196 results on '"Rosa Pardo"'
Search Results
2. Bifurcation from infinity with oscillatory nonlinearity for Neumann problems
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Maya Chhetri, Nsoki Mavinga, and Rosa Pardo
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bifurcation from infinity ,oscillatory nonlinearity ,turning points ,neumann boundary condition ,resonant solutions ,Mathematics ,QA1-939 - Published
- 2022
3. Asymptotic behavior of positive radial solutions to elliptic equations approaching critical growth
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Rosa Pardo and Arturo Sanjuan
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a priori bounds ,positive solutions ,semilinear elliptic equations ,dirichlet boundary conditions ,growth estimates ,subcritical nonlinearites ,Mathematics ,QA1-939 - Abstract
We study the asymptotic behavior of radially symmetric solutions to the subcritical semilinear elliptic problem $$\displaylines{ -\Delta u = u^{\frac{N+2}{N-2}}/[\log(e+u)]^{\alpha}\quad \text{in } \Omega=B_R(0)\subset\mathbb{R}^N,\cr u>0,\quad \text{in } \Omega,\cr u=0,\quad \text{on } \partial \Omega, }$$ as $\alpha\to 0^+$. Using asymptotic estimates, we prove that there exists an explicitly defined constant L(N,R)>0, only depending on N and R, such that $$ \limsup_{\alpha\to0^+} \frac{\alpha u_\alpha (0)^2} {[\log(e+u_\alpha (0))]^{1+\frac{\alpha(N+2)}{2}}} \leq L(N,R) \le 2^*\liminf_{\alpha\to0^+}\frac{\alpha u_\alpha (0)^2} {[\log(e+u_\alpha (0))]^{\frac{\alpha(N-4)}2}}. $$
- Published
- 2020
4. Prevalence of microcephaly: the Latin American Network of Congenital Malformations 2010–2017
- Author
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Helen Dolk, Boris Groisman, Joan Morris, Rosa Pardo, Elizabeth Limb, Iêda M Orioli, Adriana Benavides-Lara, María de la Paz Barboza-Arguello, Maria Aurora Canessa Tapia, Giovanny Vinícius Araújo de França, Jorge Holguin, Paula Margarita Hurtado-Villa, Marisol Ibarra Ramirez, Cecilia Mellado, Dania Maria Pastora Bucardo, Catherin Rodríguez, and Ignacio Zarante
- Subjects
Pediatrics ,RJ1-570 - Abstract
Objective The Latin American Network of Congenital Malformations: ReLAMC was established in 2017 to provide accurate congenital anomaly surveillance. This study used data from ReLAMC registries to quantify the prevalence of microcephaly from 2010 to 2017 (before, during and after the Zika virus epidemic).Design Nine ReLAMC congenital anomaly registries provided case-level data or aggregate data for any live births, still births or terminations of pregnancy with microcephaly. Births to pregnant women infected with Zika virus first occurred in Brazil in 2015, and in the remaining registry areas in 2016 with the exception of Chile that did not experience Zika virus. Therefore the prevalence of microcephaly for 2010–2014 and individual years 2015, 2016 and 2017 was estimated using multilevel random effect Poisson models. Clinical classification and characteristics of the cases were compared pre and post Zika for all centres providing individual case-level data.Results The prevalence of microcephaly for all registries excluding Brazil was 2.3 per 10 000 (95% CI 2.0 to 2.6) for 2010–2014 rising to 5.4 (95% CI 4.8 to 6.0) in 2016 and 5.9 (95% CI 5.3 to 6.6) in 2017. Brazil had a prevalence of 0.6 per 10 000 (95% CI 0.5 to 0.6) in 2010–2014, rising to 5.8 (95% CI 5.6 to 6.1) in 2015, 8.0 (95% CI 7.6 to 8.3) in 2016 and then falling in 2017. Only 29 out of 687 cases of microcephaly were reported as congenital Zika syndrome in countries excluding Brazil.Conclusions The prevalence of microcephaly was influenced both by Zika causing congenital Zika syndrome and by increased reporting awareness.
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- 2021
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5. COVID-19 in a cohort of pregnant women and their descendants, the MOACC-19 study
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Jessica Alonso-Molero, Javier Llorca, Carolina Lechosa-Muñiz, Pilar Gortazar, María Fernández-Ortiz, Yolanda Jubete, Maria J Cabero, Bárbara Arozamena, Laura Conde-Gil, Elsa Cornejo del Río, Rocío Cuesta-González, Trinidad Dierssen-Sotos, Pelayo Frank de Zulueta, Inés Gómez-Acebo, Coral Llano-Ruiz, Lorena Lasarte-Oria, Sonia López-Gómez, Sonia Mateo-Sota, Victoria Orallo, Rosa Pardo, Daniel Pérez González, and María Sáez de Adana Herrero
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Medicine - Abstract
Purpose The Mother and Child COVID-19 study is a cohort recruiting pregnant women and their children in Cantabria, North of Spain, during COVID-19 pandemic in order to ascertain consequences of SARS-CoV-2 infection on pregnant women and their descendants. This article reports the cohort profile and preliminary results as recruitment is still open.Participants Three subcohorts can be identified at recruitment. Subcohort 1 includes women giving birth between 23 March and 25 May 2020; they have been retrospectively recruited and could have been exposed to COVID-19 only in their third trimester of pregnancy. Subcohort 2 includes women giving birth from 26 May 2020 on; they are being prospectively recruited and could have been exposed to COVID-19 in both their second and third trimesters of pregnancy. Subcohort 3 includes women in their 12 week of pregnancy prospectively recruited from 26 May 2020 on; they could have been exposed to COVID-19 anytime in their pregnancy. All women are being tested for SARS-CoV-2 infection using both RT-PCR for RNA detection and ELISA for anti-SARS-CoV-2 antibodies. All neonates are being tested for antibodies using immunochemoluminiscency tests; if the mother is tested positive for SARS-CoV-2 RNA, a nasopharyngeal swab is also obtained from the child for RT-PCR analysis.Findings to date As of 22 October, 1167 women have been recruited (266, 354 and 547 for subcohorts 1, 2 and 3, respectively). Fourteen women tested positive to SARS-CoV-2 RNA by the day of delivery. All 14 children born from these women tested negative for SARS-CoV-2 RNA.Future plans Children from women included in subcohort 3 are expected to be recruited by the end of 2020. Children will be followed-up for 1 year in order to ascertain the effect that COVID-19 on their development.
