295 results on '"Roseboom TJ"'
Search Results
2. Effects of tocolysis with nifedipine or atosiban on child outcome: follow‐up of the APOSTEL III trial
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Winden, Tms, Klumper, J, Kleinrouweler, Ce, Tichelaar, Ma, Naaktgeboren, Ca, Nijman, Ta, Baar, Al, Wassenaer‐leemhuis, Ag, Roseboom, Tj, Van’t Hooft, J, Roos, C, Mol, Bw, Pajkrt, E, Oudijk, Ma, Development and Treatment of Psychosocial Problems, Leerstoel Baar, Development and Treatment of Psychosocial Problems, Leerstoel Baar, Graduate School, Obstetrics and Gynaecology, APH - Methodology, Neonatology, Other Research, Epidemiology and Data Science, APH - Aging & Later Life, APH - Health Behaviors & Chronic Diseases, ARD - Amsterdam Reproduction and Development, APH - Personalized Medicine, APH - Quality of Care, Obstetrics and gynaecology, and Amsterdam Reproduction & Development (AR&D)
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Pediatrics ,medicine.medical_specialty ,medicine.medical_treatment ,preterm labour ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,Nifedipine ,law ,executivefunction ,follow-up ,Medicine ,Intubation ,development ,follow‐up ,child ,030219 obstetrics & reproductive medicine ,neurodevelopment ,business.industry ,Mortality rate ,Incidence (epidemiology) ,Atosiban ,General Obstetrics ,Obstetrics and Gynecology ,preterm birth ,health ,infant ,behaviour ,nifedipine ,executive function ,Neonatal outcomes ,tocolysis ,General health ,business ,medicine.drug - Abstract
Objective To compare the long‐term effects of tocolysis with nifedipine or atosiban on child outcome at age 2.5–5.5 years. Design The APOSTEL III trial was a multicentre randomised controlled trial that compared tocolysis with nifedipine or atosiban in 503 women with threatened preterm birth. Neonatal outcomes did not differ between both treatment arms, except for a higher incidence of intubation in the atosiban group. Methods Parents were asked to complete four questionnaires regarding neurodevelopment, executive function, behaviour problems and general health. Main outcome measures The main long‐term outcome measure was a composite of abnormal development at the age of 2.5–5.5 years. Results Of the 426 women eligible for follow‐up, 196 (46%) parents returned the questionnaires for 115 children in the nifedipine group and 110 children in the atosiban group. Abnormal development occurred in 32 children (30%) in the nifedipine group and in 38 children (38%) in the atosiban group (OR 0.74, 95% CI 0.41–1.34). The separate outcomes for neurodevelopment, executive function, behaviour, and general health showed no significant differences between the groups. Sensitivity analysis for all children of the APOSTEL III trial, including a comparison of deceased children, resulted in a higher rate of healthy survival in the nifedipine group (64 versus 54%), but there was no significant difference in the overall mortality rate (5.4 versus 2.7%). There were no significant subgroup effects. Conclusion Outcomes on broad child neurodevelopment, executive function, behaviour and general health were comparable in both groups. Neither nifedipine nor atosiban can be considered as the preferred treatment for women with threatened preterm birth. Tweetable abstract Nifedipine‐ and atosiban‐exposed children had comparable long‐term outcomes, including neurodevelopment, executive function and behaviour., Tweetable abstract Nifedipine‐ and atosiban‐exposed children had comparable long‐term outcomes, including neurodevelopment, executive function, and behaviour.
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- 2020
3. Effects of tocolysis with nifedipine or atosiban on child outcome: follow‐up of the APOSTEL III trial
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Development and Treatment of Psychosocial Problems, Leerstoel Baar, Winden, Tms, Klumper, J, Kleinrouweler, Ce, Tichelaar, Ma, Naaktgeboren, Ca, Nijman, Ta, Baar, Al, Wassenaer‐leemhuis, Ag, Roseboom, Tj, Van’t Hooft, J, Roos, C, Mol, Bw, Pajkrt, E, Oudijk, Ma, Development and Treatment of Psychosocial Problems, Leerstoel Baar, Winden, Tms, Klumper, J, Kleinrouweler, Ce, Tichelaar, Ma, Naaktgeboren, Ca, Nijman, Ta, Baar, Al, Wassenaer‐leemhuis, Ag, Roseboom, Tj, Van’t Hooft, J, Roos, C, Mol, Bw, Pajkrt, E, and Oudijk, Ma
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- 2020
4. Cognitive Behavioral Therapy for Antenatal Depression in a Pilot Randomized Controlled Trial and Effects on Neurobiological, Behavioral and Cognitive Outcomes in Offspring 3-7 Years Postpartum: A Perspective Article on Study Findings, Limitations and Future Aims
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Bleker, LS, Milgrom, J, Sexton-Oates, A, Parker, D, Roseboom, TJ, Gemmill, AW, Holt, CJ, Saffery, R, Connelly, A, Burger, H, De Rooij, SR, Bleker, LS, Milgrom, J, Sexton-Oates, A, Parker, D, Roseboom, TJ, Gemmill, AW, Holt, CJ, Saffery, R, Connelly, A, Burger, H, and De Rooij, SR
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PURPOSE OF ARTICLE: In a previous pilot randomized controlled trial including 54 pregnant women with depression, maternal mood improved after Cognitive Behavioural Therapy (CBT) compared to treatment as usual (TAU), showing medium to large effect sizes. The effect persisted up to 9 months postpartum, with infant outcomes also showing medium to large effects favoring CBT in various child domains. This perspective article summarizes the results of a follow-up that was performed approximately 5 years later in the same cohort, assessing the effects of antenatal Cognitive Behavioural Therapy for depression and anxiety on child buccal cell DNA-methylation, brain morphology, behavior and cognition. FINDINGS: Children from the CBT group had overall lower DNA-methylation compared to children from the TAU group. Mean DNA-methylation of all NR3C1 promoter-associated probes did not differ significantly between the CBT and TAU groups. Children from the CBT group had a thicker right lateral occipital cortex and lingual gyrus. In the CBT group, Voxel-Based-Morphometry analysis identified one cluster showing increased gray matter concentration in the right medial temporal lobe, and fixel-based analysis revealed reduced fiber-bundle-cross-section in the Fornix, the Optical Tract, and the Stria Terminalis. No differences were observed in full-scale IQ or Total Problems Score. When the total of hypotheses tests in this study was considered, differences in DNA-methylation and brain measurements were no longer significant. SUMMARY: Our explorative findings suggest that antenatal depression treatment decreases overall child DNA-methylation, increases cortical thickness, and decreases white matter fiber-bundle cross-section in regions involved in cognitive function and the stress response. Nevertheless, larger studies are warranted to confirm our preliminary conclusion that CBT in pregnancy alters neurobiological outcomes in children. Clinical relevance remains unclear as we found no effe
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- 2020
5. Long-term cardiometabolic disease risk in women with PCOS: A systematic review and meta-analysis
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Wekker, V, Van Dammen, L, Koning, Anton, Heida, KY, Painter, RC, Limpens, J (Jacqueline), Laven, Joop, Roeters van Lennep, Jeanine, Roseboom, TJ, van den Hoek, A, Wekker, V, Van Dammen, L, Koning, Anton, Heida, KY, Painter, RC, Limpens, J (Jacqueline), Laven, Joop, Roeters van Lennep, Jeanine, Roseboom, TJ, and van den Hoek, A
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- 2020
6. The long‐term effect of prenatal progesterone treatment on child development, behaviour and health: a systematic review
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Simons, NE, primary, Leeuw, M, additional, Hooft, J, additional, Limpens, J, additional, Roseboom, TJ, additional, Oudijk, MA, additional, Pajkrt, E, additional, Finken, MJJ, additional, and Painter, RC, additional
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- 2020
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7. Transgenerational effects of prenatal exposure to the 1944–45 Dutch famine
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Veenendaal, MVE, Painter, RC, de Rooij, SR, Bossuyt, PMM, van der Post, JAM, Gluckman, PD, Hanson, MA, and Roseboom, TJ
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- 2013
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8. A core outcome set for hyperemesis gravidarum research: an international consensus study
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Jansen, LAW, primary, Koot, MH, additional, van‘t Hooft, J, additional, Dean, CR, additional, Duffy, JMN, additional, Ganzevoort, W, additional, Gauw, N, additional, Goes, BY, additional, Rodenburg, J, additional, Roseboom, TJ, additional, Painter, RC, additional, and Grooten, IJ, additional
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- 2020
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9. Child outcomes after amnioinfusion compared with no intervention in women with second‐trimester rupture of membranes: a long‐term follow‐up study of the PROMEXIL‐III trial
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Ruigh, AA, primary, Simons, NE, additional, Hooft, J, additional, Teeffelen, AS, additional, Duijnhoven, RG, additional, Wassenaer‐Leemhuis, AG, additional, Aarnoudse‐Moens, C, additional, Beek, C, additional, Oepkes, D, additional, Haak, MC, additional, Woiski, M, additional, Porath, MM, additional, Derks, JB, additional, Kempen, LEM, additional, Roseboom, TJ, additional, Mol, BW, additional, and Pajkrt, E, additional
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- 2020
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10. Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life
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Painter, RC, Osmond, C, Gluckman, P, Hanson, M, Phillips, DIW, and Roseboom, TJ
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- 2008
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11. Brain Magnetic Resonance Imaging Findings in Children after Antenatal Maternal Depression Treatment, a Longitudinal Study Built on a Pilot Randomized Controlled Trial
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Bleker, LS, Milgrom, J, Parker, D, Gemmill, AW, Holt, CJ, Connelly, A, Burger, H, Roseboom, TJ, de Rooij, SR, Bleker, LS, Milgrom, J, Parker, D, Gemmill, AW, Holt, CJ, Connelly, A, Burger, H, Roseboom, TJ, and de Rooij, SR
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Antenatal depression is associated with an increased risk of offspring neuro-developmental disorders, potentially as a consequence of an altered brain development in utero. We hypothesized that reducing maternal depression by Cognitive Behavioral Therapy (CBT) during pregnancy may ameliorate the offspring's brain (micro)structural outcomes. 54 pregnant women with a diagnosed clinical depression were randomly allocated to CBT or Treatment as Usual (TAU), showing moderate to large depression symptom improvements after CBT. In 16 of their children (69% boys, N(TAU) = 8, N(CBT) = 8, mean age = 5.9 years, range = 3.9-7.1 years) brain Magnetic Resonance Imaging (MRI) scans were conducted. Children from the CBT group had a thicker right lateral occipital cortex (difference: 0.13 mm, 95% CI = 0.005-0.26) and lingual gyrus (difference: 0.18 mm, 95% CI = 0.01-0.34). In the CBT group, Voxel-Based Morphometry analysis identified one cluster showing increased gray matter concentration in the right medial temporal lobe at p < 0.05 uncorrected, and fixel-based analysis revealed reduced fiber-bundle cross-section in the Fornix, the Optical Tract, and the Stria Terminalis at p < 0.01 uncorrected. However, none of the results survived correction for multiple testing. Our explorative analyses provided some indication that antenatal CBT for depression may ameliorate offspring's brain (micro)structural outcomes, but the sample size was extremely small, and our results should be cautiously interpreted. Larger studies are warranted to confirm our preliminary conclusions that CBT for antenatal depression affects brain development in children.
