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5. Age-period-cohort modelling of type 1 diabetes incidence rates among children included in the EURODIAB 25-year follow-up study

Author

Svensson, J., primary, Ibfelt, E. H., additional, Carstensen, B., additional, Neu, A., additional, Cinek, O., additional, Skrivarhaug, T., additional, Rami-Merhar, B., additional, Feltbower, R. G., additional, Castell, C., additional, Konrad, D., additional, Gillespie, K., additional, Jarosz-Chobot, P., additional, Marčiulionytė, D., additional, Rosenbauer, J., additional, Bratina, N., additional, Ionescu-Tirgoviste, C., additional, Gorus, F., additional, Kocova, M., additional, de Beaufort, C., additional, and Patterson, C. C., additional

Published
2022
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9. Seasonal variation in month of diagnosis in children with type 1 diabetes registered in 23 European centers during 1989–2008: little short-term influence of sunshine hours or average temperature

Author

Patterson, CC, Gyürüs, E, Rosenbauer, J, Cinek, O, Neu, A, Schober, E, Parslow, RC, Joner, G, Svensson, J, Castell, C, Bingley, PJ, Schoenle, E, Jarosz-Chobot, P, Urbonaité, B, Rothe, U, Kržišnik, C, Ionescu-Tirgoviste, C, Weets, I, Kocova, M, Stipancic, G, Samardzic, M, de Beaufort, CE, Green, A, Soltész, G, and Dahlquist, GG

Published
2015
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10. Trends in childhood type 1 diabetes incidence in Europe during 1989–2008: evidence of non-uniformity over time in rates of increase

Author

Patterson, C. C., Gyürüs, E., Rosenbauer, J., Cinek, O., Neu, A., Schober, E., Parslow, R. C., Joner, G., Svensson, J., Castell, C., Bingley, P. J., Schoenle, E., Jarosz-Chobot, P., Urbonaité, B., Rothe, U., Krzisnik, C., Ionescu-Tirgoviste, C., Weets, I., Kocova, M., Stipancic, G., Samardzic, M., de Beaufort, C. E., Green, A, Dahlquist, G. G., and Soltész, G.

Published
2012
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12. Birthweight and the risk of childhood-onset type 1 diabetes: a meta-analysis of observational studies using individual patient data

Author

Cardwell, C. R., Stene, L. C., Joner, G., Davis, E. A., Cinek, O., Rosenbauer, J., Ludvigsson, J., Castell, C., Svensson, J., Goldacre, M. J., Waldhoer, T., Polanska, J., Gimeno, S. G. A., Chuang, L.-M., Parslow, R. C., Wadsworth, E. J. K., Chetwynd, A., Pozzilli, P., Brigis, G., Urbonaitė, B., Šipetić, S., Schober, E., Ionescu-Tirgoviste, C., de Beaufort, C. E., Stoyanov, D., Buschard, K., and Patterson, C. C.

Published
2010
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14. Assoziation zwischen dem Risiko einer diabetischen Ketoazidose und der regionalen Inzidenz von COVID-19-Fällen und Todesfällen bei Kindern und Jugendlichen mit neu aufgetretenem Typ-1-Diabetes während der ersten Welle der Pandemie in Deutschland

Author

Kamrath, C, additional, Rosenbauer, J, additional, Eckert, A, additional, Pappa, A, additional, Reschke, F, additional, Rohrer, T, additional, Mönkemöller, K, additional, Wurm, M, additional, Hake, K, additional, Raile, K, additional, and Holl, RW, additional

Published
2021
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18. The Transatlantic HbA1c gap : differences in glycaemic control across the lifespan between people included in the US T1D Exchange Registry and those included in the German/Austrian DPV registry

Author

Hermann, Julia M., Miller, K. M., Holl, R. W., Maahs, D. M., T1D Exchange Clinic Network and the DPV initiative, Hofer, S. E., Clements, M. A., Karges, Wolfram, Foster, N. C., Fröhlich-Reiterer, E., Rickels, M. R., Rosenbauer, J., and DeSalvo, D. J.

