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1. Biliary complications after adult-to-adult living-donor liver transplantation: An international multicenter study of 3633 cases

Author

Li, Zhihao, Rammohan, Ashwin, Gunasekaran, Vasanthakumar, Hong, Suyoung, Chih-Yi Chen, Itsuko, Kim, Jongman, Hervera Marquez, Kris Ann, Hsu, Shih-Chao, Kirimker, Elvan Onur, Akamatsu, Nobuhisa, Shaked, Oren, Finotti, Michele, Yeow, Marcus, Genedy, Lara, Dutkowski, Philipp, Nadalin, Silvio, Boehnert, Markus U., Polak, Wojciech G., Bonney, Glenn K., Mathur, Abhishek, Samstein, Benjamin, Emond, Jean C., Testa, Giuliano, Olthoff, Kim M., Rosen, Charles B., Heimbach, Julie K., Taner, Timucin, Wong, Tiffany CL., Lo, Chung-Mau, Hasegawa, Kiyoshi, Balci, Deniz, Cattral, Mark, Sapisochin, Gonzalo, Selzner, Nazia, Jeng, Long-Bin, Broering, Dieter, Joh, Jae-Won, Chen, Chao-Long, Suh, Kyung-Suk, Rela, Mohamed, and Clavien, Pierre-Alain

Published
2024
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2. Novel Benchmark for Adult-to-Adult Living-donor Liver Transplantation: Integrating Eastern and Western Experiences

Author

Li, Zhihao, Rammohan, Ashwin, Gunasekaran, Vasanthakumar, Hong, Suyoung, Chen, Itsuko Chih-Yi, Kim, Jongman, Hervera Marquez, Kris Ann, Hsu, Shih Chao, Kirimker, Elvan Onur, Akamatsu, Nobuhisa, Shaked, Oren, Finotti, Michele, Yeow, Marcus, Genedy, Lara, Dutkowski, Philipp, Nadalin, Silvio, Boehnert, Markus U., Polak, Wojciech G., Bonney, Glenn K., Mathur, Abhishek, Samstein, Benjamin, Emond, Jean C., Testa, Giuliano, Olthoff, Kim M., Rosen, Charles B., Heimbach, Julie K., Taner, Timucin, Wong, Tiffany CL., Lo, Chung-Mau, Hasegawa, Kiyoshi, Balci, Deniz, Cattral, Mark, Sapisochin, Gonzalo, Selzner, Nazia, Bin Jeng, Long, Broering, Dieter, Joh, Jae-Won, Chen, Chao-Long, Suk, Kyung-Suh, Rela, Mohamed, and Clavien, Pierre-Alain

Published
2023
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4. Controversy Over Liver Transplantation or Resection for Neuroendocrine Liver Metastasis: Tumor Biology Cuts the Deal

Author

Eshmuminov, Dilmurodjon, Studer, Debora J., Lopez Lopez, Victor, Schneider, Marcel A., Lerut, Jan, Lo, Mary, Sher, Linda, Musholt, Thomas J., Lozan, Oana, Bouzakri, Nabila, Sposito, Carlo, Miceli, Rosalba, Barat, Shoma, Morris, David, Oehler, Helga, Schreckenbach, Teresa, Husen, Peri, Rosen, Charles B., Gores, Gregory J., Masui, Toshihiko, Cheung, Tan-To, Kim-Fuchs, Corina, Perren, Aurel, Dutkowski, Philipp, Petrowsky, Henrik, Thiis-Evensen, Espen, Line, Pål-Dag, Grat, Michal, Partelli, Stefano, Falconi, Massimo, Tanno, Lulu, Robles-Campos, Ricardo, Mazzaferro, Vincenzo, Clavien, Pierre-Alain, and Lehmann, Kuno

Published
2023
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6. Metabolomic Profiling of Portal Blood and Bile Reveals Metabolic Signatures of Primary Sclerosing Cholangitis

Author

Tietz-Bogert, Pamela S, Kim, Minsuk, Cheung, Angela, Tabibian, James H, Heimbach, Julie K, Rosen, Charles B, Nandakumar, Madhumitha, Lazaridis, Konstantinos N, LaRusso, Nicholas F, Sung, Jaeyun, and O’Hara, Steven P

Subjects
Analytical Chemistry, Chemical Sciences, Clinical Research, Liver Disease, Digestive Diseases, Chronic Liver Disease and Cirrhosis, Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, Oral and gastrointestinal, Adult, Bile, Cholangitis, Sclerosing, Female, Humans, Lipid Metabolism, Male, Metabolome, Metabolomics, Middle Aged, Phenotype, Principal Component Analysis, Young Adult, primary sclerosing cholangitis, portal venous blood, bile, metabolomics, enterohepatic circulation, Other Chemical Sciences, Genetics, Other Biological Sciences, Chemical Physics, Biochemistry and cell biology, Microbiology, Medicinal and biomolecular chemistry
Abstract

