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153 results on '"Rose, Stephen L."'

3. Circadian actigraphic rest–activity rhythms following surgery for endometrial cancer: A prospective, longitudinal study

Author

Rumble, Meredith E, Rose, Stephen L, White, Kaitlin Hanley, Moore, A Holliston, Gehrman, Philip, Benca, Ruth M, and Costanzo, Erin S

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Cancer, Uterine Cancer, Clinical Research, Actigraphy, Circadian Rhythm, Endometrial Neoplasms, Female, Humans, Longitudinal Studies, Middle Aged, Prospective Studies, Circadian activity rhythm, Endometrial cancer, Laparoscopic, Laparotomy, Obesity, Paediatrics and Reproductive Medicine, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis, Reproductive medicine
Abstract

ObjectiveTo investigate (1) circadian rest-activity rhythm disturbances among endometrial cancer patients as they recover from surgery in comparison to a historical reference group of women with no cancer history and (2) health- and treatment-related predictors of dysregulated rest-activity rhythms in endometrial cancer patients.Methods60 endometrial cancer patients participated in a prospective, longitudinal study with actigraphic assessment at 1week, 1month, and 4months post-surgery. 60 women without cancer from an epidemiological sample completed one actigraphic assessment, acting as a reference group.ResultsOn average, results revealed initial significant rest-activity dysregulation at 1week and 1month post-surgery for the endometrial cancer group and then significant recovery in rest-activity patterns at 4months post-surgery. Similarly, the cancer group had significantly more impaired rhythms than the reference group at 1week post-surgery, but demonstrated comparable rhythms by 4months post-surgery. Among the health- and treatment-related variables examined, obesity and receipt of more invasive surgery were found to predict more impaired rhythms at all time points.Conclusion(s)The current study highlights significant disturbances in rest-activity patterns for endometrial cancer patients initially during surgical recovery followed by improvement in these patterns by 4months post-surgery; however, obese patients and those having more invasive surgery demonstrated more impaired rest-activity patterns throughout the 4-month recovery period. Further research is warranted to understand how more impaired rest-activity patterns relate to health and quality of life outcomes.

Published
2015

21. Recurrence Rates in Patients With Cervical Cancer Treated With Abdominal Versus Minimally Invasive Radical Hysterectomy: A Multi-Institutional Retrospective Review Study

Author

Uppal, Shitanshu, primary, Gehrig, Paola A., additional, Peng, Katherine, additional, Bixel, Kristin L., additional, Matsuo, Koji, additional, Vetter, Monica H., additional, Davidson, Brittany A., additional, Cisa, M. Paige, additional, Lees, Brittany F., additional, Brunette, Laurie L., additional, Tucker, Katherine, additional, Stuart Staley, Allison, additional, Gotlieb, Walter H., additional, Holloway, Robert W., additional, Essel, Kathleen G., additional, Holman, Laura L., additional, Goldfeld, Ester, additional, Olawaiye, Alexander, additional, and Rose, Stephen L., additional

Published
2020
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22. O-RADS US Risk Stratification and Management System: A Consensus Guideline from the ACR Ovarian-Adnexal Reporting and Data System Committee

Author

Andreotti, Rochelle F., primary, Timmerman, Dirk, additional, Strachowski, Lori M., additional, Froyman, Wouter, additional, Benacerraf, Beryl R., additional, Bennett, Genevieve L., additional, Bourne, Tom, additional, Brown, Douglas L., additional, Coleman, Beverly G., additional, Frates, Mary C., additional, Goldstein, Steven R., additional, Hamper, Ulrike M., additional, Horrow, Mindy M., additional, Hernanz-Schulman, Marta, additional, Reinhold, Caroline, additional, Rose, Stephen L., additional, Whitcomb, Brad P., additional, Wolfman, Wendy L., additional, and Glanc, Phyllis, additional

Published
2020
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26. Recurrence rates in cervical cancer patients treated with abdominal versus minimally invasive radical hysterectomy: A multi-institutional analysis of 700 cases.