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- 2019
12. A 7-year follow-up of antenatal depression treatment with cognitive behavioral therapy: A case report of maternal and child outcomes
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Bleker, LS, Milgrom, J, Gemmill, AW, Roseboom, TJ, de Rooij, SR, Bleker, LS, Milgrom, J, Gemmill, AW, Roseboom, TJ, and de Rooij, SR
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There are few studies of cognitive behavioral therapy for women with antenatal depression including qualitative and quantitative data, and yet, individual cases can provide valuable information on personal experiences of treatment effectiveness and acceptability. The purpose of this case report is to explore the long-term qualitative outcomes following cognitive behavioral therapy for antenatal depression. A pregnant woman with a Diagnostic and Statistical Manual of Mental Disorders diagnosis of depression was allocated to receive seven sessions of cognitive behavioral therapy in a randomized controlled trial. We describe her experiences and mood during treatment, at 12 weeks, 9 months, 2 years, and 7 years postpartum, as well as markers of her child's development. The woman's mood symptoms were dramatically improved after treatment and remained in the mild to moderate range until 7 years postpartum. Her child showed overall age-appropriate development, with strengths highlighted in his nonverbal and problem-solving ability. Relative weaknesses were in the communication domain and his processing speed. This case report suggests that psychological treatment for depression during pregnancy can be both acceptable to women and potentially protective in the long term.
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- 2019
13. The long‐term effect of prenatal progesterone treatment on child development, behaviour and health: a systematic review.
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Simons, NE, Leeuw, M, Hooft, J, Limpens, J, Roseboom, TJ, Oudijk, MA, Pajkrt, E, Finken, MJJ, and Painter, RC
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CHILD development ,PROGESTERONE ,HEALTH behavior ,PREMATURE labor ,RANDOMIZED controlled trials - Abstract
Background: Progesterone is widely used in prenatal care. However, long‐term effects of prenatal progesterone treatment on child development are unclear. Objectives: To evaluate long‐term outcomes in children after prenatal progesterone treatment. Search strategy: MEDLINE, Embase and Cochrane Central Register of Controlled Trials from inception to 24 May 2020. Selection criteria: Randomised controlled trials (RCTs) reporting outcomes in children born to women who received progesterone treatment (compared with placebo or another intervention) during any trimester in pregnancy. Data collection and analysis: Two authors independently selected and extracted data. We used the Cochrane Risk of Bias tool for randomised trials and Quality In Prognosis Studies. Main results: Of 388 papers, we included seven articles based on five RCTs, comprising 4222 measurements of children aged 6 months to 8 years. All studies compared progesterone to placebo in second and/or third trimester for the prevention of preterm birth. Meta‐analysis (two studies, n = 890 children) showed no difference in neurodevelopment as assessed by the Bayley‐III Cognitive Composite score at 2 years between children exposed to progesterone versus placebo (Standardised Mean Difference −0.04, 95% Confidence Interval −0.26 to 0.19), I2 = 22%. Heterogeneity prohibited additional meta‐analyses. Other long‐term outcomes showed no differences. Conclusions: Our systematic review comprising a multitude of developmental measurements with a broad age range did not find evidence of benefit or harm in offspring prenatally exposed to progesterone treatment for the prevention of preterm birth. We identified an urgent need for follow‐up studies of prenatal progesterone administration in early pregnancy and effects in offspring beyond early childhood. Progesterone to prevent preterm birth: no effect on child development. Outcomes after first trimester progesterone are unclear. Progesterone to prevent preterm birth: no effect on child development. Outcomes after first trimester progesterone are unclear. [ABSTRACT FROM AUTHOR]
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- 2021
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14. Child outcomes after amnioinfusion compared with no intervention in women with second-trimester rupture of membranes: a long-term follow-up study of the PROMEXIL-III trial.
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Ruigh, AA, Simons, NE, Hooft, J, Teeffelen, AS, Duijnhoven, RG, Wassenaer‐Leemhuis, AG, Aarnoudse‐Moens, C, Beek, C, Oepkes, D, Haak, MC, Woiski, M, Porath, MM, Derks, JB, Kempen, LEM, Roseboom, TJ, Mol, BW, Pajkrt, E, de Ruigh, A A, Simons, N E, and van 't Hooft, J
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TODDLERS development ,INFANT development ,RANDOMIZED controlled trials ,ODDS ratio ,STANDARD deviations ,RESPIRATORY diseases ,RESEARCH ,AGE distribution ,RESEARCH methodology ,AMNIOTIC liquid ,MEDICAL cooperation ,EVALUATION research ,PARENTERAL infusions ,COMPARATIVE studies ,PREGNANCY complications ,SECOND trimester of pregnancy ,LONGITUDINAL method ,INTELLIGENCE tests - Abstract
Objective: To assess the effect of transabdominal amnioinfusion or no intervention on long-term outcomes in children born after second-trimester prelabour rupture of the membranes (PROM between 16+0/7 -24+0/7 weeks) and oligohydramnios.Population: Follow up of infants of women who participated in the randomised controlled trial: PPROMEXIL-III (NTR3492).Methods: Surviving infants were invited for neurodevelopmental assessment up to 5 years of corrected age using a Bayley Scales of Infant and Toddler Development or a Wechsler Preschool and Primary Scale of Intelligence. Parents were asked to complete several questionnaires.Main Outcome Measures: Neurodevelopmental outcomes were measured. Mild delay was defined as -1 standard deviation (SD), severe delay as -2 SD. Healthy long-term survival was defined as survival without neurodevelopmental delay or respiratory problems.Results: In the amnioinfusion group, 18/28 children (64%) died versus 21/28 (75%) in the no intervention group (relative risk 0.86; 95% confidence interval [CI] 0.60-1.22). Follow-up data were obtained from 14/17 (82%) children (10 amnioinfusion, 4 no intervention). In both groups, 2/28 (7.1%) had a mild neurodevelopmental delay. No severe delay was seen. Healthy long-term survival occurred in 5/28 children (17.9%) after amnioinfusion versus 2/28 (7.1%) after no intervention (odds ratio 2.50; 95% CI 0.53-11.83). When analysing data for all assessed survivors, 10/14 (71.4%) survived without mild neurodevelopmental delay and 7/14 (50%) were classified healthy long-term survivor.Conclusions: In this small sample of women suffering second-trimester PROM and oligohydramnios, amnioinfusion did not improve long-term outcomes. Overall, 71% of survivors had no neurodevelopmental delay.Tweetable Abstract: Healthy long-term survival was comparable for children born after second-trimester PROM and treatment with amnioinfusion or no intervention. [ABSTRACT FROM AUTHOR]- Published
- 2021
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15. Variation in hyperemesis gravidarum definition and outcome reporting in randomised clinical trials: a systematic review
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Koot, MH, primary, Boelig, RC, additional, van‘t Hooft, J, additional, Limpens, J, additional, Roseboom, TJ, additional, Painter, RC, additional, and Grooten, IJ, additional
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- 2018
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16. Hyperemesis gravidarum and cardiometabolic risk factors in adolescents: a follow-up of the Northern Finland Birth Cohort 1986
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Koot, MH, primary, Grooten, IJ, additional, Sebert, S, additional, Koiranen, M, additional, Järvelin, MR, additional, Kajantie, E, additional, Painter, RC, additional, and Roseboom, TJ, additional
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- 2017
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17. Early nasogastric tube feeding in optimising treatment for hyperemesis gravidarum: the MOTHER randomised controlled trial (Maternal and Offspring outcomes after Treatment of HyperEmesis by Refeeding)
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Grooten, IJ, Mol, BW, van der Post, JAM, Ris-Stalpers, C, Kok, M, Bais, JMJ, Bax, CJ, Duvekot, J.J., Bremer, HA, Porath, MM, Heidema, WM, Bloemenkamp, KWM, Scheepers, HCJ, Franssen, MTM, Oudijk, MA, Roseboom, TJ, Painter, RC, Grooten, IJ, Mol, BW, van der Post, JAM, Ris-Stalpers, C, Kok, M, Bais, JMJ, Bax, CJ, Duvekot, J.J., Bremer, HA, Porath, MM, Heidema, WM, Bloemenkamp, KWM, Scheepers, HCJ, Franssen, MTM, Oudijk, MA, Roseboom, TJ, and Painter, RC
