27,457 results on '"Rosen P"'
Search Results
2. Severe Convection at Burgas Airport: Case Study 17 September 2022
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Bilyana Kostashki, Rosen Penchev, and Guergana Guerova
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severe convection ,GNSS integrated water vapour ,integrated vapour transport ,Science - Abstract
Convection monitoring and forecasting are crucial for air traffic management as they can lead to the development of intense thunderstorms and hazards such as severe turbulence and icing, lightning activity, microbursts and hail that affect aviation safety. The airport of Burgas is located in southeast Bulgaria on the Black Sea coast and occurrences of intense thunderstorms are mainly observed in the warm season between May and September. This work presents an analysis of severe convection over southeast Bulgaria on 17 September 2022. In the late afternoon, a gust front was formed that reached the Burgas airport with a wind speed exceeding 45 m/s, the record for the past 50 years, damaging the instrument landing system of the airport. To analyse the severe weather conditions, we combine state-of-the-art observations from satellite and radar with the upper-air sounding and surface. The studied period was dominated by the presence of a very unstable air mass over southeast Bulgaria ahead of the atmospheric front. As convection developed and moved east towards Burgas, it had four characteristics of severe deep convection, including gravitational waves at the overshooting cloud top, a cold U-shape, a flanking line and a cloud top temperature below −70 °C. The positive integrated water vapour (IWV) rate of change preceded the lightning activity peak by 30 min. Analysis of integrated vapour transport (IVT) gives higher values by a factor of two compared to climatology associated with the atmospheric river covering the eastern Mediterranean sea.
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- 2024
- Full Text
- View/download PDF
3. Seeing Through the Fog: A Cost-Effectiveness Analysis of Hallucination Detection Systems
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Thomas, Alexander, Rosen, Seth, and Vettrivel, Vishnu
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Computer Science - Computation and Language ,Computer Science - Artificial Intelligence ,I.2.7 - Abstract
This paper presents a comparative analysis of hallucination detection systems for AI, focusing on automatic summarization and question answering tasks for Large Language Models (LLMs). We evaluate different hallucination detection systems using the diagnostic odds ratio (DOR) and cost-effectiveness metrics. Our results indicate that although advanced models can perform better they come at a much higher cost. We also demonstrate how an ideal hallucination detection system needs to maintain performance across different model sizes. Our findings highlight the importance of choosing a detection system aligned with specific application needs and resource constraints. Future research will explore hybrid systems and automated identification of underperforming components to enhance AI reliability and efficiency in detecting and mitigating hallucinations., Comment: 18 pags, 13 figures, 2 tables
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- 2024
4. A Multi-Agent Reinforcement Learning Testbed for Cognitive Radio Applications
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Vangaru, Sriniketh, Rosen, Daniel, Green, Dylan, Rodriguez, Raphael, Wiecek, Maxwell, Johnson, Amos, Jones, Alyse M., and Headley, William C.
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Multiagent Systems ,Computer Science - Networking and Internet Architecture - Abstract
Technological trends show that Radio Frequency Reinforcement Learning (RFRL) will play a prominent role in the wireless communication systems of the future. Applications of RFRL range from military communications jamming to enhancing WiFi networks. Before deploying algorithms for these purposes, they must be trained in a simulation environment to ensure adequate performance. For this reason, we previously created the RFRL Gym: a standardized, accessible tool for the development and testing of reinforcement learning (RL) algorithms in the wireless communications space. This environment leveraged the OpenAI Gym framework and featured customizable simulation scenarios within the RF spectrum. However, the RFRL Gym was limited to training a single RL agent per simulation; this is not ideal, as most real-world RF scenarios will contain multiple intelligent agents in cooperative, competitive, or mixed settings, which is a natural consequence of spectrum congestion. Therefore, through integration with Ray RLlib, multi-agent reinforcement learning (MARL) functionality for training and assessment has been added to the RFRL Gym, making it even more of a robust tool for RF spectrum simulation. This paper provides an overview of the updated RFRL Gym environment. In this work, the general framework of the tool is described relative to comparable existing resources, highlighting the significant additions and refactoring we have applied to the Gym. Afterward, results from testing various RF scenarios in the MARL environment and future additions are discussed., Comment: Accepted to IEEE CCNC 2025
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- 2024
5. MAMMAL -- Molecular Aligned Multi-Modal Architecture and Language
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Shoshan, Yoel, Raboh, Moshiko, Ozery-Flato, Michal, Ratner, Vadim, Golts, Alex, Weber, Jeffrey K., Barkan, Ella, Rabinovici-Cohen, Simona, Polaczek, Sagi, Amos, Ido, Shapira, Ben, Hazan, Liam, Ninio, Matan, Ravid, Sivan, Danziger, Michael M., Morrone, Joseph A., Suryanarayanan, Parthasarathy, Rosen-Zvi, Michal, and Hexter, Efrat
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Quantitative Biology - Quantitative Methods ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
Drug discovery typically consists of multiple steps, including identifying a target protein key to a disease's etiology, validating that interacting with this target could prevent symptoms or cure the disease, discovering a small molecule or biologic therapeutic to interact with it, and optimizing the candidate molecule through a complex landscape of required properties. Drug discovery related tasks often involve prediction and generation while considering multiple entities that potentially interact, which poses a challenge for typical AI models. For this purpose we present MAMMAL - Molecular Aligned Multi-Modal Architecture and Language - a method that we applied to create a versatile multi-task multi-align foundation model that learns from large-scale biological datasets (2 billion samples) across diverse modalities, including proteins, small molecules, and genes. We introduce a prompt syntax that supports a wide range of classification, regression, and generation tasks. It allows combining different modalities and entity types as inputs and/or outputs. Our model handles combinations of tokens and scalars and enables the generation of small molecules and proteins, property prediction, and transcriptomic lab test predictions. We evaluated the model on 11 diverse downstream tasks spanning different steps within a typical drug discovery pipeline, where it reaches new SOTA in 9 tasks and is comparable to SOTA in 2 tasks. This performance is achieved while using a unified architecture serving all tasks, in contrast to the original SOTA performance achieved using tailored architectures. The model code and pretrained weights are publicly available at https://github.com/BiomedSciAI/biomed-multi-alignment and https://huggingface.co/ibm/biomed.omics.bl.sm.ma-ted-458m.
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- 2024
6. Crystallization of Binary Nanocrystal Superlattices and the Relevance of Short-Range Attraction
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Marino, Emanuele, LaCour, R. Allen, Moore, Timothy C., van Dongen, Sjoerd W., Keller, Austin W., An, Di, Yang, Shengsong, Rosen, Daniel J., Gouget, Guillaume, Tsai, Esther H. R., Kagan, Cherie R., Kodger, Thomas E., Glotzer, Sharon C., and Murray, Christopher B.
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Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Soft Condensed Matter - Abstract
The synthesis of binary nanocrystal superlattices (BNSLs) enables the targeted integration of orthogonal physical properties, like photoluminescence and magnetism, into a single superstructure, unlocking a vast design space for multifunctional materials. Yet, the formation mechanism of BNSLs remains poorly understood, restricting the use of simulation to predict the structure and properties of the superlattices. Here, we use a combination of in situ scattering and molecular simulation to elucidate the self-assembly of two common BNSLs through emulsion templating. Our self-assembly experiments reveal that no intermediate structures precede the formation of the final binary phases, indicating that their formation proceeds through classical nucleation. Using simulations, we find that, despite the formation of AlB2 and NaZn13 typically being attributed to entropy, their self-assembly is most consistent with the nanocrystals possessing short-range interparticle attraction, which we find can dramatically accelerate nucleation kinetics in BNSLs. We also find homogenous, classical nucleation in simulation, corroborating our experiments. These results establish a robust correspondence between experiment and theory, paving the way towards a priori prediction of BNSLs.
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- 2024
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7. A Trust-Region Method for Graphical Stein Variational Inference
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Pavlovic, Liam and Rosen, David M.
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Computer Science - Machine Learning ,Statistics - Machine Learning - Abstract
Stein variational inference (SVI) is a sample-based approximate Bayesian inference technique that generates a sample set by jointly optimizing the samples' locations to minimize an information-theoretic measure of discrepancy with the target probability distribution. SVI thus provides a fast and significantly more sample-efficient approach to Bayesian inference than traditional (random-sampling-based) alternatives. However, the optimization techniques employed in existing SVI methods struggle to address problems in which the target distribution is high-dimensional, poorly-conditioned, or non-convex, which severely limits the range of their practical applicability. In this paper, we propose a novel trust-region optimization approach for SVI that successfully addresses each of these challenges. Our method builds upon prior work in SVI by leveraging conditional independences in the target distribution (to achieve high-dimensional scaling) and second-order information (to address poor conditioning), while additionally providing an effective adaptive step control procedure, which is essential for ensuring convergence on challenging non-convex optimization problems. Experimental results show our method achieves superior numerical performance, both in convergence rate and sample accuracy, and scales better in high-dimensional distributions, than previous SVI techniques.
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- 2024
8. The High-resolution Accretion Disks of Embedded protoStars (HADES) simulations. I. Impact of Protostellar Magnetic Fields on the Accretion Modes
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Gaches, Brandt A. L., Tan, Jonathan C., Rosen, Anna L., and Kuiper, Rolf
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
How embedded, actively accreting low-mass protostars accrete their mass is still greatly debated. Observations are now piecing together the puzzle of embedded protostellar accretion, in particular with new facilities in the near-infrared. However, high-resolution theoretical models are still lacking, with a stark paucity of detailed simulations of these early phases. Here we present high-resolution non-ideal magneto-hydrodynamic simulations of a Solar mass protostar accreting at rates exceeding 10$^{-6} M_{\odot}$ yr$^{-1}$. We show the results of the accretion flow for four different protostellar magnetic fields, 10 G, 500 G, 1 kG, and 2 kG, combined with a disk magnetic field. For weaker (10 G and 500 G) protostar magnetic fields, accretion occurs via a turbulent boundary layer mode, with disk material impacting across the protostellar surface. In the 500 G model, the presence of a magnetically dominated outflow focuses the accretion towards the equator, slightly enhancing and ordering the accretion. For kG magnetic fields, the disk becomes truncated due to the protostellar dipole and exhibits magnetospheric accretion, with the 2 kG model having accretion bursts induced by the interchange instability. We present bolometric light curves for the models and find that they reproduce observations of Class I protostars from YSOVAR, with high bursts followed by an exponential decay possibly being a signature of instability-driven accretion. Finally, we present the filling fractions of accretion and find that 90\% of the mass is accreted in a surface area fraction of 10-20\%. These simulations will be extended in future work for a broader parameter space, with their high resolution and high temporal spacing able to explore a wide range of interesting protostellar physics., Comment: Accepted to A&A
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- 2024
9. Flat-band (de)localization emulated with a superconducting qubit array
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Rosen, Ilan T., Muschinske, Sarah, Barrett, Cora N., Rower, David A., Das, Rabindra, Kim, David K., Niedzielski, Bethany M., Schuldt, Meghan, Serniak, Kyle, Schwartz, Mollie E., Yoder, Jonilyn L., Grover, Jeffrey A., and Oliver, William D.