Primary sclerosing cholangitis (PSC) is a pathogenically complex, chronic, fibroinflammatory disorder of the bile ducts without known etiology or effective pharmacotherapy. Emerging in vitro and in vivo evidence support fundamental pathophysiologic mechanisms in PSC centered on enterohepatic circulation. To date, no studies have specifically interrogated the chemical footprint of enterohepatic circulation in PSC. Herein, we evaluated the metabolome and lipidome of portal venous blood and bile obtained at the time of liver transplantation in patients with PSC (n = 7) as compared to individuals with noncholestatic, end-stage liver disease (viral, metabolic, etc. (disease control, DC, n = 19)) and to nondisease controls (NC, living donors, n = 12). Global metabolomic and lipidomic profiling was performed on serum derived from portal venous blood (portal serum) and bile using ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and differential mobility spectroscopy-mass spectroscopy (DMS-MS; complex lipid platform). The Mann⁻Whitney U test was used to identify metabolites that significantly differed between groups. Principal-component analysis (PCA) showed significant separation of both PSC and DC from NC for both portal serum and bile. Metabolite set enrichment analysis of portal serum and bile demonstrated that the liver-disease cohorts (PSC and DC) exhibited similar enrichment in several metabolite categories compared to NC. Interestingly, the bile in PSC was uniquely enriched for dipeptide and polyamine metabolites. Finally, analysis of patient-matched portal serum and biliary metabolome revealed that these biological fluids were more homogeneous in PSC than in DC or NC, suggesting aberrant bile formation and enterohepatic circulation. In summary, PSC and DC patients exhibited alterations in several metabolites in portal serum and bile, while PSC patients exhibited a unique bile metabolome. These specific alterations in PSC are amenable to hypothesis testing and, potentially, therapeutic pharmacologic manipulation.

Published
2018

9. Liver Transplantation as a New Standard of Care in Patients With Perihilar Cholangiocarcinoma? Results From an International Benchmark Study

Author

Breuer, Eva, Mueller, Matteo, Doyle, Majella B., Yang, Liu, Darwish Murad, Sarwa, Anwar, Imran J., Merani, Shaheed, Limkemann, Ashley, Jeddou, Heithem, Kim, Steven C., López-López, Victor, Nassar, Ahmed, Hoogwater, Frederik J.H., Vibert, Eric, De Oliveira, Michelle L., Cherqui, Daniel, Porte, Robert J., Magliocca, Joseph F., Fischer, Lutz, Fondevila, Constantino, Zieniewicz, Krzysztof, Ramírez, Pablo, Foley, David P., Boudjema, Karim, Schenk, Austin D., Langnas, Alan N., Knechtle, Stuart, Polak, Wojciech G., Taner, C. Burcin, Chapman, William C., Rosen, Charles B., Gores, Gregory J., Dutkowski, Philipp, Heimbach, Julie K., and Clavien, Pierre-Alain

Published
2022
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18. Contributors