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Background: Hyperemesis gravidarum (HG), or intractable vomiting during pregnancy, is the single most frequent cause of hospital admission in early pregnancy. HG has a major impact on maternal quality of life and has repeatedly been associated with poor pregnancy outcome such as low birth weight. Currently, women with HG are admitted to hospital for intravenous fluid replacement, without receiving specific nutritional attention. Nasogastric tube feeding is sometimes used as last resort treatment. At present no randomised trials on dietary or rehydration interventions have been performed. Small observational studies indicate that enteral tube feeding may have the ability to effectively treat dehydration and malnutrition and alleviate nausea and vomiting symptoms. We aim to evaluate the effectiveness of early enteral tube feeding in addition to standard care on nausea and vomiting symptoms and pregnancy outcomes in HG patients. Methods/Design: The MOTHER trial is a multicentre open label randomised controlled trial (www.studies-obsgyn.nl/mother). Women >= 18 years hospitalised for HG between 5 + 0 and 19 + 6 weeks gestation are eligible for participation. After informed consent participants are randomly allocated to standard care with intravenous rehydration or early enteral tube feeding in addition to standard care. All women keep a weekly diary to record symptoms and dietary intake until 20 weeks gestation. The primary outcome will be neonatal birth weight. Secondary outcomes will be the 24-h Pregnancy Unique Quantification of Emesis and nausea score (PUQE-24), maternal weight gain, dietary intake, duration of hospital stay, number of readmissions, quality of life and side-effects. Also gestational age at birth, placental weight, umbilical cord plasma lipid concentration and neonatal morbidity will be evaluated. Analysis will be according to the intention to treat principle. Discussion: With this trial we aim to clarify whether early enteral tube feeding is more eff
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- 2016
18. Vitamin B12and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5-6 years: findings from the ABCD multi-ethnic birth cohort
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Krikke, GG, primary, Grooten, IJ, additional, Vrijkotte, TGM, additional, van Eijsden, M, additional, Roseboom, TJ, additional, and Painter, RC, additional
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- 2015
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19. Weight loss in pregnancy and cardiometabolic profile in childhood: findings from a longitudinal birth cohort
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Grooten, IJ, primary, Painter, RC, additional, Pontesilli, M, additional, van der Post, JAM, additional, Mol, BWJ, additional, van Eijsden, M, additional, Vrijkotte, TGM, additional, and Roseboom, TJ, additional
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- 2014
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20. Vitamin B12 and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5-6 years: findings from the ABCD multi-ethnic birth cohort.
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Krikke, GG, Grooten, IJ, Vrijkotte, TGM, Eijsden, M, Roseboom, TJ, and Painter, RC
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NUTRITION in pregnancy ,VITAMIN B12 ,FOLIC acid in human nutrition ,HEART metabolism ,GESTATIONAL age ,HEART beat ,CHILDREN'S health ,PREGNANT women ,HEART disease epidemiology ,VITAMIN deficiency ,ETHNIC groups ,FOLIC acid ,FOLIC acid deficiency ,LONGITUDINAL method ,METABOLIC disorders ,PREGNANCY complications - Abstract
Objective: To explore whether maternal vitamin B12 and folate status during early pregnancy are associated with cardiometabolic risk factors in the offspring at age 5-6.Design: Prospective multi-ethnic birth cohort, the Amsterdam Born Children and their Development study (ABCD).Setting: 12,373 pregnant women living in Amsterdam were approached between 2003 and 2004 for participation in the study.Population: Mother-child pairs for whom information on maternal vitamin B12 or folate status in early gestation and health at age 5-6 years was available (n = 1950).Methods: Vitamin B12 and folate concentrations were determined in maternal serum at intake in early pregnancy (median 13 weeks' gestation). Anthropometric measurements, blood pressure and fasting blood samples were collected during a health check of children aged 5-6 years. Multiple linear regression was performed to investigate the association between maternal serum concentrations and children's outcomes, corrected for confounders.Main Outcome Measures: Gestational age at birth, birthweight, body mass index (BMI), glucose levels, triglyceride levels, blood pressure and heart rate of the offspring at age 5-6.Results: Low maternal folate levels during early pregnancy were associated with slightly higher BMI in the offspring [decrease per 10 units: β 0.07 kg/m(2), 95% confidence interval (CI) 0.01, 0.13]. Low maternal vitamin B12 concentrations were associated with higher heart rates (decrease per 100 units: β 0.49 beats/min, 95% CI 0.11, 0.87).Conclusion: This study provides further evidence that maternal nutrition in early pregnancy may possibly program cardiometabolic health of the offspring.Tweetable Abstract: Low folate and vitamin B12 levels during pregnancy are associated with higher BMI and heart rate in offspring. [ABSTRACT FROM AUTHOR]- Published
- 2016
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21. Weight loss in pregnancy and cardiometabolic profile in childhood: findings from a longitudinal birth cohort.
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Grooten, IJ, Painter, RC, Pontesilli, M, Post, JAM, Mol, BWJ, Eijsden, M, Vrijkotte, TGM, and Roseboom, TJ
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Objective: To investigate the consequences of weight loss in pregnancy on pregnancy outcomes and cardiometabolic profile in childhood.Design: Prospective birth cohort (ABCD study).Setting: Between 2003 and 2004, all pregnant women in Amsterdam were approached for study participation.Population: 7818 pregnant women were included, of which 3165 consented to having their children examined at 5-6 years of age. In 1956 children fasting capillary blood samples were also taken.Methods: At antenatal booking, women answered questions about their pregnancy and whether they suffered from severe weight loss (SWL; >5 kg). Pregnancy details and outcomes were available through the obstetric caregiver.Main Outcome Measures: At birth main outcome measures were prematurity (<37 weeks) and birthweight. At follow-up, body mass index (BMI), blood pressure, glucose and lipids were assessed.Results: SWL occurred in 6.8% of cases. Women with SWL had similar preterm birth rates compared with women without these complaints (adjusted OR 1.1, 95%CI 0.7, 1.7). Birthweight (adjusted difference - 31 g, 95%CI -76, 15) and BMI at 5-6 years of age (adjusted difference 0.2 kg/m(2) , 95%CI 0.0, 0.5) were similar in children born to mothers with SWL and without SWL, but blood pressure was increased. For diastolic blood pressure this association was independent of confounders (adjusted difference 1.4 mmHg, 95%CI 0.4, 2.4). Lipid and glucose levels were not significantly different between these groups.Conclusion: Early pregnancy weight loss, usually occurring as a manifestation of hyperemesis gravidarum, could have long-term consequences for offspring health. [ABSTRACT FROM AUTHOR]- Published
- 2015
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22. Consequences of hyperemesis gravidarum for offspring: a systematic review and meta-analysis
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Veenendaal, MVE, primary, van Abeelen, AFM, additional, Painter, RC, additional, van der Post, JAM, additional, and Roseboom, TJ, additional
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- 2011
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23. Glucose tolerance in adults after prenatal exposure to famine
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Bleker, OP, primary, van der Meulen, JHP, additional, Ravelli, ACJ, additional, Roseboom, TJ, additional, Michels, RPJ, additional, Barker, DJP, additional, Hales, CN, additional, and Osmond, C, additional
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- 2001
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24. The fetal origins of hypertension: a systematic review and meta-analysis of the evidence from animal experiments of maternal undernutrition.
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Van Abeelen AF, Veenendaal MV, Painter RC, De Rooij SR, Thangaratinam S, Van Der Post JA, Bossuyt PM, Elias SG, Uiterwaal CS, Grobbee DE, Saade GR, Mol BW, Khan KS, and Roseboom TJ
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- 2012
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25. Cardiovascular and cortisol reactions to acute psychological stress and adiposity: cross-sectional and prospective associations in the dutch famine birth cohort study.
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Phillips AC, Roseboom TJ, Carroll D, and de Rooij SR
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- 2012
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26. Maternal pre-pregnancy body mass index explains infant's weight and BMI at 14 months: results from a multi-ethnic birth cohort study.
