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215 results on '"Rose, Thierry"'

3. Low seroprevalence of COVID-19 in Lao PDR, late 2020

Author

Virachith, Siriphone, Pommelet, Virginie, Calvez, Elodie, Khounvisith, Vilaysone, Sayasone, Somphou, Kounnavong, Sengchanh, Mayxay, Mayfong, Xangsayarath, Phonepadith, Temmam, Sarah, Eloit, Marc, Escriou, Nicolas, Rose, Thierry, Vongphayloth, Khamsing, Hübschen, Judith M., Lacoste, Vincent, Somlor, Somphavanh, Phonekeo, Darouny, Brey, Paul T., and Black, Antony P.

Published
2021
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5. Rocuronium-specific antibodies drive perioperative anaphylaxis but can also function as reversal agents in preclinical models.

Author

Dejoux, Alice, Zhu, Qianqian, Ganneau, Christelle, Goff, Odile Richard-Le, Godon, Ophélie, Lemaitre, Julien, Relouzat, Francis, Huetz, François, Sokal, Aurélien, Vandenberghe, Alexis, Pecalvel, Cyprien, Hunault, Lise, Derenne, Thomas, Gillis, Caitlin M., Iannascoli, Bruno, Wang, Yidan, Rose, Thierry, Mertens, Christel, Nicaise-Roland, Pascale, and England, Patrick

Subjects
IMMUNOGLOBULIN E, IMMUNOLOGIC memory, NEUROMUSCULAR blocking agents, NEUROMUSCULAR blockade, MAST cells
Abstract

Neuromuscular blocking agents (NMBAs) relax skeletal muscles to facilitate surgeries and ease intubation but can lead to adverse reactions, including complications because of postoperative residual neuromuscular blockade (rNMB) and, in rare cases, anaphylaxis. Both adverse reactions vary between types of NMBAs, with rocuronium, a widely used nondepolarizing NMBA, inducing one of the longest rNMB durations and highest anaphylaxis incidences. rNMB induced by rocuronium can be reversed by the synthetic γ-cyclodextrin sugammadex. However, in rare cases, sugammadex can provoke anaphylaxis. Thus, additional therapeutic options are needed. Rocuronium-induced anaphylaxis is proposed to rely on preexisting rocuronium-binding antibodies. To understand the pathogenesis of rocuronium-induced anaphylaxis and to identify potential therapeutics, we investigated the memory B cell antibody repertoire of patients with suspected hypersensitivity to rocuronium. We identified polyclonal antibody repertoires with a high diversity among V(D)J genes without evidence of clonal groups. When recombinantly expressed, these antibodies demonstrated specificity and low affinity for rocuronium without cross-reactivity for other NMBAs. Moreover, when these antibodies were expressed as human immunoglobulin E (IgE), they triggered human mast cell activation and passive systemic anaphylaxis in transgenic mice, although their affinities were insufficient to serve as reversal agents. Rocuronium-specific, high-affinity antibodies were thus isolated from rocuronium-immunized mice. The highest-affinity antibody was able to reverse rocuronium-induced neuromuscular blockade in nonhuman primates with kinetics comparable to that of sugammadex. Together, these data support the hypothesis that antibodies cause anaphylactic reactions to rocuronium and pave the way for improved diagnostics and neuromuscular blockade reversal agents. Editor's summary: Neuromuscular blocking agents (NMBAs) such as rocuronium are used during anesthesia to assist with surgeries and intubations. Although these agents are effective, they are not without risk. Patients can develop postoperative residual neuromuscular blockade, which can be treated with an NMBA reversal agent, and life-threatening anaphylaxis can occur in rare cases. Here, Dejoux et al. isolated and characterized memory B cells from three individuals who developed reactions to NMBA treatment and had serum antibodies to rocuronium. The authors found that IgE antibodies generated from these memory B cells were sufficient to induce anaphylaxis in mice treated with rocuronium, although they were too low affinity to be used as reversal agents. This led the authors to immunize mice with rocuronium to generate antibodies of higher affinity, which were able to reverse neuromuscular blockade in rocuronium-treated nonhuman primates. Together, these data explain why these three patients had a reaction and offer a therapeutic approach to reversing neuromuscular blockade. —Courtney Malo [ABSTRACT FROM AUTHOR]

Published
2024
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6. Fibronectin induces a transition from amoeboid to a fan morphology and modifies migration in Entamoeba histolytica.