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Condensed Matter - Mesoscale and Nanoscale Physics ,Quantum Physics - Abstract
Arrays of coupled superconducting qubits are analog quantum simulators able to emulate a wide range of tight-binding models in parameter regimes that are difficult to access or adjust in natural materials. In this work, we use a superconducting qubit array to emulate a tight-binding model on the rhombic lattice, which features flat bands. Enabled by broad adjustability of the dispersion of the energy bands and of on-site disorder, we examine regimes where flat-band localization and Anderson localization compete. We observe disorder-induced localization for dispersive bands and disorder-induced delocalization for flat bands. Remarkably, we find a sudden transition between the two regimes and, in its vicinity, the semblance of quantum critical scaling., Comment: 8 pages, 5 figures, and Supplementary Information
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- 2024
10. A Survey on Annotations in Information Visualization: Empirical Insights, Applications, and Challenges
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Rahman, Md Dilshadur, Doppalapudi, Bhavana, Quadri, Ghulam Jilani, and Rosen, Paul
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Computer Science - Human-Computer Interaction - Abstract
We present a comprehensive survey on the use of annotations in information visualizations, highlighting their crucial role in improving audience understanding and engagement with visual data. Our investigation encompasses empirical studies on annotations, showcasing their impact on user engagement, interaction, comprehension, and memorability across various contexts. We also study the existing tools and techniques for creating annotations and their diverse applications, enhancing the understanding of both practical and theoretical aspects of annotations in data visualization. Additionally, we identify existing research gaps and propose potential future research directions, making our survey a valuable resource for researchers, visualization designers, and practitioners by providing a thorough understanding of the application of annotations in visualization.
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- 2024
11. An Overview of the Burer-Monteiro Method for Certifiable Robot Perception
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Papalia, Alan, Tian, Yulun, Rosen, David M., How, Jonathan P., and Leonard, John J.
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Computer Science - Robotics ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning ,49, 68 ,I.4.0 ,I.5.0 ,J.2 - Abstract
This paper presents an overview of the Burer-Monteiro method (BM), a technique that has been applied to solve robot perception problems to certifiable optimality in real-time. BM is often used to solve semidefinite programming relaxations, which can be used to perform global optimization for non-convex perception problems. Specifically, BM leverages the low-rank structure of typical semidefinite programs to dramatically reduce the computational cost of performing optimization. This paper discusses BM in certifiable perception, with three main objectives: (i) to consolidate information from the literature into a unified presentation, (ii) to elucidate the role of the linear independence constraint qualification (LICQ), a concept not yet well-covered in certifiable perception literature, and (iii) to share practical considerations that are discussed among practitioners but not thoroughly covered in the literature. Our general aim is to offer a practical primer for applying BM towards certifiable perception., Comment: Accepted to 2024 Robotics: Science and Systems (RSS) Safe Autonomy Workshop
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- 2024
12. Low-degree Security of the Planted Random Subgraph Problem
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Bogdanov, Andrej, Jones, Chris, Rosen, Alon, and Zadik, Ilias
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Computer Science - Cryptography and Security ,Computer Science - Data Structures and Algorithms ,Mathematics - Statistics Theory - Abstract
The planted random subgraph detection conjecture of Abram et al. (TCC 2023) asserts the pseudorandomness of a pair of graphs $(H, G)$, where $G$ is an Erdos-Renyi random graph on $n$ vertices, and $H$ is a random induced subgraph of $G$ on $k$ vertices. Assuming the hardness of distinguishing these two distributions (with two leaked vertices), Abram et al. construct communication-efficient, computationally secure (1) 2-party private simultaneous messages (PSM) and (2) secret sharing for forbidden graph structures. We prove the low-degree hardness of detecting planted random subgraphs all the way up to $k\leq n^{1 - \Omega(1)}$. This improves over Abram et al.'s analysis for $k \leq n^{1/2 - \Omega(1)}$. The hardness extends to $r$-uniform hypergraphs for constant $r$. Our analysis is tight in the distinguisher's degree, its advantage, and in the number of leaked vertices. Extending the constructions of Abram et al, we apply the conjecture towards (1) communication-optimal multiparty PSM protocols for random functions and (2) bit secret sharing with share size $(1 + \epsilon)\log n$ for any $\epsilon > 0$ in which arbitrary minimal coalitions of up to $r$ parties can reconstruct and secrecy holds against all unqualified subsets of up to $\ell = o(\epsilon \log n)^{1/(r-1)}$ parties.
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- 2024
13. Seeing is Believing: The Role of Scatterplots in Recommender System Trust and Decision-Making
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Doppalapudi, Bhavana, Rahman, Md Dilshadur, and Rosen, Paul
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Computer Science - Human-Computer Interaction - Abstract
The accuracy of recommender systems influences their trust and decision-making when using them. Providing additional information, such as visualizations, offers context that would otherwise be lacking. However, the role of visualizations in influencing trust and decisions with recommender systems is under-explored. To bridge this gap, we conducted a two-part human-subject experiment to investigate the impact of scatterplots on recommender system decisions. Our first study focuses on high-level decisions, such as selecting which recommender system to use. The second study focuses on low-level decisions, such as agreeing or disagreeing with a specific recommendation. Our results show scatterplots accompanied by higher levels of accuracy influence decisions and that participants tended to trust the recommendations more when scatterplots were accompanied by descriptive accuracy (e.g., \textit{high}, \textit{medium}, or \textit{low}) instead of numeric accuracy (e.g., \textit{90\%}). Furthermore, we observed scatterplots often assisted participants in validating their decisions. Based on the results, we believe that scatterplots and visualizations, in general, can aid in making informed decisions, validating decisions, and building trust in recommendation systems.
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- 2024
14. Qubit-State Purity Oscillations from Anisotropic Transverse Noise
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Rower, David A., Hida, Kotaro, Ateshian, Lamia, Zhang, Helin, An, Junyoung, Hays, Max, Muschinske, Sarah E., McNally, Christopher M., Alipour-Fard, Samuel C., Assouly, Réouven, Rosen, Ilan T., Niedzielski, Bethany M., Schwartz, Mollie E., Serniak, Kyle, Grover, Jeffrey A., and Oliver, William D.
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Quantum Physics - Abstract
We explore the dynamics of qubit-state purity in the presence of transverse noise that is anisotropically distributed in the Bloch-sphere XY plane. We perform Ramsey experiments with noise injected along a fixed laboratory-frame axis and observe oscillations in the purity at twice the qubit frequency arising from the intrinsic qubit Larmor precession. We probe the oscillation dependence on the noise anisotropy, orientation, and power spectral density, using a low-frequency fluxonium qubit. Our results elucidate the impact of transverse noise anisotropy on qubit decoherence and may be useful to disentangle charge and flux noise in superconducting quantum circuits.
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- 2024
15. Mutual neutralization of C$_{60}^+$ and C$_{60}^-$ ions: Excitation energies and state-selective rate coefficients
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Gatchell, Michael, Paul, Raka, Ji, MingChao, Rosén, Stefan, Thomas, Richard D., Cederquist, Henrik, Schmidt, Henning T., Larson, Åsa, and Zettergren, Henning
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Astrophysics - Astrophysics of Galaxies ,Physics - Chemical Physics - Abstract
Context: Mutual neutralization between cations and anions play an important role in determining the charge-balance in certain astrophysical environments. However, empirical data for such reactions involving complex molecular species has been lacking due to challenges in performing experimental studies, leaving the astronomical community to rely on decades old models with large uncertainties for describing these processes in the interstellar medium. Aims: To investigate the mutual neutralization (MN) reaction, C$_{60}^+$ + C$_{60}^-$ $\rightarrow$ C$_{60}^*$ + C$_{60}$, for collisions at interstellar-like conditions. Methods: The mutual neutralization reaction between C$_{60}^+$ and C$_{60}^-$ at collision energies of 100\,meV was studied using the Double ElectroStatic Ion Ring ExpEriment, DESIREE, and its merged-beam capabilities. To aid in the interpretation of the experimental results, semi-classical modeling based on the Landau-Zener approach was performed for the studied reaction. Results: We experimentally identify a narrow range of kinetic energies for the neutral reaction products. Modeling was used to calculate the quantum state-selective reaction probabilities, absolute cross sections, and rate coefficients of these MN reactions, using the experimental results as a benchmark. The MN cross sections are compared with model results for electron attachment to C$_{60}$ and electron recombination with C$_{60}^+$. Conclusions: The present results show that it is crucial to take mutual polarization effects, the finite sizes, and the final quantum states of both molecular ions into account for reliable predictions of MN rates expected to strongly influence the charge-balance and chemistry in, e.g., dense molecular clouds., Comment: 9 pages, 4 figures
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- 2024
16. How to Build the Virtual Cell with Artificial Intelligence: Priorities and Opportunities
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Bunne, Charlotte, Roohani, Yusuf, Rosen, Yanay, Gupta, Ankit, Zhang, Xikun, Roed, Marcel, Alexandrov, Theo, AlQuraishi, Mohammed, Brennan, Patricia, Burkhardt, Daniel B., Califano, Andrea, Cool, Jonah, Dernburg, Abby F., Ewing, Kirsty, Fox, Emily B., Haury, Matthias, Herr, Amy E., Horvitz, Eric, Hsu, Patrick D., Jain, Viren, Johnson, Gregory R., Kalil, Thomas, Kelley, David R., Kelley, Shana O., Kreshuk, Anna, Mitchison, Tim, Otte, Stephani, Shendure, Jay, Sofroniew, Nicholas J., Theis, Fabian, Theodoris, Christina V., Upadhyayula, Srigokul, Valer, Marc, Wang, Bo, Xing, Eric, Yeung-Levy, Serena, Zitnik, Marinka, Karaletsos, Theofanis, Regev, Aviv, Lundberg, Emma, Leskovec, Jure, and Quake, Stephen R.
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Quantitative Biology - Quantitative Methods ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning ,Quantitative Biology - Neurons and Cognition - Abstract
The cell is arguably the most fundamental unit of life and is central to understanding biology. Accurate modeling of cells is important for this understanding as well as for determining the root causes of disease. Recent advances in artificial intelligence (AI), combined with the ability to generate large-scale experimental data, present novel opportunities to model cells. Here we propose a vision of leveraging advances in AI to construct virtual cells, high-fidelity simulations of cells and cellular systems under different conditions that are directly learned from biological data across measurements and scales. We discuss desired capabilities of such AI Virtual Cells, including generating universal representations of biological entities across scales, and facilitating interpretable in silico experiments to predict and understand their behavior using virtual instruments. We further address the challenges, opportunities and requirements to realize this vision including data needs, evaluation strategies, and community standards and engagement to ensure biological accuracy and broad utility. We envision a future where AI Virtual Cells help identify new drug targets, predict cellular responses to perturbations, as well as scale hypothesis exploration. With open science collaborations across the biomedical ecosystem that includes academia, philanthropy, and the biopharma and AI industries, a comprehensive predictive understanding of cell mechanisms and interactions has come into reach.