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Mesman I, Roseboom TJ, Bonsel GJ, Gemke RJ, van der Wal MF, and Vrijkotte TG
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OBJECTIVE: To investigate the association between (self-reported) maternal pre-pregnancy body mass index (pBMI), and child's weight, height and BMI at age 14 months. DESIGN: Prospective multi-ethnic community-based cohort study. SETTING: Amsterdam, The Netherlands. PARTICIPANTS: 8266 pregnant women from the Amsterdam Born Children and their Development study, filled out a questionnaire covering socio-demographic data, obstetric history, lifestyle, dietary habits and psychosocial factors, 2 weeks after their first antenatal visit. 7730 gave birth to a viable term singleton infant with information on birth weight, gender and pregnancy duration. Growth data were available for 3171 of these children. MAIN OUTCOME MEASURES: Weight (g), height (cm) and BMI (kg/m(2)) of the child at age 14 months. RESULTS: pBMI was linearly associated with weight and BMI of the child at age 14 months. One unit increase in pBMI resulted in an increment of 29 g (95% CI 19 to 39) in weight and 0.041 kg/m(2) (95% CI 0.030 to 0.053) in BMI. The effect size decreased after adjustment for birth weight (weight: beta coefficient 19 g, 95% CI 10 to 28; BMI: beta coefficient 0.034 kg/m(2), 95% CI 0.023 to 0.046) and hardly changed after adjustment for all other variables (weight: beta coefficient 21 g, 95% CI 11 to 30; BMI: beta coefficient 0.031 kg/m(2), 95% CI 0.019 to 0.043). pBMI was not related to height. CONCLUSIONS: pBMI is an independent determinant of weight and BMI of the child at age 14 months. At least one third of this effect is mediated through birth weight. [ABSTRACT FROM AUTHOR]
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- 2009
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27. Maternal nutrition during gestation and carotid arterial compliance in the adult offspring: the Dutch famine birth cohort.
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Painter RC, de Rooij SR, Bossuyt PM, de Groot E, Stok WJ, Osmond C, Barker DJ, Bleker OP, and Roseboom TJ
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- 2007
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28. Blood pressure response to psychological stressors in adults after prenatal exposure to the Dutch famine.
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Painter RC, de Rooij SR, Bossuyt PM, Phillips DI, Osmond C, Barker DJ, Bleker OP, and Roseboom TJ
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- 2006
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29. The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on glucose/insulin metabolism interact with prenatal exposure to famine.
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de Rooij SR, Painter RC, Phillips DIW, Osmond C, Tanck MWT, Defesche JC, Bossuyt PMM, Michels RPJ, Bleker OP, Roseboom TJ, de Rooij, Susanne R, Painter, Rebecca C, Phillips, David I W, Osmond, Clive, Tanck, Michael W T, Defesche, Joep C, Bossuyt, Patrick M M, Michels, Robert P J, Bleker, Otto P, and Roseboom, Tessa J
- Abstract
Objective: An adverse fetal environment may permanently modify the effects of specific genes on glucose tolerance, insulin secretion, and insulin sensitivity. In the present study, we assessed a possible interaction of the peroxisome proliferator-activated receptor (PPAR)-gamma2 Pro12Ala polymorphism with prenatal exposure to famine on glucose and insulin metabolism.Research Design and Methods: We measured plasma glucose and insulin concentrations after an oral glucose tolerance test and determined the PPAR-gamma2 genotype among 675 term singletons born around the time of the 1944-1945 Dutch famine.Results: A significant interaction effect between exposure to famine during midgestation and the PPAR-gamma2 Pro12Ala polymorphism was found on the prevalence of impaired glucose tolerance and type 2 diabetes. The Ala allele of the PPAR-gamma2 gene was associated with a higher prevalence of impaired glucose tolerance and type 2 diabetes but only in participants who had been prenatally exposed to famine during midgestation. Similar interactions were found for area under the curve for insulin and insulin increment ratio, which were lower for Ala carriers exposed to famine during midgestation.Conclusions: The effects of the PPAR-gamma2 Pro12Ala polymorphism on glucose and insulin metabolism may be modified by prenatal exposure to famine during midgestation. This is possibly due to a combined deficit in insulin secretion, as conferred by pancreatic beta-cell maldevelopment and carrier type of the Ala allele in the PPAR-gamma2 gene. [ABSTRACT FROM AUTHOR]- Published
- 2006
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30. Maternal nutrition during gestation and blood pressure in later life.
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Roseboom TJ, van der Meulen JHP, van Montfrans GA, Ravelli ACJ, Osmond C, Barker DJP, Bleker OP, Roseboom, T J, van der Meulen, J H, van Montfrans, G A, Ravelli, A C, Osmond, C, Barker, D J, and Bleker, O P
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- 2001
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31. Blood pressure in adults after prenatal exposure to famine.
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Roseboom TJ, van der Meulen JH, Ravelli AC, van Montfrans GA, Osmond C, Barker DJ, Bleker OP, Roseboom, T J, van der Meulen, J H, Ravelli, A C, van Montfrans, G A, Osmond, C, Barker, D J, and Bleker, O P
- Published
- 1999
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32. Variants in the SIRT1 gene may affect diabetes risk in interaction with prenatal exposure to famine.
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Botden IP, Zillikens MC, de Rooij SR, Langendonk JG, Danser AH, Sijbrands EJ, Roseboom TJ, Botden, Ilse P G, Zillikens, M Carola, de Rooij, Susanne R, Langendonk, Janneke G, Danser, A H Jan, Sijbrands, Eric J G, and Roseboom, Tessa J
- Abstract
Objective: To investigate whether SIRT1, a nutrient-sensing histone deacetylase, influences fetal programming during malnutrition.Research Design and Methods: In 793 individuals of the Dutch Famine Birth Cohort, we analyzed the interaction between three SIRT1 single nucleotide polymorphisms (SNPs) and prenatal exposure to famine on type 2 diabetes risk.Results: In the total population (exposed and unexposed), SIRT1 variants were not associated with type 2 diabetes. A significant interaction was found between two SIRT1 SNPs and exposure to famine in utero on type 2 diabetes risk (P = 0.03 for rs7895833; P = 0.01 for rs1467568). Minor alleles of these SNPs were associated with a lower prevalence of type 2 diabetes only in individuals who had been exposed to famine prenatally (odds ratio for rs7895833 0.50 [95% CI 0.24-1.03], P = 0.06; for rs1467568 0.48 [0.25-0.91], P = 0.02).Conclusions: SIRT1 may be an important genetic factor involved in fetal programming during malnutrition, influencing type 2 diabetes risk later in life. [ABSTRACT FROM AUTHOR]- Published
- 2012
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33. Undernutrition during fetal life and the risk of cardiovascular disease in adulthood.
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Roseboom TJ
- Published
- 2012
34. Maternal obesity in pregnancy impacts offspring cardiometabolic health: Systematic review and meta-analysis of animal studies
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Menting, MD, Mintjens, S, Van De Beek, C, Frick, CJ, Ozanne, SE, Limpens, J, Roseboom, TJ, Hooijmans, CR, Van Deutekom, AW, and Painter, RC
- Subjects
2. Zero hunger ,Obesity, Maternal ,Pregnancy Complications ,obesity ,systematic review ,Pregnancy ,Prenatal Exposure Delayed Effects ,Cardiometabolic health ,Animals ,Female ,3. Good health ,Body Mass Index - Abstract
Obesity before and during pregnancy leads to reduced offspring cardiometabolic health. Here, we systematically reviewed animal experimental evidence of maternal obesity before and during pregnancy and offspring anthropometry and cardiometabolic health. We systematically searched Embase and Medline from inception until January 2018. Eligible publications compared offspring of mothers with obesity to mothers with a normal weight. We performed meta-analyses and subgroup analyses. We also examined methodological quality and publication bias. We screened 2543 publications and included 145 publications (N = 21 048 animals, five species). Essential methodological details were not reported in the majority of studies. We found evidence of publication bias for birth weight. Offspring of mothers with obesity had higher body weight (standardized mean difference (SMD) 0.76 [95% CI 0.60;0.93]), fat percentage (0.99 [0.64;1.35]), systolic blood pressure (1.33 [0.75;1.91]), triglycerides (0.64 [0.42;0.86], total cholesterol (0.46 [0.18;0.73]), glucose level (0.43 [0.24;0.63]), and insulin level (0.81 [0.61;1.02]) than offspring of control mothers, but similar birth weight. Sex, age, or species did not influence the effect of maternal obesity on offspring's cardiometabolic health. Obesity before and during pregnancy reduces offspring cardiometabolic health in animals. Future intervention studies should investigate whether reducing obesity prior to conception could prevent these detrimental programming effects and improve cardiometabolic health of future generations.
35. Early Life Nutrition, Growth and Kidney Function in Children : The Generation R Study
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Miliku, K, Jaddoe, Vincent, Roseboom, TJ, Raat, Hein, Zietse, R., Epidemiology, and Pediatrics
- Published
- 2017
36. Long-term effects of unintended pregnancy on children: Findings from the Dutch prospective birth-cohort Amsterdam born children and their development study.