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- 2021
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6. Public attitudes toward biodiversity‐friendly greenspace management in Europe
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Leonie K. Fischer, Lena Neuenkamp, Jussi Lampinen, Maria Tuomi, Josu G. Alday, Anna Bucharova, Laura Cancellieri, Izaskun Casado‐Arzuaga, Natálie Čeplová, Lluïsa Cerveró, Balázs Deák, Ove Eriksson, Mark D. E. Fellowes, Beatriz Fernández de Manuel, Goffredo Filibeck, Adrián González‐Guzmán, M. Belen Hinojosa, Ingo Kowarik, Belén Lumbierres, Ana Miguel, Rosa Pardo, Xavier Pons, Encarna Rodríguez‐García, Roland Schröder, Marta Gaia Sperandii, Philipp Unterweger, Orsolya Valkó, Víctor Vázquez, and Valentin H. Klaus
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biodiversity conservation ,biodiversity‐friendly greenspace management ,environmental education ,environmental policy ,environmental responsibility ,lawn alternative ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
Abstract Increasing urbanization worldwide calls for more sustainable urban development. Simultaneously, the global biodiversity crisis accentuates the need of fostering biodiversity within cities. Policies supporting urban nature conservation need to understand people's acceptance of biodiversity‐friendly greenspace management. We surveyed more than 2,000 people in 19 European cities about their attitudes toward near‐natural urban grassland management in public greenspaces, and related their responses to nine sociocultural parameters. Results reveal that people across Europe can support urban biodiversity, yet within the frames of a generally tidy appearance of public greenery. Younger people and those using greenspaces for a greater variety of activities were more likely to favor biodiversity‐friendly greenspace management. Additionally, people who were aware of the meaning of biodiversity and those stating responsibility for biodiversity conservation particularly supported biodiversity‐friendly greenspace management. Our results point at explicit measures like environmental education to increase public acceptance of policies that facilitate nature conservation within cities.
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- 2020
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7. Morten Heiberg, U.S.-Spanish relations after Franco, 1975-1989. The will of the weak
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Rosa Pardo
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History of Spain ,DP1-402 ,Latin America. Spanish America ,F1201-3799 ,French literature - Italian literature - Spanish literature - Portuguese literature ,PQ1-3999 - Published
- 2020
8. Washhouses where women wash. A contradictory and diffuse space in urban policies
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Carlos Barberá Pastor and Rosa Pardo Marín
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políticas urbanas ,mujeres ,agua ,lavaderos ,The family. Marriage. Woman ,HQ1-2044 ,Women. Feminism ,HQ1101-2030.7 - Abstract
The globalization process, characterised by major worldwide interrelation and dependency, is entailing increasingly uniform economic, technological and cultural aspects. Territory nevertheless continues to be a different reality in each part of the planet due to natural factors (geomorphology, soil or climate), but also to human practices transforming this to adapt to local needs and circumstances. Each area thus generates diverse life experiences whose memory is reflected in the landscape, in urban areas or heritage, giving each place its specific character and identity. One of the determining factors in forming the landscape is water and it seems a universal fact that women are assigned many tasks involving water. In this curious interrelation between global and local spheres the study of washhouses is used for comprehensively characterising a particular landscape but with a specific use of space than concerns women’s work conditions and memory. The New Urban Agenda could provide a better sustainable urbanization linked with that.
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- 2018
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9. Gènere i diversitat sexual en la literatura infantil valenciana del segle XXI: una anàlisi dels materials literaris a l’aula d’educació infantil
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Miquel A. Oltra-Albiach and Rosa Pardo-Coy
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diversitat sexual ,literatura infantil ,gènere ,anàlisi de materials ,didàctica de la literatura ,French literature - Italian literature - Spanish literature - Portuguese literature ,PQ1-3999 ,Social sciences (General) ,H1-99 - Abstract
This research starts out from an educational perspective: as literature a teachers in a Teacher Training College, we have noted the lack of diversity in family patterns in the text books. We have also observed how various stereotypes related to gender roles within families, jobs or the way in which gender itself expresses, are still present in the texts that schools offer to beginning readers. In this paper, we approach the Valencian literature for beginning readers in order to analyze the family structures and the treatment of roles of its members in various literary genres from books targeted at pre-school education (five years).
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- 2017
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10. A mathematical model for the use of energy resources: a singular parabolic equation
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Daniel López-García and Rosa Pardo
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singular parabolic equation ,degenerate parabolic equations ,existence ,uniqueness ,symmetric boundary layer ,regularity ,Mathematics ,QA1-939 - Abstract
We consider a singular parabolic equation, for , arising in symmetric boundary layer flows. Here is a bounded domain with C2 boundary is bounded, and T > 0 is some fixed time. We establish sufficient conditions for the existence and uniqueness of a weak solution of this singular parabolic equation with Dirichlet boundary conditions, and we investigate its regularity. There are two different cases depending on β. If β < 1, for any initial data, there exists a unique weak solution, which in fact is a strong solution. The singularity is removable when β < 1. While if β = 1, there exists a unique solution of the singular parabolic problem The initial data cannot be arbitrarily chosen. In fact, if f is continuous and , as t → 0, then, this solution converges, as t → 0, to the solution of the elliptic problem, for , with Dirichlet boundary conditions. Hence, no initial data can be prescribed when β = 1, and the singularity in that case is strong.
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- 2020
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11. On the existence of a priori bounds for positive solutions of elliptic problems, II
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Rosa Pardo
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A priori estimates ,subcritical nonlinearity ,moving planes method ,Pohozaev identity ,critical Sobolev hyperbola ,biparameter bifurcation ,Mathematics ,QA1-939 - Abstract
We continue studying the existence of uniform L∞ a priori bounds for positive solutions of subcritical elliptic equations (P)p − \Delta_pu = f(u), in \Omega, u = 0, on ∂\Omega, We provide sufficient conditions for having a-priori L∞ bounds for C1,μ (\overline{\Omega }) positive solutions to a class of subcritical elliptic problems in bounded, convex, C2 domains. In this part II, we extend our results to Hamiltonian elliptic systems −\Delta u = f(v),−\Deltav = g(u), in \Omega, u = v = 0 on ∂\Omega, when f(v) = vp /[ln(e + v)]α, g(u) = uq/[ln(e + u)]β, with α, β > 2/(N − 2), and p, q are lying in the critical Sobolev hyperbolae 1/p+1 + 1/q+1 = N−2/N . For quasilinear elliptic equations involving the p-Laplacian, there exists a-priori bounds for positive solutions of (P)p when f(u) = up⋆−1/[ln(e + u)]α, with p∗ = Np/(N−p), and α > p/(N−p). We also study the asymptotic behavior of radially symmetric solutions uα = uα(r) of (P)2 as α → 0.