Author

Manich, Maria, Bochet, Pascal, Boquet-Pujadas, Aleix, Rose, Thierry, Laenen, Gertjan, Guillén, Nancy, Olivo-Marin, Jean-Christophe, and Labruyère, Elisabeth

Subjects
FIBRONECTINS, ENTAMOEBA histolytica, CELL motility, MORPHOLOGY, CELL adhesion, WATERBORNE infection, LAMINAR flow, CELL morphology
Abstract

Cell migration modes can vary, depending on a number of environmental and intracellular factors. The high motility of the pathogenic amoeba Entamoeba histolytica is a decisive factor in its ability to cross the human colonic barrier. We used quantitative live imaging techniques to study the migration of this parasite on fibronectin, a key tissue component. Entamoeba histolytica amoebae on fibronectin contain abundant podosome-like structures. By using a laminar flow chamber, we determined that the adhesion forces generated on fibronectin were twice those on non-coated glass. When migrating on fibronectin, elongated amoeboid cells converted into fan-shaped cells characterized by the presence of a dorsal column of F-actin and a broad cytoplasmic extension at the front. The fan shape depended on the Arp2/3 complex, and the amoebae moved laterally and more slowly. Intracellular measurements of physical variables related to fluid dynamics revealed that cytoplasmic pressure gradients were weaker within fan-shaped cells; hence, actomyosin motors might be less involved in driving the cell body forward. We also found that the Rho-associated coiled-coil containing protein kinase regulated podosome dynamics. We conclude that E. histolytica spontaneously changes its migration mode as a function of the substrate composition. This adaptive ability might favour E. histolytica's invasion of human colonic tissue. By combining microfluidic experiments, mechanical modelling, and image analysis, our work also introduces a computational pipeline for the study of cell migration. Author summary: Even though we know increasingly well how cells move in tissues, the question of whether parasites modify their migration as a function of the host tissue environment requires further investigation. Cell motility is triggered by environmental stimuli, and the migration mode depends on adhesion, activated enzymatic pathways, and changes in the actin cytoskeleton dynamics and thus cell morphology. The protozoan intestinal parasitic Entamoeba histolytica is the causative agent of amoebiasis (a major food- and water-borne disease) in humans. During invasion of the colon, E. histolytica degrades the mucus layer, adheres to and removes the epithelium, progresses along the fibronectin-rich basement membrane towards the crypts of Lieberkühn, and penetrates the mucosa. This invasive process raises the question of how the parasite moves in a varying intestinal environment. E. histolytica is known to display an amoeboid migration mode and binds fibronectin through podosome adhesion structures. We hypothesized that fibronectin triggers signalling pathways that influence the trophozoite's migration. We found that E. histolytica can migrate with a non-amoeboid mode on fibronectin-coated glass. Our finding suggests that for tissue invasion, E. histolytica's migration mode is modulated to suit the environment. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Molecular allergen sensitization drives phenotypes of severe asthma in children: evidence from a megacity cohort (SAMP)

Author

Bourgoin-Heck, Mélisande, primary, Wolff-Goldnadel, Victoria, additional, Chantran, Yannick, additional, Saf, Sarah, additional, Guiddir, Tamazoust, additional, Amat, Flore, additional, Rancière, Fanny, additional, Momas, Isabelle, additional, Wanin, Stéphanie, additional, Saint-Pierre, Philippe, additional, Rose, Thierry, additional, and J, Just, additional

Published
2024
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9. PLA2G1B is involved in CD4 anergy and CD4 lymphopenia in HIV-infected patients

Author

Pothlichet, Julien, Rose, Thierry, Bugault, Florence, Jeammet, Louise, Meola, Annalisa, Haouz, Ahmed, Saul, Frederick, Geny, David, Alcami, Jose, Ruiz-Mateos, Ezequiel, Teyton, Luc, Lambeau, Gerard, and Theze, Jacques

Subjects
HIV patients -- Physiological aspects, HIV infections -- Physiological aspects, Lymphocytopenia -- Physiological aspects, HIV -- Physiological aspects, Immunotherapy -- Physiological aspects, T cells -- Physiological aspects, Health care industry
Abstract

The precise mechanism leading to profound immunodeficiency of HIV-infected patients is still only partially understood. Here, we show that more than 80% of [CD4.sup.+] T cells from HIV-infected patients have morphological abnormalities. Their membranes exhibited numerous large abnormal membrane microdomains (aMMDs), which trap and inactivate physiological receptors, such as that for IL-7. In patient plasma, we identified phospholipase A2 group IB (PLA2G1B) as the key molecule responsible for the formation of aMMDs. At physiological concentrations, PLA2G1B synergized with the HIV gp41 envelope protein, which appears to be a driver that targets PLA2G1B to the [CD4.sup.+] T cell surface. The PLA2G1B/gp41 pair induced [CD4.sup.+] T cell unresponsiveness (anergy). At high concentrations in vitro, PLA2G1B acted alone, independently of gp41, and inhibited the IL-2, IL-4, and IL-7 responses, as well as TCR-mediated activation and proliferation, of [CD4.sup.+] T cells. PLA2G1B also decreased [CD4.sup.+] T cell survival in vitro, likely playing a role in CD4 lymphopenia in conjunction with its induced IL-7 receptor defects. The effects on [CD4.sup.+] T cell anergy could be blocked by a PLA2G1B- specific neutralizing mAb in vitro and in vivo. The PLA2G1B/gp41 pair constitutes what we believe is a new mechanism of immune dysfunction and a compelling target for boosting immune responses in HIV-infected patients., Introduction [CD4.sup.+] lymphocytes play a critical role in the severe immunodeficiency that characterizes HIV-infected patients. Although fewer than 0.5% of blood [CD4.sup.+] T cells are infected, almost all are dysfunctional. [...]