Author

Abbas, Abbas E., primary, Adams, David B., additional, Aggarwal, Piyush, additional, Ahmed, Bestoun H., additional, Albanese, Craig, additional, Albert, Matthew R., additional, Ali, Abubaker, additional, Alicuben, Evan, additional, Allaix, Marco E., additional, Altman, Ashley, additional, Ando, Hisami, additional, Andolfi, Ciro, additional, Annamalai, Alagappan, additional, Asare, Elliot A., additional, Asti, Emanuele, additional, Auchincloss, Hugh G., additional, Babic, Benjamin, additional, Baker, Talia B., additional, Ball, Chad G., additional, Barbetta, Arianna, additional, Barlow, John M., additional, Barr, Justin, additional, Barreto, Juan Camilo, additional, Barry, Linda, additional, Beal, Eliza W., additional, Beard, Kristin Wilson, additional, Beck, David E., additional, Behrns, Kevin E., additional, Bellevue, Oliver C., additional, Bellorin-Marin, Omar E., additional, Bergman, Jacques, additional, Berry, James, additional, Besselink, Marc G.H., additional, Bharucha, Adil E., additional, Bilchik, Anton J., additional, Bildzukewicz, Nikolai A., additional, Bingham, Jason, additional, Birnbaum, Elisa, additional, Black, Sylvester M., additional, Blackmon, Shanda H., additional, Bleier, Joshua I.S., additional, Bodzin, Adam S., additional, Boland, C. Richard, additional, Bolton, John, additional, Bolton, Nathan, additional, Bonavina, Luigi, additional, Bonds, Morgan, additional, Bouwense, Stefan A.W., additional, Boys, Joshua A., additional, Bravo-Infante, Raquel, additional, Bremner, Ross M., additional, Brenner, Bruce M., additional, Brown, Shaun R., additional, Callery, Mark P., additional, Cameron, John L., additional, Camilleri, Michael, additional, Campbell, Jacob, additional, Cassim, Riaz, additional, Castillo-Angeles, Manuel, additional, Cauley, Christy, additional, Cavaness, Keith M., additional, Cerfolio, Robert J., additional, Champagne, Bradley J., additional, Chandrasoma, Parakrama, additional, Chang, Alex L., additional, Chapman, Christopher G., additional, Chapman, William C., additional, Cheek, Susannah, additional, Chen, Harvey S., additional, Cho, Clifford S., additional, Choi, Eric T., additional, Choi, Eugene A., additional, Chojnacki, Karen A., additional, Choti, Michael A., additional, Christie, Ian, additional, Chua, Heidi, additional, Church, James M., additional, Cioffi, Jessica L., additional, Clark, Susannah, additional, Clavien, Pierre-Alain, additional, Cloud, Adam, additional, Colavita, Paul D., additional, Colquhoun, Steven D., additional, Conway, William, additional, Cools-Lartigue, Jonathan, additional, Coosemans, Willy, additional, Cornwell, Edward E., additional, Costantini, Mario, additional, Coyle, Yvonne, additional, Craig, Daniel A., additional, Croome, Kristopher P., additional, Cullen, Joseph J., additional, D'Andrea, Anthony P., additional, Dassopoulos, Themistocles, additional, Davila, Marta L., additional, Davila, Raquel E., additional, DeMeester, Steven R., additional, DeMeester, Tom R., additional, Dempsey, Daniel T., additional, dePrisco, Gregory, additional, Depypere, Lieven, additional, Dietz, David W., additional, Dillhoff, Mary E., additional, DiNorcia, Joseph, additional, Doane, Stephen M., additional, Dogeas, Epameinondas, additional, Dozois, Eric J., additional, Dumon, Kristoffel, additional, Dunn, Stephen P., additional, Dunst, Christy M., additional, Dussel, John N., additional, Dyer, Matthew, additional, Efron, Jonathan, additional, El-Gohary, Yousef, additional, Lakis, Mustapha El, additional, Ellison, E. Christopher, additional, Ellsmere, James, additional, Essani, Rahila, additional, Evans, Douglas B., additional, Fang, Sandy H., additional, Fasen, Geoffrey, additional, Fernando, Hiran C., additional, Ferri, Lorenzo, additional, Fichera, Alessandro, additional, Finck, Christine, additional, Fisher, Oliver M., additional, Fleshman, James W., additional, Fong, Yuman, additional, Foreman, Michael L., additional, Francone, Todd D., additional, Franko, Edward R., additional, French, Daniel, additional, Fuchs, Hans Friedrich, additional, Fuchs, Karl Hermann, additional, Funaki, Brian, additional, Funk, Geoffrey A., additional, Fusco, Joseph, additional, Gaitonde, Shrawan G., additional, Gajjar, Aakash H., additional, Garcia-Aguilar, Julio, additional, Gearhart, Susan, additional, Geller, David A., additional, Ghobadi, Comeron, additional, Gilbert, Sebastien, additional, Giles, David, additional, Gillaspie, Erin, additional, Girotti, Micah, additional, Gittes, George K., additional, Goodman, Michael D., additional, Gooszen, Hein G., additional, Gores, Gregory J., additional, Griffin, James F., additional, Griffin, S. Michael, additional, Grimm, Leander, additional, Grochola, L.F., additional, Habib, Fahim, additional, Hanks, John B., additional, Harris, James E., additional, Hartwig, Matthew G., additional, Hassan, Imran, additional, Hedrick, Traci L., additional, Hicks, Terry C., additional, Hodin, Richard, additional, Hofstetter, Wayne L., additional, Hogg, Melissa, additional, Hu, Yue-Yung, additional, Hungness, Eric S., additional, Hunt, Steven R., additional, Huseynova, Khumara, additional, Hyman, Neil H., additional, Iannitti, David A., additional, Indes, Jeffrey, additional, Jenkins, Megan, additional, Jensen, Todd, additional, Jeziorczak, Paul M., additional, Jilani, Danial, additional, Jiménez-Toscano, Marta, additional, Jobe, Blair A., additional, Johnston, Lily E., additional, Kahrilas, Peter J., additional, Kalady, Matthew F., additional, Kassira, Noor, additional, Katkhouda, Namir, additional, Katz, Philip O., additional, Keller, Deborah S., additional, Kelley, Matthew P., additional, Kennedy, Gregory D., additional, Kent, Tara Sotsky, additional, Kia, Leila, additional, Kibbe, Melina R., additional, Kim, John, additional, King, Alice, additional, Kiran, Ravi P., additional, Kirton, Orlando C., additional, Klein, Andrew, additional, Klein, Eric N., additional, Kohn, Geoffrey P., additional, Kovell, Robert Caleb, additional, Kozol, Robert, additional, Lacy, Antonio M., additional, Ladner, Daniela P., additional, Lagarde, S.M., additional, Laituri, Carrie A., additional, Landmann, Alessandra, additional, Lee, Janet T., additional, Lee, Lawrence L., additional, Leinicke, Jennifer A., additional, Lerut, Toni, additional, Levi, David M., additional, Li, Chao, additional, Liang, Yu, additional, Lichliter, Andrew H., additional, Lichliter, Warren