additional, Laible, Mona, additional, Wellermeyer, Philip, additional, Beck, Sandra, additional, Rutsch, Sebastian, additional, Niesen, Wolf-Dirk, additional, Tanislav, Christian, additional, Schaaf, Heidrun, additional, Kerkmann, Heiko, additional, Schirotzek, Ingo, additional, Allendörfer, Jens, additional, Wolff, Stephanie, additional, Yuk-Lun Lau, Alexander, additional, Yin Yan Chan, Anne, additional, Siu, Deyond, additional, Wong, Edward HC, additional, Chu Wong, George Kwok, additional, Leung, Howan, additional, Wong, Lawrence K.S., additional, Zhu, Xian Lun, additional, Yan Soo, Yannie Oi, additional, Ting Tse, Alan Choi, additional, Kit Leung, Gilberto Ka, additional, Leung, Kar Ming, additional, Ngai Hung, Kwan, additional, Wai Mei Kwan, May, additional, Man Yu Tse, Mona, additional, Tse, Philip, additional, Hon Chan, Ping, additional, Lee, Raymand, additional, Shek Kwan Chang, Richard, additional, Yin Yu Pang, Shirley, additional, Fong Kwong Hon, Sonny, additional, Cheng, Tat Sun, additional, Lui, Wai Man, additional, Wo Mak, Windsor Wai, additional, Sobota, Anna, additional, Wiater, Baeta, additional, Loch, Barbara, additional, Wolak, Genowefa, additional, Łabudzka, Irena, additional, Dabal, Jan, additional, Grzesik, Marcin, additional, Sledzinska, Monika, additional, Hatalska-Żerebiec, Renata, additional, Szczuchniak, Wiktor, additional, Gójska, Anna, additional, Nałęcz, Dariusz, additional, Gasecki, Dariusz, additional, Kozera, Grzegorz, additional, Dylewicz, Łukasz, additional, Niekra, Marcin, additional, Kwarciany, Mariusz, additional, Chomik, Piotr, additional, Skowron, Piotr, additional, Kobayashi, Adam, additional, Chabik, Grzegorz, additional, Makowicz, Grzegorz, additional, Bembenek, Jan, additional, Jędrzejewska, Julia, additional, Karlinski, Michal, additional, Czepiel, Wojciech, additional, Brodacki, Bogdan, additional, Staszewski, Jacek, additional, Kosek, Jarosław, additional, Jadczak, Marcin, additional, Durka-Kęsy, Marta, additional, Kaluzny, Krzysztof, additional, Ziomek, Małgorzata, additional, Fudala, Małgorzata, additional, Sosnowski, Zbigniew, additional, Ferens, Antoni, additional, Szczygieł, Elżbieta, additional, Banaszkiewicz, Krzysztof, additional, Ziomek, Maciej, additional, Wnuk, Marcin, additional, Szczepańska-Szerej, Anna, additional, Jach, Ewa, additional, Maslanko, Grazyna Elzbieta, additional, Wojczal, Joanna, additional, Luchowski, Piotr, additional, Kowalczyk, Andrzej, additional, Jakubiak, Jerzy, additional, Kopcewicz, Joanna, additional, Gajda, Maciej, additional, Wichlinska-Lubinska, Malgorzata, additional, Rodriguez, David, additional, Santamarin, Estevo, additional, Pagola, Jorge, additional, Lorente Guerrero, Juan, additional, Ribo, Marc, additional, Rubiera, Marta, additional, Maisterra, Olga, additional, Pinero, Soccoro, additional, Catalina Iglesias, Valera, additional, Plans, Gerard, additional, Quesada, Helena, additional, Aparicio Caballero, Marco Alberto, additional, Portela, Pedro Cardona, additional, De Diego, Antonio Belinchon, additional, Garay, David Sopelana, additional, García Rodriguez, Máximo Rafael, additional, Martin, Oscar Ayo, additional, Braña, Silvia Crusat, additional, Garcia, Jorge, additional, Hernandez, Fernando Munoz, additional, Catala, Ignasi, additional, Marti-Vilalta, Josep Lluis, additional, Delgado Mederos, Rachel, additional, de Quintana, Schmid Cristian, additional, Martinez-Ramirez, Sergi, additional, Valcarcel Gonzalez, Jaime, additional, Masjuan Vallejo, Jaime, additional, Diamantopoulus, Jorge, additional, Del Alamo, Marta, additional, Poveda, Pedro Domingo, additional, Pastor, Andres Garcia, additional, Carballal, Calros Fernandez, additional, Diaz, Fernando, additional, Garcia Leal, Roberto, additional, Juretschke, Ruiz, additional, Echabe, Eduardo Arán, additional, Sanchez, Jose Castillo, additional, Yanez, Manuel Rodriguez, additional, Garcia, Ramon Serramito, additional, Muino, Rogelio Leira, additional, Rivas, Susana Arias, additional, Lopez Gonzalez, Demian Manzano, additional, Cuadrado, Elisa, additional, Giralt, Eva, additional, Villalba, Gloria, additional, Roquer, Jaime, additional, Angel, Ois, additional, Jimenez, Maria, additional, Cedeño, René Robles, additional, Salinas, Ruy, additional, Lejarreta, Saioa, additional, Silva, Yolanda, additional, Fraile, Adela, additional, Calleja, Ana, additional, Cepeda Landínez, Guillermo Arturo, additional, Tellez, Nieves, additional, Garcia Bermejo, Pablo, additional, Santos, Pérez Jaime, additional, Herranz, Rosa Fernandez, additional, Hunt, Peter, additional, Browning, Donald, additional, Violette, Michael, additional, Hoddeson, Robert, additional, Rose, James, additional, Zhang, Jonathan, additional, Mazumdar, Avi, additional, Echiverri, Henri, additional, Chow, James, additional, Lovick, Darren, additional, Coleman, Martin, additional, Akhtar, Naveed, additional, Sugg, Rebecca, additional, Zanation, Adam, additional, Germanwala, Anand, additional, Senior, Brent, additional, Huang, David, additional, Aucutt-Walter, Natalie, additional, Kasner, Scott, additional, LeRoux, Peter, additional, von Kummer, Rüdiger, additional, and Palesch, Yuko, additional