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- 2024
17. Remote Entangling Gates for Spin Qubits in Quantum Dots using an Offset-Charge-Sensitive Transmon Coupler
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Kang, Harry Hanlim, Rosen, Ilan T., Hays, Max, Grover, Jeffrey A., and Oliver, William D.
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Quantum Physics ,Condensed Matter - Mesoscale and Nanoscale Physics ,Physics - Applied Physics - Abstract
We propose a method to realize microwave-activated CZ gates between two remote spin qubits in quantum dots using an offset-charge-sensitive transmon coupler. The qubits are longitudinally coupled to the coupler, so that the transition frequency of the coupler depends on the logical qubit states; a capacitive network model using first-quantized charge operators is developed to illustrate this. Driving the coupler transition then implements a conditional phase shift on the qubits. Two pulsing schemes are investigated: a rapid, off-resonant pulse with constant amplitude, and a pulse with envelope engineering that incorporates dynamical decoupling to mitigate charge noise. We develop non-Markovian time-domain simulations to accurately model gate performance in the presence of $1/f^\beta$ charge noise. Simulation results indicate that a CZ gate fidelity exceeding 90% is possible with realistic parameters and noise models., Comment: 19 pages, 8 figures
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- 2024
18. Moduli of continuity for the local times of rebirthed Markov processes
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Fitzsimmons, P. J., Marcus, Michael B., and Rosen, Jay
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Mathematics - Probability ,60G15, 60G17, 60J40, 60J55, 60J60 - Abstract
Let $S$ a be locally compact space with a countable base. Let $\cal Y$ be a transient symmetric Borel right process with state space $S$ and continuous strictly positive $p$--potential densities $u^p(x,y)$. Local and uniform moduli of continuity are obtained for the local times of both fully and partially rebirthed versions of $\cal Y$. A fully rebirthed version of $\cal Y$ is an extension of $\cal Y$ so that instead of terminating at the end of its lifetime it is immediately ``reborn'' with a probability measure $\mu $, on $S$. I.e., the process goes to the set $B\subset S$ with probability $\mu(B) $, after which it continues to evolve the way $\YY$ did, being reborn with probability $\mu $ each time it dies. This rebirthed version of $\cal Y$ is a recurrent Borel right process with state space $S$ and $p$-potential densities of form, \[ u^p(x,y)+h(x,y),\qquad x,y\in S,\,\, p>0, \] where $h(x,y)$ is not symmetric. The local times of the rebirthed process are given in terms of the local times of $\cal Y$ and isomorphism theorems in the spirit of Dynkin, Eisenbam and Kaspi are obtained that relate these local times to generalized chi--square processes formed by Gaussian processes with covariances $u^{q}(x,y)$ for different values of $q$. These isomorphisms allow one to obtain exact local and uniform moduli of continuity for the local times of the rebirthed process. Several explicit examples are given in which $\cal Y$ is either a modified L\'evy process or a diffusion. Analogous results are obtained for partially rebirthed versions of $\cal Y$. This is obtained by starting $\cal Y$ in $S$ and when it dies returning it to $S$ with a sub-probability measure $\Xi$. (With probability $1-|\Xi |$ it is sent to a disjoint state space $S'$, where it remains.)
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- 2024
19. A Call to Serve: Novice Urban Catholic School Teachers' Sense of Purpose in Life, Compassion, Faith, and Justice
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Ella Anghel, Kierstin M. Giunco, Audrey A. Friedman, Myra Rosen-Reynoso, Charles T. Cownie III, and Cristina J. Hunter
- Abstract
Educators are instrumental in nurturing students' sense of purpose, particularly in urban schools. Consequently, these educators must not only have a strong sense of purpose but also possess other key virtues. This mixed-methods study explores these virtues among a group of 30 urban Catholic school teachers. They responded to scales measuring purpose, compassion, faith, moral development and agency, and completed a modified Youth Purpose Interview online. Scores were compared to those of the original samples upon which these scales were validated as they were also emerging adults. Participants scored significantly higher on almost all scales than the original samples. These quantitative results and interview data revealed unique sources of purpose such as altruism and compassion towards high-need students. Overall, the participants are strongly disposed to fostering a sense of purpose among their students and respecting the dignity and worth of all persons.
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- 2024
20. A Longitudinal Mixed-Methods Characterization of Family Support from Adolescence to Young Adulthood in Autism and Other Developmental Disabilities
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Hillary K. Schiltz, Elaine Clarke, Nicole Rosen, Sofi Gomez De La Rosa, Nina Masjedi, Kourtney Christopher, and Catherine Lord
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Although caregiving responsibilities and need for support persist and evolve across the life course in families with autistic youth or youth with other developmental disabilities (DDs), little is known about support during their child's adulthood years. Therefore, the present study used a mixed-methods approach to examine change and stability in formal and informal family support across the transition to adulthood. Caregivers of 126 individuals with autism or DDs completed a modified version of the Family Support Scale, including open-ended questions, at five time points from adolescence (age 16) into young adulthood (age 22). Caregivers reported that informal support from family members was the most frequently used, helpful, and valued source of support with relative stability across time. In contrast, the reported helpfulness, use, and value of formal support (e.g., professionals, schools) for caregivers declined over time. Qualitative content analyses revealed characteristics of highly valued support included support type (e.g., instrumental or emotional) and features of the support source (e.g., their understanding). There was a shift to valuing emotional support more than instrumental support over time, especially for caregivers of less able adults. Partnership and dependability emerged as highly valued features of the support source. These findings fit within a social convoy perspective and likely reflect the "service cliff" experienced by autistic individuals or people with DDs and their families. As social networks shrink over time and formal services are less readily available in adulthood, remaining sources of support, particularly from family members, become increasingly important.
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- 2024
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21. Exploring Methods for Tracking Students' Performance through Curriculum Embedded Assessments Designed to Inform and Accelerate Learning
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BrainPOP, Melissa Hogan, Yigal Rosen, Ilia Rushkin, Barbara Hubert, Maneeza Dawood, and Sara Bakken
- Abstract
This paper explores new methods for tracking learning growth using curriculum-embedded assessments. The key objective of the study was to examine new ways to capture students' performance data to help make ecologically-valid inferences about what learners know and can do long before benchmark or end-of-year assessments. Student learning outcomes are examined through the use of embedded assessments and learning growth mapping. A study of 450,934 students finds that continuous engagement with essential skills on an educational technology platform, BrainPOP, is strongly associated with statistically significant increases in learning gains in Literacy/English Language Arts, Math and Science. Educators might consider using embedded assessments to gain access to and provide early feedback for students. By identifying gaps in students' knowledge, teachers can offer timely support to their most vulnerable students.
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- 2023
22. Virtually Constrained Admittance Control using Feedback Linearization for Physical Human-Robot Interaction with Rehabilitation Exoskeletons
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Sun, Jianwei, Foroutani, Yasamin, and Rosen, Jacob
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Physical human-robot interaction (pHRI) ,admittance control ,feedback linearization ,holonomic constraints ,rehabilitation exoskeletons - Abstract
Robot-assisted rehabilitation focuses in part on path-based assist-as-needed reaching rehabilitation, which dynamically adapts the level of robot assistance during physical therapy to ensure patient progress along a predefined trajectory without over-reliance on the system. Additionally, bimanual exoskeletons have enabled asymmetric rehabilitation schemes, which leverage the patient’s healthy side to guide the rehabilitation through interactions with objects in virtual reality that replicate activities of daily living. Within the context of physical human-robot interaction, these tasks can be formulated as constraints on the space of allowable motions. This study introduces a novel feedback linearization-inspired time-invariant admittance control scheme that enforces these motion constraints by isolating and stabilizing the component of the virtual dynamics transversal to the constraint. The methodology is applied to two rehabilitation tasks: (1) a path-guided reaching task with restoring force field, and (2) a bimanual interaction with a virtual object. Each task is then evaluated on one of two drastically different exoskeleton systems: (1) the V-Rex, a nonanthropomorphic full-body haptic device, and (2) the EXO-UL8, an anthropomorphic bimanual upper-limb exoskeleton. The two systems exist on opposite ends of the task/joint space control, non-redundant/redundant, off-the-shelf (industrial)/custom, nonanthropomorphic/anthropomorphic spectra. Experimental results validate and support the methodology as a generalizable approach to enabling constrained admittance control for rehabilitation robots.
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- 2024
23. Gene-Specific Effects on Brain Volume and Cognition of TMEM106B in Frontotemporal Lobar Degeneration.
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Vandebergh, Marijne, Ramos, Eliana, Corriveau-Lecavalier, Nick, Ramanan, Vijay, Kornak, John, Mester, Carly, Kolander, Tyler, Brushaber, Danielle, Staffaroni, Adam, Geschwind, Daniel, Wolf, Amy, Kantarci, Kejal, Gendron, Tania, Petrucelli, Leonard, Van den Broeck, Marleen, Wynants, Sarah, Baker, Matthew, Borrego-Écija, Sergi, Appleby, Brian, Barmada, Sami, Bozoki, Andrea, Clark, David, Darby, R, Dickerson, Bradford, Domoto-Reilly, Kimiko, Fields, Julie, Galasko, Douglas, Ghoshal, Nupur, Graff-Radford, Neill, Grant, Ian, Honig, Lawrence, Hsiung, Ging-Yuek, Huey, Edward, Irwin, David, Knopman, David, Kwan, Justin, Léger, Gabriel, Litvan, Irene, Masdeu, Joseph, Mendez, Mario, Onyike, Chiadi, Pascual, Belen, Pressman, Peter, Ritter, Aaron, Roberson, Erik, Snyder, Allison, Sullivan, Anna, Tartaglia, Maria, Wint, Dylan, Heuer, Hilary, Forsberg, Leah, Boxer, Adam, Rosen, Howard, Boeve, Bradley, and Rademakers, Rosa
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Humans ,Female ,Male ,Membrane Proteins ,Middle Aged ,Frontotemporal Lobar Degeneration ,Aged ,Nerve Tissue Proteins ,Brain ,Polymorphism ,Single Nucleotide ,Gray Matter ,Cognition ,Organ Size ,Cross-Sectional Studies ,Longitudinal Studies ,Magnetic Resonance Imaging - Abstract
BACKGROUND AND OBJECTIVES: TMEM106B has been proposed as a modifier of disease risk in FTLD-TDP, particularly in GRN pathogenic variant carriers. Furthermore, TMEM106B has been investigated as a disease modifier in the context of healthy aging and across multiple neurodegenerative diseases. The objective of this study was to evaluate and compare the effect of TMEM106B on gray matter volume and cognition in each of the common genetic FTD groups and in patients with sporadic FTD. METHODS: Participants were enrolled through the ARTFL/LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) study, which includes symptomatic and presymptomatic individuals with a pathogenic variant in C9orf72, GRN, MAPT, VCP, TBK1, TARDBP, symptomatic nonpathogenic variant carriers, and noncarrier family controls. All participants were genotyped for the TMEM106B rs1990622 SNP. Cross-sectionally, linear mixed-effects models were fitted to assess an association between TMEM106B and genetic group interaction with each outcome measure (gray matter volume and UDS3-EF for cognition), adjusting for education, age, sex, and CDR+NACC-FTLD sum of boxes. Subsequently, associations between TMEM106B and each outcome measure were investigated within the genetic group. For longitudinal modeling, linear mixed-effects models with time by TMEM106B predictor interactions were fitted. RESULTS: The minor allele of TMEM106B rs1990622, linked to a decreased risk of FTD, associated with greater gray matter volume in GRN pathogenic variant carriers under the recessive dosage model (N = 82, beta = 3.25, 95% CI [0.37-6.19], p = 0.034). This was most pronounced in the thalamus in the left hemisphere (beta = 0.03, 95% CI [0.01-0.06], p = 0.006), with a retained association when considering presymptomatic GRN pathogenic variant carriers only (N = 42, beta = 0.03, 95% CI [0.01-0.05], p = 0.003). The minor allele of TMEM106B rs1990622 also associated with greater cognitive scores among all C9orf72 pathogenic variant carriers (N = 229, beta = 0.36, 95% CI [0.05-0.066], p = 0.021) and in presymptomatic C9orf72 pathogenic variant carriers (N = 106, beta = 0.33, 95% CI [0.03-0.63], p = 0.036), under the recessive dosage model. DISCUSSION: We identified associations of TMEM106B with gray matter volume and cognition in the presence of GRN and C9orf72 pathogenic variants. The association of TMEM106B with outcomes of interest in presymptomatic GRN and C9orf72 pathogenic variant carriers could additionally reflect TMEM106Bs effect on divergent pathophysiologic changes before the appearance of clinical symptoms.