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- 2019
12. Patrón de ingesta alimentaria en la primera infancia en una cohorte de lactantes del norte de España
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Laura Monje Pardo, Rosa Pardo Crespo, Elena Güemes, Reyes Mazas, Irene Castro, Carmen Rodríguez, Luis Fernández, and María Jesús Cabrero
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Nutrition. Foods and food supply ,TX341-641 ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
II Congreso de Alimentación, Nutrición y Dietética. Avances en Nutrición y Dietética Clínica: Prevención, Tratamiento y Gestión - Rol del Dietista-Nutricionista
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- 2018
13. Bifurcation for an elliptic problem with nonlinear boundary conditions
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Rosa Pardo
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Bifurcation from infinity ,stability ,instability ,multiplicity ,resonance ,turning points ,Bifurcación en el infinito ,estabilidad ,inestabilidad ,multiplicidad ,resonancia ,puntos de inflexión ,Mathematics ,QA1-939 - Abstract
This paper gives a survey over bifurcation problems for elliptic equations with nonlinear boundary conditions depending on a real parameter. We consider an elliptic equation with a nonlinear boundary condition which is asymptotically linear at infinity and which depends on a parameter. As the parameter crosses some critical values, there appear certain resonances in the equation producing solutions that bifurcate from infinity. We study the bifurcation branches, and characterize when they are sub- or supercritical. Furthermore, we apply these results and techniques to obtain Landesman-Lazer type conditions guarantying the existence of solutions in the resonant case and to obtain a uniform Anti-Maximum Principle and several results related to the spectral behavior when the potential at the boundary is perturbed. We also characterize the stability type of the solutions in the unbounded branches. In the remainder of this paper, we start our analysis on a sublinear oscillatory nonlinearity. We first focus our attention on the loss of Landesman-Lazer type conditions, and even in that situation, we are able to prove the existence of infinitely many resonant solutions and infinitely many turning points. Next we focus our attention on stability switches. Even in the absence of resonant solutions, we are able to provide sufficient conditions for the existence of sequences of stable solutions, unstable solutions, and turning points. We also discuss on bifurcation from the trivial solution set, and on a sublinear oscillatory nonlinearity. Finally, we states a formula for the derivative of a localized Steklov eigenvalue on a subset of the boundary, with respect to tangential variations of that subset. Resumen. Este artículo presenta un estudio sobre bifurcación para problemas elípticos con condiciones de frontera no-lineales. Consideramos una ecuación elíptica con condiciones de frontera no-lineales dependiendo de un parámetro. Supondremos que el término no lineal es asintóticamente lineal en el infinito. Cuando el parámetro cruza ciertos valores críticos (conocidos como los autovalores de Steklov) aparece un fenómeno de resonancia en la ecuación, lo que garantiza la existencia de ramas no acotadas de soluciones. Este fenómeno se conoce como bifurcación desde infinito. Estudiamos las ramas de soluciones y caracterizamos cuando son subcríticas (a la izquierda del autovalor) o supercríticas (a la derecha del autovalor). Aplicamos estos resultados para obtener condiciones del tipo Landesman-Lazer, que garantizan la existencia de soluciones para el problema resonante (cuando el parámetro coincide con el autovalor). Obtenemos también un Principio del Anti-Máximo, y resultados relativos al comportamiento espectral, cuando se perturba el potencial en la frontera. Además caracterizamos el tipo de estabilidad de las soluciones en dichas ramas no acotadas. En el resto del articulo, analizamos no linealidades oscilatorias y sublineales. Centramos nuestra atención en la pérdida de condiciones del tipo LandesmanLazer. Incluso en esta situación, demostramos la existencia de una sucesión de infinitas soluciones del problema resonante y una sucesión de infinitos puntos de retroceso. A continuación, analizamos los cambios de estabilidad. Incluso en ausencia de soluciones resonantes, proporcionamos condiciones suficientes para la existencia de una sucesión de infinitas soluciones estables, una sucesión de infinitas soluciones inestables y una sucesión de infinitos puntos de retroceso. También analizamos la bifurcación desde la solución trivial con una nolinealidad de tipo sublineal y oscilatorio. Finalmente establecemos una fórmula para la derivada del autovalor de Steklov localizado sobre un subconjunto de la frontera, con respecto a variaciones tangenciales del subconjunto.
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- 2012
14. Four-parameter bifurcation for a p-Laplacian system
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Jacqueline Fleckinger, Rosa Pardo, and Francois De Thelin
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p-Laplacian ,bifurcation. ,Mathematics ,QA1-939 - Abstract
We study a four-parameter bifurcation phenomenum arising in a system involving $p$-Laplacians: $$displaylines{ -Delta_p u = a phi_p(u)+ b phi_p(v) + f(a , phi_p (u), phi_p (v)) ,cr -Delta_p v = c phi_p(u) + d phi{p}(v)) + g(d , phi_p (u), phi_p (v)), }$$ with $u=v=0$ on the boundary of a bounded and sufficiently smooth domain in $mathbb{R}^N$; here $Delta_{p}u = { m div} (| abla u|^{p-2} abla u)$, with $p>1$ and $p eq 2$, is the $p$-Laplacian operator, and $phi_{p} (s) =|s|^{p-2} s$ with $p>1$. We assume that $a, b, c, d$ are real parameters, and use a bifurcation method to exhibit some nontrivial solutions. The associated eigenvalue problem, with $f=g equiv 0$, is also studied here.
- Published
- 2001
15. Bifurcación para un problema elíptico con condiciones de frontera no lineales
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Rosa Pardo
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Bifurcación en el infinito ,estabilidad ,inestabilidad ,multiplicidad ,resonancia ,puntos de inflexión ,Mathematics ,QA1-939 - Abstract
Este artículo presenta un estudio sobre bifurcación para problemas elípticos con condiciones de frontera no-lineales. Consideramos una ecuación elíptica con condiciones de frontera no-lineales dependiendo de un parámetro. Supondremos que el término no lineal es asintóticamente lineal en el infinito. Cuando el parámetro cruza ciertos valores críticos (conocidos como los auto valores de Steklov) aparece un fenómeno de resonancia en la ecuación, lo que garantiza la existencia de ramas no acotadas de soluciones. Este fenómeno se conoce como bifurcación desde infinito. Estudiamos las ramas de soluciones y caracterizamos cuando son subcríticas (a la izquierda del autovalor) o supercríticas (a la derecha del autovalor). Aplicamos estos resultados para obtener condiciones del tipo Landesman-Lazer, que garantizan la existencia de soluciones para el problema resonante (cuando el parámetro coincide con el autovalor). Obtenemos también un Principio del Anti-Máximo, y resultados relativos al comportamiento espectral, cuando se perturba el potencial en la frontera. Además caracterizamos el tipo de estabilidad de las soluciones en dichas ramas no acotadas. En el resto del articulo, analizamos no linealidades oscilatorias y sublineales. Centramos nuestra atención en la pérdida de condiciones del tipo Landesman-Lazer. Incluso en esta situación, demostramos la existencia de una sucesión de infinitas soluciones del problema resonante y una sucesión de infinitos puntos de retroceso. A continuación, analizamos los cambios de estabilidad. Incluso en ausencia de soluciones resonantes, proporcionamos condiciones suficientes para la existencia de una sucesión de infinitas soluciones estables, una sucesión de infinitas soluciones inestables y una sucesión de infinitos puntos de retroceso. También analizamos la bifurcación desde la solución trivial con una no-linealidad de tipo sublineal y oscilatorio. Finalmente establecemos una fórmula para la derivada del autovalor de Steklov localizado sobre un subconjunto de la frontera, con respecto a variaciones tangenciales del subconjunto.