Subjects
ddc:610
Published
2020
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19. Associations of area deprivation and urban/rural traits with the incidence of type 1 diabetes: Analysis at the municipality level in North Rhine-Westphalia, Germany

Author

Castillo-Reinado, K., Maier, W., Holle, R., Stahl-Pehe, A., Baechle, C., Kuss, O., Hermann, J., Holl, R.W., Rosenbauer, J., and The German Pediatric Surveillance Unit (ESPED

Subjects
Employment, Male, Rural Population, Adolescent, Urban Population, Endocrinology, Diabetes and Metabolism, Population, Crude incidence, 030209 endocrinology & metabolism, Multiple deprivation, Environment, Young Adult, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, Endocrinology, Residence Characteristics, Germany, Diabetes mellitus, Internal Medicine, Humans, Medicine, Area deprivation, 030212 general & internal medicine, Poisson regression, Child, education, Population Density, Spatial Analysis, education.field_of_study, Type 1 diabetes, business.industry, Incidence, Infant, Newborn, Infant, medicine.disease, Diabetes Mellitus, Type 1, Child, Preschool, Relative risk, Income, symbols, Educational Status, Social Capital, Female, Safety, business, Demography
Abstract

AIM To analyse the associations of area deprivation and urban/rural traits with the incidence of type 1 diabetes in the German federal state of North Rhine-Westphalia. METHODS Data of incident type 1 diabetes cases in children and adolescents aged

Published
2020

33. The transatlantic HbA1c gap : differences in glycaemic control across the lifespan between people included in the US T1D Exchange Registry and those included in the German/Austrian DPV registry

Author

Hermann, Julia M., Miller, K. M., Hofer, S. E., Karges, W., Foster, N. C., Fröhlich-Reiterer, E., Rickels, M. R., Rosenbauer, J., DeSalvo, D. J., Holl, Reinhard, Maahs, D. M., European Union (EU), and Horizon 2020

Subjects
Registry, T1DX, Lifespan, DPV, Diabetes mellitus Typ 1, Langzeit-Blutzuckermessung, Kohortenanalyse, Real-world data, Type 1 diabetes, Diabetes mellitus, Type 1, Glycated hemoglobin A, Glycaemic control, Cohort studies, ddc:610
Published
2019

45. The Transatlantic HbA1c gap: differences in glycaemic control across the lifespan between people included in the US T1D Exchange Registry and those included in the German/Austrian DPV registry.

Author

Hermann, J. M., Miller, K. M., Hofer, S. E., Clements, M. A., Karges, W., Foster, N. C., Fröhlich‐Reiterer, E., Rickels, M. R., Rosenbauer, J., DeSalvo, D. J., Holl, R. W., and Maahs, D. M.

Subjects
AGE distribution, ETHNIC groups, GLYCOSYLATED hemoglobin, INSULIN, INSULIN pumps, TYPE 1 diabetes, SEX distribution, MULTIPLE regression analysis, HEALTH equity, GLYCEMIC control
Abstract

Aim: To compare HbA1c levels across the lifespan in people with type 1 diabetes in the USA with those in Germany/Austria, and to examine potential differences in HbA1c levels between sexes, insulin delivery methods and minority status. Methods: Data were extracted from the US T1D Exchange Registry (n=18 381 participants from 73 sites) and from the German/Austrian Prospective Diabetes Follow‐up Registry, the DPV (n=32 643 participants from 362 sites). Mean HbA1c was calculated for each year of age for individuals aged ≤25 years, and at 2‐year age intervals for individuals aged >25 years. Curves for mean HbA1c by age were estimated using locally weighted scatterplot smoothing. HbA1c differences between registries, sexes, insulin delivery methods, and minority status were assessed by age group using multiple linear regression. Results: In both registries, mean HbA1c increased by ~11 mmol/mol (1.0%) between the ages of 9 and 18 years, although at quite different absolute levels: from 66 mmol/mol (8.2%) to 77 mmol/mol (9.2%) in the T1D Exchange Registry, and from 56 mmol/mol (7.3%) to 66 mmol/mol (8.2%) in the DPV. Sex differences were observed in the DPV only. In the T1D Exchange Registry, injection users had higher mean HbA1c than pump users across the lifespan, whereas in the DPV higher HbA1c levels in injection users were observed in the age groups 6 to <12 years, 12 to <18 years, and 30 to <50 years (P < 0.001). Minority status was significantly associated with higher HbA1c in most age groups in both registries. Conclusions: Significant differences in HbA1c were noted between the USA and Germany/Austria, with disparities more pronounced in early childhood through to young adulthood. Further studies should identify causes for these disparities. What's new?: Data from the TID Exchange Registry (T1DX) have shown that only few individuals with type 1 diabetes meet HbA1c targets, and that glycaemic control has worsened in adolescents over recent years.Although a similar increase in HbA1c on reaching adolescence was observed, young people in the German/Austrian DPV registry had HbA1c levels that were ˜11 mmol/mol (1.0%) lower compared with young people included in the T1DX.Comparison of the two contemporary diabetes cohorts showed large discrepancies in glycaemic control between developed Western countries, and highlights the need for increased efforts to improve care and particularly to lower HbA1c in young people with type 1 diabetes, especially those included in the T1DX. [ABSTRACT FROM AUTHOR]

Published
2020
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46. Evaluation of lipoprotein‐associated phospholipase A2 as a marker for renal microvasculopathy in adolescents with Type 1 diabetes.