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Beumer WY, Koot MH, Vrijkotte T, Roseboom TJ, and van Ditzhuijzen J
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- Humans, Female, Pregnancy, Netherlands epidemiology, Adolescent, Child, Prospective Studies, Longitudinal Studies, Male, Birth Cohort, Child, Preschool, Surveys and Questionnaires, Adult, Pregnancy, Unplanned psychology
- Abstract
Several studies investigated short-term risks of children born from unintended pregnancies, however evidence about long-term risks is lacking. We aimed to examine whether children born from unintended pregnancies experience psychosocial problems up into adolescence. This study is based on the longitudinal birth cohort study 'Amsterdam Born Children and their Development' (n = 7784). Unintended pregnancy was measured as a multidimensional construct, based on self-reports on the extent of pregnancy mistiming ('This pregnancy happened too soon'), unwantedness ('I did not want to be pregnant (anymore)') and unhappiness ('I am happy to be pregnant'; recoded). Further, children's psychosocial problems were measured with the Strengths and Difficulties Questionnaire, at 5-6, 11-12 and 15-16 years old. Multiple over-time associations between unintended pregnancy and children's psychosocial problems were analysed using Structural Equation Modelling, while controlling for confounders. Results showed that pregnancy mistiming was a significant predictor of internalizing (β = 0.10, p < 0.001) and externalizing problems (β = 0.07, p = 0.006) and unwanted pregnancy of internalizing problems (β = 0.13, p < 0.001) at 5-6 years. These associations were substantially mediated by maternal mental health and poorer maternal bonding. Associations were no longer present at 11-12 and 15-16 years. Thus, we conclude that children born from unintended pregnancies experience more psychosocial problems at 5-6 years, but no longer at 11-12 and 15-16 years. Unintended pregnancies often coincide with maternal mental health problems and socioeconomic factors. Most importantly, the associations between unintended pregnancy and children's psychosocial problems are influenced by maternal mental health and poorer bonding. Therefore it is important to improve maternal mental health and bonding for the benefit of both mother and child, rather than on the isolated effect of unintended pregnancy per se., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2024
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37. Neurodevelopmental outcomes of school-age children conceived after hysterosalpingography with oil-based or water-based iodinated contrast: long-term follow-up of a nationwide randomized controlled trial.
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Keestra SM, Van Welie N, Dreyer K, Van Eekelen R, Roseboom TJ, Oosterlaan J, Mol BW, Finken MJJ, Mijatovic V, and Königs M
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Study Question: Does preconceptional exposure to oil-based iodinated contrast media during hysterosalpingography (HSG) impact children's neurodevelopment compared with exposure to water-based alternatives?, Summary Answer: Our study found no large-sized effects for neurodevelopment in children with preconceptional exposure to oil-based iodinated contrast media during HSG compared with water-based alternatives., What Is Known Already: HSG is widely used as a diagnostic tool in the female fertility work-up. Tubal flushing with oil-based iodinated contrast has been shown to enhance fertility outcomes in couples with unexplained infertility, increasing the chances of pregnancy and live birth compared with water-based alternatives. However, oil-based contrast contains higher doses of iodine and has a longer half-life, and concerns exist that iodinated contrast media can affect women's iodine status and cause temporary (sub)clinical hypothyroidism in mothers and/or foetuses. Considering that thyroid hormones are vital to embryonal and foetal brain development, oil-based contrast media use could increase the risk of impaired neurodevelopment in children conceived shortly after HSG. Here we examine neurodevelopmental outcomes in school-aged children conceived after HSG., Study Design, Size, Duration: This is a long-term follow-up of the H2Oil trial in which oil-based or water-based contrast was used during HSG (Netherlands; 2012-2014; NTR3270). Of 369 children born <6 months after HSG in the study, we contacted the mothers of 140 children who gave consent to be contacted for follow-up. The follow-up study took place from January to July 2022 (NCT05168228)., Participants/materials, Settings, Methods: The study included 69 children aged 6-9 years who were conceived after HSG with oil-based (n = 42) or water-based contrast (n = 27). The assessments targeted intelligence (Wechsler Intelligence Scale for Children), neurocognitive outcomes (computerized neurocognitive tests), behavioural functioning (parent and teacher questionnaires), and academic performance. Linear regression models, adjusted for age, sex, and parental educational attainment were employed to compare groups., Main Results and the Role of Chance: School-aged children born to mothers after oil-based contrast HSG did not significantly differ from children born to mothers after water-based contrast HSG, in regards to intelligence, neurocognitive functioning, behavioural functioning, or academic performance, with the exception of better performance for visuomotor integration functions in children exposed to oil-based contrast preconception. After exploratory correction for multiple comparisons, none of the group differences was statistically significant., Limitations, Reasons for Caution: The small sample size of this follow-up study limited statistical power. This study provides evidence for the absence of large-sized differences between preconceptional exposure to the two contrast media types but does not rule out more subtle effects on neurodevelopment compared to naturally conceived children without preconceptional exposure to HSG., Wider Implications of the Findings: This study contributes to our knowledge about the long-term effects of different types of iodinated contrast media used in fertility work-up, indicating that choosing oil-based over water-based iodinated contrast media is unlikely to have major effect on the long-term neurodevelopmental outcomes of children conceived shortly after HSG. However, further research should focus on the overall safety of iodine exposure during HSG, comparing children conceived after HSG to those conceived naturally as both types of contrast contain high amounts of iodine., Study Funding/competing Interest(s): The original H2Oil randomized controlled trial was an investigator-initiated study that was funded by the two academic hospitals now merged into the Amsterdam University Medical Centre. The current follow-up study (Neuro-H2Oil) is funded through a research grant awarded to the authors by the Amsterdam Reproduction & Development (AR&D) research institute. S.K. is funded by a AMC MD/PhD Scholarship from the Amsterdam UMC. S.K. reports holding voluntary roles in the civil society organizations Universities Allied for Essential Medicines and People's Health Movement. V.M. reports receiving travel and speaker fees as well as research grants from Guerbet, Merck and Ferring. K.D. reports receiving travel and speaker fees as well as research grants from Guerbet. BWM is supported by a NHMRC Investigator grant (GNT1176437) and reports consultancy, travel support and research funding from Merck, consultancy for Organon and Norgine, and holding stock from ObsEva. The other authors report no conflict of interest., Trial Registration Number: NCT05168228., (© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology.)
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- 2024
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38. Brain activity during Stroop task performance at age 74 after exposure to the Dutch famine during early gestation.
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Boots A, Schrantee A, Wiegersma AM, Aflalo S, Groot PFC, Roseboom TJ, and de Rooij SR
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- Humans, Female, Male, Pregnancy, Aged, Netherlands, Prefrontal Cortex diagnostic imaging, Gyrus Cinguli diagnostic imaging, Gyrus Cinguli physiology, Parietal Lobe diagnostic imaging, Parietal Lobe physiology, Brain, Magnetic Resonance Imaging, Stroop Test, Famine, Prenatal Exposure Delayed Effects physiopathology
- Abstract
Objective: Poorer performance on the Stroop task has been reported after prenatal famine exposure at age 58, potentially indicating cognitive decline. We investigated whether brain activation during Stroop task performance at age 74 differed between individuals exposed to famine prenatally, individuals born before and individuals conceived after the famine., Method: In the Dutch famine birth cohort, we performed a Stroop task fMRI study of individuals exposed (n = 22) or unexposed (born before (n = 18) or conceived after (n = 25)) to famine in early gestation. We studied group differences in task-related mean activation of the dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex (ACC) and posterior parietal cortex (PPC). Additionally, we explored potential disconnectivity of the DLPFC using psychophysiological interaction analysis., Results: We observed similar activation patterns in the DLPFC, ACC and PPC in individuals born before and individuals exposed to famine, while individuals conceived after famine had generally higher activation patterns. However, activation patterns were not significantly different between groups. Task-related decreases in connectivity were observed between left DLPFC-left PPC and right DLPFC-right PPC, but were not significantly different between groups., Conclusions: Although not statistically significant, the observed patterns of activation may reflect a combined effect of general brain aging and prenatal famine exposure., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
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- 2024
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39. Fetal and post-natal outcomes in offspring after intrauterine metformin exposure: A systematic review and meta-analysis of animal experiments.
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van Hoorn EGM, Rademaker D, van der Wel AWT, DeVries JH, Franx A, van Rijn BB, Kooy A, Siegelaar SE, Roseboom TJ, Ozanne SE, Hooijmans CR, and Painter RC
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- Animals, Female, Humans, Animal Experimentation, Anthropometry, Hypoglycemic Agents adverse effects, Prenatal Care, Swine, Mice, Rats, Models, Animal, Pregnancy drug effects, Metformin adverse effects, Diabetes Mellitus drug therapy
- Abstract
Aims: The impact of maternal metformin use during pregnancy on fetal, infant, childhood and adolescent growth, development, and health remains unclear. Our objective was to systematically review the available evidence from animal experiments on the effects of intrauterine metformin exposure on offspring's anthropometric, cardiovascular and metabolic outcomes., Methods: A systematic search was conducted in PUBMED and EMBASE from inception (searched on 12th April 2023). We extracted original, controlled animal studies that investigated the effects of maternal metformin use during pregnancy on offspring anthropometric, cardiovascular and metabolic measurements. Subsequently, risk of bias was assessed and meta-analyses using the standardized mean difference and a random effects model were conducted for all outcomes containing data from 3 or more studies. Subgroup analyses were planned for species, strain, sex and type of model in the case of 10 comparisons or more per subgroup., Results: We included 37 articles (n = 3133 offspring from n = 716 litters, containing n = 51 comparisons) in this review, mostly (95%) on rodent models and 5% pig models. Follow-up of offspring ranged from birth to 2 years of age. Thirty four of the included articles could be included in the meta-analysis. No significant effects in the overall meta-analysis of metformin on any of the anthropometric, cardiovascular and metabolic offspring outcome measures were identified. Between-studies heterogeneity was high, and risk of bias was unclear in most studies as a consequence of poor reporting of essential methodological details., Conclusion: This systematic review was unable to establish effects of metformin treatment during pregnancy on anthropometric, cardiovascular and metabolic outcomes in non-human offspring. Heterogeneity between studies was high and reporting of methodological details often limited. This highlights a need for additional high-quality research both in humans and model systems to allow firm conclusions to be established. Future research should include focus on the effects of metformin in older offspring age groups, and on outcomes which have gone uninvestigated to date., (© 2023 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK.)