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- 2024
24. Structural neuroanatomy of human facial behaviors.
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Noohi, Fate, Kosik, Eena, Veziris, Christina, Perry, David, Rosen, Howard, Kramer, Joel, Miller, Bruce, Holley, Sarah, Seeley, William, and Sturm, Virginia
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cingulate cortex ,emotion ,facial behavior ,primary motor cortex ,supplementary motor area ,Humans ,Female ,Male ,Aged ,Magnetic Resonance Imaging ,Facial Expression ,Emotions ,Gray Matter ,Middle Aged ,Brain ,Photic Stimulation ,Face ,Image Processing ,Computer-Assisted ,Brain Mapping ,Aged ,80 and over - Abstract
The human face plays a central role in emotions and social communication. The emotional and somatic motor networks generate facial behaviors, but whether facial behaviors have representations in the structural anatomy of the human brain is unknown. We coded 16 facial behaviors in 55 healthy older adults who viewed five videos that elicited emotions and examined whether individual differences in facial behavior were related to regional variation in gray matter volume. Voxel-based morphometry analyses revealed that greater emotional facial behavior during the disgust trial (i.e. greater brow furrowing and eye tightening as well as nose wrinkling and upper lip raising) and the amusement trial (i.e. greater smiling and eye tightening) was associated with larger gray matter volume in midcingulate cortex, supplementary motor area, and precentral gyrus, areas spanning both the emotional and somatic motor networks. When measured across trials, however, these facial behaviors (and others) only related to gray matter volume in the precentral gyrus, a somatic motor network hub. These findings suggest that the emotional and somatic motor networks store structural representations of facial behavior and that the midcingulate cortex is critical for generating the predictable movements in the face that arise during emotions.
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- 2024
25. Analytical ab initio hessian from a deep learning potential for transition state optimization.
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Yuan, Eric, Kumar, Anup, Guan, Xingyi, Hermes, Eric, Rosen, Andrew, Zádor, Judit, Head-Gordon, Teresa, and Blau, Samuel
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Identifying transition states-saddle points on the potential energy surface connecting reactant and product minima-is central to predicting kinetic barriers and understanding chemical reaction mechanisms. In this work, we train a fully differentiable equivariant neural network potential, NewtonNet, on thousands of organic reactions and derive the analytical Hessians. By reducing the computational cost by several orders of magnitude relative to the density functional theory (DFT) ab initio source, we can afford to use the learned Hessians at every step for the saddle point optimizations. We show that the full machine learned (ML) Hessian robustly finds the transition states of 240 unseen organic reactions, even when the quality of the initial guess structures are degraded, while reducing the number of optimization steps to convergence by 2-3× compared to the quasi-Newton DFT and ML methods. All data generation, NewtonNet model, and ML transition state finding methods are available in an automated workflow.
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- 2024
26. Better cardiovascular health is associated with slowed clinical progression in autosomal dominant frontotemporal lobar degeneration variant carriers
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VandeBunte, Anna M, Lee, Hyunwoo, Paolillo, Emily W, Hsiung, Ging‐Yuek Robin, Staffaroni, Adam M, Saloner, Rowan, Tartaglia, Carmela, Yaffe, Kristine, Knopman, David S, Ramos, Eliana Marisa, Rascovsky, Katya, Bozoki, Andrea C, Wong, Bonnie, Domoto‐Reilly, Kimiko, Snyder, Allison, Pressman, Peter, Mendez, Mario F, Litvan, Irene, Fields, Julie A, Galasko, Douglas R, Darby, Ryan, Masdeu, Joseph C, Pasqual, Maria Belen, Honig, Lawrence S, Ghoshal, Nupur, Appleby, Brian S, Mackenzie, Ian R, Heuer, Hilary W, Kramer, Joel H, Boxer, Adam L, Forsberg, Leah K, Boeve, Brad, Rosen, Howard J, Casaletto, Kaitlin B, and Consortium, the ALLFTD
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Biological Psychology ,Biomedical and Clinical Sciences ,Psychology ,Cardiovascular ,Neurosciences ,Clinical Research ,Behavioral and Social Science ,Frontotemporal Dementia (FTD) ,Alzheimer's Disease Related Dementias (ADRD) ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Alzheimer's Disease ,Dementia ,Genetics ,Aging ,Brain Disorders ,Basic Behavioral and Social Science ,Neurodegenerative ,Prevention ,Acquired Cognitive Impairment ,2.1 Biological and endogenous factors ,Neurological ,Good Health and Well Being ,Humans ,Male ,Female ,Frontotemporal Lobar Degeneration ,Middle Aged ,Disease Progression ,Neuropsychological Tests ,Magnetic Resonance Imaging ,White Matter ,Heterozygote ,Aged ,Cognitive Dysfunction ,Brain ,Neuroimaging ,aging ,cardiovascular health ,frontotemporal dementia ,genetic dementia ,Life's Simple 7 ,lifestyle behaviors ,modifiable risk ,neuropsychology ,ALLFTD Consortium ,Clinical Sciences ,Geriatrics ,Clinical sciences ,Biological psychology - Abstract
IntroductionCardiovascular health is important for brain aging, yet its role in the clinical manifestation of autosomal dominant or atypical forms of dementia has not been fully elucidated. We examined relationships between Life's Simple 7 (LS7) and clinical trajectories in individuals with autosomal dominant frontotemporal lobar degeneration (FTLD).MethodsTwo hundred forty-seven adults carrying FTLD pathogenic genetic variants (53% asymptomatic) and 189 non-carrier controls completed baseline LS7, and longitudinal neuroimaging and neuropsychological testing.ResultsAmong variant carriers, higher baseline LS7 is associated with slower accumulation of frontal white matter hyperintensities (WMHs), as well as slower memory and language declines. Higher baseline LS7 associated with larger baseline frontotemporal volume, but not frontotemporal volume trajectories.DiscussionBetter baseline cardiovascular health related to slower cognitive decline and accumulation of frontal WMHs in autosomal dominant FTLD. Optimizing cardiovascular health may be an important modifiable approach to bolster cognitive health and brain integrity in FTLD.HighlightsBetter cardiovascular health associates with slower cognitive decline in frontotemporal lobar degeneration (FTLD). Lifestyle relates to the accumulation of frontal white matter hyperintensities in FTLD. More optimal cardiovascular health associates with greater baseline frontotemporal lobe volume. Optimized cardiovascular health relates to more favorable outcomes in genetic dementia.
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- 2024
27. Frontotemporal lobar degeneration targets brain regions linked to expression of recently evolved genes
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Pasquini, Lorenzo, Pereira, Felipe L, Seddighi, Sahba, Zeng, Yi, Wei, Yongbin, Illán-Gala, Ignacio, Vatsavayai, Sarat C, Friedberg, Adit, Lee, Alex J, Brown, Jesse A, Spina, Salvatore, Grinberg, Lea T, Sirkis, Daniel W, Bonham, Luke W, Yokoyama, Jennifer S, Boxer, Adam L, Kramer, Joel H, Rosen, Howard J, Humphrey, Jack, Gitler, Aaron D, Miller, Bruce L, Pollard, Katherine S, Ward, Michael E, and Seeley, William W
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Biological Psychology ,Psychology ,Acquired Cognitive Impairment ,Neurodegenerative ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Genetics ,Brain Disorders ,Rare Diseases ,Alzheimer's Disease Related Dementias (ADRD) ,Frontotemporal Dementia (FTD) ,Alzheimer's Disease ,Dementia ,Aging ,Neurosciences ,2.1 Biological and endogenous factors ,Neurological ,Humans ,Frontotemporal Lobar Degeneration ,Brain ,Male ,Female ,Aged ,DNA-Binding Proteins ,Middle Aged ,tau Proteins ,Atrophy ,Animals ,Evolution ,Molecular ,Gene Expression ,frontotemporal lobar degeneration ,cryptic exon ,human accelerated regions ,TDP-43 ,tau ,gene expression ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Neurology & Neurosurgery ,Biomedical and clinical sciences ,Health sciences - Abstract
In frontotemporal lobar degeneration (FTLD), pathological protein aggregation in specific brain regions is associated with declines in human-specialized social-emotional and language functions. In most patients, disease protein aggregates contain either TDP-43 (FTLD-TDP) or tau (FTLD-tau). Here, we explored whether FTLD-associated regional degeneration patterns relate to regional gene expression of human accelerated regions (HARs), conserved sequences that have undergone positive selection during recent human evolution. To this end, we used structural neuroimaging from patients with FTLD and human brain regional transcriptomic data from controls to identify genes expressed in FTLD-targeted brain regions. We then integrated primate comparative genomic data to test our hypothesis that FTLD targets brain regions linked to expression levels of recently evolved genes. In addition, we asked whether genes whose expression correlates with FTLD atrophy are enriched for genes that undergo cryptic splicing when TDP-43 function is impaired. We found that FTLD-TDP and FTLD-tau subtypes target brain regions with overlapping and distinct gene expression correlates, highlighting many genes linked to neuromodulatory functions. FTLD atrophy-correlated genes were strongly enriched for HARs. Atrophy-correlated genes in FTLD-TDP showed greater overlap with TDP-43 cryptic splicing genes and genes with more numerous TDP-43 binding sites compared with atrophy-correlated genes in FTLD-tau. Cryptic splicing genes were enriched for HAR genes, and vice versa, but this effect was due to the confounding influence of gene length. Analyses performed at the individual-patient level revealed that the expression of HAR genes and cryptically spliced genes within putative regions of disease onset differed across FTLD-TDP subtypes. Overall, our findings suggest that FTLD targets brain regions that have undergone recent evolutionary specialization and provide intriguing potential leads regarding the transcriptomic basis for selective vulnerability in distinct FTLD molecular-anatomical subtypes.