E., additional, Lightner, Amy L., additional, Lile, Deacon J., additional, Lillemoe, Keith D., additional, Lin, Jules, additional, Lin, Shu S., additional, Lipham, John C., additional, Litle, Virginia R., additional, Lodhia, Nayna A., additional, Longo, Walter E., additional, Lord, Reginald V.N., additional, Louie, Brian E., additional, Low, Donald E., additional, Lowe, Val J., additional, Luc, Jessica G.Y., additional, Luketich, James D., additional, Ma, Yanling, additional, MacCarty, Robert L., additional, MacDonald, Blair, additional, Madoff, Robert D., additional, Magge, Deepa, additional, Maheshwari, Anurag, additional, Mahmoud, Najjia N., additional, Mahvi, David A., additional, Mahvi, David M., additional, Mak, Grace Z., additional, Mansfield, Sara A., additional, Manzano, Maricarmen, additional, Maron, David J., additional, Mathew, Melvy S., additional, Mathis, Kellie L., additional, Matthews, Jeffrey B., additional, McFadden, David W., additional, Merchea, Amit, additional, Messaris, Evangelos, additional, Miller, Daniel L., additional, Miller, Heidi J., additional, Millis, J. Michael, additional, Mittal, Sumeet K., additional, Molena, Daniela, additional, Montgomery, Stephanie C., additional, Moore, Ryan, additional, Morgan, Katherine A., additional, Mortenson, Melinda M., additional, Mulholland, Michael W., additional, Mulvihill, Michael S., additional, Mutch, Matthew, additional, Nafteux, Philippe Robert, additional, Nagaraju, Arun, additional, Nagorney, David M., additional, Nathan, Hari, additional, Natoli, Karen R., additional, Navuluri, Rakesh, additional, Nissen, Nicholas N., additional, Nobel, Tamar B., additional, Noordman, B.J., additional, Norton, Jeffrey A., additional, Novitsky, Yuri W., additional, Nussbaum, Michael S., additional, Nyberg, Scott L., additional, Oelschlager, Brant K., additional, Oh, Daniel S., additional, Otero-Piñeiro, Ana, additional, Oto, Aytekin, additional, Pachter, H. Leon, additional, Paidas, Charles N., additional, Palazzo, Francesco, additional, Paniccia, Alessandro, additional, Papaconstantinou, Harry T., additional, Pappas, Theodore N., additional, Pappou, Emmanouil P., additional, Parikh, Manish, additional, Paruch, Jennifer L., additional, Patel, Asish D., additional, Patel, Mikin, additional, Patti, Marco G., additional, Paulson, Emily Carter, additional, Pawlik, Timothy M., additional, Payne, Isaac, additional, Pemberton, John H., additional, Pendola, Michael, additional, Perez, Alexander, additional, Pernar, Luise I.M., additional, Peters, Walter R., additional, Petrowsky, Henrik, additional, Peyre, Christian G., additional, Phillips, Alexander W., additional, Pillai, Lashmikumar, additional, Plummer, Joseph M., additional, Pointer, David T., additional, Poruk, Katherine E., additional, Posner, Mitchell C., additional, Postier, Russell, additional, Prachand, Vivek N., additional, Pritts, Timothy A., additional, Quatrino, Gregory, additional, Ranka, Sagar, additional, Rattner, David W., additional, Reavis, Kevin M., additional, Reddy, Vikram B., additional, Remzi, Feza H., additional, Ricciardi, Rocco, additional, Rice, Thomas W., additional, Richman, Aaron, additional, Rider, Paul, additional, Roberts, John Paul, additional, Roberts, Patricia L., additional, Roggin, Kevin K., additional, Roll, Garrett Richard, additional, Rona, Kais, additional, Rosen, Charles B., additional, Ross, Samuel Wade, additional, Roth, J. Scott, additional, Rushing, Amy P., additional, Safar, Bashar, additional, Saldinger, Pierre F., additional, Samakar, Kamran, additional, Sandhu, Kulmeet K., additional, Schaheen, Lara W., additional, Schirmer, Bruce, additional, Schneider, Andrew, additional, Schulick, Richard D., additional, Schwab, Ben, additional, Scurci, Stephanie, additional, Senagore, Anthony, additional, Shah, Adil A., additional, Shah, Shimul A., additional, Shames, Brian, additional, Shanmugan, Skandan, additional, Shapiro, David S., additional, Silviera, Matthew, additional, Slakey, Douglas P., additional, Sloan, Joshua, additional, Smallwood, Nathan, additional, Smith, Shane P., additional, Smithers, B. Mark, additional, Smoot, Rory L., additional, Soares, Kevin C., additional, Soffer, Edy, additional, Solomina, Julia, additional, Soper, Nathaniel J., additional, Spechler, Stuart Jon, additional, Sridhar, Praveen, additional, Steele, Scott R., additional, Sternbach, Joel M., additional, Stevenson, Christina E., additional, Strong, Scott A., additional, Sucandy, Iswanto, additional, Sundaram, Magesh, additional, Sundaresan, Sudhir, additional, Swanstrom, Lee L., additional, Sylla, Patricia, additional, Takada, Tadahiro, additional, Talbot, Ethan, additional, Tam, Vernissia, additional, Tamm, Eric P., additional, Tatarian, Talar, additional, Tavakkoli, Ali, additional, Te, Helen S., additional, Teitelbaum, Ezra N., additional, Ternent, Charles A., additional, Thompson, Jon S., additional, Thomson, Iain, additional, Thorson, Alan G., additional, Thorson, Chad M., additional, Totten, Crystal F., additional, Truty, Mark J., additional, Tsai, Susan, additional, Tseng, Jennifer, additional, Tullius, Tom, additional, Tzakis, Andreas G., additional, van Lanschot, J.J.B., additional, van Santvoort, Hjalmar C., additional, Van Veer, Hans, additional, Vega, Jorge A., additional, Velanovich, Vic, additional, Vogler, Sarah A., additional, Wang, Huamin, additional, Ward, Mark A., additional, Warner, Brad W., additional, Warner, Susanne G., additional, Watson, Thomas J., additional, Waxman, Irving, additional, Webster-Lake, Carissa, additional, Wei, Benjamin, additional, Weiser, Martin R., additional, Wells, Dennis, additional, Wells, Katerina, additional, Welton, Mark Lane, additional, Wen, Yuxiang, additional, Wendling, Mark R., additional, Wesson, Hadley K.H., additional, Wexner, Steven D., additional, White, Rebekah R., additional, Whitlow, Charles B., additional, Wijnhoven, B.P.L., additional, Wilkes, Justin, additional, Wilson, Rickesha L., additional, Witkowski, Piotr, additional, Wolfgang, Christopher L., additional, Worrell, Stephanie G., additional, Yang, Jian, additional, Yeo, Charles J., additional, Yeung, Ching, additional, Yung, Evan E., additional, Zafar, Syed Nabeel, additional, Zaninotto, Giovanni, additional, Zeh, Herbert, additional, Zehetner, Joerg, additional, Zenilman, Michael E., additional, Zimmerman, Pamela, additional, and Zuccaro, Gregory, additional