Published
2020
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10. Prevalence of SARS-CoV-2 antibodies in France: results from nationwide serological surveillance

Author

Le Vu, Stéphane, Jones, Gabrielle, Anna, François, Rose, Thierry, Richard, Jean-Baptiste, Bernard-Stoecklin, Sibylle, Goyard, Sophie, Demeret, Caroline, Helynck, Olivier, Escriou, Nicolas, Gransagne, Marion, Petres, Stéphane, Robin, Corinne, Monnet, Virgile, Perrin de Facci, Louise, Ungeheuer, Marie-Noelle, Léon, Lucie, Guillois, Yvonnick, Filleul, Laurent, Charneau, Pierre, Lévy-Bruhl, Daniel, van der Werf, Sylvie, and Noel, Harold

Published
2021
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11. Application of Machine Learning Prediction of Individual SARS-CoV-2 Vaccination and Infection Status to the French Serosurveillance Survey From March 2020 to 2022: Cross-Sectional Study

Author

Bougeard, Stéphanie, primary, Huneau-Salaun, Adeline, additional, Attia, Mikael, additional, Richard, Jean-Baptiste, additional, Demeret, Caroline, additional, Platon, Johnny, additional, Allain, Virginie, additional, Le Vu, Stéphane, additional, Goyard, Sophie, additional, Gillon, Véronique, additional, Bernard-Stoecklin, Sibylle, additional, Crescenzo-Chaigne, Bernadette, additional, Jones, Gabrielle, additional, Rose, Nicolas, additional, van der Werf, Sylvie, additional, Lantz, Olivier, additional, Rose, Thierry, additional, and Noël, Harold, additional

Published
2023
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15. Application of Machine Learning Prediction of Individual SARS-CoV-2 Vaccination and Infection Status to the French Serosurveillance Survey From March 2020 to 2022: Cross-Sectional Study (Preprint)

Author

Bougeard, Stéphanie, primary, Huneau-Salaun, Adeline, additional, Attia, Mikael, additional, Richard, Jean-Baptiste, additional, Demeret, Caroline, additional, Platon, Johnny, additional, Allain, Virginie, additional, Le Vu, Stéphane, additional, Goyard, Sophie, additional, Gillon, Véronique, additional, Bernard-Stoecklin, Sibylle, additional, Crescenzo-Chaigne, Bernadette, additional, Jones, Gabrielle, additional, Rose, Nicolas, additional, van der Werf, Sylvie, additional, Lantz, Olivier, additional, Rose, Thierry, additional, and Noël, Harold, additional

Published
2023
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18. The tumor suppressor adenomatous polyposis coli regulates T lymphocyte migration

Author

Mastrogiovanni, Marta, primary, Vargas, Pablo, additional, Rose, Thierry, additional, Cuche, Céline, additional, Esposito, Elric, additional, Juzans, Marie, additional, Laude, Hélène, additional, Schneider, Amandine, additional, Bernard, Mathilde, additional, Goyard, Sophie, additional, Renaudat, Charlotte, additional, Ungeheuer, Marie-Noëlle, additional, Delon, Jérôme, additional, Alcover, Andrés, additional, and Di Bartolo, Vincenzo, additional

Published
2022
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23. High-risk exposure without personal protective equipment and infection with SARS-CoV-2 in-hospital workers - The CoV-CONTACT cohort