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- 2024
28. PF-06952229, a selective TGF-β-R1 inhibitor: preclinical development and a first-in-human, phase I, dose-escalation study in advanced solid tumors.
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Yap, T, Choudhury, A, Hamilton, E, Rosen, L, Stratton, K, Gordon, M, Schaer, D, Liu, L, Zhang, L, Mittapalli, R, Zhong, W, Soman, N, and Tolcher, A
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TGF-β signaling ,TGF-β-R1 inhibitor ,advanced solid tumors ,epithelial–mesenchymal transition ,metastatic castration-resistant prostate cancer ,Humans ,Male ,Middle Aged ,Aged ,Receptor ,Transforming Growth Factor-beta Type I ,Female ,Neoplasms ,Animals ,Adult ,Mice ,Antineoplastic Agents ,Dose-Response Relationship ,Drug ,Aged ,80 and over - Abstract
BACKGROUND: PF-06952229 is a selective small-molecule inhibitor of transforming growth factor-β (TGF-β) receptor 1. We evaluated its antitumor activity in preclinical studies and its safety, tolerability, pharmacokinetics, and pharmacodynamics in a phase I study (NCT03685591). PATIENTS AND METHODS: In vitro and in vivo preclinical studies were conducted. Patients (aged ≥18 years) received PF-06952229 monotherapy [20-500 mg, oral b.i.d., 7 days on/7 days off, 28-day cycles, Part 1A (P1A)] for advanced/metastatic solid tumors and combination therapy [250/375 mg with enzalutamide, Part 1B (P1B)] for metastatic castration-resistant prostate cancer (mCRPC). Primary endpoints were dose-limiting toxicity (DLT), adverse events (AEs), and laboratory abnormalities. Efficacy, pharmacokinetic parameters, and biomarker modulation were assessed. RESULTS: PF-06952229 showed activity in preclinical murine tumor models including pSMAD2 modulation in tumors. The study (NCT03685591) enrolled 49 patients (P1A, n = 42; P1B, n = 7). DLTs were reported in 3/35 (8.6%) P1A patients receiving PF-06952229 375 mg (anemia, intracranial tumor hemorrhage, and anemia and hypertension, all grade 3, n = 1 each). The most frequent grade 3 treatment-related AEs (TRAEs) were alanine aminotransferase increased and anemia (9.5% each). There were no grade 4-5 TRAEs. Plasma PF-06952229 exposures were dose proportional between 80 and 375 mg. Pharmacodynamic studies confirmed target modulation of pSMAD2/3 (peripheral monocytes). One P1A patient with prostate cancer receiving PF-06952229 375 mg monotherapy achieved confirmed partial response (31-month duration of response). A total of 8 patients (P1A, n = 6; P1B, n = 2) achieved stable disease. CONCLUSIONS: Antitumor activity of PF-06952229 was observed in preclinical studies. PF-06952229 was generally well tolerated with manageable toxicity; a small group of patients achieved durable responses and/or disease stabilization.
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- 2024
29. A Longitudinal Mixed-Methods Characterization of Family Support from Adolescence to Young Adulthood in Autism and Other Developmental Disabilities.
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Schiltz, Hillary, Clarke, Elaine, Rosen, Nicole, De La Rosa, Sofi, Masjedi, Nina, Christopher, Kourtney, and Lord, Catherine
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Adulthood ,Autism ,Family ,Support ,Humans ,Male ,Adolescent ,Female ,Developmental Disabilities ,Young Adult ,Social Support ,Longitudinal Studies ,Caregivers ,Autistic Disorder ,Family ,Adult ,Family Support - Abstract
Although caregiving responsibilities and need for support persist and evolve across the life course in families with autistic youth or youth with other developmental disabilities (DDs), little is known about support during their childs adulthood years. Therefore, the present study used a mixed-methods approach to examine change and stability in formal and informal family support across the transition to adulthood. Caregivers of 126 individuals with autism or DDs completed a modified version of the Family Support Scale, including open-ended questions, at five time points from adolescence (age 16) into young adulthood (age 22). Caregivers reported that informal support from family members was the most frequently used, helpful, and valued source of support with relative stability across time. In contrast, the reported helpfulness, use, and value of formal support (e.g., professionals, schools) for caregivers declined over time. Qualitative content analyses revealed characteristics of highly valued support included support type (e.g., instrumental or emotional) and features of the support source (e.g., their understanding). There was a shift to valuing emotional support more than instrumental support over time, especially for caregivers of less able adults. Partnership and dependability emerged as highly valued features of the support source. These findings fit within a social convoy perspective and likely reflect the service cliff experienced by autistic individuals or people with DDs and their families. As social networks shrink over time and formal services are less readily available in adulthood, remaining sources of support, particularly from family members, become increasingly important.
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- 2024
30. The radial spanning tree in hyperbolic space
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Rosen, Daniel, Schulte, Matthias, Thäle, Christoph, and Trapp, Vanessa
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Mathematics - Probability ,Primary 60D05, Secondary 51M09, 52A55, 60F05, 60G55 - Abstract
Consider a stationary Poisson process $\eta$ in a $d$-dimensional hyperbolic space of constant curvature $-\varkappa$ and let the points of $\eta$ together with a fixed origin $o$ be the vertices of a graph. Connect each point $x\in\eta$ with its radial nearest neighbour, which is the hyperbolically nearest vertex to $x$ that is closer to $o$ than $x$. This construction gives rise to the hyperbolic radial spanning tree, whose geometric properties are in the focus of this paper. In particular, the degree of the origin is studied. For increasing balls around $o$ as observation windows, expectation and variance asymptotics as well as a quantitative central limit theorem for a class of edge-length functionals are derived. The results are contrasted with those for the Euclidean radial spanning tree.
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- 2024
31. Superconformal Monodromy Defects in ABJM and mABJM Theory
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Arav, Igal, Gauntlett, Jerome P., Jiao, Yusheng, Roberts, Matthew M., and Rosen, Christopher
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High Energy Physics - Theory - Abstract
We study $D=11$ supergravity solutions which are dual to one-dimensional superconformal defects in $d=3$ SCFTs. We consider defects in ABJM theory with monodromy for $U(1)^4\subset SO(8)$ global symmetry, as well as in $\mathcal{N}=2$ mABJM SCFT, which arises from the RG flow of a mass deformation of ABJM theory, with monodromy for $U(1)^3\subset SU(3)\times U(1)$ global symmetry. We show that the defects of the two SCFTs are connected by a line of bulk marginal mass deformations and argue that they are also related by bulk RG flow. In all cases we allow for the possibility of conical singularities at the location of the defect. Various physical observables of the defects are computed including the defects conformal weight and the partition function, as well as associated supersymmetric Renyi entropies., Comment: 71 pages, 6 figures
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- 2024
32. Analysis of Habitability and Stellar Habitable Zones from Observed Exoplanets
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Jiang, Jonathan H., Rosen, Philip E., Liu, Christina X., Wen, Qianzhuang, and Chen, Yanbei
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The investigation of exoplanetary habitability is integral to advancing our knowledge of extraterrestrial life potential and detailing the environmental conditions of distant worlds. In this analysis, we explore the properties of exoplanets situated with respect to circumstellar habitable zones by implementing a sophisticated filtering methodology on data from the NASA Exoplanet Archive. This research encompasses a thorough examination of 5,595 confirmed exoplanets listed in the Archive as of March 10th, 2024, systematically evaluated according to their calculated surface temperatures and stellar classifications of their host stars, taking into account the biases implicit in the methodologies used for their discovery. Our findings elucidate distinctive patterns in exoplanetary attributes, which are significantly shaped by the spectral classifications and mass of the host stars. The insights garnered from our study not only enhance the existing models for managing burgeoning exoplanetary datasets, but also lay foundational groundwork for future explorations into the dynamic relationships between exoplanets and their stellar environments.
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- 2024
33. A new temperature evolution equation that enforces thermodynamic vapour-liquid equilibrium in multiphase flows -- application to CO2 modeling
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Kumar, Pardeep, Sanderse, Benjamin, Esquivel, Patricio I. Rosen, and Henkes, R. A. W. M.