Published
2019
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22. Controversy Over Liver Transplantation or Resection for Neuroendocrine Liver Metastasis

Author

Eshmuminov, Dilmurodjon, primary, Studer, Debora J., additional, Lopez Lopez, Victor, additional, Schneider, Marcel A., additional, Lerut, Jan, additional, Lo, Mary, additional, Sher, Linda, additional, Musholt, Thomas J., additional, Lozan, Oana, additional, Bouzakri, Nabila, additional, Sposito, Carlo, additional, Miceli, Rosalba, additional, Barat, Shoma, additional, Morris, David, additional, Oehler, Helga, additional, Schreckenbach, Teresa, additional, Husen, Peri, additional, Rosen, Charles B., additional, Gores, Gregory J., additional, Masui, Toshihiko, additional, Cheung, Tan-To, additional, Kim-Fuchs, Corina, additional, Perren, Aurel, additional, Dutkowski, Philipp, additional, Petrowsky, Henrik, additional, Thiis-Evensen, Espen, additional, Line, Pål-Dag, additional, Grat, Michal, additional, Partelli, Stefano, additional, Falconi, Massimo, additional, Tanno, Lulu, additional, Robles-Campos, Ricardo, additional, Mazzaferro, Vincenzo, additional, Clavien, Pierre-Alain, additional, and Lehmann, Kuno, additional

Published
2022
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29. Contributors