Author

Duval, Xavier, Burdet, Charles, Lina, Bruno, Tubiana, Sarah, Van Der Werf, Sylvie, Abad, Fanny, Abry, Dominique, Alavoine, Loubna, Allain, Jean-Sébastien, Amiel-Taieb, Karline, Audoin, Pierre, Augustin, Shana, Ayala, Sandrine, Bansard, Hélène, Bertholon, Fréderique, Boissel, Nolwenn, Botelho-Nevers, Elisabeth, Bouiller, Kévin, Bourgeon, Marilou, Boutrou, Mathilde, Brick, Lysiane, Bruneau, Léa, Caumes, Eric, Chabouis, Agnès, Chan Thien, Eric, Chirouze, Catherine, Coignard, Bruno, Costa, Yolande, Costenoble, Virginie, Cour, Sylvie, Cracowski, Claire, Cracowski Jean, Luc, Deplanque, Dominique, Dequand, Stéphane, Desille-Dugast, Mireille, Desmarets, Maxime, Detoc, Maelle, Dewitte, Marie, Djossou, Felix, Ecobichon, Jean-Luc, Elrezzi, Elise, Faurous, William, Fortuna, Viviane, Fouchard, Julie, Gantier, Emilie, Gautier, Céline, Gerardin, Patrick, Gerset, Sandrine, Gilbert, Marie, Gissot, Valérie, Guillemin, Francis, Hartard, Cédric, Hazevis, Béatrice, Hocquet, Didier, Hodaj, Enkelejda, Ilic-Habensus, Emila, A, Jeudy, Jeulin, Helene, Kane, Maty, Kasprzyk, Emmanuelle, Kikoine, John, Laine, Fabrice, Laviolle, Bruno, Lebeaux, David, Leclercq, Anne, Ledru, Eric, Lefevre, Benjamin, Legoas, Carole, Legrand, Amélie, Legrand, Karine, Lehacaut, Jonathan, Lehur, Claire, Lemouche, Dalila, Lepiller, Quentin, Lepuil, Sévérine, Letienne, Estelle, Lucarelli, Aude, Lucet, Jean-Christophe, Madeline, Isabelle, Maillot, Adrien, Malapate, Catherine, Malvy, Denis, Mandic, Milica, Marty-Quinternet, Solène, Meghadecha, Mohamed, Mergeay-Fabre, Mayka, Mespoulhe, Pauline, Meunier, Alexandre, Migaud, Maria-Claire, Motiejunaite, Justina, Nathalie, Gay, Nguyen, Duc, Oubbea, Soumaya, Pagadoy, Maïder, Paris, Adeline, Paris, Christophe, Payet, Christine, Peiffer-Smadja, Nathan, Perez, Lucas, Perreau, Pauline, Pierrez, Nathalie, Pistone, Thierry, Postolache, Andreea, Rasoamanana, Patrick, Reminiac, Cécile, Rexah, Jade, Roche-Gouanvic, Elise, Rousseau, Alexandra, Schoemaecker, Betty, Simon, Sandrine, Soler, Catherine, Somers, Stéphanie, Sow, Khaly, Tardy, Bernard, Terzian, Zaven, Thy, Michael, Tournier, Anne, Tyrode, Sandrine, Vauchy, Charline, Verdon, Renaud, Vernet, Pauline, Vignali, Valérie, Waucquier, Nawal, Do Thi Thu, Huong, Laouénan, Cédric, Mentre, France, Pauline, Manchon, Dechanet, Aline, Letrou, Sophie, Quintin, Caroline, Frezouls, Wahiba, Le Hingrat, Quentin, Houhou, Nadhira, Damond, Florence, Descamps, Dianes, Charpentier, Charlotte, Visseaux, Benoit, Vabret, Astrid, Bouscambert, Maud, Behillil, Sylvie, Gaillanne, Laurence, Benmalek, Nabil, Attia, Mikael, Barbet, Marion, Demeret, Caroline, Rose, Thierry, Petres, Stéphane, Escriou, Nicolas, Goyard, Sophie, Kafif, Ouifiya, Piquard, Valentine, Mailles, Alexandra, Simondon, Anne, Dreyere, Marion, Morel, Bruno, Vesval, Thiphaine, Amat, Karine, Ammour, Douae, Aqourras, Khadija, Couffin-Cadiergues, Sandrine, Delmas, Christelle, Desan, Vristi, Jean, Michel Doute, Esperou, Hélène, Hendou, Samia, Kouakam, Christelle, Le Meut, Guillaume, Lemestre, Soizic, Leturque, Nicolas, Marcoul, Emmanuelle, Nguefang, Solange, Roufai, Layidé, Abel, Laurent, Caillat-Zucman, Sophie, Manchon, Pauline, Blanquart, François, Guedj, Jérémie, Yazdanpanah, Yazdan, Attia, Mikaël, Bielicki, Julia Anna, Bruijning-Verhagen, Patricia, Goossens, Herman, Descamps, Diane, and van der Werf, Sylvie

Published
2021
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24. High-risk exposure without personal protective equipment and infection with SARS-CoV-2 in-hospital workers - The CoV-CONTACT cohort