- Published
- 2012
16. Contributors
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Abdi, Yaser, primary, Ahmed, Irfan, additional, Ansari, Jamilur R., additional, Arulraj, A., additional, Behrouznejad, Fatemeh, additional, Besleaga, Cristina, additional, Brophy, Rachel Elizabeth, additional, Carmona-Monroy, Paulina, additional, Chandra, Amreesh, additional, Chen, Yonghua, additional, Chowdhury, Faisal Islam, additional, Chowdhury, Towhid H., additional, Cortés-Villena, Alejandro, additional, Cuzminschi, Marina, additional, Derbali, Sarah, additional, Filipoiu, Nicolae, additional, Florea, Mihaela, additional, Galian, Raquel E., additional, Gholipour, Somayeh, additional, Ghosh, Subrata, additional, Grandhi, G. Krishnamurthy, additional, Gussain, Meenakshi, additional, Hadadian, Mahboubeh, additional, Haider, Waseem, additional, Hatamvand, Mohammad, additional, Huang, Wei, additional, Jain, Neha, additional, Kansal, Sakshi, additional, Kateb, Movaffaq, additional, Khalid, Mohammad, additional, Kumar, Dinesh, additional, Liu, Maning, additional, Lu, Chung-Hsin, additional, Mangalaraja, R.V., additional, Manolescu, Andrei, additional, Mariyappan, Pandiyarajan, additional, Meena, Mohan Lal, additional, Mitran, Tudor Luca, additional, Naseh, Md. Farhan, additional, Nemnes, George Alexandru, additional, Pérez-Prieto, Julia, additional, Pintilie, Ioana, additional, Porwal, Shivam, additional, Priya, Surbhi, additional, Rahman, M. Atikur, additional, Rajkumar, C., additional, Roose, Bart, additional, Rosa-Pardo, Ignacio, additional, Sajedi Alvar, Mohammad, additional, Shyju, T.S., additional, Singh, Anupriya, additional, Singh, Rajan Kumar, additional, Singh, Trilok, additional, Solis-Ibarra, Diego, additional, Som, Sudipta, additional, Stancu, Viorica, additional, Sunilbhai, Choudhary Arjun, additional, Tamrakar, Radha, additional, Tomulescu, Andrei G., additional, Vargas, Brenda, additional, Vengatesh, P., additional, Vivo, Paola, additional, Yavari, Mozhgan, additional, and Zhan, Yiqiang, additional
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- 2023
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17. Synthesis techniques of metal halide perovskites
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Rosa-Pardo, Ignacio, primary, Cortés-Villena, Alejandro, additional, Galian, Raquel E., additional, and Pérez-Prieto, Julia, additional
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- 2023
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18. Contributors
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Abadingo, Michelle E., primary, Ascurra, Marta, additional, Bishop, Michelle, additional, Calzone, Kathleen, additional, Cutiongco-de la Paz, Eva Maria C., additional, Dissanayake, Vajira H.W., additional, El-Kamah, Ghada, additional, Fieggen, Karen, additional, Gaff, Clara L., additional, Johnson, Desalyn L., additional, Korf, Bruce R., additional, Kumar, Dhavendra, additional, de la Fuente, Beatriz, additional, Lynch, Elly, additional, Maceda, Ebner Bon G., additional, Mahmood, Saqib, additional, Martyn, Melissa, additional, Middleton, A., additional, Montenegro-Garreaud, Ximena, additional, Moresco, Angelica, additional, Mountain, Helen, additional, Nisselle, Amy, additional, Pachter, Nicholas, additional, Padilla, Carmencita D., additional, Puri, Ratna Dua, additional, Raggio, Victor, additional, Ramsden, Simon, additional, Roberts, J., additional, Rojas-Martinez, Augusto, additional, Seller, Anneke, additional, Taylor-Beadling, Alison, additional, Thakur, Nilam, additional, Tonkin, Emma, additional, and Vargas, Rosa Pardo, additional
- Published
- 2022
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19. Preparing the workforce for genomic medicine: International challenges and strategies
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Johnson, Desalyn L., primary, Korf, Bruce R., additional, Ascurra, Marta, additional, El-Kamah, Ghada, additional, Fieggen, Karen, additional, de la Fuente, Beatriz, additional, Mahmood, Saqib, additional, Rojas-Martinez, Augusto, additional, Montenegro-Garreaud, Ximena, additional, Moresco, Angelica, additional, Mountain, Helen, additional, Pachter, Nicholas, additional, Puri, Ratna Dua, additional, Raggio, Victor, additional, Thakur, Nilam, additional, and Vargas, Rosa Pardo, additional
- Published
- 2022
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20. Neural tube defects and epigenetics: role of histone post-translational histone modifications
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V, Rosa Pardo, primary, Finnell, Richard H, additional, Ross, M Elizabeth, additional, Alarcón, Pablo, additional, and Suazo, José, additional
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- 2024
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21. Photocatalytic activity of metal halide nanocrystals for C-C coupling reactions
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Galian, Raquel E., primary, Rosa Pardo, Ignacio, additional, and Pérez Prieto, Julia, additional
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- 2023
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22. LA LECTURA EN EL CONTEXTO ACADÉMICO
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Oltra-Albiach, Miquel A., primary, Coy, Rosa Pardo, additional, and Delgadová, Elena, additional
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- 2020
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23. Síndrome de quilomicronemia: aspectos genéticos y revisión de la literatura
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Ricardo Fuentes U. and Rosa Pardo V.
- Abstract
Chylomicronemia syndrome is a metabolic condition characterized by severe hypertriglyceridemia and fasting chylomicronemia, secondary to an alteration in the ability to metabolize triglycerides. It can respond to different etiologies, the most frequent being multifactorial. Familial chylomicronemia syndrome, on the other hand, represents an infrequent cause of chylomicronemia syndrome, showing an autosomal recessive inheritance pattern. It’s caused by pathogenic variants in genes related to chylomicron’s metabolism, mainly LPL1 gene. One of the main associated risks is the occurrence of acute pancreatitis, which can also have a recurrent course. The primary therapy goal in patients with this condition is prevention of pancreatitis and related comorbidities. The treatment basis consists in reduce chylomicron formation by restriction of dietary fat, in association with physical activity and pharmacologic therapy. It is important to distinguish the etiology of chylomicronemia syndrome since it has repercussions in terms of response to treatment, complications, and recurrence risk.
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- 2022
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24. PEMT variants are associated with nonsyndromic cleft lip with or without cleft palate in Chile
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José Suazo, Carlos Salamanca, Patricio González-Hormazábal, Gabriela Cáceres-Rojas, Roberto Pantoja, Noemi Leiva, and Rosa Pardo
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Cancer Research ,Genetics - Abstract
Aim: To assess the association between PEMT variants and nonsyndromic cleft lip with or without cleft palate in Chile and the effects of these variants on global DNA methylation. Subjects & methods: The authors obtained genotypes for nine variants from 247 cases and 453 controls for genotype–phenotype associations. The effect of significant polymorphisms on global DNA methylation (percentage of long interspersed element-1 methylation) was evaluated in a subsample of 95 controls. Results: After multiple comparison corrections, variants rs7649 and rs4646409 were associated with nonsyndromic cleft lip with or without cleft palate. Carriers of risk alleles presented lower DNA methylation levels than noncarriers. Conclusion: According to functional analysis for risk variants from previous reports, the authors infer that a decrease of methyl group availability is occurring in affected subjects.