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- 2024
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40. Prenatal Exposure to the 1944-45 Dutch Famine and Risk for Dementia up to Age 75: An Analysis of Primary Care Data.
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Wiegersma AM, Boots A, van Bussel EF, Lissenberg-Witte BI, Nielen MMJ, Roseboom TJ, and de Rooij SR
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- Humans, Female, Male, Pregnancy, Netherlands epidemiology, Aged, Middle Aged, Primary Health Care, Incidence, Prenatal Exposure Delayed Effects epidemiology, Dementia epidemiology, Dementia etiology, Famine
- Abstract
Background: A poor prenatal environment adversely affects brain development. Studies investigating long-term consequences of prenatal exposure to the 1944-45 Dutch famine have shown that those exposed to famine in early gestation had poorer selective attention, smaller brain volumes, poorer brain perfusion, older appearing brains, and increased reporting of cognitive problems, all indicative of increased dementia risk., Objective: In the current population-based study, we investigated whether dementia incidence up to age 75 was higher among individuals who had been prenatally exposed to famine., Methods: We included men (n=6,714) and women (n=7,051) from the Nivel Primary Care Database who had been born in seven cities affected by the Dutch famine. We used Cox regression to compare dementia incidence among individuals exposed to famine during late (1,231), mid (1,083), or early gestation (601) with those unexposed (born before or conceived after the famine)., Results: We did not observe differences in dementia incidence for those exposed to famine in mid or early gestation compared to those unexposed. Men and women exposed to famine in late gestation had significantly lower dementia rates compared to unexposed individuals (HR 0.52 (95%CI 0.30-0.89)). Sex-specific analyses showed a lower dementia rate in women exposed to famine in late gestation (HR 0.39 (95%CI 0.17-0.86)) but not in men (HR 0.68 (95%CI 0.33-1.41))., Conclusion: Although prenatal exposure to the Dutch famine has previously been associated with measures of accelerated brain aging, the present population-based study did not show increased dementia incidence up to age 75 in those exposed to famine during gestation., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
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- 2024
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41. Gestational age and socio-demographic factors associated with school performance at the age of 12 years, a population-based study.
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Burger RJ, Roseboom TJ, Ganzevoort W, Gordijn SJ, Pajkrt E, Abu-Hanna A, Eskes M, Leemhuis AG, Mol BW, de Groot CJM, and Ravelli ACJ
- Subjects
- Adult, Child, Female, Humans, Infant, Infant, Newborn, Cohort Studies, Ethnicity, Gestational Age, Infant, Premature, Premature Birth, Academic Success
- Abstract
Background: Gestational age is positively associated with cognitive development, but socio-demographic factors also influence school performance. Previous studies suggested possible interaction, putting children with low socio-economic status (SES) at increased risk of the negative effects of prematurity., Objectives: To investigate the association between gestational age in weeks, socio-demographic characteristics, and school performance at the age of 12 years among children in regular primary education., Methods: Population-based cohort study among liveborn singletons (N = 860,332) born in the Netherlands in 1999-2006 at 25-42 weeks' gestation, with school performance from 2011 to 2019. Regression analyses were conducted investigating the association of gestational age and sociodemographic factors with school performance and possible interaction., Results: School performance increased with gestational age up to 40 weeks. This pattern was evident across socio-demographic strata. Children born at 25 weeks had -0.57 SD (95% confidence interval -0.79, -0.35) lower school performance z-scores and lower secondary school level compared to 40 weeks. Low maternal education, low maternal age, and non-European origin were strongly associated with lower school performance. Being born third or later and low socioeconomic status (SES) were also associated with lower school performance, but differences were smaller than among other factors. When born preterm, children from mothers with low education level, low or high age, low SES or children born third or later were at higher risk for lower school performance compared to children of mothers with intermediate education level, aged 25-29 years, with intermediate SES or first borns (evidence of interaction)., Conclusions: Higher gestational age is associated with better school performance at the age of 12 years along the entire spectrum of gestational age, beyond the cut-off of preterm birth and across socio-demographic differences. Children in socially or economically disadvantaged situations might be more vulnerable to the negative impact of preterm birth. Other important factors in school performance are maternal education, maternal age, ethnicity, birth order and SES. Results should be interpreted with caution due to differential loss to follow-up., (© 2023 The Authors. Paediatric and Perinatal Epidemiology published by John Wiley & Sons Ltd.)
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- 2023
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42. The impact of adversities across the lifespan on psychological symptom profiles in late adulthood: a latent profile analysis.
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Hilberdink CE, van Zuiden M, Olff M, Roseboom TJ, and de Rooij SR
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- Male, Child, Pregnancy, Humans, Female, Cross-Sectional Studies, Mental Health, Surveys and Questionnaires, Longevity, Stress Disorders, Post-Traumatic epidemiology, Stress Disorders, Post-Traumatic etiology, Stress Disorders, Post-Traumatic psychology
- Abstract
People commonly face adverse circumstances throughout life, which increases risk for psychiatric disorders, such as anxiety, depression, psychosis, and posttraumatic stress disorder (PTSD). Adversities may occur during different periods in life. Especially adversity during early periods has been suggested to put individuals at risk for adverse mental health outcomes. Here, we investigated whether timing of adversity during the prenatal period, childhood, or mid-to-late adulthood differentially impacted classification into late adulthood symptom profiles. We performed sex-stratified Latent Profile Analysis to identify latent profiles regarding anxious, depressive, psychotic, and PTSD symptoms in n = 568 Dutch famine birth cohort members ( n = 294 women, n = 274 men, mean age(SD) = 72.9(0.8)). Cross-sectional late adulthood symptomatology, childhood traumatic maltreatment, and adulthood trauma were based on self-report questionnaires. Prenatal adversity was considered present when individuals were prenatally exposed to the 1944-45 Dutch famine. In both men and women we identified one anxious/depressive profile and three profiles with approximately equal severity of all symptom types within each profile, yet differentiating in overall severity (low, mild, high) between profiles. We additionally found a PTSD symptom profile in women. In men, logistic regression models showed significant associations between prenatal, childhood and adulthood adversity, and profile classification, with differential effects depending on timing and most profound effects of child maltreatment. In women, childhood and adulthood adversity significantly increased classification probability into almost all profiles, with no significant effect of prenatal adversity. These findings support a time-dependent and sex-specific impact of adversity during different periods across the lifespan on psychological health, with consequences into late adulthood.
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- 2023
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43. A preconception lifestyle intervention in women with obesity and cardiovascular health in their children.
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den Harink T, Schuppen J, Marciniak M, Voet KA, Planken RN, Hoek A, Groen H, Gemke RJBJ, Mol BW, Blom NA, Lamata P, Roseboom TJ, and van Deutekom AW
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- Humans, Female, Pregnancy, Child, Male, Pulse Wave Analysis, Stroke Volume, Preconception Care methods, Ventricular Function, Left, Obesity complications, Obesity therapy, Life Style, Obesity, Maternal complications
- Abstract
Background: Maternal obesity during pregnancy is associated with poorer cardiovascular health (CVH) in children. A strategy to improve CVH in children could be to address preconception maternal obesity by means of a lifestyle intervention. We determined if a preconception lifestyle intervention in women with obesity improved offspring's CVH, assessed by magnetic resonance imaging (MRI)., Methods: We invited children born to women who participated in a randomised controlled trial assessing the effect of a preconception lifestyle intervention in women with obesity. We assessed cardiac structure, function and geometric shape, pulse wave velocity and abdominal fat tissue by MRI., Results: We included 49 of 243 (20.2%) eligible children, 24 girls (49%) girls, mean age 7.1 (0.8) years. Left ventricular ejection fraction was higher in children in the intervention group as compared to children in the control group (63.0% SD 6.18 vs. 58.8% SD 5.77, p = 0.02). Shape analysis showed that intervention was associated with less regional thickening of the interventricular septum and less sphericity. There were no differences in the other outcomes of interest., Conclusion: A preconception lifestyle intervention in women with obesity led to a higher ejection fraction and an altered cardiac shape in their offspring, which might suggest a better CVH., Impact: A preconception lifestyle intervention in women with obesity results in a higher ejection fraction and an altered cardiac shape that may signify better cardiovascular health (CVH) in their children. This is the first experimental human evidence suggesting an effect of a preconception lifestyle intervention in women with obesity on MRI-derived indicators of CVH in their children. Improving maternal preconception health might prevent some of the detrimental consequences of maternal obesity on CVH in their children., (© 2023. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.)
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- 2023
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44. Cancer risk in children, adolescents, and young adults conceived by ART in 1983-2011.