Author

Abou-Alfa, Ghassan K., primary, Abou Khalil, Jad, additional, Addeo, Pietro, additional, Adsay, N. Volkan, additional, Agarwal, Anil Kumar, additional, Alemi, Farzad, additional, Allen, Peter J., additional, Al-Mukhtar, Ahmed, additional, Aloia, Thomas A., additional, Andersen, Jesper B., additional, Anderson, Christopher D., additional, Arslan-Carlon, Vittoria, additional, Asbun, Horacio J., additional, Aussilhou, Béatrice, additional, Awad, Joseph, additional, Azoulay, Daniel, additional, Bachellier, Philippe, additional, Baker, Talia B., additional, Bamboat, Zubin M., additional, Barkun, Jeffrey Stewart, additional, Bassi, Claudio, additional, Basturk, Olca, additional, Beard, Rachel E., additional, Bedossa, Pierre, additional, Belghiti, Jacques, additional, Bellorin-Marin, Omar, additional, Besselink, Marc G.H., additional, Bilchik, Anton J., additional, Blumgart, Leslie H., additional, Boas, Franz Edward, additional, Brody, Lynn A., additional, Brown, Karen T., additional, Bruix, Jordi, additional, Bruno, David A., additional, Brunt, Elizabeth M., additional, Burns, Justin M., additional, Butturini, Giovanni, additional, Caicedo, Juan Carlos, additional, Callery, Mark P., additional, Calvino, Abdul Saied, additional, Carpenter, Danielle H., additional, Carter, C. Ross, additional, Cauchy, François, additional, Chan, Chung Yip, additional, Chan, See Ching, additional, Chapman, William C., additional, Cherqui, Daniel, additional, Cho, Clifford S., additional, Chung, Jin Wook, additional, Clanton, Jesse, additional, Clary, Bryan Marshall, additional, Cleary, Sean Patrick, additional, Collins, Kelly M., additional, Conneely, John Barry, additional, Connell, Louise C., additional, Corvera, Carlos U., additional, Costa, Guido, additional, Covey, Anne M., additional, Crippin, Jeffrey S., additional, Croome, Kristopher P., additional, Dabbous, Hany, additional, D'Angelica, Michael I., additional, Darcy, Michael D., additional, Davis, Jeremy L., additional, de Jonge, Jeroen, additional, DeMatteo, Ronald P., additional, DePeralta, Danielle K., additional, Desai, Niraj M., additional, de Santibañes, Eduardo, additional, de Santibañes, Martin, additional, Dickson, Euan J., additional, DiMaio, Christopher John, additional, Do, Richard Kinh Gian, additional, Dokmak, Safi, additional, Donati, Marcello, additional, Doyle, M.B. Majella, additional, Dudeja, Vikas, additional, Dunphy, Mark, additional, Earl, Truman M., additional, Ebata, Tomoki, additional, Dika, Imane El, additional, El-Gohary, Yousef, additional, Endo, Itaru, additional, Enestvedt, C. Kristian, additional, Espat, N. Joseph, additional, Ethun, Cecilia G., additional, Fan, Sheung Tat, additional, Fanta, Paul T., additional, Farges, Olivier, additional, Ferrone, Cristina R., additional, Fields, Ryan C., additional, Fischer, Mary, additional, Fisher, Sarah B., additional, Flaherty, Devin C., additional, Fong, Yuman, additional, Friedman, Scott L., additional, Gabr, Ahmed, additional, Galloway, John R., additional, Geller, David A., additional, Gerdes, Hans, additional, Gerst, Scott R., additional, Gittes, George K., additional, Glorioso, Jaime, additional, Gluskin, Jill S., additional, Goh, Brian K.P., additional, Gonzalez, Stevan A., additional, Goodman, Karyn A., additional, Gores, Gregory J., additional, Gotuzzo, Eduardo H., additional, Gouma, Dirk J., additional, Greig, Paul D., additional, Griffin, James F., additional, Halloran, Christopher M., additional, Halpern, Neil A., additional, Hammill, Chet W., additional, Hansen, Paul D., additional, Harding, James J., additional, M. Harrison, Ewen, additional, Hartwig, Werner, additional, Hasegawa, Kiyoshi, additional, Hechtman, Jaclyn F., additional, Heimbach, Julie K., additional, Helton, William S., additional, Hemming, Alan W., additional, Henderson, J. Michael, additional, Hirshberg, Asher, additional, Howe, James R., additional, Hughes, Christopher B., additional, Iacobuzio-Donahue, Christine, additional, Jarnagin, William R., additional, Jenkins, Roger L., additional, Jutric, Zeljka, additional, Kahlert, Christoph, additional, Kallini, Joseph Ralph, additional, Kangrga, Ivan, additional, Karanicolas, Paul J., additional, Katz, Seth S., additional, Katz, Steven C., additional, Kelly, Kaitlyn J., additional, Kemeny, Nancy E., additional, Kennedy, Eugene P., additional, Khalili, Korosh, additional, Khan, Adeel S., additional, Khan, Saboor, additional, Kim, Heung Bae, additional, Kingham, T. Peter, additional, Kirk, Allan D., additional, S. Klimstra, David, additional, Kluger, Michael, additional, Knechtle, Stuart J., additional, Koea, Jonathan B., additional, Kokudo, Norihiro, additional, Koliogiannis, Dionysios, additional, Kooby, David A., additional, Korenblat, Kevin, additional, Krebs, Simone, additional, LaQuaglia, Michael J., additional, LaQuaglia, Michael P., additional, LaRusso, Nicholas F., additional, Laurent, Alexis, additional, Lazaridis, Konstantinos N., additional, Leal, Julie N., additional, Lee, Eliza J., additional, Lee, Major Kenneth, additional, Lee, Ser Yee, additional, Lencioni, Riccardo, additional, Liccioni, Alexandre, additional, Lidsky, Michael E., additional, Lin, Chung-Wei, additional, Linehan, David C., additional, Lopez-Solis, Roberto Carlos, additional, Lowell, Jeffrey A., additional, Madoff, David C., additional, Maggi, Jason, additional, Maithel, Shishir K., additional, Majeed, Ali W., additional, Malfertheiner, Peter, additional, Malleo, Giuseppe, additional, Mao, Shennen A., additional, Marchegiani, Giovanni, additional, Marcos, Luis A., additional, Markmann, James F., additional, Marsh, J. Wallis, additional, Martin, Robert C.G., additional, Matsuyama, Ryusei, additional, Matter, Matthias S., additional, Mattera, Francisco Juan, additional, Maxwell, Jessica E., additional, Mazza, Oscar M., additional, McGilvray, Ian D., additional, McKay, Colin J., additional, McWeeney, Doireann M., additional, Melendez, Jose, additional, Mendelsohn, Robin B., additional, Miller, George, additional, Mönkemüller, Klaus E., additional, Mori, Ryutaro, additional, Moutinho, Vitor, additional, Nagino, Masato, additional, Nagorney, David M., additional, Nagula, Satish, additional, Nakeeb, Attila, additional, Nedredal, Geir I., additional, Neoptolemos, John P., additional, Neuberger, James, additional, Nyberg, Scott L., additional, O'Connor, Rachel, additional, O'Grady, John G., additional, Oldfield, Frances E., additional, Oldhafer, Karl J., additional, Olthoff, Kim M., additional, Orloff, Susan L., additional, Paniccia, Alessandro, additional, Paradis, Valérie, additional, Parks, Rowan W., additional, Pascal, Gérard, additional, Pastores, Stephen M., additional, Pawlik, Timothy M., additional, Pillarisetty, Venu G., additional, Pingpank, James Francis, additional, Pinson, C. Wright, additional, Pitt, Henry Anthony, additional, Pomposelli, James J., additional, Procopio, Fabio, additional, Pucci, Michael J., additional, Qadan, Motaz, additional, Rajkomar, Kheman, additional, Reddy, Srinevas K., additional, Reig, Maria E., additional, Reza, Joseph Arturo, additional, Roberts, John Paul, additional, Robson, Piera Marie Cote, additional, Rocha, Flavio G., additional, Roll, Garrett Richard, additional, Ronnekleiv-Kelly, Sean M., additional, Rosemurgy, Alexander S., additional, Rosen, Charles B., additional, Saldinger, Pierre F., additional, Salem, Riad, additional, Salem, Suhail Bakr, additional, Salvia, Roberto, additional, Sandroussi, Charbel, additional, Sanford, Dominic E., additional, Scatton, Olivier, additional, Schattner, Mark Andrew, additional, Schecter, William Palmer, additional, Schoellhammer, Hans Francis, additional, Schulick, Richard D., additional, Schwartz, Lawrence H., additional, Shah, Kevin N., additional, Shepherd, Ross W., additional, Shimada, Hiroshi, additional, Shimoda, Masafumi, additional, Shindoh, Junichi, additional, Shokouh-Amiri, Hosein, additional, Sicklick, Jason K., additional, Siegelbaum, Robert H., additional, Singh, Gagandeep, additional, Smoot, Rory L., additional, Solomon, Stephen B., additional, Soubrane, Olivier, additional, Spinelli, Nicholas, additional, Stauffer, John A., additional, Stewart, Lygia, additional, Strand, Matthew S., additional, Tabibian, James H., additional, Torzilli, Guido, additional, Trotter, James F., additional, Turcotte, Simon, additional, Turmelle, Yumirle P., additional, Tzimas, Demetrios J., additional, Van Gulik, Thomas, additional, Vannucci, Andrea, additional, Vauthey, Jean-Nicolas, additional, Vetter, Diana, additional, Vilgrain, Valérie, additional, Villamil, Alejandra Maria, additional, Voigt, Louis P., additional, Vollmer, Charles M., additional, Wands, Jack R., additional, Wattacheril, Julia, additional, Weber, Sharon Marie, additional, Weiss, Matthew J., additional, Weitz, Jürgen, additional, Werner, Jens, additional, Winner, Megan, additional, Wong, John, additional, Yang, Dennis, additional, Yarmohammadi, Hooman, additional, Yeo, Charles J., additional, Yeo, Theresa Pluth, additional, Yoon, Chang Jin, additional, Yopp, Adam, additional, Young, D. Owen, additional, Zhao, Kai, additional, Zibari, Gazi B., additional, and Zogopoulos, George, additional