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- 2022
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25. One-Pot Synthesis of Stable CsPbBr3@CsPb2Br5 Core–Shell Heteronanocrystals with Controlled Permeability to Halide Ions
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Rosa-Pardo, Ignacio, primary, Ciccone, Alessandro, additional, Arenal, Raúl, additional, Galian, Raquel E., additional, and Pérez-Prieto, Julia, additional
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- 2023
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26. Furthering US Geopolitical Priorities and Dealing with the Iberian Dictatorships
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Sanz, Rosa Pardo, Rodríguez Jiménez, Francisco Javier, editor, Gómez-Escalonilla, Lorenzo Delgado, editor, and Cull, Nicholas J., editor
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- 2015
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27. One-pot synthesis of stable CsPbBr3@CsPb2Br5 core-shell heteronanocrystals with controlled permeability to halide ions
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Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Ciencia e Innovación (España), European Commission, Agencia Estatal de Investigación (España), Gobierno de Aragón, Generalitat Valenciana, Diputación General de Aragón, Rosa-Pardo, Ignacio, Ciccone, Alessandro, Arenal, Raúl, Galian, Raquel E., Pérez-Prieto, Julia, Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Ciencia e Innovación (España), European Commission, Agencia Estatal de Investigación (España), Gobierno de Aragón, Generalitat Valenciana, Diputación General de Aragón, Rosa-Pardo, Ignacio, Ciccone, Alessandro, Arenal, Raúl, Galian, Raquel E., and Pérez-Prieto, Julia
- Abstract
A simple one-pot synthetic strategy based on the hot injection methodology was adapted to prepare (photo)stable and green emissive colloidal CsPbBr3@CsPb2Br5 core@shell heteronanocrystals (HNCs). The photoactive core, specifically CsPbBr3 ternary metal halide nanocrystals, was homogeneously covered with an ultrathin CsPb2Br5 shell (ca. 2 nm), which confers them with long-term stability and a higher photoluminescence quantum yield. Astonishingly, this heterostructure enabled controlled halide exchange to yield unprecedented CsPbCl3@CsPb2Cl5 and CsPbI3@CsPb2I5 HNCs.
- Published
- 2023
28. The Dark Side of Lead-Free Metal Halide Nanocrystals: Substituent-Modulated Photocatalytic Activity in Benzyl Bromide Reduction
- Author
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Rosa-Pardo, Ignacio, primary, Zhu, Dongxu, additional, Cortés-Villena, Alejandro, additional, Prato, Mirko, additional, De Trizio, Luca, additional, Manna, Liberato, additional, Galian, Raquel E., additional, and Pérez-Prieto, Julia, additional
- Published
- 2023
- Full Text
- View/download PDF
29. Positive Solutions for Slightly Subcritical Elliptic Problems Via Orlicz Spaces
- Author
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Mabel Cuesta and Rosa Pardo
- Subjects
Topología ,General Mathematics ,Mathematics::Analysis of PDEs - Abstract
This paper concerns semilinear elliptic equations involving sign-changing weight function and a nonlinearity of subcritical nature understood in a generalized sense. Using an Orlicz–Sobolev space setting, we consider superlinear nonlinearities which do not have a polynomial growth, and state sufficient conditions guaranteeing the Palais–Smale condition. We study the existence of a bifurcated branch of classical positive solutions, containing a turning point, and providing multiplicity of solutions.
- Published
- 2022
- Full Text
- View/download PDF
30. Nonlinear ghost waves accelerate the progression of high-grade brain tumors.
- Author
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Rosa Pardo, Alicia Martínez-González, and Víctor M. Pérez-García
- Published
- 2016
- Full Text
- View/download PDF
31. Neural tube defects prevalence does not increase after modification of the folic acid fortification program in Chile
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Rosa Pardo, Marcela Vilca, Luis Villarroel, Tahera Davalji, John F. Obrycki, Maitreyi Mazumdar, Claudia Avila, and Cecilia Mellado
- Subjects
Embryology ,Health, Toxicology and Mutagenesis ,Flour ,Toxicology ,Folic Acid ,Pregnancy ,Food, Fortified ,Pediatrics, Perinatology and Child Health ,Prevalence ,Humans ,Female ,Neural Tube Defects ,Chile ,Triticum ,Developmental Biology - Abstract
In 2000, Chile's Ministry of Health mandated fortification of wheat flour with folic acid at a concentration of 2.2 mg/kg to prevent neural tube defects (NTDs), resulting in a 50% reduction in NTD prevalence. Concerns about possible collateral effects of high folic acid intake led, in 2009, to decrease the folic acid fortification to 1.8 mg/kg of flour. Our study evaluated the impact of this modification on the prevalence of NTDs in Santiago.This study measured the prevalence of NTDs in live births and stillbirths born in Santiago. We calculated prevalence ratios (PR) and 95% confidence intervals (CI) between pre-folic acid fortification (1999-2000), post-folic acid fortification (2001-2009), and post-modified folic acid fortification (2010-2015) periods for all NTDs and their specific types. We used chi-square tests to analyze proportions, and a Joinpoint regression to visualize prevalence time trends.The NTD prevalence for the period 2001-2015 was 8.9 per 10,000 births, which represents a 48% reduction (PR = 0.52; 95% CI = 0.45-0.61; p .001) from the pre-folic acid fortification period. During 2010-2015, the NTD prevalence was 9.5/10,000 births, which was higher, but not statistically significantly different from 2001 to 2009 prevalence of 8.6/10,000 (PR = 1.11; 95% CI = 0.96-1.30, p = .17).Decreasing the concentration of folic acid fortification was not associated with a statistically significant change in the prevalence of NTDs. Mandatory folic acid fortification continues to be a safe and highly effective policy to prevent NTDs. Future studies should evaluate the prevalence of NTDs across Chile and adherence to folic acid fortification mandates.
- Published
- 2022
- Full Text
- View/download PDF
32. Revisiting the nontemplate approach for the synthesis of highly green emissive hybrid perovskite nanocrystals: platelets or spheres?
- Author
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Ignacio Rosa-Pardo, Rita B. Cevallos-Toledo, Lakshminarayana Polavarapu, Raul Arenal, Raquel E. Galian, Julia Pérez-Prieto, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Generalitat Valenciana, European Commission, Xunta de Galicia, Gobierno de Aragón, Ministerio de Economía y Competitividad (España), and Diputación General de Aragón
- Subjects
General Materials Science - Abstract
The long-standing debate about the morphology of colloidal methylammonium lead bromide perovskites nanocrystals, manufactured by our nontemplate synthetic strategy reported in 2014, is now resolved; specifically, the highest green emissive single nanoplatelets (of up to 93%) with long-term chemical and photochemical stability have been obtained after suitable purification steps., We thank MICINN (CTQ2017-82711-P, PID2020-115710GB-100/AEI/10.13039/501100011033), MINECO (MMU Unit of Excellence “Maria de Maeztu” CEX2019-000919-M) and Generalitat Valenciana (PROMETEO/2019/080 and IDIFEDER/2018/064), all of them partially co-financed with FEDER funds. I. R-P. acknowledges the support from Spanish Ministry of Science, Innovation and Universities (FPU17/05564). L. P. acknowledges the support from MINECO through Ramón y Cajal grant (RYC2018-026103-I) and the Spanish State Research Agency (Grant No. PID2020-117371RA-I00), from the Xunta de Galicia (ED431F2021/05). The HRSTEM measurements were performed in the Laboratorio de Microscopias Avanzadas (LMA) at the Universidad de Zaragoza (Spain). R. A. acknowledges funding from the Spanish MICINN (project grant PID2019-104739GB-100/AEI/10.13039/501100011033), the Government of Aragon (project DGA E13- 20R) and European Union H2020 program “ESTEEM3” (823717).