Author

Tubiana, Sarah, Burdet, Charles, Houhou, Nadhira, Thy, Michael, Manchon, Pauline, Blanquart, François, Charpentier, Charlotte, Guedj, Jérémie, Alavoine, Loubna, Behillil, Sylvie, Leclercq, Anne, Lucet, Jean-Christophe, Yazdanpanah, Yazdan, Attia, Mikaël, Demeret, Caroline, Rose, Thierry, Bielicki, Julia Anna, Bruijning-Verhagen, Patricia, Goossens, Herman, Descamps, Diane, van der Werf, Sylvie, Lina, Bruno, Duval, Xavier, Abad, Fanny, Abry, Dominique, Allain, Jean-Sébastien, Amiel-Taieb, Karline, Audoin, Pierre, Augustin, Shana, Ayala, Sandrine, Bansard, Hélène, Bertholon, Fréderique, Boissel, Nolwenn, Botelho-Nevers, Elisabeth, Bouiller, Kévin, Bourgeon, Marilou, Boutrou, Mathilde, Brick, Lysiane, Bruneau, Léa, Caumes, Eric, Chabouis, Agnès, Chan Thien, Eric, Chirouze, Catherine, Coignard, Bruno, Costa, Yolande, Costenoble, Virginie, Cour, Sylvie, Cracowski, Claire, Cracowski Jean, Luc, Deplanque, Dominique, Dequand, Stéphane, Desille-Dugast, Mireille, Desmarets, Maxime, Detoc, Maelle, Dewitte, Marie, Djossou, Felix, Ecobichon, Jean-Luc, Elrezzi, Elise, Faurous, William, Fortuna, Viviane, Fouchard, Julie, Gantier, Emilie, Gautier, Céline, Gerardin, Patrick, Gerset, Sandrine, Gilbert, Marie, Gissot, Valérie, Guillemin, Francis, Hartard, Cédric, Hazevis, Béatrice, Hocquet, Didier, Hodaj, Enkelejda, Ilic-Habensus, Emila, A, Jeudy, Jeulin, Helene, Kane, Maty, Kasprzyk, Emmanuelle, Kikoine, John, Laine, Fabrice, Laviolle, Bruno, Lebeaux, David, Ledru, Eric, Lefevre, Benjamin, Legoas, Carole, Legrand, Amélie, Legrand, Karine, Lehacaut, Jonathan, Lehur, Claire, Lemouche, Dalila, Lepiller, Quentin, Lepuil, Sévérine, Letienne, Estelle, Lucarelli, Aude, Madeline, Isabelle, Maillot, Adrien, Malapate, Catherine, Malvy, Denis, Mandic, Milica, Marty-Quinternet, Solène, Meghadecha, Mohamed, Mergeay-Fabre, Mayka, Mespoulhe, Pauline, Meunier, Alexandre, Migaud, Maria-Claire, Motiejunaite, Justina, Nathalie, Gay, Nguyen, Duc, Oubbea, Soumaya, Pagadoy, Maïder, Paris, Adeline, Paris, Christophe, Payet, Christine, Peiffer-Smadja, Nathan, Perez, Lucas, Perreau, Pauline, Pierrez, Nathalie, Pistone, Thierry, Postolache, Andreea, Rasoamanana, Patrick, Reminiac, Cécile, Rexah, Jade, Roche-Gouanvic, Elise, Rousseau, Alexandra, Schoemaecker, Betty, Simon, Sandrine, Soler, Catherine, Somers, Stéphanie, Sow, Khaly, Tardy, Bernard, Terzian, Zaven, Tournier, Anne, Tyrode, Sandrine, Vauchy, Charline, Verdon, Renaud, Vernet, Pauline, Vignali, Valérie, Waucquier, Nawal, Do Thi Thu, Huong, Laouénan, Cédric, Mentre, France, Pauline, Manchon, Dechanet, Aline, Letrou, Sophie, Quintin, Caroline, Frezouls, Wahiba, Le Hingrat, Quentin, Damond, Florence, Descamps, Dianes, Visseaux, Benoit, Vabret, Astrid, Bouscambert, Maud, Gaillanne, Laurence, Benmalek, Nabil, Attia, Mikael, Barbet, Marion, Petres, Stéphane, Escriou, Nicolas, Goyard, Sophie, Kafif, Ouifiya, Piquard, Valentine, Mailles, Alexandra, Simondon, Anne, Dreyere, Marion, Morel, Bruno, Vesval, Thiphaine, Amat, Karine, Ammour, Douae, Aqourras, Khadija, Couffin-Cadiergues, Sandrine, Delmas, Christelle, Desan, Vristi, Jean, Michel Doute, Esperou, Hélène, Hendou, Samia, Kouakam, Christelle, Le Meut, Guillaume, Lemestre, Soizic, Leturque, Nicolas, Marcoul, Emmanuelle, Nguefang, Solange, Roufai, Layidé, Abel, Laurent, Caillat-Zucman, Sophie, Study Group, Covcontact, Centre d'investigation Clinique [CHU Bichat] - Épidémiologie clinique (CIC 1425), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses (GMV-ARN (UMR_3569 / U-Pasteur_2)), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre National de Référence des virus des infections respiratoires (dont la grippe) - National Reference Center Virus Influenzae [Paris] (CNR - laboratoire coordonnateur), Institut Pasteur [Paris] (IP), Hôpital Beaujon [AP-HP], Physique des fonctions biologiques / Physics of Biological Functions, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Biologie Cellulaire des Lymphocytes - Lymphocyte Cell Biology, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), St George's, University of London, University Children’s Hospital Basel = Hôpital pédiatrique universitaire des deux Bâle [Bâle, Suisse] (UKBB), University Medical Center [Utrecht], Universiteit Antwerpen = University of Antwerpen [Antwerpen], Virology and human respiratory Pathologies - Virology and human respiratory Pathologies (VirPath), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de Référence des Virus des Infections Respiratoires (dont la Grippe) [Lyon] (CNR - laboratoire associé), Institut des Agents Infectieux [Lyon] (IAI), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), CHU Pontchaillou [Rennes], Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), ANR-20-COVI-0002,CORaDiag,COVID 19 Rapid diagnosis test (development and clinical validation in 7 weeks)(2020), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Microbiology (medical), medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Health Personnel, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), [SDV]Life Sciences [q-bio], Pneumonia, Viral, Sars-cov-2, Betacoronavirus, 03 medical and health sciences, Health personnel, 0302 clinical medicine, High-risk exposure, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Personal protective equipment, medicine, Humans, Risk exposure, Transmission, 030212 general & internal medicine, Letter to the Editor, Pandemics, ComputingMilieux_MISCELLANEOUS, 0303 health sciences, 030306 microbiology, Transmission (medicine), business.industry, COVID-19, 3. Good health, Infectious Diseases, Cohort, Emergency medicine, In-hospital workers, Human medicine, Coronavirus Infections, business
Abstract