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Spaan M, Pontesilli M, van den Belt-Dusebout AW, Burger CW, van den Heuvel-Eibrink MM, Ravelli ACJ, Goddijn M, Lambalk CB, Roseboom TJ, and van Leeuwen FE
- Abstract
Study Question: Do children, adolescents, and young adults born after ART, including IVF, ICSI and frozen-thawed embryo transfer (FET), have an increased risk of cancer compared with children born to subfertile couples not conceived by ART and children from the general population?, Summary Answer: After a median follow-up of 18 years, the overall cancer risk was not increased in children conceived by ART, but a slight risk increase was observed in children conceived after ICSI., What Is Known Already: There is growing evidence that ART procedures could perturb epigenetic processes during the pre-implantation period and influence long-term health. Recent studies showed (non-)significantly increased cancer risks after ICSI and FET, but not after IVF., Study Design Size Duration: A nationwide historical cohort study with prospective follow-up was carried out, including all live-born offspring from women treated with ART between 1983 and 2011 and subfertile women not treated with ART in one of the 13 Dutch IVF clinics and two fertility centers., Participants/materials Setting Methods: Children were identified through the mothers' records in the Personal Records Database. Information on the conception method of each child was collected through the mother's medical record. In total, the cohort comprises 89 249 live-born children of subfertile couples, of whom 51 417 were conceived using ART and 37 832 were not (i.e. conceived naturally, through ovulation induction, or after IUI). Cancer incidence was ascertained through linkage with the Netherlands Cancer Registry for the period 1989-2019. Cancer risk in children conceived using ART was compared with risk in children born to subfertile couples but not conceived by ART (hazard ratio (HR)) and children from the general population (standardized incidence ratios (SIRs))., Main Results and the Role of Chance: In total, 358 cancers were observed after a median follow-up of 18 years. Overall cancer risk was not increased in children conceived using ART, when compared with the general population (SIR = 0.96, 95% CI = 0.81-1.12) or with children from subfertile couples not conceived by ART (HR = 1.06, 95% CI = 0.84-1.33). Compared with children from subfertile couples not conceived by ART, the use of IVF or FET was not associated with increased cancer risk, but ICSI was associated with a slight risk increase (HR = 1.58, 95% CI = 1.08-2.31). Risk of cancer after ART did not increase at older ages (≥18 years, HR = 1.26, 95% CI = 0.88-1.81) compared to cancer risk in children not conceived by ART., Limitations Reasons for Caution: The observed increased risk among children conceived using ICSI must be interpreted with caution owing to the small number of cases., Wider Implications of the Findings: After a median follow-up of 18 years, children conceived using ART do not have an increased overall cancer risk. Many large studies with prolonged follow-up are needed to investigate cancer risk in (young) adults conceived by different types of ART. In addition, international pooling of studies is recommended to provide sufficient power to study risk of specific cancer sites after ART., Study Funding/competing Interests: This work was supported by The Dutch Cancer Society (NKI 2006-3631) that funded the OMEGA-women's cohort, Children Cancer Free (KIKA; 147) that funded the OMEGA-I-II offspring cohort. The OMEGA-III offspring cohort was supported by a Postdoc Stipend of Amsterdam Reproduction & Development, and the Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health under Award Number R01HD088393. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors declare no competing interests., Trial Registration Number: N/A., Competing Interests: The authors declare no competing interests., (© The Author(s) 2023. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology.)
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- 2023
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45. Offspring physiology following the use of IVM, IVF and ICSI: a systematic review and meta-analysis of animal studies.
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Beilby KH, Kneebone E, Roseboom TJ, van Marrewijk IM, Thompson JG, Norman RJ, Robker RL, Mol BWJ, and Wang R
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- Animals, Male, Humans, Cattle, Horses, Sheep, Mice, Sperm Injections, Intracytoplasmic methods, Reproductive Techniques, Assisted, Fertilization, Proteins, Mammals, Fertilization in Vitro methods, Infertility therapy
- Abstract
Background: Since the birth of the first baby using IVF technology in 1978, over 10 million children have been conceived via ART. Although most aspects of ARTs were developed in animal models, the introduction of these technologies into clinical practice was performed without comprehensive assessment of their long-term safety. The monitoring of these technologies over time has revealed differences in the physiology of babies produced using ARTs, yet due to the pathology of those presenting for treatment, it is challenging to separate the cause of infertility from the effect of treatments offered. The use of systematic review and meta-analysis to investigate the impacts of the predominant ART interventions used clinically in human populations on animals produced in healthy fertile populations offers an alternative approach to understanding the long-term safety of reproductive technologies., Objective and Rationale: This systematic review and meta-analysis aimed to examine the evidence available from animal studies on physiological outcomes in the offspring conceived after IVF, IVM or ICSI, compared to in vivo fertilization, and to provide an overview on the landscape of research in this area., Search Methods: PubMed, Embase and Commonwealth Agricultural Bureaux (CAB) Abstracts were searched for relevant studies published until 27 August 2021. Search terms relating to assisted reproductive technology, postnatal outcomes and mammalian animal models were used. Studies that compared postnatal outcomes between in vitro-conceived (IVF, ICSI or IVM) and in vivo-conceived mammalian animal models were included. In vivo conception included mating, artificial insemination, or either of these followed by embryo transfer to a recipient animal with or without in vitro culture. Outcomes included birth weight, gestation length, cardiovascular, metabolic and behavioural characteristics and lifespan., Outcomes: A total of 61 studies in five different species (bovine, equine, murine, ovine and non-human primate) met the inclusion criteria. The bovine model was the most frequently used in IVM studies (32/40), while the murine model was mostly used in IVF (17/20) and ICSI (6/8) investigations. Despite considerable heterogeneity, these studies suggest that the use of IVF or maturation results in offspring with higher birthweights and a longer length of gestation, with most of this evidence coming from studies in cattle. These techniques may also impair glucose and lipid metabolism in male mice. The findings on cardiovascular outcomes and behaviour outcomes were inconsistent across studies., Wider Implications: Conception via in vitro or in vivo means appears to have an influence on measurable outcomes of offspring physiology, manifesting differently across the species studied. Importantly, it can be noted that these measurable differences are noticeable in healthy, fertile animal populations. Thus, common ART interventions may have long-term consequences for those conceived through these techniques, regardless of the pathology underpinning diagnosed infertility. However, due to heterogeneous methods, results and measured outcomes, highlighted in this review, it is difficult to draw firm conclusions. Optimizing animal and human studies that investigate the safety of new reproductive technologies will provide insight into safeguarding the introduction of novel interventions into the clinical setting. Cautiously prescribing the use of ARTs clinically may also be considered to reduce the chance of promoting adverse outcomes in children conceived before long-term safety is confidently documented., (© The Author(s) 2023. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology.)
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- 2023
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46. Childhood outcomes after induction of labor or expectant management for preterm prelabor rupture of membranes: a 10-year follow-up of the PPROMEXIL trials.
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Simons NE, de Ruigh AA, van 't Hooft J, Aarnoudse-Moens CSH, van Wely M, van der Ham DP, van Teeffelen ASP, Roseboom TJ, Mol BW, Leemhuis AG, and Pajkrt E
- Subjects
- Child, Pregnancy, Female, Infant, Newborn, Humans, Follow-Up Studies, Labor, Induced methods, Watchful Waiting, Pregnancy Outcome, Randomized Controlled Trials as Topic, Fetal Membranes, Premature Rupture therapy, Premature Birth epidemiology
- Abstract
Background: Management of late preterm prelabor rupture of membranes between 34+0 and 36+6 weeks' gestation balances the risks of preterm birth with the risks of infection for both the mother and the neonate. Expectant management to prolong pregnancy showed similar risks of neonatal sepsis, but children at 2 years of age showed more neurodevelopmental delay when compared with induction of labor. Long-term outcomes on child development after 2 years of age are unknown., Objective: This study aimed to assess the long-term outcomes of children born after singleton pregnancies complicated by late preterm prelabor rupture of membranes managed by induction of labor in comparison with expectant management., Study Design: This was a follow-up study of the Preterm Prelabor Rupture of Membranes Expectant Management Versus Induction of Labor (PPROMEXIL) trials (randomized controlled trials between 2007 to 2011) evaluating children at 10 to 12 years of age (Netherlands Trial Register 6953). The primary outcomes were cognition, motor function, and behavior as assessed by the Wechsler Intelligence Scale for Children-V-NL, Movement Assessment Battery for Children-2, and Child Behavior Checklist, respectively. The secondary outcomes were sensory processing, respiratory problems, educational attainment, and general health. Mild delay was defined as -1 standard deviation or corresponding percentile. The relative risk and confidence intervals were calculated using standard methods., Results: This follow-up study invited 711 surviving children of the 714 singleton pregnancies randomized in the original trials. In total, 248 (35%) children participated (127 induction of labor, 121 expectant management). Children born after induction of labor had no significant differences in the primary outcomes when compared with those born after expectant management. Mild cognitive delay was observed in 7 of 122 (5.7%) children born after induction of labor in comparison with in 12 of 120 (10.0%) children born after expectant management (relative risk, 0.57; 95% confidence interval, 0.23-1.41). A mild delay in motor function was observed in 42 of 122 (34.4%) children born after induction of labor vs in 55 of 120 (45.8%) children born after expectant management (relative risk, 0.75; 95% confidence interval, 0.55-1.03). Mild abnormal behavior was observed in 37 of 125 (29.6%) children born after induction of labor compared with in 33 of 118 (28.0%) children born after expectant management (relative risk, 1.05; 95% confidence interval, 0.71-1.57). Secondary outcomes were also comparable between the induction of labor and the expectant management groups except that more children born after expectant management had a hospital admission (relative risk, 0.68; 95% confidence interval, 0.52-0.89) or a surgery (relative risk, 0.58; 95% confidence interval, 0.41-0.82)., Conclusion: In children born after pregnancies with late preterm prelabor rupture of membranes, expectant management did not improve long-term outcomes at 10 to 12 years when compared with induction of labor., (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
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- 2023
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47. Perinatal outcomes of infants born to mothers with hyperemesis gravidarum: A systematic review and meta-analysis.
