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2. Banff 2022 Kidney Commentary: Reflections and Future Directions

Author

Rabant, Marion, Adam, Benjamin A., Aubert, Olivier, Böhmig, Georg A., Clahsen Van-Groningen, Marian, Cornell, Lynn D., de Vries, Aiko P.J., Huang, Edmund, Kozakowski, Nicolas, Perkowska-Ptasinska, Agnieszka, Riella, Leonardo V., Rosales, Ivy A., Schinstock, Carrie, Simmonds, Naomi, Thaunat, Olivier, and Willicombe, Michelle

Published
2024
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3. Dysfunction of infiltrating cytotoxic [CD8.sup.+] T cells within the graft promotes murine kidney allotransplant tolerance

Author

Yokose, Takahiro, Szuter, Edward S., Rosales, Ivy, Guinn, Michael T., Liss, Andrew S., Baba, Taisuke, Ruddy, David A., Piquet, Michelle, Azzi, Jamil, Cosimi, A. Benedict, Russell, Paul S., Madsen, Joren C., Colvin, Robert B., and Alessandrini, Alessandro

Subjects
CD8 lymphocytes -- Health aspects -- Genetic aspects, RNA sequencing -- Methods, Lymphoid tissue -- Health aspects -- Genetic aspects
Abstract

Tolerance of mouse kidney allografts arises in grafts that develop regulatory tertiary lymphoid organs (rTLOs). Singlecell RNA-seq (scRNA-seq) data and adoptive transfer of alloreactive T cells after transplantation showed that cytotoxic [CD8.sup.+] T cells are reprogrammed within the accepted graft to an exhausted/regulatory-like phenotype mediated by IFN-[gamma]. Establishment of rTLOs was required because adoptive transfer of alloreactive T cells prior to transplantation results in kidney allograft rejection. Despite the presence of intragraft [CD8.sup.+] cells with a regulatory phenotype, they were not essential for the induction and maintenance of kidney allograft tolerance since renal allotransplantation into CD8-KO recipients resulted in acceptance and not rejection. Analysis of scRNA-seq data from allograft kidneys and malignant tumors identified similar regulatory-like cell types within the T cell clusters and trajectory analysis showed that cytotoxic [CD8.sup.+] T cells are reprogrammed into an exhausted/regulatory-like phenotype intratumorally. Induction of cytotoxic [CD8.sup.+] T cell dysfunction of infiltrating cells appears to be a beneficial mechanistic pathway that protects the kidney allotransplant from rejection through a process we call "defensive tolerance." This pathway has implications for our understanding of allotransplant tolerance and tumor resistance to host immunity., Introduction Traditionally, inflammatory and regulatory immune responses after transplantation were thought to be primarily generated in secondary lymphoid organs (1, 2). However, it has been increasingly recognized that both deleterious [...]

Published
2024
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5. Design and testing of a humanized porcine donor for xenotransplantation

Author

Anand, Ranjith P., Layer, Jacob V., Heja, David, Hirose, Takayuki, Lassiter, Grace, Firl, Daniel J., Paragas, Violette B., Akkad, Adam, Chhangawala, Sagar, Colvin, Robert B., Ernst, Russell J., Esch, Nicholas, Getchell, Kristen, Griffin, Alexandra K., Guo, Xiaoyun, Hall, Katherine C., Hamilton, Paula, Kalekar, Lokesh A., Kan, Yinan, Karadagi, Ahmad, Li, Feng, Low, Susan C., Matheson, Rudy, Nehring, Claudia, Otsuka, Ryo, Pandelakis, Matthew, Policastro, Robert A., Pols, Rebecca, Queiroz, Luis, Rosales, Ivy A., Serkin, William T., Stiede, Kathryn, Tomosugi, Toshihide, Xue, Yongqiang, Zentner, Gabriel E., Angeles-Albores, David, Chris Chao, J., Crabtree, Juliet N., Harken, Sierra, Hinkle, Nicole, Lemos, Tania, Li, Mailin, Pantano, Lorena, Stevens, Denise, Subedar, Omar D., Tan, Xiaoqing, Yin, Shiyi, Anwar, Imran J., Aufhauser, David, Capuano, Saverio, Kaufman, Dixon B., Knechtle, Stuart J., Kwun, Jean, Shanmuganayagam, Dhanansayan, Markmann, James F., Church, George M., Curtis, Mike, Kawai, Tatsuo, Youd, Michele E., and Qin, Wenning