International audience

Published
2021
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25. Cutting Edge: Neutralizing Public Antibody Responses Are an Ancient Form of Defense Conserved in Fish and Mammals

Author

Castro, Rosario, primary, Navelsaker, Sofie, additional, Collet, Bertrand, additional, Jouneau, Luc, additional, Bochet, Pascal, additional, Quillet, Edwige, additional, Evensen, Øystein, additional, Sunyer, J. Oriol, additional, Fillatreau, Simon, additional, Bruhns, Pierre, additional, Rose, Thierry, additional, Huetz, François, additional, and Boudinot, Pierre, additional

Published
2021
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26. High-risk exposure without personal protective equipment and infection with SARS-CoV-2 in-hospital workers - The CoV-CONTACT cohort

Author

Epi Infectieziekten Team 1, Child Health, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Tubiana, Sarah, Burdet, Charles, Houhou, Nadhira, Thy, Michael, Manchon, Pauline, Blanquart, François, Charpentier, Charlotte, Guedj, Jérémie, Alavoine, Loubna, Behillil, Sylvie, Leclercq, Anne, Lucet, Jean-Christophe, Yazdanpanah, Yazdan, Attia, Mikaël, Demeret, Caroline, Rose, Thierry, Bielicki, Julia Anna, Bruijning-Verhagen, Patricia, Goossens, Herman, Descamps, Diane, van der Werf, Sylvie, Lina, Bruno, Duval, Xavier, Epi Infectieziekten Team 1, Child Health, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Tubiana, Sarah, Burdet, Charles, Houhou, Nadhira, Thy, Michael, Manchon, Pauline, Blanquart, François, Charpentier, Charlotte, Guedj, Jérémie, Alavoine, Loubna, Behillil, Sylvie, Leclercq, Anne, Lucet, Jean-Christophe, Yazdanpanah, Yazdan, Attia, Mikaël, Demeret, Caroline, Rose, Thierry, Bielicki, Julia Anna, Bruijning-Verhagen, Patricia, Goossens, Herman, Descamps, Diane, van der Werf, Sylvie, Lina, Bruno, and Duval, Xavier

Published
2021

27. The tumor suppressor Adenomatous polyposis coli regulates T lymphocyte migration. Insights from familial polyposis patients

Author

Mastrogiovanni, Marta, primary, Vargas, Pablo, additional, Rose, Thierry, additional, Cuche, Céline, additional, Juzans, Marie, additional, Esposito, Elric, additional, Laude, Hélène, additional, Renaudat, Charlotte, additional, Ungeheuer, Marie-Noëlle, additional, Delon, Jérôme, additional, Alcover, Andrés, additional, and Di Bartolo, Vincenzo, additional

Published
2021
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28. PLA2G1B is involved in CD4 anergy and CD4 lymphopenia in HIV-infected patients

Author

Agence Nationale de la Recherche (France), Institut Pasteur, Pothlichet, Julien, Rose, Thierry, Bugault, Florence, Jeammet, Louise, Meola, Annalisa, Haouz, Ahmed, Saul, Frederick, Geny, David, Alcamí, José, Ruiz-Mateos, Ezequiel, Teyton, Luc, Lambeau, Gérard, Thèze, Jacques, Agence Nationale de la Recherche (France), Institut Pasteur, Pothlichet, Julien, Rose, Thierry, Bugault, Florence, Jeammet, Louise, Meola, Annalisa, Haouz, Ahmed, Saul, Frederick, Geny, David, Alcamí, José, Ruiz-Mateos, Ezequiel, Teyton, Luc, Lambeau, Gérard, and Thèze, Jacques