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Physics - Fluid Dynamics ,Mathematics - Numerical Analysis - Abstract
This work presents a novel framework for numerically simulating the depressurization of tanks and pipelines containing carbon dioxide (CO2). The framework focuses on efficient solution strategies for the coupled system of fluid flow equations and thermodynamic constraints. A key contribution lies in proposing a new set of equations for phase equilibrium calculations which simplifies the traditional vapor-liquid equilibrium (VLE) calculations for two-phase CO2 mixtures. The first major novelty resides in the reduction of the conventional four-equation VLE system to a single equation, enabling efficient solution using a non-linear solver. This significantly reduces computational cost compared to traditional methods. Furthermore, a second novelty is introduced by deriving an ordinary differential equation (ODE) directly from the UV-Flash equation. This ODE can be integrated alongside the governing fluid flow equations, offering a computationally efficient approach for simulating depressurization processes., Comment: 22 pages, 15 figures, submitted to computers and fluids
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- 2024
34. Imagen 3
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Imagen-Team-Google, Baldridge, Jason, Bauer, Jakob, Bhutani, Mukul, Brichtova, Nicole, Bunner, Andrew, Chan, Kelvin, Chen, Yichang, Dieleman, Sander, Du, Yuqing, Eaton-Rosen, Zach, Fei, Hongliang, de Freitas, Nando, Gao, Yilin, Gladchenko, Evgeny, Colmenarejo, Sergio Gómez, Guo, Mandy, Haig, Alex, Hawkins, Will, Hu, Hexiang, Huang, Huilian, Igwe, Tobenna Peter, Kaplanis, Christos, Khodadadeh, Siavash, Kim, Yelin, Konyushkova, Ksenia, Langner, Karol, Lau, Eric, Luo, Shixin, Mokrá, Soňa, Nandwani, Henna, Onoe, Yasumasa, Oord, Aäron van den, Parekh, Zarana, Pont-Tuset, Jordi, Qi, Hang, Qian, Rui, Ramachandran, Deepak, Rane, Poorva, Rashwan, Abdullah, Razavi, Ali, Riachi, Robert, Srinivasan, Hansa, Srinivasan, Srivatsan, Strudel, Robin, Uria, Benigno, Wang, Oliver, Wang, Su, Waters, Austin, Wolff, Chris, Wright, Auriel, Xiao, Zhisheng, Xiong, Hao, Xu, Keyang, van Zee, Marc, Zhang, Junlin, Zhang, Katie, Zhou, Wenlei, Zolna, Konrad, Aboubakar, Ola, Akbulut, Canfer, Akerlund, Oscar, Albuquerque, Isabela, Anderson, Nina, Andreetto, Marco, Aroyo, Lora, Bariach, Ben, Barker, David, Ben, Sherry, Berman, Dana, Biles, Courtney, Blok, Irina, Botadra, Pankil, Brennan, Jenny, Brown, Karla, Buckley, John, Bunel, Rudy, Bursztein, Elie, Butterfield, Christina, Caine, Ben, Carpenter, Viral, Casagrande, Norman, Chang, Ming-Wei, Chang, Solomon, Chaudhuri, Shamik, Chen, Tony, Choi, John, Churbanau, Dmitry, Clement, Nathan, Cohen, Matan, Cole, Forrester, Dektiarev, Mikhail, Du, Vincent, Dutta, Praneet, Eccles, Tom, Elue, Ndidi, Feden, Ashley, Fruchter, Shlomi, Garcia, Frankie, Garg, Roopal, Ge, Weina, Ghazy, Ahmed, Gipson, Bryant, Goodman, Andrew, Górny, Dawid, Gowal, Sven, Gupta, Khyatti, Halpern, Yoni, Han, Yena, Hao, Susan, Hayes, Jamie, Hertz, Amir, Hirst, Ed, Hou, Tingbo, Howard, Heidi, Ibrahim, Mohamed, Ike-Njoku, Dirichi, Iljazi, Joana, Ionescu, Vlad, Isaac, William, Jana, Reena, Jennings, Gemma, Jenson, Donovon, Jia, Xuhui, Jones, Kerry, Ju, Xiaoen, Kajic, Ivana, Ayan, Burcu Karagol, Kelly, Jacob, Kothawade, Suraj, Kouridi, Christina, Ktena, Ira, Kumakaw, Jolanda, Kurniawan, Dana, Lagun, Dmitry, Lavitas, Lily, Lee, Jason, Li, Tao, Liang, Marco, Li-Calis, Maggie, Liu, Yuchi, Alberca, Javier Lopez, Lu, Peggy, Lum, Kristian, Ma, Yukun, Malik, Chase, Mellor, John, Mosseri, Inbar, Murray, Tom, Nematzadeh, Aida, Nicholas, Paul, Oliveira, João Gabriel, Ortiz-Jimenez, Guillermo, Paganini, Michela, Paine, Tom Le, Paiss, Roni, Parrish, Alicia, Peckham, Anne, Peswani, Vikas, Petrovski, Igor, Pfaff, Tobias, Pirozhenko, Alex, Poplin, Ryan, Prabhu, Utsav, Qi, Yuan, Rahtz, Matthew, Rashtchian, Cyrus, Rastogi, Charvi, Raul, Amit, Rebuffi, Sylvestre-Alvise, Ricco, Susanna, Riedel, Felix, Robinson, Dirk, Rohatgi, Pankaj, Rosgen, Bill, Rumbley, Sarah, Ryu, Moonkyung, Salgado, Anthony, Singla, Sahil, Schroff, Florian, Schumann, Candice, Shah, Tanmay, Shillingford, Brendan, Shivakumar, Kaushik, Shtatnov, Dennis, Singer, Zach, Sluzhaev, Evgeny, Sokolov, Valerii, Sottiaux, Thibault, Stimberg, Florian, Stone, Brad, Stutz, David, Su, Yu-Chuan, Tabellion, Eric, Tang, Shuai, Tao, David, Thomas, Kurt, Thornton, Gregory, Toor, Andeep, Udrescu, Cristian, Upadhyay, Aayush, Vasconcelos, Cristina, Vasiloff, Alex, Voynov, Andrey, Walker, Amanda, Wang, Luyu, Wang, Miaosen, Wang, Simon, Wang, Stanley, Wang, Qifei, Wang, Yuxiao, Weisz, Ágoston, Wiles, Olivia, Wu, Chenxia, Xu, Xingyu Federico, Xue, Andrew, Yang, Jianbo, Yu, Luo, Yurtoglu, Mete, Zand, Ali, Zhang, Han, Zhang, Jiageng, Zhao, Catherine, Zhaxybay, Adilet, Zhou, Miao, Zhu, Shengqi, Zhu, Zhenkai, Bloxwich, Dawn, Bordbar, Mahyar, Cobo, Luis C., Collins, Eli, Dai, Shengyang, Doshi, Tulsee, Dragan, Anca, Eck, Douglas, Hassabis, Demis, Hsiao, Sissie, Hume, Tom, Kavukcuoglu, Koray, King, Helen, Krawczyk, Jack, Li, Yeqing, Meier-Hellstern, Kathy, Orban, Andras, Pinsky, Yury, Subramanya, Amar, Vinyals, Oriol, Yu, Ting, and Zwols, Yori
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Computer Science - Computer Vision and Pattern Recognition - Abstract
We introduce Imagen 3, a latent diffusion model that generates high quality images from text prompts. We describe our quality and responsibility evaluations. Imagen 3 is preferred over other state-of-the-art (SOTA) models at the time of evaluation. In addition, we discuss issues around safety and representation, as well as methods we used to minimize the potential harm of our models.
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- 2024
35. Visual Analysis of GitHub Issues to Gain Insights
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Proma, Rifat Ara and Rosen, Paul
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Computer Science - Software Engineering ,Computer Science - Human-Computer Interaction - Abstract
Version control systems are integral to software development, with GitHub emerging as a popular online platform due to its comprehensive project management tools, including issue tracking and pull requests. However, GitHub lacks a direct link between issues and commits, making it difficult for developers to understand how specific issues are resolved. Although GitHub's Insights page provides some visualization for repository data, the representation of issues and commits related data in a textual format hampers quick evaluation of issue management. This paper presents a prototype web application that generates visualizations to offer insights into issue timelines and reveals different factors related to issues. It focuses on the lifecycle of issues and depicts vital information to enhance users' understanding of development patterns in their projects. We demonstrate the effectiveness of our approach through case studies involving three open-source GitHub repositories. Furthermore, we conducted a user evaluation to validate the efficacy of our prototype in conveying crucial repository information more efficiently and rapidly.
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- 2024
36. Uncertainty Visualization of Critical Points of 2D Scalar Fields for Parametric and Nonparametric Probabilistic Models
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Athawale, Tushar M., Wang, Zhe, Pugmire, David, Moreland, Kenneth, Gong, Qian, Klasky, Scott, Johnson, Chris R., and Rosen, Paul
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Computer Science - Graphics - Abstract
This paper presents a novel end-to-end framework for closed-form computation and visualization of critical point uncertainty in 2D uncertain scalar fields. Critical points are fundamental topological descriptors used in the visualization and analysis of scalar fields. The uncertainty inherent in data (e.g., observational and experimental data, approximations in simulations, and compression), however, creates uncertainty regarding critical point positions. Uncertainty in critical point positions, therefore, cannot be ignored, given their impact on downstream data analysis tasks. In this work, we study uncertainty in critical points as a function of uncertainty in data modeled with probability distributions. Although Monte Carlo (MC) sampling techniques have been used in prior studies to quantify critical point uncertainty, they are often expensive and are infrequently used in production-quality visualization software. We, therefore, propose a new end-to-end framework to address these challenges that comprises a threefold contribution. First, we derive the critical point uncertainty in closed form, which is more accurate and efficient than the conventional MC sampling methods. Specifically, we provide the closed-form and semianalytical (a mix of closed-form and MC methods) solutions for parametric (e.g., uniform, Epanechnikov) and nonparametric models (e.g., histograms) with finite support. Second, we accelerate critical point probability computations using a parallel implementation with the VTK-m library, which is platform portable. Finally, we demonstrate the integration of our implementation with the ParaView software system to demonstrate near-real-time results for real datasets., Comment: 9 pages paper + 2 page references, 8 figures, IEEE VIS 2024 paper to be published as a special issue of IEEE Transactions on Visualization and Computer Graphics (TVCG)
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- 2024
37. McGAN: Generating Manufacturable Designs by Embedding Manufacturing Rules into Conditional Generative Adversarial Network
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Wang, Zhichao, Yan, Xiaoliang, Melkote, Shreyes, and Rosen, David
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Generative design (GD) methods aim to automatically generate a wide variety of designs that satisfy functional or aesthetic design requirements. However, research to date generally lacks considerations of manufacturability of the generated designs. To this end, we propose a novel GD approach by using deep neural networks to encode design for manufacturing (DFM) rules, thereby modifying part designs to make them manufacturable by a given manufacturing process. Specifically, a three-step approach is proposed: first, an instance segmentation method, Mask R-CNN, is used to decompose a part design into subregions. Second, a conditional generative adversarial neural network (cGAN), Pix2Pix, transforms unmanufacturable decomposed subregions into manufacturable subregions. The transformed subregions of designs are subsequently reintegrated into a unified manufacturable design. These three steps, Mask-RCNN, Pix2Pix, and reintegration, form the basis of the proposed Manufacturable conditional GAN (McGAN) framework. Experimental results show that McGAN can transform existing unmanufacturable designs to generate their corresponding manufacturable counterparts automatically that realize the specified manufacturing rules in an efficient and robust manner. The effectiveness of McGAN is demonstrated through two-dimensional design case studies of an injection molding process.
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- 2024
38. Machine Learning for Improved Current Density Reconstruction from 2D Vector Magnetic Images
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Reed, Niko R., Bhutto, Danyal, Turner, Matthew J., Daly, Declan M., Oliver, Sean M., Tang, Jiashen, Olsson, Kevin S., Langellier, Nicholas, Ku, Mark J. H., Rosen, Matthew S., and Walsworth, Ronald L.
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Physics - Computational Physics ,Physics - Applied Physics ,Quantum Physics - Abstract
The reconstruction of electrical current densities from magnetic field measurements is an important technique with applications in materials science, circuit design, quality control, plasma physics, and biology. Analytic reconstruction methods exist for planar currents, but break down in the presence of high spatial frequency noise or large standoff distance, restricting the types of systems that can be studied. Here, we demonstrate the use of a deep convolutional neural network for current density reconstruction from two-dimensional (2D) images of vector magnetic fields acquired by a quantum diamond microscope (QDM) utilizing a surface layer of Nitrogen Vacancy (NV) centers in diamond. Trained network performance significantly exceeds analytic reconstruction for data with high noise or large standoff distances. This machine learning technique can perform quality inversions on lower SNR data, reducing the data collection time by a factor of about 400 and permitting reconstructions of weaker and three-dimensional current sources., Comment: 17 pages, 10 figures. Includes Supplemental Information
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- 2024
39. Cooling of gold cluster anions, Au$_N^-$, $N=2-13,15$, in a cryogenic ion-beam storage ring
- Author
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Hansen, Klavs, Weihao, Tian, Anderson, Emma K., Björkhage, Mikael, Cederquist, Henrik, MingChao, Ji, Rosén, Stefan, Schmidt-May, Alice, Stockett, Mark H., Zettergren, Henning, Zhaunerchyk, Vitali, and Schmidt, Henning T.