Published
2023
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6. Corrigendum: Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis

Author

Moledina, Dennis G., Obeid, Wassim, Smith, Rex N., Rosales, Ivy, Sise, Meghan E., Moeckel, Gilbert, Kashgarian, Michael, Kuperman, Michael, Campbell, Kirk N., Lefferts, Sean, Meliambro, Kristin, Bitzer, Markus, Perazella, Mark A., Luciano, Randy L., Pober, Jordan S., Cantley, Lloyd G., Colvin, Robert B., Wilson, F. Perry, and Parikh, Chirag R.

Subjects
Proteins, Kidney diseases -- Diagnosis, Health care industry
Abstract

In the abstract and the legend for Figure 1, the descriptions of the Olink Proteomics assays utilized were incorrect. The correct descriptions appear below. The HTML and PDF versions of [...]

Published
2024
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8. Multiomic profiling of transplant glomerulopathy reveals a novel T-cell dominant subclass

Author

Cristoferi, Iacopo, Varol, Hilal, van Baardwijk, Myrthe, Rahiem, Layla, Lila, Karishma A., van den Bosch, Thierry P.P., Baan, Carla C., Hesselink, Dennis A., Kramann, Rafael, Minnee, Robert C., Mustafa, Dana A.M., Reinders, Marlies E.J., Roelen, Dave L., Shahzad-Arshad, Shazia P., Smith, Rex N., Stubbs, Andrew P., Colvin, Robert B., Rosales, Ivy A., and Clahsen-van Groningen, Marian C.

Published
2024
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9. The Banff 2022 Kidney Meeting Work Plan: Data-driven refinement of the Banff Classification for renal allografts

Author

Roufosse, Candice, Naesens, Maarten, Haas, Mark, Lefaucheur, Carmen, Mannon, Roslyn B., Afrouzian, Marjan, Alachkar, Nada, Aubert, Olivier, Bagnasco, Serena M., Batal, Ibrahim, Bellamy, Chris O.C., Broecker, Verena, Budde, Klemens, Clahsen-Van Groningen, Marian, Coley, Shana M., Cornell, Lynn D., Dadhania, Darshana, Demetris, Anthony J., Einecke, Gunilla, Farris, Alton B., Fogo, Agnes B., Friedewald, John, Gibson, Ian W., Horsfield, Catherine, Huang, Edmund, Husain, Syed A., Jackson, Annette M., Kers, Jesper, Kikić, Željko, Klein, Amanda, Kozakowski, Nicolas, Liapis, Helen, Mangiola, Massima, Montgomery, Robert A., Nankinvell, Brian, Neil, Desley A.H., Nickerson, Peter, Rabant, Marion, Randhawa, Parmjeet, Riella, Leonardo V., Rosales, Ivy, Royal, Virginie, Sapir-Pichhadze, Ruth, Sarder, Pinaki, Sarwal, Minnie, Schinstock, Carrie, Stegall, Mark, Solez, Kim, van der Laak, Jeroen, Wiebe, Chris, Colvin, Robert B., Loupy, Alexandre, and Mengel, Michael

Published
2024
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10. Extended survival of 9- and 10-gene-edited pig heart xenografts with ischemia minimization and CD154 costimulation blockade-based immunosuppression