Published
2017
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32. Controversy Over Liver Transplantation or Resection for Neuroendocrine Liver Metastasis: Tumor Biology Cuts the Deal.

Author

UCL - SSS/IREC - Institut de recherche expérimentale et clinique, Eshmuminov, Dilmurodjon, Studer, Debora J, Lopez Lopez, Victor, Schneider, Marcel André, Lerut, Jan, Lo, Mary, Sher, Linda, Musholt, Thomas Johannes, Lozan, Oana, Bouzakri, Nabila, Sposito, Carlo, Miceli, Rosalba, Barat, Shoma, Morris, David, Oehler, Helga, Schreckenbach, Teresa, Husen, Peri, Rosen, Charles B, Gores, Gregory J, Masui, Toshihiko, Cheung, Tan-To, Kim-Fuchs, Corina, Perren, Aurel, Dutkowski, Philipp, Petrowsky, Henrik, Thiis-Evensen, Espen, Line, Pål-Dag, Grat, Michal, Partelli, Stefano, Falconi, Massimo, Tanno, Lulu, Robles-Campos, Ricardo, Mazzaferro, Vincenzo, Clavien, Pierre-Alain, Lehmann, Kuno, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, Eshmuminov, Dilmurodjon, Studer, Debora J, Lopez Lopez, Victor, Schneider, Marcel André, Lerut, Jan, Lo, Mary, Sher, Linda, Musholt, Thomas Johannes, Lozan, Oana, Bouzakri, Nabila, Sposito, Carlo, Miceli, Rosalba, Barat, Shoma, Morris, David, Oehler, Helga, Schreckenbach, Teresa, Husen, Peri, Rosen, Charles B, Gores, Gregory J, Masui, Toshihiko, Cheung, Tan-To, Kim-Fuchs, Corina, Perren, Aurel, Dutkowski, Philipp, Petrowsky, Henrik, Thiis-Evensen, Espen, Line, Pål-Dag, Grat, Michal, Partelli, Stefano, Falconi, Massimo, Tanno, Lulu, Robles-Campos, Ricardo, Mazzaferro, Vincenzo, Clavien, Pierre-Alain, and Lehmann, Kuno