Author

Seyfarth, J., Herebian, D., Reinauer, C., Baechle, C., Roden, M., Holl, R. W., Reinehr, T., Mayatepek, E., Meissner, T., and Rosenbauer, J.

Subjects
VASCULAR disease diagnosis, KIDNEY disease diagnosis, KIDNEY disease risk factors, ALBUMINURIA, BIOMARKERS, BLOOD collection, VASCULAR diseases, ESTERASES, HIGH density lipoproteins, TYPE 1 diabetes, KIDNEY diseases, PHOSPHOLIPIDS, RISK assessment, SEX distribution, STATISTICS, MULTIPLE regression analysis, OXIDATIVE stress, CROSS-sectional method, GLYCEMIC control, DISEASE complications, DISEASE risk factors
Abstract

Aim: To assess the relevance of lipoprotein‐associated phospholipase A2 activity as a diagnostic and prognostic marker for renal microvascular diseases. Methods: We analysed lipoprotein‐associated phospholipase A2 activity and lysophosphatidylcholine levels (as a surrogate marker of oxidative stress) in 165 adolescents (aged 17.0 ± 2.3 years) with a history of Type 1 diabetes greater than 10 years. Clinical data were obtained from the German/Austrian nationwide Diabetes‐Patients Follow‐up (DPV) registry at blood collection and on average 2.4 ± 1.3 years later at follow‐up. Relationships between lipoprotein‐associated phospholipase A2 activity and clinical, demographic and laboratory variables, lysophosphatidylcholine levels and presence of albuminuria were evaluated by multivariable linear and logistic regression. Results: Lipoprotein‐associated phospholipase A2 activity was higher in male than female adolescents (P = 0.002). Albuminuria was present in 14% (22/158) of participants at baseline, and 5% (4/86) of participants without albuminuria at baseline developed albuminuria until follow‐up. Lipoprotein‐associated phospholipase A2 activity was associated neither with present nor with incident albuminuria. Lysophosphatidylcholine did not correlate with lipoprotein‐associated phospholipase A2 activity. Cross‐sectional bivariate correlation as well as multivariable linear regression analysis revealed a negative correlation of lipoprotein‐associated phospholipase A2 activity with HbA1c and HDL‐cholesterol. Conclusions: Lipoprotein‐associated phospholipase activity was not associated with surrogate markers for oxidative stress and early diabetic nephropathy. The association of decreased lipoprotein‐associated phospholipase A2 activity with poor glucose control might limit its function as a predictor of micro‐ and macrovascular diseases in Type 1 diabetes. What's new?: High levels of lipoprotein‐associated phospholipase A2 activity have been shown to be strong predictive markers for cardiovascular events and are associated with oxidative stress.In our cohort of adolescents with Type 1 diabetes, lipoprotein‐associated phospholipase A2 was not associated with albuminuria and lysophosphatidylcholine as surrogate markers of diabetic microvascular disease and oxidative stress.By contrast, lipoprotein‐associated phospholipase A2 activity was negatively correlated with HbA1c levels.This negative association of lipoprotein‐associated phospholipase A2 with HbA1c levels may limit its use as a cardiovascular risk marker in people with diabetes. [ABSTRACT FROM AUTHOR]

Published
2020
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47. Incidence and trends of childhood Type 1 diabetes worldwide 1990–1999