Author

Chaban, Ryan, Ileka, Ikechukwu, McGrath, Gannon, Kinoshita, Kohei, Habibabady, Zahra, Ma, Madelyn, Diaz, Victoria, Maenaka, Akihiro, Calhoun, Anthony, Dufault, Megan, Rosales, Ivy, Laguerre, Christiana M., Sanatkar, Seyed-Amir, Burdorf, Lars, Ayares, David L., Eyestone, William, Sardana, Prachi, Kuravi, Kasinath, Sorrells, Lori, Lederman, Seth, Lucas, Caroline G., Prather, Randall S., Wells, Kevin D., Whitworth, Kristin M., Cooper, David K.C., and Pierson, Richard N., III

Published
2024
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15. TNX-1500, a crystallizable fragment–modified anti-CD154 antibody, prolongs nonhuman primate renal allograft survival

Author

Lassiter, Grace, Otsuka, Ryo, Hirose, Takayuki, Rosales, Ivy, Karadagi, Ahmad, Tomosugi, Toshihide, Dehnadi, Abbas, Lee, Hang, Colvin, Robert B., Baardsnes, Jason, Moraitis, Anna, Smith, Emma E., Ali, Zahida, Berhe, Phil, Mulder, Andrew, Meibohm, Bernd, Daugherty, Bruce, Fogarty, Siobhan, Pierson, Richard N., Lederman, Seth, and Kawai, Tatsuo

Published
2023
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18. Bioengineered omental transplant site promotes pancreatic islet allografts survival in non-human primates

Author

Deng, Hongping, Zhang, Alexander, Pang, Dillon Ren Rong, Xi, Yinsheng, Yang, Zhihong, Matheson, Rudy, Li, Guoping, Luo, Hao, Lee, Kang M., Fu, Qiang, Zou, Zhongliang, Chen, Tao, Wang, Zhenjuan, Rosales, Ivy A., Peters, Cole W., Yang, Jibing, Coronel, María M., Yolcu, Esma S., Shirwan, Haval, García, Andrés J., Markmann, James F., and Lei, Ji

Published
2023
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21. Molecular MR Imaging of Renal Fibrogenesis in Mice

Author

Chen, Yinching Iris, Waghorn, Philip A., Rosales, Ivy A., Arora, Gunisha, Erstad, Derek J., Rotile, Nicholas J., Jones, Chloe M., Ferreira, Diego S., Wei, Lan, Martinez, Robert V. P., Schlerman, Franklin J., Wellen, Jeremy, Fuchs, Bryan C., Colvin, Robert B., Ay, Ilknur, and Caravan, Peter

Published
2023
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23. Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis

Author

Moledina, Dennis G., Obeid, Wassim, Smith, Rex N., Rosales, Ivy, Sise, Meghan E., Moeckel, Gilbert, Kashgarian, Michael, Kuperman, Michael, Campbell, Kirk N., Lefferts, Sean, Meliambro, Kristin, Bitzer, Markus, Perazella, Mark A., Luciano, Randy L., Pober, Jordan S., Cantley, Lloyd G., Colvin, Robert B., Wilson, F. Perry, and Parikh, Chirag R.

Subjects
Nephritis -- Diagnosis -- Development and progression, Biological markers -- Physiological aspects -- Health aspects -- Identification and classification, Chemokines -- Physiological aspects -- Health aspects -- Identification and classification, Health care industry
Abstract