Published
2019
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25. Small cortical grey matter lesions show no persistent infarction in transient ischaemic attack? A prospective cohort study

Author

Havsteen, Inger, primary, Ovesen, Christian, additional, Willer, Lasse, additional, Nybing, Janus Damm, additional, Ægidius, Karen, additional, Marstrand, Jacob, additional, Meden, Per, additional, Rosenbaum, Sverre, additional, Folke, Marie Norsker, additional, Christensen, Hanne, additional, and Christensen, Anders, additional

Published
2018
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26. Comparison of 3- and 20-Gradient Direction Diffusion-Weighted Imaging in a Clinical Subacute Cohort of Patients with Transient Ischemic Attack: Application of Standard Vendor Protocols for Lesion Detection and Final Infarct Size Projection

Author

Havsteen, Inger, primary, Ovesen, Christian, additional, Willer, Lasse, additional, Nybing, Janus Damm, additional, Ægidius, Karen, additional, Marstrand, Jacob, additional, Meden, Per, additional, Rosenbaum, Sverre, additional, Folke, Marie Norsker, additional, Christensen, Hanne, additional, and Christensen, Anders, additional

Published
2017
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31. Abstract 209: Final Results of the Surprise Study:Long-term Monitoring For Atrial Fibrillation (AF) in Cryptogenic Stroke

Author

Christensen, Louisa M, primary, Krieger, Derk, additional, Højberg, Søren, additional, Pedersen, Ole D, additional, Karlsen, Finn M, additional, Jacobsen, Michael D, additional, Worch, René, additional, Nielsen, Henrik, additional, Ægidius, Karen, additional, Rosenbaum, Sverre, additional, Marstrand, Jakob, additional, Biering-Sørensen, Tor, additional, Willer, Lasse, additional, and Christensen, Hanne, additional

Published
2013
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32. Abstract 153: Long-term Monitoring For Paroxystic Atrial Fibrillation In Cryptogenic Stroke: Preliminary Results Of The Surprise Study

Author

Christensen, Louisa M, primary, Krieger, Derk, additional, Højberg, Søren, additional, Pedersen, Ole D., additional, Karlsen, Finn Michael, additional, Worch, René, additional, Nielsen, Henrik, additional, Ægidius, Karen, additional, Rosenbaum, Sverre, additional, Marstrand, Jakob, additional, and Christensen, Hanne, additional

Published
2012
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37. Abstract 209.

Author

Christensen, Louisa M, Krieger, Derk, H⊘jberg, S⊘ren, Pedersen, Ole D, Karlsen, Finn M, Jacobsen, Michael D, Worch, René, Nielsen, Henrik, Ægidius, Karen, Rosenbaum, Sverre, Marstrand, Jakob, Biering-S⊘rensen, Tor, Willer, Lasse, and Christensen, Hanne

Published
2013

38. Abstract 153.

Author

Christensen, Louisa M, Krieger, Derk, H⊘jberg, S⊘ren, Pedersen, Ole D., Karlsen, Finn Michael, Worch, René, Nielsen, Henrik, Ægidius, Karen, Rosenbaum, Sverre, Marstrand, Jakob, and Christensen, Hanne

Published
2012

39. [Severe cerebral haemodynamic impairment treated with bypass surgery].