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Physics - Atomic Physics ,Physics - Atomic and Molecular Clusters - Abstract
We have measured the spontaneous and photo-induced decays of anionic gold clusters, Au$_N^-$, with sizes ranging from $N = 2$ to 13, and 15. After production in a sputter ion source, the size-selected clusters were stored in the cryogenic electrostatic ion-beam storage ring DESIREE and their neutralization decays were measured for storage times between 0.1 and 100 s. The dimer was observed to decay by electron emission in parallel to neutral atom emission at long times, analogously to the behavior of copper and silver dimers, implying a breakdown of the Born-Oppenheimer approximation. Radiative cooling is observed for all cluster sizes except for the dimer. The decay rates of clusters $N=3,6,8-13,15$ show only a single radiative cooling time. For $N=6-13$ the cooling times have a strong odd-even oscillation with an amplitude that decrease with cluster size, and with the even $N$ having the fast cooling. We compare our results with previous measurements of radiative cooling rates of the corresponding cationic gold clusters, Au$_N^+$, which also show an odd-even effect with a similar oscillation amplitude but at orders of magnitude shorter time scales, and out of phase with the anions., Comment: 12 pages, 12 figures
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- 2024
40. AI Age Discrepancy: A Novel Parameter for Frailty Assessment in Kidney Tumor Patients
- Author
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Seshadri, Rikhil, Siva, Jayant, Bartholomew, Angelica, Goebel, Clara, Wallerstein-King, Gabriel, Morato, Beatriz López, Heller, Nicholas, Scovell, Jason, Campbell, Rebecca, Wood, Andrew, Ozery-Flato, Michal, Barros, Vesna, Gabrani, Maria, Rosen-Zvi, Michal, Tejpaul, Resha, Ramesh, Vidhyalakshmi, Papanikolopoulos, Nikolaos, Regmi, Subodh, Ward, Ryan, Abouassaly, Robert, Campbell, Steven C., Remer, Erick, and Weight, Christopher
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Kidney cancer is a global health concern, and accurate assessment of patient frailty is crucial for optimizing surgical outcomes. This paper introduces AI Age Discrepancy, a novel metric derived from machine learning analysis of preoperative abdominal CT scans, as a potential indicator of frailty and postoperative risk in kidney cancer patients. This retrospective study of 599 patients from the 2023 Kidney Tumor Segmentation (KiTS) challenge dataset found that a higher AI Age Discrepancy is significantly associated with longer hospital stays and lower overall survival rates, independent of established factors. This suggests that AI Age Discrepancy may provide valuable insights into patient frailty and could thus inform clinical decision-making in kidney cancer treatment., Comment: 10 pages, 3 figures, 2 tables
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- 2024
41. XAMI -- A Benchmark Dataset for Artefact Detection in XMM-Newton Optical Images
- Author
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Dima, Elisabeta-Iulia, Gómez, Pablo, Kruk, Sandor, Kretschmar, Peter, Rosen, Simon, and Popa, Călin-Adrian
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Computer Science - Computer Vision and Pattern Recognition ,Astrophysics - Instrumentation and Methods for Astrophysics ,Computer Science - Machine Learning - Abstract
Reflected or scattered light produce artefacts in astronomical observations that can negatively impact the scientific study. Hence, automated detection of these artefacts is highly beneficial, especially with the increasing amounts of data gathered. Machine learning methods are well-suited to this problem, but currently there is a lack of annotated data to train such approaches to detect artefacts in astronomical observations. In this work, we present a dataset of images from the XMM-Newton space telescope Optical Monitoring camera showing different types of artefacts. We hand-annotated a sample of 1000 images with artefacts which we use to train automated ML methods. We further demonstrate techniques tailored for accurate detection and masking of artefacts using instance segmentation. We adopt a hybrid approach, combining knowledge from both convolutional neural networks (CNNs) and transformer-based models and use their advantages in segmentation. The presented method and dataset will advance artefact detection in astronomical observations by providing a reproducible baseline. All code and data are made available (https://github.com/ESA-Datalabs/XAMI-model and https://github.com/ESA-Datalabs/XAMI-dataset)., Comment: Accepted for oral presentation at SPAICE 2024
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- 2024
42. Suppressing Counter-Rotating Errors for Fast Single-Qubit Gates with Fluxonium
- Author
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Rower, David A., Ding, Leon, Zhang, Helin, Hays, Max, An, Junyoung, Harrington, Patrick M., Rosen, Ilan T., Gertler, Jeffrey M., Hazard, Thomas M., Niedzielski, Bethany M., Schwartz, Mollie E., Gustavsson, Simon, Serniak, Kyle, Grover, Jeffrey A., and Oliver, William D.
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Quantum Physics - Abstract
Qubit decoherence unavoidably degrades the fidelity of quantum logic gates. Accordingly, realizing gates that are as fast as possible is a guiding principle for qubit control, necessitating protocols for mitigating error channels that become significant as gate time is decreased. One such error channel arises from the counter-rotating component of strong, linearly polarized drives. This error channel is particularly important when gate times approach the qubit Larmor period and represents the dominant source of infidelity for sufficiently fast single-qubit gates with low-frequency qubits such as fluxonium. In this work, we develop and demonstrate two complementary protocols for mitigating this error channel. The first protocol realizes circularly polarized driving in circuit quantum electrodynamics (QED) through simultaneous charge and flux control. The second protocol -- commensurate pulses -- leverages the coherent and periodic nature of counter-rotating fields to regularize their contributions to gates, enabling single-qubit gate fidelities reliably exceeding $99.997\%$. This protocol is platform independent and requires no additional calibration overhead. This work establishes straightforward strategies for mitigating counter-rotating effects from strong drives in circuit QED and other platforms, which we expect to be helpful in the effort to realize high-fidelity control for fault-tolerant quantum computing.
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- 2024
43. The TEMPO Survey II: Science Cases Leveraged from a Proposed 30-Day Time Domain Survey of the Orion Nebula with the Nancy Grace Roman Space Telescope
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Soares-Furtado, Melinda, Limbach, Mary Anne, Vanderburg, Andrew, Bally, John, Becker, Juliette, Rosen, Anna L., Bouma, Luke G., Vos, Johanna M., Howell, Steve B., Beatty, Thomas G., Best, William M. J., Cody, Anne Marie, Distler, Adam, D'Onghia, Elena, Heller, René, Hensley, Brandon S., Hinkel, Natalie R., Jackson, Brian, Kounkel, Marina, Kraus, Adam, Mann, Andrew W., Marston, Nicholas T., Robberto, Massimo, Rodriguez, Joseph E., Steffen, Jason H., Teske, Johanna K., Townsend, Richard, Yarza, Ricardo, and Youngblood, Allison
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The TEMPO (Transiting Exosatellites, Moons, and Planets in Orion) Survey is a proposed 30-day observational campaign using the Nancy Grace Roman Space Telescope. By providing deep, high-resolution, short-cadence infrared photometry of a dynamic star-forming region, TEMPO will investigate the demographics of exosatellites orbiting free-floating planets and brown dwarfs -- a largely unexplored discovery space. Here, we present the simulated detection yields of three populations: extrasolar moon analogs orbiting free-floating planets, exosatellites orbiting brown dwarfs, and exoplanets orbiting young stars. Additionally, we outline a comprehensive range of anticipated scientific outcomes accompanying such a survey. These science drivers include: obtaining observational constraints to test prevailing theories of moon, planet, and star formation; directly detecting widely separated exoplanets orbiting young stars; investigating the variability of young stars and brown dwarfs; constraining the low-mass end of the stellar initial mass function; constructing the distribution of dust in the Orion Nebula and mapping evolution in the near-infrared extinction law; mapping emission features that trace the shocked gas in the region; constructing a dynamical map of Orion members using proper motions; and searching for extragalactic sources and transients via deep extragalactic observations reaching a limiting magnitude of $m_{AB}=29.7$\,mag (F146 filter)., Comment: 15 pages, 6 figures, submitted to OJAp
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- 2024
44. Sharp weighted non-tangential maximal estimates via Carleson-sparse domination
- Author
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Rosén, Andreas
- Subjects
Mathematics - Classical Analysis and ODEs ,42B35, 42B20, 42B37 - Abstract
We prove sharp weighted estimates for the non-tangential maximal function of singular integrals mapping functions from $\mathbf{R}^n$ to the half-space in $\mathbf{R}^{1+n}$ above $\mathbf{R}^n$. The proof is based on pointwise sparse domination of the adjoint singular integrals that map functions from the half-space back to the boundary. It is proved that these map $L_1$ functions in the half-space to weak $L_1$ functions on the boundary. From this a non-standard sparse domination of the singular integrals is established, where averages have been replaced by Carleson averages., Comment: Minor corrections
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- 2024
45. P-TECH 9-14 Pathways to Success: Implementation, Impact, and Cost Findings from the New York City P-TECH 9-14 Schools Evaluation. Executive Summary
- Author
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MDRC, Rosen, Rachel, Alterman, Emma, Treskon, Louisa, Parise, Leigh, Dixon, Michelle, and Wuest, Cassie
- Abstract
The New York City P-TECH 9-14 schools are an educational model that ties together the secondary, higher education, and workforce systems to improve outcomes across domains. The distinguishing feature of the model is a partnership among a high school, a community college, and one or more employer partners that focuses on preparing students for both college and careers within six years. P-TECH 9-14 schools collaborate with local colleges to provide students with an opportunity to earn a high school diploma within four years, followed by a cost-free, industry-recognized associate's degree. During the six-year program, employer partners provide students with work-based learning experiences such as internships, mentoring, and job shadowing. This study provides impact, implementation, and cost study findings from the first rigorous evaluation of the model, examining the first seven P-TECH 9-14 schools that opened in New York City. The study follows entering classes of students for seven years after they begin ninth grade, which would carry them through the end of their expected high school graduations and through three years of postsecondary education. The study takes advantage of the random lottery process created by the New York City high school admissions system to identify the model's effects: It compares students who won lotteries to attend P-TECH 9-14 schools (the P-TECH 9-14 group) with students who applied but did not win (the comparison group). It also includes an in-depth implementation study that assesses how schools carried out the model, and a cost-effectiveness study that examines costs per college degree earned for P-TECH 9-14 schools compared with other schools. [For the full report, see ED632477.]
- Published
- 2023
46. Evidence of Accelerated Improvement of Claim-Evidence-Reasoning (CER) Skills with BrainPOP Science: A Case Study of Southeastern Region Districts
- Author
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Melissa Hogan, Michelle Newstadt, Maneeza Dawood, Ilia Rushkin, and Yigal Rosen
- Abstract
BrainPOP Science is a research-based program that has been shown to be effective in improving and quickly developing students' scientific reasoning skills. This white paper presents a comprehensive case study conducted in school districts in the Southeastern United States. BrainPOP Science is one of the leading supplemental middle school programs. This study investigated the effectiveness of BrainPOP Science for enhancing students' proficiency in constructing scientific explanations and arguments by utilizing evidence and reasoning according to the Claim-Evidence-Reasoning (CER) framework. Data were collected from students' first and fourth CER submissions to explore changes in CER skills over time. A multivariate analysis of covariance (MANCOVA) was conducted to assess the joint significance of the difference between students' first and fourth claim, evidence, and reasoning subscores and total CER scores, as well as to examine the role of BrainPOP Science usage as a covariate. The results reveal significant learning gains on average between students' first and fourth CER scores. Multivariate analysis found the model was jointly significant for the total CER score, as well as each claim, evidence and reasoning subscores. A significant effect of BrainPOP usage was also observed, such that any usage (low, moderate, high) increased the total CER score, and evidence subscores. Additionally, moderate usage increased claim subscores, and moderate and high usage increased reasoning subscores. A key implication of this research is the expansion of teacher capacity. BrainPOP Science provides educators with ready-to-use, standards-aligned investigations that effectively support multidimensional science learning. The platform offers a scaffolded approach to evidence-based writing, incorporating exemplar answers and assessment rationales. This strategic integration of teaching resources empowers educators to confidently guide students in their development of Claim-Evidence-Reasoning skills, which is transferable to high-school readiness and preparation for state summative assessments.