BACKGROUND. Acute tubulointerstitial nephritis (AIN) is one of the few causes of acute kidney injury with diagnosis- specific treatment options. However, due to the need to obtain a kidney biopsy for histological confirmation, AIN diagnosis can be delayed, missed, or incorrectly assumed. Here, we identify and validate urinary CXCL9, an IFN-[gamma]-induced chemokine involved in lymphocyte chemotaxis, as a diagnostic biomarker for AIN. METHODS. In a prospectively enrolled cohort with pathologist-adjudicated histological diagnoses, termed the discovery cohort, we tested the association of 180 immune proteins measured by an aptamer- based assay with AIN and validated the top protein, CXCL9, using sandwich immunoassay. We externally validated these findings in 2 cohorts with biopsy- confirmed diagnoses, termed the validation cohorts, and examined mRNA expression differences in kidney tissue from patients with AIN and individuals in the control group. RESULTS. In aptamer-based assay, urinary CXCL9 was 7.6-fold higher in patients with AIN than in individuals in the control group (P = 1.23 * [10.sup.-5]). Urinary CXCL9 measured by sandwich immunoassay was associated with AIN in the discovery cohort (n = 204; 15% AIN) independently of currently available clinical tests for AIN (adjusted odds ratio for highest versus lowest quartile: 6.0 [1.8-20]). Similar findings were noted in external validation cohorts, where CXCL9 had an AUC of 0.94 (0.86-1.00) for AIN diagnosis. CXCL9 mRNA expression was 3.9-fold higher in kidney tissue from patients with AIN (n = 19) compared with individuals in the control group (n = 52; P = 5.8 * [10.sup.-6]). CONCLUSION. We identified CXCL9 as a diagnostic biomarker for AIN using aptamer- based urine proteomics, confirmed this association using sandwich immunoassays in discovery and external validation cohorts, and observed higher expression of this protein in kidney biopsies from patients with AIN. FUNDING. This study was supported by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awards K23DK117065 (DGM), K08DK113281 (KM), R01DK128087 (DGM), R01DK126815 (DGM and LGC), R01DK126477 (KNC), UH3DK114866 (CRP, DGM, and FPW), R01DK130839 (MES), and P30DK079310 (the Yale O'Brien Center). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health., Introduction Sudden loss of kidney function, termed acute kidney injury (AKI), is common, affecting 1 in 5 hospitalized patients and is associated with adverse long-term outcomes, including chronic kidney disease, [...]

Published
2023
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24. Deep learning identified pathological abnormalities predictive of graft loss in kidney transplant biopsies

Author

Yi, Zhengzi, Salem, Fadi, Menon, Madhav C., Keung, Karen, Xi, Caixia, Hultin, Sebastian, Haroon Al Rasheed, M. Rizwan, Li, Li, Su, Fei, Sun, Zeguo, Wei, Chengguo, Huang, Weiqing, Fredericks, Samuel, Lin, Qisheng, Banu, Khadija, Wong, Germaine, Rogers, Natasha M., Farouk, Samira, Cravedi, Paolo, Shingde, Meena, Smith, R. Neal, Rosales, Ivy A., O’Connell, Philip J., Colvin, Robert B., Murphy, Barbara, and Zhang, Weijia

Published
2022
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25. Kidney transplantation from triple-knockout pigs expressing multiple human proteins in cynomolgus macaques

Author

Ma, David, Hirose, Takayuki, Lassiter, Grace, Sasaki, Hajime, Rosales, Ivy, Coe, Taylor M., Rickert, Charles G., Matheson, Rudy, Colvin, Robert B., Qin, Wenning, Kan, Yinan, Layer, Jacob V., Paragas, Violette B., Stiede, Kathryn, Hall, Katherine C., Youd, Michele E., Queiroz, Luis M., Westlin, William F., Curtis, Michael, Yang, Luhan, Markmann, James F., and Kawai, Tatsuo

Published
2022
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27. Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis

Author

Moledina, Dennis G., primary, Obeid, Wassim, additional, Smith, Rex N., additional, Rosales, Ivy, additional, Sise, Meghan E., additional, Moeckel, Gilbert, additional, Kashgarian, Michael, additional, Kuperman, Michael, additional, Campbell, Kirk N., additional, Lefferts, Sean, additional, Meliambro, Kristin, additional, Bitzer, Markus, additional, Perazella, Mark A., additional, Luciano, Randy L., additional, Pober, Jordan S., additional, Cantley, Lloyd G., additional, Colvin, Robert B., additional, Wilson, F. Perry, additional, and Parikh, Chirag R., additional