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Jansen LAW, Nijsten K, Limpens J, van Eekelen R, Koot MH, Grooten IJ, Roseboom TJ, and Painter RC
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- Infant, Newborn, Humans, Pregnancy, Female, Pregnancy Outcome, Stillbirth, Birth Weight, Placenta, Resuscitation, Nausea, Infant, Very Low Birth Weight, Hyperemesis Gravidarum complications, Hyperemesis Gravidarum epidemiology, Premature Birth epidemiology, Premature Birth etiology, Gestational Weight Gain, Malnutrition complications
- Abstract
Background: Hyperemesis gravidarum is the severe form of nausea and vomiting during pregnancy and can lead to undernutrition and low maternal weight gain. Previous epidemiologic and animal studies have shown that undernutrition and low maternal weight gain in pregnancy can increase the risk of unfavorable perinatal outcomes, like shorter gestational age, small for gestational age and lower weight at birth., Objective: To evaluate the effect of hyperemesis gravidarum on perinatal outcomes., Search Strategy: OVID Medline and Embase were searched from inception to February 9th, 2022., Study Eligibility: Studies reporting on perinatal outcomes of infants born to mothers with hyperemesis gravidarum or severe nausea and vomiting in pregnancy were included. Case reports, case series, animal studies, reviews, editorials and conference abstracts were excluded., Data Collection and Analysis: Two reviewers independently selected and extracted data. Risk of bias was assessed by the Newcastle-Ottawa Quality Assessment Scale. We conducted meta-analyses where possible., Results: Our search yielded 1387 unique papers, of which 61 studies (n = 20,532,671 participants) were included in our systematic review. Meta-analyses showed that hyperemesis gravidarum was associated with preterm birth < 34 weeks (2 studies n = 2,882: OR 2.81, 95 %CI: 1.69-4.67), birth weight < 1500 g (2 studies, n = 489,141: OR 1.43, 95 %CI: 1.02-1.99), neonatal resuscitation (2 studies, n = 4,289,344: OR 1.07, 95 %CI: 1.05-1.10), neonatal intensive care unit admission (7 studies, n = 6,509,702: OR 1.20, 95 %CI: 1.14-1.26) and placental abruption (6 studies, n = 9,368,360: OR 1.15, 95 %CI: 1.05-1.25). Hyperemesis gravidarum was associated with reductions in birthweight > 4000 g (2 studies, n = 5,503,120: OR 0.74, 95 %CI: 0.72-0.76) and stillbirth (9 studies, n = 3,973,154: OR 0.92, 95 %CI: 0.85-0.99). Meta-analyses revealed no association between hyperemesis gravidarum and Apgar scores < 7 at 1 and 5 min; fetal loss, perinatal deaths and neonatal deaths., Conclusion: Hyperemesis gravidarum is associated with several adverse perinatal outcomes including low birth weight and preterm birth. We also found that pregnancies complicated by hyperemesis gravidarum less frequently were complicated by macrosomia and stillbirth. We were unable to investigate underlying mechanisms., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.)
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- 2023
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48. Do prenatal factors shape the risk for dementia?: A systematic review of the epidemiological evidence for the prenatal origins of dementia.
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Wiegersma AM, Boots A, Langendam MW, Limpens J, Shenkin SD, Korosi A, Roseboom TJ, and de Rooij SR
- Abstract
Purpose: Prenatal factors such as maternal stress, infection and nutrition affect fetal brain development and may also influence later risk for dementia. The purpose of this systematic review was to provide an overview of all studies which investigated the association between prenatal factors and later risk for dementia., Methods: We systematically searched MEDLINE and Embase for original human studies reporting on associations between prenatal factors and dementia from inception to 23 November 2022. Prenatal factors could be any factor assessed during pregnancy, at birth or postnatally, provided they were indicative of a prenatal exposure. Risk of bias was assessed using the Newcastle Ottawa Scale. We followed PRISMA guidelines for reporting., Results: A total of 68 studies met eligibility criteria (including millions of individuals), assessing maternal age (N = 30), paternal age (N = 22), birth order (N = 15), season of birth (N = 16), place of birth (N = 13), prenatal influenza pandemic (N = 1) or Chinese famine exposure (N = 1), birth characteristics (N = 3) and prenatal hormone exposure (N = 4). We observed consistent results for birth in a generally less optimal environment (e.g. high infant mortality area) being associated with higher dementia risk. Lower and higher birth weight and prenatal famine exposure were associated with higher dementia risk. The studies on season of birth, digit ratio, prenatal influenza pandemic exposure, parental age and birth order showed inconsistent results and were hampered by relatively high risk of bias., Conclusion: Our findings suggest that some prenatal factors, especially those related to a suboptimal prenatal environment, are associated with an increased dementia risk. As these associations may be confounded by factors such as parental socioeconomic status, more research is needed to examine the potential causal role of the prenatal environment in dementia., (© 2023. The Author(s).)
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- 2023
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49. Shaping the risk for late-life neurodegenerative disease: A systematic review on prenatal risk factors for Alzheimer's disease-related volumetric brain biomarkers.
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Boots A, Wiegersma AM, Vali Y, van den Hof M, Langendam MW, Limpens J, Backhouse EV, Shenkin SD, Wardlaw JM, Roseboom TJ, and de Rooij SR
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- Humans, Female, Pregnancy, Child, Placenta pathology, Brain pathology, Biomarkers, Magnetic Resonance Imaging, Risk Factors, Alzheimer Disease psychology, Neurodegenerative Diseases, Prenatal Exposure Delayed Effects
- Abstract
Environmental exposures including toxins and nutrition may hamper the developing brain in utero, limiting the brain's reserve capacity and increasing the risk for Alzheimer's disease (AD). The purpose of this systematic review is to summarize all currently available evidence for the association between prenatal exposures and AD-related volumetric brain biomarkers. We systematically searched MEDLINE and Embase for studies in humans reporting on associations between prenatal exposure(s) and AD-related volumetric brain biomarkers, including whole brain volume (WBV), hippocampal volume (HV) and/or temporal lobe volume (TLV) measured with structural magnetic resonance imaging (PROSPERO; CRD42020169317). Risk of bias was assessed using the Newcastle Ottawa Scale. We identified 79 eligible studies (search date: August 30th, 2020; Ntotal=24,784; median age 10.7 years) reporting on WBV (N = 38), HV (N = 63) and/or TLV (N = 5) in exposure categories alcohol (N = 30), smoking (N = 7), illicit drugs (N = 14), mental health problems (N = 7), diet (N = 8), disease, treatment and physiology (N = 10), infections (N = 6) and environmental exposures (N = 3). Overall risk of bias was low. Prenatal exposure to alcohol, opioids, cocaine, nutrient shortage, placental dysfunction and maternal anemia was associated with smaller brain volumes. We conclude that the prenatal environment is important in shaping the risk for late-life neurodegenerative disease., Competing Interests: Declaration of Competing Interest none., (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2023
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50. Exposure to the Dutch Famine in Early Gestation and Cognitive Function and Decline in Older Age.
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Wiegersma AM, Boots A, Roseboom TJ, and de Rooij SR
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- Male, Pregnancy, Humans, Female, Aged, Middle Aged, Famine, Cohort Studies, Cognition, Netherlands epidemiology, Starvation complications, Malnutrition complications, Malnutrition epidemiology, Prenatal Exposure Delayed Effects
- Abstract
People exposed to the 1944-1945 Dutch famine in early gestation performed worse on a selective attention task at age 58 and reported more cognitive problems at age 72. We here hypothesized that undernutrition in early gestation is associated with poorer cognitive functioning in older age and a higher rate of cognitive decline. We tested this hypothesis in the Dutch famine birth cohort in men and women combined and separately. We assessed cognitive function using a Stroop-like, trail-making and 15-word task (at ages 68 and 74) and the Montreal cognitive assessment as well as self-perceived cognitive problems (at age 74) in 73 men ( n = 34) and women ( n = 39). We compared cognitive function and decline (change in cognitive function between age 68 and 74) between those exposed in early gestation and those not exposed (born before or conceived after the famine). Although in both men and women cognitive function declined from age 68 to 74, cognitive task scores and the rate of decline did not differ between those exposed or unexposed to famine. At age 74, men exposed to famine in early gestation more often reported cognitive problems, although this was not statistically different from unexposed men (OR 3.1 [95%CI 0.7 to 13.0]). We did not find evidence of increased cognitive decline after prenatal undernutrition. Selective participation and mortality may have hampered our ability to detect potential true effects. The self-perceived cognitive problems among men who had been exposed to famine in early gestation might be an indication of future dementia risk.
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- 2023
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