Abstract

In patients with neuroendocrine liver metastasis (NELM), liver transplantation (LT) is an alternative to liver resection (LR), although the choice of therapy remains controversial. In this multicenter study we aim to provide novel insight in this dispute. Following a systematic literature search, 15 large international centers were contacted to provide comprehensive data on their patients after LR or LT for NELM. Survival analyses were performed with the Kaplan-Meier method, while multivariable Cox regression served to identify factors influencing survival after either transplantation or resection. Inverse probability weighting (IPW) and propensity score matching was used for analyses with balanced and equalized baseline characteristics. Overall, 455 patients were analyzed, including 230 after LR and 225 after LT, with a median follow-up of 97 (95% CI 85-110) months. Multivariable analysis revealed G3 grading as a negative prognostic factor for LR (HR 2.22, 95%CI 1.04-4.77, P=0.040), while G2 grading (HR 2.52, 95%CI 1.15-5.52, P=0.021) and LT outside Milan criteria (HR 2.40, 95%CI 1.16-4.92, P=0.018) were negative prognostic factors in transplanted patients. IP-weighted multivariate analyses revealed a distinct survival benefit after LT. Matched patients presented a median overall survival (OS) of 197 months (95%CI 143- not reached) and a 73% 5-year OS after LT, and 119 months (95%CI 74-133) and a 52.8% 5-year OS after LR (HR 0.59, 95% CI 0.3- 0.9, P=0.022). However, the survival benefit after LT was lost if patients were transplanted outside Milan criteria. This multicentric study in patients with NELM demonstrates a survival benefit of LT over LR. This benefit depends on adherence to selection criteria, in particular low-grade tumor biology and Milan criteria, and must be balanced against potential risks of LT.

Published
2022

40. Induced Pluripotent Stem Cells From Subjects With Primary Sclerosing Cholangitis Develop a Senescence Phenotype Following Biliary Differentiation

Author

Jalan‐Sakrikar, Nidhi, primary, De Assuncao, Thiago M., additional, Navarro‐Corcuera, Amaia, additional, Hamdan, Feda H., additional, Loarca, Lorena, additional, Kirkeby, Lindsey A., additional, Resch, Zachary T., additional, O’Hara, Steven P., additional, Juran, Brian D., additional, Lazaridis, Konstantinos N., additional, Rosen, Charles B., additional, Heimbach, Julie K., additional, Taner, Timucin, additional, Shah, Vijay H., additional, LaRusso, Nicholas F., additional, and Huebert, Robert C., additional

Published
2021
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45. Endothelial nitric oxide synthase gene variation associated with chronic kidney disease after liver transplant

Author

Bambha, Kiran, Kim, W. Ray, Rosen, Charles B., Pedersen, Rachel A., Rys, Cynthia, Kolbert, Christopher P., Cunningham, Julie M., and Therneau, Terry M.

Subjects
Chronic kidney failure -- Genetic aspects -- Prevention -- Diagnosis -- Risk factors -- Care and treatment, Single nucleotide polymorphisms -- Risk factors -- Diagnosis -- Care and treatment -- Prevention -- Genetic aspects -- Health aspects, Liver -- Transplantation, Liver diseases -- Genetic aspects -- Risk factors -- Diagnosis -- Care and treatment -- Prevention
Abstract

OBJECTIVE: To identify single nucleotide polymorphisms (SNPs) associated with risk of developing chronic kidney disease (CKD), a prevalent comorbidity, after liver transplant (LT). PATIENTS AND METHODS: This study consists of [...]

Published
2010
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47. Early Cholangiocarcinoma Detection With Magnetic Resonance Imaging Versus Ultrasound in Primary Sclerosing Cholangitis

Author

Eaton, John E., primary, Welle, Christopher L., additional, Bakhshi, Zeinab, additional, Sheedy, Shannon P., additional, Idilman, Ilkay S., additional, Gores, Gregory J., additional, Rosen, Charles B., additional, Heimbach, Julie K., additional, Taner, Timucin, additional, Harnois, Denise M., additional, Lindor, Keith D., additional, LaRusso, Nicholas F., additional, Gossard, Andrea A., additional, Lazaridis, Konstantinos N., additional, and Venkatesh, Sudhakar K., additional

Published
2021
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48. Treatment options for hepatobiliary and pancreatic cancer

Author

Alberts, Steven R., Gores, Gregory J., Kim, George P., Roberts, Lewis R., Kendrick, Michael L., Rosen, Charles B., Chari, Suresh T., and Martenson, James A.

Subjects
Carcinoma -- Care and treatment, Carcinoma -- Diagnosis, Cancer -- Care and treatment, Cancer -- Diagnosis, Pancreatic cancer -- Care and treatment, Pancreatic cancer -- Diagnosis
Abstract

Hepatobiliary and pancreatic cancers account for 4% of all cancers in the United States. Traditionally, these cancers have had a high mortality rate and have been poorly responsive to therapy. [...]

Published
2007

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