Published
2024
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28. A parathyroid hormone/salt-inducible kinase signaling axis controls renal vitamin D activation and organismal calcium homeostasis

Author

Yoon, Sung-Hee, Meyer, Mark B., Arevalo, Carlos, Tekguc, Murat, Zhang, Chengcheng, Wang, Jialiang S., Andrade, Christian D. Castro, Strauss, Katelyn, Sato, Tadatoshi, Benkusky, Nancy A., Lee, Seong Min, Berdeaux, Rebecca, Foretz, Marc, Sundberg, Thomas B., Xavier, Ramnik J., Adelmann, Charles H., Brooks, Daniel J., Anselmo, Anthony, Sadreyev, Ruslan I., Rosales, Ivy A., Fisher, David E., Gupta, Navin, Morizane, Ryuji, Greka, Anna, Pike, J. Wesley, Mannstad, Michael, and Wein, Marc N.

Subjects
Parathyroid hormone -- Health aspects, Gene expression -- Health aspects, Cellular signal transduction -- Health aspects, Bone diseases -- Genetic aspects -- Development and progression -- Care and treatment, Kidney diseases -- Genetic aspects -- Development and progression -- Care and treatment, Cytochrome P-450 -- Health aspects, Health care industry
Abstract

The renal actions of parathyroid hormone (PTH) promote 1,25-vitamin D generation; however, the signaling mechanisms that control PTH-dependent vitamin D activation remain unknown. Here, we demonstrated that salt-inducible kinases (SIKs) orchestrated renal 1,25-vitamin D production downstream of PTH signaling. PTH inhibited SIK cellular activity by cAMP-dependent PKA phosphorylation. Whole-tissue and single-cell transcriptomics demonstrated that both PTH and pharmacologic SIK inhibitors regulated a vitamin D gene module in the proximal tubule. SIK inhibitors increased 1,25-vitamin D production and renal Cyp27b1 mRNA expression in mice and in human embryonic stem cell-derived kidney organoids. Global- and kidney-specific Sik2/Sik3 mutant mice showed Cyp27b1 upregulation, elevated serum 1,25- vitamin D, and PTH-independent hypercalcemia. The SIK substrate CRTC2 showed PTH and SIK inhibitor-inducible binding to key Cyp27b1 regulatory enhancers in the kidney, which were also required for SIK inhibitors to increase Cyp27b1 in vivo. Finally, in a podocyte injury model of chronic kidney disease-mineral bone disorder (CKD-MBD), SIK inhibitor treatment stimulated renal Cyp27b1 expression and 1,25-vitamin D production. Together, these results demonstrated a PTH/SIK/CRTC signaling axis in the kidney that controls Cyp27b1 expression and 1,25-vitamin D synthesis. These findings indicate that SIK inhibitors might be helpful for stimulation of 1,25-vitamin D production in CKD-MBD., Introduction Vitamin D plays a critical role in bone and mineral metabolism and also controls other physiologic and pathophysiologic processes, including skeletal muscle function, reproductive health, cancer risk and progression, [...]

Published
2023
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30. The Banff 2022 Kidney Meeting Work Plan:Data-driven refinement of the Banff Classification for renal allografts