Abstract

The precise mechanism leading to profound immunodeficiency of HIV-infected patients is still only partially understood. Here, we show that more than 80% of CD4+ T cells from HIV-infected patients have morphological abnormalities. Their membranes exhibited numerous large abnormal membrane microdomains (aMMDs), which trap and inactivate physiological receptors, such as that for IL-7. In patient plasma, we identified phospholipase A2 group IB (PLA2G1B) as the key molecule responsible for the formation of aMMDs. At physiological concentrations, PLA2G1B synergized with the HIV gp41 envelope protein, which appears to be a driver that targets PLA2G1B to the CD4+ T cell surface. The PLA2G1B/gp41 pair induced CD4+ T cell unresponsiveness (anergy). At high concentrations in vitro, PLA2G1B acted alone, independently of gp41, and inhibited the IL-2, IL-4, and IL-7 responses, as well as TCR-mediated activation and proliferation, of CD4+ T cells. PLA2G1B also decreased CD4+ T cell survival in vitro, likely playing a role in CD4 lymphopenia in conjunction with its induced IL-7 receptor defects. The effects on CD4+ T cell anergy could be blocked by a PLA2G1B-specific neutralizing mAb in vitro and in vivo. The PLA2G1B/gp41 pair constitutes what we believe is a new mechanism of immune dysfunction and a compelling target for boosting immune responses in HIV-infected patients.

Published
2020

30. Low Seroprevalence of COVID-19 in Lao PDR, Late 2020

Author

Virachith, Siriphone, primary, Pommelet, Virginie, additional, Calvez, Elodie, additional, Khounvisith, Vilaysone, additional, Sayasone, Somphou, additional, Kounnavong, Sengchanh, additional, Maxay, Mayfong, additional, Xangsayarath, Phonepadith, additional, Temmam, Sarah, additional, Eloit, Marc, additional, Escriou, Nicolas, additional, Rose, Thierry, additional, Vongphayltoh, Khamsing, additional, Hübschen, Judith M., additional, Lacoste, Vincent, additional, Somlor, Somphavanh, additional, Phonekeo, Darouny, additional, Brey, Paul, additional, and Black, Antony Paul, additional

Published
2021
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31. Molecular basis of inward rectification: polyamine interaction sites located by combined channel and ligand mutagenesis

Author

Kurata, Harley T., Phillips, L. Revell, Rose, Thierry, Loussouarn, Gildas, Herlitze, Stefan, Fritzenschaft, Hariolf, Enkvetchakul, Decha, Nichols, Colin G., and Baukrowitz, Thomas

Subjects
Polyamines -- Research, Polyamines -- Physiological aspects, Physiology -- Research, Biological sciences, Health
Abstract

Polyamines cause inward rectification of (Kir) [K.sup.+] channels, but the mechanism is controversial. We employed scanning mutagenesis of Kir6.2, and a structural series of blocking diamines, to combinatorially examine the role of both channel and blocker charges. We find that introduced glutamates at any pore-facing residue in the inner cavity, up to and including the entrance to the selectivity filter, can confer strong rectification. As these negative charges are moved higher (toward the selectivity filter), or lower (toward the cytoplasm), they. preferentially enhance the potency of block by shorter, or longer, diamines, respectively. MTSE[A.sup.+] modification of engineered cysteines in the inner cavity reduces rectification, but modification below the inner cavity slows spermine entry and exit, without changing steady-state rectification. The data provide a coherent explanation of classical strong rectification as the result of polyamine block in the inner cavity and selectivity filter. KEY WORDS: inward rectifier * spermine * diamine * rectification * selectivity filter

Published
2004

32. Calorimetric and structural studies of 1,2,3-trisubstituted cyclopropanes as conformationally constrained peptide inhibitors of Src SH2 domain binding

Author

Davidson, James P., Lubman, Olga, Rose, Thierry, Waksman, Gabriel, and Martin, Stephen F.

Subjects
Calorimetry -- Usage, X-ray crystallography -- Usage, Cyclopropane compounds -- Structure, Chemistry
Abstract

Isothermal titration calorimetry and X-ray crystallography are used to determine the structural and thermodynamic consequences associated with constraining the pTyr residue of the pYEE Iigand for the Src homology two domain of the Src kinase. It is observed that drop in enthalpy with the conformationally constrained peptide mimic arises from sources other than changes in buried surface areas, though the exact origin of the differences remain unclear.

Published
2002

33. Structural basis of the interaction of the pyelonephritic E. coli adhesin to its human kidney receptor

Author

Dodson, Karen W., Pinkner, Jerome S., Rose, Thierry, Magnusson, Goran, Hultgren, Scott J., and Waksman, Gabriel

Subjects
Cell research -- Analysis, Escherichia coli -- Physiological aspects, Pathogenic microorganisms -- Physiological aspects, Kidney diseases -- Causes of, Biological sciences
Abstract

Research has been conducted on the PapG, the adhesin at the tip of the P pilus which mediates the uropathogenic Escherichia coli attachment to the human kidney uroepithelium. The crystal structures of the PapG receptor binding domain's binary complex bound to the globoside have been investigated and the results are reported.