Author

THE DIAMOND PROJECT GROUP, BESSAOUD K, BOUDRAA G, DE ROPOLO MM, DE SEREDAY M, MARTI ML, MOSER M, LAPERTOSA S, DAMIANO M, VERGE C, HOWARD N, SCHOBER E, JORDAN O, WEETS I, GORUS F, COECKELBERGHS M, ROOMAN R, VAN GAAL L, FRANCO LJ, FERREIRA SRG, LISBOA HPK, KURTZ LA, GRAEBIN R, KUTZKE L, RODRIGES C, SAVOVA R, CHRISTOV V, IOTOVA V, TZANEVA V, PACAUD D, TOTH E, TAN MH, CARRASCO E, PEREZ F, ZE Y, BO Y, CHEN S, FU L, DENG L, SHEN S, TENG K, WANG C, JIAN H, JU J, YAN C, DENG Y, LI C, ZHANG Y, LIU Y, LONG X, ZHEN Z, SUN Z, WANG B, WONG G, ORREGO OV, ASCHNER P, DIAZ DIAZ O, DE ACOSTA OM, CINEK O, VAVRINEC J, OLSEN BS, SVENDSEN AJ, KREUTZFELDT J, LUND E, TULL ES, SELMAN GEARA A, ALMONTE AS, PODAR T, TUOMILEHTO J, KARVONEN M, NOTKOLA IL, MOLTCHANOVA E, TASKINEN O, LEVY MARCHAL C, CZERNICHOW P, KOCAVA M, NEU A, EHEHALT S, ROSENBAUER J, GIANI G, ICKS A, BARTSOCAS C, VAZEOU A, SOLTESZ G, LARON Z, GORDON O, ALBAG Y, SHAMIS I, PURRELLO F, ARPI M, FICHERA G, MANCUSO M, LUCENTI C, CHIUMELLO G, BRUNO G, PAGANO G, SONGINI M, CASU A, MARINARO A, FRONGIA P, ZEDDA MA, MILIA A, TENCONI MT, POZZILLI P, VISALLI N, SEBASTIANI L, MARIETTI G, BUZZETTI R, CHERUBINI V, OKUNO A, HARADA S, MATSUURA N, MIKI E, MIYAMOTO S, SASAKI N, MIMURA G, SHALTOUT A, QABAZRD M, AL KHAWARI M, BRIGIS G, DZIVITE I, KADIKI O, URBONAITE B, DE BEAUFORT C, GAREEBOO H, RUEDA OA, REESER M, ELLIOTT R, SCOTT R, WILLIS J, DARLOW B, JONER G, RAFIQUE G, JAWAD F, JIMENEZ J, PALACIOS CM, CANETE F, VERA J, ALMIRON R, BENITEZ GE, ESPINOLA CS, SECLEN S, WOZNICKA D, SZYBINSKI Z, PLACZKIEWICZ E, JAROSZ CHOBOT P, MENEZES C, PINA EA, RUAS MMA, RODRIGUES FJC, ABREU S, IONESCU TIRGOVISTE C, SHUBNIKOV E, MICHALKOVA D, BARK L, HLAVA P, MIKULECKY M, KRZISNIK C, BATTELINO T, URSIC NB, KOTNIK P, KO KW, CASTELL C, GODAY A, MAGZOUB M, DAHLQUIST G, SCHOENLE E, NAGATI K, KHALIFA FB, BURDEN A, RAYMOND N, MILLWARD BA, ZHAO H, PATTERSON CC, CARSON D, HADDEN D, SMAIL P, MCSPORRAN B, WAUGH N, BINGLEY P, MCKINNEY PA, FELTBOWER RG, BODANSKY HJ, CAMPBELL F, LAPORTE RE, LIBMAN I, ROSEMAN J, RAHMAN SMA, DE LLADO TF, LIPTON R, JORGE AM, GUNCZLER P, LANES R., DEVOTI, Gabriele, THE DIAMOND PROJECT, Group, Bessaoud, K, Boudraa, G, DE ROPOLO, Mm, DE SEREDAY, M, Marti, Ml, Moser, M, Lapertosa, S, Damiano, M, Verge, C, Howard, N, Schober, E, Jordan, O, Weets, I, Gorus, F, Coeckelberghs, M, Rooman, R, VAN GAAL, L, Franco, Lj, Ferreira, Srg, Lisboa, Hpk, Kurtz, La, Graebin, R, Kutzke, L, Rodriges, C, Savova, R, Christov, V, Iotova, V, Tzaneva, V, Pacaud, D, Toth, E, Tan, Mh, Carrasco, E, Perez, F, Ze, Y, Bo, Y, Chen, S, Fu, L, Deng, L, Shen, S, Teng, K, Wang, C, Jian, H, Ju, J, Yan, C, Deng, Y, Li, C, Zhang, Y, Liu, Y, Long, X, Zhen, Z, Sun, Z, Wang, B, Wong, G, Orrego, Ov, Aschner, P, DIAZ DIAZ, O, DE ACOSTA, Om, Cinek, O, Vavrinec, J, Olsen, B, Svendsen, Aj, Kreutzfeldt, J, Lund, E, Tull, E, SELMAN GEARA, A, Almonte, A, Podar, T, Tuomilehto, J, Karvonen, M, Notkola, Il, Moltchanova, E, Taskinen, O, LEVY MARCHAL, C, Czernichow, P, Kocava, M, Neu, A, Ehehalt, S, Rosenbauer, J, Giani, G, Icks, A, Bartsocas, C, Vazeou, A, Soltesz, G, Laron, Z, Gordon, O, Albag, Y, Shamis, I, Purrello, F, Arpi, M, Fichera, G, Mancuso, M, Lucenti, C, Chiumello, G, Bruno, G, Pagano, G, Songini, M, Casu, A, Marinaro, A, Frongia, P, Zedda, Ma, Milia, A, Tenconi, Mt, Devoti, Gabriele, Pozzilli, P, Visalli, N, Sebastiani, L, Marietti, G, Buzzetti, R, Cherubini, V, Okuno, A, Harada, S, Matsuura, N, Miki, E, Miyamoto, S, Sasaki, N, Mimura, G, Shaltout, A, Qabazrd, M, AL KHAWARI, M, Brigis, G, Dzivite, I, Kadiki, O, Urbonaite, B, DE BEAUFORT, C, Gareeboo, H, Rueda, Oa, Reeser, M, Elliott, R, Scott, R, Willis, J, Darlow, B, Joner, G, Rafique, G, Jawad, F, Jimenez, J, Palacios, Cm, Canete, F, Vera, J, Almiron, R, Benitez, Ge, Espinola, C, Seclen, S, Woznicka, D, Szybinski, Z, Placzkiewicz, E, JAROSZ CHOBOT, P, Menezes, C, Pina, Ea, Ruas, Mma, Rodrigues, Fjc, Abreu, S, IONESCU TIRGOVISTE, C, Shubnikov, E, Michalkova, D, Bark, L, Hlava, P, Mikulecky, M, Krzisnik, C, Battelino, T, Ursic, Nb, Kotnik, P, Ko, Kw, Castell, C, Goday, A, Magzoub, M, Dahlquist, G, Schoenle, E, Nagati, K, Khalifa, Fb, Burden, A, Raymond, N, Millward, Ba, Zhao, H, Patterson, Cc, Carson, D, Hadden, D, Smail, P, Mcsporran, B, Waugh, N, Bingley, P, Mckinney, Pa, Feltbower, Rg, Bodansky, Hj, Campbell, F, Laporte, Re, Libman, I, Roseman, J, Rahman, Sma, DE LLADO, Tf, Lipton, R, Jorge, Am, Gunczler, P, and Lanes, R.