Author

Roufosse, Candice, Naesens, Maarten, Haas, Mark, Lefaucheur, Carmen, Mannon, Roslyn B., Afrouzian, Marjan, Alachkar, Nada, Aubert, Olivier, Bagnasco, Serena M., Batal, Ibrahim, Bellamy, Chris O.C., Broecker, Verena, Budde, Klemens, Clahsen-Van Groningen, Marian, Coley, Shana M., Cornell, Lynn D., Dadhania, Darshana, Demetris, Anthony J., Einecke, Gunilla, Farris, Alton B., Fogo, Agnes B., Friedewald, John, Gibson, Ian W., Horsfield, Catherine, Huang, Edmund, Husain, Syed A., Jackson, Annette M., Kers, Jesper, Kikić, Željko, Klein, Amanda, Kozakowski, Nicolas, Liapis, Helen, Mangiola, Massima, Montgomery, Robert A., Nankinvell, Brian, Neil, Desley A.H., Nickerson, Peter, Rabant, Marion, Randhawa, Parmjeet, Riella, Leonardo V., Rosales, Ivy, Royal, Virginie, Sapir-Pichhadze, Ruth, Sarder, Pinaki, Sarwal, Minnie, Schinstock, Carrie, Stegall, Mark, Solez, Kim, van der Laak, Jeroen, Wiebe, Chris, Colvin, Robert B., Loupy, Alexandre, Mengel, Michael, Roufosse, Candice, Naesens, Maarten, Haas, Mark, Lefaucheur, Carmen, Mannon, Roslyn B., Afrouzian, Marjan, Alachkar, Nada, Aubert, Olivier, Bagnasco, Serena M., Batal, Ibrahim, Bellamy, Chris O.C., Broecker, Verena, Budde, Klemens, Clahsen-Van Groningen, Marian, Coley, Shana M., Cornell, Lynn D., Dadhania, Darshana, Demetris, Anthony J., Einecke, Gunilla, Farris, Alton B., Fogo, Agnes B., Friedewald, John, Gibson, Ian W., Horsfield, Catherine, Huang, Edmund, Husain, Syed A., Jackson, Annette M., Kers, Jesper, Kikić, Željko, Klein, Amanda, Kozakowski, Nicolas, Liapis, Helen, Mangiola, Massima, Montgomery, Robert A., Nankinvell, Brian, Neil, Desley A.H., Nickerson, Peter, Rabant, Marion, Randhawa, Parmjeet, Riella, Leonardo V., Rosales, Ivy, Royal, Virginie, Sapir-Pichhadze, Ruth, Sarder, Pinaki, Sarwal, Minnie, Schinstock, Carrie, Stegall, Mark, Solez, Kim, van der Laak, Jeroen, Wiebe, Chris, Colvin, Robert B., Loupy, Alexandre, and Mengel, Michael

Abstract

The XVIth Banff Meeting for Allograft Pathology was held in Banff, Alberta, Canada, from September 19 to 23, 2022, as a joint meeting with the Canadian Society of Transplantation. In addition to a key focus on the impact of microvascular inflammation and biopsy-based transcript analysis on the Banff Classification, further sessions were devoted to other aspects of kidney transplant pathology, in particular T cell–mediated rejection, activity and chronicity indices, digital pathology, xenotransplantation, clinical trials, and surrogate endpoints. Although the output of these sessions has not led to any changes in the classification, the key role of Banff Working Groups in phrasing unanswered questions, and coordinating and disseminating results of investigations addressing these unanswered questions was emphasized. This paper summarizes the key Banff Meeting 2022 sessions not covered in the Banff Kidney Meeting 2022 Report paper and also provides an update on other Banff Working Group activities relevant to kidney allografts.

Published
2024

31. 414.1: Long-term (>1 Year) Rejection/TMA Free Survival of Kidney Xenografts With Triple Xenoantigen Knockout and Multiple Human Transgenes in Nonhuman Primates

Author

Lassiter, Grace, Hirose, Takayuki, Ma, David, D’Attilio, Ashley, Rosales, Ivy, Matheson, Rudy, Cloonan, Daniel, Colvin, Robert B., Qin, Wenning, Kan, Yinan, Layer, Jacob, Anand, Ranjith, Paragas, Violette, Queroz, Luis, Tan, Xiaoqing, Kohnle, Ian, Stiede, Katherine, Hall, Katherine, Youd, Michele, Curtis, Michael, Markmann, James F., and Kawai, Tatsuo

Published
2022
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37. Machine Perfusion Enables 24-h Preservation of Vascularized Composite Allografts in a Swine Model of Allotransplantation.