- Published
- 2022
- Full Text
- View/download PDF
33. $$L^\infty (\Omega )$$ a priori estimates for subcritical semilinear elliptic equations with a Carathéodory non-linearity
- Author
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Rosa Pardo
- Subjects
Applied Mathematics ,Modeling and Simulation ,Geometry and Topology - Abstract
We consider a semilinear boundary value problem $$ -\Delta u= f(x,u),$$ - Δ u = f ( x , u ) , in $$\Omega ,$$ Ω , with Dirichlet boundary conditions, where $$\Omega \subset {\mathbb {R}}^N $$ Ω ⊂ R N with $$N> 2,$$ N > 2 , is a bounded smooth domain, and f is a Carathéodory function, superlinear and subcritical at infinity. We provide $$L^\infty (\Omega )$$ L ∞ ( Ω ) a priori estimates for weak solutions in terms of their $$L^{2^*}(\Omega )$$ L 2 ∗ ( Ω ) -norm, where $$2^*=\frac{2N}{N-2}\ $$ 2 ∗ = 2 N N - 2 is the critical Sobolev exponent. In particular, our results also apply to $$f(x,s)=a(x)\,\frac{|s|^{2^*_{N/r}-2}s}{\big [\log (e+|s|)\big ]^\beta }\,$$ f ( x , s ) = a ( x ) | s | 2 N / r ∗ - 2 s [ log ( e + | s | ) ] β , where $$a\in L^r(\Omega )$$ a ∈ L r ( Ω ) with $$N/2 N / 2 < r ≤ ∞ , and $$2_{N/r}^*:=2^*\left( 1-\frac{1}{r}\right) $$ 2 N / r ∗ : = 2 ∗ 1 - 1 r . Assume $$N/2 N / 2 < r ≤ N . We show that for any $$\varepsilon >0$$ ε > 0 there exists a constant $$C_\varepsilon >0$$ C ε > 0 such that for any solution $$u\in H^1_0(\Omega )$$ u ∈ H 0 1 ( Ω ) , the following holds: $$\begin{aligned} \Big [\log \big (e+\Vert u\Vert _{\infty }\big )\Big ]^\beta \le C _\varepsilon \, \Big (1+\Vert u\Vert _{2^*}\Big )^{\, (2^*_{N/r}-2)(1+\varepsilon )}. \end{aligned}$$ [ log ( e + ‖ u ‖ ∞ ) ] β ≤ C ε ( 1 + ‖ u ‖ 2 ∗ ) ( 2 N / r ∗ - 2 ) ( 1 + ε ) . To establish our results, we do not assume any restrictions on the sign of the solutions, or on the non-linearity. Our approach is based on Gagliardo–Nirenberg and Caffarelli–Kohn–Nirenberg interpolation inequalities. Finally, we state sufficient conditions for having $$H_0^1(\Omega )$$ H 0 1 ( Ω ) uniform a priori bounds for non-negative solutions, so finally we provide suficient conditions for having $$L^\infty (\Omega )$$ L ∞ ( Ω ) uniform a priori bounds, which holds roughly speaking for superlinear and subcritical non-linearities.
- Published
- 2023
- Full Text
- View/download PDF
34. Contributors
- Author
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Yaser Abdi, Irfan Ahmed, Jamilur R. Ansari, A. Arulraj, Fatemeh Behrouznejad, Cristina Besleaga, Rachel Elizabeth Brophy, Paulina Carmona-Monroy, Amreesh Chandra, Yonghua Chen, Faisal Islam Chowdhury, Towhid H. Chowdhury, Alejandro Cortés-Villena, Marina Cuzminschi, Sarah Derbali, Nicolae Filipoiu, Mihaela Florea, Raquel E. Galian, Somayeh Gholipour, Subrata Ghosh, G. Krishnamurthy Grandhi, Meenakshi Gussain, Mahboubeh Hadadian, Waseem Haider, Mohammad Hatamvand, Wei Huang, Neha Jain, Sakshi Kansal, Movaffaq Kateb, Mohammad Khalid, Dinesh Kumar, Maning Liu, Chung-Hsin Lu, R.V. Mangalaraja, Andrei Manolescu, Pandiyarajan Mariyappan, Mohan Lal Meena, Tudor Luca Mitran, Md. Farhan Naseh, George Alexandru Nemnes, Julia Pérez-Prieto, Ioana Pintilie, Shivam Porwal, Surbhi Priya, M. Atikur Rahman, C. Rajkumar, Bart Roose, Ignacio Rosa-Pardo, Mohammad Sajedi Alvar, T.S. Shyju, Anupriya Singh, Rajan Kumar Singh, Trilok Singh, Diego Solis-Ibarra, Sudipta Som, Viorica Stancu, Choudhary Arjun Sunilbhai, Radha Tamrakar, Andrei G. Tomulescu, Brenda Vargas, P. Vengatesh, Paola Vivo, Mozhgan Yavari, and Yiqiang Zhan
- Published
- 2023
- Full Text
- View/download PDF
35. Synthesis techniques of metal halide perovskites
- Author
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Ignacio Rosa-Pardo, Alejandro Cortés-Villena, Raquel E. Galian, and Julia Pérez-Prieto
- Published
- 2023
- Full Text
- View/download PDF
36. Impact of Surface Chemistry on the Application of Colloidal Semiconductor Nanocrystals
- Author
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Raquel E. Galian, Ignacio Rosa Pardo, Alejandro Cortés Villena, Rita Toledo Cevallos, and Julia Pérez Prieto
- Published
- 2022
- Full Text
- View/download PDF
37. Chapter 4 - Synthesis techniques of metal halide perovskites
- Author
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Rosa-Pardo, Ignacio, Cortés-Villena, Alejandro, Galian, Raquel E., and Pérez-Prieto, Julia
- Published
- 2023
- Full Text
- View/download PDF
38. One-Pot Synthesis of Stable CsPbBr3@CsPb2Br5 Core–Shell Heteronanocrystals with Controlled Permeability to Halide Ions.