Subjects
Male, Adolescent, type 1 diabetes, Incidence, Endocrinology, Diabetes and Metabolism, Infant, Newborn, Infant, Global Health, World Health Organization, trend, Diabetes Mellitus, Type 1, Endocrinology, Child, Preschool, geographical distribution, incidence, Internal Medicine, Humans, epidemiology, Female, Child
Abstract

Aims. To examine incidence and trends of Type 1 diabetes worldwide for the period 1990–1999. Methods. The incidence of Type 1 diabetes (per 100000/year) was analysed in children aged ≤ 14 years from 114 populations in 112 centres in 57 countries. Trends in the incidence of Type 1 diabetes were analysed by fitting Poisson regression models to the dataset. Results. A total of 43013 cases were diagnosed in the study populations of 84 million children. The age-adjusted incidence of Type 1 diabetes among 112 centres (114 populations) varied from 0.1 per 100000/year in China and Venezuela to 40.9 per 100000/year in Finland. The average annual increase in incidence calculated from 103 centres was 2.8% (95% CI 2.4–3.2%). During the years 1990–1994, this increase was 2.4% (95% CI 1.3–3.4%) and during the second study period of 1995–1999 it was slightly higher at 3.4% (95% CI 2.7– 4.3%). The trends estimated for continents showed statistically significant increases all over the world (4.0% in Asia, 3.2% in Europe and 5.3% in North America), except in Central America and the West Indies where the trend was a decrease of 3.6%. Only among the European populations did the trend in incidence diminish with age. Conclusions. The rising incidence of Type 1 diabetes globally suggests the need for continuous monitoring of incidence by using standardized methods in order to plan or assess prevention strategies.

Published
2006
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48. The impact of area deprivation on treatment and outcome quality of 29,284 pediatric patients with type 1 diabetes in Germany. Results from the German DPV Registry

Author

Auzanneau, M., primary, Lanzinger, S., additional, Kroschwald, P., additional, Kuhnle-Krahl, U., additional, Martin, H.P., additional, Placzek, K., additional, Hamman, J., additional, Bachran, R., additional, Bohn, B., additional, Rosenbauer, J., additional, and Maier, W., additional

Published
2018
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