Author

Goutard, Marion, Tawa, Pierre, Berkane, Yanis, Andrews, Alec R., Pendexter, Casie A., de Vries, Reinier J., Pozzo, Victor, Romano, Golda, Lancia, Hyshem H., von Reiterdank, Irina Filz, Bertheuil, Nicolas, Rosales, Ivy A., How, Ira Doressa Anne L., Randolph, Mark A., Lellouch, Alexandre G., Cetrulo Jr., Curtis L., and Uygun, Korkut

Subjects
PRESERVATION of organs, tissues, etc., HOMOGRAFTS, PERFUSION, SWINE, COLD storage
Abstract

The current gold standard for preserving vascularized composite allografts (VCA) is 4°C static cold storage (SCS), albeit muscle vulnerability to ischemia can be described as early as after 2 h of SCS. Alternatively, machine perfusion (MP) is growing in theworld of organ preservation. Herein, we investigated the outcomes of oxygenated acellular subnormothermic machine perfusion (SNMP) for 24-h VCA preservation before allotransplantation in a swine model. Six partial hindlimbs were procured on adult pigs and preserved ex vivo for 24 h with either SNMP (n = 3) or SCS (n = 3) before heterotopic allotransplantation. Recipient animals received immunosuppression and were followed up for 14 days. Clinical monitoring was carried out twice daily, and graft biopsies and blood samples were regularly collected. Two blinded pathologists assessed skin and muscle samples. Overall survival was higher in the SNMP group. Early euthanasia of 2 animals in the SCS group was linked to significant graft degeneration. Analyses of the grafts showed massive muscle degeneration in the SCS group and a normal aspect in the SNMP group 2 weeks after allotransplantation. Therefore, this 24-h SNMP protocol using a modified Steen solution generated better clinical and histological outcomes in allotransplantation when compared to time-matched SCS. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Novel factors potentially initiating acute antibody‐mediated rejection in pig kidney xenografts despite an efficient immunosuppressive regimen.

Author

Kinoshita, Kohei, Maenaka, Akihiro, Rosales, Ivy A., Karadagi, Ahmad, Tomosugi, Toshihide, Ayares, David, Lederman, Seth, Colvin, Robert B., Kawai, Tatsuo, Pierson, Richard N., Kobayashi, Takaaki, and Cooper, David K. C.

Subjects
GRAFT rejection, XENOGRAFTS, TRANSPLANTATION of organs, tissues, etc., KIDNEY transplantation, KIDNEYS, DIABETIC nephropathies, PURE red cell aplasia
Abstract

Antibody‐mediated rejection (AMR) is a common cause of graft failure after pig‐to‐nonhuman primate organ transplantation, even when the graft is from a pig with multiple genetic modifications. The specific factors that initiate AMR are often uncertain. We report two cases of pig kidney transplantation into immunosuppressed baboons in which we identify novel factors associated with the initiation of AMR. In the first, membranous nephropathy was the initiating factor that was then associated with the apparent loss of the therapeutic anti‐CD154 monoclonal antibody in the urine when severe proteinuria was present. This observation suggests that proteinuria may be associated with the loss of any therapeutic monoclonal antibody, for example, anti‐CD154 or eculizumab, in the urine, resulting in xenograft rejection. In the second case, the sequence of events and histopathology tentatively suggested that pyelonephritis may have initiated acute‐onset AMR. The association of a urinary infection with graft rejection has been well‐documented in ABO‐incompatible kidney allotransplantation based on the expression of an antigen on the invading microorganism shared with the kidney graft, generating an immune response to the graft. To our knowledge, these potential initiating factors of AMR in pig xenografts have not been highlighted previously. [ABSTRACT FROM AUTHOR]

Published
2024
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39. The Banff 2022 Kidney Meeting Work Plan: Data-driven refinement of the Banff Classification for renal allografts