Published
2001

35. High seroprevalence but short‐lived immune response to SARS‐CoV‐2 infection in Paris

Author

Anna, François, primary, Goyard, Sophie, additional, Lalanne, Ana Ines, additional, Nevo, Fabien, additional, Gransagne, Marion, additional, Souque, Philippe, additional, Louis, Delphine, additional, Gillon, Véronique, additional, Turbiez, Isabelle, additional, Bidard, François‐Clément, additional, Gobillion, Aline, additional, Savignoni, Alexia, additional, Guillot‐Delost, Maude, additional, Dejardin, François, additional, Dufour, Evelyne, additional, Petres, Stéphane, additional, Richard‐Le Goff, Odile, additional, Choucha, Zaineb, additional, Helynck, Olivier, additional, Janin, Yves L., additional, Escriou, Nicolas, additional, Charneau, Pierre, additional, Perez, Franck, additional, Rose, Thierry, additional, and Lantz, Olivier, additional

Published
2020
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36. Prevalence of SARS-CoV-2 antibodies in France: results from nationwide serological surveillance

Author

Vu, Stéphane Le, primary, Jones, Gabrielle, additional, Anna, François, additional, Rose, Thierry, additional, Richard, Jean-Baptiste, additional, Bernard-Stoecklin, Sibylle, additional, Goyard, Sophie, additional, Demeret, Caroline, additional, Helynck, Olivier, additional, Robin, Corinne, additional, Monnet, Virgile, additional, Facci, Louise Perrin de, additional, Ungeheuer, Marie-Noelle, additional, Léon, Lucie, additional, Guillois, Yvonnick, additional, Filleul, Laurent, additional, Charneau, Pierre, additional, Lévy-Bruhl, Daniel, additional, van der Werf, Sylvie, additional, and Noel, Harold, additional

Published
2020
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37. High seroprevalence of SARS-CoV-2 antibodies among people living in precarious situations in Ile de France

Author

Roederer, Thomas, primary, Mollo, Bastien, additional, Vincent, Charline, additional, Nikolay, Birgit, additional, Llosa, Augusto, additional, Nesbitt, Robin, additional, Vanhomwegen, Jessica, additional, Rose, Thierry, additional, Anna, François, additional, Torre, Corinne, additional, Fourrey, Emilie, additional, Simons, Erica, additional, Goyard, Sophie, additional, Janin, Yves, additional, Charneau, Pierre, additional, Vratskikh, Oxana, additional, Coury, Anneliese, additional, Vanel, Stefan, additional, Mendiharat, Pierre, additional, Porten, Klaudia, additional, Hennequin, William, additional, Mills, Clair, additional, and Luquero, Francisco, additional

Published
2020
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38. High-risk exposure without personal protective equipment and infection with SARS-CoV-2 in healthcare workers: results of the CoV-CONTACT prospective cohort

Author

Tubiana, Sarah, primary, Burdet, Charles, additional, Houhou, Nadhira, additional, Thy, Michael, additional, Manchon, Pauline, additional, Blanquart, François, additional, Charpentier, Charlotte, additional, Guedj, Jérémie, additional, Alavoine, Loubna, additional, Behillil, Sylvie, additional, Leclercq, Anne, additional, Lucet, Jean-Christophe, additional, Yazdanpanah, Yazdan, additional, Attia, Mikaël, additional, Demeret, Caroline, additional, Rose, Thierry, additional, Bielicki, Julia Anna, additional, Bruijning-Verhagen, Patricia, additional, Goossens, Herman, additional, Descamps, Diane, additional, van der Werf, Sylvie, additional, Lina, Bruno, additional, and Duval, Xavier, additional

Published
2020
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42. Identification of a binding site for quaternary amines in factor Xa

Author

Monnaie, Dadier, Arosio, Daniele, Griffon, Nathalie, Rose, Thierry, Resaie, Alireza R., and Di Cera, Enrico

Subjects
Biochemistry -- Research, Amines -- Research, Sodium -- Research, Factor analysis -- Evaluation, Biological sciences, Chemistry
Abstract

Research has been conducted on the Na (super)+ -binding properties of factor X. The characterization of these properties is described.

Published
2000

44. Solution structure of a homopyrimidine:homopurine dodecamer encoded by the HIV-1 envelope gene: NMR and molecular simulation studies

Author

Sodano, Patrick, Hartmann, Brigitte, Rose, Thierry, Wain-Hobson, Simon, and Delepierre, Muriel

Subjects
Proteins -- Structure, Nucleotide sequence -- Research, Nuclear magnetic resonance spectroscopy -- Usage, Molecular spectroscopy -- Usage, Biological sciences, Chemistry
Abstract

A combination of two-dimensional nuclear magnetic resonance spectroscopy and molecular simulation was used to derive the solution structure of the nonpalindromic dodecanucleotide homopyrimidine:homopurine. The dodecamer sequence in question was located within the HIV-1 envelope sequence. All four Gs in two hypermutants were substituted by A. The solution structure derived resulted in a set of low-energy B-DNA conformations satisfying the nuclear Overhauser effect data.

Published
1995

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