- Author
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Rosa-Pardo, Ignacio, Ciccone, Alessandro, Arenal, Raúl, Galian, Raquel E., and Pérez-Prieto, Julia
- Published
- 2023
- Full Text
- View/download PDF
39. Infinite Resonant Solutions and Turning Points in a Problem with Unbounded bifurcation.
- Author
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José M. Arrieta, Rosa Pardo, and Aníbal Rodríguez-Bernal
- Published
- 2010
- Full Text
- View/download PDF
40. La política exterior de los gobiernos de Felipe González: ¿un nuevo papel para España en el escenario internacional?
- Author
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Sanz, Rosa Pardo
- Published
- 2011
41. The Latin American network for congenital malformation surveillance: <scp>ReLAMC</scp>
- Author
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Lucas Gabriel Gimenez, Marta Ascurra, Paula Hurtado-Villa, Jorge S. Lopez-Camelo, Maria Aurora Canessa‐Tapia, Dania Maria Pastora, Flávia Martinez de Carvalho, Daniel Mattos Correa, Iêda M. Orioli, Adriana Benavides-Lara, Boris Groisman, Flávia Schneider Soares, Giovanny Vinícius Araújo de França, Marisol Ibarra-Ramírez, Mariana Piola, Rosa Pardo, Helen Dolk, Ignacio Zarante, and Eliana de Aquino Bonilha
- Subjects
education.field_of_study ,Pediatrics ,medicine.medical_specialty ,Down syndrome ,Latin Americans ,Spina bifida ,business.industry ,Population ,Infant, Newborn ,Prevalence ,Early detection ,Epidemiologic Surveillance ,medicine.disease ,Congenital Abnormalities ,Latin America ,Conjoined twins ,Genetics ,medicine ,Humans ,Registries ,Chile ,education ,business ,Genetics (clinical) - Abstract
The early detection of congenital anomaly epidemics occurs when comparing current with previous frequencies in the same population. The success of epidemiologic surveillance depends on numerous factors, including the accuracy of the rates available in the base period, wide population coverage, and short periodicity of analysis. This study aims to describe the Latin American network of congenital malformation surveillance: ReLAMC, created to increase epidemiologic surveillance in Latin America. We describe the main steps, tasks, strategies used, and preliminary results. From 2017 to 2019, five national registries (Argentina [RENAC], Brazil [SINASC/SIM-BRS], Chile [RENACH], Costa Rica [CREC], Paraguay [RENADECOPY-PNPDC]), six regional registries (Bogotá [PVSDC-Bogota], Cali [PVSDC-Cali], Maule [RRMC SSM], Nicaragua [SVDC], Nuevo-León [ReDeCon HU], São Paulo [SINASC/SIM-MSP]) and the ECLAMC hospital network sent data to ReLAMC on a total population of 9,152,674 births, with a total of 101,749 malformed newborns (1.1%; 95% CI 1.10-1.12). Of the 9,000,651 births in countries covering both live and stillbirths, 88,881 were stillborn (0.99%; 95% CI 0.98-0.99), and among stillborns, 6,755 were malformed (7.61%; 95% CI 7.44-7.79). The microcephaly rate was 2.45 per 10,000 births (95% CI 2.35-2.55), hydrocephaly 3.03 (2.92-3.14), spina bifida 2.89 (2.78-3.00), congenital heart defects 15.53 (15.27-15.79), cleft lip 2.02 (1.93-2.11), cleft palate and lip 2.77 (2.66-2.88), talipes 2.56 (2.46-2.67), conjoined twins 0.16 (0.14-0.19), and Down syndrome 5.33 (5.18-5.48). Each congenital anomaly showed heterogeneity in prevalence rates among registries. The harmonization of data in relation to operational differences between registries is the next step in developing the common ReLAMC database.
- Published
- 2020
- Full Text
- View/download PDF
42. Nonsyndromic orofacial clefts in Chile: LINE-1 methylation and MTHFR variants
- Author
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Noemí Leiva, Rosa Pardo, Gabriela Cáceres-Rojas, José Luis Santos, José Suazo, Roberto Pantoja, Bernardo J. Krause, Andrea S. Recabarren, Carlos Salamanca, and Pamela A. Recabarren
- Subjects
0301 basic medicine ,Cancer Research ,Adolescent ,Cleft Lip ,Polymorphism, Single Nucleotide ,03 medical and health sciences ,0302 clinical medicine ,Genetics ,Humans ,Chile ,Child ,Methylenetetrahydrofolate Reductase (NADPH2) ,biology ,Infant, Newborn ,Brain ,Infant ,DNA Methylation ,Cleft Palate ,Long Interspersed Nucleotide Elements ,030104 developmental biology ,Case-Control Studies ,Child, Preschool ,030220 oncology & carcinogenesis ,Methylenetetrahydrofolate reductase ,DNA methylation ,biology.protein ,Line 1 methylation - Abstract
Aim: To evaluate the risk of nonsyndromic orofacial clefts (NSOFCs) associated with LINE-1 methylation, as a marker of global DNA methylation, and the effect of MTHFR functional variants on this variable. Patients & methods: LINE-1 methylation was evaluated by bisulfite modification coupled to DNA pyrosequencing in 95 NSOFC cases and 95 controls. In these subjects, MTHFR genotypes for variants c.C677T (rs1801133) and c.A1298C (rs1801131) were obtained. Results: Middle levels (second tertile) of LINE-1 methylation increase the risk of NSOFCs. In addition, LINE-1 methylation depends on c.A1298C genotypes in controls but not in cases. Conclusion: A nonlinear association between global DNA methylation and NSOFCs was detected in this Chilean population, which appears to be influenced by MTHFR functional variants.
- Published
- 2020
- Full Text
- View/download PDF
43. Trisomía 9, trisomía 13 y trisomía 18: Resultados del análisis citogenético prenatal, Hospital Clínico Universidad de Chile, años 2000-2017
- Author
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Rosa Pardo, Silvia Castillo, Salazar S, Carolina Sanhueza, Lorena Tobella, Vera Daher, María Zavala, and Patricia Sanz
- Subjects
Obstetrics and Gynecology - Published
- 2020
- Full Text
- View/download PDF
44. Genetic variants in S-adenosyl-methionine synthesis pathway and nonsyndromic cleft lip with or without cleft palate in Chile
- Author
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Andrea S. Recabarren, Noemí Leiva, José Suazo, Pamela A. Recabarren, Roberto Pantoja, Patricio Gonzalez-Hormazabal, Carlos Salamanca, and Rosa Pardo
- Subjects
Male ,S-Adenosylmethionine ,Genotype ,Cleft Lip ,Population ,Genes, Recessive ,Single-nucleotide polymorphism ,Biology ,5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase ,Polymorphism, Single Nucleotide ,chemistry.chemical_compound ,Methionine ,Gene Frequency ,Odds Ratio ,Humans ,Genetic Predisposition to Disease ,S-Adenosyl methionine ,Chile ,Allele ,education ,Alleles ,Genes, Dominant ,Genetics ,education.field_of_study ,Adenosylhomocysteinase ,Haplotype ,Methionine Adenosyltransferase ,Methylation ,MTRR ,Cleft Palate ,Ferredoxin-NADP Reductase ,Haplotypes ,chemistry ,Pediatrics, Perinatology and Child Health ,DNA methylation ,Female - Abstract
Background The S-adenosyl-methionine (SAM) availability is crucial for DNA methylation, an epigenetic mechanism involved in nonsyndromic cleft lip with or without cleft palate (NSCL/P) expression. The aim of this study was to assess the association between single-nucleotide polymorphisms (SNPs) of genes involved in SAM synthesis and NSCL/P in a Chilean population. Methods In 234 cases and 309 controls, 18 SNPs in AHCY, MTR, MTRR, and MAT2A were genotyped, and the association between them and the phenotype was evaluated based on additive (allele), dominant, recessive and haplotype models, by odds ratio (OR) computing. Results Three deep intronic SNPs of MTR showed a protective effect on NSCL/P expression: rs10925239 (OR 0.68; p = 0.0032; q = 0.0192), rs10925254 (OR 0.66; p = 0.0018; q = 0.0162), and rs3768142 (OR 0.66; p = 0.0015; q = 0.0162). Annotations in expression database demonstrate that the protective allele of the three SNPs is associated with a reduction of MTR expression summed to the prediction by bioinformatic tools of its potentiality to modify splicing sites. Conclusions The protective effect against NSCL/P of these intronic MTR SNPs seems to be related to a decrease in MTR enzyme expression, modulating the SAM availability for proper substrate methylation. However, functional analyses are necessary to confirm our findings. Impact SAM synthesis pathway genetic variants are factors associated to NSCL/P. This article adds new evidence for folate related genes in NSCL/P in Chile. Its impact is to contribute with potential new markers for genetic counseling.