- Published
- 2023
47. Career and Technical Education: Current Policy, Prominent Programs, and Evidence. Working Paper
- Author
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MDRC, Klein, Sabrina, Rosen, Rachel, Beal, Katie, and Salimi, Sarah
- Abstract
Interest in the field of career and technical education (CTE) has experienced a resurgence over the last decade, as the global economy has grown increasingly competitive while students have continued to leave school underprepared for well-paying twenty-first century jobs. Together and separately, the education and workforce sectors have sought to address these challenges and better prepare students for viable economic futures. The results have been many new, innovative programs at both the secondary and postsecondary education levels that seek to give students technical training for specific careers, general training to prepare them for the workplace, and work-based learning opportunities where they can develop connections to employers and the workforce. While there are still many under-researched areas in CTE, this paper attempts to capture the evidence that has emerged--identifying areas where there is more evidence as well as areas where gaps in evidence still exist. The studies that have been conducted on CTE have demonstrated that it shows promise, but it is imperative to continue building evidence, particularly where there is policy interest and momentum but little data. Doing so will help demonstrate how those programs and models serve students and ensure that the continued scaling up of CTE is supported by a rigorous evidence base. This paper begins with an overview of the issues in the education system and the labor market that have led to the current revival of CTE. It argues that the skills today's employers need are not the ones schools are providing. The paper continues with a description of how various policies have fostered the growth of CTE. In the next section, it provides details on the types of programs and institutions that offer CTE, and the evidence base to support each of them. The paper provides evidence on the effectiveness of CTE at different educational levels, and for specific subgroups, including students with disabilities, and by gender. Further, the paper provides an overview of the available evidence to support different kinds of programs offered at both secondary and postsecondary education levels, touching on the amount of evidence available in each area and the level of rigor used in the studies that generated that evidence. The paper concludes by suggesting that while CTE instruction at the secondary and postsecondary levels could bolster students' economic mobility by helping them gain postsecondary credentials and obtain higher-paying jobs, there are challenges involved in turning that promise into reality. Investments in evidence-based practices can give CTE programs a better chance at success.
- Published
- 2023
48. Comorbid neuropathology and atypical presentation of Alzheimer's disease
- Author
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Pina‐Escudero, Stefanie D, La Joie, Renaud, Spina, Salvatore, Hwang, Ji‐Hye, Miller, Zachary A, Huang, Eric J, Grant, Harli, Mundada, Nidhi S, Boxer, Adam L, Gorno‐Tempini, Maria Luisa, Rosen, Howard J, Kramer, Joel H, Miller, Bruce L, Seeley, William W, Rabinovici, Gil D, and Grinberg, Lea Tenenholz
- Subjects
Biological Psychology ,Psychology ,Acquired Cognitive Impairment ,Neurodegenerative ,Neurosciences ,Brain Disorders ,Alzheimer's Disease ,Dementia ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Aging ,2.1 Biological and endogenous factors ,4.1 Discovery and preclinical testing of markers and technologies ,Neurological ,atypical Alzheimer's disease ,clinicopathological correlation ,comorbidities ,neuropathology ,post mortem ,selective vulnerability ,Genetics ,Biological psychology - Abstract
IntroductionAlzheimer's disease (AD) neuropathological changes present with amnestic and nonamnestic (atypical) syndromes. The contribution of comorbid neuropathology as a substratum of atypical expression of AD remains under investigated.MethodsWe examined whether atypical AD exhibited increased comorbid neuropathology compared to typical AD and if such neuropathologies contributed to the accelerated clinical decline in atypical AD.ResultsWe examined 60 atypical and 101 typical AD clinicopathological cases. The number of comorbid pathologies was similar between the groups (p = 0.09). Argyrophilic grain disease was associated with atypical presentation (p = 0.008) after accounting for sex, age of onset, and disease duration. Vascular brain injury was more common in typical AD (p = 0.022). Atypical cases had a steeper Mini-Mental Status Examination (MMSE) decline over time (p = 0.033).DiscussionComorbid neuropathological changes are unlikely to contribute to atypical AD presentation and the steeper cognitive decline seen in this cohort.HighlightsAutopsy cohort of 60 atypical and 101 typical AD; does comorbid pathology explain atypical presentation?Atypical versus Typical AD: No significant differences in comorbid neuropathologies were found (p = 0.09).Argyrophilic Grain Disease Association: significantly correlates with atypical AD presentations, suggesting a unique neuropathological pattern (p = 0.008).Vascular Brain Injury Prevalence: Vascular brain injury is more common in typical AD than in atypical AD (p = 0.022).Cognitive Decline in Atypical AD: Atypical AD patients experience a steeper cognitive decline measured by MMSE than those with typical AD despite lacking more comorbid neuropathology, highlighting the severity of atypical AD pathogenesis (p = 0.033).
- Published
- 2024
49. Stewardship Prompts to Improve Antibiotic Selection for Urinary Tract Infection
- Author
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Gohil, Shruti K, Septimus, Edward, Kleinman, Ken, Varma, Neha, Avery, Taliser R, Heim, Lauren, Rahm, Risa, Cooper, William S, Cooper, Mandelin, McLean, Laura E, Nickolay, Naoise G, Weinstein, Robert A, Burgess, L Hayley, Coady, Micaela H, Rosen, Edward, Sljivo, Selsebil, Sands, Kenneth E, Moody, Julia, Vigeant, Justin, Rashid, Syma, Gilbert, Rebecca F, Smith, Kim N, Carver, Brandon, Poland, Russell E, Hickok, Jason, Sturdevant, SG, Calderwood, Michael S, Weiland, Anastasiia, Kubiak, David W, Reddy, Sujan, Neuhauser, Melinda M, Srinivasan, Arjun, Jernigan, John A, Hayden, Mary K, Gowda, Abinav, Eibensteiner, Katyuska, Wolf, Robert, Perlin, Jonathan B, Platt, Richard, and Huang, Susan S
- Subjects
Medical Microbiology ,Biomedical and Clinical Sciences ,Clinical Sciences ,Infectious Diseases ,Urologic Diseases ,Patient Safety ,Women's Health ,Infection ,Adult ,Aged ,Female ,Humans ,Male ,Middle Aged ,Anti-Bacterial Agents ,Antimicrobial Stewardship ,Drug Resistance ,Multiple ,Bacterial ,Hospitals ,Community ,Length of Stay ,Medical Order Entry Systems ,Urinary Tract Infections ,Aged ,80 and over ,Medical and Health Sciences ,General & Internal Medicine ,Biomedical and clinical sciences ,Health sciences - Abstract
ImportanceUrinary tract infection (UTI) is the second most common infection leading to hospitalization and is often associated with gram-negative multidrug-resistant organisms (MDROs). Clinicians overuse extended-spectrum antibiotics although most patients are at low risk for MDRO infection. Safe strategies to limit overuse of empiric antibiotics are needed.ObjectiveTo evaluate whether computerized provider order entry (CPOE) prompts providing patient- and pathogen-specific MDRO risk estimates could reduce use of empiric extended-spectrum antibiotics for treatment of UTI.Design, setting, and participantsCluster-randomized trial in 59 US community hospitals comparing the effect of a CPOE stewardship bundle (education, feedback, and real-time and risk-based CPOE prompts; 29 hospitals) vs routine stewardship (n = 30 hospitals) on antibiotic selection during the first 3 hospital days (empiric period) in noncritically ill adults (≥18 years) hospitalized with UTI with an 18-month baseline (April 1, 2017-September 30, 2018) and 15-month intervention period (April 1, 2019-June 30, 2020).InterventionsCPOE prompts recommending empiric standard-spectrum antibiotics in patients ordered to receive extended-spectrum antibiotics who have low estimated absolute risk (
- Published
- 2024
50. Stewardship Prompts to Improve Antibiotic Selection for Pneumonia
- Author
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Gohil, Shruti K, Septimus, Edward, Kleinman, Ken, Varma, Neha, Avery, Taliser R, Heim, Lauren, Rahm, Risa, Cooper, William S, Cooper, Mandelin, McLean, Laura E, Nickolay, Naoise G, Weinstein, Robert A, Burgess, L Hayley, Coady, Micaela H, Rosen, Edward, Sljivo, Selsebil, Sands, Kenneth E, Moody, Julia, Vigeant, Justin, Rashid, Syma, Gilbert, Rebecca F, Smith, Kim N, Carver, Brandon, Poland, Russell E, Hickok, Jason, Sturdevant, SG, Calderwood, Michael S, Weiland, Anastasiia, Kubiak, David W, Reddy, Sujan, Neuhauser, Melinda M, Srinivasan, Arjun, Jernigan, John A, Hayden, Mary K, Gowda, Abinav, Eibensteiner, Katyuska, Wolf, Robert, Perlin, Jonathan B, Platt, Richard, and Huang, Susan S
- Subjects
Medical Microbiology ,Biomedical and Clinical Sciences ,Clinical Sciences ,Pneumonia ,Pneumonia & Influenza ,Infectious Diseases ,Patient Safety ,Comparative Effectiveness Research ,Lung ,Clinical Research ,Infection ,Aged ,Female ,Humans ,Male ,Middle Aged ,Anti-Bacterial Agents ,Antimicrobial Stewardship ,Drug Resistance ,Multiple ,Bacterial ,Hospitalization ,Medical Order Entry Systems ,Pneumonia ,Bacterial ,United States ,Aged ,80 and over ,Medical and Health Sciences ,General & Internal Medicine ,Biomedical and clinical sciences ,Health sciences - Abstract
ImportancePneumonia is the most common infection requiring hospitalization and is a major reason for overuse of extended-spectrum antibiotics. Despite low risk of multidrug-resistant organism (MDRO) infection, clinical uncertainty often drives initial antibiotic selection. Strategies to limit empiric antibiotic overuse for patients with pneumonia are needed.ObjectiveTo evaluate whether computerized provider order entry (CPOE) prompts providing patient- and pathogen-specific MDRO infection risk estimates could reduce empiric extended-spectrum antibiotics for non-critically ill patients admitted with pneumonia.Design, setting, and participantsCluster-randomized trial in 59 US community hospitals comparing the effect of a CPOE stewardship bundle (education, feedback, and real-time MDRO risk-based CPOE prompts; n = 29 hospitals) vs routine stewardship (n = 30 hospitals) on antibiotic selection during the first 3 hospital days (empiric period) in non-critically ill adults (≥18 years) hospitalized with pneumonia. There was an 18-month baseline period from April 1, 2017, to September 30, 2018, and a 15-month intervention period from April 1, 2019, to June 30, 2020.InterventionCPOE prompts recommending standard-spectrum antibiotics in patients ordered to receive extended-spectrum antibiotics during the empiric period who have low estimated absolute risk (
- Published
- 2024
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