Author

Roufosse, Candice, primary, Naesens, Maarten, additional, Haas, Mark, additional, Lefaucheur, Carmen, additional, Mannon, Roslyn B., additional, Afrouzian, Marjan, additional, Alachkar, Nada, additional, Aubert, Olivier, additional, Bagnasco, Serena M., additional, Batal, Ibrahim, additional, Bellamy, Chris O.C., additional, Broecker, Verena, additional, Budde, Klemens, additional, Clahsen-Van Groningen, Marian, additional, Coley, Shana M., additional, Cornell, Lynn D., additional, Dadhania, Darshana, additional, Demetris, Anthony J., additional, Einecke, Gunilla, additional, Farris, Alton B., additional, Fogo, Agnes B., additional, Friedewald, John, additional, Gibson, Ian W., additional, Horsfield, Catherine, additional, Huang, Edmund, additional, Husain, Syed A., additional, Jackson, Annette M., additional, Kers, Jesper, additional, Kikić, Željko, additional, Klein, Amanda, additional, Kozakowski, Nicolas, additional, Liapis, Helen, additional, Mangiola, Massima, additional, Montgomery, Robert A., additional, Nankinvell, Brian, additional, Neil, Desley A.H., additional, Nickerson, Peter, additional, Rabant, Marion, additional, Randhawa, Parmjeet, additional, Riella, Leonardo V., additional, Rosales, Ivy, additional, Royal, Virginie, additional, Sapir-Pichhadze, Ruth, additional, Sarder, Pinaki, additional, Sarwal, Minnie, additional, Schinstock, Carrie, additional, Stegall, Mark, additional, Solez, Kim, additional, van der Laak, Jeroen, additional, Wiebe, Chris, additional, Colvin, Robert B., additional, Loupy, Alexandre, additional, and Mengel, Michael, additional

Published
2023
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40. Response Regarding: Continuous Versus Pulsatile Flow in 24-h Vascularized Composite Allograft Machine Perfusion in Swine: A Pilot Study

Author

Tawa, Pierre, primary, Goutard, Marion, additional, Andrews, Alec R., additional, de Vries, Reinier J., additional, Rosales, Ivy A., additional, Yeh, Heidi, additional, Uygun, Basak, additional, Randolph, Mark A., additional, Lellouch, Alexandre G., additional, Uygun, Korkut, additional, and Cetrulo, Curtis L., additional

Published
2023
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41. Gadolinium-based Contrast Agent Biodistribution and Speciation in Rats

Author

Le Fur, Mariane, primary, Moon, Brianna F., additional, Zhou, Iris Y., additional, Zygmont, Samantha, additional, Boice, Avery, additional, Rotile, Nicholas J., additional, Ay, Ilknur, additional, Pantazopoulos, Pamela, additional, Feldman, Adam S., additional, Rosales, Ivy A., additional, How, Ira Doressa Anne L., additional, Izquierdo-Garcia, David, additional, Hariri, Lida P., additional, Astashkin, Andrei V., additional, Jackson, Brian P., additional, and Caravan, Peter, additional

Published
2023
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45. Increased human complement pathway regulatory protein gene dose is associated with increased endothelial expression and prolonged survival during ex‐vivo perfusion of GTKO pig lungs with human blood

Author

Chaban, Ryan, primary, McGrath, Gannon, additional, Habibabady, Zahra, additional, Rosales, Ivy, additional, Burdorf, Lars, additional, Ayares, David L., additional, Rybak, Elana, additional, Zhang, Tianshu, additional, Harris, Donald G., additional, Dahi, Siamak, additional, Ali, Franchesca, additional, Parsell, Dawn M., additional, Braileanu, Gheorghe, additional, Cheng, Xiangfei, additional, Sievert, Evelyn, additional, Phelps, Carol, additional, Azimzadeh, Agnes M., additional, and Pierson, Richard N., additional

Published
2023
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