Author

Sagar M, Stenør C, and Rosenbaum S

Subjects
Aged, Carotid Artery, Internal, Female, Hemodynamics, Humans, Arterial Occlusive Diseases, Cerebral Revascularization, Ischemic Attack, Transient
Abstract

Cerebral hypoperfusion due to steno-occlusive large artery disease poses a diagnostic challenge. This is a case report of a 72-year-old woman, presenting with recurring paroxysmal right-sided hemiparesis, dysphasia and occasionally limb-shaking transient ischaemic attacks, especially during orthostatic challenge. The condition was initially misdiagnosed as focal epilepsy. A workup revealed a left-sided carotid artery occlusion and a haemodynamic failure in the carotid distribution, seen on a 15O-H2O PET acetazolamid scan. The patient was successfully treated with an extracranial-intracranial bypass surgery.

Published
2021

40. Biomarkers and antithrombotic treatment in cervical artery dissection - Design of the TREAT-CAD randomised trial.

Author

Traenka C, Gensicke H, Schaedelin S, Luft A, Arnold M, Michel P, Kägi G, Kahles T, Nolte CH, Kellert L, Rosenbaum S, Sztaizel R, Brehm A, Stippich C, Psychogios M, Lyrer P, and Engelter ST

Abstract

Introduction: The type of antithrombotic treatment in cervical artery dissection patients is still a matter of debate. Most physicians prefer anticoagulants over antiplatelet agents for stroke prevention. However, this approach is not evidence-based and antiplatelets might be as safe and as effective. The 'Biomarkers and Antithrombotic Treatment in Cervical Artery Dissection' ('TREAT-CAD') trial (clinicaltrials.gov: NCT02046460) compares Aspirin to oral anticoagulants (vitamin K antagonists) with regard to efficacy and safety by using both clinical and imaging surrogate outcome measures. TREAT-CAD tests the hypothesis, that aspirin is as safe and effective as vitamin K antagonists., Patients and Methods: TREAD-CAD is a P rospective, R andomised controlled, O pen-labelled, multicentre, non-inferiority trial with B linded assessment of outcome E vents (PROBE-design). Key eligibility criteria are (i) clinical symptoms attributable to cervical artery dissection and (ii) verification of the cervical artery dissection diagnosis by established magnetic resonance imaging criteria. Patients are randomised to receive either Aspirin 300 mg daily or vitamin K antagonists for 90 days., Results: Primary outcomes are assessed at 14 ± 10 days (magnetic resonance imaging and clinical examination) and at 90 ± 30 days (clinical examinations). The primary endpoint is a composite outcome measure - labelled C erebrovascular I schemia, major H emorrhagic events or D eath (CIHD) - and includes (i) occurrence of any stroke (including retinal infarction), (ii) new ischaemic lesions on diffusion-weighted magnetic resonance imaging, (iii) any major extracranial haemorrhage, (iv) any symptomatic intracranial haemorrhage, (v) any new haemorrhagic lesion visible on paramagnetic-susceptible sequences and (vi) death., Discussion: After database closure, (i) central verification of cervical artery dissection diagnosis will be done by two experienced raters, (ii) adjudication of outcome events will be performed by independent adjudication committees, separately for clinical and imaging outcomes. The primary analysis will be done on the per protocol data set. The targeted sample size consists of 169 evaluable patients in the per protocol data set., Conclusion: TREAT-CAD is testing the non-inferiority of Aspirin versus vitamin K antagonists treatment in patients with symptomatic cervical artery dissection by combined clinical and magnetic resonance imaging outcomes., (© European Stroke Organisation 2020.)

Published
2020
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41. [Limb-shaking transient ischaemic attack].

Author

Henriksen AC, Marstrand J, Christensen H, and Rosenbaum S

Subjects
Antivenins therapeutic use, Humans, Tremor, Ischemic Attack, Transient drug therapy, Snake Bites complications, Snake Bites drug therapy
Abstract

Limb-shaking transient ischaemic attack (LS-TIA) is a symptom of cerebral haemodynamic failure caused by large vessel disease. LS-TIA often remains unrecognised though associated with a poor prognosis. The patient presents with irregular hemiform jerks caused by ischaemia. Imaging demonstrating reduced perfusion or/and flow is essential for the diagnosis, and treatment is aimed at reducing development in atherosclerosis and improving perfusion. As described in this review, management is focused optimising secondary prevention, and in selected cases surgical interventions are considered. Evidence remains weak, especially as to surgical interventions.

Published
2020

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