Author

Uppal, Shitanshu, primary, Gehrig, Paola, additional, Vetter, Monica Hagan, additional, Davidson, Brittany Anne, additional, Lees, Brittany F, additional, Brunette, Laurie Leigh, additional, Tucker, Katherine, additional, Matsuo, Koji, additional, Bixel, Kristin Leigh, additional, Staley, Allison Stuart, additional, Gotlieb, Walter H., additional, Holloway, Robert W., additional, Moore, Kathleen N., additional, and Rose, Stephen L., additional

Published
2019
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27. DNA methylation changes in ovarian cancer are cumulative with disease progression and identify tumor stage

Author

DeGeest Koen, Holtan Nicholas, Futscher Bernard W, Watts George S, Domann Frederick E, and Rose Stephen L

Subjects
Internal medicine, RC31-1245, Genetics, QH426-470
Abstract

Abstract Background Hypermethylation of promoter CpG islands with associated loss of gene expression, and hypomethylation of CpG-rich repetitive elements that may destabilize the genome are common events in most, if not all, epithelial cancers. Methods The methylation of 6,502 CpG-rich sequences spanning the genome was analyzed in 137 ovarian samples (ten normal, 23 low malignant potential, 18 stage I, 16 stage II, 54 stage III, and 16 stage IV) ranging from normal tissue through to stage IV cancer using a sequence-validated human CpG island microarray. The microarray contained 5' promoter-associated CpG islands as well as CpG-rich satellite and Alu repetitive elements. Results Results showed a progressive de-evolution of normal CpG methylation patterns with disease progression; 659 CpG islands showed significant loss or gain of methylation. Satellite and Alu sequences were primarily associated with loss of methylation, while promoter CpG islands composed the majority of sequences with gains in methylation. Since the majority of ovarian tumors are late stage when diagnosed, we tested whether DNA methylation profiles could differentiate between normal and low malignant potential (LMP) compared to stage III ovarian samples. We developed a class predictor consisting of three CpG-rich sequences that was 100% sensitive and 89% specific when used to predict an independent set of normal and LMP samples versus stage III samples. Bisulfite sequencing confirmed the NKX-2-3 promoter CpG island was hypermethylated with disease progression. In addition, 5-aza-2'-deoxycytidine treatment of the ES2 and OVCAR ovarian cancer cell lines re-expressed NKX-2-3. Finally, we merged our CpG methylation results with previously published ovarian expression microarray data and identified correlated expression changes. Conclusion Our results show that changes in CpG methylation are cumulative with ovarian cancer progression in a sequence-type dependent manner, and that CpG island microarrays can rapidly discover novel genes affected by CpG methylation in clinical samples of ovarian cancer.

Published
2008
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32. Non-Gynecologic Laparoscopy in Second and Third Trimester Pregnancy: Obstetric Implications

Author

Geisler, John P., Rose, Stephen L., Mernitz, Christopher S., Warner, Janice L., and Hiett, A. Kinney

Subjects
Non-gynecologic laparoscopy, Adult, Pregnancy Trimester, Third, Pregnancy Outcome, Tocolysis, Gestational Age, Appendicitis, Prognosis, Pregnancy Complications, Pregnancy, Pregnancy Trimester, Second, Scientific Papers, Cholecystitis, Humans, Laparoscopy, Female, Registries, Follow-Up Studies, Retrospective Studies
Abstract

Purpose: To review the effect of non-gynecologic laparoscopic procedures performed during the second and third trimesters of pregnancy on pregnancy outcome. Materials and Methods: A review of the patient log for the antenatal obstetrical unit was used to identify the patients in this series from January 1, 1997 to December 31, 1997. Medical records were then analyzed to identify estimated gestational age at surgery and delivery, type of delivery, use of tocolysis, and complications from surgery. Results: Nine patients were identified as having non-gynecologic laparoscopic surgery (without conversion to laparotomy) during the second or third trimester of pregnancy. The median estimated gestational age at surgery was 25 weeks (mean 24 weeks). The most common procedure performed was laparoscopic cholecystectomy (6 patients). Five patients received tocolysis after the initial procedure. All patients delivered at greater than or equal to 37 weeks estimated gestational age (median 38 weeks). No infants were admitted to the neonatal intensive care unit. Conclusions: Laparoscopic procedures appear safe in second and third trimester pregnancy. In this study, laparoscopic cholecystectomies were performed as late as 34 weeks estimated gestational age without any adverse effects on pregnancy outcome.

Published
1998

47. Roles of KLF6 and KLF6-SV1 in Ovarian Cancer Progression and Intraperitoneal Dissemination

Author

DiFeo, Analisa, primary, Narla, Goutham, additional, Hirshfeld, Jennifer, additional, Camacho-Vanegas, Olga, additional, Narla, Jyothsna, additional, Rose, Stephen L., additional, Kalir, Tamara, additional, Yao, Shen, additional, Levine, Alice, additional, Birrer, Michael J., additional, Bonome, Tomas, additional, Friedman, Scott L., additional, Buller, Richard E., additional, and Martignetti, John A., additional

Published
2006
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