- Published
- 2020
- Full Text
- View/download PDF
45. Vitamin B12 Transport Genes and Nonsyndromic Cleft Lip With or Without Cleft Palate in Chile
- Author
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José Suazo, Carlos Salamanca, Gabriela Cáceres-Rojas, Patricio González-Hormazábal, Roberto Pantoja, Noemi Leiva, and Rosa Pardo
- Subjects
Cleft Palate ,Vitamin B 12 ,Genotype ,Case-Control Studies ,Cleft Lip ,Obstetrics and Gynecology ,Humans ,Genetic Predisposition to Disease ,Chile ,Polymorphism, Single Nucleotide - Abstract
The aims of this study were to assess the association between polymorphisms within genes involved in vitamin B12 transport and nonsyndromic cleft lip with or without cleft palate (NSCL/P) and global DNA methylation in Chile. From 247 cases and 453 controls, we obtained variant genotypes for CBLIF, CUBN, AMN, ABCC1, CD320, and TCN2 from a single nucleotide polymorphisms array. Global DNA methylation in 95 controls was obtained through LINE-1 methylation. After multiple comparison corrections, only rs780807 in CUBN remains associated with NSCL/P at dominant model (OR 0.564, p-value = 0.0006, q-value = 0.0450). Carriers of protective allele showed lower levels of DNA methylation than non-carriers (p = 0.0259). Further studies are necessary in order to explain relations with the phenotype and DNA methylation due to the absence of functional evidence for rs780807 in CUBN.
- Published
- 2022
46. Revisiting the nontemplate approach for the synthesis of highly green emissive hybrid perovskite nanocrystals: Platelets or spheres?
- Author
-
Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Generalitat Valenciana, European Commission, Xunta de Galicia, Gobierno de Aragón, Ministerio de Economía y Competitividad (España), Diputación General de Aragón, Rosa-Pardo, Ignacio, Cevallos-Toledo, Rita B., Polavarapu, Lakshminarayana, Arenal, Raúl, Galian, Raquel E., Pérez-Prieto, Julia, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Generalitat Valenciana, European Commission, Xunta de Galicia, Gobierno de Aragón, Ministerio de Economía y Competitividad (España), Diputación General de Aragón, Rosa-Pardo, Ignacio, Cevallos-Toledo, Rita B., Polavarapu, Lakshminarayana, Arenal, Raúl, Galian, Raquel E., and Pérez-Prieto, Julia
- Abstract
The long-standing debate about the morphology of colloidal methylammonium lead bromide perovskites nanocrystals, manufactured by our nontemplate synthetic strategy reported in 2014, is now resolved; specifically, the highest green emissive single nanoplatelets (of up to 93%) with long-term chemical and photochemical stability have been obtained after suitable purification steps.
- Published
- 2022
47. Blue-emissive ultrathin Perovskite nanosheets
- Author
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Cevallos-Toledo, Rita B., Rosa-Pardo, Ignacio, Arenal, Raúl, Oestreicher, Víctor, Fickert, Michael, Abellán, Gonzalo, Galian, Raquel E., Pérez-Prieto, Julia, Cevallos-Toledo, Rita B., Rosa-Pardo, Ignacio, Arenal, Raúl, Oestreicher, Víctor, Fickert, Michael, Abellán, Gonzalo, Galian, Raquel E., and Pérez-Prieto, Julia
- Abstract
Colloidal lead halide perovskites (LHPs) are relatively new semiconductor materials which are attracting great interest due to their outstanding optoelectronic properties. The most studied materials present the APbX3 formula, where A is a small-sized organic or metal mono-cation and X is a halide anion and present a three-dimensional (3D) inorganic framework. LHPs can also be prepared with other stoichiometries and different morphologies. Here, the preparation of highly (photo)chemical and colloidal stable hybrid LHP nanosheets (NSs) of ca. 7.4 um lateral size and 2.5 nm quantum well height (thereby presenting a deep blue emission at ca. 440 nm) is reported for the first time. The NSs are close-lying and they even interconnect when deposited on a substrate (Figure 1: Figure 1. a) TEM image of LHP@DDA/pTSEuNDs NSs; inset: size distribution and colloidal dispersion under UV light. b) Chemical stability over the course of 8 h in air; inset: normalized absorbance (t= 0 and 8 h).). Their synthesis is based on the use of the p-toluenesulfonic acid/dodecylamine (pTS/DDA) ligands pair and their (photo)chemical stability and photoluminescence is enhanced by adding EuBr2 nanodots (EuNDs). Other stabilization methods were tested to stablish which is the better way to obtain stable NSs.
- Published
- 2022
48. Chapter 8 - Preparing the workforce for genomic medicine: International challenges and strategies
- Author
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Johnson, Desalyn L., Korf, Bruce R., Ascurra, Marta, El-Kamah, Ghada, Fieggen, Karen, de la Fuente, Beatriz, Mahmood, Saqib, Rojas-Martinez, Augusto, Montenegro-Garreaud, Ximena, Moresco, Angelica, Mountain, Helen, Pachter, Nicholas, Puri, Ratna Dua, Raggio, Victor, Thakur, Nilam, and Vargas, Rosa Pardo
- Published
- 2022
- Full Text
- View/download PDF
49. Low-dimensional halide perovskites as deep blue-emissive colloidal materials
- Author
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Raquel E. Galian, Ignacio Rosa-Pardo, Rita Rita Cevallos-Toledo, and Julia Pérez-Prieto
- Published
- 2022
- Full Text
- View/download PDF
50. Contributors
- Author
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Michelle E. Abadingo, Marta Ascurra, Michelle Bishop, Kathleen Calzone, Eva Maria C. Cutiongco-de la Paz, Vajira H.W. Dissanayake, Ghada El-Kamah, Karen Fieggen, Clara L. Gaff, Desalyn L. Johnson, Bruce R. Korf, Dhavendra Kumar, Beatriz de la Fuente, Elly Lynch, Ebner Bon G. Maceda, Saqib Mahmood, Melissa Martyn, A. Middleton, Ximena Montenegro-Garreaud, Angelica Moresco, Helen Mountain, Amy Nisselle, Nicholas Pachter, Carmencita D. Padilla, Ratna Dua Puri, Victor Raggio, Simon Ramsden, J. Roberts, Augusto Rojas-Martinez, Anneke Seller, Alison Taylor-Beadling, Nilam Thakur, Emma Tonkin, and Rosa Pardo Vargas
- Published
- 2022
- Full Text
- View/download PDF
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